BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0029.p (189 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGpA293 [IQR] COG1028 Dehydrogenases with different specificitie... 259 3e-69 SMa1629 [IQR] COG1028 Dehydrogenases with different specificitie... 242 4e-64 mlr2535 [IQR] COG1028 Dehydrogenases with different specificitie... 212 5e-55 SMa2019 [IQR] COG1028 Dehydrogenases with different specificitie... 190 2e-48 VC2021 [IQR] COG1028 Dehydrogenases with different specificities... 107 1e-23 BS_yvrD [IQR] COG1028 Dehydrogenases with different specificitie... 105 7e-23 PM1916 [IQR] COG1028 Dehydrogenases with different specificities... 101 1e-21 PA5524 [IQR] COG1028 Dehydrogenases with different specificities... 100 2e-21 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 99 4e-21 CT237 [IQR] COG1028 Dehydrogenases with different specificities ... 99 5e-21 >AGpA293 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 259 Score = 259 bits (661), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 123/187 (65%), Positives = 150/187 (80%) Query: 2 KDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSGV 61 ++ GG+DIL+N LGGS P GGFAA++DE W EFNLN PAVR+DRAL+P M+AQGSGV Sbjct: 72 RELGGLDILVNVLGGSSAPSGGFAALTDEEWEKEFNLNFFPAVRLDRALVPGMIAQGSGV 131 Query: 62 IIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASVA 121 +IHV+SIQR LPLPE+TT YA+AK AL TYSKS+++EV+ KGVRV+ V+PGWI + Sbjct: 132 VIHVTSIQRNLPLPEATTGYASAKGALNTYSKSVSKEVSPKGVRVVRVSPGWIADPGANG 191 Query: 122 FTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYRI 181 R A AG DY ++IM+ LGGIP+GRPAKP+EVADLIAFLAS R+ASITGTE+ I Sbjct: 192 LALRIAEEAGIDYAAAVQVIMNSLGGIPLGRPAKPEEVADLIAFLASDRAASITGTEHVI 251 Query: 182 DGGTVPT 188 DGGTVPT Sbjct: 252 DGGTVPT 258 >SMa1629 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 259 Score = 242 bits (617), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 131/187 (70%), Positives = 162/187 (86%) Query: 2 KDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSGV 61 + GGVD++++ LGGS GGGF+A+SD+ W+ E +LNL AVR+DR L+P+M+A+GSGV Sbjct: 72 QRLGGVDVIVHMLGGSSAAGGGFSALSDDDWYNELSLNLFAAVRLDRQLVPDMVARGSGV 131 Query: 62 IIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASVA 121 ++HV+SIQRVLPLPESTTAYAAAKAAL+TYSK++++EV+ KGVRV+ V+PGWIETEASV Sbjct: 132 VVHVTSIQRVLPLPESTTAYAAAKAALSTYSKAMSKEVSPKGVRVVRVSPGWIETEASVR 191 Query: 122 FTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYRI 181 +R A AGTD EGGKKIIMD LGGIP+GRPAKP+EVA+LIAFLAS R+ASITG EY I Sbjct: 192 LAERLAKQAGTDLEGGKKIIMDGLGGIPLGRPAKPEEVANLIAFLASDRAASITGAEYTI 251 Query: 182 DGGTVPT 188 DGGTVPT Sbjct: 252 DGGTVPT 258 >mlr2535 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 262 Score = 212 bits (539), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 111/189 (58%), Positives = 147/189 (77%) Query: 1 LKDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSG 60 L GGVDIL + LGGS TPGGGF A++D++W +E NLNL+ VR+DR L+P M+A+G+G Sbjct: 74 LDRLGGVDILAHVLGGSTTPGGGFVALTDDYWLSELNLNLLATVRLDRLLIPQMIARGAG 133 Query: 61 VIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASV 120 ++HV+SIQ VLPLPE+TTAYAAAKAAL TYSKS+++E+ KGVRV +V+PGWI TE + Sbjct: 134 AVVHVTSIQSVLPLPEATTAYAAAKAALRTYSKSISKELGPKGVRVNAVSPGWIMTEGTE 193 Query: 121 AFTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYR 180 F +R A G E +++++D LGGI +GR A+P EVA+ IAFLAS R++SI G+E Sbjct: 194 VFLERIQAANGGTLEDARQLVLDGLGGIAIGRGAEPFEVAEAIAFLASDRASSIHGSELV 253 Query: 181 IDGGTVPTV 189 +DGGTVPTV Sbjct: 254 VDGGTVPTV 262 >SMa2019 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 136 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 99/135 (73%), Positives = 118/135 (87%) Query: 54 MLAQGSGVIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGW 113 M+A+G GV++HV+SIQ V+PLPESTTAYAAAKAAL+TY KS+A+E++SKG+RV+ V+PGW Sbjct: 1 MVARGCGVVVHVTSIQGVMPLPESTTAYAAAKAALSTYGKSIAKEISSKGIRVVRVSPGW 60 Query: 114 IETEASVAFTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSAS 173 I TEASV +R A AGTD EGGKKIIMD LGGIP+GRPA P+EVADLIAFLA R++S Sbjct: 61 IATEASVRLAERLAKQAGTDLEGGKKIIMDALGGIPLGRPANPEEVADLIAFLAPDRASS 120 Query: 174 ITGTEYRIDGGTVPT 188 ITGTEY IDGGTVPT Sbjct: 121 ITGTEYTIDGGTVPT 135 >VC2021 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Vch Vibrio cholerae Length = 248 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 69/184 (37%), Positives = 98/184 (53%), Gaps = 21/184 (11%) Query: 3 DWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSGVI 62 ++GGVDIL+N G T + +E W NL R+ +A+L M+ + G I Sbjct: 80 EFGGVDILVNNAG--ITRDNLLMRMKEEEWSDIMETNLTSIFRLSKAVLRGMMKKRQGRI 137 Query: 63 IHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASVAF 122 I+V S+ + YAAAKA + ++KS+AREV S+GV V +VAPG+IET+ + A Sbjct: 138 INVGSVVGTMG-NAGQANYAAAKAGVIGFTKSMAREVASRGVTVNTVAPGFIETDMTKAL 196 Query: 123 T--QRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYR 180 QRTA L +P GR P+E+A +AFLASP +A ITG Sbjct: 197 NDEQRTAT----------------LAQVPAGRLGDPREIASAVAFLASPEAAYITGETLH 240 Query: 181 IDGG 184 ++GG Sbjct: 241 VNGG 244 >BS_yvrD [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 263 Score = 105 bits (261), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 69/193 (35%), Positives = 104/193 (53%), Gaps = 10/193 (5%) Query: 1 LKDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSG 60 + + G +DIL+N LG + FA ++DE W F +N+M AVR R LP MLA+ SG Sbjct: 77 VNEIGDIDILVNNLGFFEVKD--FADVTDEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSG 134 Query: 61 VIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASV 120 I++++S V PLP + Y+ K AL + S+ +A V V SV PG TE Sbjct: 135 RILNIASEAGVKPLP-TMIPYSMTKTALISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVA 193 Query: 121 AFTQRTAAHAGTDYEGGKKIIMDWLG-GIP---VGRPAKPQEVADLIAFLASPRSASITG 176 ++ + A AG D + I D+ P + R A +EVA+ I FLAS +++I G Sbjct: 194 SYMEGAAQAAGQDTD---TFIKDYFKVNEPTSLIQRYATAEEVANTIVFLASDAASAING 250 Query: 177 TEYRIDGGTVPTV 189 T R++GG + ++ Sbjct: 251 TAQRVEGGIIRSL 263 >PM1916 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pmu Pasteurella multocida Length = 242 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 63/182 (34%), Positives = 93/182 (51%), Gaps = 17/182 (9%) Query: 3 DWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSGVI 62 D+G +DIL+N G T + DE WF NL + +A+L +M+ + G I Sbjct: 74 DFGEIDILVNNAG--ITRDNLLMRMKDEEWFDIMQTNLTSVYHLSKAMLRSMMKKRFGRI 131 Query: 63 IHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASVAF 122 I + S+ + P T Y AAKA L +SK+LA+EV S+G+ V VAPG+I T+ + Sbjct: 132 ITIGSVVGSMGNPGQTN-YCAAKAGLIGFSKALAKEVASRGITVNVVAPGFIATDMTDVL 190 Query: 123 TQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYRID 182 T+ A L +P GR P+++A +AFLAS + ITGT ++ Sbjct: 191 TEEQKAG--------------ILSQVPAGRLGDPKDIAKAVAFLASDDAGYITGTTLHVN 236 Query: 183 GG 184 GG Sbjct: 237 GG 238 >PA5524 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 260 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/188 (37%), Positives = 90/188 (47%), Gaps = 22/188 (11%) Query: 3 DWGGVDILINALG----GSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQG 58 WG VDIL+N G S P A S W + NL A + R LLP M +G Sbjct: 84 QWGRVDILVNNAGMAQLDSAEPFSAVEATSLRDWQLSLSRNLTSAFLLTRGLLPGMRERG 143 Query: 59 SGVIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEA 118 G I++V+S AY+AAKA L +S LA EV G+ V SVAPGWI T + Sbjct: 144 YGRIVNVASTTGTRGSNPGEAAYSAAKAGLVGWSMGLALEVAKSGITVNSVAPGWIATAS 203 Query: 119 SVAFTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTE 178 S A +R AA A P GR +P+EVA +AFLASP ++ + G Sbjct: 204 STA-EERQAALAS-----------------PSGRAGRPEEVAAAVAFLASPEASFVNGEL 245 Query: 179 YRIDGGTV 186 +DGG Sbjct: 246 LVVDGGNC 253 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 62/186 (33%), Positives = 101/186 (54%), Gaps = 17/186 (9%) Query: 1 LKDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSG 60 ++ +G +D+L+N G ++ + +E W A N+NL + + ++P M+ Q +G Sbjct: 77 VQKYGRIDVLVNNAGITRD--ALLVRMKEEDWDAVINVNLKGVFNVTQMVVPYMIKQRNG 134 Query: 61 VIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASV 120 I++VSS+ + P T YAA+KA + +K+ A+E+ + +RV +VAPG+IET + Sbjct: 135 SIVNVSSVVGIYGNPGQTN-YAASKAGVIGMTKTWAKELAGRNIRVNAVAPGFIETPMTE 193 Query: 121 AFTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYR 180 ++ A L IP+GR KP+EVA +I FLAS S+ +TG Sbjct: 194 KLPEKARETA--------------LSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIG 239 Query: 181 IDGGTV 186 IDGG V Sbjct: 240 IDGGLV 245 >CT237 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ctr Chlamydia trachomatis Length = 248 Score = 99.0 bits (245), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 62/184 (33%), Positives = 98/184 (53%), Gaps = 17/184 (9%) Query: 1 LKDWGGVDILINALGGSKTPGGGFAAISDEHWFAEFNLNLMPAVRMDRALLPNMLAQGSG 60 L ++ +D+++N G T +S+E W + N NL + A++ M+ SG Sbjct: 80 LAEYNTIDVIVNNAG--ITRDALLMRMSEEEWSSVINTNLGSIYNVCSAVIRPMIKARSG 137 Query: 61 VIIHVSSIQRVLPLPESTTAYAAAKAALTTYSKSLAREVTSKGVRVLSVAPGWIETEASV 120 II++SSI + P T YAAAKA + +SK+L++EV SK +RV +APG+I+T+ + Sbjct: 138 AIINISSIVGLRGSPGQTN-YAAAKAGIIGFSKALSKEVGSKNIRVNCIAPGFIDTDMTK 196 Query: 121 AFTQRTAAHAGTDYEGGKKIIMDWLGGIPVGRPAKPQEVADLIAFLASPRSASITGTEYR 180 + + +WL G+P+GR P+E+A FLAS S+ ITG Sbjct: 197 SLND--------------NLKNEWLKGVPLGRVGMPEEIAKAALFLASDGSSYITGQVLS 242 Query: 181 IDGG 184 +DGG Sbjct: 243 VDGG 246