BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0027.p (359 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll1685 [GEPR] COG0477 Permeases of the major facilitator superf... 315 7e-86 mlr2429 [GEPR] COG0477 Permeases of the major facilitator superf... 105 2e-22 SMb20272 [GEPR] COG0477 Permeases of the major facilitator super... 97 4e-20 BH2694 [GEPR] COG0477 Permeases of the major facilitator superfa... 82 2e-15 BS_ycxA [GEPR] COG0477 Permeases of the major facilitator superf... 81 5e-15 AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 75 2e-13 VCA0554 [GEPR] COG0477 Permeases of the major facilitator superf... 66 2e-10 YOL119c [GEPR] COG0477 Permeases of the major facilitator superf... 65 3e-10 BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superf... 63 1e-09 >mll1685 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 469 Score = 315 bits (808), Expect = 7e-86, Method: Compositional matrix adjust. Identities = 188/380 (49%), Positives = 241/380 (63%), Gaps = 34/380 (8%) Query: 1 MRLCITMVLMVVGASGMYVIAVVLPYVQAHYYVDRGLASMPYTLTMLGVGVGGLLMGRMA 60 MRL I+MVL +GA GM+ + VVLP VQ + VDR ASMPYT TM+G G +L+GR Sbjct: 80 MRLAISMVLATIGAVGMWAVVVVLPAVQGEFGVDRAAASMPYTATMVGFAAGNVLVGRAI 139 Query: 61 DRAGITRPLFLGGLCLGGGFIAASYAPDIWTFMAVHCLFIGLLGTSATFSPLVADTSLWF 120 DR G P + + L G + A+ + I F + IG+ GTS F PL+AD S WF Sbjct: 140 DRMGYWIPALISSVALSAGLLLAALSTSILQFTLAQGVLIGV-GTSVIFGPLIADISHWF 198 Query: 121 RKRRGIAVAVCASGNYLGGAIWPPIVQYFVDNYGWQETYRGLGLICILVMCPLALLMRTR 180 +RRG+AV A+GNYL GA+WP I+ + GW+ TY +G+ C++ M PL L++R Sbjct: 199 NRRRGVAVTAAAAGNYLAGALWPTIMPTLIKAEGWRFTYAAIGIFCLVTMVPLVLMLRRG 258 Query: 181 PPAQDSSAA----SARPXPAR--------------------RPRTA--------GAPAAR 208 P + + S +P P P+ G A Sbjct: 259 APEATADGSPGSRSVQPIPMSPAAMQGLLVVAGLGCCVAMSMPQVHIVAYCMDLGYGMAH 318 Query: 209 GAQMLSLMLACGVVSRLVSGAICDRIGGLRTLLLGSMLQGLSLLLFIPFDSLASLYLISA 268 GA MLS+M+A GVVSRL SG + DRIGG++TLL+GS+LQ LSLL +IPFD LASLY++S Sbjct: 319 GADMLSIMMAAGVVSRLASGFVADRIGGVKTLLIGSVLQCLSLLFYIPFDGLASLYVVSL 378 Query: 269 LFGLFQGGIVPSYAIIVREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSYHA 328 +FGL QGGIVP YAIIVREY PA EAGQR+G V+MAT+FGMA+GGW+SG I+D+TGSY Sbjct: 379 VFGLSQGGIVPCYAIIVREYLPAKEAGQRIGIVMMATIFGMAIGGWMSGWIYDLTGSYAV 438 Query: 329 AFANGIAWNLLNL-AIALFL 347 AF NGIAWNLLN+ AI LF+ Sbjct: 439 AFLNGIAWNLLNIGAIGLFM 458 >mlr2429 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 400 Score = 105 bits (262), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 97/352 (27%), Positives = 161/352 (45%), Gaps = 41/352 (11%) Query: 17 MYVIAVVLPYVQAHYYVDRGLASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCL 76 M+ +A+ L + R S TL L +G+GG G ++DR G + +G + L Sbjct: 24 MFSLAIFLEPMALDTQWSRAGISSAMTLNFLVMGLGGFAWGALSDRFGARIVVAIGAVLL 83 Query: 77 GGGFIAASYAPDIWTFMAVHCLFIGLLGTSATFSPLVADTSLWFRKRRGIAVAVCASGNY 136 G + AS A + TF + + +GL SA F+P++A T+ WF R +AV++ ++G Sbjct: 84 GLALVVASRAGSLLTFQISYGVLVGL-AASAFFAPMIALTTAWFDTNRSLAVSLVSAGMG 142 Query: 137 LGGAIWPPIVQYFVDNYGWQETYRGLGLICILVMCPLALLMRTRPPAQDSSAASARPXPA 196 + P ++ + Y W+ +G++ +++ P LL+R +PP +A ++ P A Sbjct: 143 VAPMTISPFARWLISAYEWRTAMFDIGIMAWVLLLPAVLLVR-QPPKPAVAAGASAPV-A 200 Query: 197 RRPRTAGAPAARGAQ---------------------MLSLMLACGVV------------- 222 + A A R Q M+S + CGV Sbjct: 201 EGAGMSVAQALRSPQFIVLGLTFFTCCAAHSGPIFHMVSYAMLCGVAPMAAVTIYSVEGL 260 Query: 223 ----SRLVSGAICDRIGGLRTLLLGSMLQGLSLLLFIPFDSLASLYLISALFGLFQGGIV 278 RL+ G + DR+G L+ G ++Q + + ++ L Y+++ +FG GG++ Sbjct: 261 AGLGGRLLYGVLADRLGVKPVLITGLVIQAVVIAAYLSVSQLDQFYVLAVIFGATYGGVM 320 Query: 279 PSYAIIVREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSYHAAF 330 P YA++ REYF G GA M + GMALG G +FD SYH F Sbjct: 321 PLYAVLAREYFGQRILGTVFGAATMLSSLGMALGPLAGGMVFDAYASYHWLF 372 >SMb20272 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 402 Score = 97.4 bits (241), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 113/256 (44%), Gaps = 35/256 (13%) Query: 106 SATFSPLVADTSLWFRKRRGIAVAVCASGNYLGGAIWPPIVQYFVDNYGWQETYRGLGLI 165 +A F+P++A + WF R +AV++ ++G + P+ + V Y W+ + + + + Sbjct: 113 AAIFAPMMACVTGWFDTHRSLAVSLVSAGMGMAPMTMSPLAGWLVTIYDWRTSLQIIAAL 172 Query: 166 CILVMCPLALLMRTRPPAQDSSAASARPXPA--------RRPR----------------- 200 + M P ALL+R P +D++A SA R P+ Sbjct: 173 AAVTMIPAALLLRRPPVLEDTNAVSASEGQPDMSLGQALRSPQFVILLLTNFFCCATHSG 232 Query: 201 ----------TAGAPAARGAQMLSLMLACGVVSRLVSGAICDRIGGLRTLLLGSMLQGLS 250 + G P + SL G+ R+ G + DR G R L+ G +LQ Sbjct: 233 PIFHTVSYAVSCGIPMMAAVSIYSLEGLAGMGGRVAFGVLGDRYGAKRILVSGLLLQAFG 292 Query: 251 LLLFIPFDSLASLYLISALFGLFQGGIVPSYAIIVREYFPAAEAGQRVGAVIMATMFGMA 310 L + L + Y ++A+FG G++P YA+I RE FP G +G MA GMA Sbjct: 293 ALAYFFVRDLGAFYAVAAVFGFIYAGVMPLYAVIARENFPLRMMGTVIGGTAMAGSLGMA 352 Query: 311 LGGWVSGKIFDMTGSY 326 +G G I+D+ SY Sbjct: 353 IGPVAGGLIYDVFASY 368 >BH2694 [GEPR] COG0477 Permeases of the major facilitator superfamily Bha Bacillus halodurans Length = 418 Score = 81.6 bits (200), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/352 (22%), Positives = 139/352 (39%), Gaps = 47/352 (13%) Query: 21 AVVLPYVQAHYYVDRGLASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCLGGGF 80 A V P+ + + +DRG S+ TL+ + G+ L+G++ DR G L L +G F Sbjct: 31 AFVQPW-ETEFSMDRGSISLISTLSFIVYGISQPLIGKLVDRLGARFILSCSTLLVGVSF 89 Query: 81 IAASYAPDIWTFMAVHCLFIGLLGTSATFSPLVADTSLWFRKRRGIAVAVCASGNYLGGA 140 + + A W ++ + + + A+ + WF K+RG+A + +G G Sbjct: 90 VLTTMATQPWHLFILYGVVVSIGVGGASNVAATVVITNWFNKKRGLAFGIIEAGFGAGQM 149 Query: 141 IWPPIVQYFVDNYGWQETYRGLGLICILVMCPLALLMRTRPPAQ----------DSSAAS 190 I P + W+ T LG +++ P+ LL+ P++ + + Sbjct: 150 ILVPGSLMLIQWLDWKATVVILGFFLAVIVFPIVLLLLRNHPSEKQVEPIGGVREEEETN 209 Query: 191 ARPXPAR---------RP---------------------------RTAGAPAARGAQMLS 214 P A RP G + + +S Sbjct: 210 TSPNSATFSNWSVFRMRPFWFLVLPFAICGFTTTGLMDTHLIPLSHDHGFSTSVTSAAVS 269 Query: 215 LMLACGVVSRLVSGAICDRIGGLRTLLLGSMLQGLSLLLFIPFDSLASLYLISALFGLFQ 274 L+ +V L+SG I DR + L L + + LSL++ + L + LFGL Sbjct: 270 LLAGFNIVGILLSGVIADRWSSRKFLFLLYVARALSLVILVHSHDPLLLLGFAILFGLVD 329 Query: 275 GGIVPSYAIIVREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSY 326 V ++ +YF G +G + ++ G ALG +V G +++ TGSY Sbjct: 330 FATVAPTQLLATQYFKRYSIGLMIGWLFLSHQVGSALGAYVPGLLYEQTGSY 381 >BS_ycxA [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 409 Score = 80.9 bits (198), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 84/345 (24%), Positives = 137/345 (39%), Gaps = 44/345 (12%) Query: 23 VLPYVQAHYYVDRGLASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCLGGGFIA 82 +LP A ++ DR L S+ ++ M+ G+ +G DR + + + LG +C+ F+ Sbjct: 33 MLPMADA-FHADRSLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLV 91 Query: 83 ASYAPDIWTFMAVHCLFIGLLGTSATFSPLVADTSLWFRKRRGIAVAVCASGNYLGGAIW 142 Y+P++ F A++ + G+ + A S WF +G+A+A+ + N G + Sbjct: 92 LPYSPNVHVFSAIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLVVS 151 Query: 143 PPIVQYFVDNY-GWQETYRGLGLICILVMCPLALLMRTRPPAQDSSAASARPXPARRPRT 201 PP + + GWQ TY LG++ V+ PL + PP + A + + R Sbjct: 152 PPPIWAAAPYHAGWQSTYTILGIVMAAVLVPLLVFGMKHPP--HAQAETVKKSYDWRGFW 209 Query: 202 AGAPAARGAQMLSL-MLACGVVSRLVSGAICD---------------------RIGGL-- 237 +R +L + CG ++ + IGGL Sbjct: 210 NVMKQSRLIHILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLA 269 Query: 238 --RTLLLGSMLQGLSLLLFIPFDSLASLYL--------------ISALFGLFQGGIVPSY 281 + LLGS LS+L FI SL L + LFGL G++P Sbjct: 270 GWLSDLLGSRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLT 329 Query: 282 AIIVREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSY 326 A + E + G +G AL + G FDMT Y Sbjct: 330 AASISESYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGY 374 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 75.5 bits (184), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 81/346 (23%), Positives = 143/346 (41%), Gaps = 55/346 (15%) Query: 34 DRGLASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCLGGGFIAASYAPDI---- 89 + +AS+P+++ +L + + GR DR G + LGG+ LG GF+ + I Sbjct: 38 SKTIASLPFSIFLLIFALMMVPAGRTQDRIGPRKVAMLGGVLLGVGFLLSGLIESIQSPY 97 Query: 90 WTFMAVHCLFIGLLGTSATFSPLVADTSLWFRKRRGIAVAVCASGNYLGGAIWPPIVQYF 149 W + I G ++ + WF +R G+A + G + I+ P+ + Sbjct: 98 WLIFSYGV--IAGAGCGLGYACPIPVARKWFPERVGLATGLVVMGFGMSALIFAPLERIL 155 Query: 150 VDNYGWQETYRGLGLICILVMCPLALLMRTRPPAQDSSAASARPXPARRPRTAGAPAARG 209 +D YG T+ LG+I ++V A L+ + PP + AS PA+ G P Sbjct: 156 IDTYGISTTFYILGVILLIVAVFAASLL-SNPPELPAVQAS---NPAKVEVVTGKPELGP 211 Query: 210 AQML--------------------------------------------SLMLACGVVSRL 225 ++ML S++ V R Sbjct: 212 SEMLRDYRFYVLWLSFFFMALAGLMVIGHIAPYAQERGLEPLAAAFAVSILSVANAVGRP 271 Query: 226 VSGAICDRIGGLRTLLLGSMLQGLSLLLFIPFD-SLASLYLISALFGLFQGGIVPSYAII 284 +GA+ D+IG T+ + ++QG++L+ F +L ++Y+ +A+ G G + Sbjct: 272 GAGALSDKIGRAMTMFVLFLIQGITLIAFPHVALTLITIYICAAIIGFNYGANFSLFPSA 331 Query: 285 VREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSYHAAF 330 ++F G G V + G +G ++G +FD+TGSY AF Sbjct: 332 TGDFFGTKNLGVNYGLVFTSYGVGGLVGPIMAGYVFDVTGSYEIAF 377 >VCA0554 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 410 Score = 65.9 bits (159), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 82/356 (23%), Positives = 142/356 (39%), Gaps = 46/356 (12%) Query: 38 ASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCLGGGFIAASYAPDIWTFMAVHC 97 AS PY + + V L+ G + DR G L LG G G IA+ +A + Sbjct: 45 ASSPYAIATIAFSVCLLVAGILQDRMGPRNILILGTTLTGLGMIASGFASSVLMLNLTFG 104 Query: 98 LFIGLLGTSATFSPLVADTSLWFR-KRRGIAVAVCASGNYLGGAIWPPIVQYFVDNYGWQ 156 + G G ++ L WF ++G+ + A+G L P+ + + G Q Sbjct: 105 VMTGA-GIGFGYACLSPSAMKWFHPSKKGMVNGLIAAGFGLAAIYLAPLTSALITHLGIQ 163 Query: 157 ETYRGLGLICILVMCPLALLMRTRP----PAQDS-SAASARPXPARRPRTAGAPAARGAQ 211 ++ LG + + PLA + P PA+ A A+ + + Q Sbjct: 164 TSFMILGAGVLAIAVPLACTINNPPAGYVPAEPKLKAGQEAKVVAKVANLSWKAMLKTPQ 223 Query: 212 MLSLMLACGVVS-------------------------------------RLVSGAICDRI 234 +L L + + R+ +G + D+I Sbjct: 224 FYALWLMYALAASVGLMIIGNITNIASVQANLPNAVYLASILAIFNSGGRVAAGILSDKI 283 Query: 235 GGLRTLLLGSMLQGLSLLLFIPFDSLASLYLISALFGLFQGGIVPSYAIIVREYFPAAEA 294 GG+RTLLL +LQG +++LF FDS +L + +A+ + G ++ + I E++ Sbjct: 284 GGVRTLLLAFLLQGGNMVLFATFDSEFTLIIGTAIAAVGYGTLLAVFPSITAEFYGLKNY 343 Query: 295 GQRVGAVIMATMFGMALGGWVSGKIFDMTGSYHAAFANGIAWNLLNLAIALFLLTR 350 G G + + G A+G V G G Y+ A+ I+ ++ + I L L+T+ Sbjct: 344 GTNYGVLYTSWGIGGAIGAAVVGYSMTHGGGYNLAYT--ISAAMMAVCILLALITK 397 >YOL119c [GEPR] COG0477 Permeases of the major facilitator superfamily Sce Saccharomyces cerevisiae Length = 501 Score = 64.7 bits (156), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 71/311 (22%), Positives = 123/311 (39%), Gaps = 47/311 (15%) Query: 54 LLMGRMADRAGITRPLFLGGLCLGGGFIAASYAPDIWTFMAVHCLFIGLLGTSATFSPLV 113 +L G DR G + G + GG A + +W F+ + GL GT +PL+ Sbjct: 153 ILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGL-GTGILMTPLI 211 Query: 114 ADTSLWFRKRRGIAVAVCASGNYLGGAIWPPIVQYFVDNYGWQETYRGLGLICILVMCPL 173 + WF KRRGIA ++ G +GG ++P +++ G+Q R L IC+ + Sbjct: 212 GTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICA 271 Query: 174 ALL--MRTRPPAQ-------------------------------------DSSAASARPX 194 ++L RT+P Q +SS S Sbjct: 272 SVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATY 331 Query: 195 PARRPRTAGAPAARGAQMLSLMLACGVVSRLVSGAICDR-IGGLRTLLLG-SMLQGLSLL 252 A T G M++ A G++ R + G D+ IG ++ SM + + Sbjct: 332 LASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFV 391 Query: 253 LFIPF-DSLASLYLISALFGLFQGGIVPSYAIIVREYFPAAEAGQRVGAVI----MATMF 307 +++PF + L+ L+G G I+ + + + + G+R V + T+ Sbjct: 392 MWLPFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIP 451 Query: 308 GMALGGWVSGK 318 + +GG + GK Sbjct: 452 VLPIGGTLIGK 462 >BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 416 Score = 62.8 bits (151), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 91/385 (23%), Positives = 154/385 (40%), Gaps = 61/385 (15%) Query: 21 AVVLPYVQAHYYVDRGLASMPYTLTMLGVGVGGLLMGRMADRAGITRPLFLGGLCLGGGF 80 A V P+ + + +DR S+ T++ + G+ ++GR+ D+ G L L G Sbjct: 30 AFVEPW-ERQFSIDRSTISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSI 88 Query: 81 IAASYAPDIWTFMAVHCLFIGLLGTSATF---SPLVADTSLWFRKRRGIAVAVCASGNYL 137 W ++ L + L A+ S LV + WF K+RG+A + +G Sbjct: 89 FLTYLVTSPWQLFLLYGLGVSLGVGGASNVAASVLVVN---WFSKKRGLAFGIMEAGFGA 145 Query: 138 GGAIWPPIVQYFVDNYGWQETYRGLGLICILVMCPLALLMRTRPPAQDSS------AASA 191 G + P + + W+ T LGL+ I+++ P ALLM P++ ++ AAS Sbjct: 146 GQMLLVPGSLMLIHWFSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASE 205 Query: 192 RPXPARRPRTAGAPAARGAQMLSLM---LACGVVSR------------------------ 224 + + + A R Q L+ L CG + Sbjct: 206 KETAPKTTALSVAGMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAA 265 Query: 225 ------------LVSGAICDRIGGLRTLLLGSMLQGLSLLLFIPFDSLASLYLISALFGL 272 L+SG + DR + L + ++ LS+++ I L + LFGL Sbjct: 266 VSLLAGFNIAGILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGL 325 Query: 273 FQGGIVPSYAIIVREYFPAAEAGQRVGAVIMATMFGMALGGWVSGKIFDMTGSYHAAFAN 332 V ++ +YF G +G + +A G ALG +V G I+ +TG Y AF Sbjct: 326 VDFATVAPTQMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAF-- 383 Query: 333 GIAWNLLNLAIALFLLTRVRSLHLR 357 L+I + +L V ++ LR Sbjct: 384 -------YLSIGMLVLASVMNVMLR 401