BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0021.0078.p (300 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2510 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 325 9e-89 BS_alsR [K] COG0583 Transcriptional regulator Bsu Bacillus subtilis 188 1e-47 ZhcaR [K] COG0583 Transcriptional regulator EcZ Escherichia coli... 181 2e-45 ECs3403 [K] COG0583 Transcriptional regulator Ecs Escherichia co... 181 2e-45 hcaR [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 180 3e-45 PA3594 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 166 5e-41 PA5029 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 161 1e-39 PA5218 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 161 2e-39 DR0615 [K] COG0583 Transcriptional regulator Dra Deinococcus rad... 160 5e-39 AGl1663 [K] COG0583 Transcriptional regulator Atu Agrobacterium ... 156 5e-38 >PA2510 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 290 Score = 325 bits (833), Expect = 9e-89, Method: Compositional matrix adjust. Identities = 165/286 (57%), Positives = 214/286 (74%), Gaps = 3/286 (1%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF A+A TL+F+RAAE LHIAQPPLSRQI+QLEEMLGV L++R RP+ LT A Sbjct: 1 MELRHLRYFQALARTLNFTRAAEQLHIAQPPLSRQIQQLEEMLGVALLERG-RPLRLTEA 59 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+FF+EQ+ +L +LE I + TR I +GQ+ WF IGFVPSALYG+LPE+I+ R + PE+ Sbjct: 60 GRFFHEQSATLLDQLESICDSTRRIGQGQRQWFGIGFVPSALYGVLPELIRHLRGD-PEL 118 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 E+G E+ T++QVEALKSGRID+GFGR+ I DP I + EEPLVA P GHPLL Sbjct: 119 ELGLLEMTTLQQVEALKSGRIDIGFGRIRIDDPAIRQSVLSEEPLVAALPAGHPLLG-QP 177 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 ++L +L+ + F+LYP +PRPSYAD VL +F++ L + + ANEMQTAIGLVAAG+G T Sbjct: 178 LSLERLSREPFVLYPGQPRPSYADHVLALFATHGLSLRVTQWANEMQTAIGLVAAGLGAT 237 Query: 241 LVPRSVQGLHRSDVVYRPLSNKGVHSPVIMNFRANDRSVLLERLRA 286 LVP SVQ HR DV Y+ L++ + SP+I++ R D S L R A Sbjct: 238 LVPASVQLQHRDDVAYQALADASLTSPIIVSRRQGDGSPHLRRCLA 283 >BS_alsR [K] COG0583 Transcriptional regulator Bsu Bacillus subtilis Length = 302 Score = 188 bits (478), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 103/284 (36%), Positives = 155/284 (54%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF AVA L F +AA L++ QPPLS+QI+QLEE +GV L+ R R + LT A Sbjct: 1 MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVGVTLLKRTKRFVELTAA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ F L ++ Q E + ARG+Q IGFV SA Y LP +++ +R + P + Sbjct: 61 GEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSATYEFLPPIVREYRKKFPSV 120 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 +I EI + Q E L G ID+G P+ + ET + P V P HPL ++ Sbjct: 121 KIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETAQSSPCVLALPKQHPLTSKES 180 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 +T+ L + I P+ + RP+IV+EA E Q IGLV+AG+G+T Sbjct: 181 ITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPNIVQEATEYQMVIGLVSAGIGMT 240 Query: 241 LVPRSVQGLHRSDVVYRPLSNKGVHSPVIMNFRANDRSVLLERL 284 VP S + L DV YR + +++ ++ +R ++ + L++ Sbjct: 241 FVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDNHNPLIKHF 284 >ZhcaR [K] COG0583 Transcriptional regulator EcZ Escherichia coli O157:H7 EDL933 Length = 296 Score = 181 bits (458), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 162/301 (53%), Gaps = 17/301 (5%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF AVA L+F+RAAE LH +QP LS QIR LE +GV L+ R R +ALT A Sbjct: 1 MELRHLRYFVAVAQALNFTRAAEKLHTSQPSLSSQIRDLENCVGVPLLVRDKRKVALTAA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ F + L +L + E + R I + + IGFVPSA LLP+++ FR P+ Sbjct: 61 GECFLQDALAILEQAENAKLRARKIVQ-EDRQLTIGFVPSAEVNLLPKVLPMFRLRQPDT 119 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 I ++T +Q E ++ G +DVG R P+ P+I + +EPLV V P+ HPL + Sbjct: 120 LIELVSLITTQQEEKIRRGELDVGLMRHPVYSPEIDYLELFDEPLVVVLPVDHPLAHEKE 179 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 +T AQL F+ S A V F+ +P+IV+ A + + LV G+GVT Sbjct: 180 ITAAQLDGVNFVSTDPAYSGSLAPIVKAWFAQENSQPNIVQVATNILVTMNLVGMGLGVT 239 Query: 241 LVPRSVQGLHRSDVVYRPLS------------NKGVHSPVIMNFRANDRSVLLERLRATA 288 L+P + + VV+RP++ KG P + +F A ++ ERL + Sbjct: 240 LIPGYMNNFNTGQVVFRPIAGNVPSIALLMAWKKGEMKPALRDFIA----IVQERLASVT 295 Query: 289 A 289 A Sbjct: 296 A 296 >ECs3403 [K] COG0583 Transcriptional regulator Ecs Escherichia coli O157:H7 Length = 296 Score = 181 bits (458), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 162/301 (53%), Gaps = 17/301 (5%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF AVA L+F+RAAE LH +QP LS QIR LE +GV L+ R R +ALT A Sbjct: 1 MELRHLRYFVAVAQALNFTRAAEKLHTSQPSLSSQIRDLENCVGVPLLVRDKRKVALTAA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ F + L +L + E + R I + + IGFVPSA LLP+++ FR P+ Sbjct: 61 GECFLQDALAILEQAENAKLRARKIVQ-EDRQLTIGFVPSAEVNLLPKVLPMFRLRQPDT 119 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 I ++T +Q E ++ G +DVG R P+ P+I + +EPLV V P+ HPL + Sbjct: 120 LIELVSLITTQQEEKIRRGELDVGLMRHPVYSPEIDYLELFDEPLVVVLPVDHPLAHEKE 179 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 +T AQL F+ S A V F+ +P+IV+ A + + LV G+GVT Sbjct: 180 ITAAQLDGVNFVSTDPAYSGSLAPIVKAWFAQENSQPNIVQVATNILVTMNLVGMGLGVT 239 Query: 241 LVPRSVQGLHRSDVVYRPLS------------NKGVHSPVIMNFRANDRSVLLERLRATA 288 L+P + + VV+RP++ KG P + +F A ++ ERL + Sbjct: 240 LIPGYMNNFNTGQVVFRPIAGNVPSIALLMAWKKGEMKPALRDFIA----IVQERLASVT 295 Query: 289 A 289 A Sbjct: 296 A 296 >hcaR [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 Length = 296 Score = 180 bits (457), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 162/301 (53%), Gaps = 17/301 (5%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF AVA L+F+RAAE LH +QP LS QIR LE +GV L+ R R +ALT A Sbjct: 1 MELRHLRYFVAVAQALNFTRAAEKLHTSQPSLSSQIRDLENCVGVPLLVRDKRKVALTAA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ F + L +L + E + R I + + IGFVPSA LLP+++ FR P+ Sbjct: 61 GECFLQDALAILEQAENAKLRARKIVQ-EDRQLTIGFVPSAEVNLLPKVLPMFRLRQPDT 119 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 I ++T +Q E ++ G +DVG R P+ P+I + +EPLV V P+ HPL + Sbjct: 120 LIELVSLITTQQEEKIRRGELDVGLMRHPVYSPEIDYLELFDEPLVVVLPVDHPLAHEKE 179 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 +T AQL F+ S A V F+ +P+IV+ A + + LV G+GVT Sbjct: 180 ITAAQLDGVNFVSTDPVYSGSLAPIVKAWFAQENSQPNIVQVATNILVTMNLVGMGLGVT 239 Query: 241 LVPRSVQGLHRSDVVYRPLS------------NKGVHSPVIMNFRANDRSVLLERLRATA 288 L+P + + VV+RP++ KG P + +F A ++ ERL + Sbjct: 240 LIPGYMNNFNTGQVVFRPIAGNVPSIALLMAWKKGEMKPALRDFIA----IVQERLASVT 295 Query: 289 A 289 A Sbjct: 296 A 296 >PA3594 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 295 Score = 166 bits (421), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 98/271 (36%), Positives = 150/271 (55%), Gaps = 6/271 (2%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 ++LR L+YF AVA L F RAA L I+QP LS I++LEE LG +L+ R ++ + LT A Sbjct: 1 MDLRQLRYFIAVAEELHFGRAAARLFISQPALSFDIKKLEEQLGTQLLLRNNKSVKLTGA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ + ++L + E+++ T++ A G +GFV S LY LP + RF E P + Sbjct: 61 GQVLLVEARNLLLQAEKVKRLTQLSAEGDVGQLRVGFVNSMLYRGLPRAMSRFEREHPNM 120 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGF---GRLPISDPDIVCETIEEEPLVAVFPLGHPLLA 177 E+ E+ + EQ +AL+ G+ID+GF GRLP +IV E + +P + P GH L Sbjct: 121 EVVLGEMNSAEQAQALQRGQIDLGFVHWGRLP---AEIVSEPLISDPFLCCLPAGHRLAG 177 Query: 178 RNKVTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGV 237 + ++ LA+L + FIL+P P Y D ++ P I EA QT +V G+ Sbjct: 178 QARLDLAELRDEDFILFPRHVSPHYHDLIIARCVDAGFSPRIRHEARLWQTVAAMVGLGM 237 Query: 238 GVTLVPRSVQGLHRSDVVYRPLSNKGVHSPV 268 GV L+P ++ R++V Y + G S + Sbjct: 238 GVALIPETLCLAWRNEVRYLEIEPAGARSEI 268 >PA5029 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 301 Score = 161 bits (408), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 106/284 (37%), Positives = 159/284 (55%), Gaps = 5/284 (1%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL+YF AVA L F RAAE L I+QPPLS+QI+ LEE +G L +R +R + LT A Sbjct: 1 MELRHLRYFIAVAEELHFGRAAERLGISQPPLSQQIQALEEEIGARLFERTNRRVELTDA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALY-GLLPEMIKRFRTEMPE 119 G+ F +++ VL+++++ R G+ IGF SA + +P I FR P+ Sbjct: 61 GRLFLDESRQVLAQVDKAVLLARRAHLGELGELKIGFTSSAPFTSTIPSSIHAFRKAYPD 120 Query: 120 IEIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIV-CETIEEEPLVAVFPLGHPLLA- 177 + + E+ + + ++AL + VG R P++ PD V + EPLVAV HPL A Sbjct: 121 VHLDLQEMSSRQVLKALLEESLQVGVIR-PLALPDAVHWVELFREPLVAVLRADHPLAAG 179 Query: 178 -RNKVTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAG 236 + + +A LA + F+ +P DQV+ + P I +EA+E T IGLV+AG Sbjct: 180 SEDGLAIAALAEEPFVFFPRSYGTGLYDQVIALTRQAGFSPRIAQEASEAMTIIGLVSAG 239 Query: 237 VGVTLVPRSVQGLHRSDVVYRPLSNKGVHSPVIMNFRANDRSVL 280 +GV+++P S + VVYR LS+ + V + R N+ S L Sbjct: 240 LGVSILPASFRRTRVDGVVYRTLSDPEATTAVWLVRRQNEGSPL 283 >PA5218 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 304 Score = 161 bits (407), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 104/285 (36%), Positives = 148/285 (51%), Gaps = 3/285 (1%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 ++LR L+ F AVA TL F RAA+ LH+AQPPL+RQI LEE LG L DR+SR + LT Sbjct: 2 LDLRRLRCFAAVAETLHFGRAAQRLHMAQPPLTRQISALEEELGFRLFDRSSRAVTLTAE 61 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPS-ALYGLLPEMIKRFRTEMPE 119 G F +L +LE+ R +A+G +G+ S AL L E I+ FR PE Sbjct: 62 GSLFLPYARALLDQLERTAGFARKLAQGLAGHLTLGYASSIALSDLFTEAIRLFRERHPE 121 Query: 120 IEIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIE--EEPLVAVFPLGHPLLA 177 +++ E + Q + G IDVG GRLP + + E + EPLV P G PL Sbjct: 122 VQLELLEGASAAQWAQIAEGGIDVGLGRLPPPEGQVGIEVLALGGEPLVVAVPNGDPLAR 181 Query: 178 RNKVTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGV 237 + ++ L L + IL+P + + ++ L + ++ + I LVAAG Sbjct: 182 QERIDLYDLRDRPLILFPLDYGSGLNELIERLYRKAGLALTRGPAGRQITSIIALVAAGQ 241 Query: 238 GVTLVPRSVQGLHRSDVVYRPLSNKGVHSPVIMNFRANDRSVLLE 282 GV LVPR L R+ VVYRPL+ + ++ R + RS +E Sbjct: 242 GVALVPRCSTALARAGVVYRPLAEPEALADFLVFTRRHGRSAAVE 286 >DR0615 [K] COG0583 Transcriptional regulator Dra Deinococcus radiodurans Length = 317 Score = 160 bits (404), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 104/269 (38%), Positives = 148/269 (55%), Gaps = 4/269 (1%) Query: 1 VELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMA 60 +ELRHL++F A+A F RAAE + + Q LS IR LEE +GV+L+ R +R + LT A Sbjct: 1 MELRHLRHFVALAEEEHFGRAAERVFVVQQALSSSIRNLEEEVGVQLVTRTTRRVQLTPA 60 Query: 61 GKFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALYGLLPEMIKRFRTEMPEI 120 G+ F L++ Q E R A+G+ +GFV +G LPE+++RFR P + Sbjct: 61 GEEFLIGARATLAQAAQTVERARRAAQGEVGRLTVGFVSGLAFGGLPEIVRRFRELYPAV 120 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPDIVCETIEEEPLVAVFPLGHPLLARNK 180 + E+ EQ AL+ G+IDVG LP+ DP + + PLVA P HPL +R Sbjct: 121 SVDLRELTAGEQEAALRGGQIDVGLLLLPVRDPALASRPLWRLPLVAALPAAHPLASRTT 180 Query: 181 VTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGVT 240 + + L+ + F+ +P R +Y DQV+ + P +V+EA E+ T + LVAAGVGV Sbjct: 181 LRIGDLSQEDFVFFPRYLRATYFDQVMHWCADAGFTPHVVQEAIEIPTLLSLVAAGVGVF 240 Query: 241 LVPRSVQGLHRSDVVYRPLSNKGVHSPVI 269 L L VVYRPL +PVI Sbjct: 241 LPIEFFARLALPGVVYRPLEG----APVI 265 >AGl1663 [K] COG0583 Transcriptional regulator Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 309 Score = 156 bits (395), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 96/279 (34%), Positives = 142/279 (50%), Gaps = 2/279 (0%) Query: 2 ELRHLKYFNAVASTLSFSRAAELLHIAQPPLSRQIRQLEEMLGVELIDRASRPIALTMAG 61 ELRHL+YF + +F RAA L IAQP LS+QI LE+++G+ L+DR R + LT +G Sbjct: 19 ELRHLRYFTTLVDERNFERAAARLGIAQPGLSQQIMALEDIVGMPLLDRTRRSVKLTTSG 78 Query: 62 KFFYEQTLHVLSRLEQIEEGTRVIARGQQHWFNIGFVPSALY-GLLPEMIKRFRTEMPEI 120 + YE +L+ E R + RG+ +IG+V SA Y GLL + I FR P++ Sbjct: 79 QLLYEDARKILANAEAALASLRRVGRGETGRISIGYVASAAYSGLLIQSIASFRASHPDV 138 Query: 121 EIGFSEIVTMEQVEALKSGRIDVGFGRLPISDPD-IVCETIEEEPLVAVFPLGHPLLARN 179 E+ E+ Q+ + G +D F R P P+ + + EPL+A P HPL Sbjct: 139 ELQLIEMEMRLQLAKIADGNLDFAFIRPPAPIPEGVATHVVLREPLMAALPENHPLAYAL 198 Query: 180 KVTLAQLAAQRFILYPARPRPSYADQVLDIFSSRALRPSIVKEANEMQTAIGLVAAGVGV 239 ++ L LAA+ FI P + ++ + +P I E + T +VA G+GV Sbjct: 199 QLDLKNLAAETFITPRQPPDVGFHYNTIEACNEAGFQPVISPEGRDYTTITSMVAIGLGV 258 Query: 240 TLVPRSVQGLHRSDVVYRPLSNKGVHSPVIMNFRANDRS 278 LVPRS+ L V Y PL+ S + + R + S Sbjct: 259 ALVPRSLDCLRLPGVRYVPLAASATTSDLAIAHRKTEAS 297