BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0460.p (226 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0947 [IQR] COG1028 Dehydrogenases with different specificitie... 338 7e-93 YPO2539 [IQR] COG1028 Dehydrogenases with different specificitie... 277 1e-74 mlr3785 [IQR] COG1028 Dehydrogenases with different specificitie... 274 9e-74 AGl1541 [IQR] COG1028 Dehydrogenases with different specificitie... 268 8e-72 SMa0513 [IQR] COG1028 Dehydrogenases with different specificitie... 266 2e-71 SMb20692 [IQR] COG1028 Dehydrogenases with different specificiti... 263 2e-70 idnO [IQR] COG1028 Dehydrogenases with different specificities (... 260 1e-69 STM4483 [IQR] COG1028 Dehydrogenases with different specificitie... 256 4e-68 AGc2598 [IQR] COG1028 Dehydrogenases with different specificitie... 233 3e-61 CAC2607 [IQR] COG1028 Dehydrogenases with different specificitie... 201 8e-52 >RSp0947 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 258 Score = 338 bits (866), Expect = 7e-93, Method: Compositional matrix adjust. Identities = 159/226 (70%), Positives = 186/226 (82%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +A+AGA +VLN R KLA A LRA+G +H ++FD T S V + ++E+E+G I Sbjct: 33 LARAGARVVLNARGPEKLAQAADSLRAQGADVHTAAFDVTQSTAVAEGIARVEAELGPID 92 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAG+QRR PLE+F+ WH+L+ TN++SVF QAVAR+MIPRG GKIINICSVQS Sbjct: 93 ILVNNAGMQRRAPLEQFETDQWHELMKTNVDSVFLVGQAVARYMIPRGRGKIINICSVQS 152 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 ELGRPGIAPYTA+KGAVKM TKGMAIDWG +G+QVNGLGPGYFKTE+ ALV +A+FT W Sbjct: 153 ELGRPGIAPYTASKGAVKMLTKGMAIDWGPHGLQVNGLGPGYFKTELTQALVANAEFTAW 212 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 LVGRTPSRRWGDVEDL GAA+FLAS AS FVNGHILYVDGGVTATL Sbjct: 213 LVGRTPSRRWGDVEDLTGAAIFLASKASDFVNGHILYVDGGVTATL 258 >YPO2539 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 254 Score = 277 bits (708), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 127/222 (57%), Positives = 166/222 (74%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +A+ GA I++N A + A+LRA G H ++F+ T+ +EV A++KIES IG+I Sbjct: 29 LAEFGAEIIINDITAERAEKAVAELRASGFIAHAAAFNVTNHDEVNEAIEKIESHIGAID 88 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 +L+NNAGIQRR+ EF E DW D+I+ N SVF +QAVAR+M+ R GKIINICS+QS Sbjct: 89 VLINNAGIQRRHAFTEFPEKDWDDVIAVNQKSVFLVSQAVARYMVKRQRGKIINICSMQS 148 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 ELGR I PY A+KGAVKM T+GM ++ +Y IQVNG+ PGYFKT+M ALV+D FTDW Sbjct: 149 ELGRDTITPYAASKGAVKMLTRGMCVELARYNIQVNGIAPGYFKTDMTKALVDDQAFTDW 208 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGV 222 L RTP+ RWGD E+L+GAAV+L+S AS FVNGH+L+VDGG+ Sbjct: 209 LCKRTPAARWGDPEELIGAAVYLSSKASDFVNGHLLFVDGGM 250 >mlr3785 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 251 Score = 274 bits (701), Expect = 9e-74, Method: Compositional matrix adjust. Identities = 137/226 (60%), Positives = 162/226 (71%), Gaps = 4/226 (1%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +AQAGA+++LNGRD KLAA AAQ+ +FDAT + V+ A+ E G I Sbjct: 30 LAQAGASVILNGRDTAKLAATAAQIPGA----QTLAFDATEHDAVRSAIDNFELSGGPID 85 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAG+Q R PLE+F + L+ TN+ SVF QAVARHMI RG GKIINI SVQ+ Sbjct: 86 ILVNNAGMQFRTPLEDFPADAFERLLQTNVASVFHVGQAVARHMIRRGRGKIINIASVQT 145 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 L RPGIAPYTATKGAV TKGMA DW K+G+Q N + PGYF T +N ALV D F+ W Sbjct: 146 ALARPGIAPYTATKGAVGNLTKGMATDWAKHGLQCNAIAPGYFDTPLNAALVADPAFSGW 205 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 L RTP+ RWG VE+LVGA VFLASDAS FVNGHILYVDGG+TA++ Sbjct: 206 LEKRTPAGRWGKVEELVGACVFLASDASSFVNGHILYVDGGITASI 251 >AGl1541 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 298 Score = 268 bits (685), Expect = 8e-72, Method: Compositional matrix adjust. Identities = 134/226 (59%), Positives = 162/226 (71%), Gaps = 4/226 (1%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +++AGA +VLNGRD KL A AA + +FDAT V+ A+ + E+E+G+I Sbjct: 77 LSEAGAEVVLNGRDEAKLKAAAAGI----KGARTLAFDATDHGAVREAIDRFEAEVGAID 132 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAG+Q R PLE+F + L+ TN+ SVF QA ARHMI RG GKIINI SVQ+ Sbjct: 133 ILVNNAGMQHRTPLEDFPADAFERLLQTNIASVFHVGQATARHMISRGRGKIINIASVQT 192 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 L RPGIAPYTATKGAV TKGMA DW KYG+Q N + PGYF T +N ALV D F+ W Sbjct: 193 ALARPGIAPYTATKGAVGNLTKGMATDWAKYGLQCNAIAPGYFDTPLNAALVADETFSAW 252 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 L RTP+ RWG VE+LVGA +FL+SDAS FVNGHILYVDGG+TA+L Sbjct: 253 LEKRTPAGRWGKVEELVGACIFLSSDASSFVNGHILYVDGGITASL 298 >SMa0513 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 251 Score = 266 bits (681), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 141/226 (62%), Positives = 170/226 (75%), Gaps = 4/226 (1%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +A GA I+LNGRDA KLAA A L A GHT+ +FDAT + V+ AV E+++G+I Sbjct: 30 LAATGAEIILNGRDAAKLAAAARDLGA-GHTL---AFDATDHQAVRKAVDAFEADVGAID 85 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAG+Q R PLE+F + L+ TN++SVF QAVARHMI RGAGKIINI SVQ+ Sbjct: 86 ILVNNAGMQHRTPLEDFPADAFERLLKTNVSSVFNVGQAVARHMIKRGAGKIINIASVQT 145 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 L RPGIAPYTATKGAV TKGMA DW +YG+Q N + PGYF T +N ALV D F+DW Sbjct: 146 ALARPGIAPYTATKGAVGNLTKGMATDWARYGLQCNAIAPGYFDTPLNAALVADPSFSDW 205 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 L RTP+ RWG VE+LVGA +FL+SDAS FVNGH+LYVDGG+TA+L Sbjct: 206 LERRTPAGRWGKVEELVGACIFLSSDASSFVNGHVLYVDGGITASL 251 >SMb20692 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 268 Score = 263 bits (673), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 137/226 (60%), Positives = 162/226 (71%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 + +AGA+++LNGRD +LA A+L G T+ S+FD T S E+ AV I +E G I Sbjct: 43 LCEAGASVILNGRDEARLAGARAELEEHGFTVGTSAFDVTKSAEIGRAVADILAERGRID 102 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAGIQ R PL EF E + +I TNL S F QAV + MI R G IINICSVQS Sbjct: 103 ILVNNAGIQHRTPLHEFPEDAFRRVIETNLTSAFLVGQAVVQGMIERREGTIINICSVQS 162 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 EL RP IAPY A+KG +KM TKGMA+DWG+YGI+VNGL PGYFKTE+N ALV+D KF+ W Sbjct: 163 ELARPSIAPYAASKGGLKMLTKGMALDWGRYGIRVNGLAPGYFKTELNSALVSDEKFSTW 222 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 L RTP RWGD +L AAVFLAS AS FV GHILYVDGG+T+ L Sbjct: 223 LEQRTPLGRWGDTGELAAAAVFLASAASSFVTGHILYVDGGITSCL 268 >idnO [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Eco Escherichia coli K12 Length = 254 Score = 260 bits (665), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 120/222 (54%), Positives = 157/222 (70%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 + + GA I++N A + +L EG + F+ T E+ AV+ IE +IG I Sbjct: 29 LGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHIEKDIGPID 88 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 +LVNNAGIQRR+P EF E +W+D+I+ N +VF +QAV RHM+ R AGK+INICS+QS Sbjct: 89 VLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQS 148 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 ELGR I PY A+KGAVKM T+GM ++ ++ IQVNG+ PGYFKTEM ALV D FT W Sbjct: 149 ELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGIAPGYFKTEMTKALVEDEAFTAW 208 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGV 222 L RTP+ RWGD ++L+GAAVFL+S AS FVNGH+L+VDGG+ Sbjct: 209 LCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHLLFVDGGM 250 >STM4483 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sty Salmonella typhimurium LT2 Length = 254 Score = 256 bits (653), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 116/222 (52%), Positives = 158/222 (71%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 + + GA I++N + +L+ EG + F+ T ++++ AV+ IE +IG I Sbjct: 29 LGRYGARIIVNDITPERAETAVTKLQQEGIKAIAAPFNVTHKQDIEAAVEHIEKDIGVID 88 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 +L+NNAGIQRR+P EF E +W+D+I+ N +VF +QAV R M+ R AGK+INICS+QS Sbjct: 89 VLINNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRRMVARQAGKVINICSMQS 148 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 ELGR I PY A+KGAVKM T+GM ++ ++ IQVNG+ PGYFKTEM ALV D FT W Sbjct: 149 ELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGIAPGYFKTEMTKALVEDEAFTSW 208 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGV 222 L RTP+ RWGD ++L+GAAVFL+S AS FVNGH+L+VDGG+ Sbjct: 209 LCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHLLFVDGGM 250 >AGc2598 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 256 Score = 233 bits (594), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 107/226 (47%), Positives = 150/226 (66%) Query: 1 MAQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIG 60 +A AGA I++NG D ++A + R GH +FD TS E+ A +++ + + Sbjct: 31 LAVAGARILINGTDPSRVAQTVQEFRNVGHDAEAVAFDVTSESEIIEAFARLDEQGIDVD 90 Query: 61 ILVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQS 120 ILVNNAGIQ R P+ E + +DW +I TNL S F + A+ MIPRG GKI+NI S+ S Sbjct: 91 ILVNNAGIQFRKPMIELETADWQRVIDTNLTSAFMIGREAAKRMIPRGYGKIVNIGSLTS 150 Query: 121 ELGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALVNDAKFTDW 180 EL R +APYT KG +KM T+ MA +W +YGIQ N +GPGY T+MN AL+++ +F W Sbjct: 151 ELARATVAPYTVAKGGIKMLTRAMAAEWAQYGIQANAIGPGYMLTDMNQALIDNPEFDAW 210 Query: 181 LVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 + RTP++RWG ++LVG AVFL++ AS +VNG I+YVDGG+ + L Sbjct: 211 VKARTPAKRWGKPQELVGTAVFLSASASDYVNGQIIYVDGGMLSVL 256 >CAC2607 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 267 Score = 201 bits (512), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 105/231 (45%), Positives = 142/231 (61%), Gaps = 6/231 (2%) Query: 2 AQAGAAIVLNGRDAGKLAAVAAQLRAEGHTIHESSFDATSSEEVKVAVQKIESEIGSIGI 61 A AGA IV N + + AEG H D T ++V V+K+E E+G I I Sbjct: 32 ANAGATIVFNDINQDLVDKGLKAYEAEGIKAHGYVCDVTDEDKVNGFVKKVEKEVGLIDI 91 Query: 62 LVNNAGIQRRNPLEEFKESDWHDLISTNLNSVFFAAQAVARHMIPRGAGKIINICSVQSE 121 LVNNAGI +R P+ E K D+ +I +LN+ F ++AV MI +G GKIINICS+ SE Sbjct: 92 LVNNAGIIKRIPMLEMKAEDFRKVIDVDLNAPFIVSKAVIPGMIKKGHGKIINICSMMSE 151 Query: 122 LGRPGIAPYTATKGAVKMFTKGMAIDWGKYGIQVNGLGPGYFKTEMNMALV------NDA 175 LGR ++ Y A KG +KM T+ +A ++G++ IQ NG+GPGY T L + Sbjct: 152 LGRETVSAYAAAKGGLKMLTRNIASEYGEHNIQCNGIGPGYIATPQTAPLRELQADGSKH 211 Query: 176 KFTDWLVGRTPSRRWGDVEDLVGAAVFLASDASRFVNGHILYVDGGVTATL 226 F +++ +TP+ RWG EDL+G AVFLASDAS FVNGH+LYVDGG+ A + Sbjct: 212 PFDQFIIAKTPAARWGTPEDLMGPAVFLASDASNFVNGHVLYVDGGILAYI 262