BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0441.p (249 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll5766 [IQR] COG1028 Dehydrogenases with different specificitie... 315 5e-86 SMc00268 [IQR] COG1028 Dehydrogenases with different specificiti... 289 4e-78 YPO1599 [IQR] COG1028 Dehydrogenases with different specificitie... 166 6e-41 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 166 6e-41 fabG [IQR] COG1028 Dehydrogenases with different specificities (... 163 3e-40 ZfabG [IQR] COG1028 Dehydrogenases with different specificities ... 162 5e-40 ECs1471 [IQR] COG1028 Dehydrogenases with different specificitie... 162 5e-40 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 162 6e-40 HI0155 [IQR] COG1028 Dehydrogenases with different specificities... 160 3e-39 VC2021 [IQR] COG1028 Dehydrogenases with different specificities... 159 8e-39 >mll5766 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 250 Score = 315 bits (808), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 158/249 (63%), Positives = 192/249 (77%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 MLLK K VI+G A G+G +TA LMAEQGAR+ +LDL + AAA +G +H+GL Sbjct: 1 MLLKGKAVVISGAASPRGIGRSTATLMAEQGARIAILDLDEEQARDAAASLGPEHIGLAC 60 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +V D SC AAA + + FGR+++L N AGITQPVKTL+I AD+DRILDV+LRG LY+S Sbjct: 61 NVADLDSCKRAAAEVTEAFGRVEVLCNIAGITQPVKTLDIGPADWDRILDVNLRGVLYLS 120 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 QA +P MR GSIIC+SSVSAQRGGGI GGPHYSAAKAGVLGLA+AMAREFGP+GIR+ Sbjct: 121 QAFIPHMRENGGGSIICMSSVSAQRGGGIFGGPHYSAAKAGVLGLAKAMAREFGPDGIRI 180 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N +TPGLI TDI GKLT+ +A+I + IPL+RLG A D+ GA +FL SDL+ Y TG + Sbjct: 181 NCVTPGLIQTDITGGKLTDAMRADIIKGIPLSRLGDARDVAGAYLFLASDLASYITGAVI 240 Query: 241 DVNGGMLIH 249 DVNGGMLIH Sbjct: 241 DVNGGMLIH 249 >SMc00268 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 252 Score = 289 bits (739), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 152/248 (61%), Positives = 182/248 (73%) Query: 2 LLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVAD 61 LL+ AVITG A GLG ATARL AE GA V +LDL +AD AAA +G +H+G+ + Sbjct: 5 LLEGNFAVITGAASRRGLGKATARLFAEHGATVAILDLDEADAREAAASLGPRHVGMACN 64 Query: 62 VTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMSQ 121 VTD AS T A++ Q+GRIDILVNNAGITQP+K +EI +YD +LDV+LRGTLY SQ Sbjct: 65 VTDLASVRTVMDALVSQWGRIDILVNNAGITQPLKIMEIAPENYDAVLDVNLRGTLYCSQ 124 Query: 122 AVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRVN 181 AV+P MR+++ G I+ +SSVSAQRGGGI GGPHYSAAKAGVLGL +AMARE P+ +RVN Sbjct: 125 AVIPHMRSRKQGKIVNLSSVSAQRGGGIFGGPHYSAAKAGVLGLTKAMARELAPDNVRVN 184 Query: 182 SITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITLD 241 +I PG I TDI G LT EK EI IP+ R G ADD+ G +FL SDLS Y TG +D Sbjct: 185 AICPGFIATDITGGLLTPEKLEEIKAGIPMGRPGTADDVAGCALFLASDLSAYVTGSEVD 244 Query: 242 VNGGMLIH 249 VNGG LIH Sbjct: 245 VNGGSLIH 252 >YPO1599 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 244 Score = 166 bits (419), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 98/248 (39%), Positives = 146/248 (58%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 M + K+A++TG + G+G A A L+ E+GA V+ ++ A +A +G GL+ Sbjct: 1 MSFEGKIALVTGAS--RGIGRAIAELLVERGACVIGTATSEKGAEAISAYLGENGKGLML 58 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +V D S DT A I +FG +DILVNNAGIT+ + + ++ I+D +L +S Sbjct: 59 NVVDPTSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRLS 118 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 +AV+ AM ++ G II I SV G G +Y+AAKAGV+G ++++ARE GI V Sbjct: 119 KAVMRAMMKKRFGRIITIGSVVGTMGNA--GQVNYAAAKAGVIGFSKSLAREVASRGITV 176 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N + PG I TD+ + LT++++A I +P RLG A +I A FL SD + Y +G TL Sbjct: 177 NVVAPGFIETDMTR-TLTDDQRAGILAQVPANRLGDAKEIASAVAFLASDEASYISGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 166 bits (419), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 100/251 (39%), Positives = 145/251 (57%), Gaps = 9/251 (3%) Query: 2 LLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPA----AAAARIGSQHLG 57 +L+ K A++TG + G+G ATA +A GA VVV + A A +G + + Sbjct: 1 MLQGKTAIVTGAS--RGIGRATAMELARHGANVVVNYAGNKEKAEKVVAEIKELGVEAIA 58 Query: 58 LVADVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTL 117 + ADV D S + FG +DILVNNAGIT+ + + D+D ++D +L+G Sbjct: 59 IQADVADSESVQAMVKETIDTFGAVDILVNNAGITRDNLFMRMKEEDWDAVIDTNLKGVF 118 Query: 118 YMSQAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEG 177 + S+AV M Q+ G II +SSV G G +Y AAKAGV+GL + +ARE Sbjct: 119 HCSKAVTRPMMKQRFGRIINVSSVVGAIGNA--GQANYVAAKAGVIGLTKTLARELANRN 176 Query: 178 IRVNSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTG 237 I VN++ PG I TD+ G+L E+ KA++ IPLARLG+ +++ A FL SD + Y TG Sbjct: 177 ITVNAVAPGFIETDMT-GELPEDVKAQMLGQIPLARLGQPEEVAKAVRFLASDDASYLTG 235 Query: 238 ITLDVNGGMLI 248 T+ VNGGM++ Sbjct: 236 QTIHVNGGMVM 246 >fabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Eco Escherichia coli K12 Length = 244 Score = 163 bits (413), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 94/248 (37%), Positives = 150/248 (60%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 M + K+A++TG + G+G A A +A +GA+V+ ++ A + +G+ GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +VTD AS ++ I +FG +DILVNNAGIT+ + + +++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 +AV+ AM +++G II I SV G G G +Y+AAKAG++G ++++ARE GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N + PG I TD+ + L+++++A I +P RLG A +I A FL SD + Y TG TL Sbjct: 177 NVVAPGFIETDMTRA-LSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >ZfabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) EcZ Escherichia coli O157:H7 EDL933 Length = 244 Score = 162 bits (411), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 94/248 (37%), Positives = 150/248 (60%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 M + K+A++TG + G+G A A +A +GA+V+ ++ A + +G+ GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +VTD AS ++ I +FG +DILVNNAGIT+ + + +++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 +AV+ AM +++G II I SV G G G +Y+AAKAG++G ++++ARE GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N + PG I TD+ + L+++++A I +P RLG A +I A FL SD + Y TG TL Sbjct: 177 NVVAPGFIETDMTRA-LSDDQRAGILVQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >ECs1471 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ecs Escherichia coli O157:H7 Length = 244 Score = 162 bits (411), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 94/248 (37%), Positives = 150/248 (60%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 M + K+A++TG + G+G A A +A +GA+V+ ++ A + +G+ GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +VTD AS ++ I +FG +DILVNNAGIT+ + + +++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 +AV+ AM +++G II I SV G G G +Y+AAKAG++G ++++ARE GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N + PG I TD+ + L+++++A I +P RLG A +I A FL SD + Y TG TL Sbjct: 177 NVVAPGFIETDMTRA-LSDDQRAGILVQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 162 bits (411), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 93/254 (36%), Positives = 151/254 (59%), Gaps = 14/254 (5%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADP---AAAAARIGSQHLG 57 M L+ KV +ITG A +G+G AT L A++GA V+ D+++ + A + + Sbjct: 1 MRLEGKVCLITGAA--SGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDP 58 Query: 58 LVADVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTL 117 V +VTD+ ++Q++GRID+LVNNAGIT+ + + D+D +++V+L+G Sbjct: 59 YVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVF 118 Query: 118 YMSQAVLPAMRAQQNGSIICISSVSAQRGGGILGGP---HYSAAKAGVLGLARAMAREFG 174 ++Q V+P M Q+NGSI+ +SSV GI G P +Y+A+KAGV+G+ + A+E Sbjct: 119 NVTQMVVPYMIKQRNGSIVNVSSVV-----GIYGNPGQTNYAASKAGVIGMTKTWAKELA 173 Query: 175 PEGIRVNSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQY 234 IRVN++ PG I T + + KL E+ + IPL R G+ +++ +FL SD S Y Sbjct: 174 GRNIRVNAVAPGFIETPMTE-KLPEKARETALSRIPLGRFGKPEEVAQVILFLASDESSY 232 Query: 235 CTGITLDVNGGMLI 248 TG + ++GG++I Sbjct: 233 VTGQVIGIDGGLVI 246 >HI0155 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Hin Haemophilus influenzae Length = 242 Score = 160 bits (405), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 97/246 (39%), Positives = 144/246 (58%), Gaps = 5/246 (2%) Query: 3 LKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVADV 62 ++ K+A++TG G+G A A ++ +GA V+ ++ A +A +G + GLV +V Sbjct: 1 MQGKIALVTGST--RGIGRAIAEELSSKGAFVIGTATSEKGAEAISAYLGDKGKGLVLNV 58 Query: 63 TDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMSQA 122 TDK S +T I FG IDILVNNAGIT+ + + ++ I+ +L ++S+A Sbjct: 59 TDKESIETLLEQIKNDFGDIDILVNNAGITRDNLLMRMKDEEWFDIMQTNLTSVYHLSKA 118 Query: 123 VLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRVNS 182 +L +M ++ G II I SV G G +Y AAKAGV+G ++++A+E GI VN Sbjct: 119 MLRSMMKKRFGRIINIGSVVGSTGNP--GQTNYCAAKAGVVGFSKSLAKEVAARGITVNV 176 Query: 183 ITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITLDV 242 + PG I TD+ + LT+E+KA I +P RLG A DI A FL SD + Y TG TL V Sbjct: 177 VAPGFIATDMTE-VLTDEQKAGILSNVPAGRLGEAKDIAKAVAFLASDDAGYITGTTLHV 235 Query: 243 NGGMLI 248 NGG+ + Sbjct: 236 NGGLYL 241 >VC2021 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Vch Vibrio cholerae Length = 248 Score = 159 bits (401), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 94/248 (37%), Positives = 144/248 (58%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAVITGGAGINGLGYATARLMAEQGARVVVLDLAQADPAAAAARIGSQHLGLVA 60 M L+ KVA++TG + G+G A A L+AE+GA+V+ +++ A + +G G+ Sbjct: 5 MNLEGKVALVTGAS--RGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMAL 62 Query: 61 DVTDKASCDTAAAAILQQFGRIDILVNNAGITQPVKTLEITGADYDRILDVSLRGTLYMS 120 +VT+ S + AI +FG +DILVNNAGIT+ + + ++ I++ +L +S Sbjct: 63 NVTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLS 122 Query: 121 QAVLPAMRAQQNGSIICISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPEGIRV 180 +AVL M ++ G II + SV G G +Y+AAKAGV+G ++MARE G+ V Sbjct: 123 KAVLRGMMKKRQGRIINVGSVVGTMGNA--GQANYAAAKAGVIGFTKSMAREVASRGVTV 180 Query: 181 NSITPGLIGTDIIKGKLTEEKKAEIAETIPLARLGRADDIGGACVFLGSDLSQYCTGITL 240 N++ PG I TD+ K E++ A +A+ +P RLG +I A FL S + Y TG TL Sbjct: 181 NTVAPGFIETDMTKALNDEQRTATLAQ-VPAGRLGDPREIASAVAFLASPEAAYITGETL 239 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 240 HVNGGMYM 247