BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0392.p (322 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Z3395 [K] COG0583 Transcriptional regulator EcZ Escherichia coli... 122 1e-27 ECs3032 [K] COG0583 Transcriptional regulator Ecs Escherichia co... 122 1e-27 VCA0542 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae 106 8e-23 ydcI [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 105 2e-22 Z2299 [K] COG0583 Transcriptional regulator EcZ Escherichia coli... 103 6e-22 ECs2027 [K] COG0583 Transcriptional regulator Ecs Escherichia co... 103 6e-22 CAC3361 [K] COG0583 Transcriptional regulator Cac Clostridium ac... 101 2e-21 PA2469 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 100 7e-21 STM2180 [K] COG0583 Transcriptional regulator Sty Salmonella typ... 100 8e-21 STM1625 [K] COG0583 Transcriptional regulator Sty Salmonella typ... 98 2e-20 >Z3395 [K] COG0583 Transcriptional regulator EcZ Escherichia coli O157:H7 EDL933 Length = 318 Score = 122 bits (306), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 138/280 (49%), Gaps = 2/280 (0%) Query: 2 SFNLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTV 61 L LEM A+ G+L A ++N+TQPALS+ + +LE+ +G LFERH+KG+ T Sbjct: 23 KLKLHHLEMLVALGEQGNLTHVARMMNITQPALSKWLSQLEDEIGITLFERHSKGLRPTE 82 Query: 62 LGQALLPHAMSLQREAQQAREELDAIR-GLAKGVIKVGAVGSIASLVLPLAVRGVLDKWP 120 G+ LL HA L + ++++ EL + G G +K+G +A+ + A+ +L K P Sbjct: 83 GGKLLLQHAQRLINDMERSQHELARFKQGGLVGSLKIGC-SPVATDCVSQAILHLLTKMP 141 Query: 121 NLRVEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLR 180 L + I E V L++ LL +D+ + GG+ + +T+ VA P+HPL Sbjct: 142 TLHLNIEEKVMTPLLQDLLAGSVDVVVGRIGGRALQLPLNYQVLYTEPVCFVARPEHPLA 201 Query: 181 QQGRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCG 240 + ++ RW + P GT + + HG+ +PE +ES S+ V +L+ Sbjct: 202 KYATLSWNDLANWRWIVWPTGTPIRISIDNALVDHGVMLPENTIESASMNVSTNLLQSSD 261 Query: 241 FIGWMSGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQ 280 I +S + G +V L + ++ ++ F R Sbjct: 262 MISILSLRLAQRYASQGQLVILNLPKIEQKGSVGVFWRNN 301 >ECs3032 [K] COG0583 Transcriptional regulator Ecs Escherichia coli O157:H7 Length = 318 Score = 122 bits (306), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 138/280 (49%), Gaps = 2/280 (0%) Query: 2 SFNLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTV 61 L LEM A+ G+L A ++N+TQPALS+ + +LE+ +G LFERH+KG+ T Sbjct: 23 KLKLHHLEMLVALGEQGNLTHVARMMNITQPALSKWLSQLEDEIGITLFERHSKGLRPTE 82 Query: 62 LGQALLPHAMSLQREAQQAREELDAIR-GLAKGVIKVGAVGSIASLVLPLAVRGVLDKWP 120 G+ LL HA L + ++++ EL + G G +K+G +A+ + A+ +L K P Sbjct: 83 GGKLLLQHAQRLINDMERSQHELARFKQGGLVGSLKIGC-SPVATDCVSQAILHLLTKMP 141 Query: 121 NLRVEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLR 180 L + I E V L++ LL +D+ + GG+ + +T+ VA P+HPL Sbjct: 142 TLHLNIEEKVMTPLLQDLLAGSVDVVVGRIGGRALQLPLNYQVLYTEPVCFVARPEHPLA 201 Query: 181 QQGRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCG 240 + ++ RW + P GT + + HG+ +PE +ES S+ V +L+ Sbjct: 202 KYATLSWNDLANWRWIVWPTGTPIRISIDNALVDHGVMLPENTIESASMNVSTNLLQSSD 261 Query: 241 FIGWMSGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQ 280 I +S + G +V L + ++ ++ F R Sbjct: 262 MISILSLRLAQRYASQGQLVILNLPKIEQKGSVGVFWRNN 301 >VCA0542 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae Length = 301 Score = 106 bits (264), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 144/278 (51%), Gaps = 8/278 (2%) Query: 3 FNLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVL 62 ++L+QL +F+A+ GS+ +AA L LTQ A S ++ +LE+ +G LFER K M LT Sbjct: 3 YSLKQLAVFDAVADCGSVSQAADKLALTQSATSMSLAQLEKMLGRPLFERQGKQMALTHW 62 Query: 63 GQALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNL 122 G L P A L ++AQQ + L G I++GA + A ++P + + +P + Sbjct: 63 GMWLRPKAKRLLQDAQQIEMGF-YDQHLLSGEIRLGASQTPAEHLVPDLISIIDSDFPEI 121 Query: 123 RVEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQ 182 R+ + ++EG+L ++ DL + G+ + + D +VA+ HP ++ Sbjct: 122 RISLGVKSTKGVIEGVLDYKYDLGIIE--GRCDDNRIYQEVWCRDHLTIVASAHHPFAKR 179 Query: 183 GRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGFI 242 ++L Q +W L +G G ++ ++ +P ++ E V VL++LVA ++ Sbjct: 180 ESVSLAQLEQAKWVLREQGAGTR-NIFDSVIHPLIPDLDVWREYEHVPVLRTLVANGPYL 238 Query: 243 GWMSGPMFDTER--QAGVIVALEVAGLDAPRTLTAFRR 278 + P D ER ++G++VAL V L+ RTL+ R Sbjct: 239 TCL--PYLDVERFIESGLLVALNVPELNMERTLSFIWR 274 >ydcI [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 Length = 354 Score = 105 bits (261), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 80/292 (27%), Positives = 135/292 (46%), Gaps = 3/292 (1%) Query: 5 LQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVLGQ 64 L+ L F A+ G+LGRAA LNL+QPALS+ + LE+ G LFER +G LT+ G+ Sbjct: 60 LRHLHTFVAVAQQGTLGRAAETLNLSQPALSKTLNELEQLTGARLFERGRQGAQLTLPGE 119 Query: 65 ALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNLRV 124 L HA+ + A L GL V++VGA+ + A +LP + + + Sbjct: 120 QFLTHAVRVLDAINTAGRSLHRKEGLNNDVVRVGALPTAALGILPSVIGQFHQQQKETTL 179 Query: 125 EIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQGR 184 ++ ++ GL T EID+ + + + + +V P+HPL Q+ Sbjct: 180 QVATMSNPMILAGLKTGEIDIGIGRMSDPELMTGLNYELLFLESLKLVVRPNHPLLQEN- 238 Query: 185 IALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGFIGW 244 + L + L ++P+GT P H G +P +E+ S ++ + L ++ + Sbjct: 239 VTLSRVLEWPVVVSPEGTAPRQHSDALVQSQGCKIPSGCIETLSASLSRQLTVEYDYVWF 298 Query: 245 M-SGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQGILPAPAARLLDELR 295 + SG + D R A +VAL V G A + R + +++ +R Sbjct: 299 VPSGAVKDDLRHA-TLVALPVPGHGAGEPIGILTRVDATFSSGCQLMINAIR 349 >Z2299 [K] COG0583 Transcriptional regulator EcZ Escherichia coli O157:H7 EDL933 Length = 354 Score = 103 bits (256), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 135/292 (46%), Gaps = 3/292 (1%) Query: 5 LQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVLGQ 64 L+ L F A+ G+LGRAA LNL+QPALS+ + LE+ G LFER +G LT+ G+ Sbjct: 60 LRHLHTFVAVAQQGTLGRAAETLNLSQPALSKTLNELEQLTGARLFERGRQGAQLTLPGE 119 Query: 65 ALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNLRV 124 L HA+ + A + L G V++VGA+ + A +LP + + + Sbjct: 120 QFLTHAVRVLDAINTAGQSLHRKEGPNNDVVRVGALPTAALGILPSVIGQFHQQQKETTL 179 Query: 125 EIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQGR 184 ++ ++ GL T EID+ + + + + +V P+HPL Q+ Sbjct: 180 QVATMSNPMILAGLKTGEIDIGIGRMSDPELMTGLNYELLFLESLKLVVRPNHPLLQEN- 238 Query: 185 IALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGFIGW 244 + L + L ++P+GT P H G +P +E+ S ++ + L ++ + Sbjct: 239 VTLSRVLEWPVVVSPEGTAPRQHSDALVQSQGCKIPSGCIETLSASLSRQLTVEYDYVWF 298 Query: 245 M-SGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQGILPAPAARLLDELR 295 + SG + D R A +VAL V G A + R + +++ +R Sbjct: 299 VPSGAVKDDLRHA-TLVALPVPGHGAGEPIGILTRVDATFSSGCQLMINAIR 349 >ECs2027 [K] COG0583 Transcriptional regulator Ecs Escherichia coli O157:H7 Length = 354 Score = 103 bits (256), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 135/292 (46%), Gaps = 3/292 (1%) Query: 5 LQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVLGQ 64 L+ L F A+ G+LGRAA LNL+QPALS+ + LE+ G LFER +G LT+ G+ Sbjct: 60 LRHLHTFVAVAQQGTLGRAAETLNLSQPALSKTLNELEQLTGARLFERGRQGAQLTLPGE 119 Query: 65 ALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNLRV 124 L HA+ + A + L G V++VGA+ + A +LP + + + Sbjct: 120 QFLTHAVRVLDAINTAGQSLHRKEGPNNDVVRVGALPTAALGILPSVIGQFHQQQKETTL 179 Query: 125 EIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQGR 184 ++ ++ GL T EID+ + + + + +V P+HPL Q+ Sbjct: 180 QVATMSNPMILAGLKTGEIDIGIGRMSDPELMTGLNYELLFLESLKLVVRPNHPLLQEN- 238 Query: 185 IALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGFIGW 244 + L + L ++P+GT P H G +P +E+ S ++ + L ++ + Sbjct: 239 VTLSRVLEWPVVVSPEGTAPRQHSDALVQSQGCKIPSGCIETLSASLSRQLTVEYDYVWF 298 Query: 245 M-SGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQGILPAPAARLLDELR 295 + SG + D R A +VAL V G A + R + +++ +R Sbjct: 299 VPSGAVKDDLRHA-TLVALPVPGHGAGEPIGILTRVDATFSSGCQLMINAIR 349 >CAC3361 [K] COG0583 Transcriptional regulator Cac Clostridium acetobutylicum Length = 312 Score = 101 bits (252), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 111/223 (49%), Gaps = 4/223 (1%) Query: 4 NLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVLG 63 + +Q E I S+ RAA L ++QP+LS+ I RLE S+G LF+R + + LT G Sbjct: 2 DFRQFEYVKTIAEEKSISRAAERLYISQPSLSQYIIRLENSLGVKLFDRTSATITLTFAG 61 Query: 64 QALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNLR 123 + + A ++ Q +EL+ I L+KG + +G +LPL + ++PN+ Sbjct: 62 EKYIETARNIINLNNQLTKELNDIANLSKGRVIIGVPSQAGRYILPLVIPKFYKEYPNIE 121 Query: 124 VEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPL-RQQ 182 + + E + L + LL +ID+A+ T Q E + + + +++A HP+ Sbjct: 122 IIVEENIVSELEKMLLEGKIDIAILTLPVQHEKIT--YESIMNERIFLIAPKKHPICSVD 179 Query: 183 GRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVE 225 GRI+ +++ L KG L V + F+R G P I +E Sbjct: 180 GRISFNFIRNEKFILLKKGQRIRLIVDDIFSRIG-AKPNIILE 221 >PA2469 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 304 Score = 99.8 bits (247), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 108/217 (49%) Query: 13 AIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVLGQALLPHAMS 72 +++ G+L A + TQP LS+ +K LEE VG LFERH +G+ T G L HA Sbjct: 17 SLMETGNLSGTARAAHTTQPGLSKWLKELEEDVGAPLFERHARGLRPTPYGMTLFNHAQR 76 Query: 73 LQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNLRVEIIEGVWD 132 + E ++AR+ L+A+R + + +G + A ++P A+R L ++P +VE++EG + Sbjct: 77 VLTEMERARQNLEAMRSGSGSRVLLGTSPASAPSLVPRALRAFLGRYPGAQVELLEGTMN 136 Query: 133 RLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQGRIALEQTLG 192 L+E L ++D+ + + + +++ V+A P HPL Q + E Sbjct: 137 GLLERLEKRQLDVVVGRLDNYAPRASLRCEVLYSEAIVVMARPGHPLAQAAALDWEDVRR 196 Query: 193 QRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSV 229 W + P G+ + + G P +ES S+ Sbjct: 197 YDWIVWPPGSPIRSKLDMALTQGGRQPPAYRLESSSM 233 >STM2180 [K] COG0583 Transcriptional regulator Sty Salmonella typhimurium LT2 Length = 302 Score = 99.8 bits (247), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 2/279 (0%) Query: 3 FNLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVL 62 L L+ A+ G+L A ++N++QPALS+ + +LE+ +G LFERH+KG+ + Sbjct: 8 LKLHHLQTLVALGEQGNLTHVARMMNISQPALSKWLSQLEDEIGITLFERHSKGLRPSEG 67 Query: 63 GQALLPHAMSLQREAQQAREELDAIR-GLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPN 121 G+ LL HA L + ++++ E+ + G G +K+G +A+ + A+ +L++ P Sbjct: 68 GKLLLQHAQRLINDLERSQYEIARFKQGGLVGSLKIGC-SPVATDCVSQAILSLLNEMPT 126 Query: 122 LRVEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQ 181 L + I E V L+ LL ++D+ + GG+ + +T+ VA P HPL Sbjct: 127 LHLNIEEKVMTPLLHDLLAGQVDVVVGRVGGRALQLPLNYQVLYTEPVCFVARPHHPLAA 186 Query: 182 QGRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGF 241 + +IA RW + P GT + + +G+ +PE +ES S+ V +L+ Sbjct: 187 RAQIAWSDLAHWRWIVWPTGTPIRISIDNALVDNGVMLPENTIESASMNVSTNLLQSSDM 246 Query: 242 IGWMSGPMFDTERQAGVIVALEVAGLDAPRTLTAFRRRQ 280 I +S + G + L + ++ ++ F R+ Sbjct: 247 ISILSLRLAQRYASQGQLAILNLPKIEQKGSVGMFWRKN 285 >STM1625 [K] COG0583 Transcriptional regulator Sty Salmonella typhimurium LT2 Length = 307 Score = 98.2 bits (243), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 125/258 (48%), Gaps = 2/258 (0%) Query: 3 FNLQQLEMFNAIVSAGSLGRAAALLNLTQPALSRAIKRLEESVGGALFERHTKGMHLTVL 62 L+ L F A+ G+LGRAA LNL+QPALS+ + LE+ G LFER G LTV Sbjct: 11 IRLRHLHTFVAVAQQGTLGRAAETLNLSQPALSKTLNELEQLTGTRLFERGRLGAQLTVP 70 Query: 63 GQALLPHAMSLQREAQQAREELDAIRGLAKGVIKVGAVGSIASLVLPLAVRGVLDKWPNL 122 G+ L HA+ + A + L+ + V++VGA+ + A +LP A+ + + Sbjct: 71 GEQFLTHAVKVLDALNTAGQALNRKEDASADVVRVGALPTAALGILPAAIGRFHQQQKST 130 Query: 123 RVEIIEGVWDRLVEGLLTHEIDLALSTSGGQTEGVAAIADCCWTDLSYVVAAPDHPLRQQ 182 +++ L+ GL + EIDL + + + + +V P HPL Q+ Sbjct: 131 SLQVATMNNTMLLAGLKSGEIDLGIGRMSDPELMGGLNYELLFLESLKLVVRPGHPLLQE 190 Query: 183 GRIALEQTLGQRWALTPKGTGPYLHVQETFARHGLPMPEIAVESRSVTVLKSLVARCGFI 242 I L + + ++PKGT P + + G MP +E+ S ++ + L ++ Sbjct: 191 -TITLSRVMEWPVVVSPKGTVPRQNAEALLQSQGCKMPAGCIETLSASLSRQLTVDYDYV 249 Query: 243 GWM-SGPMFDTERQAGVI 259 ++ SG + + RQA ++ Sbjct: 250 WFVPSGAVKEDLRQATLV 267