BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0194.p (272 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value TM0954 [G] COG3959 Transketolase, N-terminal subunit Tma Thermot... 200 3e-51 AGc3490 [G] COG3959 Transketolase, N-terminal subunit Atu Agroba... 177 2e-44 FN0294 [G] COG3959 Transketolase, N-terminal subunit Fnu Fusobac... 175 1e-43 MJ0681 [G] COG3959 Transketolase, N-terminal subunit Mja Methano... 171 2e-42 TVN0668 [G] COG3959 Transketolase, N-terminal subunit Tvo Thermo... 170 3e-42 PAE1929 [G] COG3959 Transketolase, N-terminal subunit Pya Pyroba... 157 3e-38 Ta0618 [G] COG3959 Transketolase, N-terminal subunit Tac Thermop... 156 4e-38 SP2128 [G] COG3959 Transketolase, N-terminal subunit Spn Strepto... 156 6e-38 mll5765 Non COG 155 1e-37 STM2341 [G] COG3959 Transketolase, N-terminal subunit Sty Salmon... 155 1e-37 >TM0954 [G] COG3959 Transketolase, N-terminal subunit Tma Thermotoga maritima Length = 286 Score = 200 bits (508), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 110/261 (42%), Positives = 150/261 (57%), Gaps = 2/261 (0%) Query: 2 KNDFVDLRAKAHWVWCETLAIHRRAPETRLASSLSSIDIFVALYYGGVLRFNPADPRDAG 61 +++ ++L+ KA + L + +A SLSS++I V L+Y +LR P DP Sbjct: 6 RHEVLELKRKAIEIRKMILDMIYKAKSGHTGGSLSSVEILVTLFYK-ILRVKPEDPNWED 64 Query: 62 RDRCVISKGHGSICMYPILADLGYFPMEELQHVCEAGSFLGGIPDPVIPGYETVNGSLGH 121 RDR ++SKGH Y +LAD G+FP EEL+ C+ GS L G P +PG E G+LGH Sbjct: 65 RDRFILSKGHSVEAYYAVLADKGFFPKEELETYCKYGSRLTGHPTRKVPGVEVNTGALGH 124 Query: 122 GLGVATGMALGLKRSGSDRSVFVVAGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRIS 181 GL + GMAL K G D V+V+ GDGEL EG+ WEA AS + LDNL IVD NR+ Sbjct: 125 GLAIGVGMALAGKMDGKDYKVYVLMGDGELDEGSVWEAAQVASHYSLDNLIGIVDRNRLQ 184 Query: 182 MLGYTEDIVSHGELATRLSAFGWDCMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTLK 241 + G+TE+++ L+ R AFGW+ +EVDGHD S+ + GKP IIA T+K Sbjct: 185 ISGHTEEVLKLEPLSKRWEAFGWNVLEVDGHDFESLYKTFVSI-PRETGKPHLIIANTIK 243 Query: 242 GHGVPGLENAPLSHIINPKPE 262 G G+ +E H P E Sbjct: 244 GKGISFIEGRVEWHHKVPSDE 264 >AGc3490 [G] COG3959 Transketolase, N-terminal subunit Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 269 Score = 177 bits (449), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 95/217 (43%), Positives = 128/217 (58%), Gaps = 6/217 (2%) Query: 35 LSSIDIFVALYYGGVLRFNPADPRDAGRDRCVISKGHGSICMYPILADLGYFPMEELQHV 94 +S+IDI ALY+ VLR P DP++ RDR V+SKGH + +Y LA G+ P EE+ Sbjct: 33 MSAIDIMTALYFR-VLRIWPNDPKNPARDRFVLSKGHTACALYVTLAKRGFIPEEEISTF 91 Query: 95 CEAGSFLGGIPD-PVIPGYETVNGSLGHGLGVATGMALGLKRSGSDRSVFVVAGDGELHE 153 + S L G P+ +PG ET G LGHGL VA GMA K SG D +V+ GDGE+ E Sbjct: 92 LQPNSRLNGHPNCNKVPGVETNTGPLGHGLPVAVGMATAAKLSGEDYHTYVMTGDGEMQE 151 Query: 154 GANWEAIMFASQHKLDNLHLIVDDNRISMLGYTEDIVSHGELATRLSAFGWDCMEVDGHD 213 G+NWEAIM A+Q KL+NL L++D NR D L +L AFGW+ E++G+ Sbjct: 152 GSNWEAIMSAAQFKLNNLTLVIDHNRFQQGAAIADTNDVAPLRPKLEAFGWEVTEINGNA 211 Query: 214 VLSVQAALLQQKAHAAGKPKAIIARTLKGHGVPGLEN 250 + V AL H +P I+A T KGHG+ +++ Sbjct: 212 MAEVVPAL----EHRGNRPHCIVAHTNKGHGISFMQD 244 >FN0294 [G] COG3959 Transketolase, N-terminal subunit Fnu Fusobacterium nucleatum Length = 270 Score = 175 bits (443), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 103/267 (38%), Positives = 146/267 (54%), Gaps = 3/267 (1%) Query: 3 NDFVDLRAKAHWVWCETLAIHRRAPETRLASSLSSIDIFVALYYGGVLRFNPADPRDAGR 62 D L+ KA + +++ A SLS+ DI ALY+ + +P +P+ GR Sbjct: 2 KDISFLKEKAKEIRKSIVSMIAEAKSGHPGGSLSATDILTALYFSE-MNVDPTNPKMEGR 60 Query: 63 DRCVISKGHGSICMYPILADLGYFPMEELQHVCEAGSFLGGIPD-PVIPGYETVNGSLGH 121 DR V+SKGH + +Y LA+ GYF +EL + + GS L G PD + G E GSLG Sbjct: 61 DRFVLSKGHAAPAIYATLAEKGYFSKDELMTLRKFGSRLQGHPDMKKLSGIEISTGSLGQ 120 Query: 122 GLGVATGMALGLKRSGSDRSVFVVAGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRIS 181 GL VA GMAL K + +VV GDGE+ EG WEA M A+ +KLDNL +D N + Sbjct: 121 GLSVANGMALNAKIFDENYRTYVVLGDGEIQEGQIWEAAMTAAHYKLDNLCAFLDSNNLQ 180 Query: 182 MLGYTEDIVSHGELATRLSAFGWDCMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTLK 241 + G +I L + AFGW+ +++DGHD + +A L++ GKP IIA+T+K Sbjct: 181 IDGNVTEIKGVEPLDKKWEAFGWNVIKIDGHDFEQILSA-LEKARECKGKPTMIIAKTIK 239 Query: 242 GHGVPGLENAPLSHIINPKPELIDDLL 268 G GV +EN H + P E ++ L Sbjct: 240 GKGVSFMENVCGFHGVAPTVEELERAL 266 >MJ0681 [G] COG3959 Transketolase, N-terminal subunit Mja Methanococcus jannaschii Length = 274 Score = 171 bits (433), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 98/237 (41%), Positives = 137/237 (57%), Gaps = 1/237 (0%) Query: 34 SLSSIDIFVALYYGGVLRFNPADPRDAGRDRCVISKGHGSICMYPILADLGYFPMEELQH 93 SLS+ DI VALY+ ++ ++P +P RDR V+SKGH + +Y +L++LG EEL Sbjct: 36 SLSATDIIVALYFK-LMNYSPDNPYKKDRDRFVLSKGHAAPALYAVLSELGIIEEEELWK 94 Query: 94 VCEAGSFLGGIPDPVIPGYETVNGSLGHGLGVATGMALGLKRSGSDRSVFVVAGDGELHE 153 + L G P PG E GSLG G A GMALG + + V+V+ GDGE E Sbjct: 95 LRRLEGKLQGHPSMDTPGVEICTGSLGQGFSAAVGMALGCRLDKLNNYVYVLLGDGECQE 154 Query: 154 GANWEAIMFASQHKLDNLHLIVDDNRISMLGYTEDIVSHGELATRLSAFGWDCMEVDGHD 213 G WEA M A+ +KLDNL +D N++ + G TED++S G++ + AFGWD E+DGH+ Sbjct: 155 GIVWEAAMAAAHYKLDNLIAFIDRNKLQIDGCTEDVMSLGDIKAKFEAFGWDVFEIDGHN 214 Query: 214 VLSVQAALLQQKAHAAGKPKAIIARTLKGHGVPGLENAPLSHIINPKPELIDDLLEK 270 + + + K+ GKPK IIA T+KG GV +EN H P E + LE+ Sbjct: 215 FEEIINTVEKAKSMKNGKPKMIIAYTVKGKGVSFMENNVAFHGKAPNEEQLKQALEE 271 >TVN0668 [G] COG3959 Transketolase, N-terminal subunit Tvo Thermoplasma volcanium Length = 273 Score = 170 bits (431), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 93/255 (36%), Positives = 141/255 (55%), Gaps = 3/255 (1%) Query: 1 MKNDFVDLRAKAHWVWCETLAIHRRAPETRLASSLSSIDIFVALYYGGVLRFNPADPRDA 60 M+ +DL A + E + + A SLS DI LY+ + +P P+D Sbjct: 1 MEATQIDLSDIALKIRREIIRMVYNAQSGHPGGSLSVTDILTVLYFKE-MNIDPNKPKDP 59 Query: 61 GRDRCVISKGHGSICMYPILADLGYFPMEELQHVCEAGSFLGGIPDPVIPGYETVNGSLG 120 RDR ++SKGH S +Y LA G+FP+ +L + S L G +PG E GSLG Sbjct: 60 KRDRLILSKGHASPALYATLAIRGFFPVSDLSGFRKLDSHLEGHVTREVPGVEVSTGSLG 119 Query: 121 HGLGVATGMALGLKRSGSDRSVFVVAGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRI 180 GLG+ GMAL + G V+V+ GDGE+ EG WE++M ++ L+N+ I+D N I Sbjct: 120 QGLGIGVGMALAGRLDGMQYRVYVILGDGEMEEGNVWESLMAGYKYNLNNITAILDKNGI 179 Query: 181 SMLGYTEDIVSHGELATRLSAFGWDCMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTL 240 + GYT+DI+ ++ + + +FGW+ +E+DGH+ + A+ Q + + +P IIA T+ Sbjct: 180 QLDGYTKDIMPMHDIKSMVESFGWNVIEIDGHNYDQIHEAV--QASKNSDRPTFIIANTV 237 Query: 241 KGHGVPGLENAPLSH 255 KG GV +EN P H Sbjct: 238 KGKGVDFMENNPKYH 252 >PAE1929 [G] COG3959 Transketolase, N-terminal subunit Pya Pyrobaculum aerophilum Length = 267 Score = 157 bits (397), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 90/237 (37%), Positives = 139/237 (58%), Gaps = 6/237 (2%) Query: 27 PETRLASSLSSIDIFVALYYGGVLRFNPADPRDAGRDRCVISKGHGSICMYPILADLGYF 86 P L SSLS I+I ALY G ++FN A+ R+ V+SKGH +Y + A +GY Sbjct: 27 PGIHLGSSLSVIEIVAALYGTGRVKFNVANGAH-NRNYFVLSKGHAIHAVYALAAAMGYL 85 Query: 87 PMEELQHVCEAGSFLGGIPDPVIPGYETVN-GSLGHGLGVATGMALGLKRSGSDRSVFVV 145 ++EL+ GS L P+ P + N GSLG G+ +A G+ALG+K G V++V Sbjct: 86 SLDELRETGSLGSRLQNHPEVDTPFVDVPNSGSLGQGISLAVGLALGMKIKGEKGRVYLV 145 Query: 146 AGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRISMLGYTEDIVSHGELATRLSAFGWD 205 GDGEL EG +WE+ A+ + L NL IVD N + + G++E+++ G+LA R + G++ Sbjct: 146 VGDGELDEGQSWESFAVAAHYNLTNLVTIVDFNGVQLDGHSEEVLRKGDLAGRFKSLGFE 205 Query: 206 CMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTLKGHGVPGLENAPLSHIINPKPE 262 +E DGH++ + AAL +KA +P IIA+T++G G+ +E+ + P+ E Sbjct: 206 VIEADGHNIGEIIAAL--EKAERGERPAVIIAKTIRGRGIAQIEDTAKQRL--PRDE 258 >Ta0618 [G] COG3959 Transketolase, N-terminal subunit Tac Thermoplasma acidophilum Length = 273 Score = 156 bits (395), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 100/262 (38%), Positives = 146/262 (55%), Gaps = 3/262 (1%) Query: 1 MKNDFVDLRAKAHWVWCETLAIHRRAPETRLASSLSSIDIFVALYYGGVLRFNPADPRDA 60 M+ VDL A + E + + A SLS DI LY+ + +P +P D Sbjct: 1 METYQVDLSEIALRIRREIVRMVYNAQSGHPGGSLSVADILTVLYFKE-MNIDPKNPNDP 59 Query: 61 GRDRCVISKGHGSICMYPILADLGYFPMEELQHVCEAGSFLGGIPDPVIPGYETVNGSLG 120 RDR ++SKGH S +Y LA G+FP+ +L + S L G IPG E GSLG Sbjct: 60 KRDRLILSKGHASPALYATLALRGFFPVSDLAGFRKIDSHLEGHVSREIPGVEVSTGSLG 119 Query: 121 HGLGVATGMALGLKRSGSDRSVFVVAGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRI 180 GLGV GMAL + +G + V+V+ GDGE+ EG WE++M ++KL+NL I+D N I Sbjct: 120 QGLGVGVGMALASRLNGFNYHVYVILGDGEMEEGNVWESLMAGYKYKLNNLVAILDRNGI 179 Query: 181 SMLGYTEDIVSHGELATRLSAFGWDCMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTL 240 + GYT DI+ ++ + +FGW+ +E+DGH ++ A+ +K+ + +P IIA T+ Sbjct: 180 QLDGYTRDIMPLHDIHAMVESFGWNVIEIDGHSFSEIEDAI--EKSKRSERPTFIIANTV 237 Query: 241 KGHGVPGLENAPLSHIINPKPE 262 KG GV +EN P H P+ E Sbjct: 238 KGKGVDFMENNPKYHGSPPESE 259 >SP2128 [G] COG3959 Transketolase, N-terminal subunit Spn Streptococcus pneumoniae TIGR4 Length = 285 Score = 156 bits (394), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 93/262 (35%), Positives = 135/262 (51%), Gaps = 2/262 (0%) Query: 2 KNDFVDLRAKAHWVWCETLAIHRRAPETRLASSLSSIDIFVALYYGGVLRFNPADPRDAG 61 KN LR A + TL SLS +++ +A+ YG ++ P Sbjct: 5 KNREDGLRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEV-LAVLYGEIMPMTPEIFAARD 63 Query: 62 RDRCVISKGHGSICMYPILADLGYFPMEELQHVCEAGSFLGGIPD-PVIPGYETVNGSLG 120 RD ++SKGHG +Y L G+F E L + G+ L PD + PG + GSLG Sbjct: 64 RDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTKLPSHPDRNLTPGIDMTTGSLG 123 Query: 121 HGLGVATGMALGLKRSGSDRSVFVVAGDGELHEGANWEAIMFASQHKLDNLHLIVDDNRI 180 G+ VATG+A G + S + + GDGEL+EG WEAI FAS +L NL + VDDN+ Sbjct: 124 QGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCWEAIQFASHQQLSNLIVFVDDNKK 183 Query: 181 SMLGYTEDIVSHGELATRLSAFGWDCMEVDGHDVLSVQAALLQQKAHAAGKPKAIIARTL 240 + G+T+DI + G+ + SAFG++ + V G D+ + ++Q K PK I+ T+ Sbjct: 184 QLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVLDTI 243 Query: 241 KGHGVPGLENAPLSHIINPKPE 262 KG GV LE +H + P E Sbjct: 244 KGQGVQELEEMKSNHHLRPTVE 265 >mll5765 Non COG Length = 279 Score = 155 bits (392), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 95/247 (38%), Positives = 132/247 (53%), Gaps = 7/247 (2%) Query: 31 LASSLSSIDIFVALYYGGVLRFNPADPRDAGRDRCVISKGHGSICMYPILADLGYFPMEE 90 + +L D+ Y+ LR+ P D GRDR ++S GH +I +Y L + G P EE Sbjct: 33 VGQALGVADVLAVAYFH-ALRYRPDDTLWEGRDRFLLSIGHYAIALYAALIEAGVLPEEE 91 Query: 91 LQHVCEAGSFL--GGIPDPVIPGYETVNGSLGHGLGVATGMALGLKRSGSDRSVFVVAGD 148 L+ S + G+ PG E GSLGHGLG+A GM LGLKR SD V+ + D Sbjct: 92 LETYGTDDSRMPMSGMA-AYTPGMEITGGSLGHGLGIAVGMCLGLKRKQSDCFVYNLLSD 150 Query: 149 GELHEGANWEAIMFASQHKLDNLHLIVDDNRISMLGYTEDIVSHGELATRLSAFGWDCME 208 GEL EG+ WEA M A+ HKLDNL IVD N + G + ++S + + AFGW Sbjct: 151 GELGEGSTWEAAMSAAHHKLDNLIAIVDFNNLQADGPSTAMLSSEPVTDKFEAFGWHAQR 210 Query: 209 VDGHDVLSVQAALLQQKAHAAGKPKAIIARTLKGHGVPGLENAPLSHIINPKP---ELID 265 VDG+D+ +++AA + +P+ I+ T GVP LE ++H I +P L Sbjct: 211 VDGNDIEALRAAFDNARGLKDPRPRIIVCDTRMAKGVPFLEARDITHFIRVEPYEWALAL 270 Query: 266 DLLEKNR 272 + LEK R Sbjct: 271 EALEKGR 277 >STM2341 [G] COG3959 Transketolase, N-terminal subunit Sty Salmonella typhimurium LT2 Length = 276 Score = 155 bits (391), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 87/223 (39%), Positives = 130/223 (58%), Gaps = 3/223 (1%) Query: 34 SLSSIDIFVALYYGGVLRFNPADPRDAGRDRCVISKGHGSICMYPILADLGYFPMEELQH 93 S+S ++ +A+ YG V++ +PADP RD V+SKGH +Y LA GYFP EEL Sbjct: 32 SMSVVET-LAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIKGYFPREELNT 90 Query: 94 VCEAGSFLGGIPDPV-IPGYETVNGSLGHGLGVATGMALGLKRSGSDRSVFVVAGDGELH 152 + + G+ L PD + G + GSLG G+ +A GMAL K + VF + GDGEL+ Sbjct: 91 LNQNGTRLPSHPDRLKTRGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELN 150 Query: 153 EGANWEAIMFASQHKLDNLHLIVDDNRISMLGYTEDIVSHGELATRLSAFGWDCMEVDGH 212 EG WEA F + H+L+NL + +D N+ + G E+I++ +L + AFG+D + V G Sbjct: 151 EGQCWEAFQFIAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFGFDVVTVKGD 210 Query: 213 DVLSVQAALLQQKAHAAGKPKAIIARTLKGHGVPGLENAPLSH 255 D+ + A++Q A +P+ +I ++KG GVP LE SH Sbjct: 211 DIAGL-LAVVQPVPPADAQPRVVILDSIKGQGVPCLEQLTNSH 252