BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0096.p (311 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2791 [G] COG0524 Sugar kinases, ribokinase family Rso Ralston... 428 e-120 ML0873 [G] COG0524 Sugar kinases, ribokinase family Mle Mycobact... 192 7e-49 Rv2202c [G] COG0524 Sugar kinases, ribokinase family Mtu Mycobac... 183 5e-46 MT2258 [G] COG0524 Sugar kinases, ribokinase family MtC Mycobact... 183 5e-46 MJ0406 [G] COG0524 Sugar kinases, ribokinase family Mja Methanoc... 143 5e-34 MA1373 [G] COG0524 Sugar kinases, ribokinase family Mac Methanos... 124 4e-28 MTH1544 [G] COG0524 Sugar kinases, ribokinase family Mth Methano... 105 2e-22 Ta0880 [G] COG0524 Sugar kinases, ribokinase family Tac Thermopl... 100 7e-21 APE0012 [G] COG0524 Sugar kinases, ribokinase family Ape Aeropyr... 87 6e-17 AF0401 [G] COG0524 Sugar kinases, ribokinase family Afu Archaeog... 77 7e-14 >RSc2791 [G] COG0524 Sugar kinases, ribokinase family Rso Ralstonia solanacearum Length = 311 Score = 428 bits (1101), Expect = e-120, Method: Compositional matrix adjust. Identities = 194/310 (62%), Positives = 246/310 (79%) Query: 1 MSSLICGSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLL 60 M+S+ICGS+AYD IM ++G F E +L D++H +NVSFLVP+MRREFGGCAGNIAY LKLL Sbjct: 1 MASVICGSVAYDTIMTFDGHFREHILPDKIHILNVSFLVPSMRREFGGCAGNIAYTLKLL 60 Query: 61 GGDPVIMATVGLDSAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFHPGA 120 GG+P++MATVG D+APYL+ +LGIST +++I +FTAQ ITTD D+NQITAFHPGA Sbjct: 61 GGEPIVMATVGQDAAPYLDYLKKLGISTAHIKEIPGTFTAQAMITTDRDNNQITAFHPGA 120 Query: 121 MTWSHENKVADAGPVKFAIVAPDGRDGMLQHAQQAAELNIPLIFDPGQGMPMFDGEDLKN 180 M+ SH N V +A P + +V PD RDGML HA Q AE +P IFD GQ MP+FDG DL+ Sbjct: 121 MSESHVNSVKNALPARLGLVGPDSRDGMLHHATQFAEAGVPFIFDLGQAMPLFDGADLRR 180 Query: 181 FIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELGAEIFEGGKKFDIPCVP 240 F++LA+YV VNDYEA+++ +RTG S ++A+R +A IVTRGE GAEI GGK++++P VP Sbjct: 181 FVELASYVVVNDYEAQVMLSRTGYSATELAQRVEAFIVTRGEQGAEIHAGGKQYNVPAVP 240 Query: 241 ADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSRAEIEE 300 A+++ DPTGCGDAFR G+L+G+ G DWETTGRLASLMGS+KIA QGPQNH EI Sbjct: 241 AEQVVDPTGCGDAFRGGLLYGIENGLDWETTGRLASLMGSLKIACQGPQNHGLPVDEIAR 300 Query: 301 RFHAAFGYRF 310 RF +AFGYR+ Sbjct: 301 RFESAFGYRY 310 >ML0873 [G] COG0524 Sugar kinases, ribokinase family Mle Mycobacterium leprae Length = 324 Score = 192 bits (488), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 110/300 (36%), Positives = 166/300 (55%), Gaps = 5/300 (1%) Query: 1 MSSLICGSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLL 60 M+ + GS+A D++M++ GRF+E LL D LHKV++SFLV + GG AGN+AY + +L Sbjct: 1 MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIHRGGVAGNMAYAIGVL 60 Query: 61 GGDPVIMATVGLDSAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFHPGA 120 GGD ++ VG D A Y + G++ V ++ TA+ TTD D QI +F+ GA Sbjct: 61 GGDVALIGAVGDDFADYRDWLQNHGVNCDSVLISKTAHTARFVCTTDLDMAQIGSFYTGA 120 Query: 121 MTWSHENKVADA----GPVKFAIVAPDGRDGMLQHAQQAAELNIPLIFDPGQGMPMFDGE 176 M+ + K+ DA G + I+ + ML + Q+ +L + DP Q + GE Sbjct: 121 MSEARNIKLVDAIATIGTPELVIIGANDPAAMLGYTQECRKLGLAFAADPSQQLARLSGE 180 Query: 177 DLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELGAEIFE-GGKKFD 235 +++N ID ATY+ NDYE +LL ++TG S A + + + + T G G ++ E G + Sbjct: 181 EIRNLIDGATYLFTNDYEWDLLLSKTGWSEADVMAQIQLRVTTLGAKGVDLVEPDGTRVH 240 Query: 236 IPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSR 295 + VP DPTG GDAFRAG L G + G E + +L SL+ + + S G Q R Sbjct: 241 VSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLSLERSAQLGSLVAVLVLESTGTQQWGWDR 300 >Rv2202c [G] COG0524 Sugar kinases, ribokinase family Mtu Mycobacterium tuberculosis H37Rv Length = 324 Score = 183 bits (464), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 104/312 (33%), Positives = 166/312 (53%), Gaps = 5/312 (1%) Query: 1 MSSLICGSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLL 60 M+ + GS+A D++M++ GRF+E LL + LHKV++SFLV + GG AGN+A+ + +L Sbjct: 1 MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVL 60 Query: 61 GGDPVIMATVGLDSAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFHPGA 120 GG+ ++ G D A Y + G++ V +++ TA+ TTD D QI +F+PGA Sbjct: 61 GGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGA 120 Query: 121 MTWSHENKVADA----GPVKFAIVAPDGRDGMLQHAQQAAELNIPLIFDPGQGMPMFDGE 176 M+ + K+AD G + I+ + + M H ++ +L + DP Q + GE Sbjct: 121 MSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGE 180 Query: 177 DLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELGAEIFE-GGKKFD 235 +++ ++ A Y+ NDYE +LL ++TG S A + + + T G G ++ E G Sbjct: 181 EIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIH 240 Query: 236 IPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSR 295 + VP DPTG GDAFRAG L G + G E + +L SL+ + + S G Q Sbjct: 241 VGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDY 300 Query: 296 AEIEERFHAAFG 307 R A+G Sbjct: 301 EAAASRLAGAYG 312 >MT2258 [G] COG0524 Sugar kinases, ribokinase family MtC Mycobacterium tuberculosis CDC1551 Length = 324 Score = 183 bits (464), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 104/312 (33%), Positives = 166/312 (53%), Gaps = 5/312 (1%) Query: 1 MSSLICGSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLL 60 M+ + GS+A D++M++ GRF+E LL + LHKV++SFLV + GG AGN+A+ + +L Sbjct: 1 MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVL 60 Query: 61 GGDPVIMATVGLDSAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFHPGA 120 GG+ ++ G D A Y + G++ V +++ TA+ TTD D QI +F+PGA Sbjct: 61 GGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGA 120 Query: 121 MTWSHENKVADA----GPVKFAIVAPDGRDGMLQHAQQAAELNIPLIFDPGQGMPMFDGE 176 M+ + K+AD G + I+ + + M H ++ +L + DP Q + GE Sbjct: 121 MSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGE 180 Query: 177 DLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELGAEIFE-GGKKFD 235 +++ ++ A Y+ NDYE +LL ++TG S A + + + T G G ++ E G Sbjct: 181 EIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIH 240 Query: 236 IPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSR 295 + VP DPTG GDAFRAG L G + G E + +L SL+ + + S G Q Sbjct: 241 VGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDY 300 Query: 296 AEIEERFHAAFG 307 R A+G Sbjct: 301 EAAASRLAGAYG 312 >MJ0406 [G] COG0524 Sugar kinases, ribokinase family Mja Methanococcus jannaschii Length = 302 Score = 143 bits (361), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 94/309 (30%), Positives = 149/309 (48%), Gaps = 23/309 (7%) Query: 1 MSSLIC-GSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKL 59 M + C G A D I E +F E N S +P+ R+ +GG A N A +K Sbjct: 5 MEKITCVGHTALDYIFNVE-KFPEP---------NTSIQIPSARKYYGGAAANTAVGIKK 54 Query: 60 LGGDPVIMATVGLD--SAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFH 117 LG + +++ VG D ++ Y L I+ + + T + +I TD D+NQIT F Sbjct: 55 LGVNSELLSCVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIFTDKDNNQITFF- 113 Query: 118 PGAMTWSHENKVADAGPVKFAI----VAPDGRDGMLQHAQQAAELNIPLIFDPGQGMPMF 173 W + P F +A + L+ A++A N+ + FDPGQ +P + Sbjct: 114 ----LWGAAKHYKELNPPNFNTEIVHIATGDPEFNLKCAKKAYGNNL-VSFDPGQDLPQY 168 Query: 174 DGEDLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELGAEIFEGGKK 233 E L I+ ++ +N +E E + + ER ALIVT+G G+ I+ KK Sbjct: 169 SKEMLLEIIEHTNFLFMNKHEFERASNLLNFEIDDYLERVDALIVTKGSKGSVIYTKDKK 228 Query: 234 FDIPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAP 293 +IPC+ A ++ DPTG GD++RAG L +GYD E G + + S + ++G Q + P Sbjct: 229 IEIPCIKAGKVIDPTGAGDSYRAGFLSAYVKGYDLEKCGLIGAATASFVVEAKGCQTNLP 288 Query: 294 SRAEIEERF 302 + ++ ER Sbjct: 289 TWDKVVERL 297 >MA1373 [G] COG0524 Sugar kinases, ribokinase family Mac Methanosarcina acetivorans str.C2A Length = 299 Score = 124 bits (310), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 81/263 (30%), Positives = 135/263 (51%), Gaps = 10/263 (3%) Query: 47 GGCAGNIAYNLKLLGGDPVIMATVGLD--SAPYLERFAELGISTRCVRQIDSSFTAQCFI 104 GG A NIA + LGG +M+ VG+D S+ Y + + + + I++ ++ FI Sbjct: 39 GGGAANIAVAIAKLGGKSQLMSPVGMDFSSSGYEQLLKDAHVDLSRLYSIEALKLSKAFI 98 Query: 105 TTDADSNQITAFHPGAMTWSHENKVADAGPVKFAIVAPDGRDGMLQHAQQAAELNIPLIF 164 TD + NQ T F+ GA S + K + PV FA +A + AQ A ++ F Sbjct: 99 FTDREDNQTTYFYWGA---SSKFKELEPEPVDFAHLATADCIYNAKIAQIAGFVS----F 151 Query: 165 DPGQGMPMFDGEDLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIVTRGELG 224 DPGQ + + E L+ + + N +E + ++ TG S +++ + +++T G Sbjct: 152 DPGQDLVTYSQEKLETILAHTDILFANRHEIKRVSEMTGKSFSELRAMIEVIVITYDAEG 211 Query: 225 AEIFEGGKKFDIPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIA 284 + I+ G +++ IP V + DPTG GDA+RAG L T Y T G++ S + S + Sbjct: 212 SRIYTGNEEWKIPVVSV-KAVDPTGAGDAYRAGFLLAYTREYSLPTCGKIGSTVASFAVQ 270 Query: 285 SQGPQNHAPSRAEIEERFHAAFG 307 S+G Q P+ E++ R+ A+FG Sbjct: 271 SRGCQTSLPTWEEMKSRYEASFG 293 >MTH1544 [G] COG0524 Sugar kinases, ribokinase family Mth Methanothermobacter thermautotrophicus Length = 309 Score = 105 bits (261), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 85/310 (27%), Positives = 140/310 (45%), Gaps = 17/310 (5%) Query: 4 LICGSLAYDNIMQYEGRFAEALLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLLGGD 63 L G A+D I+ D+ + N S + MR GG A N+A LG Sbjct: 8 LAVGHTAFDYIIHL----------DEFPEPNTSTAIKRMRNLHGGAAANVALVGSRLGLR 57 Query: 64 PVIMATVGLD--SAPYLERFAELGISTRCVRQIDSSFTAQCFITTDADSNQITAFHPGAM 121 +++ VG D + Y E GI + + T F+ TD+D NQI+ F+ GA Sbjct: 58 TSLVSAVGGDFEGSEYRELLESSGIDIESMILVADESTPTAFVMTDSDHNQISYFYWGAA 117 Query: 122 TWSHENKV-ADAGPVKFAIVAPDGRDGM-LQHAQQAAELNIPLIFDPGQGMPMFDGEDLK 179 + + + ADA A+ G + + A L + FDPGQ + M+ L+ Sbjct: 118 RYFKDAETPADAIKSARAVHLATGDPSFNCRCGEFARSLGKIISFDPGQDLHMYSRSQLE 177 Query: 180 NFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALIV-TRGELGAEIFEGGKKFDIPC 238 + + + N +E + + ++ + + + E ++V T G+ G+ I+ I Sbjct: 178 RAVGVCDILFGNHHEIDRICSKLSVDIHGLREMGPGVVVKTYGKEGSIIYSD-DVIKIDA 236 Query: 239 VPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSRAEI 298 +P + + DPTG GD++RAG + G D +T GR AS + S + +G Q + P E Sbjct: 237 IPREAV-DPTGAGDSYRAGFMRAYLRGADLKTCGRFASAVASFIVEDEGTQTNIPDTGEA 295 Query: 299 EERFHAAFGY 308 +RF A +GY Sbjct: 296 VKRFTAQWGY 305 >Ta0880 [G] COG0524 Sugar kinases, ribokinase family Tac Thermoplasma acidophilum Length = 287 Score = 99.8 bits (247), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 106/226 (46%), Gaps = 19/226 (8%) Query: 39 VPTMRREFGGCAGNIAYNLKLLGGDPVIMATVGLDSA-PYLERFAELGISTRCVRQIDSS 97 V +R FGG AGN A + + + VG+ + YL +GI+T V + + Sbjct: 29 VKDLRPRFGGTAGNFAIVAQKFRIPFDLYSAVGMKTHREYLAMIESMGINTGHVEKFEDE 88 Query: 98 FTAQCFITTDADSNQITAFHPGAM-TWSHENKVADAGPVKFAIVAPDGRDGMLQHAQQAA 156 C+I TD Q++ H GAM W + ++AD P+ D A Sbjct: 89 SGPICYIATDG-KKQVSFMHQGAMEKW--KPQLADEYEYVHFSTGPNYLD-------MAK 138 Query: 157 ELNIPLIFDPGQGMPMFDGEDLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKAL 216 + +IFDP Q + + ++LK F +++ ND+E + TGLS ++ Sbjct: 139 SIRSKIIFDPSQEIHKYSKDELKKFHEISYMSIFNDHEYRVFREMTGLSSPKV-----TT 193 Query: 217 IVTRGELGAEIFEGGKKFDIPCVPADRIADPTGCGDAFRAGMLFGL 262 IVT GE G+ +F GKK+D P +P+ D G GD+FRAG+ L Sbjct: 194 IVTNGERGSSLFMDGKKYDFPAIPSS--GDTVGAGDSFRAGLYLAL 237 >APE0012 [G] COG0524 Sugar kinases, ribokinase family Ape Aeropyrum pernix Length = 310 Score = 86.7 bits (213), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 12/286 (4%) Query: 25 LLADQLHKVNVSFLVPTMRREFGGCAGNIAYNLKLLGGDPVIMATVGLDS--APYLERFA 82 L +++ V+ ++ R GG A N+A L+ LG I+ +GLD ++ Sbjct: 20 LYVERIPGVDEEAVIKDETRSVGGSAANVAVVLRRLGVQSGIIGKIGLDDFGRIAVDNLM 79 Query: 83 ELGISTRCVRQIDSSFTAQCFITTDAD-SNQITAFHPGAMTWSHENKVADA-GPVKFAIV 140 G+ +R T + D + S I +F A ADA G K V Sbjct: 80 REGVDISGLRVSLRDRTGFSVVVRDKEGSITIYSFKGAAEKLEPGEIDADAIGRSKHVHV 139 Query: 141 APDGRDGMLQHAQQAAELNIPLIFDPGQGMPMFDGEDLKNFIDLATYVAVNDYEAELLTA 200 A D L+ + A + +I + +DPG+ + E L N I + VN EA+ LT Sbjct: 140 ASLRPDTTLKTVEIAKKRSITVSWDPGRVLSKMGAERLANIISKVDIIFVNRNEAKNLTG 199 Query: 201 RTGLSLAQIAERTKAL-----IVTRGELGAEIFEGGKKFDIPCVPADRIADPTGCGDAFR 255 Q A K L ++ G G+ I + +P + +R+ D TG GD++ Sbjct: 200 YH--DYRQAARHLKKLGPKIVVIKLGASGSYILYSDGEVFVPAIKPERVVDTTGAGDSYA 257 Query: 256 AGMLFGLTEGYDWETTGRLASLMGSIKIASQGPQNHAPSRAEIEER 301 AG + GL GY E A+++ SIK++ G N APS E+ E+ Sbjct: 258 AGFIAGLLRGYTIEKASLYATIVASIKVSRLG-SNAAPSHEEVVEK 302 >AF0401 [G] COG0524 Sugar kinases, ribokinase family Afu Archaeoglobus fulgidus Length = 284 Score = 76.6 bits (187), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 67/263 (25%), Positives = 113/263 (42%), Gaps = 12/263 (4%) Query: 38 LVPTMRREFGGCAGNIAYNLKLLGGDPVIMATVGLDSAPYLERFAELGISTRCVRQIDSS 97 ++ + R+ GG N+A+NL LG + + T+G D F E ++ + +I Sbjct: 27 IILSTRKSPGGAGANVAHNLASLGVESTLFTTLGRDEDGIY--FVENTLA-KVKAEITDE 83 Query: 98 FTAQCFITTDADSNQITAFHPGAMTWSHENKVADAGPVKFAIVAPDGRDGMLQHAQQAAE 157 T + + D + + P A D G + P +Q ++A Sbjct: 84 KTGKVHVFVDGEGERTFFVEPNAAGKPFVE--VDGGDYLYLDPFPSEHSFEVQR-KEAER 140 Query: 158 LNIPLIFDPGQGMPMFDGEDLKNFIDLATYVAVNDYEAELLTARTGLSLAQIAERTKALI 217 + +I +PG E LK + + ++ E LL G+ A + LI Sbjct: 141 FDGFVILNPGFPYSSLGFERLKQILQHVDMLIMSADEFSLL----GVETADVLRFVDYLI 196 Query: 218 VTRGELGAEIFEGGKKFDIPCVPADRIADPTGCGDAFRAGMLFGLTEGYDWETTGRLASL 277 VT+G+LG+ + F P PA ++AD TG GDAF AG ++G + Y E L + Sbjct: 197 VTQGKLGSACYTKKGSFQSPAFPA-KVADTTGAGDAFAAGFIYGFIKNYPLEVCLTLGNF 255 Query: 278 MGSIKIASQGPQNHAPSRAEIEE 300 G+ + G +N PS++ I+E Sbjct: 256 CGAYNVERVGARNF-PSKSTIDE 277