BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0047.p (269 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0381 [H] COG2022 Uncharacterized enzyme of thiazole biosynthes... 375 e-104 XF0783 [H] COG2022 Uncharacterized enzyme of thiazole biosynthes... 354 1e-97 CC1880 Non COG 325 9e-89 aq_2178 [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 292 6e-79 BS_yjbT [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 259 6e-69 all3519_2 [H] COG2022 Uncharacterized enzyme of thiazole biosynt... 244 2e-64 BH1433 [H] COG2022 Uncharacterized enzyme of thiazole biosynthes... 236 5e-62 Cgl1993 [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 235 6e-62 slr0633_2 [H] COG2022 Uncharacterized enzyme of thiazole biosynt... 235 7e-62 DRA0172 [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 225 1e-58 >PA0381 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Pae Pseudomonas aeruginosa Length = 265 Score = 375 bits (963), Expect = e-104, Method: Compositional matrix adjust. Identities = 184/257 (71%), Positives = 215/257 (83%) Query: 12 DKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLD 71 D IAG+TY SRLLVG+GKYKDLDETR A ASGAEI+TVA+RR NIGQ+P+ P+LLD Sbjct: 8 DTPFVIAGRTYGSRLLVGTGKYKDLDETRRAIEASGAEIVTVAVRRTNIGQNPDEPNLLD 67 Query: 72 AVPPSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLFPNMPETLKA 131 +PP +TILPNTAGCY+A +AV T +LARELL GH LVKLEVL D+KTLFPN+ ETLKA Sbjct: 68 VIPPDRYTILPNTAGCYDAVEAVRTCRLARELLDGHNLVKLEVLADQKTLFPNVVETLKA 127 Query: 132 AETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLIIEQAR 191 AE LVKDGFDVMVY SDDPI AR L ++G AVMPLA LIGSG+GI NP+NL +I+E+A+ Sbjct: 128 AEQLVKDGFDVMVYTSDDPIIARQLAEIGCIAVMPLAGLIGSGLGICNPYNLRIILEEAK 187 Query: 192 VPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREAFLSGR 251 VPVLVDAGVGTASDAAIAMELGC+ VLMNTAIA A+DP+ MA AMK A+ AGR A+L+GR Sbjct: 188 VPVLVDAGVGTASDAAIAMELGCEAVLMNTAIAHAKDPVMMAEAMKHAIVAGRLAYLAGR 247 Query: 252 IPRKFAASPSSPMAGRV 268 +PRK AS SSP+ G + Sbjct: 248 MPRKLYASASSPLDGLI 264 >XF0783 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Xfa Xylella fastidiosa 9a5c Length = 275 Score = 354 bits (909), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 176/254 (69%), Positives = 211/254 (83%) Query: 15 LTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLDAVP 74 L IAG Y SRLL G+GK+KDLDETR AT A+G++I+TVAIRRVNIGQDP+ P+LL+ + Sbjct: 21 LVIAGIVYSSRLLTGTGKFKDLDETRLATEAAGSQIVTVAIRRVNIGQDPHQPNLLNVLS 80 Query: 75 PSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLFPNMPETLKAAET 134 P +TILPNTAGCY A DAV T +LARELL GH+L KLEVLGD+KTL+P++ +TLKAAE Sbjct: 81 PDRYTILPNTAGCYTAEDAVRTCRLARELLDGHRLTKLEVLGDKKTLYPDVVQTLKAAEQ 140 Query: 135 LVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLIIEQARVPV 194 LV + F VMVY SDDPI A+ LE++G AVMPLA+ IGSG+G+ N +NL IIE A+VP+ Sbjct: 141 LVAEDFQVMVYTSDDPILAKRLEEIGCVAVMPLAAPIGSGLGVQNRYNLLEIIENAQVPI 200 Query: 195 LVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREAFLSGRIPR 254 +VDAGVGTASDAAIAMELGCD VLMNTAIAGARDP+ MA AM+ AV+AGREAFL+GRIPR Sbjct: 201 IVDAGVGTASDAAIAMELGCDAVLMNTAIAGARDPVLMASAMRKAVEAGREAFLAGRIPR 260 Query: 255 KFAASPSSPMAGRV 268 K A+ SSP+ G V Sbjct: 261 KRYAAASSPVEGLV 274 >CC1880 Non COG Length = 269 Score = 325 bits (832), Expect = 9e-89, Method: Compositional matrix adjust. Identities = 169/264 (64%), Positives = 207/264 (78%), Gaps = 2/264 (0%) Query: 5 DAPLVNEDKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDP 64 D+ + D+ T+AG+T+RSRL+VG+GKYKD AA A+GAEI+TVA+RRVN+ DP Sbjct: 8 DSVTADSDETWTVAGRTFRSRLIVGTGKYKDYATNAAAARAAGAEIVTVAVRRVNL-TDP 66 Query: 65 NAPSLLDAVPPSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLFPN 124 + P L+D V P+EFT LPNTAGC+ DAV TL+LARE GG LVKLEVL D KTLFP+ Sbjct: 67 SQPLLVDYVKPTEFTYLPNTAGCFTGEDAVRTLRLAREA-GGWDLVKLEVLSDPKTLFPD 125 Query: 125 MPETLKAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLS 184 M ETL++ + LV DGF VMVYCSDDP+ AR LE+ G A+MPL + IGSG+GI N NL Sbjct: 126 MEETLRSLKLLVADGFQVMVYCSDDPVYARKLEEAGAVAIMPLGAPIGSGLGIQNRVNLR 185 Query: 185 LIIEQARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGR 244 +IIE A+VPVLVDAGVGTASDAAI MELGCD +LMNTAIA A+DPIRMA+AMK AV AGR Sbjct: 186 IIIENAKVPVLVDAGVGTASDAAIGMELGCDAILMNTAIAEAKDPIRMAKAMKHAVIAGR 245 Query: 245 EAFLSGRIPRKFAASPSSPMAGRV 268 EA+L+GR+ ++ A PSSP+AG + Sbjct: 246 EAYLAGRMQKRLYADPSSPLAGLI 269 >aq_2178 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Aae Aquifex aeolicus Length = 267 Score = 292 bits (747), Expect = 6e-79, Method: Compositional matrix adjust. Identities = 149/264 (56%), Positives = 193/264 (73%), Gaps = 2/264 (0%) Query: 3 MNDAPLVNEDKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQ 62 M D + +D L IAG+ ++SRL++GSGK+KD +T+ ASGAEIITVA+RRVNI Sbjct: 1 MQDWEKLLQDDYLEIAGRKFKSRLIIGSGKFKDFQQTKEVLEASGAEIITVAVRRVNI-T 59 Query: 63 DPNAPSLLDAVPPSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLF 122 DP +LLD + P ++ ILPNTAGCY A +A+ T +ARE G + VKLEV+GD+KTL Sbjct: 60 DPTKENLLDYIDPKKYLILPNTAGCYTAEEAIKTAMMAREATGIN-WVKLEVIGDQKTLL 118 Query: 123 PNMPETLKAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWN 182 P+M ET KAA+ LVK+GF V+ Y DDP+ A+ ED+G AAVMPLA+ IGSG+G+ NP+N Sbjct: 119 PDMEETYKAAKVLVKEGFVVLPYIFDDPVFAKKFEDIGCAAVMPLAAPIGSGLGLQNPYN 178 Query: 183 LSLIIEQARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQA 242 L I E VPV+VDAG+G+A+D MELG DGVL NTA+A A+DPI+MA AMK A A Sbjct: 179 LIFIKEAVSVPVIVDAGIGSATDIPPVMELGVDGVLTNTALAEAKDPIKMAVAMKYATIA 238 Query: 243 GREAFLSGRIPRKFAASPSSPMAG 266 GR A+L+GR+P++ A PSSP G Sbjct: 239 GRLAYLAGRMPKRTYAVPSSPTKG 262 >BS_yjbT [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Bsu Bacillus subtilis Length = 256 Score = 259 bits (661), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 136/252 (53%), Positives = 187/252 (74%), Gaps = 2/252 (0%) Query: 15 LTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLDAVP 74 LTI GK+++SRLL+G+GKY D + A S ++I+T A+RR+NI + + P+ L+ + Sbjct: 4 LTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAVRRMNIFE-ASQPNFLEQLD 62 Query: 75 PSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLFPNMPETLKAAET 134 S++T+LPNTAG A +AV +LA+ G ++K+EV+G ++L P+ ETLKA+E Sbjct: 63 LSKYTLLPNTAGASTAEEAVRIARLAKAS-GLCDMIKVEVIGCSRSLLPDPVETLKASEQ 121 Query: 135 LVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLIIEQARVPV 194 L+++GF V+ Y SDD + AR LE+LGV A+MP AS IGSG GILNP NLS IIEQA+VPV Sbjct: 122 LLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGSGQGILNPLNLSFIIEQAKVPV 181 Query: 195 LVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREAFLSGRIPR 254 +VDAG+G+ DAA AMELG DGVL+NTA++GA DP++MARAMKLAV+AGR ++ +GRIP Sbjct: 182 IVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVKMARAMKLAVEAGRLSYEAGRIPL 241 Query: 255 KFAASPSSPMAG 266 K + SSP G Sbjct: 242 KQYGTASSPGEG 253 >all3519_2 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Nos Nostoc sp. PCC 7120 Length = 262 Score = 244 bits (622), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 133/263 (50%), Positives = 183/263 (69%), Gaps = 6/263 (2%) Query: 12 DKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLD 71 D L IAGK++ SRL+ G+GKY+ ++E + + VASG EI+TVA+RRV + P L + Sbjct: 1 DSPLIIAGKSFHSRLMTGTGKYRSIEEMQQSVVASGCEIVTVAVRRVQT-KTPGHEGLAE 59 Query: 72 AVPPSEFTILPNTAGCYNAADAVYTLQLARE---LLGG--HKLVKLEVLGDEKTLFPNMP 126 A+ S+ +LPNTAGC A +A+ +L RE LLG + VKLEV+ D K L P+ Sbjct: 60 ALDWSKIWMLPNTAGCQTAEEAIRVARLGREMAKLLGQEDNNFVKLEVIPDPKYLLPDPI 119 Query: 127 ETLKAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLI 186 TL+AAE LVK+GF V+ Y + DP+ A+ LED+G A VMPLAS IGSG G+ N+ +I Sbjct: 120 GTLQAAEQLVKEGFAVLPYINADPMLAKHLEDVGCATVMPLASPIGSGQGLKTTANIQII 179 Query: 187 IEQARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREA 246 IE A++PV+VDAG+G S+A+ AMELG D +L+N+AIA A++P MA+AM LA AGR A Sbjct: 180 IENAKIPVVVDAGIGAPSEASQAMELGADALLINSAIALAQNPAAMAQAMNLATVAGRLA 239 Query: 247 FLSGRIPRKFAASPSSPMAGRVA 269 +L+GR+P K AS SSP+ G ++ Sbjct: 240 YLAGRMPMKTYASASSPVTGTIS 262 >BH1433 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Bha Bacillus halodurans Length = 261 Score = 236 bits (601), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 127/262 (48%), Positives = 175/262 (66%), Gaps = 9/262 (3%) Query: 1 MNMNDAPLVNEDKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNI 60 M M D PL +I GKT SR +G+G+Y + S AE++T AIRRVN+ Sbjct: 1 MMMKDLPL-------SIGGKTLTSRFFLGTGRYPNPFVQNEVIRVSEAEVLTFAIRRVNL 53 Query: 61 GQDPNAPSLLDAVPPSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKT 120 Q P ++L + FT LPNT+G NA +A+ +LAR G +K+E+ +E+T Sbjct: 54 -QAPGEDAILQHLEGKTFTYLPNTSGAKNAEEAIRIARLARAS-GLSDWIKVEISVNERT 111 Query: 121 LFPNMPETLKAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNP 180 L P+ ETL+A ETL +GF V+ Y SDDP+ + LE+ G AAVMP + IG+G+GILNP Sbjct: 112 LLPDPVETLRATETLANEGFTVLPYTSDDPVLCKRLEEAGAAAVMPGGAPIGTGLGILNP 171 Query: 181 WNLSLIIEQARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAV 240 +NL LI+E+A VP++VDAG+G+A D AMELG DGVLMNT +A A+DP++MA AMK A+ Sbjct: 172 YNLGLIVEEANVPIIVDAGLGSAQDVVQAMELGADGVLMNTPVAKAKDPVKMALAMKHAI 231 Query: 241 QAGREAFLSGRIPRKFAASPSS 262 +AGR ++L+GRIP+K A+ SS Sbjct: 232 EAGRLSYLAGRIPKKRYATASS 253 >Cgl1993 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Cgl Corynebacterium glutamicum Length = 260 Score = 235 bits (600), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 132/252 (52%), Positives = 166/252 (65%), Gaps = 2/252 (0%) Query: 15 LTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLDAVP 74 L IA KT+ S L++G+G + VASG ++ TVA+RR + + S+ + Sbjct: 2 LHIADKTFDSHLIMGTGGATSQALLEESLVASGTQLTTVAMRR-HQATTSSGESIFAMLR 60 Query: 75 PSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKTLFPNMPETLKAAET 134 E +LPNTAGC A DAV T QLARE L VK+EV+ DE TL P+ E L A E Sbjct: 61 RLEIALLPNTAGCRTARDAVLTAQLAREALDT-NWVKVEVIADEHTLLPDTVELLDACEL 119 Query: 135 LVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLIIEQARVPV 194 LV DGF V+ Y SDDPI A LED GVAAVMPL S IG+G+GILNP N+ LI +A VPV Sbjct: 120 LVHDGFTVLAYTSDDPITASRLEDCGVAAVMPLGSPIGTGLGILNPHNIELICSRASVPV 179 Query: 195 LVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREAFLSGRIPR 254 ++DAGVGTASDA +AMELGCDGVL+ +AI A++P+ MA +M AV+AGR A +GRIP+ Sbjct: 180 ILDAGVGTASDATLAMELGCDGVLLASAINRAQNPVAMAESMFHAVEAGRLAAQAGRIPQ 239 Query: 255 KFAASPSSPMAG 266 + A SS G Sbjct: 240 RQHAVASSSFEG 251 >slr0633_2 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Syn Synechocystis Length = 326 Score = 235 bits (600), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 130/259 (50%), Positives = 176/259 (67%), Gaps = 6/259 (2%) Query: 15 LTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNIGQDPNAPSLLDAVP 74 L IAG+ + SRL+ G+GKY L + + +SG +I+TVA+RRV P L +A+ Sbjct: 68 LEIAGRKFHSRLMTGTGKYPSLTTMQESVASSGCQIVTVAVRRVQT-NAPGHEGLAEAID 126 Query: 75 PSEFTILPNTAGCYNAADAVYTLQLARE---LLGG--HKLVKLEVLGDEKTLFPNMPETL 129 S +LPNTAGC A +A+ +L RE LLG + +KLEV+ D + L P+ TL Sbjct: 127 WSTIWMLPNTAGCQTAEEAIRVARLGREMAKLLGQEDNNFIKLEVIPDTQYLLPDPIGTL 186 Query: 130 KAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNPWNLSLIIEQ 189 +AAE LVK+GF V+ Y + DP+ A+ LE++G A VMPL S IGSG GI N N+ +IIE Sbjct: 187 EAAEQLVKEGFAVLPYINADPLLAKRLEEVGCATVMPLGSPIGSGQGIRNAANIGIIIEN 246 Query: 190 ARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAVQAGREAFLS 249 A+VPV+VDAG+GT S+AA AME+G D VL+N+AIA A +P+ MA+AM +A QAGR A+LS Sbjct: 247 AKVPVVVDAGIGTPSEAAQAMEMGADAVLINSAIAMAANPVAMAQAMGMATQAGRLAYLS 306 Query: 250 GRIPRKFAASPSSPMAGRV 268 GR+P K A+ SSP+ G V Sbjct: 307 GRMPIKAKANASSPLTGLV 325 >DRA0172 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Dra Deinococcus radiodurans Length = 288 Score = 225 bits (573), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 137/268 (51%), Positives = 177/268 (66%), Gaps = 10/268 (3%) Query: 1 MNMNDAPLVNEDKGLTIAGKTYRSRLLVGSGKYKDLDETRAATVASGAEIITVAIRRVNI 60 MN ND LTI G+++ SRLL+G+GKY+D + A ASG +I+TVAIRRV + Sbjct: 22 MNTNDL--------LTIGGQSFSSRLLLGTGKYRDFAVMQDALGASGTQIVTVAIRRVEL 73 Query: 61 GQDPNAPSLLDAVPPSEFTILPNTAGCYNAADAVYTLQLARELLGGHKLVKLEVLGDEKT 120 + P LLDA+ F +LPNTAGC A +AV +LAR G L KLEV+ D K Sbjct: 74 -KAPGHDGLLDALDLDRFQLLPNTAGCRTAEEAVRVAKLARAATGVSWL-KLEVIPDPKY 131 Query: 121 LFPNMPETLKAAETLVKDGFDVMVYCSDDPIQARMLEDLGVAAVMPLASLIGSGMGILNP 180 L P+ TL+AAE LV +GF V+ Y D + AR LE +G A VMPLAS IG+G G+ P Sbjct: 132 LLPDPIGTLRAAEILVGEGFTVLPYVQPDGVLARALEAVGCATVMPLASPIGTGKGLRTP 191 Query: 181 WNLSLIIEQARVPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPIRMARAMKLAV 240 + +I+ A VP++VDAG+G SDAA A+ELG D VL+NTAIA ARDP+ MARA L V Sbjct: 192 ELIRTVIDGAGVPIVVDAGLGVPSDAAQALELGADAVLVNTAIAEARDPVAMARAFALGV 251 Query: 241 QAGREAFLSGRIPRKFAASPSSPMAGRV 268 +AGR +L+GR+ ++ +ASPSSP AG V Sbjct: 252 EAGRLGYLAGRMQQRDSASPSSPAAGVV 279