BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0007.p (3886 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 973 0.0 PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 957 0.0 PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 920 0.0 PA2402_4 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 913 0.0 PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 848 0.0 BS_ppsB_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 839 0.0 PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 831 0.0 PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 827 0.0 all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 825 0.0 all2648_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 819 0.0 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 973 bits (2515), Expect = 0.0, Method: Compositional matrix adjust. Identities = 614/1467 (41%), Positives = 834/1467 (56%), Gaps = 62/1467 (4%) Query: 1 VQLAWLDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHH 60 +++A+ D LP ++E RL+EE Q + FDL + L VRLI LG + HVL++ +HH Sbjct: 124 LEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRLIRLGEERHVLLLTLHH 183 Query: 61 IVSDAWSNPLVIRDLAEAYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYW 120 IVSD WS ++I + + Y + LPALP+QYADYA WQR ++ +L YW Sbjct: 184 IVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQRSWLEAGEQERQLEYW 243 Query: 121 DDYLGPVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAA 180 LG + L+LPTD PRPA S+RG+ + F+++ ALA+ ++ R Q T F+ L+ Sbjct: 244 RGKLGERHPVLELPTDHPRPAVPSYRGSRYEFSIEPALAEALRGTARRQGLTLFMLLLGG 303 Query: 181 WQVLLSRYSGQADFFFF--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRG 238 + +LL RYSGQ D A RN AE++ L+G FV TQ+ R+ +V L+ ++ Sbjct: 304 FNILLQRYSGQTDLRVGVPIANRNRAEVEGLIGLFVNTQVLRSVFDGRTSVATLLAGLKD 363 Query: 239 DMLAALEHGDLPFEALLEHRKVERDPGRNPLFQVMFGLQ-MVGEGASALAFDDIVTAPLP 297 +L A H DLPFE L+E KVER +PLFQVM+ Q +V + + + + L Sbjct: 364 TVLGAQAHQDLPFERLVEAFKVERSLSHSPLFQVMYNHQPLVADIEALDSVAGLSFGQLD 423 Query: 298 LAQDSAKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVA 357 + +FDLSLD G ++ L YA+DLF+A T+ MA H+QNLLRG P+ V Sbjct: 424 WKSRTTQFDLSLDTYEKGGRLYAALTYATDLFEARTVERMARHWQNLLRGMLENPQASVD 483 Query: 358 QLALLDQDEQARLRSWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYA 417 L +LD +E+ +L + E P G + L E Q P A A+ G +++ YA Sbjct: 484 SLPMLDAEERGQLLEGWNATAAE-YPLQRG--VHRLFEEQVERTPTAPALAFGEERLDYA 540 Query: 418 QLNRAANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRL 477 +LNR ANRLAH L+++GVG + +G+A RS+EM+V L+AILKAG AYVP+DP+YP +R Sbjct: 541 ELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQ 600 Query: 478 AYMVQDAGVTLALTAGEGVSALTAQGLRTLEI--APALADDAAPAHNPGVVLHPDNLAYI 535 AYM++D+GV L L+ + AQG++ +++ A A ++ A +NPGV L+ +NLAY+ Sbjct: 601 AYMLEDSGVQLLLSQSH-LKLPLAQGVQRIDLDQADAWLENHA-ENNPGVELNGENLAYV 658 Query: 536 IYTSGSTGRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCY 595 IYTSGSTG+PKGA H+ + L + G D ++FD SVWE F L Sbjct: 659 IYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMS 718 Query: 596 GGRLVVVPFAVSRSPEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVI 655 G RLVV R P + L+ + V L+ PS + LQ + + +L+ ++ Sbjct: 719 GARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDV----ASCTSLKRIV 774 Query: 656 FGGEALEPEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRADLDASRSPIGAAIP 715 GEAL + + + + L N+YG TE + VT+ + DA PIG I Sbjct: 775 CSGEALPADAQQQVFAKL--PQAGLYNLYGPTEAAIDVTHWTCVEEGKDA--VPIGRPIA 830 Query: 716 DLGLYVLDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLY 775 +L Y+LD L P GV GELY++G GLARGY R L+AERFVA+PF G R+Y Sbjct: 831 NLACYILDGNLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFV----AGERMY 886 Query: 776 RTGDLVRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATP 835 RTGDL R+R DG ++Y GRID QVK+RG RIELGEIEA+LL P V A V+ Sbjct: 887 RTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLA---VDGK 943 Query: 836 RLVGY--LSPQAGIAPEALDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKAL 893 +LVGY L + G E AL L LP+YMVPA + L +PL+ NGK+DRKAL Sbjct: 944 QLVGYVVLESEGGDWRE-----ALAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKAL 998 Query: 894 PAPELA-ARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRAR 952 PAPE++ A+ Y+AP+ A+E LA IW+++L VG DDNFF LGGDSI+S+Q+VSRAR Sbjct: 999 PAPEVSVAQAGYSAPRNAVERTLAEIWQDLLGVEQVGLDDNFFSLGGDSIVSIQVVSRAR 1058 Query: 953 RAGIAITARQMFERQTVAELAAVASEAVAAATPRAITHTAQAGQACRLLPIQQDFFEADI 1012 +AG+ ++ R +F+ Q + LA A A A L P+Q+ FFE I Sbjct: 1059 QAGLQLSPRDLFQHQNIRSLALAAKAGAAT------AEQGPASGEVALAPVQRWFFEQSI 1112 Query: 1013 PRRAHWNQSVLLHSDAPIDPAALAAALHALMQAHPALTMRYAQHSDGWHQLHGELPTLQA 1072 P R HWNQS+LL + P+D L AL L H AL +R+ + WHQ + E QA Sbjct: 1113 PNRQHWNQSLLLQARQPLDGDRLGRALERLQAQHDALRLRFREERGAWHQAYAE----QA 1168 Query: 1073 IAERIVSARAADAEQLLALCESAQRSLDLEHGLVLRAVLVDMGQAGWRLLLVAHHLVIDG 1132 E + +A E LLALCE AQRSLDLE G +LRA+LVDM RLLLV HHL +DG Sbjct: 1169 -GEPLWRRQAGSEEVLLALCEEAQRSLDLEQGPLLRALLVDMADGSQRLLLVIHHLAVDG 1227 Query: 1133 VSWRVLLEDMQHAYAHACATPEQPLQLPAEEAGLAEWGEALAAYAPVAAQRIDHWLG-LA 1191 VSWR+LLED+Q YA A L + W L A +D+W L Sbjct: 1228 VSWRILLEDLQRLYADLDA------DLGPRSSSYQAWSRHLHEQAGARLDELDYWQAQLH 1281 Query: 1192 GCPVQLPSDPARAGEEGASARLADQQSVLLRLTPALTQTLIGEAHSAWRTQVNDLLLAAL 1251 P LP + E R ++L L T+ L+ EA +A+RTQVNDLLL AL Sbjct: 1282 DAPHALPCENPHGALENRHER-----KLVLTLDAERTRQLLQEAPAAYRTQVNDLLLTAL 1336 Query: 1252 ARALAAWGAPQPLLVDLEGHGREALGDGAATPDLSRTVGWFTSVFPLALEASGTPLATLL 1311 ARA W +LV LEGHGRE LG+ DLSRTVGWFTS+FPL L + +L Sbjct: 1337 ARATCRWSGDASVLVQLEGHGREDLGEAI---DLSRTVGWFTSLFPLRLTPAADLGESLK 1393 Query: 1312 RTKESLRALPNKGLDFGVLLRFGTAEQRDALQALPRAQVAFNYLGQFQSGEEGGWRL--A 1369 KE LR +P+KG+ +G+L E L ALP+ ++ FNYLG+F +G L A Sbjct: 1394 AIKEQLRGVPDKGVGYGLLRYLAGEEAATRLAALPQPRITFNYLGRFDRQFDGAALLVPA 1453 Query: 1370 SESAGTPMDPHAAMRHALTINGQVHEGVLQLRLNYCGKRYGRAMVETLAAHLQTQLEELA 1429 +ESAG DP A + + L+I GQV+ G L L ++ + + A V+ L +L L Sbjct: 1454 TESAGAAQDPCAPLANWLSIEGQVYGGELSLHWSFSREMFAEATVQRLVDDYARELHALI 1513 Query: 1430 ALC-SQHAGGLTPSDLPLAGLDQAQLD 1455 C G+TPSD PLAGL Q QLD Sbjct: 1514 EHCLDPRHRGVTPSDFPLAGLSQTQLD 1540 Score = 804 bits (2076), Expect = 0.0, Method: Compositional matrix adjust. Identities = 564/1403 (40%), Positives = 765/1403 (54%), Gaps = 119/1403 (8%) Query: 1470 LSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGF---- 1524 LS Q M F EP AY V ++G LD E+A+ V H+ LRT F Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 1525 ---LHQP---RPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGFDLAAPP 1578 L Q RPL+ VA S L + D ++A L AQR+ Q FDL P Sbjct: 112 DDSLAQAPLQRPLE-VAFEDCSGLPE-DEQEA--------RLREEAQRESLQPFDLCEGP 161 Query: 1579 LMRLVLVRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYR 1638 L+R+ L+R G +RH L+ T+HH++ DGWS ++L+ E R Y+ + L ++Y Sbjct: 162 LLRVRLIRLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYA 221 Query: 1639 DYI----GWLQGRDQEATRRFWEIQLARLQQPTRLADAMPRPSTPQSGHGEHRELLDATL 1694 DY WL+ +QE +W +L L PRP+ P + ++ L Sbjct: 222 DYALWQRSWLEAGEQERQLEYWRGKLGERHPVLELPTDHPRPAVPSYRGSRYEFSIEPAL 281 Query: 1695 TARLNEAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLG 1754 L AR Q +TL L+ + +LLQRY+ + G +A R VE L+G Sbjct: 282 AEALRGTARRQGLTLFMLLLGGFNILLQRYS---GQTDLRVGVPIANR--NRAEVEGLIG 336 Query: 1755 LFINTLPVIVATPPHQPAGDWMRALQAQNLQAREYEHTPLVDIQRWSGQGAQALFDSIL- 1813 LF+NT + + L+ L A+ ++ P + + + ++L S L Sbjct: 337 LFVNTQVLRSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVE-AFKVERSLSHSPLF 395 Query: 1814 --VFENYPVDATLSQ-GAPAGLAFSSVRHREETN-YPMTV-VVNAGDTLQLQLRYARAQF 1868 ++ + P+ A + + AGL+F + + T + +++ G L L YA F Sbjct: 396 QVMYNHQPLVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYEKGGRLYAALTYATDLF 455 Query: 1869 AHEMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDE----LAAWRESGVNRELHAFDAP 1924 VER+ H ++LL+ + E+PQ ++ SL +L +E L W + + Sbjct: 456 EARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAE---YPLQRG 512 Query: 1925 VHRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAP 1984 VHRL E Q TP+A AL + + LDY LN++ANRLAH L+ G G +R+VGVA R+ Sbjct: 513 VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSI 572 Query: 1985 EMVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELTAPAAVRVLE 2044 EMVVAL+A+LKAG AY+P+DP+ P R A M+ DSG+ LLL+Q+ L+ L V+ ++ Sbjct: 573 EMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLPLAQ--GVQRID 630 Query: 2045 LDAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAY 2104 LD W E +++PG+E+ + LAYVIYTSGSTGKPKGAGNRH +L NRL WMQ+AY Sbjct: 631 LDQ-ADAWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAY 689 Query: 2105 PIGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLH 2164 +G G+TVLQKTPF FDVSVWEFFWPLM+GARL +AAP +HRDPA L I R VDTLH Sbjct: 690 GLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLH 749 Query: 2165 FVPSMLQAFVAHPDSAQCHSLRQVICSGEALPAELQEQAFARLPQIALHNLYGPTEAAID 2224 FVPSMLQAF+ D A C SL++++CSGEALPA+ Q+Q FA+LPQ L+NLYGPTEAAID Sbjct: 750 FVPSMLQAFLQDEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTEAAID 809 Query: 2225 VTHWTC-RPGERSVPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGRPGL 2283 VTHWTC G+ +VPIGRPI++ A Y+LDG L P+P G+ GELYL G GLARGY RPGL Sbjct: 810 VTHWTCVEEGKDAVPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGYHQRPGL 869 Query: 2284 SAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLLA 2343 +AERFVA PF A G RMYRTGDL R RADG IEY GR DHQVK+RGLRIELGEIEA+LL Sbjct: 870 TAERFVASPFVA-GERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLE 928 Query: 2344 QPGVAAAVVVALVEPGRPARLVGYAA-DPGGMLEAEALRAALLQSLPDYMVPQRLILLPA 2402 P V A V+A+ G+ +LVGY + G EAL A L SLP+YMVP + + L Sbjct: 929 HPWVREAAVLAV--DGK--QLVGYVVLESEGGDWREALAAHLATSLPEYMVPAQWLALER 984 Query: 2403 LPLNANGKVDRKALPRPDFN-EQGGYEAPQGQTEIGLAAIWAEVLRLQRVGRHDNFFELG 2461 +PL+ NGK+DRKALP P+ + Q GY AP+ E LA IW ++L +++VG DNFF LG Sbjct: 985 MPLSPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQDLLGVEQVGLDDNFFSLG 1044 Query: 2462 GDSILSLQIVARAHEQGWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQAVTAARGRLEDY 2521 GDSI+S+Q+V+RA + G L+PR LFQ Q + LA Sbjct: 1045 GDSIVSIQVVSRARQAGLQLSPRDLFQHQNIRSLAL------------------------ 1080 Query: 2522 LSAAQTAQLALQGELEDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVRV-EGLDEARFAQ 2580 +A A A QG L+P+Q+ F P + L ++ + LD R + Sbjct: 1081 -AAKAGAATAEQGPASGEVALAPVQR--WFFEQSIPNRQHWNQSLLLQARQPLDGDRLGR 1137 Query: 2581 AWQSVLARHPVMRTGF-----LWQAGYA-QPLQAVWRTLAFGIEVQDWSARADDAELPQA 2634 A + + A+H +R F W YA Q + +WR A EV A ++A+ Sbjct: 1138 ALERLQAQHDALRLRFREERGAWHQAYAEQAGEPLWRRQAGSEEV--LLALCEEAQ---- 1191 Query: 2635 IAAFAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAY 2694 R DL Q PL+RA L+ + G +L+ +HH+ +DG S L+++L Y Sbjct: 1192 ----------RSLDLEQGPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLY 1241 Query: 2695 GGQPLPAP-GPDYAQYIGWLATLDPQAAQR-----YWMGALQALDGPSLL-AEGVRPDPA 2747 L A GP + Y W L QA R YW L D P L E Sbjct: 1242 AD--LDADLGPRSSSYQAWSRHLHEQAGARLDELDYWQAQLH--DAPHALPCENPHGALE 1297 Query: 2748 RRGFGKLYGHCDAAATRRLEQFA-RSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSG 2806 R KL DA TR+L Q A + R +N L+ A + A R +V G Sbjct: 1298 NRHERKLVLTLDAERTRQLLQEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHG 1357 Query: 2807 RPAALPGVE--KSLGLFINTIPI 2827 R ++ +++G F + P+ Sbjct: 1358 REDLGEAIDLSRTVGWFTSLFPL 1380 Score = 510 bits (1314), Expect = e-143, Method: Compositional matrix adjust. Identities = 396/1074 (36%), Positives = 553/1074 (51%), Gaps = 79/1074 (7%) Query: 2542 LSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTGF---- 2596 LS QQ M F P SG Y +VR+ G LD +A+ S++ RH +RT F Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 2597 ---LWQAGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPP 2653 L QA +PL+ + +D S +D E + A + + FDL + P Sbjct: 112 DDSLAQAPLQRPLE---------VAFEDCSGLPED-EQEARLREEAQRESLQPFDLCEGP 161 Query: 2654 LVRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAY-----GGQP-LPAPGPDYA 2707 L+R L+RLG +H L+ T+HHI+ DGWS + L++E Y G +P LPA YA Sbjct: 162 LLRVRLIRLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYA 221 Query: 2708 QYI----GWLATLDPQAAQRYWMGALQALDGPSLLAEGVRPDPARRGF-GKLYGHC-DAA 2761 Y WL + + YW G L P L P PA + G Y + A Sbjct: 222 DYALWQRSWLEAGEQERQLEYWRGKL-GERHPVLELPTDHPRPAVPSYRGSRYEFSIEPA 280 Query: 2762 ATRRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLF 2821 L AR Q +TL L+ G +++ L R+ T + G ++ R A VE +GLF Sbjct: 281 LAEALRGTARRQGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRA--EVEGLIGLF 338 Query: 2822 INTIPIVVEVDGQRRVGDWLRTLQQTNIDSREHEHTPL------YDIQRWSGMAGRALFD 2875 +NT + DG+ V L L+ T + ++ H+ P + ++R ++ LF Sbjct: 339 VNTQVLRSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVER--SLSHSPLFQ 396 Query: 2876 SIIVFENFPISRSLEA-RAQAGLRFGQAEGEG-LTGFAMDLQVVARE-TLDIEFCYDRSL 2932 +++ + P+ +EA + AGL FGQ + + T F + L + L Y L Sbjct: 397 --VMYNHQPLVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYEKGGRLYAALTYATDL 454 Query: 2933 FGDAELEALREQVMLNLDALSASGERALGELARLSPQALAAVLELGRGTH-DYPADLPAH 2991 F +E + L + + + ++ L L + +LE T +YP H Sbjct: 455 FEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVH 514 Query: 2992 LLIARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDM 3051 L + TP A AL E+ L Y ELN RANRLAH L+ GVGA++ VGVA+ERS +M Sbjct: 515 RLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEM 574 Query: 3052 VVGLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLA 3111 VV L+A++KAG AYVP+D +YP ER AYM+ DS +Q+LL+ + + LA G++ + Sbjct: 575 VVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLPLAQ----GVQRID 630 Query: 3112 LDDADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAAL 3171 LD AD A L ++P V + + +AYVIYTSGSTG+PKG H L Sbjct: 631 LDQAD--AWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQA 688 Query: 3172 YEMTPQWRELQFMSFSFDGAHERWITTLISGAALVLRGP-EMWSIEQSWQALHQQRVSNA 3230 Y + LQ FSFD + + L+SGA LV+ P + + + ++++ V Sbjct: 689 YGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTL 748 Query: 3231 VFPPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTETV 3290 F P+ L Q E L+ V GEA+P + ++V L L N YGPTE Sbjct: 749 HFVPSMLQAFLQ-DEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTEAA 807 Query: 3291 VTPLIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARG 3350 + W V+ VPIG+P+ YILD L+PV G GELY+ G GLARG Sbjct: 808 IDVTHW-----TCVEEGKDAVPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARG 862 Query: 3351 YLERPAQSAERFVADPFGEPGARMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGE 3410 Y +RP +AERFVA PF G RMYRTGDLAR+ DG +EY GR+DHQVK+RG RIELGE Sbjct: 863 YHQRPGLTAERFVASPF-VAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGE 921 Query: 3411 IEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQRDFSDSLRAALR 3470 IEA L P V EAAV+ DG +QLV YV E+ D+ ++L A L Sbjct: 922 IEARLLEHPWVREAAVLA-VDG------KQLVGYV-------VLESEGGDWREALAAHLA 967 Query: 3471 AGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPARS-YVAPATPAAQALAEIWQT 3529 LPEYM+PA ++ L +P++ NGKLDRKALPAP+ + A++ Y AP + LAEIWQ Sbjct: 968 TSLPEYMVPAQWLALERMPLSPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQD 1027 Query: 3530 VLKRERVGQEDNFFELGGDSLLCLQVIARARGQRQWNFNFKLADLMQRPTIAAL 3583 +L E+VG +DNFF LGGDS++ +QV++RA RQ DL Q I +L Sbjct: 1028 LLGVEQVGLDDNFFSLGGDSIVSIQVVSRA---RQAGLQLSPRDLFQHQNIRSL 1078 >PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1495 Score = 957 bits (2474), Expect = 0.0, Method: Compositional matrix adjust. Identities = 624/1450 (43%), Positives = 839/1450 (57%), Gaps = 61/1450 (4%) Query: 18 QRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDAWSNPLVIRDLAE 77 QR+ EE++ FDL + L VRL+AL QEHVLVI HHIVSD WS +++ +L + Sbjct: 95 QRVAEEIR----QPFDLARGPLLRVRLLALAGQEHVLVITQHHIVSDGWSMQVMVDELLQ 150 Query: 78 AYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLGPVNSSLDLPTDR 137 AY ARR Q L L +QYADYA W R + A +L YW + LG L+LP DR Sbjct: 151 AYAAARRGEQPTLAPLTLQYADYAAWHRAWLDSGEGARQLDYWRERLGAEQPVLELPADR 210 Query: 138 PRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLLSRYSGQADFFFF 197 RPA+ S RG L +L++++ A R + TPF+ L+A++QVLL RYSGQ+D Sbjct: 211 VRPAQASGRGQRLDMALPVSLSEELLACARREGVTPFMLLLASFQVLLKRYSGQSDIRVG 270 Query: 198 --FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAALEHGDLPFEALL 255 A RN AE++ L+GFFV TQ+ R ++ L R+L+ +VR L A H DLPFE L+ Sbjct: 271 VPIANRNRAEVERLIGFFVNTQVLRCQVDAGLAFRDLLGRVREAALGAQAHQDLPFEQLV 330 Query: 256 EHRKVERDPGRNPLFQVMFGLQMVGEGASALAFDDIVTAPLPLAQDSAKFDLSLDVKVIK 315 + + ER+ +PLFQVM+ Q GE A D + +A+FDL+LD Sbjct: 331 DALQPERNLSHSPLFQVMYNHQS-GERQDA-QVDGLHIESFAWDGAAAQFDLALDTWETP 388 Query: 316 GEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALLDQDEQARLRSWGD 375 + L YA+DLF+A T+ MA H+QNLLRG P+ V L +LD +E+ +L + Sbjct: 389 DGLGAALTYATDLFEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWN 448 Query: 376 PQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRAANRLAHRLLQQGV 435 E P G + L E Q P A A+ G +++ YA+LNR ANRLAH L+++GV Sbjct: 449 ATAAE-YPLQRG--VHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGV 505 Query: 436 GPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQDAGVTLALTAGEG 495 G + +G+A RS+EM+V L+AILKAG AYVP+DP+YP +R AYM++D+GV L L+ Sbjct: 506 GADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSH- 564 Query: 496 VSALTAQGLRTLEI--APALADDAAPAHNPGVVLHPDNLAYIIYTSGSTGRPKGAQLSHA 553 + AQG++ +++ A A ++ A +NPG+ L+ +NLAY+IYTSGSTG+PKGA H+ Sbjct: 565 LKLPLAQGVQRIDLDQADAWLENHA-ENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHS 623 Query: 554 NVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVVVPFAVSRSPEDF 613 + L + G D ++FD SVWE F L G RLVV R P Sbjct: 624 ALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKL 683 Query: 614 LALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEALEPEMLRPWITQF 673 +AL+ + V L+ PS + LQ + S L+ ++ GEAL + + + Sbjct: 684 VALINREGVDTLHFVPSMLQAFLQDEDVVSCTS----LKRIVCSGEALSADAQQQVFAKL 739 Query: 674 GDQRPALINMYGITETTVHVTYRRLLRADLDASRSPIGAAIPDLGLYVLDQRLNLAPAGV 733 + L N+YG TE + VT+ + DA PIG I +LG Y+LD L P GV Sbjct: 740 --PQAGLYNLYGPTEAAIDVTHWSCVEEGKDA--VPIGRPIANLGCYILDGDLEPVPVGV 795 Query: 734 PGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLVRWRHDGQMDYLG 793 GELY++G GLARGY R L+AERFVA+PF G R+YRTGDL R+R DG ++Y G Sbjct: 796 LGELYLAGRGLARGYHQRPGLTAERFVASPFV----AGERMYRTGDLARYRADGVIEYAG 851 Query: 794 RIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGY--LSPQAGIAPEA 851 RID QVK+RG RIELGEIEA+LL P V A V+ + +LVGY L + G E Sbjct: 852 RIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLA---VDSRQLVGYVVLESEGGDWRE- 907 Query: 852 LDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAPELAARTAYAAPQGAL 911 AL L LP+YMVPA + L +PL+ NGK+DRKALP P+ AA + APQ + Sbjct: 908 ----ALAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKALPRPQAAAGQTHVAPQNEM 963 Query: 912 EEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRARRAGIAITARQMFERQTVAE 971 E ++AA+W +VLK VG DNFF LGGDSI+S+Q+VSR R AGI T + +F++QTV Sbjct: 964 ERRIAAVWADVLKLEEVGATDNFFALGGDSIVSIQVVSRCRAAGIQFTPKDLFQQQTVQG 1023 Query: 972 LAAVASEAVAAATPRAITHTAQAGQACRLLPIQQDFFEADIPRRAHWNQSVLLHSDAPID 1031 LA VA V AA + +G+ LLP Q+ FFE IP R HWNQS+LL ++ Sbjct: 1024 LARVAR--VGAAV--QMEQGPVSGETV-LLPFQRLFFEQPIPNRQHWNQSLLLKPREALN 1078 Query: 1032 PAALAAALHALMQAHPALTMRYAQHSDGWHQLHGELPTLQAIAERIVSARAADAEQLLAL 1091 AL AAL AL++ H AL +R+ + WH H E A+ R A A D + L +L Sbjct: 1079 AKALEAALQALVEHHDALRLRFHETDGTWHAEHAEATLGGALLWR---AEAVDRQALESL 1135 Query: 1092 CESAQRSLDLEHGLVLRAVLVDMGQAGWRLLLVAHHLVIDGVSWRVLLEDMQHAYAHACA 1151 CE +QRSLDL G +LR++LVDM G RLLLV HHLV+DGVSWR+LLED+Q AY + Sbjct: 1136 CEESQRSLDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLEDLQRAYQQSLR 1195 Query: 1152 TPEQPLQLPAEEAGLAEWGEALAAYAPVAAQR--IDHWLG-LAGCPVQLPSDPARAGEEG 1208 E P +LP + + W ++ +A + + + W L G P +LP + + E Sbjct: 1196 G-EAP-RLPGKTSPFKAWAGRVSEHARGESMKAQLQFWRELLEGAPAELPCEHPQGALEQ 1253 Query: 1209 ASARLADQQSVLLRLTPALTQTLIGEAHSAWRTQVNDLLLAALARALAAWGAPQPLLVDL 1268 A SV R +LT+ L+ +A +A+RTQVNDLLL ALAR + W LV L Sbjct: 1254 RFA-----TSVQSRFDRSLTERLLKQAPAAYRTQVNDLLLTALARVVCRWSGASSSLVQL 1308 Query: 1269 EGHGREALGDGAATPDLSRTVGWFTSVFPLALEASGTPLATLLRTKESLRALPNKGLDFG 1328 EGHGRE L A DLSRTVGWFTS+FP+ L +L KE LRA+P+KGL +G Sbjct: 1309 EGHGREEL---FADIDLSRTVGWFTSLFPVRLSPVADLGESLKAIKEQLRAIPDKGLGYG 1365 Query: 1329 VLLRFGTAEQRDALQALPRAQVAFNYLGQF--QSGEEGGWRLASESAGTPMDPHAAMRHA 1386 +L E L LP+A++ FNYLGQF Q E A ESAG MDP A + + Sbjct: 1366 LLRYLAGEESARVLAGLPQARITFNYLGQFDAQFDEMALLDPAGESAGAEMDPGAPLDNW 1425 Query: 1387 LTINGQVHEGVLQLRLNYCGKRYGRAMVETLAAHLQTQLEELAALCSQHA-GGLTPSDLP 1445 L++NG+V +G L + ++ + +G V LA +L L C G TPSD P Sbjct: 1426 LSLNGRVFDGELSIDWSFSSQMFGEDQVRRLADDYVAELTALVDFCCDSPRHGATPSDFP 1485 Query: 1446 LAGLDQAQLD 1455 LAGLDQA+LD Sbjct: 1486 LAGLDQARLD 1495 Score = 759 bits (1961), Expect = 0.0, Method: Compositional matrix adjust. Identities = 523/1271 (41%), Positives = 705/1271 (55%), Gaps = 130/1271 (10%) Query: 1469 PLSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGFLHQ 1527 PLS Q M F EP +AY + + G LD A +QA+ V H+ LRT F Sbjct: 5 PLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRF--- 61 Query: 1528 PRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQR---QLAQGFDLAAPPLMRLVL 1584 + AR+ + L+ + R A G L QR ++ Q FDLA PL+R+ L Sbjct: 62 -EEVDGQARQ--TILANMPLRIVLEDCA-GASEATLRQRVAEEIRQPFDLARGPLLRVRL 117 Query: 1585 VRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYRDYIGWL 1644 + Q H L+ T HH++ DGWS +++ E+L+ YA A Q L L+Y DY W Sbjct: 118 LALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWH 177 Query: 1645 QG--RDQEATRR--FWEIQLARLQQPTRLADAMPRPSTPQSGHGEHREL-LDATLTARLN 1699 + E R+ +W +L Q L RP+ SG G+ ++ L +L+ L Sbjct: 178 RAWLDSGEGARQLDYWRERLGAEQPVLELPADRVRPAQA-SGRGQRLDMALPVSLSEELL 236 Query: 1700 EAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINT 1759 AR + +T L+ A++ +LL+RY+ + + G +A R VE+L+G F+NT Sbjct: 237 ACARREGVTPFMLLLASFQVLLKRYSGQSD---IRVGVPIANR--NRAEVERLIGFFVNT 291 Query: 1760 LPV--------------------IVATPPHQ--PAGDWMRALQAQNLQAREYEHTPLVDI 1797 + + HQ P + ALQ + R H+PL + Sbjct: 292 QVLRCQVDAGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPE----RNLSHSPLFQV 347 Query: 1798 --QRWSGQGAQALFDSILVFENYPVDATLSQGAPAGLAFSSVRHREETNYPMTVVVNAGD 1855 SG+ A D + + E++ D +Q F ET D Sbjct: 348 MYNHQSGERQDAQVDGLHI-ESFAWDGAAAQ-------FDLALDTWETP----------D 389 Query: 1856 TLQLQLRYARAQFAHEMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDE----LAAWRE 1911 L L YA F VER+ H ++LL+ + E+PQ ++ SL +L +E L W Sbjct: 390 GLGAALTYATDLFEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNA 449 Query: 1912 SGVNRELHAFDAPVHRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAG 1971 + + VHRL E Q TP+A AL + + LDY LN++ANRLAH L+ G G Sbjct: 450 TAAE---YPLQRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVG 506 Query: 1972 PERIVGVAARRAPEMVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALR 2031 +R+VGVA R+ EMVVAL+A+LKAG AY+P+DP+ P R A M+ DSG+ LLL+Q+ L+ Sbjct: 507 ADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLK 566 Query: 2032 AELTAPAAVRVLELDAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHV 2091 L V+ ++LD W E +++PGIE+ + LAYVIYTSGSTGKPKGAGNRH Sbjct: 567 LPLAQ--GVQRIDLDQ-ADAWLENHAENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHS 623 Query: 2092 SLHNRLAWMQEAYPIGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALL 2151 +L NRL WMQ+AY +G G+TVLQKTPF FDVSVWEFFWPLM+GARL +AAP +HRDPA L Sbjct: 624 ALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKL 683 Query: 2152 AARIRRHAVDTLHFVPSMLQAFVAHPDSAQCHSLRQVICSGEALPAELQEQAFARLPQIA 2211 A I R VDTLHFVPSMLQAF+ D C SL++++CSGEAL A+ Q+Q FA+LPQ Sbjct: 684 VALINREGVDTLHFVPSMLQAFLQDEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAG 743 Query: 2212 LHNLYGPTEAAIDVTHWTC-RPGERSVPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGG 2270 L+NLYGPTEAAIDVTHW+C G+ +VPIGRPI++ Y+LDG L P+P G+ GELYL G Sbjct: 744 LYNLYGPTEAAIDVTHWSCVEEGKDAVPIGRPIANLGCYILDGDLEPVPVGVLGELYLAG 803 Query: 2271 IGLARGYLGRPGLSAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGL 2330 GLARGY RPGL+AERFVA PF A G RMYRTGDL R RADG IEY GR DHQVK+RGL Sbjct: 804 RGLARGYHQRPGLTAERFVASPFVA-GERMYRTGDLARYRADGVIEYAGRIDHQVKLRGL 862 Query: 2331 RIELGEIEAQLLAQPGVAAAVVVALVEPGRPARLVGYAA-DPGGMLEAEALRAALLQSLP 2389 RIELGEIEA+LL P V A V+A+ +LVGY + G EAL A L SLP Sbjct: 863 RIELGEIEARLLEHPWVREAAVLAV----DSRQLVGYVVLESEGGDWREALAAHLATSLP 918 Query: 2390 DYMVPQRLILLPALPLNANGKVDRKALPRPDFNEQGGYEAPQGQTEIGLAAIWAEVLRLQ 2449 +YMVP + + L +PL+ NGK+DRKALPRP + APQ + E +AA+WA+VL+L+ Sbjct: 919 EYMVPAQWLALERMPLSPNGKLDRKALPRPQAAAGQTHVAPQNEMERRIAAVWADVLKLE 978 Query: 2450 RVGRHDNFFELGGDSILSLQIVARAHEQGWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQ 2509 VG DNFF LGGDSI+S+Q+V+R G TP+ LFQ QTV LA Sbjct: 979 EVGATDNFFALGGDSIVSIQVVSRCRAAGIQFTPKDLFQQQTVQGLA------------- 1025 Query: 2510 AVTAARGRLEDYLSAAQTAQLALQGELEDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVR 2569 R+ +A Q Q + GE L P Q+ LF P + L ++ Sbjct: 1026 -------RVARVGAAVQMEQGPVSGET----VLLPFQR--LFFEQPIPNRQHWNQSLLLK 1072 Query: 2570 -VEGLDEARFAQAWQSVLARHPVMRTGF-----LWQAGYAQPLQAVWRTLAFGIEVQDWS 2623 E L+ A Q+++ H +R F W A +A+ TL + W Sbjct: 1073 PREALNAKALEAALQALVEHHDALRLRFHETDGTWHAEHAEA------TLGGALL---WR 1123 Query: 2624 ARADDAELPQAIAAFAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWST 2683 A A D + +++ + R DL PL+R+ L+ + G +L+ +HH+++DG S Sbjct: 1124 AEAVDRQALESL----CEESQRSLDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSW 1179 Query: 2684 SALMQELMLAY 2694 L+++L AY Sbjct: 1180 RILLEDLQRAY 1190 Score = 484 bits (1247), Expect = e-135, Method: Compositional matrix adjust. Identities = 396/1092 (36%), Positives = 547/1092 (50%), Gaps = 85/1092 (7%) Query: 2541 PLSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTGFLWQ 2599 PLS QQ M F P S Y + V G LD+A QA+ ++ RH +RT F Sbjct: 5 PLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRFEEV 64 Query: 2600 AGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPLVRATL 2659 G A+ Q + + I ++D A A +A L Q +A ++ + FDL + PL+R L Sbjct: 65 DGQAR--QTILANMPLRIVLED-CAGASEATLRQRVAE----EIRQPFDLARGPLLRVRL 117 Query: 2660 LRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAY-----GGQPLPAP-GPDYAQYIGW- 2712 L L +H LV T HHI+ DGWS ++ EL+ AY G QP AP YA Y W Sbjct: 118 LALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWH 177 Query: 2713 LATLDPQAAQR---YW---MGALQALDGPSLLAEGVRPDPARRGFGKLYGHCDAAATRRL 2766 A LD R YW +GA Q + L A+ VRP A +L + + L Sbjct: 178 RAWLDSGEGARQLDYWRERLGAEQPV--LELPADRVRPAQASGRGQRLDMALPVSLSEEL 235 Query: 2767 EQFARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFINTIP 2826 AR + VT L+ ++ + L R+ + + G ++ R A VE+ +G F+NT Sbjct: 236 LACARREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRA--EVERLIGFFVNTQV 293 Query: 2827 IVVEVDGQRRVGDWLRTLQQTNIDSREHEHTPLYDIQRWSGMAGRALFDSIIVFENF--- 2883 + +VD D L +++ + ++ H+ P L D++ N Sbjct: 294 LRCQVDAGLAFRDLLGRVREAALGAQAHQDLPF-----------EQLVDALQPERNLSHS 342 Query: 2884 PISRSLEARAQAGLRFGQAEGEGLTGFA-------MDLQVVARETLD---IEFCYDRSLF 2933 P+ + + + Q +G + FA DL + ET D Y LF Sbjct: 343 PLFQVMYNHQSGERQDAQVDGLHIESFAWDGAAAQFDLALDTWETPDGLGAALTYATDLF 402 Query: 2934 GDAELEALREQVMLNLDALSASGERALGELARLSPQALAAVLELGRGTH-DYPADLPAHL 2992 +E + L + + + ++ L L + +LE T +YP H Sbjct: 403 EARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHR 462 Query: 2993 LIARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMV 3052 L + TP A AL E+ L Y ELN RANRLAH L+ GVGA++ VGVA+ERS +MV Sbjct: 463 LFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMV 522 Query: 3053 VGLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLAL 3112 V L+A++KAG AYVP+D +YP ER AYM+ DS +Q+LL+ + + LA G++ + L Sbjct: 523 VALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLPLAQ----GVQRIDL 578 Query: 3113 DDADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALY 3172 D AD A L ++P + + + +AYVIYTSGSTG+PKG H L Y Sbjct: 579 DQAD--AWLENHAENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAY 636 Query: 3173 EMTPQWRELQFMSFSFDGAHERWITTLISGAALVLRGPEMWSIEQSWQAL-HQQRVSNAV 3231 + LQ FSFD + + L+SGA LV+ P AL +++ V Sbjct: 637 GLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLH 696 Query: 3232 FPPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTETVV 3291 F P+ L Q E L+ V GEA+ + ++V L L N YGPTE + Sbjct: 697 FVPSMLQAFLQ-DEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTEAAI 755 Query: 3292 TPLIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARGY 3351 W + V+ VPIG+P+ YILD L+PV G GELY+ G GLARGY Sbjct: 756 DVTHW-----SCVEEGKDAVPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGY 810 Query: 3352 LERPAQSAERFVADPFGEPGARMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGEI 3411 +RP +AERFVA PF G RMYRTGDLAR+ DG +EY GR+DHQVK+RG RIELGEI Sbjct: 811 HQRPGLTAERFVASPF-VAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEI 869 Query: 3412 EALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQRDFSDSLRAALRA 3471 EA L P V EAAV+ RQLV YV E+ D+ ++L A L Sbjct: 870 EARLLEHPWVREAAVLAVDS-------RQLVGYV-------VLESEGGDWREALAAHLAT 915 Query: 3472 GLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPARSYVAPATPAAQALAEIWQTVL 3531 LPEYM+PA ++ L +P++ NGKLDRKALP PQAA +++VAP + +A +W VL Sbjct: 916 SLPEYMVPAQWLALERMPLSPNGKLDRKALPRPQAAAGQTHVAPQNEMERRIAAVWADVL 975 Query: 3532 KRERVGQEDNFFELGGDSLLCLQVIARARGQRQWNFNFKLADLMQRPTIAALLGLESRLA 3591 K E VG DNFF LGGDS++ +QV++R R F DL Q+ T+ L +R+A Sbjct: 976 KLEEVGATDNFFALGGDSIVSIQVVSRCRAA---GIQFTPKDLFQQQTVQGL----ARVA 1028 Query: 3592 DGPALVAMNAGP 3603 A V M GP Sbjct: 1029 RVGAAVQMEQGP 1040 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 920 bits (2377), Expect = 0.0, Method: Compositional matrix adjust. Identities = 633/1491 (42%), Positives = 828/1491 (55%), Gaps = 87/1491 (5%) Query: 1 VQLAWLDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHH 60 + + W D L R+Q LQ + A FDL L V ++ + +EH LV+ +HH Sbjct: 83 LHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCMVKMAEREHYLVVTLHH 142 Query: 61 IVSDAWSNPLVIRDLAEAYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYW 120 IV++ W+ + R+L Y D ++ L LP+QY DY+ WQR+ ++ +L YW Sbjct: 143 IVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQREWLESGERQRQLDYW 202 Query: 121 DDYLGPVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAA 180 LG + L+LP DRPRP QS +G ++ F L LA++++ F A+ T F+ + A Sbjct: 203 KAQLGNEHPLLELPGDRPRPPVQSHQGDLYRFDLSPELAERVRRFNAARGLTMFMTMTAT 262 Query: 181 WQVLLSRYSGQADFFFF--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRG 238 LL RYSGQ D A R E + L+G F+ TQ+ R RL +++V EL+ QVR Sbjct: 263 LAALLYRYSGQQDLRIGAPVANRIRPESEGLIGAFLNTQVLRCRLDGQMSVGELLEQVRQ 322 Query: 239 DMLAALEHGDLPFEALLEHRKVERDPGRNPLFQVMFGL---------QMVGEGASALAFD 289 ++ H DLPF+ L+E + R NPLFQVM + Q+ G +A D Sbjct: 323 TVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQTRQLAGMTVEYIAND 382 Query: 290 DIVTAPLPLAQDSAKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFA 349 T KFDL+L+V + + C L Y+ DLFD IA MAGH+QNLL Sbjct: 383 ARAT----------KFDLNLEVTDLDQRLGCCLTYSRDLFDEPRIARMAGHWQNLLEALL 432 Query: 350 AAPERPVAQLALLDQDEQARLR---SWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVA 406 P+R +A+L L +E+ +L + G+ L++ +L GL A+ AA P A A Sbjct: 433 GDPQRRIAELPLFAAEERKQLLLAGTAGEAGLQD--------TLHGLFAARVAASPQAPA 484 Query: 407 VVCGPQQMSYAQLNRAANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYV 466 + Q +SYA+L+ +NRLA L GVGPE R+GLA RSLEM+VGLLAILKAG AYV Sbjct: 485 LTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAILKAGGAYV 544 Query: 467 PLDPDYPADRLAYMVQDAGVTLALTAG---EGVSALTAQGLRTL--EIAPAL-ADDAAPA 520 PLDP+YP +RL YM++D+GV L L+ E + L A R E PAL A+D AP Sbjct: 545 PLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPALDAEDPAPL 604 Query: 521 HNPGVVLHPDNLAYIIYTSGSTGRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSY 580 + P + AY+IYTSGSTG+PKG +SH + F ED F+S Sbjct: 605 ---AALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCELHFYSI 661 Query: 581 AFDFSVWEIFGALCYGGRLVVVPFAVSRSPEDFLALLVEQRVTVLNQTPSAFRQLLQL-- 638 FD + + L G R VV+ E+ L+ + V++L TPS QL Q Sbjct: 662 NFDAASERLLAPLLCGAR-VVLRAQGQWGAEEICELIRAEGVSILGFTPSYGSQLAQWLE 720 Query: 639 PALRQLPSEALALRTVIFGGEALEPEMLRPWITQFGDQRPALINMYGITETTVH-VTYRR 697 RQLP +R I GGEAL E L+ F + N YG TET V + Sbjct: 721 SQGRQLP-----VRMCITGGEALTGEHLQRIRQAFAP--ASFFNAYGPTETVVMPLACLA 773 Query: 698 LLRADLDASRSPIGAAIPDLGLYVLDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAE 757 R + A+ PIG+ + Y+LD L L P G GELYV GAGLARGY R ALSAE Sbjct: 774 PERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYHERPALSAE 833 Query: 758 RFVANPFARAGEEGSRLYRTGDLVRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLA 817 RFV +PFA EG RLYRTGDLVR +GQ++Y+GRID QVKIRGFRIELGEIEA+LL Sbjct: 834 RFVPDPFA---AEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIEARLLE 890 Query: 818 QPGVGAATVMVRQDAATPRLVGYLSPQAGIAPEALDT-----GALRTALGAVLPDYMVPA 872 P V A V+ + +L GY++ + +A + D AL+T L LPDYMVPA Sbjct: 891 HPQVREALVLALDSPSGKQLAGYVA--SAVAEQDEDAQAALREALKTHLKQQLPDYMVPA 948 Query: 873 ALVVLPALPLNINGKVDRKALPAPELA-ARTAYAAPQGALEEQLAAIWREVLKGGAVGRD 931 L++L +LPL NGK+DR+ALPAP+ A R AY AP+ LE+QLA +WREVL VG Sbjct: 949 HLLLLASLPLTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAGVWREVLNVERVGLG 1008 Query: 932 DNFFELGGDSILSLQIVSRARRAGIAITARQMFERQTVAELAAVASEAVAAATPRAITHT 991 DNFFELGGDSILS+Q+VSRAR+ GI + R +F+ QTV LAAVA + A+ + Sbjct: 1009 DNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQSLAAVARHSQASQAEQGPVQG 1068 Query: 992 AQAGQACRLLPIQQDFFEADIPRRAHWNQSVLLHSDAPIDPAALAAALHALMQAHPALTM 1051 A L PIQ FF+ + RR HWNQ++LL ID L +L L++ H AL + Sbjct: 1069 DSA-----LTPIQHWFFDLPLARREHWNQALLLQPRQAIDLGLLRKSLQRLVEQHDALRL 1123 Query: 1052 RYAQHSDGWHQLHGELPTLQAIAERIVSARAADAEQLLALCESAQRSLDLEHGLVLRAVL 1111 + Q W H L + + V + AE L AQRSLDLE G +LRAVL Sbjct: 1124 AFRQVDGEWLAQHRPLREQELLWHVPVQSFDECAE----LFAKAQRSLDLEQGPLLRAVL 1179 Query: 1112 VDMGQAGWRLLLVAHHLVIDGVSWRVLLEDMQHAYAHACATPEQPLQLPAEEAGLAEWGE 1171 VD RLLL HHLV+DGVSWRVLLED+Q Y E LPA+ + +W Sbjct: 1180 VDGPAGEQRLLLAIHHLVVDGVSWRVLLEDLQQVYRQFAEGAEPA--LPAKTSAFRDWAG 1237 Query: 1172 ALAAYAPVAAQR--IDHWLG-LAGCPVQLPSDPARAGEEGASARLADQQSVLLRLTPALT 1228 L AYA + R + W L G PV+ P D + A A +SV LRL P T Sbjct: 1238 RLQAYAGSESLREELGWWQARLGGQPVEWPCDRPQGDNREALA-----ESVSLRLDPQRT 1292 Query: 1229 QTLIGEAHSAWRTQVNDLLLAALARALAAWGAPQPLLVDLEGHGREALGDGAATPDLSRT 1288 + L+ +A +A+RTQVNDLLL ALAR L W LV LEGHGREAL D DL+R+ Sbjct: 1293 RQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPSTLVQLEGHGREALFDDI---DLTRS 1349 Query: 1289 VGWFTSVFPLALEASGTPLATLLRTKESLRALPNKGLDFGVLLRFGTAEQRDALQALPRA 1348 VGWFTS +PL L + +P ++ KE LRA+P+KGL +GVL R A+ ALP A Sbjct: 1350 VGWFTSAYPLRLTPAQSPGESIKAIKEQLRAVPHKGLGYGVLRYLADPAVRQAMAALPTA 1409 Query: 1349 QVAFNYLGQF-QSGEEGGWRLASESAGTPMDPHAAMRHALTINGQVHEGVLQLRLNYCGK 1407 + FNYLGQF QS + ++ + G D A + + L+++GQV+ G L LR Y + Sbjct: 1410 PITFNYLGQFDQSFADALFQPLDQPTGPIHDEQAPLPNELSVDGQVYGGELVLRWTYSRE 1469 Query: 1408 RYGRAMVETLAAHLQTQLEELAALCSQH-AGGLTPSDLPLAGLDQAQLDAL 1457 RY V LA +L+ L C + AGGLTPSD PLA L QAQLDAL Sbjct: 1470 RYDARTVNELAQAYLAELQALIEHCLEDGAGGLTPSDFPLAQLSQAQLDAL 1520 Score = 588 bits (1516), Expect = e-167, Method: Compositional matrix adjust. Identities = 430/1073 (40%), Positives = 571/1073 (53%), Gaps = 55/1073 (5%) Query: 2537 EDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTG 2595 E PLS QQ M F P S Y R+ G LD ARF A Q+++ RH +RT Sbjct: 6 EQPVPLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTT 65 Query: 2596 FLWQAGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPLV 2655 F G P+Q V ++ QD+SA D+ Q + A ++ R FDL PL+ Sbjct: 66 FPSVDGV--PVQRVHGDGGLHMDWQDFSALDRDSR-QQHLQTLADSEAHRPFDLESGPLL 122 Query: 2656 RATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGG---------QPLPAPGPDY 2706 R ++++ +H LV T+HHI+ +GW+ +EL Y +PLP DY Sbjct: 123 RVCMVKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDY 182 Query: 2707 AQYI-GWLATLDPQAAQRYWMGALQALDGPSLLAEGVRPDPARRGF-GKLYGH-CDAAAT 2763 + + WL + + Q YW L + P L G RP P + G LY Sbjct: 183 SVWQREWLESGERQRQLDYWKAQL-GNEHPLLELPGDRPRPPVQSHQGDLYRFDLSPELA 241 Query: 2764 RRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFIN 2823 R+ +F ++ +T+ + + L R+ + GA V+ R P E +G F+N Sbjct: 242 ERVRRFNAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANR--IRPESEGLIGAFLN 299 Query: 2824 TIPIVVEVDGQRRVGDWLRTLQQTNIDSREHEHTPLYDI----QRWSGMAGRALFDSIIV 2879 T + +DGQ VG+ L ++QT ID + H+ P + Q A LF + Sbjct: 300 TQVLRCRLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCN 359 Query: 2880 FENFPISRSLEARAQAGLRFGQAEGEG-LTGFAMDLQVVA-RETLDIEFCYDRSLFGDAE 2937 + + ++ R AG+ + T F ++L+V + L Y R LF + Sbjct: 360 VQRWEFQQT---RQLAGMTVEYIANDARATKFDLNLEVTDLDQRLGCCLTYSRDLFDEPR 416 Query: 2938 LEALREQVMLNLDALSASGERALGELARLSPQALAAVLELGRGTHDYPADLPAHLLIARR 2997 + + L+AL +R + EL + + +L G D H L A R Sbjct: 417 IARMAGHWQNLLEALLGDPQRRIAELPLFAAEERKQLLLAGTAGEAGLQDT-LHGLFAAR 475 Query: 2998 AALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMVVGLLA 3057 A +P A AL Q+LSY EL+ R+NRLA L S GVG E RVG+A+ERS +MVVGLLA Sbjct: 476 VAASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLA 535 Query: 3058 VMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLR-CLALD--- 3113 ++KAG AYVPLD +YP ERL YM+ DS +++LL+HA L R CL D Sbjct: 536 ILKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPA 595 Query: 3114 -DADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALY 3172 DA+ A LA L PQ AY+IYTSGSTG+PKGVAVSHG + MHC A + Sbjct: 596 LDAEDPAPLAALSG--------PQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECF 647 Query: 3173 EMTPQWRELQFMSFSFDGAHERWITTLISGAALVLRGPEMWSIEQSWQALHQQRVSNAVF 3232 M + EL F S +FD A ER + L+ GA +VLR W E+ + + + VS F Sbjct: 648 GMRAEDCELHFYSINFDAASERLLAPLLCGARVVLRAQGQWGAEEICELIRAEGVSILGF 707 Query: 3233 PPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTETVVT 3292 P+Y QLAQW E G P+ + + GGEA+ +R+R+ AP N YGPTETVV Sbjct: 708 TPSYGSQLAQWLESQGRQLPVRMCITGGEALTGEHLQRIRQAFAPASFFNAYGPTETVVM 767 Query: 3293 PLIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARGYL 3352 PL + ++ VPIG VG R AYILDA L V G GELY+GG GLARGY Sbjct: 768 PL--ACLAPERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYH 825 Query: 3353 ERPAQSAERFVADPFGEPGARMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGEIE 3412 ERPA SAERFV DPF G R+YRTGDL R +G VEY+GR+DHQVKIRGFRIELGEIE Sbjct: 826 ERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIE 885 Query: 3413 ALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAA-PETAQRDFSDSLRAALRA 3471 A L P V EA V+ G +QL YV + AVA E AQ ++L+ L+ Sbjct: 886 ARLLEHPQVREALVLALDSPSG----KQLAGYVAS--AVAEQDEDAQAALREALKTHLKQ 939 Query: 3472 GLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPAR-SYVAPATPAAQALAEIWQTV 3530 LP+YM+PAH +LLA+LP+T NGKLDR+ALPAP A R +Y AP + Q LA +W+ V Sbjct: 940 QLPDYMVPAHLLLLASLPLTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAGVWREV 999 Query: 3531 LKRERVGQEDNFFELGGDSLLCLQVIARARGQRQWNFNFKLADLMQRPTIAAL 3583 L ERVG DNFFELGGDS+L +QV++RA RQ +F DL Q T+ +L Sbjct: 1000 LNVERVGLGDNFFELGGDSILSIQVVSRA---RQLGIHFSPRDLFQHQTVQSL 1049 Score = 523 bits (1346), Expect = e-147, Method: Compositional matrix adjust. Identities = 485/1415 (34%), Positives = 671/1415 (47%), Gaps = 121/1415 (8%) Query: 1469 PLSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGFLHQ 1527 PLS Q M F EP AY + G LD ARFE A Q V H+ LRT F Sbjct: 10 PLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTF--- 66 Query: 1528 PRPLQWVARRVASPLS-QLDWRDAAA--GQALGGELDALAQRQLAQGFDLAAPPLMRLVL 1584 P +RV +DW+D +A + L LA + + FDL + PL+R+ + Sbjct: 67 PSVDGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCM 126 Query: 1585 VRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYRDYI--- 1641 V+ + H+L+ T+HH++ +GW+ + E+ Y ++ L ++Y DY Sbjct: 127 VKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQ 186 Query: 1642 -GWLQGRDQEATRRFWEIQLARLQQPTRLADAMPRPSTPQSGHGE-HRELLDATLTARLN 1699 WL+ +++ +W+ QL L PRP QS G+ +R L L R+ Sbjct: 187 REWLESGERQRQLDYWKAQLGNEHPLLELPGDRPRPPV-QSHQGDLYRFDLSPELAERVR 245 Query: 1700 EAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINT 1759 A+ +T+ + A A LL RY+ Q + GA VA R + E L+G F+NT Sbjct: 246 RFNAARGLTMFMTMTATLAALLYRYS---GQQDLRIGAPVANRIRPES--EGLIGAFLNT 300 Query: 1760 LPVIVATPPHQPAGDWMRALQAQNLQAREYEHTP---LVD-IQRWSGQGAQALFDSILVF 1815 + G+ + ++ + + ++ P LV+ +Q LF + Sbjct: 301 QVLRCRLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNV 360 Query: 1816 ENYPVDATLSQGAPAGLAFSSVRHREE-TNYPMTVVVNAGDT-LQLQLRYARAQFAHEMV 1873 + + T AG+ + + T + + + V D L L Y+R F + Sbjct: 361 QRWEFQQTRQL---AGMTVEYIANDARATKFDLNLEVTDLDQRLGCCLTYSRDLFDEPRI 417 Query: 1874 ERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDELAAWRESGVNRELHAFDAPVHRLIERQA 1933 R+ H ++LL+ L PQ+ I L L +E +G E D +H L + Sbjct: 418 ARMAGHWQNLLEALLGDPQRRIAELPLFAAEERKQLLLAGTAGEAGLQDT-LHGLFAARV 476 Query: 1934 AATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAPEMVVALLAV 1993 AA+P A AL + L Y L+ ++NRLA L + G GPE VG+A R+ EMVV LLA+ Sbjct: 477 AASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAI 536 Query: 1994 LKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTAL---RAELTAPAAVRVLELDAPGQ 2050 LKAG AY+PLDP+ P RL M+ DSG+ LLL+ AL EL A A LE D P Sbjct: 537 LKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPA- 595 Query: 2051 PWAEGMPDHDPGIEVA---PDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAYPIG 2107 + DP A P AY+IYTSGSTGKPKG H + A + E + + Sbjct: 596 -----LDAEDPAPLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMR 650 Query: 2108 PGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLHFVP 2167 + L FD + PL+ GAR+ L A + + IR V L F P Sbjct: 651 AEDCELHFYSINFDAASERLLAPLLCGARVVLRAQGQW-GAEEICELIRAEGVSILGFTP 709 Query: 2168 SMLQAFVAHPDS-AQCHSLRQVICSGEALPAELQEQAFARLPQIALHNLYGPTEAAIDVT 2226 S +S + +R I GEAL E ++ + N YGPTE V Sbjct: 710 SYGSQLAQWLESQGRQLPVRMCITGGEALTGEHLQRIRQAFAPASFFNAYGPTETV--VM 767 Query: 2227 HWTCRPGER------SVPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGR 2280 C ER SVPIG + AY+LD L +P G GELY+GG GLARGY R Sbjct: 768 PLACLAPERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYHER 827 Query: 2281 PGLSAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQ 2340 P LSAERFV DPFAA+G R+YRTGDLVR +G++EY+GR DHQVKIRG RIELGEIEA+ Sbjct: 828 PALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIEAR 887 Query: 2341 LLAQPGVAAAVVVALVEPGRPARLVGYAA--------DPGGMLEAEALRAALLQSLPDYM 2392 LL P V A+V+AL P +L GY A D L EAL+ L Q LPDYM Sbjct: 888 LLEHPQVREALVLALDSPS-GKQLAGYVASAVAEQDEDAQAALR-EALKTHLKQQLPDYM 945 Query: 2393 VPQRLILLPALPLNANGKVDRKALPRPD--FNEQGGYEAPQGQTEIGLAAIWAEVLRLQR 2450 VP L+LL +LPL ANGK+DR+ALP PD N Q YEAP+ E LA +W EVL ++R Sbjct: 946 VPAHLLLLASLPLTANGKLDRRALPAPDPALNRQ-AYEAPRSVLEQQLAGVWREVLNVER 1004 Query: 2451 VGRHDNFFELGGDSILSLQIVARAHEQGWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQA 2510 VG DNFFELGGDSILS+Q+V+RA + G +PR LFQ QTV LA +QA Sbjct: 1005 VGLGDNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQSLAAVARH------SQA 1058 Query: 2511 VTAARGRLEDYLSAAQTAQLALQGELEDVYPLSPMQ---QGMLFHTMESPGSGLYVNQLS 2567 A +G ++ +A +Q D+ PL+ + Q +L ++ GL L Sbjct: 1059 SQAEQGPVQ-----GDSALTPIQHWFFDL-PLARREHWNQALLLQPRQAIDLGLLRKSLQ 1112 Query: 2568 VRVEGLDEAR--FAQAWQSVLARH-PVMRTGFLWQAGYAQPLQAVWRTLAFGIEVQDWSA 2624 VE D R F Q LA+H P+ LW P+Q+ Sbjct: 1113 RLVEQHDALRLAFRQVDGEWLAQHRPLREQELLWHV----PVQSF--------------- 1153 Query: 2625 RADDAELPQAIAAFAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWSTS 2684 + AEL FA A R DL Q PL+RA L+ G+ +L+ +HH+++DG S Sbjct: 1154 -DECAEL------FAKAQ--RSLDLEQGPLLRAVLVDGPAGEQRLLLAIHHLVVDGVSWR 1204 Query: 2685 ALMQELMLAY-----GGQP-LPAPGPDYAQYIGWLATLDPQAAQRYWMGALQA-LDGPSL 2737 L+++L Y G +P LPA + + G L + R +G QA L G + Sbjct: 1205 VLLEDLQQVYRQFAEGAEPALPAKTSAFRDWAGRLQAYAGSESLREELGWWQARLGGQPV 1264 Query: 2738 LAEGVRPDPARRG--FGKLYGHCDAAATRR-LEQFARSQRVTLNTLVQGAWSLALARHKR 2794 RP R + D TR+ L+Q + R +N L+ A + L R Sbjct: 1265 EWPCDRPQGDNREALAESVSLRLDPQRTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSG 1324 Query: 2795 STAVAFGATVSGRPAALPGVE--KSLGLFINTIPI 2827 + GR A ++ +S+G F + P+ Sbjct: 1325 QPSTLVQLEGHGREALFDDIDLTRSVGWFTSAYPL 1359 >PA2402_4 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1074 Score = 913 bits (2360), Expect = 0.0, Method: Compositional matrix adjust. Identities = 511/1055 (48%), Positives = 682/1055 (64%), Gaps = 24/1055 (2%) Query: 2535 ELEDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVRVEGLDEARFAQAWQSVLARHPVMRT 2594 E+ED+YPLSPMQQGMLFH++ S Y+NQ+ V V GLD RF AWQS L RH ++R+ Sbjct: 8 EVEDIYPLSPMQQGMLFHSLYEQASSDYINQMRVDVSGLDLPRFRAAWQSALDRHAILRS 67 Query: 2595 GFLWQAGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPL 2654 GF WQ QPLQ V+R +D S A+ A+ A AAA+ RGF+L + PL Sbjct: 68 GFAWQGELQQPLQIVYRQRQLPFAEEDLSQAANRD---AALLALAAAERERGFELQRAPL 124 Query: 2655 VRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGGQ-PLPAPGPDYAQYIGWL 2713 +R L++ G+H L++T HHILLDGWS + L+ E++ +Y G+ P Y+ YI WL Sbjct: 125 LRLLLVKTAEGEHHLIYTHHHILLDGWSNAQLLSEVLESYAGRSPEQLRDGRYSDYIAWL 184 Query: 2714 ATLDPQAAQRYWMGALQALDGPSLLAEGV-RPD-PARRGFGKLYGHCDAAATRRLEQFAR 2771 D A + +W + ALD P+ L E + +P + G G+ DA AT RL FAR Sbjct: 185 QRQDAAATEAFWREQMAALDEPTRLVEALAQPGLTSANGVGEHLREVDATATARLRDFAR 244 Query: 2772 SQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFINTIPIVVEV 2831 +VTLNTLVQ W+L L R+ V FGATVSGRPA LPGVE +GLFINT+P+VV + Sbjct: 245 RHQVTLNTLVQAGWALLLQRYTGQHTVVFGATVSGRPADLPGVENQVGLFINTLPVVVTL 304 Query: 2832 DGQRRVGDWLRTLQQTNIDSREHEHTPLYDIQRWSGMAGRALFDSIIVFENFPISRSLEA 2891 Q + + L+ LQ+ N+ RE EHTPL+++QRW+G G A+FD+++VFEN+P+ LE Sbjct: 305 APQMTLDELLQGLQRQNLALREQEHTPLFELQRWAGFGGEAVFDNLLVFENYPVDEVLER 364 Query: 2892 RAQAGLRFGQAEGEGLTGFAMDLQVVARETLDIEFCYDRSLFGDAELEALREQVMLNLDA 2951 + G+RFG T + + L + ++L ++F YDR LF A +E L + L+A Sbjct: 365 SSAGGVRFGAVAMHEQTNYPLALALGGGDSLSLQFSYDRGLFPAATIERLGRHLTTLLEA 424 Query: 2952 LSASGERALGELARLSPQALAAVLEL-GRGTHDYPADLPAHLLIARRAALTPDAIALVLE 3010 + +R L +L L L+A+ + R YPA H +A RA + PDA+A++ + Sbjct: 425 FAEHPQRRLVDLQMLEKAELSAIGAIWNRSDSGYPATPLVHQRVAERARMAPDAVAVIFD 484 Query: 3011 EQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMVVGLLAVMKAGAAYVPLDL 3070 E+ L+Y EL+ RANRLAH L++ GVG E RV +A++RS +++V LAV+KAG AYVPLD+ Sbjct: 485 EEKLTYAELDSRANRLAHALIARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDI 544 Query: 3071 DYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLALDDADLAAQLAGLPAHDPV 3130 +YP ERL YM+ DSR +LLTH+ L GL CL++D + + AG PAHDP Sbjct: 545 EYPRERLLYMMQDSRAHLLLTHSHLLERLPIPE--GLSCLSVDREE---EWAGFPAHDPE 599 Query: 3131 VAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALYEMTPQWRELQFMSFSFDG 3190 VA+ +AYVIYTSGSTG PKGVAVSHGPL+ H AT YEMTP+ EL FMSF+FDG Sbjct: 600 VALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDG 659 Query: 3191 AHERWITTLISGAALVLRGPEMWSIEQSWQALHQQRVSNAVFPPAYLGQLAQWGEQHGDA 3250 +HE W+ LI+GA +++R +W E+++ +H+ V+ VFPP YL QLA+ E+ G+ Sbjct: 660 SHEGWMHPLINGARVLIRDDSLWLPERTYAEMHRHGVTVGVFPPVYLQQLAEHAERDGNP 719 Query: 3251 PPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTETVVTPLIWKGTSAAGVDFDGPF 3310 PP+ +Y FGG+A+ +AS++ R L P+ L NGYGPTETVVTPL+WK + AG + Sbjct: 720 PPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVTPLLWK--ARAGDACGAAY 777 Query: 3311 VPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARGYLERPAQSAERFVADPFGEP 3370 +PIG +G R+ YILD L + G AGELY+GG+G+ARGYLERPA +AERFV DPFG P Sbjct: 778 MPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAP 837 Query: 3371 GARMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGEIEALLRRQPGVAEAAVVVRS 3430 G+R+YR+GDL R DG V+YLGR+DHQVKIRGFRIELGEIEA LR P V EA VV + Sbjct: 838 GSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLREHPSVREAVVVAQP 897 Query: 3431 DGQGEEAVRQLVAYV--GAPQAVAAPETAQRDFSDSLRAALRAGLPEYMLPAHFVLLAAL 3488 G+ QLV YV AP +PE AQ + L+ ALR LPEYM+P+H + LA + Sbjct: 898 GAVGQ----QLVGYVVAQAPAVADSPE-AQAECRAQLKTALRERLPEYMVPSHLLFLARM 952 Query: 3489 PVTHNGKLDRKALPAPQAAPARS-YVAPATPAAQALAEIWQTVLKRERVGQEDNFFELGG 3547 P+T NGKLDRK LP P A+ + YVAP + Q +A IW VL+ ++VG +DNFFELGG Sbjct: 953 PLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGG 1012 Query: 3548 DSLLCLQVIARARGQRQWNFNFKLADLMQRPTIAA 3582 SLL +QV AR Q + LA L Q ++ A Sbjct: 1013 HSLLAIQVTARM--QSEVGVELPLAALFQTESLQA 1045 Score = 820 bits (2117), Expect = 0.0, Method: Compositional matrix adjust. Identities = 505/1071 (47%), Positives = 645/1071 (60%), Gaps = 51/1071 (4%) Query: 1456 ALPLAARNVDDIYPLSPMQAGMLFHSVFEPGGSAYINQLRVDIDGLDAARFEQAWQDTVA 1515 ALP+A V+DIYPLSPMQ GMLFHS++E S YINQ+RVD+ GLD RF AWQ + Sbjct: 1 ALPVALEEVEDIYPLSPMQQGMLFHSLYEQASSDYINQMRVDVSGLDLPRFRAAWQSALD 60 Query: 1516 AHDILRTGFLHQ---PRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGF 1572 H ILR+GF Q +PLQ V R+ P ++ D + L ALA + +GF Sbjct: 61 RHAILRSGFAWQGELQQPLQIVYRQRQLPFAE---EDLSQAANRDAALLALAAAERERGF 117 Query: 1573 DLAAPPLMRLVLVRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTK 1632 +L PL+RL+LV+T HHLI+T HH+LLDGWS + LL EVL YA G++ Sbjct: 118 ELQRAPLLRLLLVKTAEGEHHLIYTHHHILLDGWSNAQLLSEVLESYA-----GRSPEQL 172 Query: 1633 LALRYRDYIGWLQGRDQEATRRFWEIQLARLQQPTRLADAMPRPS-TPQSGHGEHRELLD 1691 RY DYI WLQ +D AT FW Q+A L +PTRL +A+ +P T +G GEH +D Sbjct: 173 RDGRYSDYIAWLQRQDAAATEAFWREQMAALDEPTRLVEALAQPGLTSANGVGEHLREVD 232 Query: 1692 ATLTARLNEAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQ 1751 AT TARL + AR ++TLNTLVQA WALLLQRYT VVFGATV+GRPA+L GVE Sbjct: 233 ATATARLRDFARRHQVTLNTLVQAGWALLLQRYT---GQHTVVFGATVSGRPADLPGVEN 289 Query: 1752 LLGLFINTLPVIVATPPHQPAGDWMRALQAQNLQAREYEHTPLVDIQRWSGQGAQALFDS 1811 +GLFINTLPV+V P + ++ LQ QNL RE EHTPL ++QRW+G G +A+FD+ Sbjct: 290 QVGLFINTLPVVVTLAPQMTLDELLQGLQRQNLALREQEHTPLFELQRWAGFGGEAVFDN 349 Query: 1812 ILVFENYPVDATLSQGAPAGLAFSSVRHREETNYPMTVVVNAGDTLQLQLRYARAQFAHE 1871 +LVFENYPVD L + + G+ F +V E+TNYP+ + + GD+L LQ Y R F Sbjct: 350 LLVFENYPVDEVLERSSAGGVRFGAVAMHEQTNYPLALALGGGDSLSLQFSYDRGLFPAA 409 Query: 1872 MVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDELAA----WRESGVNRELHAFDAP--V 1925 +ER+G HL LL+ AEHPQ+ + L +L EL+A W NR + A V Sbjct: 410 TIERLGRHLTTLLEAFAEHPQRRLVDLQMLEKAELSAIGAIW-----NRSDSGYPATPLV 464 Query: 1926 HRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAPE 1985 H+ + +A P A A+++++ L Y L+ +ANRLAH L+A G GPE V +A +R+ E Sbjct: 465 HQRVAERARMAPDAVAVIFDEEKLTYAELDSRANRLAHALIARGVGPEVRVAIAMQRSAE 524 Query: 1986 MVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELTAPAAVRVLEL 2045 ++VA LAVLKAG AY+PLD + P RL MM DS LLLT + L L P + L + Sbjct: 525 IMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSV 584 Query: 2046 DAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAYP 2105 D + WA G P HDP + + D LAYVIYTSGSTG PKG H L + E Y Sbjct: 585 DRE-EEWA-GFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYE 642 Query: 2106 IGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLHF 2165 + P + L F FD S + PL+ GAR+ L D P A + RH V F Sbjct: 643 MTPEDCELHFMSFAFDGSHEGWMHPLINGARV-LIRDDSLWLPERTYAEMHRHGVTVGVF 701 Query: 2166 VPSMLQAFVAHPDSAQCHSLRQVIC-SGEALPAELQEQAFARLPQIALHNLYGPTEAAID 2224 P LQ H + +V C G+A+ + A+ L L N YGPTE + Sbjct: 702 PPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVT 761 Query: 2225 VTHWTCRPGERS----VPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGR 2280 W R G+ +PIG + + + Y+LDG LN LP G+AGELYLGG G+ARGYL R Sbjct: 762 PLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLER 821 Query: 2281 PGLSAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQ 2340 P L+AERFV DPF A GSR+YR+GDL R RADG ++YLGR DHQVKIRG RIELGEIEA+ Sbjct: 822 PALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEAR 881 Query: 2341 LLAQPGVAAAVVVALVEPGRPA-RLVGY--------AADPGGMLEAEA-LRAALLQSLPD 2390 L P V AVVVA +PG +LVGY A P E A L+ AL + LP+ Sbjct: 882 LREHPSVREAVVVA--QPGAVGQQLVGYVVAQAPAVADSPEAQAECRAQLKTALRERLPE 939 Query: 2391 YMVPQRLILLPALPLNANGKVDRKALPRPDFN-EQGGYEAPQGQTEIGLAAIWAEVLRLQ 2449 YMVP L+ L +PL NGK+DRK LP+PD + Q Y AP+ E +A IWAEVL+LQ Sbjct: 940 YMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQ 999 Query: 2450 RVGRHDNFFELGGDSILSLQIVARAH-EQGWPLTPRQLFQSQTV---AELA 2496 +VG DNFFELGG S+L++Q+ AR E G L LFQ++++ AELA Sbjct: 1000 QVGLDDNFFELGGHSLLAIQVTARMQSEVGVELPLAALFQTESLQAYAELA 1050 Score = 468 bits (1204), Expect = e-130, Method: Compositional matrix adjust. Identities = 356/988 (36%), Positives = 511/988 (51%), Gaps = 88/988 (8%) Query: 32 FDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDAWSNPLVIRDLAEAYR----QARRDGQ 87 F+L +A L + L+ EH L+ HHI+ D WSN ++ ++ E+Y + RDG+ Sbjct: 117 FELQRAPLLRLLLVKTAEGEHHLIYTHHHILLDGWSNAQLLSEVLESYAGRSPEQLRDGR 176 Query: 88 AQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLGPVNSSLDLPTDRPRPARQSFRG 147 Y+DY W +++ A A +W + + ++ L +P S G Sbjct: 177 ---------YSDYIAWLQRQDAAATEA----FWREQMAALDEPTRLVEALAQPGLTSANG 223 Query: 148 -AVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLLSRYSGQADFFF--FFAGR--N 202 H +D+ +++ F R T + A W +LL RY+GQ F +GR + Sbjct: 224 VGEHLREVDATATARLRDFARRHQVTLNTLVQAGWALLLQRYTGQHTVVFGATVSGRPAD 283 Query: 203 HAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAALEHGDLPF----------- 251 +++ VG F+ T L P++T+ EL++ ++ LA E P Sbjct: 284 LPGVENQVGLFINTLPVVVTLAPQMTLDELLQGLQRQNLALREQEHTPLFELQRWAGFGG 343 Query: 252 EALLEHRKVERDPGRNPLFQVMFGLQMVGEGASALAFDDIVTAPLPLAQDSAKFDLSLDV 311 EA+ ++ V + P+ +V+ G A+A + PL LA LSL Sbjct: 344 EAVFDNLLVFEN---YPVDEVLERSSAGGVRFGAVAMHEQTNYPLALALGGGD-SLSL-- 397 Query: 312 KVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALLDQDEQARLR 371 + Y LF AATI + H LL FA P+R + L +L++ E + + Sbjct: 398 ---------QFSYDRGLFPAATIERLGRHLTTLLEAFAEHPQRRLVDLQMLEKAELSAIG 448 Query: 372 S-WGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRAANRLAHRL 430 + W P TP + + +A PDAVAV+ ++++YA+L+ ANRLAH L Sbjct: 449 AIWNRSD--SGYPATP--LVHQRVAERARMAPDAVAVIFDEEKLTYAELDSRANRLAHAL 504 Query: 431 LQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQDAGVTLAL 490 + +GVGPE R+ +A RS E++V LA+LKAG AYVPLD +YP +RL YM+QD+ L L Sbjct: 505 IARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLL 564 Query: 491 TAGEGVSAL-TAQGLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGSTGRPKGAQ 549 T + L +GL L + PAH+P V LH DNLAY+IYTSGSTG PKG Sbjct: 565 THSHLLERLPIPEGLSCLSVDREEEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVA 624 Query: 550 LSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVVVPFAVSRS 609 +SH ++ + T ++ ED F S+AFD S L G R+++ ++ Sbjct: 625 VSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDDSLWL- 683 Query: 610 PEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEA-------LE 662 PE A + VTV P +QL + P +R FGG+A L Sbjct: 684 PERTYAEMHRHGVTVGVFPPVYLQQLAEHAERDGNPP---PVRVYCFGGDAVAQASYDLA 740 Query: 663 PEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRAD-LDASRSPIGAAIPDLGLYV 721 L+P L N YG TET V + D A+ PIG + + Y+ Sbjct: 741 WRALKP---------KYLFNGYGPTETVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYI 791 Query: 722 LDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLV 781 LD +LNL P GV GELY+ G G+ARGYL R AL+AERFV +PF G GSRLYR+GDL Sbjct: 792 LDGQLNLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPF---GAPGSRLYRSGDLT 848 Query: 782 RWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGYL 841 R R DG +DYLGR+D QVKIRGFRIELGEIEA+L P V A V+ + A +LVGY+ Sbjct: 849 RGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLREHPSVREAVVVAQPGAVGQQLVGYV 908 Query: 842 ---SPQAGIAPEALDT--GALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAP 896 +P +PEA L+TAL LP+YMVP+ L+ L +PL NGK+DRK LP P Sbjct: 909 VAQAPAVADSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQP 968 Query: 897 ELA-ARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRAR-RA 954 + + + Y AP+ LE+Q+A IW EVL+ VG DDNFFELGG S+L++Q+ +R + Sbjct: 969 DASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLAIQVTARMQSEV 1028 Query: 955 GIAITARQMFERQTV---AELAAVASEA 979 G+ + +F+ +++ AELAA + + Sbjct: 1029 GVELPLAALFQTESLQAYAELAAAQTSS 1056 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1317 Score = 848 bits (2191), Expect = 0.0, Method: Compositional matrix adjust. Identities = 550/1312 (41%), Positives = 748/1312 (57%), Gaps = 88/1312 (6%) Query: 2283 LSAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLL 2342 ++AERF+ DPF GSR+YRTGDL RRR DG IEY+GR DHQVKIRG RIELGE+EA+LL Sbjct: 1 MTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLL 60 Query: 2343 AQPGVAAAVVVALVEPGRPARLVGYAADPGGMLEA------EALRAALLQSLPDYMVPQR 2396 G+ A +AL +LV Y GG E E +R AL SLPDYMVP Sbjct: 61 DLEGIREAAALAL-----DGQLVAYLVAEGGEDETRQPALRERIRTALRASLPDYMVPSH 115 Query: 2397 LILLPALPLNANGKVDRKALPRPDFN-EQGGYEAPQGQTEIGLAAIWAEVLRLQRVGRHD 2455 L+ L +PL+ NGK+DR+ALP+PD Q + AP E +AAIW E+L ++RVG D Sbjct: 116 LLFLERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVGLTD 175 Query: 2456 NFFELGGDSILSLQIVARAHEQ-GWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQAVTAA 2514 NFFELGG S+L+ ++V+R + G ++ + LF+ + + + PA +T Sbjct: 176 NFFELGGHSLLATRLVSRIRQDLGIEVSLKSLFEQPVLQGFVESLGE--KPAEVPPITPV 233 Query: 2515 RGRLEDYLSAAQTAQLALQGELEDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-L 2573 E PLS Q+ F P S Y ++R+ G L Sbjct: 234 --------------------TREQPLPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGL 273 Query: 2574 DEARFAQAWQSVLARHPVMRTGFLWQAGYAQPLQAVWRTLAFG-IEVQDWS-ARADDAEL 2631 D ++++ + RH +RT F + L+ V A G ++V + A DDA L Sbjct: 274 DVVALQRSFERLAQRHESLRTRFRQEG-----LRTVQVVDADGQLQVSRHNLANVDDASL 328 Query: 2632 PQAIAAFAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELM 2691 A+ A ++AR FDL L+R +L + P H LV HHI+ DGWS +++EL+ Sbjct: 329 RAAVEA----EMARPFDLRTDALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELV 384 Query: 2692 LAYGGQP---------LPAPGPDYAQYI-GWLATLDPQAAQRYWMGALQALDGPSLLAEG 2741 Y LP PDYA + W+ + + YW+G L + P L Sbjct: 385 QLYAAYSQGREAALPALPIQYPDYAVWQREWMEAGERERQLAYWIGLLGG-EQPVLELPF 443 Query: 2742 VRPDPARRGF--GKLYGHCDAAATRRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAVA 2799 RP PA + F +L A RRL+ A+ Q + L+ ++ L R+ + + Sbjct: 444 DRPRPAEQSFRGARLEFELGAERARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDIR 503 Query: 2800 FGATVSGRPAALPGVEKSLGLFINTIPIVVEVDGQRRVGDWLRTLQQTNIDSREHEHTPL 2859 G V+ R E+ +G F+NT + ++DGQ L ++Q +++++ H+ P Sbjct: 504 VGVPVANRNRV--ETERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPF 561 Query: 2860 YDI----QRWSGMAGRALFDSIIVFENFPISRSLEARAQ-AGLRFGQAEGEGLTG-FAMD 2913 + Q ++ LF V N+ R + AGL + E T F + Sbjct: 562 EQLVEALQPERSLSHSPLFQ---VLFNYQAERGEHGLPEVAGLSIEEQAWESHTAQFDLV 618 Query: 2914 LQVVARETLDI--EFCYDRSLFGDAELEALREQVMLNLDALSASGERALGELARLSPQAL 2971 L E+ DI Y LF + E L LDA+ A + LGEL L + Sbjct: 619 LDTCESES-DIWAALVYATDLFDASTAERLVRHWQNLLDAILAMPDARLGELDMLDREER 677 Query: 2972 AAVLEL-GRGTHDYPADLPAHLLIARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHL 3030 + +L R YPA H +A RA + PDA+A++ +E+ L+Y EL+ RANRLAH L Sbjct: 678 EVIGQLWNRSDSGYPATPLVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHAL 737 Query: 3031 MSLGVGAEQRVGVAVERSFDMVVGLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLL 3090 ++ GVG E RV +A++RS +++V LAV+KAG AYVPLD++YP ERL YM+ DSR +LL Sbjct: 738 IARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLL 797 Query: 3091 THARARRLLAAQAQPGLRCLALDDADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQ 3150 TH+ L GL CL++D + + AG PAHDP VA+ +AYVIYTSGSTG Sbjct: 798 THSHLLERLPIPE--GLSCLSVDREE---EWAGFPAHDPEVALHGDNLAYVIYTSGSTGM 852 Query: 3151 PKGVAVSHGPLVMHCQATAALYEMTPQWRELQFMSFSFDGAHERWITTLISGAALVLRGP 3210 PKGVAVSHGPL+ H AT YEMTP+ EL FMSF+FDG+HE W+ LI+GA +++R Sbjct: 853 PKGVAVSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDD 912 Query: 3211 EMWSIEQSWQALHQQRVSNAVFPPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFER 3270 +W E+++ +H+ V+ VFPP YL QLA+ E+ G+ PP+ +Y FGG+A+ +AS++ Sbjct: 913 SLWLPERTYAEMHRHGVTVGVFPPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDL 972 Query: 3271 VRRHLAPRLLINGYGPTETVVTPLIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQ 3330 R L P+ L NGYGPTETVVTPL+WK + AG ++PIG +G R+ YILD L Sbjct: 973 AWRALKPKYLFNGYGPTETVVTPLLWK--ARAGDACGAAYMPIGTLLGNRSGYILDGQLN 1030 Query: 3331 PVAPGEAGELYIGGDGLARGYLERPAQSAERFVADPFGEPGARMYRTGDLARWLPDGNVE 3390 + G AGELY+GG+G+ARGYLERPA +AERFV DPFG PG+R+YR+GDL R DG V+ Sbjct: 1031 LLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVD 1090 Query: 3391 YLGRLDHQVKIRGFRIELGEIEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQ- 3449 YLGR+DHQVKIRGFRIELGEIEA LR P V EA VV + G+ QLV YV A + Sbjct: 1091 YLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVVAQPGAVGQ----QLVGYVVAQEP 1146 Query: 3450 AVAAPETAQRDFSDSLRAALRAGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPA 3509 AVA AQ + L+ ALR LPEYM+P+H + LA +P+T NGKLDRK LP P A+ Sbjct: 1147 AVADSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLL 1206 Query: 3510 RS-YVAPATPAAQALAEIWQTVLKRERVGQEDNFFELGGDSLLCLQVIARAR 3560 + YVAP + Q +A IW VL+ ++VG +DNFFELGG SLL QVI R R Sbjct: 1207 QQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLR 1258 Score = 616 bits (1588), Expect = e-175, Method: Compositional matrix adjust. Identities = 399/979 (40%), Positives = 550/979 (56%), Gaps = 27/979 (2%) Query: 20 LQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDAWSNPLVIRDLAEAY 79 L+ ++A A FDL L + L + P +HVLV+ HHIVSD WS L++ +L + Y Sbjct: 328 LRAAVEAEMARPFDLRTDALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLY 387 Query: 80 RQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLGPVNSSLDLPTDRPR 139 + +A LPALP+QY DYA WQR+ ++ +L YW LG L+LP DRPR Sbjct: 388 AAYSQGREAALPALPIQYPDYAVWQREWMEAGERERQLAYWIGLLGGEQPVLELPFDRPR 447 Query: 140 PARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLLSRYSGQADFFFF-- 197 PA QSFRGA F L + A++++A + Q + F+ L+A++Q LL RYSGQ+D Sbjct: 448 PAEQSFRGARLEFELGAERARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDIRVGVP 507 Query: 198 FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAALEHGDLPFEALLEH 257 A RN E + L+GFFV TQ+ +A + ++ L+ QVR L A H DLPFE L+E Sbjct: 508 VANRNRVETERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEA 567 Query: 258 RKVERDPGRNPLFQVMFGLQMVGEGASALAFDDIVTAPLPLAQDSAKFDLSLDVKVIKGE 317 + ER +PLFQV+F Q + +A+FDL LD + + Sbjct: 568 LQPERSLSHSPLFQVLFNYQAERGEHGLPEVAGLSIEEQAWESHTAQFDLVLDTCESESD 627 Query: 318 VHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALLDQDEQARL-RSWGDP 376 + L YA+DLFDA+T + H+QNLL A P+ + +L +LD++E+ + + W Sbjct: 628 IWAALVYATDLFDASTAERLVRHWQNLLDAILAMPDARLGELDMLDREEREVIGQLWNRS 687 Query: 377 QLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRAANRLAHRLLQQGVG 436 P TP + + +A PDAVAV+ ++++YA+L+ ANRLAH L+ +GVG Sbjct: 688 D--SGYPATP--LVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVG 743 Query: 437 PENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQDAGVTLALTAGEGV 496 PE R+ +A RS E++V LA+LKAG AYVPLD +YP +RL YM+QD+ L LT + Sbjct: 744 PEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLL 803 Query: 497 SAL-TAQGLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGSTGRPKGAQLSHANV 555 L +GL L + PAH+P V LH DNLAY+IYTSGSTG PKG +SH + Sbjct: 804 ERLPIPEGLSCLSVDREEEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPL 863 Query: 556 LRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVVVPFAVSRSPEDFLA 615 + + T ++ ED F S+AFD S L G R+++ ++ PE A Sbjct: 864 IAHIVATGERYEMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDDSLW-LPERTYA 922 Query: 616 LLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEALEPEMLRPWITQFGD 675 + VTV P +QL + P +R FGG+A+ + + Sbjct: 923 EMHRHGVTVGVFPPVYLQQLAEHAERDGNPP---PVRVYCFGGDAVAQA---SYDLAWRA 976 Query: 676 QRPA-LINMYGITETTVHVTYRRLLRAD-LDASRSPIGAAIPDLGLYVLDQRLNLAPAGV 733 +P L N YG TET V + D A+ PIG + + Y+LD +LNL P GV Sbjct: 977 LKPKYLFNGYGPTETVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGV 1036 Query: 734 PGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLVRWRHDGQMDYLG 793 GELY+ G G+ARGYL R AL+AERFV +PF G GSRLYR+GDL R R DG +DYLG Sbjct: 1037 AGELYLGGEGVARGYLERPALTAERFVPDPF---GAPGSRLYRSGDLTRGRADGVVDYLG 1093 Query: 794 RIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGYL---SPQAGIAPE 850 R+D QVKIRGFRIELGEIEA+L P V A V+ + A +LVGY+ P +PE Sbjct: 1094 RVDHQVKIRGFRIELGEIEARLREHPAVREAVVVAQPGAVGQQLVGYVVAQEPAVADSPE 1153 Query: 851 ALDT--GALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAPELA-ARTAYAAP 907 A L+TAL LP+YMVP+ L+ L +PL NGK+DRK LP P+ + + Y AP Sbjct: 1154 AQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVAP 1213 Query: 908 QGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRAR-RAGIAITARQMFER 966 + LE+Q+A IW EVL+ VG DDNFFELGG S+L+ Q++ R R R + + + MF Sbjct: 1214 RSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLRERLHLEVPIKSMFTA 1273 Query: 967 QTVAELAAVASEAVAAATP 985 +T+ E A + P Sbjct: 1274 ETLGEFCHGVETLKAESAP 1292 Score = 490 bits (1262), Expect = e-137, Method: Compositional matrix adjust. Identities = 393/1075 (36%), Positives = 547/1075 (50%), Gaps = 67/1075 (6%) Query: 1469 PLSPMQAGMLFHSVFEPGGSAYI--NQLRVDIDGLDAARFEQAWQDTVAAHDILRTGFLH 1526 PLS Q F EP +AY LR+ GLD +++++ H+ LRT F Sbjct: 240 PLSYAQERQWFLWQLEPESAAYHIPAALRLR-GGLDVVALQRSFERLAQRHESLRTRFRQ 298 Query: 1527 QP-RPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGFDLAAPPLMRLVLV 1585 + R +Q V QL L A + ++A+ FDL L+R+ L Sbjct: 299 EGLRTVQ-----VVDADGQLQVSRHNLANVDDASLRAAVEAEMARPFDLRTDALLRISLF 353 Query: 1586 RTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYRDYI---- 1641 H L+ HH++ DGWS +++ E+++ YA + +A L ++Y DY Sbjct: 354 EVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQYPDYAVWQR 413 Query: 1642 GWLQGRDQEATRRFWEIQLARLQQPT-RLADAMPRPSTPQSGHGEHREL-LDATLTARLN 1699 W++ ++E +W I L +QP L PRP+ QS G E L A RL Sbjct: 414 EWMEAGERERQLAYW-IGLLGGEQPVLELPFDRPRPAE-QSFRGARLEFELGAERARRLK 471 Query: 1700 EAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINT 1759 A+ Q + L+ A++ LL RY+ + + G VA R E+L+G F+NT Sbjct: 472 ALAQRQGASTFMLLLASFQALLYRYSGQSD---IRVGVPVANR--NRVETERLIGFFVNT 526 Query: 1760 LPVIVATPPHQPAGD-WMRALQAQNLQAREYEHTPLVDIQRWSGQGAQALFDSIL--VFE 1816 V+ A Q D + ++ ++L+A+ ++ P + + Q ++L S L V Sbjct: 527 -QVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVE-ALQPERSLSHSPLFQVLF 584 Query: 1817 NYPVDATLSQGAP--AGLAFSS---VRHREETNYPMTVVVNAGDTLQLQLRYARAQFAHE 1871 NY + G P AGL+ H + + + + D + L YA F Sbjct: 585 NYQAERG-EHGLPEVAGLSIEEQAWESHTAQFDLVLDTCESESD-IWAALVYATDLFDAS 642 Query: 1872 MVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDELAA----WRESGVNRELHAFDAP--V 1925 ER+ H ++LL + P +G L +L +E W NR + A V Sbjct: 643 TAERLVRHWQNLLDAILAMPDARLGELDMLDREEREVIGQLW-----NRSDSGYPATPLV 697 Query: 1926 HRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAPE 1985 H+ + +A P A A+++++ L Y L+ +ANRLAH L+A G GPE V +A +R+ E Sbjct: 698 HQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQRSAE 757 Query: 1986 MVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELTAPAAVRVLEL 2045 ++VA LAVLKAG AY+PLD + P RL MM DS LLLT + L L P + L + Sbjct: 758 IMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSV 817 Query: 2046 DAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAYP 2105 D + WA G P HDP + + D LAYVIYTSGSTG PKG H L + E Y Sbjct: 818 DRE-EEWA-GFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYE 875 Query: 2106 IGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLHF 2165 + P + L F FD S + PL+ GAR+ L D P A + RH V F Sbjct: 876 MTPEDCELHFMSFAFDGSHEGWMHPLINGARV-LIRDDSLWLPERTYAEMHRHGVTVGVF 934 Query: 2166 VPSMLQAFVAHPDSAQCHSLRQVIC-SGEALPAELQEQAFARLPQIALHNLYGPTEAAID 2224 P LQ H + +V C G+A+ + A+ L L N YGPTE + Sbjct: 935 PPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVT 994 Query: 2225 VTHWTCRPGERS----VPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGR 2280 W R G+ +PIG + + + Y+LDG LN LP G+AGELYLGG G+ARGYL R Sbjct: 995 PLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLER 1054 Query: 2281 PGLSAERFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQ 2340 P L+AERFV DPF A GSR+YR+GDL R RADG ++YLGR DHQVKIRG RIELGEIEA+ Sbjct: 1055 PALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEAR 1114 Query: 2341 LLAQPGVAAAVVVALVEPGRPA-RLVGY--------AADPGGMLEAEA-LRAALLQSLPD 2390 L P V AVVVA +PG +LVGY A P E A L+ AL + LP+ Sbjct: 1115 LREHPAVREAVVVA--QPGAVGQQLVGYVVAQEPAVADSPEAQAECRAQLKTALRERLPE 1172 Query: 2391 YMVPQRLILLPALPLNANGKVDRKALPRPDFN-EQGGYEAPQGQTEIGLAAIWAEVLRLQ 2449 YMVP L+ L +PL NGK+DRK LP+PD + Q Y AP+ E +A IWAEVL+LQ Sbjct: 1173 YMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQ 1232 Query: 2450 RVGRHDNFFELGGDSILSLQIVARAHEQGWPLTP-RQLFQSQTVAELAQQCDQLQ 2503 +VG DNFFELGG S+L+ Q++ R E+ P + +F ++T+ E + L+ Sbjct: 1233 QVGLDDNFFELGGHSLLATQVIGRLRERLHLEVPIKSMFTAETLGEFCHGVETLK 1287 Score = 225 bits (574), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 237/747 (31%), Positives = 343/747 (45%), Gaps = 78/747 (10%) Query: 754 LSAERFVANPFARAGEEGSRLYRTGDLVRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEA 813 ++AERF+ +PF GE GSRLYRTGDL R R DG ++Y+GR D QVKIRGFRIELGE+EA Sbjct: 1 MTAERFLPDPF---GEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEA 57 Query: 814 QLLAQPGVGAATVMVRQDAATPRLVGYLSPQAG---IAPEALDTGALRTALGAVLPDYMV 870 +LL G+ A + A +LV YL + G AL +RTAL A LPDYMV Sbjct: 58 RLLDLEGIREAAAL----ALDGQLVAYLVAEGGEDETRQPALRE-RIRTALRASLPDYMV 112 Query: 871 PAALVVLPALPLNINGKVDRKALPAPELA-ARTAYAAPQGALEEQLAAIWREVLKGGAVG 929 P+ L+ L +PL+ NGK+DR+ALP P+ + + AP ALE+ +AAIW E+L VG Sbjct: 113 PSHLLFLERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVG 172 Query: 930 RDDNFFELGGDSILSLQIVSRARRA-GIAITARQMFERQTVAELAAVASEAVAAATPRAI 988 DNFFELGG S+L+ ++VSR R+ GI ++ + +FE+ + E A P Sbjct: 173 LTDNFFELGGHSLLATRLVSRIRQDLGIEVSLKSLFEQPVLQGFVESLGEKPAEVPPITP 232 Query: 989 THTAQAGQACRLLPI-----QQDFFEADIPRRAHWNQSVLLHSDAPIDPAALAAALHALM 1043 Q LP+ +Q F P A ++ L +D AL + L Sbjct: 233 VTREQP------LPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQRSFERLA 286 Query: 1044 QAHPALTMRYAQHSDGWHQLHGELPTLQAIAERIVSARAADAEQLLALCESAQRSLDLEH 1103 Q H +L R+ Q +G + Q R A DA A+ R DL Sbjct: 287 QRHESLRTRFRQ--EGLRTVQVVDADGQLQVSRHNLANVDDASLRAAVEAEMARPFDLRT 344 Query: 1104 GLVLRAVLVDMGQAGWRLLLVAHHLVIDGVSWRVLLEDMQHAYA-----HACATPEQPLQ 1158 +LR L ++ L++V HH+V DG S ++++E++ YA A P P+Q Sbjct: 345 DALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQ 404 Query: 1159 LPAEEAGLAEWGEALAAYAPVAAQRIDHWLGLAGC--PV-QLPSDPARAGEEG-ASARLA 1214 P EW EA +++ +W+GL G PV +LP D R E+ ARL Sbjct: 405 YPDYAVWQREWMEAGE-----RERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGARLE 459 Query: 1215 -DQQSVLLRLTPALTQTLIGEAHSAWRTQVNDLLLAALARALAAWGAPQPLLVDLEGHGR 1273 + + R AL Q + S + LLLA+ L + + V + R Sbjct: 460 FELGAERARRLKALAQR---QGASTFM-----LLLASFQALLYRYSGQSDIRVGVPVANR 511 Query: 1274 EALGDGAATPDLSRTVGWFTSVFPLALEASG-TPLATLLRT--KESLRALPNKGLDFGVL 1330 + + R +G+F + L + G LL + SL A ++ L F L Sbjct: 512 NRV-------ETERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQL 564 Query: 1331 LRFGTAEQRDALQALPRAQVAFNYLGQFQSGEEGGWRLASESAGTPMDPHAAMRHA---- 1386 + E+ +L P QV FNY Q + GE G E AG ++ A H Sbjct: 565 VEALQPER--SLSHSPLFQVLFNY--QAERGEHG----LPEVAGLSIEEQAWESHTAQFD 616 Query: 1387 LTINGQVHEGVLQLRLNYCGKRYGRAMVETLAAHLQTQLEELAALCSQHAGGLTPSDLPL 1446 L ++ E + L Y + + E L H Q L+ + A+ G L D+ Sbjct: 617 LVLDTCESESDIWAALVYATDLFDASTAERLVRHWQNLLDAILAMPDARLGEL---DM-- 671 Query: 1447 AGLDQAQLDALPLAARNVDDIYPLSPM 1473 LD+ + + + D YP +P+ Sbjct: 672 --LDREEREVIGQLWNRSDSGYPATPL 696 >BS_ppsB_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Bsu Bacillus subtilis Length = 1510 Score = 839 bits (2167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 526/1480 (35%), Positives = 795/1480 (53%), Gaps = 91/1480 (6%) Query: 6 LDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDA 65 DL++L + EQ L+ ++ F L +I +G L++ MHHI++D Sbjct: 80 FDLKELE-MESEQMLESAIETFIK-PFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADG 137 Query: 66 WSNPLVIRDLAEAYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLG 125 S ++++ + Y +LPAL + Y D+A WQ+++ + YW LG Sbjct: 138 VSMSTLVQEFTDLY------CGKELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLG 191 Query: 126 PVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLL 185 +L+LP D+ RP FRG +D +A ++ T ++ L+A + +LL Sbjct: 192 GSLPTLELPLDKTRPRLPDFRGGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILL 251 Query: 186 SRYSGQADFFFFF--AGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAA 243 S+ SGQ D AGR HA+L+ ++G FV T R++ T + +R L A Sbjct: 252 SKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTA 311 Query: 244 LEHGDLPFEALLEHRKVERDPGRNPLFQVMFGLQMVGEGASALAFD--DIVTAPLPLAQD 301 EH D PFE L + R+ RNPLF M LQ + F+ + + + D Sbjct: 312 YEHQDYPFEELADKLDTNREVNRNPLFDAMLVLQ----SSEDFRFEVPGLSISSVTPKHD 367 Query: 302 SAKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLAL 361 +KFDL+L + + CR EY++ LF+ TI A ++ L++G A E ++ + L Sbjct: 368 ISKFDLTLHAEEHLSGIRCRFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQL 427 Query: 362 LDQDEQARLRSWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNR 421 L E+ L ++ + ++ L E Q A P+ +AVVCG Q++Y LN Sbjct: 428 LPAAERRLLLE----KMGQYAAYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNE 483 Query: 422 AANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMV 481 A R A L++QGV + +GL RS +MI+G+L+ILKAG AY+P+DP+YP +R+++M+ Sbjct: 484 KAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFML 543 Query: 482 QDAGVTLALTAGEGVSALTAQGLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGS 541 D+G L LT G++ L I +++ PA + D AY+IYTSG+ Sbjct: 544 NDSGAKLLLTE-RGLNKPADYTGHILYIDEC-ENNSIPADVNIEEIVTDQPAYVIYTSGT 601 Query: 542 TGRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVV 601 TG+PKG + H NV+ LL F+F EDVWTLFHSY FDFSVWE+FGAL G LVV Sbjct: 602 TGQPKGVIVEHRNVISLLKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVV 661 Query: 602 VPFAVSRSPEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEAL 661 V +R P+ F LL ++RVTVLNQTP+AF L+ Q ++ L +R VIFGGEAL Sbjct: 662 VSKETARDPQAFRLLLKKERVTVLNQTPTAFYGLM---LEDQNHTDHLNIRYVIFGGEAL 718 Query: 662 EPEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRADLDASRSPIGAAIPDLGLYV 721 +P +L+ W ++ LINMYGITETTVHVT+++L AD+ ++S IG + L +V Sbjct: 719 QPGLLQSWNEKY--PHTDLINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHV 776 Query: 722 LDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLV 781 +D +NL P GVPGELY+ G G+ARGYLNR L+A+RFV+NP+ G RLYRTGDL Sbjct: 777 MDAHMNLQPTGVPGELYIGGEGVARGYLNRDELTADRFVSNPYL----PGDRLYRTGDLA 832 Query: 782 RWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDA-ATPRLVGY 840 + +G+++YLGRID+QVK+RG RIELGEI+A LL P + A V+ R D + Y Sbjct: 833 KRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAY 892 Query: 841 LSPQAGIAPEALDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAPELAA 900 + + +A + +RT L LPD+M+PA ++ + ++P+ +NGK+D+KALP PE A Sbjct: 893 MVIK---DQQAANISDIRTYLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQA 949 Query: 901 RTA-YAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRARRAGIAIT 959 TA +P+ +E +A IW E+L +G NFF+LGGDSI +LQ+ +R ++ G T Sbjct: 950 YTADDISPRNEIETVMAEIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETT 1009 Query: 960 ARQMFERQTVAELAAVASEAVAAATPRAITHTAQAGQACRLLPIQQDFFEADIPRRAHWN 1019 R+MFE QT+ EL+A + V RAI G+ PIQQ FF + H+N Sbjct: 1010 VREMFEHQTLGELSARVRKDV-----RAIDQGPVEGEIT-WTPIQQWFFSQSLESH-HFN 1062 Query: 1020 QSVLLHSDAPIDPAALAAALHALMQAHPALTMRYAQHSDGWH-QLHG--ELPTLQAIAER 1076 QSV+++ D AAL L +L+ H AL + +H DG Q++ +L + A Sbjct: 1063 QSVMIYRAERFDEAALRKVLKSLVTHHDALRI-VCRHEDGRQVQINRGIDLSDEELYALE 1121 Query: 1077 IVSARAADAEQLLALCESAQR---SLDLEHGLVLRAVLVDMGQAGWRLLLVAHHLVIDGV 1133 + + + E + E+A R + LE G +L A L + G L L HHLV+D V Sbjct: 1122 LFDVKDSLTEARNTIEEAASRMQEHIRLETGPLLHAGLF-RTENGDHLFLTIHHLVVDAV 1180 Query: 1134 SWRVLLEDMQHAYAHACATPEQPLQLPAEEAGLAEWGEALAAYAPV--AAQRIDHWLGLA 1191 SWR+L ED AY A + + ++LP + + + +A Y+ + +W Sbjct: 1181 SWRILFEDFSTAYKQAVSG--ESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECE 1238 Query: 1192 GCPVQ-LPSDPARAGEEGASARLADQQSVLLRLTPALTQTLIGEAHSAWRTQVNDLLLAA 1250 +Q +P D + AS D + + L+ T+ L+ AH A+ T++ND+LL A Sbjct: 1239 NRHIQPIPKD-----NDAASNTFKDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTA 1293 Query: 1251 LARALAAWGAPQPLLVDLEGHGREALGDGAATPDLSRTVGWFTSVFPLALEASGTP---- 1306 L AL W + +EGHGRE+ + D+SRTVGWFTS++P+ L+ + Sbjct: 1294 LGLALQKWTGNNQFKISMEGHGRESYLEDI---DISRTVGWFTSIYPVWLDMRDSDHKDK 1350 Query: 1307 ---LATLLR-TKESLRALPNKGLDFGVL----LRFGTAEQRDALQALPRAQVAFNYLGQF 1358 L L++ TK+ L +P+KG +GVL R+G+ Q+++ +++FNYLGQF Sbjct: 1351 EERLGHLIKQTKDMLHRIPHKGAGYGVLKYISKRWGS--QKNS------PEISFNYLGQF 1402 Query: 1359 -QSGEEGGWRLASESAGTPMDPHAAMRHALTINGQVHEGVLQLRLNYCGKRYGRAMVETL 1417 Q + + ++ G + P+ +AL I+G V G L + + Y ++ ++T Sbjct: 1403 DQDIQSNAFEVSDIKPGNEISPNWERPYALDISGAVSSGCLNMHIIYNRFQFEEKTIQTF 1462 Query: 1418 AAHLQTQLEELAALCSQH------AGGLTPSDLPLAGLDQ 1451 + H + LE + C+ A T DL L L + Sbjct: 1463 SRHFKQTLENIIEHCTGKENQEWSASDFTDEDLTLDELSE 1502 Score = 481 bits (1239), Expect = e-134, Method: Compositional matrix adjust. Identities = 403/1432 (28%), Positives = 658/1432 (45%), Gaps = 131/1432 (9%) Query: 1466 DIYPLSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGF 1524 D+YPLS Q + + Y +++ G L+ R + V H+ LRT F Sbjct: 4 DVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGNLNRQRLRSVLTELVNRHEALRTVF 63 Query: 1525 -LHQPRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGFDLAAPPLMRLV 1583 L + P+Q + +A L +L+ + Q L ++ + F L++ PL R Sbjct: 64 VLDRDEPVQIIYPEMAFDLKELEME---SEQMLESAIETFIK-----PFYLSSGPLFRAC 115 Query: 1584 LVRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYRDYIGW 1643 ++ G R L+ +HH++ DG S S L+ E Y G+ P L L Y+D+ W Sbjct: 116 VITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYC-----GKELPA-LNLHYKDFAVW 169 Query: 1644 LQGRD-QEATRR---FWEIQLARLQQPTRLADAMPRPSTPQSGHGEHRELLDATLTARLN 1699 Q + +E ++ +W QL L RP P G +D + L+ Sbjct: 170 QQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFRGGTIEVNIDKDMADELH 229 Query: 1700 EAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINT 1759 TL ++ A +++LL + + + +V G+ AGRP +E+++G+F+NT Sbjct: 230 RLMAETGTTLYMILLAVYSILLSK---LSGQEDIVVGSPAAGRPH--ADLERVIGMFVNT 284 Query: 1760 LPVIVATPPHQPAGDWMRALQAQNLQAREYEHTPL------VDIQRWSGQGAQALFDSIL 1813 L + H+ ++ ++ L A E++ P +D R + LFD++L Sbjct: 285 LAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDTNREVNRNP--LFDAML 342 Query: 1814 VFENYPVDATLSQGAPAGLAFSSVRHREETNYPMTVVVNAGDTL---QLQLRYARAQFAH 1870 V ++ P GL+ SSV + + + + ++A + L + + Y+ A F Sbjct: 343 VLQS---SEDFRFEVP-GLSISSVTPKHDIS-KFDLTLHAEEHLSGIRCRFEYSTALFEE 397 Query: 1871 EMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDELAAWRESGVNRELHAFDAPVHRLIE 1930 E + + ++ L++ + + I ++ LLP E E + + + L E Sbjct: 398 ETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYAAYPRNENIVSLFE 457 Query: 1931 RQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAPEMVVAL 1990 +Q A P A++ L YR LN++A R A L+ +G IVG+ R+P+M++ + Sbjct: 458 KQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGV 517 Query: 1991 LAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELTAPAAVRVLELDAPGQ 2050 L++LKAG AYLP+DP+ P R++ M+ DSG LLLT+ L A +L +D + Sbjct: 518 LSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNK--PADYTGHILYID---E 572 Query: 2051 PWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAYPIGPGN 2110 +P E+ D AYVIYTSG+TG+PKG H ++ + L + + Sbjct: 573 CENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISLLKHQNLPFEFNHED 632 Query: 2111 TVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLHFVPSML 2170 + FD SVWE F L+ G+ L + + + RDP +++ V L+ P+ Sbjct: 633 VWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLLLKKERVTVLNQTPTAF 692 Query: 2171 QAFVAHPDSAQCH-SLRQVICSGEALPAELQEQAFARLPQIALHNLYGPTEAAIDVTHWT 2229 + + H ++R VI GEAL L + + P L N+YG TE + VT Sbjct: 693 YGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTDLINMYGITETTVHVTFKK 752 Query: 2230 CRPGE---RSVPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGRPGLSAE 2286 + IGRP+S A+V+D +N P G+ GELY+GG G+ARGYL R L+A+ Sbjct: 753 LSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGELYIGGEGVARGYLNRDELTAD 812 Query: 2287 RFVADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLLAQPG 2346 RFV++P+ G R+YRTGDL +R ++GE+EYLGR D QVK+RG RIELGEI+A LL P Sbjct: 813 RFVSNPYLP-GDRLYRTGDLAKRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQYPM 871 Query: 2347 VA-AAVVVALVEPGRPARLVGYAADPGGMLEAEALRAALLQSLPDYMVPQRLILLPALPL 2405 + AAV+ E G+ A +R L +LPD+M+P R+I + ++P+ Sbjct: 872 IKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRTYLKNALPDFMLPARMIQIDSIPV 931 Query: 2406 NANGKVDRKALPRPDFNEQGGYEA----PQGQTEIGLAAIWAEVLRLQRVGRHDNFFELG 2461 NGK+D+KALP P E+ Y A P+ + E +A IW E+L + +G NFF+LG Sbjct: 932 TVNGKLDQKALPEP---EKQAYTADDISPRNEIETVMAEIWEELLNVDELGVSANFFKLG 988 Query: 2462 GDSILSLQIVARAHEQGWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQAVTAARGRLEDY 2521 GDSI +LQ+ AR ++G+ T R++F+ QT+ EL+ AR R Sbjct: 989 GDSIKALQVCARLKQRGFETTVREMFEHQTLGELS-----------------ARVR---- 1027 Query: 2522 LSAAQTAQLALQGELEDVYPLSPMQQGMLFHTMESPGSGLYVNQ--LSVRVEGLDEARFA 2579 + + QG +E +P+QQ ++ES + NQ + R E DEA Sbjct: 1028 ----KDVRAIDQGPVEGEITWTPIQQWFFSQSLESH----HFNQSVMIYRAERFDEAALR 1079 Query: 2580 QAWQSVLARHPVMRTGFLWQAGYAQPLQAVWRTLAFGIEVQDWSARA-------DDAELP 2632 + +S++ H +R + G + GI++ D A D Sbjct: 1080 KVLKSLVTHHDALRIVCRHEDGRQVQINR-------GIDLSDEELYALELFDVKDSLTEA 1132 Query: 2633 QAIAAFAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELML 2692 + AA+ + L PL+ A L R G H L T+HH+++D S L ++ Sbjct: 1133 RNTIEEAASRMQEHIRLETGPLLHAGLFRTENGDH-LFLTIHHLVVDAVSWRILFEDFST 1191 Query: 2693 AY----GGQ--PLPAPGPDYAQYIGWLATLD-PQAAQR---YWMGA----LQALDGPSLL 2738 AY G+ LP Y Y +A + QR YW +Q + + Sbjct: 1192 AYKQAVSGESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDA 1251 Query: 2739 AEGVRPDPARRGFGKLYGHCDAAATRRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAV 2798 A D F H + T + ++ +N ++ A LAL + + Sbjct: 1252 ASNTFKDTEVIDFELSRHHTELLLTAAHKAYS----TEMNDILLTALGLALQKWTGNNQF 1307 Query: 2799 AFGATVSGRPAALPGVE--KSLGLFINTIPIVVEV------DGQRRVGDWLR 2842 GR + L ++ +++G F + P+ +++ D + R+G ++ Sbjct: 1308 KISMEGHGRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIK 1359 Score = 450 bits (1157), Expect = e-125, Method: Compositional matrix adjust. Identities = 333/1066 (31%), Positives = 537/1066 (50%), Gaps = 67/1066 (6%) Query: 2538 DVYPLSPMQQGML-FHTMESPGSGLYVNQLSVRVEGLDEARFAQAWQSVLARHPVMRTGF 2596 DVYPLS Q+ + H + +G + + L+ R ++ RH +RT F Sbjct: 4 DVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGNLNRQRLRSVLTELVNRHEALRTVF 63 Query: 2597 LWQAGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPLVR 2656 + +P+Q ++ +AF ++ + + + L AI F + F L PL R Sbjct: 64 VLDRD--EPVQIIYPEMAFDLKELEMES---EQMLESAIETFI-----KPFYLSSGPLFR 113 Query: 2657 ATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGGQPLPAPGPDYAQYIGWLATL 2716 A ++ +G + L+ MHHI+ DG S S L+QE Y G+ LPA Y + W Sbjct: 114 ACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFAVWQQEK 173 Query: 2717 DPQAAQR----YWMGALQ-ALDGPSLLAEGVRPD-PARRGFGKLYGHCDAAATRRLEQFA 2770 P+ + YW+G L +L L + RP P RG G + + D L + Sbjct: 174 HPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFRG-GTIEVNIDKDMADELHRLM 232 Query: 2771 RSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFINTIPIVVE 2830 TL ++ +S+ L++ + G+ +GRP A +E+ +G+F+NT+ + + Sbjct: 233 AETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHA--DLERVIGMFVNTLAMRSK 290 Query: 2831 VDGQRRVGDWLRTLQQTNIDSREHEHTPLYDI----QRWSGMAGRALFDSIIVFENFPIS 2886 +G + +L ++ + + EH+ P ++ + LFD+++V ++ Sbjct: 291 PEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDTNREVNRNPLFDAMLVLQS---- 346 Query: 2887 RSLEARAQA-GLRFGQAE-GEGLTGFAMDLQVVARETLD---IEFCYDRSLFGDAELEAL 2941 S + R + GL ++ F DL + A E L F Y +LF + + Sbjct: 347 -SEDFRFEVPGLSISSVTPKHDISKF--DLTLHAEEHLSGIRCRFEYSTALFEEETITQW 403 Query: 2942 REQVMLNLDALSASGERALGELARLSPQALAAVLELGRGTHDYPADLPAHLLIARRAALT 3001 + + ++A E + + L +LE YP + L ++ A Sbjct: 404 ASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYAAYPRNENIVSLFEKQVAQY 463 Query: 3002 PDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMVVGLLAVMKA 3061 P+ IA+V L+Y +LN +A R A L+ GV VG+ ++RS DM++G+L+++KA Sbjct: 464 PEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGVLSILKA 523 Query: 3062 GAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLALDDADLAAQL 3121 G AY+P+D +YP ER+++M+ DS ++LLT R L A L +D+ + + Sbjct: 524 GGAYLPIDPEYPKERISFMLNDSGAKLLLT----ERGLNKPADYTGHILYIDECENNS-- 577 Query: 3122 AGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALYEMTPQWREL 3181 +PA + + Q AYVIYTSG+TGQPKGV V H ++ + +E + Sbjct: 578 --IPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISLLKHQNLPFEFNHEDVWT 635 Query: 3182 QFMSFSFDGAHERWITTLISGAALVLRGPEMWSIEQSWQAL-HQQRVS--NAVFPPAYLG 3238 F S+ FD + L++G+ LV+ E Q+++ L ++RV+ N P A+ G Sbjct: 636 LFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLLLKKERVTVLNQT-PTAFYG 694 Query: 3239 QLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTETVVTPLIWKG 3298 + + + H D + +FGGEA+ + LIN YG TET V + +K Sbjct: 695 LMLE-DQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTDLINMYGITETTV-HVTFKK 752 Query: 3299 TSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGDGLARGYLERPAQS 3358 SAA + + IG+P+ A+++DA + G GELYIGG+G+ARGYL R + Sbjct: 753 LSAADIAKNKS--NIGRPLSTLQAHVMDAHMNLQPTGVPGELYIGGEGVARGYLNRDELT 810 Query: 3359 AERFVADPFGEPGARMYRTGDLARWLPDGNVEYLGRLDHQVKIRGFRIELGEIEALLRRQ 3418 A+RFV++P+ PG R+YRTGDLA+ L +G +EYLGR+D QVK+RG RIELGEI+A L + Sbjct: 811 ADRFVSNPYL-PGDRLYRTGDLAKRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQY 869 Query: 3419 PGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQRDFSDSLRAALRAGLPEYML 3478 P + EAAV+ R+D QG+ A+ AY+ AA + SD +R L+ LP++ML Sbjct: 870 PMIKEAAVITRADEQGQTAI---YAYMVIKDQQAA------NISD-IRTYLKNALPDFML 919 Query: 3479 PAHFVLLAALPVTHNGKLDRKALPAPQA-APARSYVAPATPAAQALAEIWQTVLKRERVG 3537 PA + + ++PVT NGKLD+KALP P+ A ++P +AEIW+ +L + +G Sbjct: 920 PARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMAEIWEELLNVDELG 979 Query: 3538 QEDNFFELGGDSLLCLQVIARARGQRQWNFNFKLADLMQRPTIAAL 3583 NFF+LGGDS+ LQV AR +Q F + ++ + T+ L Sbjct: 980 VSANFFKLGGDSIKALQVCARL---KQRGFETTVREMFEHQTLGEL 1022 >PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1105 Score = 831 bits (2146), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/975 (48%), Positives = 612/975 (62%), Gaps = 15/975 (1%) Query: 6 LDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDA 65 LD+ L P + E L +++ A FDL + L V L+ L +HVLV+ HHIVSD Sbjct: 121 LDIVALGPLE-EGALARQVETTIARPFDLERGPLLRVSLLRLAEDDHVLVLVQHHIVSDG 179 Query: 66 WSNPLVIRDLAEAYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLG 125 WS +++ +L + Y R + LPALP+QYADYA WQR ++ +L YW LG Sbjct: 180 WSMQVMVEELVQLYAAYSRGLEVALPALPIQYADYALWQRSWMEAGEKERQLAYWTGLLG 239 Query: 126 PVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLL 185 L+LP DRPRP RQS RGA LD L+Q ++ + + T F L+A++Q LL Sbjct: 240 GEQPVLELPFDRPRPVRQSHRGAQFILELDIDLSQALRRVAQQEGATAFALLLASFQALL 299 Query: 186 SRYSGQADFFFF--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAA 243 RYSGQAD A RN E + L+GFFV TQ+ +A L + EL+ Q R L A Sbjct: 300 YRYSGQADIRVGVPIANRNRVETERLIGFFVNTQVLKADLDGRMGFDELLAQARQRALEA 359 Query: 244 LEHGDLPFEALLEHRKVERDPGRNPLFQVMFGLQMVGEG-ASALAFDDIVTAPLPLAQDS 302 H DLPFE L+E + ER NPLFQV+F Q G A FD++ + + Sbjct: 360 QAHQDLPFEQLVEALQPERSLSHNPLFQVLFNYQSEARGNGQAFRFDELQMESVQFDSRT 419 Query: 303 AKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALL 362 A+FDL+LD+ + +YA+DLFDA+T+ +AGH++NLLRG A P + + +L LL Sbjct: 420 AQFDLTLDLTDEEQRFCAVFDYATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLL 479 Query: 363 DQDEQARLRSWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRA 422 D E+ + S +P RE +L E QA P AVA++ Q++SY +LN Sbjct: 480 DAPERRQTLSEWNPAQREC---AVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNAR 536 Query: 423 ANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQ 482 ANRLAH L+ +GVG + +GLA RSL+M+VGLLAILKAG AY+PLDP P +RLA+++ Sbjct: 537 ANRLAHCLIARGVGADVPVGLALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILD 596 Query: 483 DAGVTLALTAGEGVSALTAQ-GLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGS 541 D+GV L LT G + L Q G+ L I L D +P L DNLAY+IYTSGS Sbjct: 597 DSGVRLLLTQGHLLERLPRQAGVEVLAI-DGLVLDGYAESDPLPTLSADNLAYVIYTSGS 655 Query: 542 TGRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVV 601 TG+PKG L+H N LRL T AWF F DVWTLFHSYAFDFSVWEIFGAL YGG LV+ Sbjct: 656 TGKPKGTLLTHRNALRLFSATEAWFGFDERDVWTLFHSYAFDFSVWEIFGALLYGGCLVI 715 Query: 602 VPFAVSRSPEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEAL 661 VP VSRSPEDF LL + VTVLNQTPSAF+QL+ + + ++ ALR VIFGGEAL Sbjct: 716 VPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEAL 775 Query: 662 EPEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRADLDASR-SPIGAAIPDLGLY 720 + + LRPW +FGD++P L+NMYGITETTVHVTYR + ADL+ SPIG IPDL Y Sbjct: 776 DLQSLRPWFQRFGDRQPQLVNMYGITETTVHVTYRPVSEADLEGGLVSPIGGTIPDLSWY 835 Query: 721 VLDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDL 780 +LD+ LN P G GELY+ AGLARGYL R LSA RFV NPF G G RLYRTGDL Sbjct: 836 ILDRDLNPVPRGAVGELYIGRAGLARGYLRRPGLSATRFVPNPF--PGGAGERLYRTGDL 893 Query: 781 VRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGY 840 R++ DG ++Y+GRID QVK+RGFRIELGEIEA L GV A V+ +LVGY Sbjct: 894 ARFQADGNIEYIGRIDHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVGGTQLVGY 953 Query: 841 LSPQAGIAPEALDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAPELA- 899 + + E L +LR +L LPDYMVPA L++L +PL +NGK+DR+ALP P+ + Sbjct: 954 VVADSAEDAERLRE-SLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASL 1012 Query: 900 ARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSRARRA-GIAI 958 ++ AY AP LE+++AAIW E+L VG DDNFFELGG S+L+ +++SR R+ + Sbjct: 1013 SQQAYRAPGSELEQRIAAIWSEILGVERVGLDDNFFELGGHSLLATRVISRVRQEQQLDA 1072 Query: 959 TARQMFERQTVAELA 973 + + +FER + A Sbjct: 1073 SLKALFERPVLEAFA 1087 Score = 491 bits (1263), Expect = e-137, Method: Compositional matrix adjust. Identities = 388/1090 (35%), Positives = 557/1090 (51%), Gaps = 89/1090 (8%) Query: 2542 LSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTGFLWQA 2600 LS Q+ F P S Y +R+ G LD +++ S++ARH +RT F Sbjct: 47 LSYAQERQWFLWQLEPESAAYHIPSVLRLRGRLDLDALQRSFDSLVARHETLRTRFRLDG 106 Query: 2601 GYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPLVRATLL 2660 A+ Q + ++A +++ + A +A +AR FDL + PL+R +LL Sbjct: 107 DEAR--QEIAASMALPLDIVALGPLEEGA-----LARQVETTIARPFDLERGPLLRVSLL 159 Query: 2661 RLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGGQP------LPAPGPDYAQYI---- 2710 RL H LV HHI+ DGWS +++EL+ Y LPA YA Y Sbjct: 160 RLAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSRGLEVALPALPIQYADYALWQR 219 Query: 2711 GWLATLDPQAAQRYWMGALQALDGPSLLAEGVRPDPARRGF--GKLYGHCDAAATRRLEQ 2768 W+ + + YW G L + P L RP P R+ + D ++ L + Sbjct: 220 SWMEAGEKERQLAYWTGLLGG-EQPVLELPFDRPRPVRQSHRGAQFILELDIDLSQALRR 278 Query: 2769 FARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFINTIPIV 2828 A+ + T L+ ++ L R+ + G ++ R E+ +G F+NT + Sbjct: 279 VAQQEGATAFALLLASFQALLYRYSGQADIRVGVPIANRNRV--ETERLIGFFVNTQVLK 336 Query: 2829 VEVDGQRRVGDWLRTLQQTNIDSREHEHTPLYDI----QRWSGMAGRALFDSIIVFENFP 2884 ++DG+ + L +Q ++++ H+ P + Q ++ LF + +++ Sbjct: 337 ADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERSLSHNPLFQVLFNYQS-- 394 Query: 2885 ISRSLEARAQA-GLRFGQAEGEGL------TGFAMDLQVVARETLDIEFC----YDRSLF 2933 EAR RF + + E + F + L + E FC Y LF Sbjct: 395 -----EARGNGQAFRFDELQMESVQFDSRTAQFDLTLDLTDEEQ---RFCAVFDYATDLF 446 Query: 2934 GDAELEALREQVMLNLDALSASGERALGELARL-SPQALAAVLELGRGTHDYPADLPAHL 2992 + +E L L + A+ + LGEL L +P+ + E + Sbjct: 447 DASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSEWNPAQRECAVQGTLQQ 506 Query: 2993 LIARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMV 3052 +A P A+AL+L+EQ LSYGELN RANRLAH L++ GVGA+ VG+A+ERS DM+ Sbjct: 507 RFEEQARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDML 566 Query: 3053 VGLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLAL 3112 VGLLA++KAG AY+PLD P ERLA+++ DS +++LLT L QA G+ LA+ Sbjct: 567 VGLLAILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQA--GVEVLAI 624 Query: 3113 DDADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALY 3172 D L G DP+ ++ +AYVIYTSGSTG+PKG ++H + AT A + Sbjct: 625 D----GLVLDGYAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWF 680 Query: 3173 EMTPQWRELQFMSFSFDGAHERWITTLISGAALVL------RGPEMWSIEQSWQALHQQR 3226 + F S++FD + L+ G LV+ R PE + ++ L ++ Sbjct: 681 GFDERDVWTLFHSYAFDFSVWEIFGALLYGGCLVIVPQWVSRSPEDF-----YRLLCREG 735 Query: 3227 VSNAVFPPAYLGQL---AQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPR--LLI 3281 V+ P+ QL A + P L +FGGEA+ S + R L+ Sbjct: 736 VTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQPQLV 795 Query: 3282 NGYGPTETVVTPLIWKGTSAAGVDFDGPFV-PIGKPVGRRNAYILDACLQPVAPGEAGEL 3340 N YG TET V + ++ S A D +G V PIG + + YILD L PV G GEL Sbjct: 796 NMYGITETTVH-VTYRPVSEA--DLEGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGEL 852 Query: 3341 YIGGDGLARGYLERPAQSAERFVADPF-GEPGARMYRTGDLARWLPDGNVEYLGRLDHQV 3399 YIG GLARGYL RP SA RFV +PF G G R+YRTGDLAR+ DGN+EY+GR+DHQV Sbjct: 853 YIGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQV 912 Query: 3400 KIRGFRIELGEIEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQR 3459 K+RGFRIELGEIEA L GV + AVV+ DG G QLV YV A A E A+R Sbjct: 913 KVRGFRIELGEIEAALAGLAGVRD-AVVLAHDGVGGT---QLVGYVVADSA----EDAER 964 Query: 3460 DFSDSLRAALRAGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPA-RSYVAPATP 3518 +SLR +L+ LP+YM+PAH +LL +P+T NGKLDR+ALP P A+ + ++Y AP + Sbjct: 965 -LRESLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSE 1023 Query: 3519 AAQALAEIWQTVLKRERVGQEDNFFELGGDSLLCLQVIARARGQRQWNFNFKLADLMQRP 3578 Q +A IW +L ERVG +DNFFELGG SLL +VI+R R ++Q + + K L +RP Sbjct: 1024 LEQRIAAIWSEILGVERVGLDDNFFELGGHSLLATRVISRVRQEQQLDASLKA--LFERP 1081 Query: 3579 TIAALL-GLE 3587 + A GLE Sbjct: 1082 VLEAFAQGLE 1091 Score = 489 bits (1260), Expect = e-137, Method: Compositional matrix adjust. Identities = 402/1097 (36%), Positives = 545/1097 (49%), Gaps = 100/1097 (9%) Query: 1458 PLAARNVDDIYPLSPMQAGMLFHSVFEPGGSAY----INQLRVDIDGLDAARFEQAWQDT 1513 P+ R + LS Q F EP +AY + +LR +D LDA ++++ Sbjct: 35 PVFKRQDGEPLRLSYAQERQWFLWQLEPESAAYHIPSVLRLRGRLD-LDA--LQRSFDSL 91 Query: 1514 VAAHDILRTGF-LHQPRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGF 1572 VA H+ LRT F L Q +A +A PL + A G G L + +A+ F Sbjct: 92 VARHETLRTRFRLDGDEARQEIAASMALPLDIV-----ALGPLEEGALARQVETTIARPF 146 Query: 1573 DLAAPPLMRLVLVRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTK 1632 DL PL+R+ L+R H L+ HH++ DGWS +++ E+++ YA + + Sbjct: 147 DLERGPLLRVSLLRLAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSRGLEVALPA 206 Query: 1633 LALRYRDYI----GWLQGRDQEATRRFWEIQLARLQQPTRLADAMPRPSTPQSGHGEHRE 1688 L ++Y DY W++ ++E +W L Q L PRP QS G Sbjct: 207 LPIQYADYALWQRSWMEAGEKERQLAYWTGLLGGEQPVLELPFDRPRP-VRQSHRGAQFI 265 Query: 1689 L-LDATLTARLNEAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELT 1747 L LD L+ L A+ + T L+ A++ LL RY+ A + G +A R T Sbjct: 266 LELDIDLSQALRRVAQQEGATAFALLLASFQALLYRYSGQAD---IRVGVPIANRNRVET 322 Query: 1748 GVEQLLGLFINTLPVIVATPPHQPAGDWM------RALQAQNLQ-------------ARE 1788 E+L+G F+NT V+ A + D + RAL+AQ Q R Sbjct: 323 --ERLIGFFVNT-QVLKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERS 379 Query: 1789 YEHTPLVDI-----QRWSGQGAQALFDSILVFENYPVDATLSQGAPAGLAFSSVRHREET 1843 H PL + G G FD L E+ D+ +Q F + Sbjct: 380 LSHNPLFQVLFNYQSEARGNGQAFRFDE-LQMESVQFDSRTAQ-------FDLTLDLTDE 431 Query: 1844 NYPMTVVVNAGDTLQLQLRYARAQFAHEMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPG 1903 V + YA F VER+ H R+LL+ + +P+Q +G L LL Sbjct: 432 EQRFCAVFD----------YATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLLDA 481 Query: 1904 DE----LAAWRESGVNRELHAFDAPVHRLIERQAAATPSAAALLYEDLVLDYRSLNQQAN 1959 E L+ W + RE A + + E QA P A AL+ ++ L Y LN +AN Sbjct: 482 PERRQTLSEWNPA--QREC-AVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNARAN 538 Query: 1960 RLAHRLLAEGAGPERIVGVAARRAPEMVVALLAVLKAGAAYLPLDPDLPPARLADMMADS 2019 RLAH L+A G G + VG+A R+ +M+V LLA+LKAG AYLPLDP P RLA ++ DS Sbjct: 539 RLAHCLIARGVGADVPVGLALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILDDS 598 Query: 2020 GLSLLLTQTALRAELTAPAAVRVLELDAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGS 2079 G+ LLLTQ L L A V VL +D +G + DP ++ D LAYVIYTSGS Sbjct: 599 GVRLLLTQGHLLERLPRQAGVEVLAIDG---LVLDGYAESDPLPTLSADNLAYVIYTSGS 655 Query: 2080 TGKPKGAGNRHVSLHNRLAWMQEAYPIGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLAL 2139 TGKPKG H + + + + + + FD SVWE F L+ G L + Sbjct: 656 TGKPKGTLLTHRNALRLFSATEAWFGFDERDVWTLFHSYAFDFSVWEIFGALLYGGCLVI 715 Query: 2140 AAPDEHRDPALLAARIRRHAVDTLHFVPSMLQAFVAHPDSA----QCHSLRQVICSGEAL 2195 R P + R V L+ PS + +A SA Q +LR VI GEAL Sbjct: 716 VPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEAL 775 Query: 2196 PAELQEQAFARL--PQIALHNLYGPTEAAIDVTHWTCRP-------GERSVPIGRPISHT 2246 + F R Q L N+YG TE + VT+ RP G PIG I Sbjct: 776 DLQSLRPWFQRFGDRQPQLVNMYGITETTVHVTY---RPVSEADLEGGLVSPIGGTIPDL 832 Query: 2247 AAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGRPGLSAERFVADPF-AADGSRMYRTGD 2305 + Y+LD LNP+P G GELY+G GLARGYL RPGLSA RFV +PF G R+YRTGD Sbjct: 833 SWYILDRDLNPVPRGAVGELYIGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGD 892 Query: 2306 LVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLLAQPGVAAAVVVALVEPGRPARLV 2365 L R +ADG IEY+GR DHQVK+RG RIELGEIEA L GV AVV+A G +LV Sbjct: 893 LARFQADGNIEYIGRIDHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVG-GTQLV 951 Query: 2366 GY-AADPGGMLE--AEALRAALLQSLPDYMVPQRLILLPALPLNANGKVDRKALPRPDFN 2422 GY AD E E+LR +L + LPDYMVP L+LL +PL NGK+DR+ALP+PD + Sbjct: 952 GYVVADSAEDAERLRESLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDAS 1011 Query: 2423 -EQGGYEAPQGQTEIGLAAIWAEVLRLQRVGRHDNFFELGGDSILSLQIVARA-HEQGWP 2480 Q Y AP + E +AAIW+E+L ++RVG DNFFELGG S+L+ ++++R EQ Sbjct: 1012 LSQQAYRAPGSELEQRIAAIWSEILGVERVGLDDNFFELGGHSLLATRVISRVRQEQQLD 1071 Query: 2481 LTPRQLFQSQTVAELAQ 2497 + + LF+ + AQ Sbjct: 1072 ASLKALFERPVLEAFAQ 1088 >PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1060 Score = 827 bits (2135), Expect = 0.0, Method: Compositional matrix adjust. Identities = 471/966 (48%), Positives = 608/966 (62%), Gaps = 14/966 (1%) Query: 17 EQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDAWSNPLVIRDLA 76 E+ L E +QA FDL + L V L+ L +HVLV+ HHIVSD WS +++ +L Sbjct: 87 EEGLIERIQAIVVQPFDLERGPLLRVNLLQLAEDDHVLVLVQHHIVSDGWSMQVMVEELV 146 Query: 77 EAYRQARRDGQAQLPALPMQYADYAHWQRQRVQGAWLADELRYWDDYLGPVNSSLDLPTD 136 + Y + LPALP+QYADYA WQR ++ +L YW LG L+LP D Sbjct: 147 QLYAAYSQGLDVVLPALPIQYADYALWQRSWMEAGEKERQLAYWTGLLGGEQPVLELPFD 206 Query: 137 RPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVLLSRYSGQADFFF 196 RPRPARQS RGA F L L + ++A + + + F+ L+A++Q LL RYSGQAD Sbjct: 207 RPRPARQSHRGAQLGFELSRELVEAVRALAQREGASSFMLLLASFQALLYRYSGQADIRV 266 Query: 197 F--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLAALEHGDLPFEAL 254 A RN E + L+GFFV TQ+ +A L + EL+ Q R L A H DLPFE L Sbjct: 267 GVPIANRNRVETERLIGFFVNTQVLKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQL 326 Query: 255 LEHRKVERDPGRNPLFQVMFGLQM-VGEGASALAFDDIVTAPLPLAQDSAKFDLSLDVKV 313 +E + ER+ NPLFQV+F Q + + +D+ L +A+FDL+LD++ Sbjct: 327 VEALQPERNASHNPLFQVLFNHQSEIRSVTPEVQLEDLRLEGLAWDGQTAQFDLTLDIQE 386 Query: 314 IKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALLDQDEQARLRSW 373 + + +YA+DLFDA+T+ +AGH++NLLRG A P + + +L LLD E+ + S Sbjct: 387 DENGIWASFDYATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSE 446 Query: 374 GDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRAANRLAHRLLQQ 433 +P RE +L E QA P AVA++ Q++SY +LN ANRLAH L+ + Sbjct: 447 WNPAQREC---AVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNARANRLAHCLIAR 503 Query: 434 GVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQDAGVTLALTAG 493 GVG + +GLA RSL+M+VGLLAILKAG AY+PLDP P +RLA+++ D+GV L LT G Sbjct: 504 GVGADVPVGLALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQG 563 Query: 494 EGVSALTAQ-GLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGSTGRPKGAQLSH 552 + L Q G+ L I + D A + +P L DNLAY+IYTSGSTG+PKG L+H Sbjct: 564 HLLERLPRQAGVEVLAIDGLVLDGYAES-DPLPTLSADNLAYVIYTSGSTGKPKGTLLTH 622 Query: 553 ANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVVVPFAVSRSPED 612 N LRL T AWF F DVWTLFHSYAFDFSVWEIFGAL YGGRLV+VP VSRSPED Sbjct: 623 RNALRLFSATEAWFGFDERDVWTLFHSYAFDFSVWEIFGALLYGGRLVIVPQWVSRSPED 682 Query: 613 FLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALRTVIFGGEALEPEMLRPWITQ 672 F LL + VTVLNQTPSAF+QL+ + + ++ ALR VIFGGEAL+ + LRPW + Sbjct: 683 FYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQR 742 Query: 673 FGDQRPALINMYGITETTVHVTYRRLLRADLDASR-SPIGAAIPDLGLYVLDQRLNLAPA 731 FGD++P L+NMYGITETTVHVTYR + ADL SPIG IPDL Y+LD+ LN P Sbjct: 743 FGDRQPQLVNMYGITETTVHVTYRPVSEADLKGGLVSPIGGTIPDLSWYILDRDLNPVPR 802 Query: 732 GVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEGSRLYRTGDLVRWRHDGQMDY 791 G GELY+ AGLARGYL R LSA RFV NPF G G RLYRTGDL R++ DG ++Y Sbjct: 803 GAVGELYIGRAGLARGYLRRPGLSATRFVPNPF--PGGAGERLYRTGDLARFQADGNIEY 860 Query: 792 LGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQDAATPRLVGYLSPQAGIAPEA 851 +GRID QVK+RGFRIELGEIEA L GV A V+ +LVGY+ + E Sbjct: 861 IGRIDHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADSAEDAER 920 Query: 852 LDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVDRKALPAPELA-ARTAYAAPQGA 910 L +LR +L LPDYMVPA L++L +PL +NGK+DR+ALP P+ + ++ AY AP Sbjct: 921 LRE-SLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSE 979 Query: 911 LEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVSR-ARRAGIAITARQMFERQTV 969 LE+++AAIW E+L VG DDNFFELGG S+L L + R ++ Q+ +V Sbjct: 980 LEQRIAAIWAEILGVERVGLDDNFFELGGHSLLLLMLKERIGDTCQATLSISQLMTHASV 1039 Query: 970 AELAAV 975 AE AA Sbjct: 1040 AEQAAC 1045 Score = 481 bits (1237), Expect = e-134, Method: Compositional matrix adjust. Identities = 398/1080 (36%), Positives = 540/1080 (50%), Gaps = 95/1080 (8%) Query: 1470 LSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGF-LHQ 1527 LS Q F EP +AY + + G LD ++++ VA H+ LRT F L Sbjct: 6 LSFAQERQWFLWQLEPESAAYHIPSALRLRGRLDVDALQRSFDSLVARHETLRTRFRLEG 65 Query: 1528 PRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGFDLAAPPLMRLVLVRT 1587 R Q V V+ + R+ + L + A+ + Q FDL PL+R+ L++ Sbjct: 66 GRSYQQVQPAVSVSIE----REQFGEEGLIERIQAI----VVQPFDLERGPLLRVNLLQL 117 Query: 1588 GAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAAGQAKPTKLALRYRDYI----GW 1643 H L+ HH++ DGWS +++ E+++ YA + L ++Y DY W Sbjct: 118 AEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSQGLDVVLPALPIQYADYALWQRSW 177 Query: 1644 LQGRDQEATRRFWEIQLARLQQPTRLADAMPRPSTPQSGHGEHRELLDATLTARLNEAAR 1703 ++ ++E +W L Q L PRP+ QS G L L+ L EA R Sbjct: 178 MEAGEKERQLAYWTGLLGGEQPVLELPFDRPRPAR-QSHRGAQ---LGFELSRELVEAVR 233 Query: 1704 A--QRITLNT--LVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINT 1759 A QR ++ L+ A++ LL RY+ A + G +A R T E+L+G F+NT Sbjct: 234 ALAQREGASSFMLLLASFQALLYRYSGQAD---IRVGVPIANRNRVET--ERLIGFFVNT 288 Query: 1760 LPVIVATPPHQPAGDWM------RALQAQNLQAREYE-------------HTPLVDIQRW 1800 V+ A + D + RAL+AQ Q +E H PL Sbjct: 289 -QVLKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERNASHNPLF----- 342 Query: 1801 SGQGAQALFDSILVFENYPVDATLSQGAPAGLAFSSVRHREETNYPMTVVVNAGDT-LQL 1859 Q LF+ + + L GLA+ + + +T+ + + + Sbjct: 343 -----QVLFNHQSEIRSVTPEVQLEDLRLEGLAWDG----QTAQFDLTLDIQEDENGIWA 393 Query: 1860 QLRYARAQFAHEMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDE----LAAWRESGVN 1915 YA F VER+ H R+LL+ + +P+Q +G L LL E L+ W + Sbjct: 394 SFDYATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSEWNPA--Q 451 Query: 1916 RELHAFDAPVHRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERI 1975 RE A + + E QA P A AL+ ++ L Y LN +ANRLAH L+A G G + Sbjct: 452 REC-AVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVP 510 Query: 1976 VGVAARRAPEMVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELT 2035 VG+A R+ +M+V LLA+LKAG AYLPLDP P RLA ++ DSG+ LLLTQ L L Sbjct: 511 VGLALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLP 570 Query: 2036 APAAVRVLELDAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHN 2095 A V VL +D +G + DP ++ D LAYVIYTSGSTGKPKG H + Sbjct: 571 RQAGVEVLAIDG---LVLDGYAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALR 627 Query: 2096 RLAWMQEAYPIGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARI 2155 + + + + + FD SVWE F L+ G RL + R P + Sbjct: 628 LFSATEAWFGFDERDVWTLFHSYAFDFSVWEIFGALLYGGRLVIVPQWVSRSPEDFYRLL 687 Query: 2156 RRHAVDTLHFVPSMLQAFVAHPDSA----QCHSLRQVICSGEALPAELQEQAFARL--PQ 2209 R V L+ PS + +A SA Q +LR VI GEAL + F R Q Sbjct: 688 CREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQ 747 Query: 2210 IALHNLYGPTEAAIDVTHWTCRP-------GERSVPIGRPISHTAAYVLDGGLNPLPHGI 2262 L N+YG TE + VT+ RP G PIG I + Y+LD LNP+P G Sbjct: 748 PQLVNMYGITETTVHVTY---RPVSEADLKGGLVSPIGGTIPDLSWYILDRDLNPVPRGA 804 Query: 2263 AGELYLGGIGLARGYLGRPGLSAERFVADPF-AADGSRMYRTGDLVRRRADGEIEYLGRT 2321 GELY+G GLARGYL RPGLSA RFV +PF G R+YRTGDL R +ADG IEY+GR Sbjct: 805 VGELYIGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRI 864 Query: 2322 DHQVKIRGLRIELGEIEAQLLAQPGVAAAVVVALVEPGRPARLVGY-AADPGGMLE--AE 2378 DHQVK+RG RIELGEIEA L GV AVV+A G +LVGY AD E E Sbjct: 865 DHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVG-GTQLVGYVVADSAEDAERLRE 923 Query: 2379 ALRAALLQSLPDYMVPQRLILLPALPLNANGKVDRKALPRPDFN-EQGGYEAPQGQTEIG 2437 +LR +L + LPDYMVP L+LL +PL NGK+DR+ALP+PD + Q Y AP + E Sbjct: 924 SLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSELEQR 983 Query: 2438 LAAIWAEVLRLQRVGRHDNFFELGGDSILSLQIVARAHEQGW-PLTPRQLFQSQTVAELA 2496 +AAIWAE+L ++RVG DNFFELGG S+L L + R + L+ QL +VAE A Sbjct: 984 IAAIWAEILGVERVGLDDNFFELGGHSLLLLMLKERIGDTCQATLSISQLMTHASVAEQA 1043 Score = 469 bits (1207), Expect = e-131, Method: Compositional matrix adjust. Identities = 380/1059 (35%), Positives = 536/1059 (50%), Gaps = 87/1059 (8%) Query: 2542 LSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTGFLWQA 2600 LS Q+ F P S Y ++R+ G LD +++ S++ARH +RT F + Sbjct: 6 LSFAQERQWFLWQLEPESAAYHIPSALRLRGRLDVDALQRSFDSLVARHETLRTRFRLEG 65 Query: 2601 GYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARGFDLLQPPLVRATLL 2660 G + Q V ++ IE + + L + I A + + FDL + PL+R LL Sbjct: 66 G--RSYQQVQPAVSVSIEREQFGEEG----LIERIQAI----VVQPFDLERGPLLRVNLL 115 Query: 2661 RLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGGQP------LPAPGPDYAQYI---- 2710 +L H LV HHI+ DGWS +++EL+ Y LPA YA Y Sbjct: 116 QLAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSQGLDVVLPALPIQYADYALWQR 175 Query: 2711 GWLATLDPQAAQRYWMGALQALDGPSLLAEGVRPDPARRGF--GKLYGHCDAAATRRLEQ 2768 W+ + + YW G L + P L RP PAR+ +L + Sbjct: 176 SWMEAGEKERQLAYWTGLLGG-EQPVLELPFDRPRPARQSHRGAQLGFELSRELVEAVRA 234 Query: 2769 FARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGLFINTIPIV 2828 A+ + + L+ ++ L R+ + G ++ R E+ +G F+NT + Sbjct: 235 LAQREGASSFMLLLASFQALLYRYSGQADIRVGVPIANRNRV--ETERLIGFFVNTQVLK 292 Query: 2829 VEVDGQRRVGDWLRTLQQTNIDSREHEHTPLYDI----QRWSGMAGRALFDSIIVFENFP 2884 ++DG+ + L +Q ++++ H+ P + Q + LF ++F + Sbjct: 293 ADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERNASHNPLFQ--VLFNHQS 350 Query: 2885 ISRSLEARAQAGLRFGQAEGEGLTGFAMDLQVVARE-TLDIE---------FCYDRSLFG 2934 RS+ Q E L G A D Q + TLDI+ F Y LF Sbjct: 351 EIRSVTPEVQL-------EDLRLEGLAWDGQTAQFDLTLDIQEDENGIWASFDYATDLFD 403 Query: 2935 DAELEALREQVMLNLDALSASGERALGELARL-SPQALAAVLELGRGTHDYPADLPAHLL 2993 + +E L L + A+ + LGEL L +P+ + E + Sbjct: 404 ASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSEWNPAQRECAVQGTLQQR 463 Query: 2994 IARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMVV 3053 +A P A+AL+L+EQ LSYGELN RANRLAH L++ GVGA+ VG+A+ERS DM+V Sbjct: 464 FEEQARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDMLV 523 Query: 3054 GLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLALD 3113 GLLA++KAG AY+PLD P ERLA+++ DS +++LLT L QA G+ LA+D Sbjct: 524 GLLAILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQA--GVEVLAID 581 Query: 3114 DADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALYE 3173 L G DP+ ++ +AYVIYTSGSTG+PKG ++H + AT A + Sbjct: 582 ----GLVLDGYAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWFG 637 Query: 3174 MTPQWRELQFMSFSFDGAHERWITTLISGAALVL------RGPEMWSIEQSWQALHQQRV 3227 + F S++FD + L+ G LV+ R PE + ++ L ++ V Sbjct: 638 FDERDVWTLFHSYAFDFSVWEIFGALLYGGRLVIVPQWVSRSPEDF-----YRLLCREGV 692 Query: 3228 SNAVFPPAYLGQL---AQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPR--LLIN 3282 + P+ QL A + P L +FGGEA+ S + R L+N Sbjct: 693 TVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQPQLVN 752 Query: 3283 GYGPTETVVTPLIWKGTSAAGVDFDGPFV-PIGKPVGRRNAYILDACLQPVAPGEAGELY 3341 YG TET V + ++ S A D G V PIG + + YILD L PV G GELY Sbjct: 753 MYGITETTVH-VTYRPVSEA--DLKGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGELY 809 Query: 3342 IGGDGLARGYLERPAQSAERFVADPF-GEPGARMYRTGDLARWLPDGNVEYLGRLDHQVK 3400 IG GLARGYL RP SA RFV +PF G G R+YRTGDLAR+ DGN+EY+GR+DHQVK Sbjct: 810 IGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVK 869 Query: 3401 IRGFRIELGEIEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQRD 3460 +RGFRIELGEIEA L GV + AVV+ DG G QLV YV A A E A+R Sbjct: 870 VRGFRIELGEIEAALAGLAGVRD-AVVLAHDGVGGT---QLVGYVVADSA----EDAER- 920 Query: 3461 FSDSLRAALRAGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPA-RSYVAPATPA 3519 +SLR +L+ LP+YM+PAH +LL +P+T NGKLDR+ALP P A+ + ++Y AP + Sbjct: 921 LRESLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSEL 980 Query: 3520 AQALAEIWQTVLKRERVGQEDNFFELGGDSLLCLQVIAR 3558 Q +A IW +L ERVG +DNFFELGG SLL L + R Sbjct: 981 EQRIAAIWAEILGVERVGLDDNFFELGGHSLLLLMLKER 1019 >all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1542 Score = 825 bits (2130), Expect = 0.0, Method: Compositional matrix adjust. Identities = 570/1513 (37%), Positives = 796/1513 (52%), Gaps = 109/1513 (7%) Query: 1 VQLAWLDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQL-DVRLIALGPQEHVLVIGMH 59 V + +DL+ LP +++Q++QE + A FDL AG L VRL+ LG VL++ +H Sbjct: 79 VNIPVIDLQGLPEFEQQQQVQELARTQAQQPFDL--AGLLWRVRLVKLGEGNQVLLLTLH 136 Query: 60 HIVSDAWSNPLVIRDLAEAYRQARRDGQAQL--PALPMQYADYAHWQRQRVQGAWLADEL 117 HI++DAWS L++R+++ A+ + R G+AQ +QY D+A WQR+ ++G L + L Sbjct: 137 HIIADAWSVGLLVREISRAFAE-RPAGKAQRRREEERIQYVDFAFWQREWLRGRVLEEHL 195 Query: 118 RYWDDYLGPVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVAL 177 YW L L+LPTD PRPA QSFRGAV+ F L + L Q +Q R H T F+ L Sbjct: 196 EYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSAELTQGLQGLSRRYHSTLFMTL 255 Query: 178 MAAWQVLLSRYSGQADFFFF--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQ 235 +A W VLL RYSG D A RN E + L+G F T R L+ + +L+ + Sbjct: 256 LAVWNVLLYRYSGDDDIVVGSPIANRNRVETEGLIGCFANTLALRTDLSANPSFADLLSR 315 Query: 236 VRGDMLAALEHGDLPFEALLEHRKVERDPGRNPLFQVMFGLQMVGEGASALAFDDIVTAP 295 VR L A H DLPFE L++ + R +PLFQVM LQ + L I Sbjct: 316 VRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLVLQNLP--LPELDMGGIEWQV 373 Query: 296 LPLAQDSAKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERP 355 + +AKFDL+ V + C+LEY +DLF A TI +AGH + LL+ PE+ Sbjct: 374 IEADSGTAKFDLTWFVSETAQGLSCKLEYNTDLFAATTIERLAGHLETLLQAVVLNPEQH 433 Query: 356 VAQLALLDQDEQARLRSWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMS 415 + +L LL EQ +L W Q + P L L EAQ P+ +AV+ G +Q++ Sbjct: 434 INELPLLTTVEQQQLAQWNATQRQ-----YPQQCLHELFEAQVRQTPEKIAVIWGEKQLT 488 Query: 416 YAQLNRAANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPAD 475 Y +LN AN+LA L GV PE +G+ RSL+MI+GLLAILKA AYVPLDP YP Sbjct: 489 YQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMIIGLLAILKADGAYVPLDPTYPEA 548 Query: 476 RLAYMVQDAGVTLALTAGEGVSALTAQGLRTLEIAPALADDAAPAHNPGVVLHP---DNL 532 RLA++++D+ + + LT + ++ L L+I P ++ D V P NL Sbjct: 549 RLAFIIEDSQMQVLLTQQKQLTKLPQ-----LQI-PIISLDTPIPSPQSPVPSPQSPTNL 602 Query: 533 AYIIYTSGSTGRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGA 592 AYIIYTSG+TG PKG ++H + + L+ + S FD S++EIF Sbjct: 603 AYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYTRAELTGVLASTSICFDLSIFEIFVP 662 Query: 593 LCYGGRLVVVPFAVSRSPEDFLALLVEQRVTVLNQTPSAFRQLLQLPALRQLPSEALALR 652 L +GG +++ A+ + PE L +VT++N PSA R+LL+L + A ++ Sbjct: 663 LSWGGCVILADNAL-QLPE----LPAAAQVTLINTVPSAARELLRLNGI------AATVQ 711 Query: 653 TVIFGGEALEPEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRADLDASRSP-IG 711 TV GE L ++ Q +R + N+YG +E T + T+ + R ++ ++P IG Sbjct: 712 TVNLAGEPLPKSLVDELYQQSTIER--VYNLYGPSEDTTYSTHALIPR---NSQQAPTIG 766 Query: 712 AAIPDLGLYVLDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEG 771 I + +Y+LDQ L P G+PGE+Y+SGAGLARGY R L+ ERF+ + + Sbjct: 767 QPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKLTDERFIKQSTVNSQQST 826 Query: 772 -SRLYRTGDLVRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQ 830 + LY+TGD R+ DG ++YLGR D QVK+RGFRIELGEIEA L P + A +VR Sbjct: 827 VNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEALLHQHPELTQAVAIVRN 886 Query: 831 DAAT-PRLVGYLSPQAGIAPEALDTGALRTALGAVLPDYMVPAALVVLPALPLNINGKVD 889 D RLV Y+ P++ I + LR L A LP YM+P A V+L LPL NGKVD Sbjct: 887 DTPEHSRLVAYVVPKSHI-----EAAELRQFLAAKLPAYMLPTAFVILETLPLTANGKVD 941 Query: 890 RKALPAPELAARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVS 949 R ALP P+L+ T AP+ +E+QL IW +VL ++ DNFF LGGDSIL++Q V+ Sbjct: 942 RFALPIPDLSPVTTTTAPRTPIEQQLINIWTQVLGVESISIHDNFFRLGGDSILAIQAVA 1001 Query: 950 RARRAGIAITARQMFERQTVAELAAVASEAVAAATPRAITHTAQAGQACRLLPIQQDFFE 1009 +A + G+A+ RQMF+ QTVAELAA+ V T + T G+ L PIQQ FFE Sbjct: 1002 KANQQGLALRPRQMFQYQTVAELAAI----VDTDTTLSSEQTPITGE-VPLTPIQQWFFE 1056 Query: 1010 ADIPRRAHWNQSVLLHSDAPIDPAALAAALHALMQAHPALTMRYAQHSDGW-------HQ 1062 ++ HWNQ++LL ++P L AL L+ H L + Q DGW +Q Sbjct: 1057 QNLVDAHHWNQAILLEVHQSLNPDYLRQALDQLLAHHDGLRSHFQQTPDGWRQFVADINQ 1116 Query: 1063 LH---------------GELPTLQAIAERIVSA-RAADAEQLLAL------------CES 1094 LH GE+ + ER+ D +L L Sbjct: 1117 LHNTQKPNPQPLLYKGRGEIKASLPLGERLGEGFYYFDMSELTNLHPEKVSDTIANIAND 1176 Query: 1095 AQRSLDLEHGLVLRAVLVDMGQA-GWRLLLVAHHLVIDGVSWRVLLEDMQHAYAHACATP 1153 Q S +LE +LR D G+ RLLL+ HHL+IDG+SWRV LED+Q AY Sbjct: 1177 LQASFNLETPPLLRLAYFDCGETQNHRLLLIFHHLIIDGISWRVFLEDLQLAYQQLSQGQ 1236 Query: 1154 EQPLQLPAEEAGLAEWGEALAAYAPVAAQR--IDHWLGLAGCPV--QLPSDPARAGEEGA 1209 + QLP + +W L + A + ++W P Q+P P Sbjct: 1237 QI--QLPPKTTSYQQWANKLQEHTWSADLQAAFNYW----TSPTWQQIPPLPVDYAPGSN 1290 Query: 1210 SARLADQQSVLLRLTPALTQTLIGEAHSAWRTQVNDLLLAALARALAAWGAPQPLLVDLE 1269 + D S L +T TQ L+ E A+RTQ+ND+LL AL A W LLV+LE Sbjct: 1291 TMADVDTYSTFLSVTD--TQNLLQEVPHAYRTQINDVLLTALVLAFQTWTGENRLLVELE 1348 Query: 1270 GHGREALGDGAATPDLSRTVGWFTSVFPLALEA--SGTPLATLLRTKESLRALPNKGLDF 1327 GHGRE D + +LSRT+GWFTS+FP+ L+ S +L KE LR +P++G+ + Sbjct: 1349 GHGRE---DLFPSINLSRTMGWFTSLFPVLLDIYPSADLGISLKAIKEQLRQIPDRGISY 1405 Query: 1328 GVLLRFGTAEQRDALQALPRAQVAFNYLGQFQS--GEEGGWRLASESAGTPMDPHAAMRH 1385 G+L + RD ++A+P QV FNYLGQ E + ASES G Sbjct: 1406 GLLRYLASPTIRDTIKAIPLPQVRFNYLGQSDQIFSENSLFTPASESIGHSRSSRGKRNT 1465 Query: 1386 ALTINGQVHEGVLQLRLNYCGKRYGRAMVETLAAHLQTQLEELAALC-SQHAGGLTPSDL 1444 + IN V G L+ Y + + R + TLA + Q L L C + G TPSD Sbjct: 1466 LIEINSIVTGGKLRCDWTYSKQLHHRQTIATLAENYQQILLSLIQHCLTPEVSGFTPSDF 1525 Query: 1445 PLAGLDQAQLDAL 1457 P Q +LD L Sbjct: 1526 PQMDFSQDELDKL 1538 Score = 515 bits (1326), Expect = e-145, Method: Compositional matrix adjust. Identities = 455/1444 (31%), Positives = 667/1444 (46%), Gaps = 122/1444 (8%) Query: 1469 PLSPMQAGMLFHSVFEPGGSAYINQLRVDIDG-LDAARFEQAWQDTVAAHDILRTGFLH- 1526 PLS Q + EP Y L V I G + ++++ + V +ILR+ FL+ Sbjct: 6 PLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHFLNV 65 Query: 1527 QPRPLQWVARRVASPLSQLDWRDAAAGQALGGELDALAQRQLAQGFDLAAPPLMRLVLVR 1586 +P+ +A + +D + ++ LA+ Q Q FDLA L R+ LV+ Sbjct: 66 DGQPVLRIADVCDVNIPVIDLQ-GLPEFEQQQQVQELARTQAQQPFDLAGL-LWRVRLVK 123 Query: 1587 TGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATAA-GQAKPTKLALRYRDYI---- 1641 G L+ T+HH++ D WS +L+ E+ R +A+ A Q + + ++Y D+ Sbjct: 124 LGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYVDFAFWQR 183 Query: 1642 GWLQGRDQEATRRFWEIQLARLQQPTRLADAMPRPSTPQSGHGEHRELLDATLTARLNEA 1701 WL+GR E +W QL L PRP+ + L A LT L Sbjct: 184 EWLRGRVLEEHLEYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSAELTQGLQGL 243 Query: 1702 ARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAGRPAELTGVEQLLGLFINTLP 1761 +R TL + A W +LL RY + D +V G+ +A R E L+G F NTL Sbjct: 244 SRRYHSTLFMTLLAVWNVLLYRY---SGDDDIVVGSPIANR--NRVETEGLIGCFANTLA 298 Query: 1762 VIVATPPHQPAGDWMRALQAQNLQAREYEHTP---LVDI-QRWSGQGAQALFDSILVFEN 1817 + + D + ++A L A ++ P LVD+ Q LF +LV +N Sbjct: 299 LRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLVLQN 358 Query: 1818 YPVDATLSQGAPAGLAFSSVRHREET-NYPMT-VVVNAGDTLQLQLRYARAQFAHEMVER 1875 P+ L G G+ + + T + +T V L +L Y FA +ER Sbjct: 359 LPL-PELDMG---GIEWQVIEADSGTAKFDLTWFVSETAQGLSCKLEYNTDLFAATTIER 414 Query: 1876 IGAHLRHLLQVLAEHPQQAIGSLGLLPGDE---LAAWRESGVNRELHAFDAPVHRLIERQ 1932 + HL LLQ + +P+Q I L LL E LA W + +H L E Q Sbjct: 415 LAGHLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQQC----LHELFEAQ 470 Query: 1933 AAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGPERIVGVAARRAPEMVVALLA 1992 TP A+++ + L Y+ LN +AN+LA L + G PE VG+ R+ +M++ LLA Sbjct: 471 VRQTPEKIAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMIIGLLA 530 Query: 1993 VLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRAELTAPAAVRVLELDAPGQPW 2052 +LKA AY+PLDP P ARLA ++ DS + +LLTQ +L + ++ LD Sbjct: 531 ILKADGAYVPLDPTYPEARLAFIIEDSQMQVLLTQQKQLTKLPQ-LQIPIISLDT----- 584 Query: 2053 AEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVSLHNRLAWMQEAYPIGPGNTV 2112 P +P LAY+IYTSG+TG PKG H S + W +E Y V Sbjct: 585 PIPSPQSPVPSPQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYTRAELTGV 644 Query: 2113 LQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPALLAARIRRHAVDTLHFVPSMLQA 2172 L T FD+S++E F PL G + LA + + P L AA V ++ VPS + Sbjct: 645 LASTSICFDLSIFEIFVPLSWGGCVILAD-NALQLPELPAAA----QVTLINTVPSAARE 699 Query: 2173 FVAHPDSAQCHSLRQVICSGEALPAELQEQAFARLPQIALHNLYGPTEAAIDVTHWTC-R 2231 + A +++ V +GE LP L ++ + + ++NLYGP+E TH R Sbjct: 700 LLRLNGIAA--TVQTVNLAGEPLPKSLVDELYQQSTIERVYNLYGPSEDTTYSTHALIPR 757 Query: 2232 PGERSVPIGRPISHTAAYVLDGGLNPLPHGIAGELYLGGIGLARGYLGRPGLSAERFV-- 2289 +++ IG+PI++T Y+LD L P+P GI GE+YL G GLARGY RP L+ ERF+ Sbjct: 758 NSQQAPTIGQPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKLTDERFIKQ 817 Query: 2290 --ADPFAADGSRMYRTGDLVRRRADGEIEYLGRTDHQVKIRGLRIELGEIEAQLLAQPGV 2347 + + + +Y+TGD R DG IEYLGR DHQVK+RG RIELGEIEA L P + Sbjct: 818 STVNSQQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEALLHQHPEL 877 Query: 2348 AAAVVVALVEPGRPARLVGYAADPGGMLEAEALRAALLQSLPDYMVPQRLILLPALPLNA 2407 AV + + +RLV Y P +EA LR L LP YM+P ++L LPL A Sbjct: 878 TQAVAIVRNDTPEHSRLVAYVV-PKSHIEAAELRQFLAAKLPAYMLPTAFVILETLPLTA 936 Query: 2408 NGKVDRKALPRPDFNEQGGYEAPQGQTEIGLAAIWAEVLRLQRVGRHDNFFELGGDSILS 2467 NGKVDR ALP PD + AP+ E L IW +VL ++ + HDNFF LGGDSIL+ Sbjct: 937 NGKVDRFALPIPDLSPVTTTTAPRTPIEQQLINIWTQVLGVESISIHDNFFRLGGDSILA 996 Query: 2468 LQIVARAHEQGWPLTPRQLFQSQTVAELAQQCDQLQPPAPAQAVTAARGRLEDYLSAAQT 2527 +Q VA+A++QG L PRQ+FQ QTVAELA D + LS+ QT Sbjct: 997 IQAVAKANQQGLALRPRQMFQYQTVAELAAIVDT-----------------DTTLSSEQT 1039 Query: 2528 AQLALQGELEDVYPLSPMQQGMLFHTMESPGSGLYVNQLSVRVEGLDEARFAQAWQSVLA 2587 + GE+ PL+P+QQ + L V + L+ QA +LA Sbjct: 1040 ---PITGEV----PLTPIQQWFFEQNLVDAHHWNQAILLEVH-QSLNPDYLRQALDQLLA 1091 Query: 2588 RHPVMRTGFL-----WQAGYA-------------QPLQAVWR-----TLAFGIEVQDWSA 2624 H +R+ F W+ A QPL R +L G + + Sbjct: 1092 HHDGLRSHFQQTPDGWRQFVADINQLHNTQKPNPQPLLYKGRGEIKASLPLGERLGEGFY 1151 Query: 2625 RADDAEL----PQAIA---AFAAADLARGFDLLQPPLVRATLLRLGPGQ-HQLVWTMHHI 2676 D +EL P+ ++ A A DL F+L PPL+R G Q H+L+ HH+ Sbjct: 1152 YFDMSELTNLHPEKVSDTIANIANDLQASFNLETPPLLRLAYFDCGETQNHRLLLIFHHL 1211 Query: 2677 LLDGWSTSALMQELMLAY------GGQPLPAPGPDYAQYIGWLA----TLDPQAAQRYWM 2726 ++DG S +++L LAY LP Y Q+ L + D QAA YW Sbjct: 1212 IIDGISWRVFLEDLQLAYQQLSQGQQIQLPPKTTSYQQWANKLQEHTWSADLQAAFNYWT 1271 Query: 2727 GAL--QALDGPSLLAEGVRPDPARRGFGKLYGHCDAAATRRLEQFARSQRVTLNTLVQGA 2784 Q P A G + D L++ + R +N ++ A Sbjct: 1272 SPTWQQIPPLPVDYAPGSNTMADVDTYSTFLSVTDTQ--NLLQEVPHAYRTQINDVLLTA 1329 Query: 2785 WSLALARHKRSTAVAFGATVSGRPAALPGVE--KSLGLFINTIPIVVEVDGQRRVGDWLR 2842 LA + GR P + +++G F + P+++++ +G L+ Sbjct: 1330 LVLAFQTWTGENRLLVELEGHGREDLFPSINLSRTMGWFTSLFPVLLDIYPSADLGISLK 1389 Query: 2843 TLQQ 2846 +++ Sbjct: 1390 AIKE 1393 Score = 435 bits (1118), Expect = e-120, Method: Compositional matrix adjust. Identities = 346/1061 (32%), Positives = 503/1061 (47%), Gaps = 99/1061 (9%) Query: 2541 PLSPMQQGMLFHTMESPGSGLYVNQLSVRVEG-LDEARFAQAWQSVLARHPVMRTGFLWQ 2599 PLS QQ P S Y L+V++ G + +++ V+ R ++R+ FL Sbjct: 6 PLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHFLNV 65 Query: 2600 AGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAAFAAADLARG-----FDLLQPPL 2654 G QP+ + I V D LP+ +LAR FDL L Sbjct: 66 DG--QPVLRIADVCDVNIPVIDLQG------LPEFEQQQQVQELARTQAQQPFDL-AGLL 116 Query: 2655 VRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYGGQPLPAPG----PDYAQYI 2710 R L++LG G L+ T+HHI+ D WS L++E+ A+ +P + QY+ Sbjct: 117 WRVRLVKLGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYV 176 Query: 2711 G-------WLATLDPQAAQRYWMGALQALDGPSLLAEGV-RPDPARRGF-GKLYGH-CDA 2760 WL + YW G L++ P +L P PA + F G +YG A Sbjct: 177 DFAFWQREWLRGRVLEEHLEYWRGQLES--APVMLELPTDYPRPAVQSFRGAVYGFGLSA 234 Query: 2761 AATRRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSGRPAALPGVEKSLGL 2820 T+ L+ +R TL + W++ L R+ + G+ ++ R E +G Sbjct: 235 ELTQGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANRNRV--ETEGLIGC 292 Query: 2821 FINTIPIVVEVDGQRRVGDWLRTLQQTNIDSREHEHTP---LYDI-QRWSGMAGRALFDS 2876 F NT+ + ++ D L ++ T + + H+ P L D+ Q ++ LF Sbjct: 293 FANTLALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQV 352 Query: 2877 IIVFENFPISRSLEARAQAGLRFGQAEGEGLTGFAMDLQVVARET---LDIEFCYDRSLF 2933 ++V +N P L G+ + E + T DL ET L + Y+ LF Sbjct: 353 MLVLQNLP----LPELDMGGIEWQVIEADSGTA-KFDLTWFVSETAQGLSCKLEYNTDLF 407 Query: 2934 GDAELEALREQVMLNLDALSASGERALGELARLSPQALAAVLELGRGTHDYPADLPAHLL 2993 +E L + L A+ + E+ + EL L+ + + YP H L Sbjct: 408 AATTIERLAGHLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQQC-LHEL 466 Query: 2994 IARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVGAEQRVGVAVERSFDMVV 3053 + TP+ IA++ E+ L+Y ELN +AN+LA HL SLGV E VG+ V+RS DM++ Sbjct: 467 FEAQVRQTPEKIAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMII 526 Query: 3054 GLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARARRLLAAQAQPGLRCLALD 3113 GLLA++KA AYVPLD YP RLA+++ DS++QVLLT + L Q + ++LD Sbjct: 527 GLLAILKADGAYVPLDPTYPEARLAFIIEDSQMQVLLTQQKQ---LTKLPQLQIPIISLD 583 Query: 3114 DADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAVSHGPLVMHCQATAALYE 3173 + Q +P +AY+IYTSG+TG PKGVA++H V +Y Sbjct: 584 TPIPSPQSPV------PSPQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYT 637 Query: 3174 MTPQWRELQFMSFSFDGAHERWITTLISGAALV-----LRGPEMWSIEQSWQALHQQRVS 3228 L S FD + L G ++ L+ PE+ A Q + Sbjct: 638 RAELTGVLASTSICFDLSIFEIFVPLSWGGCVILADNALQLPEL-------PAAAQVTLI 690 Query: 3229 NAVFPPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLAPRLLINGYGPTE 3288 N V P+ +L + +G A ++ GE +P++ + + + + N YGP+E Sbjct: 691 NTV--PSAARELLRL---NGIAATVQTVNLAGEPLPKSLVDELYQQSTIERVYNLYGPSE 745 Query: 3289 TVVTP---LIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGEAGELYIGGD 3345 LI + + A IG+P+ YILD LQPV G GE+Y+ G Sbjct: 746 DTTYSTHALIPRNSQQAPT--------IGQPIANTQVYILDQNLQPVPVGIPGEIYLSGA 797 Query: 3346 GLARGYLERPAQSAERFV----ADPFGEPGARMYRTGDLARWLPDGNVEYLGRLDHQVKI 3401 GLARGY +RP + ERF+ + +Y+TGD AR+LPDGN+EYLGR DHQVK+ Sbjct: 798 GLARGYWKRPKLTDERFIKQSTVNSQQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKL 857 Query: 3402 RGFRIELGEIEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAPQAVAAPETAQRDF 3461 RGFRIELGEIEALL + P + +A +VR+D +LVAYV + A E Sbjct: 858 RGFRIELGEIEALLHQHPELTQAVAIVRNDTPEHS---RLVAYVVPKSHIEAAE------ 908 Query: 3462 SDSLRAALRAGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAPARSYVAPATPAAQ 3521 LR L A LP YMLP FV+L LP+T NGK+DR ALP P +P + AP TP Q Sbjct: 909 ---LRQFLAAKLPAYMLPTAFVILETLPLTANGKVDRFALPIPDLSPVTTTTAPRTPIEQ 965 Query: 3522 ALAEIWQTVLKRERVGQEDNFFELGGDSLLCLQVIARARGQ 3562 L IW VL E + DNFF LGGDS+L +Q +A+A Q Sbjct: 966 QLINIWTQVLGVESISIHDNFFRLGGDSILAIQAVAKANQQ 1006 >all2648_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1525 Score = 819 bits (2116), Expect = 0.0, Method: Compositional matrix adjust. Identities = 525/1483 (35%), Positives = 788/1483 (53%), Gaps = 88/1483 (5%) Query: 6 LDLRQLPPQQREQRLQEELQAAAAHVFDLGQAGQLDVRLIALGPQEHVLVIGMHHIVSDA 65 +DL LPP Q+++ +QE Q + F+L + L + + L QE++L++ MHHI++D Sbjct: 84 VDLSFLPPSQQQKLVQELAQEESQQPFNLEISPLLRAKFLYLNTQEYILLLTMHHIITDG 143 Query: 66 WSNPLVIRDLAEAYRQARRDGQAQ-LPALPMQYADYAHWQRQRVQGAWLADELRYWDDYL 124 WS + +++A Y QA GQ+ L L +QYAD+A WQR Q ++ YW L Sbjct: 144 WSINVFAQEMATIY-QAFSQGQSSPLQPLKIQYADFAVWQRS--QSDKFNYQVEYWRQQL 200 Query: 125 GPVNSSLDLPTDRPRPARQSFRGAVHAFTLDSALAQQMQAFCRAQHCTPFVALMAAWQVL 184 LDLPTD PRPA Q+FRG H+FT+ L ++++ + H T F+ + +A+ +L Sbjct: 201 ESAPELLDLPTDYPRPAIQTFRGQRHSFTISEELTEKIKQLGQETHTTLFMVMFSAFSIL 260 Query: 185 LSRYSGQADFFFF--FAGRNHAELQDLVGFFVTTQLYRARLTPELTVRELVRQVRGDMLA 242 L RYS Q A R++ + L+GFFV T L TV EL+ +VR +L+ Sbjct: 261 LHRYSQQEKIVIGSPVANRHYPGTEGLIGFFVNTFALLISLEDNPTVAELLPRVREMVLS 320 Query: 243 ALEHGDLPFEALLEHRKVERDPGRNPLFQVMFGLQMVGEGASALAFDDIVTAPLPLAQDS 302 A H D+PFE ++E K+ R +PLFQVM ++ + + +PL + + Sbjct: 321 AYSHQDVPFEQVVEELKLVRSLSHSPLFQVMLAVE--NAPTQPIEIPGLRWSPLEIDGGT 378 Query: 303 AKFDLSLDVKVIKGEVHCRLEYASDLFDAATIAAMAGHYQNLLRGFAAAPERPVAQLALL 362 AKFD++L + + + EY DLF TI H QN+L G + P + ++ L L+ Sbjct: 379 AKFDITLMIAETDAGLQGKWEYNCDLFTETTIHRFTEHLQNILLGMTSEPSQKISDLPLM 438 Query: 363 DQDEQARLRSWGDPQLREALPPTPGASLAGLIEAQAAAIPDAVAVVCGPQQMSYAQLNRA 422 E ++ ++G + + L E Q A D +AV+C Q+++Y++LN Sbjct: 439 SGGELQQIINFGTSPTNLII-----HCIQELFEQQVAKFGDEIAVICQHQKLTYSELNTK 493 Query: 423 ANRLAHRLLQQGVGPENRIGLAAPRSLEMIVGLLAILKAGAAYVPLDPDYPADRLAYMVQ 482 AN+LA+ L GV PE +G+ RSL+ I+G+LAILKAG YVPLDP YP +RL ++++ Sbjct: 494 ANQLAYHLKSLGVQPEIAVGICVHRSLDFIIGILAILKAGGFYVPLDPTYPQERLEFLIE 553 Query: 483 DAGVTLALTAGEGVSALTAQGLRTLEIAPALADDAAPAHNPGVVLHPDNLAYIIYTSGST 542 DA + + LT + + L + + A P NP P+NLAY++YTSGST Sbjct: 554 DAQIQVILTQQQHIPQLPDLPIFCFDTDTANLTQH-PTTNPVNHTTPENLAYVMYTSGST 612 Query: 543 GRPKGAQLSHANVLRLLGQTAAWFDFGREDVWTLFHSYAFDFSVWEIFGALCYGGRLVVV 602 G PKG + H V+RL+ + + + ++ +FD S +EI+GAL G RLV++ Sbjct: 613 GVPKGVCIPHRGVVRLV-KDCNYINLSADESILQAAPISFDASTFEIWGALLNGSRLVIL 671 Query: 603 PFAVSRSPE--DFLALLVEQRVTVLNQTPSAFRQLL--QLPALRQLPSEALALRTVIFGG 658 ++ P + + + ++T L T F ++ L +L+ +++ +I GG Sbjct: 672 S---NQQPTLAEIGQAITQHQITTLWLTAGLFHLMVDEHLESLK-------SVKQLIAGG 721 Query: 659 EALEPEMLRPWITQFGDQRPALINMYGITETTVHVTYRRLLRADLDASRS-PIGAAIPDL 717 + L + + + + R +IN YG TE T + D+ S + PIG I + Sbjct: 722 DVLSAVHINKLLQTYPECR--VINGYGPTENTTFTCCYSV--TDICESNTVPIGRPINNT 777 Query: 718 GLYVLDQRLNLAPAGVPGELYVSGAGLARGYLNRAALSAERFVANPFARAGEEG------ 771 +Y+LD LN P GVPGELY++G GLARGYLN+ L+AE+F+ N G+ G Sbjct: 778 QVYILDNHLNPLPVGVPGELYIAGDGLARGYLNQPTLTAEKFI-NWGLGTGDWGLGTTTL 836 Query: 772 SRLYRTGDLVRWRHDGQMDYLGRIDQQVKIRGFRIELGEIEAQLLAQPGVGAATVMVRQD 831 S LY+TGD R+ DG ++YLGR+D QVKIRGFRIELGEIEA L P V V+ R+ Sbjct: 837 STLYKTGDRARYLADGNIEYLGRLDNQVKIRGFRIELGEIEAVLNQHPAVKECVVIAREK 896 Query: 832 AATPRLVGYLSPQAGIAPEALDT--GALRTALGAVLPDYMVPAALVVLPALPLNINGKVD 889 +L+ Y ALD LR L LPDY++P V L LPL +NGKVD Sbjct: 897 ----QLIAYFI--------ALDNTPDNLREFLQQRLPDYLIPHFFVALETLPLTVNGKVD 944 Query: 890 RKALPAPELAARTAYAAPQGALEEQLAAIWREVLKGGAVGRDDNFFELGGDSILSLQIVS 949 R+ LPAPE+ + + +E +L IW VL V DNFF LGGDSIL++Q++S Sbjct: 945 RQKLPAPEITSFPDGTVARSDIEAKLLEIWSSVLNLSQVSIYDNFFALGGDSILAIQLIS 1004 Query: 950 RARRAGIAITARQMFERQTVAELAAVASEAVAAATPRAITHTAQAGQACRLLPIQQDFFE 1009 +A + G+ +T +Q+F+ QT+AELA V + ++ P+ + A +L PIQ FFE Sbjct: 1005 KANQVGLQLTPKQLFQYQTIAELAGVFTVDKSSLLPQGM-----VTGAVQLTPIQCWFFE 1059 Query: 1010 ADIPRRAHWNQSVLLHSDAPIDPAALAAALHALMQAHPALTMRY------AQHSDGWHQL 1063 ++ + H+NQ V L S + L A ++ L+ H L ++ Q G + Sbjct: 1060 QELVNQHHFNQVVFLESGEKLQQEVLVAVINKLLLHHDMLRCQFGEKNFITQRRRGAERE 1119 Query: 1064 HGELPTLQAIAERIVSARA--ADAEQLLALCESA---QRSLDLEHGLVLRAVLVDMGQAG 1118 GE+ L + + + +EQ + E A Q L++ + +LR V D+G+ Sbjct: 1120 IGEVVELGGDVPLVFCDLSGLSGSEQDRVIQEVAGEVQAGLNIGYAPLLRVVHFDLGEVS 1179 Query: 1119 WRLLLVAHHLVIDGVSWRVLLEDMQHAYAHACATPEQPLQLPAEEAGLAEWGEALAAYA- 1177 RLL+V HHLV+DGVSWR+LL D Q AY A A +Q + LPA+ W E L YA Sbjct: 1180 -RLLIVIHHLVVDGVSWRILLADFQTAYQQALA--KQTISLPAKTTSFLTWAEKLYDYAR 1236 Query: 1178 -PVAAQRIDHWLGLAGCPVQ-LPSDPARAGEEGASARLADQQSVLLRLTPALTQTLIGEA 1235 +++WL V+ LP D G + + D ++V ++L+ TQ L+ E Sbjct: 1237 SECLQDELEYWLSNKYQQVKRLPIDYPDGGNQ-----VVDVETVTIKLSVEDTQALLTEV 1291 Query: 1236 HSAWRTQVNDLLLAALARALAAWGAPQPLLVDLEGHGREALGDGAATPDLSRTVGWFTSV 1295 + TQ+ND+LL AL ++ W +L+DLEG+GR G+ D+SRTVGWFT++ Sbjct: 1292 SPVYNTQINDVLLTALTATISTWIDNPLVLLDLEGYGRNFPGEDI---DISRTVGWFTTI 1348 Query: 1296 FPLALEASGTPLATLLR-TKESLRALPNKGLDFGVLLRFGTAEQRDALQALPRAQVAFNY 1354 +P L LL+ KE LRA+PN+G +G+L +E L+ LP+A+++FNY Sbjct: 1349 YPCLLSKESDDWGELLKGIKEQLRAVPNQGFGYGILRYLDDSEASQRLRDLPQAEISFNY 1408 Query: 1355 LGQFQSG-EEGGWRLASESAGTPMDPHAAMRHALTINGQVHEGVLQLRLNYCGKRYGRAM 1413 LGQ G E G + T D R+A+ I G V EG LQ Y ++Y + Sbjct: 1409 LGQLDLGLEHGKLKWLPLPGITTQDKQQTRRYAIEIVGFVREGKLQFDWIYSQQQYQQET 1468 Query: 1414 VETLAAHLQTQLEELAALCS-QHAGGLTPSDLPLAGLDQAQLD 1455 + LA + Q L+ + C + GG TPSD LA L+Q LD Sbjct: 1469 ISQLANNFQQGLQAIINHCRLPNVGGYTPSDFELANLNQETLD 1511 Score = 489 bits (1260), Expect = e-137, Method: Compositional matrix adjust. Identities = 374/1231 (30%), Positives = 582/1231 (47%), Gaps = 114/1231 (9%) Query: 1508 QAWQDTVAAHDILRTGFLH-QPRPLQWVARRVAS--PLSQLDWRDAAAGQALGGELDALA 1564 Q+ Q+ + H+ILRT F++ + + +A + S P+ L + + Q L EL A Sbjct: 46 QSLQEIIHRHEILRTSFVNVDGQGIAVIATEINSHIPVVDLSFLPPSQQQKLVQEL---A 102 Query: 1565 QRQLAQGFDLAAPPLMRLVLVRTGAQRHHLIWTVHHLLLDGWSTSMLLGEVLRRYAQATA 1624 Q + Q F+L PL+R + Q + L+ T+HH++ DGWS ++ E+ Y QA + Sbjct: 103 QEESQQPFNLEISPLLRAKFLYLNTQEYILLLTMHHIITDGWSINVFAQEMATIY-QAFS 161 Query: 1625 AGQAKPTK-LALRYRDYIGWLQGRDQEATRR--FWEIQLARLQQPTRLADAMPRPSTPQS 1681 GQ+ P + L ++Y D+ W + + + + +W QL + L PRP+ Sbjct: 162 QGQSSPLQPLKIQYADFAVWQRSQSDKFNYQVEYWRQQLESAPELLDLPTDYPRPAIQTF 221 Query: 1682 GHGEHRELLDATLTARLNEAARAQRITLNTLVQAAWALLLQRYTYAAHDQGVVFGATVAG 1741 H + LT ++ + + TL ++ +A+++LL RY + + +V G+ VA Sbjct: 222 RGQRHSFTISEELTEKIKQLGQETHTTLFMVMFSAFSILLHRY---SQQEKIVIGSPVAN 278 Query: 1742 RPAELTGVEQLLGLFINTLPVIVATPPHQPAGDWMRALQAQNLQAREYEHTP----LVDI 1797 R G E L+G F+NT ++++ + + + ++ L A ++ P + ++ Sbjct: 279 R--HYPGTEGLIGFFVNTFALLISLEDNPTVAELLPRVREMVLSAYSHQDVPFEQVVEEL 336 Query: 1798 QRWSGQGAQALFDSILVFENYPVDATLSQGAPAGLAFSSVRHREET-NYPMTVVVNAGDT 1856 + LF +L EN P GL +S + T + +T+++ D Sbjct: 337 KLVRSLSHSPLFQVMLAVENAPTQPI----EIPGLRWSPLEIDGGTAKFDITLMIAETDA 392 Query: 1857 -LQLQLRYARAQFAHEMVERIGAHLRHLLQVLAEHPQQAIGSLGLLPGDEL---AAWRES 1912 LQ + Y F + R HL+++L + P Q I L L+ G EL + S Sbjct: 393 GLQGKWEYNCDLFTETTIHRFTEHLQNILLGMTSEPSQKISDLPLMSGGELQQIINFGTS 452 Query: 1913 GVNRELHAFDAPVHRLIERQAAATPSAAALLYEDLVLDYRSLNQQANRLAHRLLAEGAGP 1972 N +H + L E+Q A A++ + L Y LN +AN+LA+ L + G P Sbjct: 453 PTNLIIHC----IQELFEQQVAKFGDEIAVICQHQKLTYSELNTKANQLAYHLKSLGVQP 508 Query: 1973 ERIVGVAARRAPEMVVALLAVLKAGAAYLPLDPDLPPARLADMMADSGLSLLLTQTALRA 2032 E VG+ R+ + ++ +LA+LKAG Y+PLDP P RL ++ D+ + ++LTQ Sbjct: 509 EIAVGICVHRSLDFIIGILAILKAGGFYVPLDPTYPQERLEFLIEDAQIQVILTQQQHIP 568 Query: 2033 ELTAPAAVRVLELDAPGQPWAEGMPDHDPGIEVAPDGLAYVIYTSGSTGKPKGAGNRHVS 2092 +L + + D P +P P+ LAYV+YTSGSTG PKG H Sbjct: 569 QL-PDLPIFCFDTDTAN---LTQHPTTNPVNHTTPENLAYVMYTSGSTGVPKGVCIPHRG 624 Query: 2093 LHNRLAWMQEAYPIGPGNTVLQKTPFGFDVSVWEFFWPLMTGARLALAAPDEHRDPAL-- 2150 + RL + ++LQ P FD S +E + L+ G+RL + + ++ P L Sbjct: 625 V-VRLVKDCNYINLSADESILQAAPISFDASTFEIWGALLNGSRLVILS---NQQPTLAE 680 Query: 2151 LAARIRRHAVDTLHFVPSMLQAFV-AHPDSAQCHSLRQVICSGEALPAELQEQAFARLPQ 2209 + I +H + TL + V H +S + S++Q+I G+ L A + P+ Sbjct: 681 IGQAITQHQITTLWLTAGLFHLMVDEHLESLK--SVKQLIAGGDVLSAVHINKLLQTYPE 738 Query: 2210 IALHNLYGPTEAAIDVTHWTCRPG------ERSVPIGRPISHTAAYVLDGGLNPLPHGIA 2263 + N YGPTE T +TC +VPIGRPI++T Y+LD LNPLP G+ Sbjct: 739 CRVINGYGPTEN----TTFTCCYSVTDICESNTVPIGRPINNTQVYILDNHLNPLPVGVP 794 Query: 2264 GELYLGGIGLARGYLGRPGLSAERFVADPFAADG--------SRMYRTGDLVRRRADGEI 2315 GELY+ G GLARGYL +P L+AE+F+ S +Y+TGD R ADG I Sbjct: 795 GELYIAGDGLARGYLNQPTLTAEKFINWGLGTGDWGLGTTTLSTLYKTGDRARYLADGNI 854 Query: 2316 EYLGRTDHQVKIRGLRIELGEIEAQLLAQPGVAAAVVVALVEPGRPARLVGYAADPGGML 2375 EYLGR D+QVKIRG RIELGEIEA L P V VV+A R +L+ Y Sbjct: 855 EYLGRLDNQVKIRGFRIELGEIEAVLNQHPAVKECVVIA-----REKQLIAYFIALDNT- 908 Query: 2376 EAEALRAALLQSLPDYMVPQRLILLPALPLNANGKVDRKALPRPDFNEQGGYEAPQGQTE 2435 + LR L Q LPDY++P + L LPL NGKVDR+ LP P+ + E Sbjct: 909 -PDNLREFLQQRLPDYLIPHFFVALETLPLTVNGKVDRQKLPAPEITSFPDGTVARSDIE 967 Query: 2436 IGLAAIWAEVLRLQRVGRHDNFFELGGDSILSLQIVARAHEQGWPLTPRQLFQSQTVAEL 2495 L IW+ VL L +V +DNFF LGGDSIL++Q++++A++ G LTP+QLFQ QT+AEL Sbjct: 968 AKLLEIWSSVLNLSQVSIYDNFFALGGDSILAIQLISKANQVGLQLTPKQLFQYQTIAEL 1027 Query: 2496 AQQCDQLQPPAPAQAVTAARGRLEDYLSAAQTAQLALQGELEDVYPLSPMQQGMLFHTME 2555 A + + L QG + L+P+Q F E Sbjct: 1028 AG------------------------VFTVDKSSLLPQGMVTGAVQLTPIQ--CWFFEQE 1061 Query: 2556 SPGSGLYVNQLSVRVEG--LDEARFAQAWQSVLARHPVMRTGFLWQAGYAQPLQAVWRTL 2613 + NQ+ G L + +L H ++R F + Q + R + Sbjct: 1062 LVNQH-HFNQVVFLESGEKLQQEVLVAVINKLLLHHDMLRCQFGEKNFITQRRRGAEREI 1120 Query: 2614 AFGIEV--------QDWS--ARADDAELPQAIAAFAAADLARGFDLLQPPLVRATLLRLG 2663 +E+ D S + ++ + Q +A A L G+ PL+R LG Sbjct: 1121 GEVVELGGDVPLVFCDLSGLSGSEQDRVIQEVAGEVQAGLNIGY----APLLRVVHFDLG 1176 Query: 2664 PGQHQLVWTMHHILLDGWSTSALMQELMLAY 2694 L+ +HH+++DG S L+ + AY Sbjct: 1177 EVSRLLI-VIHHLVVDGVSWRILLADFQTAY 1206 Score = 476 bits (1225), Expect = e-133, Method: Compositional matrix adjust. Identities = 335/1065 (31%), Positives = 525/1065 (49%), Gaps = 84/1065 (7%) Query: 2578 FAQAWQSVLARHPVMRTGFLWQAGYAQPLQAVWRTLAFGIEVQDWSARADDAELPQAIAA 2637 Q+ Q ++ RH ++RT F+ G Q + + + I V D S + + + Sbjct: 44 LTQSLQEIIHRHEILRTSFVNVDG--QGIAVIATEINSHIPVVDLSFLPPSQQ-QKLVQE 100 Query: 2638 FAAADLARGFDLLQPPLVRATLLRLGPGQHQLVWTMHHILLDGWSTSALMQELMLAYG-- 2695 A + + F+L PL+RA L L ++ L+ TMHHI+ DGWS + QE+ Y Sbjct: 101 LAQEESQQPFNLEISPLLRAKFLYLNTQEYILLLTMHHIITDGWSINVFAQEMATIYQAF 160 Query: 2696 --GQ--PLPAPGPDYAQYIGWLATLDPQAAQR--YWMGALQALDGPSLLAEGV-RPDPAR 2748 GQ PL YA + W + + + YW L++ P LL P PA Sbjct: 161 SQGQSSPLQPLKIQYADFAVWQRSQSDKFNYQVEYWRQQLES--APELLDLPTDYPRPAI 218 Query: 2749 RGF-GKLYGHCDAAA-TRRLEQFARSQRVTLNTLVQGAWSLALARHKRSTAVAFGATVSG 2806 + F G+ + + T +++Q + TL ++ A+S+ L R+ + + G+ V+ Sbjct: 219 QTFRGQRHSFTISEELTEKIKQLGQETHTTLFMVMFSAFSILLHRYSQQEKIVIGSPVAN 278 Query: 2807 RPAALPGVEKSLGLFINTIPIVVEVDGQRRVGDWLRTLQQTNIDSREHEHTP----LYDI 2862 R PG E +G F+NT +++ ++ V + L +++ + + H+ P + ++ Sbjct: 279 R--HYPGTEGLIGFFVNTFALLISLEDNPTVAELLPRVREMVLSAYSHQDVPFEQVVEEL 336 Query: 2863 QRWSGMAGRALFDSIIVFENFPISRSLEARAQAGLRFGQAEGEGLTGFAMDLQVVARET- 2921 + ++ LF ++ EN P ++ +E GLR+ E +G T D+ ++ ET Sbjct: 337 KLVRSLSHSPLFQVMLAVENAP-TQPIEI---PGLRWSPLEIDGGTA-KFDITLMIAETD 391 Query: 2922 --LDIEFCYDRSLFGDAELEALREQVMLNLDALSASGERALGELARLSPQALAAVLELGR 2979 L ++ Y+ LF + + E + L +++ + + +L +S L ++ G Sbjct: 392 AGLQGKWEYNCDLFTETTIHRFTEHLQNILLGMTSEPSQKISDLPLMSGGELQQIINFGT 451 Query: 2980 GTHDYPADLPAHL---LIARRAALTPDAIALVLEEQSLSYGELNGRANRLAHHLMSLGVG 3036 P +L H L ++ A D IA++ + Q L+Y ELN +AN+LA+HL SLGV Sbjct: 452 S----PTNLIIHCIQELFEQQVAKFGDEIAVICQHQKLTYSELNTKANQLAYHLKSLGVQ 507 Query: 3037 AEQRVGVAVERSFDMVVGLLAVMKAGAAYVPLDLDYPPERLAYMVADSRIQVLLTHARAR 3096 E VG+ V RS D ++G+LA++KAG YVPLD YP ERL +++ D++IQV+LT + Sbjct: 508 PEIAVGICVHRSLDFIIGILAILKAGGFYVPLDPTYPQERLEFLIEDAQIQVILTQQQHI 567 Query: 3097 RLLAAQAQPGLRCLALDDADLAAQLAGLPAHDPVVAVAPQQMAYVIYTSGSTGQPKGVAV 3156 L P L D A L P +PV P+ +AYV+YTSGSTG PKGV + Sbjct: 568 PQL-----PDLPIFCFDTD--TANLTQHPTTNPVNHTTPENLAYVMYTSGSTGVPKGVCI 620 Query: 3157 SHGPLVMHCQATAALYEMTPQWRELQFMSFSFDGAHERWITTLISGAALVLRGPEMWSIE 3216 H +V + + ++ LQ SFD + L++G+ LV+ + ++ Sbjct: 621 PHRGVVRLVKDCNYI-NLSADESILQAAPISFDASTFEIWGALLNGSRLVILSNQQPTLA 679 Query: 3217 QSWQALHQQRVSNAVFPPAYLGQLAQWGEQHGDAPPLELYVFGGEAMPRASFERVRRHLA 3276 + QA+ Q +++ + E ++ + GG+ + ++ + Sbjct: 680 EIGQAITQHQITTLWLTAGLFHLMVD--EHLESLKSVKQLIAGGDVLSAVHINKLLQTYP 737 Query: 3277 PRLLINGYGPTETVVTPLIWKGTSAAGVDFDGPFVPIGKPVGRRNAYILDACLQPVAPGE 3336 +INGYGPTE + T + VPIG+P+ YILD L P+ G Sbjct: 738 ECRVINGYGPTENTTFTCCYSVTDIC----ESNTVPIGRPINNTQVYILDNHLNPLPVGV 793 Query: 3337 AGELYIGGDGLARGYLERPAQSAERFVADPFGEPG--------ARMYRTGDLARWLPDGN 3388 GELYI GDGLARGYL +P +AE+F+ G + +Y+TGD AR+L DGN Sbjct: 794 PGELYIAGDGLARGYLNQPTLTAEKFINWGLGTGDWGLGTTTLSTLYKTGDRARYLADGN 853 Query: 3389 VEYLGRLDHQVKIRGFRIELGEIEALLRRQPGVAEAAVVVRSDGQGEEAVRQLVAYVGAP 3448 +EYLGRLD+QVKIRGFRIELGEIEA+L + P V E V+ R +QL+AY Sbjct: 854 IEYLGRLDNQVKIRGFRIELGEIEAVLNQHPAVKECVVIARE--------KQLIAYF--- 902 Query: 3449 QAVAAPETAQRDFSDSLRAALRAGLPEYMLPAHFVLLAALPVTHNGKLDRKALPAPQAAP 3508 A + D+LR L+ LP+Y++P FV L LP+T NGK+DR+ LPAP+ Sbjct: 903 -------IALDNTPDNLREFLQQRLPDYLIPHFFVALETLPLTVNGKVDRQKLPAPEITS 955 Query: 3509 ARSYVAPATPAAQALAEIWQTVLKRERVGQEDNFFELGGDSLLCLQVIARARGQRQWNFN 3568 + L EIW +VL +V DNFF LGGDS+L +Q+I++A Q Sbjct: 956 FPDGTVARSDIEAKLLEIWSSVLNLSQVSIYDNFFALGGDSILAIQLISKA---NQVGLQ 1012 Query: 3569 FKLADLMQRPTIAALLGLESRLADGPALV--AMNAGPQDVAPLFC 3611 L Q TIA L G+ + D +L+ M G + P+ C Sbjct: 1013 LTPKQLFQYQTIAELAGVFT--VDKSSLLPQGMVTGAVQLTPIQC 1055