BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0087.p (261 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 268 1e-71 PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 233 3e-61 lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 162 9e-40 BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 151 1e-36 CAC3538 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 149 8e-36 CPn0879 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 145 9e-35 BS_yycJ [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 142 8e-34 FN0900 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 140 3e-33 SA0021 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 139 9e-33 CT738 [R] COG1235 Metal-dependent hydrolases of the beta-lactama... 131 2e-30 >RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Rso Ralstonia solanacearum Length = 261 Score = 268 bits (684), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 138/260 (53%), Positives = 176/260 (67%), Gaps = 6/260 (2%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++FASLGSGS+GNALL+ + G ++ T ++LDCGF +RE RR+ RLG P+ + AI Sbjct: 3 VRFASLGSGSDGNALLVESTDG----TTSTRILLDCGFGIRETVRRLERLGCAPASLDAI 58 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVAD--QATDVDVQFCADGQKLAIGDLE 118 +VTHEH DH+ + FA +Y +PVW S+GT++A A A V+FC +IGDL Sbjct: 59 LVTHEHGDHIGSAYAFAAKYSVPVWTSHGTYRATASLRGADRAAVRFCRADDAFSIGDLR 118 Query: 119 LSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLD 178 + PYTVPHDAREP+Q++ DG RRLGVLTDAG T +L L A +LECNHDR+ML Sbjct: 119 ILPYTVPHDAREPLQFIFDDGARRLGVLTDAGMSTEYLCGHLTGLHAFVLECNHDREMLA 178 Query: 179 RSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEG 238 S YP LK+RIGGD+GHLAND +A IL + L V+ AHLS+QNNTPELA AA+ Sbjct: 179 NSAYPWSLKQRIGGDFGHLANDIAAAILARVRHDGLHTVVAAHLSKQNNTPELAAAAIAS 238 Query: 239 VLGTTFGDIGIACQAEGFGW 258 LG GD+ IA Q G GW Sbjct: 239 ALGVPAGDVPIADQEAGLGW 258 >PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Pae Pseudomonas aeruginosa Length = 252 Score = 233 bits (595), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 123/261 (47%), Positives = 165/261 (63%), Gaps = 10/261 (3%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 M+FA LGSGS GN+ L+S SS T +++DCGF LRE +R+ RLGL P+ + AI Sbjct: 1 MRFAVLGSGSRGNSALVS--------SSDTRILIDCGFPLREIIKRLARLGLSPAQLDAI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFCADGQKLAIGDLELS 120 +VTHEH+DH+ GV AR Y+IPV+LS GT + V+ GQ+LAI LE+ Sbjct: 53 LVTHEHADHIHGVELLARHYQIPVYLSAGTLSGMRRPVHPVE--LLRAGQRLAIRGLEVQ 110 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 V HDAREP Q+V DG RR G+LTD G TA +++ A DAL++E NHD ML Sbjct: 111 VVGVSHDAREPTQFVLSDGQRRFGMLTDLGVATAEVLECYRAVDALVVEANHDSTMLAGG 170 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALEGVL 240 PYP FLK R+GG GHL N SAE+++ LD R++ ++ AHLS++NN+P+LAR L Sbjct: 171 PYPYFLKARVGGSRGHLNNHQSAELVKQLDWGRMQHLVLAHLSEKNNSPQLARQTFVDTL 230 Query: 241 GTTFGDIGIACQAEGFGWLDV 261 G G + +A Q G W ++ Sbjct: 231 GCDPGWLQVADQHSGLDWREI 251 >lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Lin Listeria innocua Length = 276 Score = 162 bits (409), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 85/252 (33%), Positives = 147/252 (58%), Gaps = 13/252 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++F+ L SGS GNA L+ GDQ+ +++DCG + ++ E ++G D +D+ AI Sbjct: 15 IRFSILASGSSGNATLVET--GDQK------ILIDCGLSGKKMEGLFAQVGRDMNDLDAI 66 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQA----VADQATDVDVQFCADGQKLAIGD 116 ++THEHSDH+ G+ AR+Y++P++ + TW+A + + +++ QF + K + G Sbjct: 67 LITHEHSDHIKGLGVLARKYKLPIYANAKTWKAMDNMIGEVSSEQKFQFDMETVK-SFGS 125 Query: 117 LELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDM 176 +++ + V HDA EP+ Y+ G+++ ++TD G + + + DA L E NHD +M Sbjct: 126 MQVESFGVSHDAIEPMFYIFHKGNKKFVMITDTGYVSDRMKGHIAGADAYLFESNHDVEM 185 Query: 177 LDRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 L YP +KRRI GD GH++N+ +A + + + K + HLS+ NN ELAR ++ Sbjct: 186 LRMGRYPWNVKRRILGDEGHVSNEDAAIAMSEVITDQTKRIYLGHLSKDNNMKELARMSV 245 Query: 237 EGVLGTTFGDIG 248 L + D+G Sbjct: 246 TQTLISEGIDVG 257 >BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Bha Bacillus halodurans Length = 264 Score = 151 bits (382), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 86/244 (35%), Positives = 132/244 (54%), Gaps = 13/244 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++F+ L SGS GNAL + + +++D G + ++ + ++ DPS ++ I Sbjct: 3 LRFSVLASGSTGNALYVE--------TDKQKLLVDAGLSGKKMDELFQKIDCDPSQLNGI 54 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQ----ATDVDVQFCADGQKLAIGD 116 +VTHEHSDH+ GV AR+Y +P++ + TWQA+ TD F G+ D Sbjct: 55 LVTHEHSDHIKGVGIVARKYNLPIYANAKTWQAMEKALGTLTTDQRFHFEI-GEVKTFAD 113 Query: 117 LELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDM 176 LE+ + V HDA EP+ YV ++L + TD G + + + + D L+ E NHD +M Sbjct: 114 LEVESFGVSHDAAEPMFYVFHHDGKKLVLATDMGYVSERIKKTIENADTLIFEANHDLNM 173 Query: 177 LDRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 L YP +KRRI D GH++N+ +A L + R + + AHLS NN ELAR + Sbjct: 174 LRMGRYPWNVKRRILSDVGHVSNEDAAYALAEVIGDRTERIYLAHLSLDNNMKELARLTV 233 Query: 237 EGVL 240 E VL Sbjct: 234 EQVL 237 >CAC3538 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Cac Clostridium acetobutylicum Length = 261 Score = 149 bits (375), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 85/240 (35%), Positives = 132/240 (55%), Gaps = 14/240 (5%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MKF SL SGS GN++ ++ S + V++D G + + E+ + + DP+++ I Sbjct: 1 MKFCSLYSGSSGNSIFVA--------SDNSKVLIDAGLSGKTIEKALKEIKEDPNEIDGI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVAD---QATDVDVQFCADGQKLAIGDL 117 VTHEHSDH+ GV +R+Y IP++ + TW+A+ + + D +++ + I D+ Sbjct: 53 FVTHEHSDHIKGVGVLSRKYNIPIYANELTWKAMMNSIGKIKDDNIKIITQDY-IEIKDM 111 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDML 177 + Y +PHDA P Y G++ V TD G + + D +LLE NHD +ML Sbjct: 112 NILNYKIPHDAASPCGYKILSGNKSACVATDLGHFADEVKSKISDADVILLESNHDVEML 171 Query: 178 DRSPYPAFLKRRIGGDYGHLAN-DASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 PYP LKRRI + GHL+N D I+ + K + K ++G HLS+ NN PELA + Sbjct: 172 KFGPYPYPLKRRILSEVGHLSNEDCGKAIVDIAKKGKKKIILG-HLSRTNNYPELAYKTV 230 >CPn0879 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Cpn Chlamydophila pneumoniae CWL029 Length = 265 Score = 145 bits (366), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 77/235 (32%), Positives = 127/235 (54%), Gaps = 9/235 (3%) Query: 3 FASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAIVV 62 F L SGS+GN SA G + +++D G + + R +L + +DP D+ AI V Sbjct: 4 FFPLASGSKGN----SAYLG----TDSCKILIDLGVSKQVVTRELLSMNIDPEDIQAIFV 55 Query: 63 THEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQA-TDVDVQFCADGQKLAIGDLELSP 121 THEHSDH+SG+ F + Y P+ + T +A+ + + + + G DLE+ Sbjct: 56 THEHSDHISGIKSFVKAYNTPIVCNLETARALCHLLDSHPEFKIFSTGSSFCFQDLEVQT 115 Query: 122 YTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRSP 181 + VPHDA +P+ ++ + +LG TD G T+ + L CD LL+E NH +++ +S Sbjct: 116 FNVPHDAVDPVAFIFHYREEKLGFCTDLGWVTSWITHELYDCDYLLIESNHSPELVRQSQ 175 Query: 182 YPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAAL 236 P K+R+ GH++N ++L+ + +LK + AHLS + NT ELA + + Sbjct: 176 RPDVYKKRVLSKLGHISNQECGQLLQKIITPKLKKLYLAHLSTECNTAELALSTV 230 >BS_yycJ [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Bsu Bacillus subtilis Length = 268 Score = 142 bits (358), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 79/245 (32%), Positives = 131/245 (53%), Gaps = 11/245 (4%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++F+ L SGS GNA + + ++D G + + + M ++G DV I Sbjct: 3 LQFSVLASGSTGNAFYLE--------TEDHAFLVDAGLSGKAMDGLMAQIGRKLDDVDGI 54 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQ--ATDVDVQFCADGQKL-AIGDL 117 VTHEHSDH+ G+ AR+Y++P++ + TW+A+ +Q D D +F + + + G L Sbjct: 55 FVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFVFPMETVKSFGGL 114 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDML 177 ++ + V HDA EP+ YV R+L ++TD G + + + + + + E NHD ML Sbjct: 115 DVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSANVFVFESNHDVGML 174 Query: 178 DRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALE 237 YP +KRRI D GH++N+ +A + + + AHLSQ NN ELAR +++ Sbjct: 175 QMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAHLSQDNNMKELARMSVQ 234 Query: 238 GVLGT 242 L + Sbjct: 235 QTLAS 239 >FN0900 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Fnu Fusobacterium nucleatum Length = 260 Score = 140 bits (353), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 75/240 (31%), Positives = 134/240 (55%), Gaps = 11/240 (4%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 MK + LGSGS GN+ + +++D GF+ ++ E ++ ++G SD+SAI Sbjct: 1 MKISILGSGSAGNSTFVEI--------EDYKLLVDTGFSCKKTEEKLEKIGKKLSDISAI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQFC--ADGQKLAIGDLE 118 ++THEHSDH++G AR+Y IP++++ +++A A + ++D DG + ++ Sbjct: 53 LITHEHSDHINGAGVIARKYDIPIYITPESYRAGAVKLGEIDKSLLNFIDGDFILNDKVK 112 Query: 119 LSPYTVPHDAREPIQY-VAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDML 177 +SP+ V HDA I + + +R++ + TD G T + + DA+++E N+D + L Sbjct: 113 VSPFDVMHDAERTIGFKLETQLNRKIAISTDIGYITNIVREYFKDVDAMVIESNYDFNTL 172 Query: 178 DRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALE 237 YP LK R+ GHL+N+ A+ ++ + +LK V AH+S+ +N L + LE Sbjct: 173 MNCAYPWNLKERVKSRNGHLSNNECAKFIKEMYTDKLKKVFLAHVSKDSNNISLIKETLE 232 >SA0021 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Sau Staphylococcus aureus N315 Length = 266 Score = 139 bits (349), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 75/244 (30%), Positives = 130/244 (53%), Gaps = 11/244 (4%) Query: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 ++ + L SGS GNA + G ++++D G T ++ E ++ + D++ I Sbjct: 5 IRMSVLASGSTGNATFVENEKG--------SLLVDVGLTGKKMEELFSQIDRNIQDLNGI 56 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAV--ADQATDVDVQFCADG-QKLAIGDL 117 +VTHEH DH+ G+ AR+Y++P++ + TWQA+ D +D +F + + +I Sbjct: 57 LVTHEHIDHIKGLGVLARKYQLPIYANEKTWQAIEKKDSRIPMDQKFIFNPYETKSIAGF 116 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDML 177 ++ + V HDA +P Y+ + ++ +LTD G + + + DA + E NHD DML Sbjct: 117 DVESFNVSHDAIDPQFYIFHNNYKKFTILTDTGYVSDRMKGMIRGSDAFIFESNHDVDML 176 Query: 178 DRSPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELARAALE 237 YP K+RI GD GH++N+ + + + K + +HLSQ NN +LAR ++ Sbjct: 177 RMCRYPWKTKQRILGDMGHVSNEDAGHAMTDVITGNTKRIYLSHLSQDNNMKDLARMSVG 236 Query: 238 GVLG 241 VL Sbjct: 237 QVLN 240 >CT738 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Ctr Chlamydia trachomatis Length = 262 Score = 131 bits (329), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 74/232 (31%), Positives = 121/232 (52%), Gaps = 11/232 (4%) Query: 3 FASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAIVV 62 F + SGS+GN + + +++D G + + + +G+ P D+ I V Sbjct: 4 FFPIASGSKGNCAYLG--------TRSCKLLIDLGISKQAVTEALHSMGIHPEDIQGIFV 55 Query: 63 THEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQATDVDVQF--CADGQKLAIGDLELS 120 THEHSDH++G+ F + YR P+ + T +++ Q D+ F G + ++ DL + Sbjct: 56 THEHSDHIAGLRSFIKTYRTPIICNIETARSL-RQLLDLCPTFKIFTTGHRFSLEDLRVQ 114 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDRS 180 + VPHDA +P+ ++ +LG TD G T+ + L CD LL+E NHD +M+ RS Sbjct: 115 TFNVPHDAVDPVGFIFQYSGMKLGFCTDLGWVTSWITHLLCDCDYLLIESNHDPEMVLRS 174 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKCVIGAHLSQQNNTPELA 232 P K+RI GH++N +L+ + R+K + AHLS + NT E A Sbjct: 175 SRPESCKQRILSKQGHISNAECGALLQHVLTPRIKKIYLAHLSLECNTAEQA 226