BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0057.p (212 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value cynT [P] COG0288 Carbonic anhydrase Eco Escherichia coli K12 328 6e-90 ZcynT [P] COG0288 Carbonic anhydrase EcZ Escherichia coli O157:H... 328 6e-90 ECs0392 [P] COG0288 Carbonic anhydrase Ecs Escherichia coli O157:H7 325 5e-89 PA2053 [P] COG0288 Carbonic anhydrase Pae Pseudomonas aeruginosa 324 1e-88 PA0102 [P] COG0288 Carbonic anhydrase Pae Pseudomonas aeruginosa 230 2e-60 slr1347 [P] COG0288 Carbonic anhydrase Syn Synechocystis 186 5e-47 Cj0237 [P] COG0288 Carbonic anhydrase Cje Campylobacter jejuni 151 1e-36 jhp0004 [P] COG0288 Carbonic anhydrase jHp Helicobacter pylori J99 134 1e-31 AGc4521 [P] COG0288 Carbonic anhydrase Atu Agrobacterium tumefac... 122 4e-28 SMc04083 [P] COG0288 Carbonic anhydrase Sme Sinorhizobium meliloti 120 2e-27 >cynT [P] COG0288 Carbonic anhydrase Eco Escherichia coli K12 Length = 219 Score = 328 bits (840), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 148/206 (71%), Positives = 180/206 (87%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 M++II+GFL+FQ+E FP R+ LFK LAT Q+P+ LFISCSDSR+VPELVTQREPGDLFVI Sbjct: 1 MKEIIDGFLKFQREAFPKREALFKQLATQQSPRTLFISCSDSRLVPELVTQREPGDLFVI 60 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPAVR 120 RNAGNIVPS+GPEPGGVSA+VEYAVA L+VSDIVICGHS+CGAMTA+A+C C+DHMPAV Sbjct: 61 RNAGNIVPSYGPEPGGVSASVEYAVAALRVSDIVICGHSNCGAMTAIASCQCMDHMPAVS 120 Query: 121 NWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHGW 180 +WL + D+AR++NE+RPH+ + MVRENVIAQL N++THPSV +AL +GR+ALHGW Sbjct: 121 HWLRYADSARVVNEARPHSDLPSKAAAMVRENVIAQLANLQTHPSVRLALEEGRIALHGW 180 Query: 181 VYDIESGSILALDAASNRFVPLAQHP 206 VYDIESGSI A D A+ +FVPLA +P Sbjct: 181 VYDIESGSIAAFDGATRQFVPLAANP 206 >ZcynT [P] COG0288 Carbonic anhydrase EcZ Escherichia coli O157:H7 EDL933 Length = 219 Score = 328 bits (840), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 148/206 (71%), Positives = 180/206 (87%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 M++II+GFL+FQ+E FP R+ LFK LAT Q+P+ LFISCSDSR+VPELVTQREPGDLFVI Sbjct: 1 MKEIIDGFLKFQREAFPKREALFKQLATQQSPRTLFISCSDSRLVPELVTQREPGDLFVI 60 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPAVR 120 RNAGNIVPS+GPEPGGVSA+VEYAVA L+VSDIVICGHS+CGAMTA+A+C C+DHMPAV Sbjct: 61 RNAGNIVPSYGPEPGGVSASVEYAVAALRVSDIVICGHSNCGAMTAIASCQCMDHMPAVS 120 Query: 121 NWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHGW 180 +WL + D+AR++NE+RPH+ + MVRENVIAQL N++THPSV +AL +GR+ALHGW Sbjct: 121 HWLRYADSARVVNEARPHSDLPSKAAAMVRENVIAQLANLQTHPSVRLALEEGRIALHGW 180 Query: 181 VYDIESGSILALDAASNRFVPLAQHP 206 VYDIESGSI A D A+ +FVPLA +P Sbjct: 181 VYDIESGSIAAFDGATRQFVPLAANP 206 >ECs0392 [P] COG0288 Carbonic anhydrase Ecs Escherichia coli O157:H7 Length = 219 Score = 325 bits (832), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 147/206 (71%), Positives = 179/206 (86%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 M++II+GFL+FQ+E FP R+ LFK LAT Q+P+ LFISCSDSR+VPELVTQREPGDLF I Sbjct: 1 MKEIIDGFLKFQREAFPKREALFKQLATQQSPRTLFISCSDSRLVPELVTQREPGDLFGI 60 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPAVR 120 RNAGNIVPS+GPEPGGVSA+VEYAVA L+VSDIVICGHS+CGAMTA+A+C C+DHMPAV Sbjct: 61 RNAGNIVPSYGPEPGGVSASVEYAVAALRVSDIVICGHSNCGAMTAIASCQCMDHMPAVS 120 Query: 121 NWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHGW 180 +WL + D+AR++NE+RPH+ + MVRENVIAQL N++THPSV +AL +GR+ALHGW Sbjct: 121 HWLRYADSARVVNEARPHSDLPSKAAAMVRENVIAQLANLQTHPSVRLALEEGRIALHGW 180 Query: 181 VYDIESGSILALDAASNRFVPLAQHP 206 VYDIESGSI A D A+ +FVPLA +P Sbjct: 181 VYDIESGSIAAFDGATRQFVPLAANP 206 >PA2053 [P] COG0288 Carbonic anhydrase Pae Pseudomonas aeruginosa Length = 220 Score = 324 bits (830), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 149/206 (72%), Positives = 175/206 (84%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 MRDII+GFLRFQ++ +P+R +LFK+LAT Q PKALFI+CSDSR+VPEL+TQREPG+LFVI Sbjct: 1 MRDIIDGFLRFQRDAYPARSQLFKSLATRQAPKALFIACSDSRVVPELLTQREPGELFVI 60 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPAVR 120 RNAGNIVP +GP+PGGVSA+VEYAVA L V DIV+CGHSDCGAM A+A+CACLD +PAV Sbjct: 61 RNAGNIVPGYGPQPGGVSASVEYAVAVLGVGDIVVCGHSDCGAMGAIASCACLDQLPAVA 120 Query: 121 NWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHGW 180 WLHH +AAR +N + HA+E R+D +VR NVIAQL N+RTHP VA AL QGRL LHGW Sbjct: 121 GWLHHAEAARAMNSAHEHASEAARLDALVRHNVIAQLANLRTHPCVARALEQGRLNLHGW 180 Query: 181 VYDIESGSILALDAASNRFVPLAQHP 206 VYDIESG I ALD AS RFV LA+HP Sbjct: 181 VYDIESGRIDALDGASRRFVSLAEHP 206 >PA0102 [P] COG0288 Carbonic anhydrase Pae Pseudomonas aeruginosa Length = 242 Score = 230 bits (587), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 109/208 (52%), Positives = 145/208 (69%), Gaps = 2/208 (0%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 ++ I++GF F++EVFP ++ LFK LA Q P+A+FI+C+DSR+VPEL+TQ PGDLFV Sbjct: 22 LKRIVDGFQHFRREVFPEQQALFKKLANSQRPRAMFITCADSRIVPELITQSSPGDLFVT 81 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPAVR 120 RN GN+VP +G GGVS +EYAV L V I++CGHSDCGAM AV L+ MP V+ Sbjct: 82 RNVGNVVPPYGQMNGGVSTAIEYAVLALGVHHIIVCGHSDCGAMRAVLDPQTLERMPTVK 141 Query: 121 NWLHHTDAAR-MINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHG 179 WL H + AR ++ ++ D + + ENV+AQL+++RTHPSVA LA G+L +HG Sbjct: 142 AWLRHAEVARTVVADNCDCGASHDTLGVLTEENVVAQLDHLRTHPSVASRLASGQLFIHG 201 Query: 180 WVYDIESGSILALDAASNRFVPL-AQHP 206 WVYDIES I A DA RF+PL +HP Sbjct: 202 WVYDIESAQIRAYDAKQGRFLPLDGEHP 229 >slr1347 [P] COG0288 Carbonic anhydrase Syn Synechocystis Length = 311 Score = 186 bits (471), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 95/215 (44%), Positives = 141/215 (65%), Gaps = 3/215 (1%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 M+ +I G +F++ F S ++LF+ L+ GQ P+ LFI CSDSR+ P L+TQ E GDLFVI Sbjct: 38 MQRLIEGLQKFREGYFSSHRDLFEQLSHGQHPRILFICCSDSRVDPNLITQSEVGDLFVI 97 Query: 61 RNAGNIVPSFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACL-DHMPAV 119 RNAGNI+P +G GG A +EYA+ L+++ I++CGHS CGAM + L + +P V Sbjct: 98 RNAGNIIPPYGAANGGEGAAMEYALVALEINQIIVCGHSHCGAMKGLLKLNSLQEKLPLV 157 Query: 120 RNWLHHTDAA-RMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALH 178 +WL HT+A R++ ++ H +D I+ V EN++ QL N++T+P++ L +G L+LH Sbjct: 158 YDWLKHTEATRRLVLDNYSHLEGEDLIEVAVAENILTQLKNLQTYPAIHSRLHRGDLSLH 217 Query: 179 GWVYDIESGSILALDAASNRFV-PLAQHPAASSED 212 GW+Y IE G +LA D + FV P ++ A ED Sbjct: 218 GWIYRIEEGEVLAYDGVLHDFVAPQSRINALEPED 252 >Cj0237 [P] COG0288 Carbonic anhydrase Cje Campylobacter jejuni Length = 211 Score = 151 bits (381), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 81/210 (38%), Positives = 116/210 (55%), Gaps = 19/210 (9%) Query: 1 MRDIINGFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVI 60 M ++I+G ++F QE F +ELF++L Q P LFI CSDSR++P L+T PG+LFVI Sbjct: 1 MENLISGAIKFMQEDFKEHEELFESLKNKQNPHTLFIGCSDSRVIPNLITNTGPGELFVI 60 Query: 61 RNAGNIVPSF--GPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATC-ACLDHMP 117 RN NIVP + G + ++ +EYA+ L + +IV+CGHS+CG A+ L+ +P Sbjct: 61 RNIANIVPPYRVGEDYLATTSAIEYALNSLHIKNIVVCGHSNCGGCNALYYSDEELNKIP 120 Query: 118 AVRNWLHHTDA--------ARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVA 169 V+ WL D AR R TEK N++ L NI T+P V A Sbjct: 121 NVKKWLTMLDPIKKDVMIFARDDLAMRSWLTEK--------LNLVNSLQNILTYPGVQEA 172 Query: 170 LAQGRLALHGWVYDIESGSILALDAASNRF 199 L +G++ +H W Y IE+G I D + F Sbjct: 173 LDEGKIEVHAWYYIIETGEIYEYDFKAKIF 202 >jhp0004 [P] COG0288 Carbonic anhydrase jHp Helicobacter pylori J99 Length = 221 Score = 134 bits (338), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 72/205 (35%), Positives = 111/205 (54%), Gaps = 7/205 (3%) Query: 7 GFLRFQQEVFPSRKELFKTLATGQTPKALFISCSDSRMVPELVTQREPGDLFVIRNAGNI 66 G L FQ+ + KEL+++L T Q P LFISC DSR+VP L+T +PG+L+VIRN GN+ Sbjct: 6 GALEFQENEYEEFKELYESLKTKQKPHTLFISCVDSRVVPNLITGTQPGELYVIRNMGNV 65 Query: 67 VP--SFGPEPGGVSATVEYAVAQLKVSDIVICGHSDCGAMTAVATC---ACLDHMPAVRN 121 +P + E A+VEYA+A + V +++ICGHSDCGA ++ P + N Sbjct: 66 IPPKTSYKESLSTIASVEYAIAHVGVQNLIICGHSDCGACGSIHLIHDETTKAKTPYIAN 125 Query: 122 WLHHTDAARMINESRPHATEK--DRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLALHG 179 W+ + + ++ P + R R N QLNN+ ++ + + L + G Sbjct: 126 WIQFLEPIKEELKNHPQFSNHFAKRSWLTERLNARLQLNNLLSYDFIQERVINNELKIFG 185 Query: 180 WVYDIESGSILALDAASNRFVPLAQ 204 W Y IE+G I + S+ F P+ + Sbjct: 186 WHYIIETGRIYNYNFESHFFEPIEE 210 >AGc4521 [P] COG0288 Carbonic anhydrase Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 213 Score = 122 bits (307), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 70/203 (34%), Positives = 105/203 (51%), Gaps = 9/203 (4%) Query: 4 IINGFLRFQQEVFPSRKELFKTLA-TGQTPKALFISCSDSRMVPELVTQREPGDLFVIRN 62 ++NG+ F + +E ++ LA TGQ P+ LFI+C DSR PE + PG+LFV+RN Sbjct: 8 LLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPGELFVVRN 67 Query: 63 AGNIVPSFGPEPGG----VSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPA 118 N+VP F EP G SA +EYAV LKV DIV+ GH CG + A P Sbjct: 68 VANMVPPF--EPDGQYHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLEPLSPG 125 Query: 119 --VRNWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLA 176 + W++ +A +S T +R + R ++ + N+R P V G++ Sbjct: 126 DFIGKWMNMVKSAAEQIQSNDVMTASERQTALERVSIRNSIANLRGFPFVKAQETAGKVK 185 Query: 177 LHGWVYDIESGSILALDAASNRF 199 LHG +DI +G + +D+ + F Sbjct: 186 LHGAWFDISTGELWVMDSKTGDF 208 >SMc04083 [P] COG0288 Carbonic anhydrase Sme Sinorhizobium meliloti Length = 227 Score = 120 bits (302), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 67/203 (33%), Positives = 110/203 (54%), Gaps = 9/203 (4%) Query: 4 IINGFLRFQQEVFPSRKELFKTLA-TGQTPKALFISCSDSRMVPELVTQREPGDLFVIRN 62 ++ G+ F F +++ +KTLA +GQ PK + I+C DSR PE + PG+LFV+RN Sbjct: 22 LLTGYRNFMSGRFNEQQQRYKTLAESGQKPKTMVIACCDSRAAPETIFDSGPGELFVVRN 81 Query: 63 AGNIVPSFGPEPGG----VSATVEYAVAQLKVSDIVICGHSDCGAMTAVATCACLDHMPA 118 N++P + EP G SA +E+AV L+V++IV+ GH CG + A P Sbjct: 82 VANMMPPY--EPDGHYHSTSAALEFAVQSLRVTNIVVMGHGRCGGIKAALDPDAEPLSPG 139 Query: 119 --VRNWLHHTDAARMINESRPHATEKDRIDGMVRENVIAQLNNIRTHPSVAVALAQGRLA 176 + W++ A +S T+ +R + R ++ + N+RT P V + ++G+L Sbjct: 140 DFIGRWMNLLKPAAEQIQSNDVMTQAERQRALERVSIRNSIANLRTFPCVNILESKGKLR 199 Query: 177 LHGWVYDIESGSILALDAASNRF 199 LHG +DI +G + +DA + F Sbjct: 200 LHGAWFDISTGELWVMDAKTGDF 222