BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0013.0052.p (254 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2554 [IQR] COG1028 Dehydrogenases with different specificities... 305 6e-83 RSc2534 [IQR] COG1028 Dehydrogenases with different specificitie... 302 4e-82 BMEII0816 [IQR] COG1028 Dehydrogenases with different specificit... 301 6e-82 SMa1452 [IQR] COG1028 Dehydrogenases with different specificitie... 298 9e-81 mlr2803 [IQR] COG1028 Dehydrogenases with different specificitie... 254 2e-67 Rv1144 [IQR] COG1028 Dehydrogenases with different specificities... 246 4e-65 MT1177 [IQR] COG1028 Dehydrogenases with different specificities... 246 4e-65 AGc2613 [IQR] COG1028 Dehydrogenases with different specificitie... 238 7e-63 CC0124 [IQR] COG1028 Dehydrogenases with different specificities... 186 4e-47 PA4389 [IQR] COG1028 Dehydrogenases with different specificities... 141 1e-33 >PA2554 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 255 Score = 305 bits (781), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 157/255 (61%), Positives = 197/255 (77%), Gaps = 1/255 (0%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M ++ V++VTG +SGLGAATA+ L+ G KVVLAD+N AG A LGA ARFV D+ Sbjct: 1 MRIENRVFLVTGGSSGLGAATAKMLVEQGGKVVLADINAEAGAAKAAELGAQARFVRADI 60 Query: 61 TSETSAQEVLGVA-SSMGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFN 119 SE ++ + A + G + GL NCAG+AP EK+LG+ G+H L+SF R ++INLVGSFN Sbjct: 61 ASEADGRQAVAAALEAFGGLHGLANCAGVAPAEKVLGRNGIHALESFRRVIDINLVGSFN 120 Query: 120 MARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELA 179 M RLAA+ +S G D GERGVI++TAS+AAFDGQ+GQ AY+ASK GVV MTLP+ARELA Sbjct: 121 MLRLAAEAMSQGQPDEGGERGVIVNTASVAAFDGQIGQAAYSASKSGVVGMTLPIARELA 180 Query: 180 RHGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLN 239 R GIRV+TIAPGI ETPMM GMP+EV +SL +VPFPPRLG+P E+A LV I+EN LN Sbjct: 181 RFGIRVMTIAPGIFETPMMAGMPQEVRDSLGASVPFPPRLGRPDEYAALVRQIIENSMLN 240 Query: 240 GEVIRMDGALRMSAK 254 GEVIR+DGA+RM+A+ Sbjct: 241 GEVIRLDGAIRMAAR 255 >RSc2534 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 252 Score = 302 bits (774), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 151/254 (59%), Positives = 189/254 (74%), Gaps = 2/254 (0%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M ++ V++VTG ASGLGA T L G KVV+AD+N AG + +G RFV DV Sbjct: 1 MEIRDQVFIVTGGASGLGAGTTRALAEAGGKVVIADLNEAAGAALAQEIGG--RFVRCDV 58 Query: 61 TSETSAQEVLGVASSMGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFNM 120 +SE Q + A+S+GA+ GLVNCAGIAP + +GK G H LD F R +NINL+G+FNM Sbjct: 59 SSEADGQAAVQAATSLGALAGLVNCAGIAPASRTVGKAGPHPLDQFARVININLIGTFNM 118 Query: 121 ARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELAR 180 RLAA ++A +A GERGVII+TAS+AAFDGQ+GQ AYAASKGGVV+MTL +AR+L+R Sbjct: 119 IRLAATAMTANAPNAGGERGVIINTASVAAFDGQIGQAAYAASKGGVVAMTLAIARDLSR 178 Query: 181 HGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNG 240 GIRV+TIAPGI ETPM+LGMP EV ++L + VPFPPRLGKP+E+A L I+EN LNG Sbjct: 179 DGIRVMTIAPGIFETPMLLGMPPEVQDALGKMVPFPPRLGKPAEYAQLARAIIENPMLNG 238 Query: 241 EVIRMDGALRMSAK 254 E IR+DGA+RM K Sbjct: 239 ETIRLDGAIRMQPK 252 >BMEII0816 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bme Brucella melitensis Length = 255 Score = 301 bits (772), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 153/255 (60%), Positives = 199/255 (78%), Gaps = 1/255 (0%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M ++ V+++TGA SGLGAA ++ + GAKVVL DVN AGE LGA+ARF TDV Sbjct: 1 MQIENRVFLITGAGSGLGAAVSKMAVEAGAKVVLLDVNAEAGEAGAKALGASARFQRTDV 60 Query: 61 TSETSAQEVLGVASSMGAVVG-LVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFN 119 S+T + + A + + LVNCAG+APGEK+LG+ G H+L++F R ++INL+G+FN Sbjct: 61 ASDTDGKAAIAAAIEAFSRIDVLVNCAGVAPGEKVLGREGAHKLETFTRTISINLIGTFN 120 Query: 120 MARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELA 179 M RLAA+ ++ GERGVII+TAS+AAFDGQ+GQ AY+ASKGGV +MTLP+ARELA Sbjct: 121 MLRLAAEAMAKNEPGQGGERGVIINTASVAAFDGQIGQAAYSASKGGVAAMTLPVARELA 180 Query: 180 RHGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLN 239 RHGIRV+TIAPGI +TPMM GMP+EV ++L +VPFPPRLG+P+E+A LV HI+EN+ LN Sbjct: 181 RHGIRVMTIAPGIFKTPMMAGMPQEVQDALGASVPFPPRLGEPAEYAALVRHIVENQMLN 240 Query: 240 GEVIRMDGALRMSAK 254 GEVIR+DGALRM+AK Sbjct: 241 GEVIRLDGALRMAAK 255 >SMa1452 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 255 Score = 298 bits (762), Expect = 9e-81, Method: Compositional matrix adjust. Identities = 157/255 (61%), Positives = 191/255 (74%), Gaps = 1/255 (0%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M +K V++VTGA+SGLGAA L + GA V+ D+ P AGE+ A LGA RF DV Sbjct: 1 MQLKSRVFIVTGASSGLGAAVTRMLAQEGATVLGLDLKPPAGEEPAAELGAAVRFRNADV 60 Query: 61 TSETSAQEVLGVASS-MGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFN 119 T+E A L A G V GLVNCAG APGEK+LG+ G H LDSF R + +NL+G+FN Sbjct: 61 TNEADATAALAFAKQEFGHVHGLVNCAGTAPGEKILGRSGPHALDSFARTVAVNLIGTFN 120 Query: 120 MARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELA 179 M RLAA+ +S G DA GERGVI++TASIAAFDGQ+GQ AYAASKGGV ++TLP ARELA Sbjct: 121 MIRLAAEVMSQGEPDADGERGVIVNTASIAAFDGQIGQAAYAASKGGVAALTLPAARELA 180 Query: 180 RHGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLN 239 R GIRVVTIAPGI +TPMM GMP++V ++L+ +VPFPPRLG+ E+A LV HI EN LN Sbjct: 181 RFGIRVVTIAPGIFDTPMMAGMPQDVQDALAASVPFPPRLGRAEEYAALVKHICENTMLN 240 Query: 240 GEVIRMDGALRMSAK 254 GEVIR+DGALRM+ + Sbjct: 241 GEVIRLDGALRMAPR 255 >mlr2803 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 253 Score = 254 bits (648), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 136/249 (54%), Positives = 173/249 (69%), Gaps = 3/249 (1%) Query: 7 VYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDVTSETSA 66 + +VTG SGLG ATA L GA+V + DV K+ A +G + V DV+S S Sbjct: 7 IAIVTGGGSGLGEATARALAAKGARVAIFDVGIERAAKVAADIGGIS--VQCDVSSADSG 64 Query: 67 QEVLG-VASSMGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFNMARLAA 125 L AS +G LVNCAGIA G K +GK G H LD + + + +NL+G+FNM RL A Sbjct: 65 TAALAETASKLGEPRILVNCAGIAIGVKTIGKDGPHPLDQYRKVIEVNLIGTFNMIRLVA 124 Query: 126 QHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELARHGIRV 185 ++ GERGVI++TAS+AA+DGQ+GQ AY+ASKGGVV MTLP+AR+LAR GIRV Sbjct: 125 DRAASLEPLQGGERGVIVNTASVAAYDGQIGQAAYSASKGGVVGMTLPVARDLARSGIRV 184 Query: 186 VTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNGEVIRM 245 TIAPGI +TPMM GMP+EV +SL VPFP RLG+PSE+A L +HI+EN+ LNGE IR+ Sbjct: 185 CTIAPGIFKTPMMAGMPQEVQDSLGAAVPFPSRLGEPSEYAALALHIIENQMLNGETIRL 244 Query: 246 DGALRMSAK 254 DGA+RM+ K Sbjct: 245 DGAIRMAPK 253 >Rv1144 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mtu Mycobacterium tuberculosis H37Rv Length = 250 Score = 246 bits (628), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 132/254 (51%), Positives = 173/254 (68%), Gaps = 4/254 (1%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M K V VVTG ASGLG AT ++L+ GA+VV+ D+ G+ + LG ARF DV Sbjct: 1 MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLR---GDDVVGGLGDRARFAQADV 57 Query: 61 TSETSAQEVLGVASSMGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFNM 120 T E + L +A S+G V +VNCAG ++L + GV L +F + ++INLVG+FN+ Sbjct: 58 TDEAAVSNALELADSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAAFRKIVDINLVGTFNV 117 Query: 121 ARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELAR 180 RL A+ I A ERGVII+TAS+AAFDGQ+GQ AY+ASKGGVV MTLP+AR+LA Sbjct: 118 LRLGAERI-AKTEPIGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLAS 176 Query: 181 HGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNG 240 IRVVTIAPG+ +TP++ +P E SL + VP P RLG P E+ LV+HI+EN LNG Sbjct: 177 KLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALVLHIIENPMLNG 236 Query: 241 EVIRMDGALRMSAK 254 EVIR+DGA+RM+ + Sbjct: 237 EVIRLDGAIRMAPR 250 >MT1177 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MtC Mycobacterium tuberculosis CDC1551 Length = 250 Score = 246 bits (628), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 132/254 (51%), Positives = 173/254 (68%), Gaps = 4/254 (1%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDV 60 M K V VVTG ASGLG AT ++L+ GA+VV+ D+ G+ + LG ARF DV Sbjct: 1 MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLR---GDDVVGGLGDRARFAQADV 57 Query: 61 TSETSAQEVLGVASSMGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFNM 120 T E + L +A S+G V +VNCAG ++L + GV L +F + ++INLVG+FN+ Sbjct: 58 TDEAAVSNALELADSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAAFRKIVDINLVGTFNV 117 Query: 121 ARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELAR 180 RL A+ I A ERGVII+TAS+AAFDGQ+GQ AY+ASKGGVV MTLP+AR+LA Sbjct: 118 LRLGAERI-AKTEPIGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLAS 176 Query: 181 HGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNG 240 IRVVTIAPG+ +TP++ +P E SL + VP P RLG P E+ LV+HI+EN LNG Sbjct: 177 KLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALVLHIIENPMLNG 236 Query: 241 EVIRMDGALRMSAK 254 EVIR+DGA+RM+ + Sbjct: 237 EVIRLDGAIRMAPR 250 >AGc2613 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 257 Score = 238 bits (608), Expect = 7e-63, Method: Compositional matrix adjust. Identities = 131/251 (52%), Positives = 173/251 (68%), Gaps = 7/251 (2%) Query: 9 VVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDVTSETSAQE 68 +VTGAASGLGAA A L GA V + D N AG+K+ A +G A V DVTS+ AQ Sbjct: 9 LVTGAASGLGAAVARMLAARGAAVTIFDRNGEAGKKLAAEIGGKA--VQGDVTSDADAQA 66 Query: 69 VLGVASS-MGAVVGLVNCAGIAPGEKLLGKGGVHRLDSFMRALNINLVGSFNMARLAAQH 127 + VA+S G + LVNCAGI ++LG+ G L F + + +NL+G+FNM RLAA H Sbjct: 67 AIKVAASAKGGLRILVNCAGIGTAGRILGREGPQPLGDFEQVIRVNLIGTFNMMRLAAAH 126 Query: 128 ISAGPAD----AAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELARHGI 183 ++ D + + GVI++TAS+AAF+GQ+GQ AYAASKGG+VS+ LP ARELAR I Sbjct: 127 MAEREQDEGQDSRQDNGVIVNTASVAAFEGQIGQAAYAASKGGIVSLALPAARELARFRI 186 Query: 184 RVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNGEVI 243 RV T+APGI TP++ G+P+EV ESL+ +P P RLG P+EFA V ++EN Y+NGEVI Sbjct: 187 RVNTVAPGIFLTPLLQGLPQEVQESLAGQIPHPSRLGDPAEFADTVRFLIENDYMNGEVI 246 Query: 244 RMDGALRMSAK 254 R+DGA+RM + Sbjct: 247 RLDGAIRMQPR 257 >CC0124 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 260 Score = 186 bits (472), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 117/254 (46%), Positives = 152/254 (59%), Gaps = 11/254 (4%) Query: 9 VVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATLGANARFVLTDVTSETSAQE 68 VVTG ASGLG ATA L G KV L D+N G ++ +G F +VTS+ Sbjct: 10 VVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGG--VFCKVNVTSDADVDA 67 Query: 69 VLGVA-SSMGAVVGLVNCAGI------APGEKLLGKGGVHRLDSFMRALNINLVGSFN-M 120 A ++ G LVNCAG A +K G+ LD+F R + INLVG+F + Sbjct: 68 GFEKARAAHGQERILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINLVGTFRCI 127 Query: 121 ARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTLPMARELAR 180 A+ A + P + GERG I++TAS+AA DGQMGQ AY+ASKGGVV MTLP+AR+L Sbjct: 128 AKSAKGMLDLEPLED-GERGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLPIARDLMG 186 Query: 181 HGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHILENRYLNG 240 GIRV TI PGI TP+M PE V L+ +VPFP RLG P E+A L + ++ Y NG Sbjct: 187 EGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMITCGYFNG 246 Query: 241 EVIRMDGALRMSAK 254 E +R+DG +RM+ + Sbjct: 247 EDVRLDGGIRMAPR 260 >PA4389 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 252 Score = 141 bits (355), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 98/259 (37%), Positives = 140/259 (54%), Gaps = 15/259 (5%) Query: 1 MAVKQGVYVVTGAASGLGAATAEQLIRGGAKVVLADVNPVAGEKMQATL---GANARFVL 57 M +K V ++TG GLG A E L GA++ L D+N ++ A G +AR + Sbjct: 1 MQLKDKVIIITGGCQGLGRAMGEYLAGKGARLALVDLNRERLDEAVAACKAAGGDARAYV 60 Query: 58 TDVTSETSAQEVLG-VASSMGAVVGLVNCAGI-APGEKLLGKGG---VHRLDSFMRALNI 112 +V E ++ VAS GA+ GLVN AGI G + K G L + +++ Sbjct: 61 CNVADEEQVTHMVAQVASDFGAINGLVNNAGILRDGLTIKVKDGQLSKMSLAQWQSVIDV 120 Query: 113 NLVGSFNMARLAAQHISAGPADAAGERGVIIHTASIAAFDGQMGQVAYAASKGGVVSMTL 172 NL G F L + ++A + E G I++ +SI+ G MGQ Y+A+K GV + T+ Sbjct: 121 NLTGVF----LCTREVAAKMIELKNE-GAIVNISSISRA-GNMGQANYSAAKAGVAADTV 174 Query: 173 PMARELARHGIRVVTIAPGIIETPMMLGMPEEVLESLSRNVPFPPRLGKPSEFAGLVMHI 232 A+ELAR+GIRV +APG IET M GM E LE ++ +P R+GKP E A V +I Sbjct: 175 VWAKELARYGIRVAGVAPGFIETEMTAGMKPEALEKMTAGIPL-KRMGKPVEIAHSVAYI 233 Query: 233 LENRYLNGEVIRMDGALRM 251 EN Y G V+ +DG LR+ Sbjct: 234 FENDYYTGRVLELDGGLRL 252