BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0077.p (405 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4117 [T] COG4251 Bacteriophytochrome (light-regulated signal t... 110 5e-24 BS_resE_4 [T] COG0642 Signal transduction histidine kinase Bsu B... 109 1e-23 BH1809 [T] COG0642 Signal transduction histidine kinase Bha Baci... 98 4e-20 all0182_2 [T] COG0642 Signal transduction histidine kinase Nos N... 96 2e-19 VC0622_1 [T] COG0642 Signal transduction histidine kinase Vch Vi... 95 2e-19 CAC0437 [T] COG0642 Signal transduction histidine kinase Cac Clo... 95 4e-19 BH1581 [T] COG0642 Signal transduction histidine kinase Bha Baci... 91 3e-18 alr1171 [T] COG0642 Signal transduction histidine kinase Nos Nos... 91 5e-18 lin0316 [T] COG5002 Signal transduction histidine kinase Lin Lis... 91 5e-18 all0978_3 [T] COG0642 Signal transduction histidine kinase Nos N... 90 9e-18 >PA4117 [T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase) Pae Pseudomonas aeruginosa Length = 728 Score = 110 bits (276), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 71/241 (29%), Positives = 117/241 (48%), Gaps = 11/241 (4%) Query: 142 LAESLARYTKLLDQSRNLFLAILGHDLRNPLGATIHGAQIMLLAEDIDDRHRKIAARIYN 201 L E + +D+ R +A+LGHDLRNPL + A ++ D R ++ I Sbjct: 489 LMELCLNHAAEVDRMRQRLIAVLGHDLRNPLQSISMAAALL---SSSDTRTTELRQHISA 545 Query: 202 SGQRMSKLVADLLDYTRTHLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLKTSGE 261 S RM +LV+ +LD +R G GL + +V + ++++ E ++P VI + + Sbjct: 546 SSSRMERLVSQILDMSRLQSGIGLTVNPVDTDVSQLVRQIVCETDVAYPGLVIEIAIDPQ 605 Query: 262 LNGEWDKERIAQAISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHT 321 + D +R AQ +NLL NA HG G + V ++ EV +++ N + E +L Sbjct: 606 VRAVVDPDRYAQVAANLLSNARHHGLPGRPVLVTLTRQGDEVCLSVLNETSGLSEAQLAN 665 Query: 322 IFDPLVRLVANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRL 381 +F+P R E + G +G+GLYI + +A AH G + + TF +RL Sbjct: 666 LFEPFKR------ESADNQRNRNG-LGIGLYISQAIAQAHQGRIDVDCRD-DVITFCLRL 717 Query: 382 P 382 P Sbjct: 718 P 718 >BS_resE_4 [T] COG0642 Signal transduction histidine kinase Bsu Bacillus subtilis Length = 269 Score = 109 bits (272), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 75/236 (31%), Positives = 126/236 (53%), Gaps = 16/236 (6%) Query: 153 LDQSRNLFLAILGHDLRNPLGATIHGAQIML--LAEDIDDRHRKIAARIYNSGQRMSKLV 210 LD+ R F+A + H+LR P+ ++ ++ +A +DR ++IA IY+ RM +LV Sbjct: 41 LDKLREDFIANVSHELRTPISMLQGYSEAIVDDIASSEEDR-KEIAQIIYDESLRMGRLV 99 Query: 211 ADLLDYTRTHLG-SGLPLEISSANVGDIAQRVIDEISTSHPDKVITLKTSGELNGE---W 266 DLLD R G +GL E NV + +++I + S +K I L L E + Sbjct: 100 NDLLDLARMESGHTGLHYE--KINVNEFLEKIIRKFSGVAKEKNIALDHDISLTEEEFMF 157 Query: 267 DKERIAQAISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFDPL 326 D++++ Q +NL+ NA++H + G ++ + + + + + + I + G IPEE L IF+ Sbjct: 158 DEDKMEQVFTNLIDNALRHTSAGGSVSISVHSVKDGLKIDIKDSGSGIPEEDLPFIFERF 217 Query: 327 VRLVANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRLP 382 + R G+ G+ GLGL IV+ + AH GS+T S +GTTF+ +P Sbjct: 218 YKADKARTR------GRAGT-GLGLAIVKNIVEAHNGSITVHSRIDKGTTFSFYIP 266 >BH1809 [T] COG0642 Signal transduction histidine kinase Bha Bacillus halodurans Length = 351 Score = 97.8 bits (242), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 77/271 (28%), Positives = 132/271 (48%), Gaps = 26/271 (9%) Query: 121 KEGYETNVDDITRFNEAIDQALAESLARYTKLLDQSRNLFLAILGHDLRNPLGATIHGAQ 180 K+ ++ DI + ++ + QA+A + S++ + L HDLR PL + I Sbjct: 97 KDEFKNIAHDINQASKNLQQAIARG-----DFSESSKDQLVVNLAHDLRTPLTSVIGYLD 151 Query: 181 IMLLAEDIDD---RHRKIAARIYNSGQRMSKLVADLLDYTRTHLGSGLPLEISSANVGDI 237 ++L +D+ + RH + A + QR+ +L+ +L + TR + G LP+ + ++ D+ Sbjct: 152 LILKEKDLTEEQVRHFLMIA--FTKSQRLERLIDELFEITRMNYGM-LPVNKKNIDLSDL 208 Query: 238 AQRVIDEI----STSHPDKVITLKTSGELNGEWDKERIAQAISNLLGNAVQHGATGEAIK 293 ++ +E+ +H +KT + G D E +A+ NLL NA ++G G+ I Sbjct: 209 LLQLKEELYPLFEKNHLIARTNMKTPLPILG--DGELLARVFENLLTNANRYGYDGKFID 266 Query: 294 VEISASRGEVHVAINNRGPLIPEEKLHTIFDPLVRLVANRGEGGGEGSGQGGSMGLGLYI 353 + EV + I N G IP ++L +FD G + + S GLGL+I Sbjct: 267 INGFIDSEEVVIQIVNYGDQIPPDELPHVFDMFYT--------GDKARTKDDSTGLGLFI 318 Query: 354 VREVASAHGGSVTASSSTAEGTTFTIRLPRD 384 + + HGG+VTA SS T F +RLP D Sbjct: 319 AKNIVEQHGGTVTADSSLIR-TVFEVRLPED 348 >all0182_2 [T] COG0642 Signal transduction histidine kinase Nos Nostoc sp. PCC 7120 Length = 251 Score = 95.5 bits (236), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 18/233 (7%) Query: 160 FLAILGHDLRNPLGATIHGAQIMLLAEDID-DRHRKIAARIYNSGQRMSKLVADLLDYTR 218 FLA+L H+LR PL A I G +L +D R + A I + +L+ DLLD +R Sbjct: 5 FLAVLSHELRTPLNA-ILGWSKLLQERKLDPTRTFQALATIERNATLQVQLIEDLLDISR 63 Query: 219 THLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLKTS-----GELNGEWDKERIAQ 273 G L + I+ N+ + ++ + + K+I + T+ G++ G D R+ Q Sbjct: 64 ILQGK-LVINITKVNLVTVILAALETMRLAAESKLIQVLTNFPPNIGQVMG--DSARLQQ 120 Query: 274 AISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFDPLVRLVANR 333 + NLL NAV+ G I+V + G + +++ G I E L +FD Sbjct: 121 VVWNLLSNAVKFTPNGGKIEVTLDKMEGYAQIVVSDTGKGIQPEFLPYVFDYF------- 173 Query: 334 GEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAE-GTTFTIRLPRDP 385 + + + G +GLGL IVR++ HGG+VTA S E G +FT+RLP P Sbjct: 174 RQADSSSTRRFGGLGLGLAIVRKIVEIHGGTVTAQSLGEEQGASFTVRLPILP 226 >VC0622_1 [T] COG0642 Signal transduction histidine kinase Vch Vibrio cholerae Length = 769 Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 76/241 (31%), Positives = 128/241 (53%), Gaps = 22/241 (9%) Query: 151 KLLDQSRNLFLAILGHDLRNPLGATIHGAQIMLLAED--IDDRHRKIAARIYNSGQRMSK 208 +L ++ ++ FLA H+LR PL I A+ ++ + I H+ I +SGQR++ Sbjct: 502 QLANKLKDEFLATTSHELRTPLHGMIGIAEALISGANGPISAAHKYQLDIIISSGQRLAT 561 Query: 209 LVADLLDYTRTHLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLKTSGELNGE--W 266 LV DLLDY + G+ L ++ + ++ A R++ E+S H TL+ +++ + W Sbjct: 562 LVDDLLDYHKMRYGA-LDIQRCAVDLSS-ATRLVLELS-HHLLGKKTLRIINQVSEQPVW 618 Query: 267 ---DKERIAQAISNLLGNAVQHGATGEAIKVEISASR--GEVHVAINNRGPLIPEEKLHT 321 D +R+ Q + NL+GNA+++ + G K+ ISA+ +V V + + G IP E+L Sbjct: 619 VSADPQRLEQVLYNLIGNAIKYTSEG---KIVISATYIDDKVRVQVVDTGQGIPAEQLEH 675 Query: 322 IFDPLVRLVANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRL 381 IF+PL+ + G + S GLGL I R++ G++ SS GTTF+ L Sbjct: 676 IFEPLI-------QAGHDASRYRQGAGLGLSISRQLIELMHGTLYVSSQPMVGTTFSFTL 728 Query: 382 P 382 P Sbjct: 729 P 729 >CAC0437 [T] COG0642 Signal transduction histidine kinase Cac Clostridium acetobutylicum Length = 637 Score = 94.7 bits (234), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/324 (24%), Positives = 140/324 (43%), Gaps = 38/324 (11%) Query: 96 FSVEQLASEYRALRSSVLRLWAKEWKEGYETNVDDITRFNEAIDQALAESLARYTKLLDQ 155 F VE+ YR ++ +W E+K E + ++ N+ +++ L S A+ Sbjct: 328 FLVEKYL--YRDKEIELVVVWDMEYKTKMEELKNRMSEKNDFLNKVLYYSNAKTQ----- 380 Query: 156 SRNLFLAILGHDLRNPLGATIHGAQIMLLAEDIDDRHRKIAARIY--------NSGQRMS 207 F+ + H+LR PL + Q+M L + D K R+Y +G R+ Sbjct: 381 ----FMGTISHELRTPLNIILSALQVMDLYANYGDLEEK--CRVYEKYSVVMKQNGYRLL 434 Query: 208 KLVADLLDYTRTHLGSGLPLEISSANVGDIAQRVIDEISTSHPDK---VITLKTSGELNG 264 K++ + +D T+ G+ L N+ I + V ++ DK +I E Sbjct: 435 KMINNFMDITQIEDGAR-KLNFVQGNIVTIVEDVTLAVAAFLKDKGKNIIFDTDVEEKIM 493 Query: 265 EWDKERIAQAISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFD 324 +DKE+I + + NLL NAV+ I+V I + +++ + G IPE+K IF+ Sbjct: 494 IFDKEKIERIVLNLLSNAVKFTGKDANIRVAIHDVGSNIQISVEDNGMGIPEDKKKMIFE 553 Query: 325 PLVRL---VANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRL 381 +L + EG G+GL IV+ + H G++ S G+ FT++L Sbjct: 554 RFFQLDKTFTRKNEGS----------GIGLSIVKLLVELHDGTIEVKSKVGIGSEFTVKL 603 Query: 382 PRDPSRRPADHQASPQVRHWEGDK 405 P S + + + +R DK Sbjct: 604 PVRKSNKYKNSYSDSLIRMSSKDK 627 >BH1581 [T] COG0642 Signal transduction histidine kinase Bha Bacillus halodurans Length = 594 Score = 91.3 bits (225), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 114/236 (48%), Gaps = 17/236 (7%) Query: 154 DQSRNLFLAILGHDLRNPLGATIHGAQIMLLAEDI---DDRHRKIAARIYNSGQRMSKLV 210 D+ R F+A + H+LR P+ + + G ++ +DI D +++A IY+ RM +LV Sbjct: 363 DKLRKDFIANVSHELRTPI-SMLQGYSEAII-DDIAGTDQEKKELAKIIYDESLRMGRLV 420 Query: 211 ADLLDYTRTHLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLK--TSGELNG--EW 266 +LLD R G + L V +R+ + ++ +TL G+ + Sbjct: 421 NELLDLARMEAGH-IDLSYEEIEVKTFCERITRKFQGLAKEQQLTLDFIYRGDEGKRIQV 479 Query: 267 DKERIAQAISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFDPL 326 D +R+ Q ++NLL NA++H G +++ V + + + G IPEE L +F+ Sbjct: 480 DPDRLEQVLTNLLSNAIRHTDPGGTVQLACHVMENGVKIDVTDTGTGIPEEDLPYVFERF 539 Query: 327 VRLVANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRLP 382 + R G+ G+ GLGL IV+ + AH G ++ S EGTTFT P Sbjct: 540 YKADKARTR------GRSGT-GLGLAIVKNIVDAHSGEISVHSKQQEGTTFTAFFP 588 >alr1171 [T] COG0642 Signal transduction histidine kinase Nos Nostoc sp. PCC 7120 Length = 448 Score = 90.9 bits (224), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 110/230 (47%), Gaps = 15/230 (6%) Query: 160 FLAILGHDLRNPLGATIHGAQIMLLAEDIDD-RHRKIAARIYNSGQRMSKLVADLLDYTR 218 F A H+LR PL AT + LL ID+ R I I QR++ LV DLL R Sbjct: 227 FTADAAHELRTPLAATGATVESALLMPKIDEPETRDILQTIQRQNQRLTTLVVDLLMLAR 286 Query: 219 T-HLGSGLPLEISSANVGDIAQRVIDEIST----SHPDKVITLKTSGELNGEWDKERIAQ 273 L E+ N DI +I+E + + + +++ LN + +++ + Sbjct: 287 LDRQAQKLQREVCCLN--DIVSDLIEEFAAMANAAGVKLIYSIRVKQNLNIMGNSDQLYR 344 Query: 274 AISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFDPLVRLVANR 333 +SNL+ NA+Q+ G + V + + + + + G IP+ +L IFD R+ ++R Sbjct: 345 LLSNLIVNAIQYTPKGGEVTVILERNDNYAVIKVQDTGIGIPQHELTRIFDRFYRVSSDR 404 Query: 334 GEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRLPR 383 GGS GLGL IV+ + AH GS+ S +G+TFTI L R Sbjct: 405 SRN------TGGS-GLGLAIVQAITEAHQGSIDVQSELGKGSTFTINLRR 447 >lin0316 [T] COG5002 Signal transduction histidine kinase Lin Listeria innocua Length = 610 Score = 90.9 bits (224), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 70/239 (29%), Positives = 111/239 (46%), Gaps = 23/239 (9%) Query: 153 LDQSRNLFLAILGHDLRNPLGATIHGAQIMLLAEDIDD---RHRKIAARIY----NSGQR 205 +DQ R F++ + H+LR PL ++H E + D ++IA R N +R Sbjct: 376 VDQERRDFVSNVSHELRTPL-TSMHS-----YLEALSDGAWEDKEIAPRFLEVTQNETER 429 Query: 206 MSKLVADLLDYTRTHLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLK--TSGELN 263 M +LV DLL +R G LE S N D +ID + ++ + + Sbjct: 430 MIRLVNDLLKLSRMD-GGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKRHIPKEPVI 488 Query: 264 GEWDKERIAQAISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIF 323 E D++++ Q + N++ NA ++ G I + E+ V+I + G +P+E L +F Sbjct: 489 IEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVPDEDLANVF 548 Query: 324 DPLVRLVANRGEGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAEGTTFTIRLP 382 D R+ R S + G GLGL I REV AHGG + A + ++GT LP Sbjct: 549 DRFFRVDKAR-------SREMGGTGLGLAIAREVIEAHGGRIWAERNKSKGTIIKFTLP 600 >all0978_3 [T] COG0642 Signal transduction histidine kinase Nos Nostoc sp. PCC 7120 Length = 246 Score = 89.7 bits (221), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 121/252 (48%), Gaps = 18/252 (7%) Query: 160 FLAILGHDLRNPLGATIHGAQIMLLAEDIDDRHRKIAARIYNSGQRMSKLVADLLDYTRT 219 FLA+L H+LR+PL + ++I+ + + + I + + ++L+ DLLD +R Sbjct: 5 FLAVLSHELRSPLNPILGWSRILRSKQLSPTKVEQALETIERNAKLQAQLIEDLLDVSRI 64 Query: 220 HLGSGLPLEISSANVGDIAQRVIDEISTSHPDKVITLKT-----SGELNGEWDKERIAQA 274 G + L ++S N+ ++ + + K I ++T S + G D+ R+ Q Sbjct: 65 LQGK-MTLNVASVNLAATIAAALETVQLAAEAKNIHIQTTLKPISATVVG--DQNRLQQV 121 Query: 275 ISNLLGNAVQHGATGEAIKVEISASRGEVHVAINNRGPLIPEEKLHTIFDPLVRLVANRG 334 + NLL NAV+ +G I+V++ + + + G I E L +F+ R Sbjct: 122 VWNLLSNAVKFTPSGGQIEVQLEQVNLYAQIQVKDSGKGIAREFLPYVFEYF------RQ 175 Query: 335 EGGGEGSGQGGSMGLGLYIVREVASAHGGSVTASSSTAE-GTTFTIRLPRDPSRR--PAD 391 E G + Q G +GLGL IVR HGG+V SS + G TFT+RLP + + PAD Sbjct: 176 EDGAT-TRQFGGLGLGLAIVRHFTELHGGTVQVSSLGQDLGATFTVRLPLNLVEQELPAD 234 Query: 392 HQASPQVRHWEG 403 + V G Sbjct: 235 DEQLKNVTDLTG 246