BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0372.p (4078 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 826 0.0 PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 810 0.0 PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 782 0.0 all2648_1 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 778 0.0 all2649 [Q] COG1020 Non-ribosomal peptide synthetase modules and... 767 0.0 all2643 [Q] COG1020 Non-ribosomal peptide synthetase modules and... 761 0.0 PA2402_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 739 0.0 PA2402_4 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 720 0.0 BS_ppsC_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 687 0.0 all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 684 0.0 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 826 bits (2133), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/1562 (38%), Positives = 821/1562 (52%), Gaps = 110/1562 (7%) Query: 685 VDGQSEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAAL 744 +D + PL+ +QQ +W WQL+PDS AYN+ G+ L G L V E AL L RH L Sbjct: 3 IDREQPVPLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETL 62 Query: 745 RTLFPLRDGTPVQQV-----LDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFR 799 RT FP DG PVQ+V L +D L D R+Q A + A + F Sbjct: 63 RTTFPSVDGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAH-------RPFD 115 Query: 800 LDSETPLRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPAL 859 L+S LR +V++ L + +HHI +GW++ I EL A YEA L Sbjct: 116 LESGPLLRVCMVKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPL 175 Query: 860 ELQPGDYAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQ-AGAHGGEGQH 918 +Q DY+VWQR+ + G E QRQLDYW+A+L LL LP DRPR +H G+ + Sbjct: 176 PVQYLDYSVWQREWLESG--ERQRQLDYWKAQLGNEHPLLELPGDRPRPPVQSHQGD-LY 232 Query: 919 RWRLSAALSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQA 978 R+ LS L+ +R+ A++G+T++ + A L R SGQ DL +GAP A+R R +++ Sbjct: 233 RFDLSPELAERVRRFNAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRPESEG 292 Query: 979 LVAYLINVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANP 1038 L+ +N QV+R R+D + L+ QV+Q V + Q+HQDLP D LV ALQP R A NP Sbjct: 293 LIGAFLNTQVLRCRLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNP 352 Query: 1039 LFQVKCTQQQ-AIATVRRMGGLDMRVELQAN--AESHFDLSLDFTDADEGIDILLAYAPA 1095 LFQV C Q+ R++ G M VE AN + FDL+L+ TD D+ + L Y+ Sbjct: 353 LFQVMCNVQRWEFQQTRQLAG--MTVEYIANDARATKFDLNLEVTDLDQRLGCCLTYSRD 410 Query: 1096 LFDAETVAGFAGLLQALAQQVVAAPALALADLQAFPPISAADQVLQ-----------PAE 1144 LFD +A AG Q L + ++ P +A+L P+ AA++ Q + Sbjct: 411 LFDEPRIARMAGHWQNLLEALLGDPQRRIAEL----PLFAAEERKQLLLAGTAGEAGLQD 466 Query: 1145 DVAACWRRQALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRG 1204 + + + A P A AL Q +S +L R + LA+ L + G GPE RV L R Sbjct: 467 TLHGLFAARVAASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERS 526 Query: 1205 IDFVCGMLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVL-HEGQSAPAWLAQAGVPL 1263 ++ V G+LA+L G AYVPLDP+ P ERL + ++DSG R +L H AGV Sbjct: 527 LEMVVGLLAILKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVAR 586 Query: 1264 LSLEAAGTAPASPWTPFPV----HPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLE 1319 LE G A + P P+ P AYLIYTSGSTG+PKGV V+ G +A + AAV+E Sbjct: 587 WCLEEDGPALDAE-DPAPLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIE 645 Query: 1320 KLALPAAARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVD 1379 + A + S L LC R ++ + + + V Sbjct: 646 CFGMRAEDCELHFYSINFDAASERLLAPLLCGARV--VLRAQGQWGAEEICELIRAEGVS 703 Query: 1380 VLKIVPSHLQALLHAARPE-QVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSE 1438 +L PS+ L + + LP + GGEA L+RI N YGP+E Sbjct: 704 ILGFTPSYGSQLAQWLESQGRQLPVRMCITGGEALTGEHLQRIRQAFAPASFFNAYGPTE 763 Query: 1439 TTVGVLAQEAAS-ASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARG 1497 T V LA A AA +P+GS + A++LD L P GA GELY+GGAGLARG Sbjct: 764 TVVMPLACLAPERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARG 823 Query: 1498 YHGRAALTAERFVAHPFAS-GQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGE 1556 YH R AL+AERFV PFA+ G RLYR+GD R +G +E++GRID QVKIRG R+E GE Sbjct: 824 YHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGE 883 Query: 1557 VRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADPA------GWRATLAAD 1610 + +LL V +A VLAL D QL G++ A + A + L Sbjct: 884 IEARLLEHPQVREALVLAL---DSPSGKQLAGYVASAVAEQDEDAQAALREALKTHLKQQ 940 Query: 1611 LPDYML-PTLTPVPALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQ 1669 LPDYM+ L + +LPLTANGKLDR+AL P +QA++ AP+ Sbjct: 941 LPDYMVPAHLLLLASLPLTANGKLDRRALPA-------------PDPALNRQAYE--APR 985 Query: 1670 GELEHKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQT 1729 LE +LA +W EVL + +VG DNFFELGGDSIL++++V+RAR+ G+ +P+ + + QT Sbjct: 986 SVLEQQLAGVWREVLNVERVGLGDNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQT 1045 Query: 1730 VAAIVAAGAVQGMLAATPAPAVVAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLNA-PG 1788 V ++ A A P D LTP+QHWFF+ A +HWNQ++LL Sbjct: 1046 VQSLAAVARHSQASQAEQGP----VQGDSALTPIQHWFFDLPLARREHWNQALLLQPRQA 1101 Query: 1789 LDAGVLRRALALLAQRHESLRLRFVQEGGQWRQRRGP-----ALLPLEIIDGDEPGAIAA 1843 +D G+LR++L L ++H++LRL F Q G+W + P L + + DE + A Sbjct: 1102 IDLGLLRKSLQRLVEQHDALRLAFRQVDGEWLAQHRPLREQELLWHVPVQSFDECAELFA 1161 Query: 1844 AGELVQRSLDLAQGPLMAAAWIRLDAQGKQGRLLLAGHHLVVDGVSWRVLLDDLAGLYHT 1903 QRSLDL QGPL+ A + +D + RLLLA HHLVVDGVSWRVLL+DL +Y Sbjct: 1162 KA---QRSLDLEQGPLLRA--VLVDGPAGEQRLLLAIHHLVVDGVSWRVLLEDLQQVYRQ 1216 Query: 1904 LQQGGTPAELPPATDLY-TWSQALRAHAQRPAVTDQLAYWRSV-----VDTP-EPPLADA 1956 +G PA LP T + W+ L+A+A ++ ++L +W++ V+ P + P D Sbjct: 1217 FAEGAEPA-LPAKTSAFRDWAGRLQAYAGSESLREELGWWQARLGGQPVEWPCDRPQGD- 1274 Query: 1957 TANLAGRAADAGFVLDADATARLLALGAHADPAVRVAPQDLLLAVLARVLCEWSGRDSLL 2016 N A LD T +LL A A R DLLL LARVLC WSG+ S L Sbjct: 1275 --NREALAESVSLRLDPQRTRQLL---QQAPAAYRTQVNDLLLTALARVLCRWSGQPSTL 1329 Query: 2017 FELEGHGREDIPGGLDVSRATGWFTALYPVRLAPGATSTSIPAALEAVRAQLRAVPANGL 2076 +LEGHGRE + +D++R+ GWFT+ YP+RL P + S +++A++ QLRAVP GL Sbjct: 1330 VQLEGHGREALFDDIDLTRSVGWFTSAYPLRLTP---AQSPGESIKAIKEQLRAVPHKGL 1386 Query: 2077 GYGLLRYLSGQGQELAQGAQPQ--ITFNYLGHFDHRIEPAGWTLADEYAGAQRAADSRRR 2134 GYG+LRYL+ A A P ITFNYLG FD A + D+ G + Sbjct: 1387 GYGVLRYLADPAVRQAMAALPTAPITFNYLGQFDQSFADALFQPLDQPTGPIHDEQAPLP 1446 Query: 2135 CLFEAIARVQQGRLQWQWTYCKDLHAAAEMRALQERLRTELMRWIEALEARAASDAAYAL 2194 +V G L +WTY ++ + A + L + EL IE D A L Sbjct: 1447 NELSVDGQVYGGELVLRWTYSRERYDARTVNELAQAYLAELQALIE----HCLEDGAGGL 1502 Query: 2195 SP 2196 +P Sbjct: 1503 TP 1504 Score = 543 bits (1400), Expect = e-153, Method: Compositional matrix adjust. Identities = 489/1424 (34%), Positives = 689/1424 (48%), Gaps = 122/1424 (8%) Query: 2194 LSPMQAGMFFHSSMNAGDGAYINQLRLDLAG-VDEVRLEAVWRDAVRRHPILRTGFRQQG 2252 LS Q M+F + AY L+G +D R EA + V+RH LRT F Sbjct: 11 LSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTFPSVD 70 Query: 2253 DAPEQWV-AQPVLHWRALDLSG-QPPQQQAQLEQIAAAELARGFDLAQPGLMRLVLAKLG 2310 P Q V LH D S +Q L+ +A +E R FDL L+R+ + K+ Sbjct: 71 GVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCMVKMA 130 Query: 2311 EGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAG---------EEIAAPTLAYRHYI-DWL 2360 E H+L+ T HH++ +GW+ E+ Y E + L Y + +WL Sbjct: 131 EREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQREWL 190 Query: 2361 QARDGAAARDFWRAQLQHLEEPTL-LAGALPRPREDASGHAEHLAAISPAQWQALCQAAK 2419 ++ + D+W+AQL + E P L L G PRP + + +SP + + + Sbjct: 191 ESGERQRQLDYWKAQLGN-EHPLLELPGDRPRPPVQSHQGDLYRFDLSPELAERVRRFNA 249 Query: 2420 AMRITPGTLLQGAWALVLQRCCGQSAVAFGVTVADR-PAELEGIESTLGLFINTLPLAVR 2478 A +T + A +L R GQ + G VA+R E EG+ +G F+NT L R Sbjct: 250 ARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRPESEGL---IGAFLNTQVLRCR 306 Query: 2479 LHAPQDCSDWLRALL--------HQNLAM----------REFAHAPLYEI----QRWSGR 2516 L + L + HQ+L R A+ PL+++ QRW + Sbjct: 307 LDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQ 366 Query: 2517 AGQALFDSILVLENYPMDEAIDRAADYGLHLSGLRLHEQTSYPLTVVATAQDGLSLRLGY 2576 + L + Y ++A RA + L+L L ++ LT Y Sbjct: 367 QTRQLAGMTV---EYIANDA--RATKFDLNLEVTDLDQRLGCCLT--------------Y 407 Query: 2577 DRSRFGAHQVAQLA-DWLAQALVTLTTAGARLGDCALGSATQRQQALDWSLNGQRFDGQE 2635 R F ++A++A W L R+ + L +A +R+Q L G+ Q+ Sbjct: 408 SRDLFDEPRIARMAGHWQNLLEALLGDPQRRIAELPLFAAEERKQLLLAGTAGEA-GLQD 466 Query: 2636 PVHRLFEQQASRRPDAIALQADGAHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERS 2695 +H LF + + P A AL G +Y +L+A +N LAR L++ GVGP+ V L ERS Sbjct: 467 TLHGLFAARVAASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERS 526 Query: 2696 AAMVTALLAVLKAGAAYLPLDPDYPAERLAWMLEDARPACLLSHRGLHHRLA-LPDTLLL 2754 MV LLA+LKAG AY+PLDP+YP ERL +M+ED+ LLSH L L LP + Sbjct: 527 LEMVVGLLAILKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVAR 586 Query: 2755 ELEDQLPGSQRGDDPQHNPQPPLHG-EHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQ 2813 ++ + +DP P L G +H AY+IYTSGSTG+PKG SH + + Sbjct: 587 WCLEEDGPALDAEDP--APLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVI 644 Query: 2814 QAYALQEGDAVLQKTPFGFDVSVWEFLWPLMTGARLVMAPPGAHRDPAELAALIREQGVS 2873 + + ++ D L FD + L PL+ GAR+V+ G E+ LIR +GVS Sbjct: 645 ECFGMRAEDCELHFYSINFDAASERLLAPLLCGARVVLRAQG-QWGAEEICELIRAEGVS 703 Query: 2874 TLHFVPS----MLQAFLASGQAAACTSLRQVICSGEALPAEARDQFFALLPQAALHNLYG 2929 L F PS + Q + G+ +R I GEAL E + A+ N YG Sbjct: 704 ILGFTPSYGSQLAQWLESQGRQ---LPVRMCITGGEALTGEHLQRIRQAFAPASFFNAYG 760 Query: 2930 PTEAAIDVTHWTCQHGDR-----GPVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGI 2984 PTE V C +R VPIG + A +LDADL ++P G GELY+GG Sbjct: 761 PTETV--VMPLACLAPERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGA 818 Query: 2985 GLARGYLGRPGLTAERFVASPFG-QGERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLR 3043 GLARGY RP L+AERFV PF +G RLYRTGDLVR ++GQ++Y+GR+DHQVKIRG R Sbjct: 819 GLARGYHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFR 878 Query: 3044 IELGEIEAQLLALDEVEEAVVVAHEHGAGPVLAGYVASRRWQRQDAA------TLKQALA 3097 IELGEIEA+LL +V EA+V+A + +G LAGYVAS ++ + A LK L Sbjct: 879 IELGEIEARLLEHPQVREALVLALDSPSGKQLAGYVASAVAEQDEDAQAALREALKTHLK 938 Query: 3098 ARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQA 3157 +LPDYMVPA L LL +LPL ANGK+DR+ALPAP AY AP+ +EQ+LA +W+ Sbjct: 939 QQLPDYMVPAHLLLLASLPLTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAGVWRE 998 Query: 3158 LLGLERVGRFDHFFELGGHSLLAASLVARLRYQGEAGVGVALPLRLVFAYPRLHEMAACI 3217 +L +ERVG D+FFELGG S+L+ +V+R R +G+ R +F + + +AA Sbjct: 999 VLNVERVGLGDNFFELGGDSILSIQVVSRARQ-----LGIHFSPRDLFQHQTVQSLAAVA 1053 Query: 3218 EGQAAIAAQQLPAAPAPLLQPGQRGAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALML 3277 A A+Q P + L+P QH W D A +N + L Sbjct: 1054 RHSQASQAEQGPVQ-----------GDSALTPIQH--WFFD--LPLARREHWNQALLLQP 1098 Query: 3278 EGVVDAVLLEQALRLLVARHDILRTGFGEDGDGNPVATLHPFDFSLEQHDLAALPPPQRD 3337 +D LL ++L+ LV +HD LR F + DG +A P EQ L +P D Sbjct: 1099 RQAIDLGLLRKSLQRLVEQHDALRLAFRQ-VDGEWLAQHRPLR---EQELLWHVPVQSFD 1154 Query: 3338 LQLDRLRRSHAAARFALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAA 3397 + ++ + L Q PLLRA LV +Q LLLAIHH+V DG S +++E++ Sbjct: 1155 ECAELFAKAQRS--LDLEQGPLLRAVLVDGPAGEQRLLLAIHHLVVDGVSWRVLLEDLQQ 1212 Query: 3398 AYSALQEGRPYAPPPLPLQYADYAAWQVAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTR 3457 Y EG A P + D+A A AGS L + + WW+ L G P P R Sbjct: 1213 VYRQFAEGAEPALPAKTSAFRDWAGRLQAYAGSESLREELGWWQARLGGQPVE--WPCDR 1270 Query: 3458 PCPARATHAGQRLRMHL-PAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVV 3516 P + + + L P R +Q +LL + A +L + SG +V Sbjct: 1271 PQGDNREALAESVSLRLDPQRTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPSTLV 1330 Query: 3517 GTDVAGRS----HPDLERLVGFFVNVLPLRLRPQALAPRASFAA 3556 + GR DL R VG+F + PLRL P A +P S A Sbjct: 1331 QLEGHGREALFDDIDLTRSVGWFTSAYPLRLTP-AQSPGESIKA 1373 Score = 202 bits (513), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 145/439 (33%), Positives = 206/439 (46%), Gaps = 16/439 (3%) Query: 3247 LSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGE 3306 LS +Q R+W + +L E D+ AYN+ L G +D E AL+ LV RH+ LRT F Sbjct: 11 LSYSQQRMWFLWQL--EPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTF-P 67 Query: 3307 DGDGNPVATLH-PFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAARFALRQPPLLRAALV 3365 DG PV +H ++ D +AL R L L S A F L PLLR +V Sbjct: 68 SVDGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCMV 127 Query: 3366 RLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQYADYAAWQV 3425 ++A ++ L++ +HHIV +GW++ + E+ A Y A + R PLP+QY DY+ WQ Sbjct: 128 KMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQR 187 Query: 3426 AGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQRLRMHLPAHLRSGVQAL 3485 S + + +W+ L LP RP P +H G R L L V+ Sbjct: 188 EWLESGERQRQLDYWKAQLGNEHPLLELPGDRPRPPVQSHQGDLYRFDLSPELAERVRRF 247 Query: 3486 ARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRSHPDLERLVGFFVNVLPLRLRP 3545 G+T + + A+ A LL++ SG D +G VA R P+ E L+G F+N LR R Sbjct: 248 NAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRPESEGLIGAFLNTQVLRCR- 306 Query: 3546 QALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQVLFVLQNTP 3605 L + S L ++ HQ+ FD +VEA PR +NPL QV+ +Q Sbjct: 307 --LDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWE 364 Query: 3606 -RAALALPGVRAELLEPLENWSKFDLALFVEDHAEAGDAEDGPGWRADWVYADALFDAAT 3664 + L G+ E + +KFDL L V D D G Y+ LFD Sbjct: 365 FQQTRQLAGMTVEYIANDARATKFDLNLEVTDL----DQRLG----CCLTYSRDLFDEPR 416 Query: 3665 VAALGRDWQRLLEQVLASP 3683 +A + WQ LLE +L P Sbjct: 417 IARMAGHWQNLLEALLGDP 435 Score = 143 bits (361), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 239/881 (27%), Positives = 354/881 (40%), Gaps = 127/881 (14%) Query: 54 FSFAQLDLRARAYAAAFQQRC--PQGARVLLVLENDEHYVQAFLGCLYAGMVAVPVFPPE 111 S+A+LD R+ A + P+ RV L LE V L L AG VP+ P Sbjct: 492 LSYAELDARSNRLARVLRSHGVGPE-VRVGLALERSLEMVVGLLAILKAGGAYVPLDPEY 550 Query: 112 SVRPQHLKRLAGIAADAQAACVVLPEPLRQTCAQAALFGAAELLAAEQV-----ADADAV 166 L+RL + D+ +R + AALF A L A D A+ Sbjct: 551 P-----LERLQYMIEDSG---------VRLLLSHAALFEALGELPAGVARWCLEEDGPAL 596 Query: 167 HWREHTP-----QPQDIAFLQYTSGSTSAPKGVMVSHGNLMANEAAISACMRVREDDIFV 221 + P PQ A+L YTSGST PKGV VSHG + + AA+ C +R +D + Sbjct: 597 DAEDPAPLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCEL 656 Query: 222 TWLPLYHDMGLIGGLLQGLVRGLKTVLCSPRYFLERPLRW-----LELVARHRGTVSG-G 275 + + D R L +LC R L +W EL+ ++ G Sbjct: 657 HFYSINFDA--------ASERLLAPLLCGARVVLRAQGQWGAEEICELIRAEGVSILGFT 708 Query: 276 PDFAYRLCVERIKPAQLQGVDLSSWRVAFCGAEPLRADTFPAFIERFCAAGFSADAAYPC 335 P + +L + + QG L R+ G E L + + F A F + Sbjct: 709 PSYGSQLA----QWLESQGRQLPV-RMCITGGEALTGEHLQRIRQAFAPASF-----FNA 758 Query: 336 YGLAEATLIVSGGPPHGAHATAFHTAELAAGRAVEGGPDDTRLVACGDIAPHHEVRIIE- 394 YG E ++ A LA R EG V G + I++ Sbjct: 759 YGPTETVVMP--------------LACLAPERLEEGAAS----VPIGSVVGARVAYILDA 800 Query: 395 DGRVQQDGAVGEIEVCGPSVTQGYWQRPQQSAAAFVER----DGRRWLRTGDLGFLRD-G 449 D + GA GE+ V G + +GY +RP SA FV +G R RTGDL L D G Sbjct: 801 DLALVPQGATGELYVGGAGLARGYHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNG 860 Query: 450 QLYIAGRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAEIS 509 Q+ GR + +RG + +IE + + + VR+ V A +G+ VA+ ++ Sbjct: 861 QVEYVGRIDHQVKIRGFRIELGEIEARLLEHPQ-VREALVLALDSPSGKQLAGYVASAVA 919 Query: 510 RGMQKLAAPGVIASAIAEAVAQSSLEAPQVVILLNPGGLPKTSSGKLQRSACRSGWRNGE 569 Q A + A+ + Q + LL LP T++GKL R A + Sbjct: 920 E--QDEDAQAALREALKTHLKQQLPDYMVPAHLLLLASLPLTANGKLDRRALPA------ 971 Query: 570 LDAWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQADFFRSG 629 D E P+ +E LA +W+ L G +FF G Sbjct: 972 ----------------PDPALNRQAYEAPRSVLEQQLAGVWREVLNVERVGLGDNFFELG 1015 Query: 630 GSSLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPLPACVDGQS 689 G S+ ++QVV+ + + F+P LF T+ + AA + A+ P+ Q Sbjct: 1016 GDSILSIQVVSR-ARQLGIHFSPRDLFQHQTVQSLAAVARHSQASQAEQGPV------QG 1068 Query: 690 EFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFP 749 + LT Q W +N A +L + + L +L L +H ALR F Sbjct: 1069 DSALTPIQH--WFFDLPLARREHWNQALLLQPRQAIDLGLLRKSLQRLVEQHDALRLAFR 1126 Query: 750 LRDGTPVQQVLDIDEARPMLLRSDLRRQPA---DKRAQAAASALQRFHAQAFRLDSETPL 806 DG + Q RP+ + L P D+ A+ A A ++ L+ L Sbjct: 1127 QVDGEWLAQ------HRPLREQELLWHVPVQSFDECAELFAKA-----QRSLDLEQGPLL 1175 Query: 807 RAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDY 866 RA+LV A RL L IHH+ DG S ++L++L Y GA P+ PA D+ Sbjct: 1176 RAVLVDGPAGEQRLLLAIHHLVVDGVSWRVLLEDLQQVYRQFAEGAEPALPAKTSAFRDW 1235 Query: 867 AVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPR 907 A R ++ GS + +L +W+ARL G P + P DRP+ Sbjct: 1236 A--GRLQAYAGSESLREELGWWQARLGGQP--VEWPCDRPQ 1272 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 810 bits (2091), Expect = 0.0, Method: Compositional matrix adjust. Identities = 578/1537 (37%), Positives = 799/1537 (51%), Gaps = 97/1537 (6%) Query: 680 PLPACVDGQSEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAA 739 P+PA V L+ AQQ +W W L+P S AYNL + L G L +ALE A L Sbjct: 39 PIPAGVSSAERDRLSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQ 98 Query: 740 RHAALRTLFPL-RDGTPVQQVLDIDEARPM-LLRSDLRRQPADKRAQAAASALQRFHAQA 797 RH LRT+FP D + Q L RP+ + D P D++ QR Q Sbjct: 99 RHETLRTVFPRGADDSLAQAPLQ----RPLEVAFEDCSGLPEDEQEARLREEAQRESLQP 154 Query: 798 FRLDSETPLRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWP 857 F L LR L++L L L +HHI +DGWS+ ++++E + Y A GA P P Sbjct: 155 FDLCEGPLLRVRLIRLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLP 214 Query: 858 ALELQPGDYAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQ 917 AL +Q DYA+WQR + G E +RQL+YWR +L +L LPTD PR A + Sbjct: 215 ALPIQYADYALWQRSWLEAG--EQERQLEYWRGKLGERHPVLELPTDHPRPAVPSYRGSR 272 Query: 918 HRWRLSAALSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQ 977 + + + AL+ ALR A QG+TL+ +L F + LQR SGQ+DL VG P A+R R + + Sbjct: 273 YEFSIEPALAEALRGTARRQGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRAEVE 332 Query: 978 ALVAYLINVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGAN 1037 L+ +N QV+R+ D R+ L+ ++ V AQAHQDLP + LV A + ER + Sbjct: 333 GLIGLFVNTQVLRSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHS 392 Query: 1038 PLFQVKCTQQQAIATVR---RMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAP 1094 PLFQV Q +A + + GL + + FDLSLD + + L YA Sbjct: 393 PLFQVMYNHQPLVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYEKGGRLYAALTYAT 452 Query: 1095 ALFDAETVAGFAGLLQALAQQVVAAPALALADLQAFPPISAAD--QVLQPAEDVAA---- 1148 LF+A TV A Q L + ++ P A + + P + A + Q+L+ AA Sbjct: 453 DLFEARTVERMARHWQNLLRGMLENPQ---ASVDSLPMLDAEERGQLLEGWNATAAEYPL 509 Query: 1149 ------CWRRQALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAG 1202 + Q P A AL G + + +L +R + LA L G G + V + Sbjct: 510 QRGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAME 569 Query: 1203 RGIDFVCGMLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQ-SAPAWLAQAGV 1261 R I+ V ++A+L G AYVP+DP+ P ER A+ L+DSG + +L + P LAQ GV Sbjct: 570 RSIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLP--LAQ-GV 626 Query: 1262 PLLSLEAAGTAPASPWTPFP---VHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVL 1318 + L+ A + P ++ AY+IYTSGSTG+PKG L+N + + Sbjct: 627 QRIDLDQADAWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQ 686 Query: 1319 EKLALPAAARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAV 1378 + L ++ + + D+ + L SG +L + DP ++ V Sbjct: 687 QAYGL-GVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGV 745 Query: 1379 DVLKIVPSHLQALLHAARPEQVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSE 1438 D L VPS LQA L +V GEA +++ A P + N YGP+E Sbjct: 746 DTLHFVPSMLQAFLQDEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTE 805 Query: 1439 TTVGVLAQEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGY 1498 + V + A +P+G +A + ++LD L PVG +GELYL G GLARGY Sbjct: 806 AAIDVTHWTCVEEGKDA--VPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGY 863 Query: 1499 HGRAALTAERFVAHPFASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVR 1558 H R LTAERFVA PF +G+R+YR+GD ARY DG IE+ GRID QVK+RG R+E GE+ Sbjct: 864 HQRPGLTAERFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIE 923 Query: 1559 QQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAA----DLPDY 1614 +LL V +AAVLA+ QL G++V ++ WR LAA LP+Y Sbjct: 924 ARLLEHPWVREAAVLAVDGK------QLVGYVVLE----SEGGDWREALAAHLATSLPEY 973 Query: 1615 MLPT-LTPVPALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGELE 1673 M+P + +PL+ NGKLDR+AL P+V AQ + AP+ +E Sbjct: 974 MVPAQWLALERMPLSPNGKLDRKALPA-------------PEVSVAQAGY--SAPRNAVE 1018 Query: 1674 HKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQTVAAI 1733 LA IW ++L + QVG DDNFF LGGDSI+++++V+RAR+ GL+++P+ + + Q + ++ Sbjct: 1019 RTLAEIWQDLLGVEQVGLDDNFFSLGGDSIVSIQVVSRARQAGLQLSPRDLFQHQNIRSL 1078 Query: 1734 VAAGAVQGMLAAT-PAPAVVAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLNA-PGLDA 1791 A A PA VA L PVQ WFFEQ QHWNQS+LL A LD Sbjct: 1079 ALAAKAGAATAEQGPASGEVA------LAPVQRWFFEQSIPNRQHWNQSLLLQARQPLDG 1132 Query: 1792 GVLRRALALLAQRHESLRLRFVQEGGQWRQRRGP-ALLPLEIIDGDEPGAIAAAGELVQR 1850 L RAL L +H++LRLRF +E G W Q A PL + A E QR Sbjct: 1133 DRLGRALERLQAQHDALRLRFREERGAWHQAYAEQAGEPLWRRQAGSEEVLLALCEEAQR 1192 Query: 1851 SLDLAQGPLMAAAWIRLDAQGKQGRLLLAGHHLVVDGVSWRVLLDDLAGLYHTLQQGGTP 1910 SLDL QGPL+ A + + A G Q RLLL HHL VDGVSWR+LL+DL LY L Sbjct: 1193 SLDLEQGPLLRALLVDM-ADGSQ-RLLLVIHHLAVDGVSWRILLEDLQRLYADLD----- 1245 Query: 1911 AELPPATDLY-TWSQALRAHAQRPAVTDQLAYWRSVV-DTPEP-PLADATANLAGR-AAD 1966 A+L P + Y WS+ L H Q A D+L YW++ + D P P + L R Sbjct: 1246 ADLGPRSSSYQAWSRHL--HEQAGARLDELDYWQAQLHDAPHALPCENPHGALENRHERK 1303 Query: 1967 AGFVLDADATARLLALGAHADPAVRVAPQDLLLAVLARVLCEWSGRDSLLFELEGHGRED 2026 LDA+ T +LL A A R DLLL LAR C WSG S+L +LEGHGRED Sbjct: 1304 LVLTLDAERTRQLL---QEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHGRED 1360 Query: 2027 IPGGLDVSRATGWFTALYPVRLAPGATSTSIPAALEAVRAQLRAVPANGLGYGLLRYLSG 2086 + +D+SR GWFT+L+P+RL P A + +L+A++ QLR VP G+GYGLLRYL+G Sbjct: 1361 LGEAIDLSRTVGWFTSLFPLRLTPAA---DLGESLKAIKEQLRGVPDKGVGYGLLRYLAG 1417 Query: 2087 Q--GQELAQGAQPQITFNYLGHFDHRIEPAGWTL-ADEYAGAQRAADSRRRCLFEAIARV 2143 + LA QP+ITFNYLG FD + + A + A E AGA + + +V Sbjct: 1418 EEAATRLAALPQPRITFNYLGRFDRQFDGAALLVPATESAGAAQDPCAPLANWLSIEGQV 1477 Query: 2144 QQGRLQWQWTYCKDLHAAAEMRALQERLRTELMRWIE 2180 G L W++ +++ A A ++ L + EL IE Sbjct: 1478 YGGELSLHWSFSREMFAEATVQRLVDDYARELHALIE 1514 Score = 756 bits (1951), Expect = 0.0, Method: Compositional matrix adjust. Identities = 603/1585 (38%), Positives = 791/1585 (49%), Gaps = 163/1585 (10%) Query: 2194 LSPMQAGMFFHSSMNAGDGAYINQLRLDLAG-VDEVRLEAVWRDAVRRHPILRTGF-RQQ 2251 LS Q M+F + GAY + L G +D LE + V+RH LRT F R Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 2252 GDAPEQWVAQPVLHWRALDLSGQPP-QQQAQLEQIAAAELARGFDLAQPGLMRLVLAKLG 2310 D+ Q Q L D SG P +Q+A+L + A E + FDL + L+R+ L +LG Sbjct: 112 DDSLAQAPLQRPLEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRLIRLG 171 Query: 2311 EGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYA----GEEIAAPTL--AYRHYI----DWL 2360 E RH L+ T HH++ DGWS L E R Y+ G E P L Y Y WL Sbjct: 172 EERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQRSWL 231 Query: 2361 QARDGAAARDFWRAQLQHLEEPTLLAGALPRPREDASGHAEHLAAISPAQWQALCQAAKA 2420 +A + ++WR +L L PRP + + + +I PA +AL A+ Sbjct: 232 EAGEQERQLEYWRGKLGERHPVLELPTDHPRPAVPSYRGSRYEFSIEPALAEALRGTARR 291 Query: 2421 MRITPGTLLQGAWALVLQRCCGQSAVAFGVTVADRP-AELEGIESTLGLFINTLPLAVRL 2479 +T LL G + ++LQR GQ+ + GV +A+R AE+EG+ +GLF+NT L Sbjct: 292 QGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRAEVEGL---IGLFVNTQVLRSVF 348 Query: 2480 HAPQDCSDWLRALL--------HQNLAM----------REFAHAPLYEIQRWSGRAGQAL 2521 + L L HQ+L R +H+PL+++ Q L Sbjct: 349 DGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHSPLFQVMY----NHQPL 404 Query: 2522 FDSILVLENYPMDEAIDRAADYGLHLSGLRLHEQTSYPLTVVATAQDG--LSLRLGYDRS 2579 I EA+D A GL L +T+ + T + G L L Y Sbjct: 405 VADI---------EALDSVA--GLSFGQLDWKSRTTQFDLSLDTYEKGGRLYAALTYATD 453 Query: 2580 RFGAHQVAQLA-DWLAQALVTLTTAGARLGDCALGSATQRQQALD-WSLNGQRFDGQEPV 2637 F A V ++A W L A + + A +R Q L+ W+ + Q V Sbjct: 454 LFEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGV 513 Query: 2638 HRLFEQQASRRPDAIALQADGAHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAA 2697 HRLFE+Q R P A AL Y +LN AN LA L GVG D +V + ERS Sbjct: 514 HRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIE 573 Query: 2698 MVTALLAVLKAGAAYLPLDPDYPAERLAWMLEDARPACLLSHRGLHHRLALPDTLLLELE 2757 MV AL+A+LKAG AY+P+DP+YP ER A+MLED+ LLS H +L L + Sbjct: 574 MVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQS--HLKLPLAQGVQRIDL 631 Query: 2758 DQLPGSQRGDDPQHNPQPPLHGEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYA 2817 DQ + + ++NP L+GE+LAYVIYTSGSTG+PKGAGN H AL NRL WMQQAY Sbjct: 632 DQ-ADAWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYG 690 Query: 2818 LQEGDAVLQKTPFGFDVSVWEFLWPLMTGARLVMAPPGAHRDPAELAALIREQGVSTLHF 2877 L GD VLQKTPF FDVSVWEF WPLM+GARLV+A PG HRDPA+L LI +GV TLHF Sbjct: 691 LGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHF 750 Query: 2878 VPSMLQAFLASGQAAACTSLRQVICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDV 2937 VPSMLQAFL A+CTSL++++CSGEALPA+A+ Q FA LPQA L+NLYGPTEAAIDV Sbjct: 751 VPSMLQAFLQDEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTEAAIDV 810 Query: 2938 THWTCQHGDRGPVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLT 2997 THWTC + VPIG+PI+ L +LD +L +P GV GELYL G GLARGY RPGLT Sbjct: 811 THWTCVEEGKDAVPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGYHQRPGLT 870 Query: 2998 AERFVASPFGQGERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALD 3057 AERFVASPF GER+YRTGDL R+R DG I+Y GR+DHQVK+RGLRIELGEIEA+LL Sbjct: 871 AERFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHP 930 Query: 3058 EVEEAVVVAHEHGAGPVLAGYVASRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPL 3117 V EA V+A + G L GYV L LA LP+YMVPA L +PL Sbjct: 931 WVREAAVLAVD---GKQLVGYVVLESEGGDWREALAAHLATSLPEYMVPAQWLALERMPL 987 Query: 3118 NANGKIDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHS 3177 + NGK+DRKALPAP + Y+AP+ VE+ LA+IWQ LLG+E+VG D+FF LGG S Sbjct: 988 SPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQDLLGVEQVGLDDNFFSLGGDS 1047 Query: 3178 LLAASLVARLRYQGEAGVGVALPLRLVFAYPRLHEMAACIEGQAAIAAQQLPAAPAPLLQ 3237 +++ +V+R R G+ L R +F + + +A + A A+Q PA+ L Sbjct: 1048 IVSIQVVSRARQ-----AGLQLSPRDLFQHQNIRSLALAAK-AGAATAEQGPASGEVALA 1101 Query: 3238 PGQRGAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARH 3297 P QR W ++ + +N S L +D L +AL L A+H Sbjct: 1102 PVQR-------------WFFEQ--SIPNRQHWNQSLLLQARQPLDGDRLGRALERLQAQH 1146 Query: 3298 DILRTGFGEDGD----------GNPVATLHPFDFSLEQHDLAALPPPQRDLQLDRLRRSH 3347 D LR F E+ G P+ E+ LA QR L L+ Sbjct: 1147 DALRLRFREERGAWHQAYAEQAGEPLWRRQA---GSEEVLLALCEEAQRSLDLE------ 1197 Query: 3348 AAARFALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRP 3407 Q PLLRA LV +A Q LLL IHH+ DG S +++E++ Y+ L Sbjct: 1198 --------QGPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLYADLD---- 1245 Query: 3408 YAPPPLPLQYADYAAWQV---AGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARAT 3464 L + + Y AW AG+R+ D + +W+ L P LP P A Sbjct: 1246 ---ADLGPRSSSYQAWSRHLHEQAGARL--DELDYWQAQLHDAPHA--LPCENPHGALEN 1298 Query: 3465 HAGQRLRMHLPAH-LRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGR 3523 ++L + L A R +Q +LL + A + SG +V + GR Sbjct: 1299 RHERKLVLTLDAERTRQLLQEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHGR 1358 Query: 3524 SH----PDLERLVGFFVNVLPLRLRPQALAPRA--SFAAWLRHCADVAVNAFDHQEPGFD 3577 DL R VG+F ++ PLRL P A + + LR D V G+ Sbjct: 1359 EDLGEAIDLSRTVGWFTSLFPLRLTPAADLGESLKAIKEQLRGVPDKGV--------GYG 1410 Query: 3578 RIVEAAGVPRERRWNPLVQVLFVLQNTPR-------AALALP-----GVRAELLEPLENW 3625 + AG R L Q R AAL +P G + PL NW Sbjct: 1411 LLRYLAGEEAATRLAALPQPRITFNYLGRFDRQFDGAALLVPATESAGAAQDPCAPLANW 1470 Query: 3626 SKFDLALFVEDHAEAGDAEDGPGWRADWVYADALFDAATVAALGRDWQRLLEQVLASPWT 3685 L +E G+ W ++ +F ATV L D+ R L ++ Sbjct: 1471 ------LSIEGQVYGGELS------LHWSFSREMFAEATVQRLVDDYARELHALIEHCLD 1518 Query: 3686 PLDAALPSSPSDTKAEVPSQVLLDE 3710 P + +PSD SQ LDE Sbjct: 1519 PRHRGV--TPSDFPLAGLSQTQLDE 1541 Score = 127 bits (318), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 249/955 (26%), Positives = 373/955 (39%), Gaps = 158/955 (16%) Query: 48 ASGERRFSFAQLDLRARAYAAAFQQRCPQGARVLLV-LENDEHYVQAFLGCLYAGMVAVP 106 A GE R +A+L+ RA A A +R R++ V +E V A + L AG VP Sbjct: 531 AFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYVP 590 Query: 107 VFP--PESVRPQHLKRLAGIAADAQAACVVLPEPLRQTCAQAALFGAAELLAAEQVADAD 164 V P PE +R A + D+ ++ L+ AQ + + +Q ADA Sbjct: 591 VDPEYPE-------ERQAYMLEDSGVQLLLSQSHLKLPLAQGV-----QRIDLDQ-ADAW 637 Query: 165 AVHWREHTP----QPQDIAFLQYTSGSTSAPKGVMVSHGNLMANEAAISACMRVREDDIF 220 + E+ P +++A++ YTSGST PKG H L + + D Sbjct: 638 LENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTV 697 Query: 221 VTWLPLYHDMGLIGGLLQGLVRGLKTVLCSPRYFLERPLRWLELVARHRGTVSGGPDFAY 280 + P D+ + L+ G + V+ +P + P + +EL+ R G D + Sbjct: 698 LQKTPFSFDVS-VWEFFWPLMSGARLVVAAPGDHRD-PAKLVELINRE------GVDTLH 749 Query: 281 RLCVERIKPAQLQGVDL---SSWRVAFCGAEPLRADTFPAFIERFCAAGFSADAAYPCYG 337 V + A LQ D+ +S + C E L AD + AG Y YG Sbjct: 750 --FVPSMLQAFLQDEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGL-----YNLYG 802 Query: 338 LAEATLIVSGGPPHGAHATAFHTAELAA--GRAVEGGPDDTRLVACGDIAPHHEVRIIED 395 EA + V+ H T + A GR + +AC I D Sbjct: 803 PTEAAIDVT-------HWTCVEEGKDAVPIGRPIAN-------LAC----------YILD 838 Query: 396 GRVQQD--GAVGEIEVCGPSVTQGYWQRPQQSAAAFVERD---GRRWLRTGDLGFLR-DG 449 G ++ G +GE+ + G + +GY QRP +A FV G R RTGDL R DG Sbjct: 839 GNLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFVAGERMYRTGDLARYRADG 898 Query: 450 QLYIAGRRKDLIIVRGQNVYPQDIERAV-------EDQVEAVRKGRVAAFAVNTGEGEGI 502 + AGR + +RG + +IE + E V AV ++ + V EG Sbjct: 899 VIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVDGKQLVGYVVLESEG--- 955 Query: 503 GVAAEISRGMQKLAAPGVIASAIAEAVAQSSLEAPQVVILLNPGGLPKTSSGKLQRSACR 562 G + A +A+++ E + + A + +P + +GKL R A Sbjct: 956 --------GDWREALAAHLATSLPEYMVPAQWLALE--------RMPLSPNGKLDRKA-- 997 Query: 563 SGWRNGELDAWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQ 622 L A + S AQ G P+ +E LA IWQ L G Sbjct: 998 -------LPAPEV----------SVAQAG---YSAPRNAVERTLAEIWQDLLGVEQVGLD 1037 Query: 623 ADFFRSGGSSLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPLP 682 +FF GG S+ ++QVV+ + ++ +P LF + + A A T Q P Sbjct: 1038 DNFFSLGGDSIVSIQVVSR-ARQAGLQLSPRDLFQHQNIRSLALAAKAGAATAEQG---P 1093 Query: 683 ACVDGQSEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHA 742 A E L Q+ W Q P+ +N + +L L + L AL L A+H Sbjct: 1094 AS----GEVALAPVQR--WFFEQSIPNRQHWNQSLLLQARQPLDGDRLGRALERLQAQHD 1147 Query: 743 ALRTLFPLRDGTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDS 802 ALR F G Q P+ RRQ ++ AL ++ L+ Sbjct: 1148 ALRLRFREERGA-WHQAYAEQAGEPL-----WRRQAG---SEEVLLALCEEAQRSLDLEQ 1198 Query: 803 ETPLRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQ 862 LRA+LV + RL L IHH+A DG S I+L++L Y A P + Sbjct: 1199 GPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLYADLDADLGP-------R 1251 Query: 863 PGDYAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGG-EGQHRWR 921 Y W R + +LDYW+A+L AP LP + P HG E +H + Sbjct: 1252 SSSYQAWSRHLHEQAGARLD-ELDYWQAQLHDAPH--ALPCENP-----HGALENRHERK 1303 Query: 922 LSAALSTA-----LRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADR 971 L L L++ A+ + +L A R SG + + V G R Sbjct: 1304 LVLTLDAERTRQLLQEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHGR 1358 >PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1495 Score = 782 bits (2019), Expect = 0.0, Method: Compositional matrix adjust. Identities = 572/1529 (37%), Positives = 791/1529 (51%), Gaps = 108/1529 (7%) Query: 689 SEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLF 748 +E PL+ AQQ +W W+L+P+SAAY+L VL + G L AL+ A L RH LRT F Sbjct: 2 AELPLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRF 61 Query: 749 PLRDGTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHA---QAFRLDSETP 805 DG Q +L M LR L D + A+ QR Q F L Sbjct: 62 EEVDGQARQTIL-----ANMPLRIVLE----DCAGASEATLRQRVAEEIRQPFDLARGPL 112 Query: 806 LRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGD 865 LR L+ L L + HHI +DGWS+ +++DEL AY A G P+ L LQ D Sbjct: 113 LRVRLLALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYAD 172 Query: 866 YAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSAA 925 YA W R G E RQLDYWR RL +L LP DR R A A G + L + Sbjct: 173 YAAWHRAWLDSG--EGARQLDYWRERLGAEQPVLELPADRVRPAQASGRGQRLDMALPVS 230 Query: 926 LSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQALVAYLIN 985 LS L A +GVT + +LA F + L+R SGQSD+ VG P A+R R + + L+ + +N Sbjct: 231 LSEELLACARREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRAEVERLIGFFVN 290 Query: 986 VQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCT 1045 QV+R ++D F L+ +V++A AQAHQDLP + LV ALQPER +PLFQV Sbjct: 291 TQVLRCQVDAGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVMYN 350 Query: 1046 QQQAIATVRRMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGF 1105 Q ++ GL + A + FDL+LD + +G+ L YA LF+A TV Sbjct: 351 HQSGERQDAQVDGLHIESFAWDGAAAQFDLALDTWETPDGLGAALTYATDLFEARTVERM 410 Query: 1106 AGLLQALAQQVVAAPALALADLQAFPPISAAD--QVLQPAEDVAA----------CWRRQ 1153 A Q L + ++ P A + + P + A + Q+L+ AA + Q Sbjct: 411 ARHWQNLLRGMLENPQ---ASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHRLFEEQ 467 Query: 1154 ALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLA 1213 P A AL G + + +L +R + LA L G G + V + R I+ V ++A Sbjct: 468 VERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMA 527 Query: 1214 VLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQ-SAPAWLAQAGVPLLSLEAA--- 1269 +L G AYVP+DP+ P ER A+ L+DSG + +L + P LAQ GV + L+ A Sbjct: 528 ILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLP--LAQ-GVQRIDLDQADAW 584 Query: 1270 --GTAPASPWTPFPVHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAA 1327 A +P ++ AY+IYTSGSTG+PKG L+N + + + L Sbjct: 585 LENHAENNP--GIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGL-GVG 641 Query: 1328 RSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSH 1387 ++ + + D+ + L SG +L + DP A ++ VD L VPS Sbjct: 642 DTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLHFVPSM 701 Query: 1388 LQALLHAARPEQVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSETTVGVLAQE 1447 LQA L +V GEA +++ A P + N YGP+E + V Sbjct: 702 LQAFLQDEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTEAAIDVTHWS 761 Query: 1448 AASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALTAE 1507 + A +P+G +A + ++LD L PVG +GELYL G GLARGYH R LTAE Sbjct: 762 CVEEGKDA--VPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGYHQRPGLTAE 819 Query: 1508 RFVAHPFASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRLAGV 1567 RFVA PF +G+R+YR+GD ARY DG IE+ GRID QVK+RG R+E GE+ +LL V Sbjct: 820 RFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWV 879 Query: 1568 VDAAVLALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAA----DLPDYMLPT-LTPV 1622 +AAVLA+ + QL G++V ++ WR LAA LP+YM+P + Sbjct: 880 REAAVLAVDSR------QLVGYVVLE----SEGGDWREALAAHLATSLPEYMVPAQWLAL 929 Query: 1623 PALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGELEHKLAAIWAE 1682 +PL+ NGKLDR+AL P+ Q A Q H APQ E+E ++AA+WA+ Sbjct: 930 ERMPLSPNGKLDRKAL----------PRPQAA----AGQTHV--APQNEMERRIAAVWAD 973 Query: 1683 VLKLPQVGRDDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQTVAAIVAAGAVQGM 1742 VLKL +VG DNFF LGGDSI+++++V+R R G++ PK + ++QTV + V Sbjct: 974 VLKLEEVGATDNFFALGGDSIVSIQVVSRCRAAGIQFTPKDLFQQQTVQGLARVARVGAA 1033 Query: 1743 LAATPAPAVVAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLNA-PGLDAGVLRRALALL 1801 + P + L P Q FFEQ QHWNQS+LL L+A L AL L Sbjct: 1034 VQMEQGP----VSGETVLLPFQRLFFEQPIPNRQHWNQSLLLKPREALNAKALEAALQAL 1089 Query: 1802 AQRHESLRLRFVQEGGQWRQRRGPALLPLEII---DGDEPGAIAAAGELVQRSLDLAQGP 1858 + H++LRLRF + G W A L ++ + + A+ + E QRSLDLA GP Sbjct: 1090 VEHHDALRLRFHETDGTWHAEHAEATLGGALLWRAEAVDRQALESLCEESQRSLDLADGP 1149 Query: 1859 LMAAAWIRLDAQGKQGRLLLAGHHLVVDGVSWRVLLDDLAGLYHTLQQGGTPAELPPATD 1918 L+ + + + A G Q RLLL HHLVVDGVSWR+LL+DL Y +G P LP T Sbjct: 1150 LLRSLLVDM-ADGGQ-RLLLVIHHLVVDGVSWRILLEDLQRAYQQSLRGEAP-RLPGKTS 1206 Query: 1919 LYT-WSQALRAHAQRPAVTDQLAYWRSVVD--TPEPPLADATANLAGR-AADAGFVLDAD 1974 + W+ + HA+ ++ QL +WR +++ E P L R A D Sbjct: 1207 PFKAWAGRVSEHARGESMKAQLQFWRELLEGAPAELPCEHPQGALEQRFATSVQSRFDRS 1266 Query: 1975 ATARLLALGAHADPAVRVAPQDLLLAVLARVLCEWSGRDSLLFELEGHGREDIPGGLDVS 2034 T RLL A A R DLLL LARV+C WSG S L +LEGHGRE++ +D+S Sbjct: 1267 LTERLL---KQAPAAYRTQVNDLLLTALARVVCRWSGASSSLVQLEGHGREELFADIDLS 1323 Query: 2035 RATGWFTALYPVRLAPGATSTSIPAALEAVRAQLRAVPANGLGYGLLRYLSGQ--GQELA 2092 R GWFT+L+PVRL+P A + +L+A++ QLRA+P GLGYGLLRYL+G+ + LA Sbjct: 1324 RTVGWFTSLFPVRLSPVA---DLGESLKAIKEQLRAIPDKGLGYGLLRYLAGEESARVLA 1380 Query: 2093 QGAQPQITFNYLGHFDHR------IEPAGWTLADEYAGAQRAADSRRRCLFEAIARVQQG 2146 Q +ITFNYLG FD + ++PAG E AGA+ + RV G Sbjct: 1381 GLPQARITFNYLGQFDAQFDEMALLDPAG-----ESAGAEMDPGAPLDNWLSLNGRVFDG 1435 Query: 2147 RLQWQWTYCKDLHAAAEMRALQERLRTEL 2175 L W++ + ++R L + EL Sbjct: 1436 ELSIDWSFSSQMFGEDQVRRLADDYVAEL 1464 Score = 730 bits (1885), Expect = 0.0, Method: Compositional matrix adjust. Identities = 562/1409 (39%), Positives = 740/1409 (52%), Gaps = 128/1409 (9%) Query: 2194 LSPMQAGMFFHSSMNAGDGAYINQLRLDLAGV-DEVRLEAVWRDAVRRHPILRTGFRQ-Q 2251 LS Q M+F + AY L + GV D+ L+ + V RH LRT F + Sbjct: 6 LSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRFEEVD 65 Query: 2252 GDAPEQWVAQPVLHWRALDLSGQPPQQQAQLEQIAAAELARGFDLAQPGLMRLVLAKLGE 2311 G A + +A L D +G +A L Q A E+ + FDLA+ L+R+ L L Sbjct: 66 GQARQTILANMPLRIVLEDCAGA---SEATLRQRVAEEIRQPFDLARGPLLRVRLLALAG 122 Query: 2312 GRHHLIWTRHHLLLDGWSSAQLFAEIVRAYA----GEE--IAAPTLAYRHYIDW----LQ 2361 H L+ T+HH++ DGWS + E+++AYA GE+ +A TL Y Y W L Sbjct: 123 QEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWHRAWLD 182 Query: 2362 ARDGAAARDFWRAQLQHLEEPTL-LAGALPRPREDASGHAEHLAAISPAQW-QALCQAAK 2419 + +GA D+WR +L E+P L L RP + ASG + L P + L A+ Sbjct: 183 SGEGARQLDYWRERL-GAEQPVLELPADRVRPAQ-ASGRGQRLDMALPVSLSEELLACAR 240 Query: 2420 AMRITPGTLLQGAWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTLPLAVRL 2479 +TP LL ++ ++L+R GQS + GV +A+R +E +G F+NT L ++ Sbjct: 241 REGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANR--NRAEVERLIGFFVNTQVLRCQV 298 Query: 2480 HAPQDCSDWLR--------ALLHQNLAM----------REFAHAPLYEI--QRWSGRAGQ 2519 A D L A HQ+L R +H+PL+++ SG Sbjct: 299 DAGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVMYNHQSGERQD 358 Query: 2520 ALFDSILVLENYPMDEAIDRAADYGLHLSGLRLHEQTSYPLTVVATAQDGLSLRLGYDRS 2579 A D L +E++ D A AA + L L DGL L Y Sbjct: 359 AQVDG-LHIESFAWDGA---AAQFDLALD--------------TWETPDGLGAALTYATD 400 Query: 2580 RFGAHQVAQLA-DWLAQALVTLTTAGARLGDCALGSATQRQQALD-WSLNGQRFDGQEPV 2637 F A V ++A W L A + + A +R Q L+ W+ + Q V Sbjct: 401 LFEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGV 460 Query: 2638 HRLFEQQASRRPDAIALQADGAHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAA 2697 HRLFE+Q R P A AL Y +LN AN LA L GVG D +V + ERS Sbjct: 461 HRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIE 520 Query: 2698 MVTALLAVLKAGAAYLPLDPDYPAERLAWMLEDARPACLLSHRGLHHRLALPDTLLLELE 2757 MV AL+A+LKAG AY+P+DP+YP ER A+MLED+ LLS H +L L + Sbjct: 521 MVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQS--HLKLPLAQGVQRIDL 578 Query: 2758 DQLPGSQRGDDPQHNPQPPLHGEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYA 2817 DQ + + ++NP L+GE+LAYVIYTSGSTG+PKGAGN H AL NRL WMQQAY Sbjct: 579 DQ-ADAWLENHAENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYG 637 Query: 2818 LQEGDAVLQKTPFGFDVSVWEFLWPLMTGARLVMAPPGAHRDPAELAALIREQGVSTLHF 2877 L GD VLQKTPF FDVSVWEF WPLM+GARLV+A PG HRDPA+L ALI +GV TLHF Sbjct: 638 LGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLHF 697 Query: 2878 VPSMLQAFLASGQAAACTSLRQVICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDV 2937 VPSMLQAFL +CTSL++++CSGEAL A+A+ Q FA LPQA L+NLYGPTEAAIDV Sbjct: 698 VPSMLQAFLQDEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTEAAIDV 757 Query: 2938 THWTCQHGDRGPVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLT 2997 THW+C + VPIG+PI+ L +LD DL +P GV GELYL G GLARGY RPGLT Sbjct: 758 THWSCVEEGKDAVPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGYHQRPGLT 817 Query: 2998 AERFVASPFGQGERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALD 3057 AERFVASPF GER+YRTGDL R+R DG I+Y GR+DHQVK+RGLRIELGEIEA+LL Sbjct: 818 AERFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHP 877 Query: 3058 EVEEAVVVAHEHGAGPVLAGYVASRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPL 3117 V EA V+A + L GYV L LA LP+YMVPA L +PL Sbjct: 878 WVREAAVLAVDSRQ---LVGYVVLESEGGDWREALAAHLATSLPEYMVPAQWLALERMPL 934 Query: 3118 NANGKIDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHS 3177 + NGK+DRKALP P+ + + APQ ++E+R+A +W +L LE VG D+FF LGG S Sbjct: 935 SPNGKLDRKALPRPQAAAGQ-THVAPQNEMERRIAAVWADVLKLEEVGATDNFFALGGDS 993 Query: 3178 LLAASLVARLRYQGEAGVGVALPLRLVFAYPRLHEMAACIEGQAAIAAQQLPAAPAPLLQ 3237 +++ +V+R R G+ + +F + +A AA+ +Q P + +L Sbjct: 994 IVSIQVVSRCR-----AAGIQFTPKDLFQQQTVQGLARVARVGAAVQMEQGPVSGETVLL 1048 Query: 3238 PGQR-GAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVAR 3296 P QR + + QH +N S L ++A LE AL+ LV Sbjct: 1049 PFQRLFFEQPIPNRQH----------------WNQSLLLKPREALNAKALEAALQALVEH 1092 Query: 3297 HDILRTGFGE-DGD---GNPVATLH-PFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAAR 3351 HD LR F E DG + ATL + E D AL + Q RS Sbjct: 1093 HDALRLRFHETDGTWHAEHAEATLGGALLWRAEAVDRQALESLCEESQ-----RS----- 1142 Query: 3352 FALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPP 3411 L PLLR+ LV +A Q LLL IHH+V DG S +++E++ AY G P Sbjct: 1143 LDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLEDLQRAYQQSLRGE---AP 1199 Query: 3412 PLPLQYADYAAWQVAG-----AGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPAR---- 3462 LP + + + AW AG A ++ + +WR+ L G PA LP P A Sbjct: 1200 RLPGKTSPFKAW--AGRVSEHARGESMKAQLQFWRELLEGAPAE--LPCEHPQGALEQRF 1255 Query: 3463 ATHAGQRLRMHLPAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAG 3522 AT R L L A R + +LL + A ++ + SGA +V + G Sbjct: 1256 ATSVQSRFDRSLTERLLKQAPAAYRTQ---VNDLLLTALARVVCRWSGASSSLVQLEGHG 1312 Query: 3523 RSH----PDLERLVGFFVNVLPLRLRPQA 3547 R DL R VG+F ++ P+RL P A Sbjct: 1313 REELFADIDLSRTVGWFTSLFPVRLSPVA 1341 Score = 217 bits (552), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 185/508 (36%), Positives = 264/508 (51%), Gaps = 47/508 (9%) Query: 3247 LSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGE 3306 LS AQ R+W + +L E ++AAY++ + L + GV+D L+QA LV RH+ LRT F E Sbjct: 6 LSHAQQRMWFLWKL--EPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRF-E 62 Query: 3307 DGDGNPVATL---HPFDFSLEQHDLA-ALPPPQRDLQLDRLRRSHAAARFALRQPPLLRA 3362 + DG T+ P LE D A A R + +R+ F L + PLLR Sbjct: 63 EVDGQARQTILANMPLRIVLE--DCAGASEATLRQRVAEEIRQP-----FDLARGPLLRV 115 Query: 3363 ALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQYADYAA 3422 L+ LA Q+ VL++ HHIV+DGWS+ +M++E+ AY+A + G PL LQYADYAA Sbjct: 116 RLLALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAA 175 Query: 3423 WQVA----GAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQRLRMHLPAHL 3478 W A G G+R L+ +WR+ L LP+ R PA+A+ GQRL M LP L Sbjct: 176 WHRAWLDSGEGARQLD----YWRERLGAEQPVLELPADRVRPAQASGRGQRLDMALPVSL 231 Query: 3479 RSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRSHPDLERLVGFFVNV 3538 + A ARREGVT + +LLASF LL + SG D VG +A R+ ++ERL+GFFVN Sbjct: 232 SEELLACARREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRAEVERLIGFFVNT 291 Query: 3539 LPLRLRPQALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQVL 3598 LR + A +F L + A+ A HQ+ F+++V+A R +PL QV+ Sbjct: 292 QVLRCQVDA---GLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVM 348 Query: 3599 FVLQNTPRAALALPGVRAELLEPLENWSKFDLALFVEDHAEAGDAEDGPGWRADWVYADA 3658 + Q+ R + G+ E ++FDLAL + + DG G A YA Sbjct: 349 YNHQSGERQDAQVDGLHIESFAWDGAAAQFDLAL------DTWETPDGLG--AALTYATD 400 Query: 3659 LFDAATVAALGRDWQRLLEQVLASPWTPLDAALPSSPSD-----------TKAEVPSQVL 3707 LF+A TV + R WQ LL +L +P +D +LP ++ T AE P Q Sbjct: 401 LFEARTVERMARHWQNLLRGMLENPQASVD-SLPMLDAEERGQLLEGWNATAAEYPLQRG 459 Query: 3708 LDEITDMTLTSSSAPAAPAGNAAASKLD 3735 + + + + + P APA +LD Sbjct: 460 VHRLFEEQVERT--PTAPALAFGEERLD 485 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 250/948 (26%), Positives = 385/948 (40%), Gaps = 136/948 (14%) Query: 48 ASGERRFSFAQLDLRARAYAAAFQQRCPQGARVLLV-LENDEHYVQAFLGCLYAGMVAVP 106 A GE R +A+L+ RA A A +R R++ V +E V A + L AG VP Sbjct: 478 AFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYVP 537 Query: 107 VFP--PESVRPQHLKRLAGIAADAQAACVVLPEPLRQTCAQAALFGAAELLAAEQVADAD 164 V P PE +R A + D+ ++ L+ AQ + + +Q ADA Sbjct: 538 VDPEYPE-------ERQAYMLEDSGVQLLLSQSHLKLPLAQGV-----QRIDLDQ-ADAW 584 Query: 165 AVHWREHTP----QPQDIAFLQYTSGSTSAPKGVMVSHGNLMANEAAISACMRVREDDIF 220 + E+ P +++A++ YTSGST PKG H L + + D Sbjct: 585 LENHAENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTV 644 Query: 221 VTWLPLYHDMGLIGGLLQGLVRGLKTVLCSPRYFLERPLRWLELVARHRGTVSGGPDFAY 280 + P D+ + L+ G + V+ +P + P + + L+ R G D + Sbjct: 645 LQKTPFSFDVS-VWEFFWPLMSGARLVVAAPGDHRD-PAKLVALINRE------GVDTLH 696 Query: 281 RLCVERIKPAQLQGVDL---SSWRVAFCGAEPLRADTFPAFIERFCAAGFSADAAYPCYG 337 V + A LQ D+ +S + C E L AD + AG Y YG Sbjct: 697 --FVPSMLQAFLQDEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGL-----YNLYG 749 Query: 338 LAEATLIVSGGPPHGAHATAFHTAELAA--GRAVEGGPDDTRLVAC----GDIAPHHEVR 391 EA + V+ H + + A GR + + C GD+ P V Sbjct: 750 PTEAAIDVT-------HWSCVEEGKDAVPIGRPIAN-------LGCYILDGDLEP---VP 792 Query: 392 IIEDGRVQQDGAVGEIEVCGPSVTQGYWQRPQQSAAAFVERD---GRRWLRTGDLGFLR- 447 + G +GE+ + G + +GY QRP +A FV G R RTGDL R Sbjct: 793 V---------GVLGELYLAGRGLARGYHQRPGLTAERFVASPFVAGERMYRTGDLARYRA 843 Query: 448 DGQLYIAGRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAE 507 DG + AGR + +RG + +IE + + VR+ A AV++ + G V E Sbjct: 844 DGVIEYAGRIDHQVKLRGLRIELGEIEARLLEH-PWVREA--AVLAVDSRQLVGY-VVLE 899 Query: 508 ISRGMQKLAAPGVIASAIAEAVAQSSLEAPQVVILLNPGGLPKTSSGKLQRSACRSGWRN 567 G + A +A+++ E + + A + +P + +GKL R A Sbjct: 900 SEGGDWREALAAHLATSLPEYMVPAQWLALE--------RMPLSPNGKLDRKALPR---- 947 Query: 568 GELDAWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQADFFR 627 P A G +A PQ ++E +AA+W LK G +FF Sbjct: 948 -----------------PQAAAGQTHVA--PQNEMERRIAAVWADVLKLEEVGATDNFFA 988 Query: 628 SGGSSLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPLPACVDG 687 GG S+ ++QVV+ ++FTP LF T+ +A + GA V G Sbjct: 989 LGGDSIVSIQVVSRCRAA-GIQFTPKDLFQQQTVQG----LARVARVGAAVQMEQGPVSG 1043 Query: 688 QSE-FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRT 746 ++ P Q L+ Q P+ +N + +L L +ALE AL L H ALR Sbjct: 1044 ETVLLPF----QRLFFE-QPIPNRQHWNQSLLLKPREALNAKALEAALQALVEHHDALRL 1098 Query: 747 LFPLRDGTPVQQVLDIDEARPMLLRSD-LRRQPADKRAQAAASALQRFHAQAFRLDSETP 805 F DGT + + +L R++ + RQ + + + +L L Sbjct: 1099 RFHETDGTWHAEHAEATLGGALLWRAEAVDRQALESLCEESQRSLD--------LADGPL 1150 Query: 806 LRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGD 865 LR++LV + RL L IHH+ DG S I+L++L AY+ G AP P + Sbjct: 1151 LRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLEDLQRAYQQSLRGEAPRLPG---KTSP 1207 Query: 866 YAVWQRQRSQPGSPEFQR-QLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSA 924 + W + S+ E + QL +WR LEGAPA LP + P+ A + R Sbjct: 1208 FKAWAGRVSEHARGESMKAQLQFWRELLEGAPA--ELPCEHPQGALEQRFATSVQSRFDR 1265 Query: 925 ALSTALRKLA-ASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADR 971 +L+ L K A A+ + +L + R SG S V G R Sbjct: 1266 SLTERLLKQAPAAYRTQVNDLLLTALARVVCRWSGASSSLVQLEGHGR 1313 >all2648_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1063 Score = 778 bits (2008), Expect = 0.0, Method: Composition-based stats. Identities = 442/1068 (41%), Positives = 609/1068 (57%), Gaps = 46/1068 (4%) Query: 2192 YALSPMQAGMFFHSSMNAGDGAYINQLRLDLAG-VDEVRLEAVWRDAVRRHPILRTGFR- 2249 Y LSPMQAGM FH+ G Y Q + G ++ W+ V RH +LRT F Sbjct: 9 YELSPMQAGMLFHTLYAPNSGVYFEQRSCLIRGNLNLPAFRQAWQRVVERHSVLRTAFHY 68 Query: 2250 QQGDAPEQWVAQPV-LHWRALDLSG-QPPQQQAQLEQIAAAELARGFDLAQPGLMRLVLA 2307 + + P Q V V L W+ LD G + Q+A+L + + GF+L QP LMR + Sbjct: 69 SELEKPLQVVYDYVELPWQELDWCGVEATVQKAKLTEFLECDCNSGFNLQQPPLMRCAVI 128 Query: 2308 KLGEGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAG----EEIAAPT-LAYRHYIDWLQA 2362 +L ++ IW+ HHLL+DGW + L E+ Y E++ P+ + Y +YI WLQ Sbjct: 129 RLEANKYQFIWSHHHLLMDGWCNGILLTEVFTLYKAFCQSEDVTLPSPIPYGNYILWLQQ 188 Query: 2363 RDGAAARDFWRAQLQHLEEPTLLAGALPRPREDASGHAEHLAAISPAQWQALCQAAKAMR 2422 ++ A FWR QLQ PT+L + + S + ++ Q + L + R Sbjct: 189 QNPEQAESFWRKQLQDFTAPTVLGNKI----NNQSSIFSQQSKVNSQQTEQLQNFVRQHR 244 Query: 2423 ITPGTLLQGAWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTLPLAVRLHAP 2482 +T L+QGAWAL+L R G++ V FG TV+ RP EL +ES +GLFINTLP+ V ++ Sbjct: 245 LTLNILVQGAWALLLSRYSGENNVLFGTTVSGRPPELPQVESIVGLFINTLPVRVDVNGE 304 Query: 2483 QDCSDWLRALLHQNLAMREFAHAPLYEIQRWSGRA-GQALFDSILVLENYPMD-EAIDRA 2540 WL+ L Q + +++++ L +IQ WS G +LF+S+LV ENYP+ E++ + Sbjct: 305 MQIIPWLQQLQAQQVEREQYSYSSLVDIQSWSSVPRGTSLFESLLVFENYPVSIESVIKT 364 Query: 2541 ADYGLHLSGLRLHEQTSYPLTVVATAQDGLSLRLGYDRSRFGAHQVAQLADWLAQALVTL 2600 D L + + E+T+YPLT+ + L ++ YD S F A +++L L L+++ Sbjct: 365 FDQTLQIEDTQGFEKTNYPLTLTVIPGEELLFKVSYDVSYFDAATISRLLGHLETLLMSM 424 Query: 2601 TT-AGARLGDCALGSATQRQQAL-DWSLNGQRFDGQEPVHRLFEQQASRRPDAIALQADG 2658 RL ++ + ++Q L DW+ Q + Q +H+LFE Q R PDAIAL Sbjct: 425 VNEPEQRLSQLSMLTPQEKQLILKDWNQTTQAYPNQ-CIHQLFEAQVERTPDAIALVFGE 483 Query: 2659 AHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAAYLPLDPD 2718 TY +LN AN LA LQ GV P+ +V + ERS M LL ++KAG AY+P+DP+ Sbjct: 484 ECLTYRELNNKANQLAHYLQQLGVKPEILVGICLERSLEMTVCLLGIIKAGGAYVPIDPE 543 Query: 2719 YPAERLAWMLEDARPACLLSHRGLHHRLALPDTLLLELEDQLPGSQRGDDPQHNPQPPLH 2778 YP ER+A+MLED++ L+ L ++ T + ++ + R P NP + Sbjct: 544 YPQERIAYMLEDSQVKVFLTQEQLLAQIPQNQTHKICIDTEWDKISR--QPNTNPDSGVK 601 Query: 2779 GEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYALQEGDAVLQKTPFGFDVSVWE 2838 ++LAYVIYTSGSTG+PKG N+H+ + NRL WMQ+ Y + D++LQKTPF FDVSVWE Sbjct: 602 LDNLAYVIYTSGSTGKPKGVMNTHQGICNRLLWMQETYQINSTDSILQKTPFSFDVSVWE 661 Query: 2839 FLWPLMTGARLVMAPPGAHRDPAELAALIREQGVSTLHFVPSMLQAFLASGQAAACTSLR 2898 F W L+TGARLV+A PG HRD A L LI ++ ++ LHFVPSML+ FL SG CTSL+ Sbjct: 662 FFWTLLTGARLVIAKPGGHRDSAYLINLIIQEQITILHFVPSMLRIFLESGNVEKCTSLK 721 Query: 2899 QVICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDVTHWTC-QHGDRGPVPIGQPIS 2957 +VICSGEAL + ++QF L+NLYGPTEAAIDVT W C +H + VPIG+PI+ Sbjct: 722 RVICSGEALSLDLQNQFLERF-DCELYNLYGPTEAAIDVTFWQCRKHTNLKTVPIGRPIA 780 Query: 2958 GLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLTAERFVA-------------- 3003 +LD L +P GV GELY+GG G+ARGYL RP LTAERF++ Sbjct: 781 NTHIYILDQHLQPVPIGVPGELYIGGAGVARGYLNRPELTAERFISYSDLGSIGYLTPMP 840 Query: 3004 -SPFGQGERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALDEVEEA 3062 +P LY+TGD R+ DG I+YLGRLD+QVKIRG RIELGEIE L EV+ A Sbjct: 841 HAPCPIPHALYKTGDRARYLRDGTIEYLGRLDNQVKIRGFRIELGEIETVLSQHSEVQAA 900 Query: 3063 VVVAHEHGAG-PVLAGYVASRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPLNANG 3121 +VV E G L Y+ S + D L+Q LA LPDYM+P+ L LPL NG Sbjct: 901 IVVVTEDTTGDKRLVAYIVSENPEITD---LRQYLAKNLPDYMIPSQFITLDALPLTPNG 957 Query: 3122 KIDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHSLLAA 3181 K+DR+ALP P+ + AP+ E+ L IWQ +L L VG D+FF LGGHSL Sbjct: 958 KVDRRALPKPQFKTSSHT-IAPRTPTEELLLNIWQNILNLNSVGITDNFFALGGHSL--- 1013 Query: 3182 SLVARLRYQGEAGVGVALPLRLVFAYPRLHEMAACIEGQAAIAAQQLP 3229 LV RL Q + GV + LR +F P + E+A I +P Sbjct: 1014 -LVIRLVSQIQQVFGVDISLRQIFENPTIAELATLINSSKLSLYSSIP 1060 Score = 355 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 302/1085 (27%), Positives = 500/1085 (46%), Gaps = 91/1085 (8%) Query: 691 FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPL 750 + L+ Q G+ P+S Y + G L + A A + RH+ LRT F Sbjct: 9 YELSPMQAGMLFHTLYAPNSGVYFEQRSCLIRGNLNLPAFRQAWQRVVERHSVLRTAFHY 68 Query: 751 RD-GTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAA--ASALQRFHAQAFRLDSETPLR 807 + P+Q V D E L +L + Q A L+ F L +R Sbjct: 69 SELEKPLQVVYDYVE----LPWQELDWCGVEATVQKAKLTEFLECDCNSGFNLQQPPLMR 124 Query: 808 AMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYA 867 +++LEA+ ++ HH+ DGW GI+L E+ Y+A C + P+ + G+Y Sbjct: 125 CAVIRLEANKYQFIWSHHHLLMDGWCNGILLTEVFTLYKAFCQSEDVTLPS-PIPYGNYI 183 Query: 868 VWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSAALS 927 +W +Q++ PE + +WR +L+ A PT + + ++++ + Sbjct: 184 LWLQQQN----PE--QAESFWRKQLQDFTA----PTVLGNKINNQSSIFSQQSKVNSQQT 233 Query: 928 TALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRR--QTQALVAYLIN 985 L+ +TL V + L L R SG++++ G + R Q +++V IN Sbjct: 234 EQLQNFVRQHRLTLNILVQGAWALLLSRYSGENNVLFGTTVSGRPPELPQVESIVGLFIN 293 Query: 986 VQVVRTRIDERSDFLALMRQVQ-QAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKC 1044 VR ++ + ++Q+Q Q V+ Q +LV V LF+ Sbjct: 294 TLPVRVDVNGEMQIIPWLQQLQAQQVEREQ----YSYSSLVDIQSWSSVPRGTSLFESLL 349 Query: 1045 TQQQ---AIATVRRMGGLDMRVE-LQANAESHFDLSLDFTDADEGIDILLAYAPALFDAE 1100 + +I +V + +++E Q ++++ L+L +E + ++Y + FDA Sbjct: 350 VFENYPVSIESVIKTFDQTLQIEDTQGFEKTNYPLTLTVIPGEE-LLFKVSYDVSYFDAA 408 Query: 1101 TVAGFAGLLQALAQQVVAAPALALADLQAFPP------ISAADQVLQ--PAEDVAACWRR 1152 T++ G L+ L +V P L+ L P + +Q Q P + + + Sbjct: 409 TISRLLGHLETLLMSMVNEPEQRLSQLSMLTPQEKQLILKDWNQTTQAYPNQCIHQLFEA 468 Query: 1153 QALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGML 1212 Q PDA+AL G + ++ +L + + LA L G PE V + R ++ +L Sbjct: 469 QVERTPDAIALVFGEECLTYRELNNKANQLAHYLQQLGVKPEILVGICLERSLEMTVCLL 528 Query: 1213 AVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTA 1272 ++ G AYVP+DP+ P ER+A+ L+DS + L + Q A + Q + ++ Sbjct: 529 GIIKAGGAYVPIDPEYPQERIAYMLEDSQVKVFLTQEQLL-AQIPQNQTHKICIDTEWDK 587 Query: 1273 PASPWTPFP---VHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAARS 1329 + P V AY+IYTSGSTG+PKGV+ T G+ N + + E + + S Sbjct: 588 ISRQPNTNPDSGVKLDNLAYVIYTSGSTGKPKGVMNTHQGICNRLLWMQETYQI-NSTDS 646 Query: 1330 MAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQ 1389 + + + D+ + L +G +L + D + + + +L VPS L+ Sbjct: 647 ILQKTPFSFDVSVWEFFWTLLTGARLVIAKPGGHRDSAYLINLIIQEQITILHFVPSMLR 706 Query: 1390 ALLHAARPEQVLPRHTLVLGGEATGWPL----LERIAALQPACRVLNHYGPSETTVGVLA 1445 L + E+ ++ GEA L LER C + N YGP+E + V Sbjct: 707 IFLESGNVEKCTSLKRVICSGEALSLDLQNQFLERFD-----CELYNLYGPTEAAIDVTF 761 Query: 1446 QEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALT 1505 + + V P+G +A ++LD+ L+ P+G GELY+GGAG+ARGY R LT Sbjct: 762 WQCRKHTNLKTV-PIGRPIANTHIYILDQHLQPVPIGVPGELYIGGAGVARGYLNRPELT 820 Query: 1506 AERFVAH---------------PFASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGH 1550 AERF+++ P LY++GDRARYL DG+IE+LGR+D+QVKIRG Sbjct: 821 AERFISYSDLGSIGYLTPMPHAPCPIPHALYKTGDRARYLRDGTIEYLGRLDNQVKIRGF 880 Query: 1551 RVEPGEVRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAAD 1610 R+E GE+ + +L V AA++ + D +L +IV + D R LA + Sbjct: 881 RIELGEI-ETVLSQHSEVQAAIVVV-TEDTTGDKRLVAYIVSENPEITD---LRQYLAKN 935 Query: 1611 LPDYMLPT-LTPVPALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQ 1669 LPDYM+P+ + ALPLT NGK+DR+AL P+ Q + + AP+ Sbjct: 936 LPDYMIPSQFITLDALPLTPNGKVDRRAL----------PKPQF------KTSSHTIAPR 979 Query: 1670 GELEHKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARARKE-GLRIAPKAMMEKQ 1728 E L IW +L L VG DNFF LGG S+L +++V++ ++ G+ I+ + + E Sbjct: 980 TPTEELLLNIWQNILNLNSVGITDNFFALGGHSLLVIRLVSQIQQVFGVDISLRQIFENP 1039 Query: 1729 TVAAI 1733 T+A + Sbjct: 1040 TIAEL 1044 Score = 99.4 bits (246), Expect = 2e-19, Method: Composition-based stats. Identities = 75/344 (21%), Positives = 151/344 (43%), Gaps = 18/344 (5%) Query: 3265 DAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGEDGDGNPVATLHPF-DFSL 3323 ++ Y + ++ G ++ QA + +V RH +LRT F P+ ++ + + Sbjct: 27 NSGVYFEQRSCLIRGNLNLPAFRQAWQRVVERHSVLRTAFHYSELEKPLQVVYDYVELPW 86 Query: 3324 EQHDLAALPPPQRDLQLDRLRRSHAAARFALRQPPLLRAALVRLAPQQQVLLLAIHHIVA 3383 ++ D + + +L + F L+QPPL+R A++RL + + + HH++ Sbjct: 87 QELDWCGVEATVQKAKLTEFLECDCNSGFNLQQPPLMRCAVIRLEANKYQFIWSHHHLLM 146 Query: 3384 DGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQYADYAAWQVAGAGSRMLEDSIAWWRDT 3443 DGW +++ E+ Y A + P P+ Y +Y W + E + ++WR Sbjct: 147 DGWCNGILLTEVFTLYKAFCQSEDVTLPS-PIPYGNYILW----LQQQNPEQAESFWRKQ 201 Query: 3444 LAGVPATPYLPSTRPCPARATHAGQRLRMHLPAHLRSGVQALARREGVTAYAVLLASFAW 3503 L A L + +++ Q+ +++ + +Q R+ +T ++ ++A Sbjct: 202 LQDFTAPTVLGNK--INNQSSIFSQQSKVN--SQQTEQLQNFVRQHRLTLNILVQGAWAL 257 Query: 3504 LLHQRSGAGDFVVGTDVAGR--SHPDLERLVGFFVNVLPLRLRPQALAPRASFAAWLRHC 3561 LL + SG + + GT V+GR P +E +VG F+N LP+R+ WL+ Sbjct: 258 LLSRYSGENNVLFGTTVSGRPPELPQVESIVGLFINTLPVRVDVNG---EMQIIPWLQQ- 313 Query: 3562 ADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQVLFVLQNTP 3605 + + ++ + +V+ R L + L V +N P Sbjct: 314 --LQAQQVEREQYSYSSLVDIQSWSSVPRGTSLFESLLVFENYP 355 >all2649 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1583 Score = 767 bits (1980), Expect = 0.0, Method: Compositional matrix adjust. Identities = 521/1554 (33%), Positives = 784/1554 (50%), Gaps = 103/1554 (6%) Query: 686 DGQSEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALR 745 + +E PL+ AQ+ LW Q+ P ++YN+A L G+L++ L +L + RH +LR Sbjct: 45 NNNTELPLSLAQERLWFLHQINPSDSSYNIAISWQLAGKLEISTLLASLQTIIQRHESLR 104 Query: 746 TLFPLRDGTPVQQVL-DIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSET 804 T F ++G P Q++ +ID P++ DL+ P ++AQ A + +Q F L Sbjct: 105 TAFLSQEGKPYQKIAANIDLQLPII---DLQGLPPQQQAQTAQDLAKLEASQPFDLTQAP 161 Query: 805 PLRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPG 864 +R L++L + L L +HHI ADGWS GI+L EL Y A PS PAL Q Sbjct: 162 LMRVKLIRLAPNQATLLLTLHHIIADGWSRGILLRELATCYRAFINDEQPSLPALSNQYA 221 Query: 865 DYAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSA 924 D+A+WQR+ Q E QL YW+ +L P L LPTD PR A + L Sbjct: 222 DFALWQRECLQ--REEMAAQLAYWQQKLAKLPTL-ELPTDYPRTALQKFNGKTESYLLPK 278 Query: 925 ALSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQALVAYLI 984 LS +L++L+ QGVTL+ +LA F + L R Q ++ +G P A+R R+Q Q+L+ + + Sbjct: 279 TLSESLKQLSKQQGVTLFMLLLAAFKVLLHRYCQQDEIVLGVPSANRDRQQIQSLIGFFV 338 Query: 985 NVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKC 1044 N V+RT + E F L+ +++ EA +Q++P +V ALQ ER NPL QV Sbjct: 339 NTLVLRTDLSENPTFTTLLERIRTTAAEAFEYQEIPFAKVVEALQIERDLSHNPLVQVMF 398 Query: 1045 TQQQAIATVRRMGGLDMRV---ELQ----ANAESHFDLSLDFTDADEGIDILLAYAPALF 1097 Q ++ LD+++ E+Q + FDL+ + +G+ +++ Y LF Sbjct: 399 QVQNEAYQLQNDSQLDLQIPDLEIQQTWVETGATKFDLTCHIVERSQGLLVVMEYCTDLF 458 Query: 1098 DAETVAGFAGLLQALAQQVVAAPALALADLQAFPPISAADQVL----QPAEDVAACWRRQ 1153 +T+ L+ + +V P+ ++++ P Q+L Q D W Q Sbjct: 459 QQQTITRMIQHLRVILAAIVENPSRKISEIPILTP-QEQHQILVEWNQTQVDYPQKWLHQ 517 Query: 1154 ALAQ-----PDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFV 1208 + PD++A+ Q ++ +L +++ LA L G G ES V +Y R + + Sbjct: 518 LFEEQVQRTPDSIAVCYQEQTLTYQELNSKVNQLAHHLQKLGVGCESLVGIYLERSPELI 577 Query: 1209 CGMLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEA 1268 +LAVL G AY+PLD +LP ERLA+ L D+ R +L S G + E Sbjct: 578 IALLAVLKAGGAYIPLDNKLPPERLAYMLGDAQPRIILTMAASVTGLPDYQGTVICLDED 637 Query: 1269 AGTAPASPWTPFP--VHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAA 1326 + +P P V AY+IYTSGSTG+PKGV++T GLANY+ ++ + Sbjct: 638 WQSIAQNPTENLPNIVTGENLAYIIYTSGSTGKPKGVMLTHRGLANYLQWAIQTYPVDLG 697 Query: 1327 ARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHE-HAVDVLKIVP 1385 + + S ++ D T+LY L G+ + L+ A + + L ++K+ P Sbjct: 698 V-GVPVQSAISFDATITSLYTPLLVGKAVILLPE--AEEIEALKNALSSARNFSLVKLTP 754 Query: 1386 SHLQALLHAARPEQVLPRHT-------LVLGGEATGWPLLERIAALQPACRVLNHYGPSE 1438 +HL L Q+LP+ ++GGEA LE + P +++N YGP+E Sbjct: 755 AHLSIL------SQLLPQKVPAGYPQAFIIGGEALTEQHLEFWRSYFPQTKLINEYGPTE 808 Query: 1439 TTVGVLAQEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGY 1498 T VG +A+ +P+G +A + ++LDR L+ P+G GELY+GGAG+ARGY Sbjct: 809 TVVGCCIYDASQGKSSKGNVPIGRPIANTRLYILDRYLQPVPIGVPGELYIGGAGVARGY 868 Query: 1499 HGRAALTAERFVAHPFASGQR------LYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRV 1552 R LTAERF++ + LY+ GDRARYL DG+IE+LGR+DDQVKIRG RV Sbjct: 869 LNRPELTAERFISQQSTVNSQQSTVNTLYKPGDRARYLSDGTIEYLGRLDDQVKIRGFRV 928 Query: 1553 EPGEVRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAADLP 1612 E GE+ + +L+ V AV+ L Q QL ++V V +R LA LP Sbjct: 929 ELGEI-EAILKAHPSVQEAVVILQKV-HPQSSQLVAYLVGNQQTV----DFRQYLATKLP 982 Query: 1613 DYMLPT-LTPVPALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGE 1671 YMLP+ + LPLT NGK+D+Q L A A +QV AP+ Sbjct: 983 AYMLPSAFVWLEQLPLTTNGKVDKQQLP---APAAKPESEQV-------------APRNA 1026 Query: 1672 LEHKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQTVA 1731 +E L IW E+L + VG DNFFE GGDSIL++++VA+A G+++ PK + + QT+A Sbjct: 1027 IEATLVEIWTEILGV-SVGIHDNFFERGGDSILSIQMVAKANNAGIKLTPKQLFQHQTIA 1085 Query: 1732 AIVAAGAVQGMLAATPAPAVVAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLN-APGLD 1790 + + A T A +PLTP+QHW FEQ ++NQ+VLL A L+ Sbjct: 1086 ELATVIEI----APTTQVEQGIATGIVPLTPIQHWLFEQNLHKWDYFNQAVLLEVAADLE 1141 Query: 1791 AGVLRRALALLAQRHESLRLRFVQEG--GQWRQRRGPALLPLEIID---------GDEPG 1839 L++A+ L H+ LR F+ G W Q P EI + Sbjct: 1142 VDYLKQAIEELVLHHDVLRSCFINSSLDGAWEQDIIPTFENGEIFTVVDLNGFSANQQTQ 1201 Query: 1840 AIAAAGELVQRSLDLAQGPLMAAAWIRLDAQGKQGRLLLAGHHLVVDGVSWRVLLDDLAG 1899 I + +Q SLDLAQG L A +L + RLL HHLVVDG+SWR+LL+DL Sbjct: 1202 QIESVASQLQASLDLAQGILFKVALFKL-GDNQNHRLLFIIHHLVVDGISWRILLEDLVT 1260 Query: 1900 LYHTLQQGGTPAELP-PATDLYTWSQALRAHAQRPAVTDQLAYWRSVV--DTPEPPLADA 1956 Y L+ T +L T W+Q L +A+ V Q W ++ P+ PL Sbjct: 1261 AYQQLKAKQTSIKLSLKTTSFREWAQNLVNYAESDQVVAQFKTWLEILPKQLPQLPLDKI 1320 Query: 1957 TANLAGRAADAGFVLDADATARLLALGAHADPAVRVAPQDLLLAVLARVLCEWSGRDSLL 2016 A++A + D ++ AL A + D+LL LA +W+ ++S+L Sbjct: 1321 GKGDNNIASEAEIQVKLD-ISQTRALIEAVPKAYQTQINDVLLTALALTYSQWTQQNSVL 1379 Query: 2017 FELEGHGREDIPGGLDVSRATGWFTALYPVRLAPGATSTSIPAALEAVRAQLRAVPANGL 2076 +LE HGRED+ ++++R GWFT ++PV L + ++ L+ V+ +LR +P G+ Sbjct: 1380 IDLETHGREDLFANINITRTVGWFTTIFPVFLELKNIN-NLEENLKYVKERLREIPQKGI 1438 Query: 2077 GYGLLRYLSGQGQELAQGAQ--PQ--ITFNYLGHFDHRIEPAGWT--LADEYAGAQRAAD 2130 YGLLRYL+ Q+++Q Q PQ I+FNYLG D GW LA E G Sbjct: 1439 SYGLLRYLNP-NQQISQTLQSLPQSAISFNYLGQLD-LFTSQGWILGLAKESTGLSSHPL 1496 Query: 2131 SRRRCLFEAIARVQQGRLQWQWTYCKDLHAAAEMRALQERLRTELMRWIEALEA 2184 ++RR + A + Q +LQ QW Y ++LH + L ++ L I+ +A Sbjct: 1497 NQRRYVLNINAWIAQSQLQIQWRYSRNLHDTTTIENLAQQFIKTLQAIIQHCQA 1550 Score = 523 bits (1346), Expect = e-147, Method: Compositional matrix adjust. Identities = 451/1447 (31%), Positives = 681/1447 (47%), Gaps = 121/1447 (8%) Query: 2163 EMRALQERLRTELMRWIEALEARAASDAAYALSPMQAGMFFHSSMNAGDGAYINQLRLDL 2222 E RAL E+L + + + R ++ LS Q ++F +N D +Y + L Sbjct: 22 EKRALLEKLLRQKANSSQTIPPRN-NNTELPLSLAQERLWFLHQINPSDSSYNIAISWQL 80 Query: 2223 AGVDEVR-LEAVWRDAVRRHPILRTGFRQQGDAPEQWVAQPV-LHWRALDLSG-QPPQQQ 2279 AG E+ L A + ++RH LRT F Q P Q +A + L +DL G P QQ Sbjct: 81 AGKLEISTLLASLQTIIQRHESLRTAFLSQEGKPYQKIAANIDLQLPIIDLQGLPPQQQA 140 Query: 2280 AQLEQIAAAELARGFDLAQPGLMRLVLAKLGEGRHHLIWTRHHLLLDGWSSAQLFAEIVR 2339 + +A E ++ FDL Q LMR+ L +L + L+ T HH++ DGWS L E+ Sbjct: 141 QTAQDLAKLEASQPFDLTQAPLMRVKLIRLAPNQATLLLTLHHIIADGWSRGILLRELAT 200 Query: 2340 AY----AGEEIAAPTLA--YRHYIDW----LQARDGAAARDFWRAQLQHLEEPTL-LAGA 2388 Y E+ + P L+ Y + W LQ + AA +W+ +L L PTL L Sbjct: 201 CYRAFINDEQPSLPALSNQYADFALWQRECLQREEMAAQLAYWQQKLAKL--PTLELPTD 258 Query: 2389 LPRPREDASGHAEHLAAISPAQWQALCQAAKAMRITPGTLLQGAWALVLQRCCGQSAVAF 2448 PR + ++L Q +K +T LL A+ ++L R C Q + Sbjct: 259 YPRTALQKFNGKTESYLLPKTLSESLKQLSKQQGVTLFMLLLAAFKVLLHRYCQQDEIVL 318 Query: 2449 GVTVADRPAELEGIESTLGLFINTLPLAVRLHAPQDCSDWLR--------ALLHQNLAM- 2499 GV A+R + + I+S +G F+NTL L L + L A +Q + Sbjct: 319 GVPSANR--DRQQIQSLIGFFVNTLVLRTDLSENPTFTTLLERIRTTAAEAFEYQEIPFA 376 Query: 2500 ---------REFAHAPLYEIQ-RWSGRAGQALFDSILVLENYPMDEAIDRAADYGLHLSG 2549 R+ +H PL ++ + A Q DS L L+ P E + G Sbjct: 377 KVVEALQIERDLSHNPLVQVMFQVQNEAYQLQNDSQLDLQ-IPDLEIQQTWVETGATKFD 435 Query: 2550 LRLHEQTSYPLTVVATAQDGLSLRLGYDRSRFGAHQVAQLADWLAQALVTLTTAGAR-LG 2608 L H +V +Q GL + + Y F + ++ L L + +R + Sbjct: 436 LTCH--------IVERSQ-GLLVVMEYCTDLFQQQTITRMIQHLRVILAAIVENPSRKIS 486 Query: 2609 DCALGSATQRQQAL-DWSLNGQRFDG-QEPVHRLFEQQASRRPDAIALQADGAHWTYGQL 2666 + + + ++ Q L +W N + D Q+ +H+LFE+Q R PD+IA+ TY +L Sbjct: 487 EIPILTPQEQHQILVEW--NQTQVDYPQKWLHQLFEEQVQRTPDSIAVCYQEQTLTYQEL 544 Query: 2667 NAAANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAAYLPLDPDYPAERLAW 2726 N+ N LA LQ GVG +++V + ERS ++ ALLAVLKAG AY+PLD P ERLA+ Sbjct: 545 NSKVNQLAHHLQKLGVGCESLVGIYLERSPELIIALLAVLKAGGAYIPLDNKLPPERLAY 604 Query: 2727 MLEDARPACLLSHRGLHHRLALPD---TLLLELEDQLPGSQRGDDPQHNPQPPLHGEHLA 2783 ML DA+P +L+ LPD T++ ED +Q +P N + GE+LA Sbjct: 605 MLGDAQPRIILTMAA--SVTGLPDYQGTVICLDEDWQSIAQ---NPTENLPNIVTGENLA 659 Query: 2784 YVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYALQEGDAVLQKTPFGFDVSVWEFLWPL 2843 Y+IYTSGSTG+PKG +HR L N L+W Q Y + G V ++ FD ++ PL Sbjct: 660 YIIYTSGSTGKPKGVMLTHRGLANYLQWAIQTYPVDLGVGVPVQSAISFDATITSLYTPL 719 Query: 2844 MTGARLVMAPPGAHRDPAELAALIREQGVSTLHFVP---SMLQAFLASGQAAACTSLRQV 2900 + G +++ P A A AL + S + P S+L L A + Sbjct: 720 LVGKAVILLPE-AEEIEALKNALSSARNFSLVKLTPAHLSILSQLLPQKVPAGYP--QAF 776 Query: 2901 ICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDVTHWTCQHG--DRGPVPIGQPISG 2958 I GEAL + + + + PQ L N YGPTE + + G +G VPIG+PI+ Sbjct: 777 IIGGEALTEQHLEFWRSYFPQTKLINEYGPTETVVGCCIYDASQGKSSKGNVPIGRPIAN 836 Query: 2959 LRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLTAERFVA------SPFGQGERL 3012 R +LD L +P GV GELY+GG G+ARGYL RP LTAERF++ S L Sbjct: 837 TRLYILDRYLQPVPIGVPGELYIGGAGVARGYLNRPELTAERFISQQSTVNSQQSTVNTL 896 Query: 3013 YRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALDEVEEAVVVAHE-HGA 3071 Y+ GD R+ DG I+YLGRLD QVKIRG R+ELGEIEA L A V+EAVV+ + H Sbjct: 897 YKPGDRARYLSDGTIEYLGRLDDQVKIRGFRVELGEIEAILKAHPSVQEAVVILQKVHPQ 956 Query: 3072 GPVLAGYVASRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAP 3131 L Y+ Q +Q LA +LP YM+P+ L LPL NGK+D++ LPAP Sbjct: 957 SSQLVAYLVG----NQQTVDFRQYLATKLPAYMLPSAFVWLEQLPLTTNGKVDKQQLPAP 1012 Query: 3132 RLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHSLLAASLVARLRYQG 3191 E AP+ +E L +IW +LG+ VG D+FFE GG S+L+ +VA+ Sbjct: 1013 AAKPES-EQVAPRNAIEATLVEIWTEILGVS-VGIHDNFFERGGDSILSIQMVAKAN--- 1067 Query: 3192 EAGVGVALPLRLVFAYPRLHEMAACIEGQAAIAAQQLPAAPAPLLQPGQRGAQALLSPAQ 3251 G+ L + +F + + E+A IE AP ++ G L+P Q Sbjct: 1068 --NAGIKLTPKQLFQHQTIAELATVIE-----------IAPTTQVEQGIATGIVPLTPIQ 1114 Query: 3252 HRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGE---DG 3308 H WL ++ + D +N + L + ++ L+QA+ LV HD+LR+ F DG Sbjct: 1115 H--WLFEQNLHKWD--YFNQAVLLEVAADLEVDYLKQAIEELVLHHDVLRSCFINSSLDG 1170 Query: 3309 --DGNPVATLHPFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAARFALRQPPLLRAALVR 3366 + + + T + DL Q+ Q++ + S A L Q L + AL + Sbjct: 1171 AWEQDIIPTFENGEI-FTVVDLNGFSANQQTQQIESV-ASQLQASLDLAQGILFKVALFK 1228 Query: 3367 LAPQQQ-VLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQYADYAAWQ- 3424 L Q LL IHH+V DG S +++E++ AY L+ + L L+ + W Sbjct: 1229 LGDNQNHRLLFIIHHLVVDGISWRILLEDLVTAYQQLKAKQ--TSIKLSLKTTSFREWAQ 1286 Query: 3425 --VAGAGSRMLEDSIAWWRDTL-AGVPATPYLPSTRPCPARATHAGQRLRMHLPAHLRSG 3481 V A S + W + L +P P + A+ A ++++ + + R+ Sbjct: 1287 NLVNYAESDQVVAQFKTWLEILPKQLPQLPLDKIGKGDNNIASEAEIQVKLDI-SQTRAL 1345 Query: 3482 VQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGR----SHPDLERLVGFFVN 3537 ++A+ + VLL + A Q + ++ + GR ++ ++ R VG+F Sbjct: 1346 IEAVPKAYQTQINDVLLTALALTYSQWTQQNSVLIDLETHGREDLFANINITRTVGWFTT 1405 Query: 3538 VLPLRLR 3544 + P+ L Sbjct: 1406 IFPVFLE 1412 Score = 208 bits (529), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 155/497 (31%), Positives = 235/497 (47%), Gaps = 53/497 (10%) Query: 3220 QAAIAAQQLPAAPAPLLQPGQRGAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALMLEG 3279 Q A ++Q +P P + LS AQ RLW + +++ ++YN++ + L G Sbjct: 33 QKANSSQTIP--------PRNNNTELPLSLAQERLWFLHQIN--PSDSSYNIAISWQLAG 82 Query: 3280 VVDAVLLEQALRLLVARHDILRTGFGEDGDGNPVATLH-PFDFSLEQHDLAALPPPQRDL 3338 ++ L +L+ ++ RH+ LRT F +G P + D L DL LPP Q+ Sbjct: 83 KLEISTLLASLQTIIQRHESLRTAFLSQ-EGKPYQKIAANIDLQLPIIDLQGLPPQQQAQ 141 Query: 3339 QLDRLRRSHAAARFALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAA 3398 L + A+ F L Q PL+R L+RLAP Q LLL +HHI+ADGWS +++ E+A Sbjct: 142 TAQDLAKLEASQPFDLTQAPLMRVKLIRLAPNQATLLLTLHHIIADGWSRGILLRELATC 201 Query: 3399 YSALQEGRPYAPPPLPLQYADYAAWQVAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRP 3458 Y A + P L QYAD+A WQ + +A+W+ LA +P T LP+ P Sbjct: 202 YRAFINDEQPSLPALSNQYADFALWQRECLQREEMAAQLAYWQQKLAKLP-TLELPTDYP 260 Query: 3459 CPARATHAGQRLRMHLPAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGT 3518 A G+ LP L ++ L++++GVT + +LLA+F LLH+ + V+G Sbjct: 261 RTALQKFNGKTESYLLPKTLSESLKQLSKQQGVTLFMLLLAAFKVLLHRYCQQDEIVLGV 320 Query: 3519 DVAGRSHPDLERLVGFFVNVLPLRLRPQALAPRASFAAWLRHCADVAVNAFDHQEPGFDR 3578 A R ++ L+GFFVN L LR L+ +F L A AF++QE F + Sbjct: 321 PSANRDRQQIQSLIGFFVNTLVLR---TDLSENPTFTTLLERIRTTAAEAFEYQEIPFAK 377 Query: 3579 IVEAAGVPRERRWNPLVQVLF-------VLQNTPRAALALPGVRAELLEPLENW-----S 3626 +VEA + R+ NPLVQV+F LQN + L +P LE + W + Sbjct: 378 VVEALQIERDLSHNPLVQVMFQVQNEAYQLQNDSQLDLQIPD-----LEIQQTWVETGAT 432 Query: 3627 KFDLALFVEDHAEAGDAEDGPGWRADWVYADALFDAATVAALGRDWQRLLEQVLASPWTP 3686 KFDL + E G Y LF T+ + + + +L Sbjct: 433 KFDLTCHI--------VERSQGLLVVMEYCTDLFQQQTITRMIQHLRVIL---------- 474 Query: 3687 LDAALPSSPSDTKAEVP 3703 AA+ +PS +E+P Sbjct: 475 --AAIVENPSRKISEIP 489 Score = 92.4 bits (228), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 133/521 (25%), Positives = 212/521 (40%), Gaps = 70/521 (13%) Query: 402 GAVGEIEVCGPSVTQGYWQRPQQSAAAFVERDG---------RRWLRTGDLG-FLRDGQL 451 G GE+ + G V +GY RP+ +A F+ + + GD +L DG + Sbjct: 852 GVPGELYIGGAGVARGYLNRPELTAERFISQQSTVNSQQSTVNTLYKPGDRARYLSDGTI 911 Query: 452 YIAGRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAEISRG 511 GR D + +RG V +IE A+ +V++ V V+ + + A + Sbjct: 912 EYLGRLDDQVKIRGFRVELGEIE-AILKAHPSVQEAVVILQKVHPQSSQ---LVAYLVGN 967 Query: 512 MQKLAAPGVIASAIAEAVAQSSLEAPQVVILLNPGGLPKTSSGKLQRSACRSGWRNGELD 571 Q + +A+ + + P + L LP T++GK+ + +L Sbjct: 968 QQTVDFRQYLATKLPAYML------PSAFVWLE--QLPLTTNGKVDKQ---------QLP 1010 Query: 572 AWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQADFFRSGGS 631 A A E E A P+ IE L IW L +V G +FF GG Sbjct: 1011 APAAKPESEQVA--------------PRNAIEATLVEIWTEILGVSV-GIHDNFFERGGD 1055 Query: 632 SLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPLPACVDGQSE- 690 S+ ++Q+VA + ++ TP LF T+A L T + AP G + Sbjct: 1056 SILSIQMVAK-ANNAGIKLTPKQLFQHQTIAE--------LATVIEIAPTTQVEQGIATG 1106 Query: 691 -FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLF- 748 PLT Q WL Q +N A +L++ +L+V+ L+ A+ +L H LR+ F Sbjct: 1107 IVPLTPIQH--WLFEQNLHKWDYFNQAVLLEVAADLEVDYLKQAIEELVLHHDVLRSCFI 1164 Query: 749 -PLRDGTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLR 807 DG Q ++ E + DL A+++ Q S + A + L + Sbjct: 1165 NSSLDGAWEQDIIPTFENGEIFTVVDLNGFSANQQTQQIESVASQLQA-SLDLAQGILFK 1223 Query: 808 AMLVQL-EAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDY 866 L +L + + RL IHH+ DG S I+L++L AY+ A + L L+ + Sbjct: 1224 VALFKLGDNQNHRLLFIIHHLVVDGISWRILLEDLVTAYQQ--LKAKQTSIKLSLKTTSF 1281 Query: 867 AVW-QRQRSQPGSPEFQRQLDYWRARLEGAPALLP-LPTDR 905 W Q + S + Q W LE P LP LP D+ Sbjct: 1282 REWAQNLVNYAESDQVVAQFKTW---LEILPKQLPQLPLDK 1319 >all2643 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1102 Score = 761 bits (1966), Expect = 0.0, Method: Composition-based stats. Identities = 449/1086 (41%), Positives = 629/1086 (57%), Gaps = 62/1086 (5%) Query: 2179 IEALEARAASDAAYALSPMQAGMFFHSSMNAGDGAYINQLRLDLAG-VDEVRLEAVWRDA 2237 ++ ++ R + Y LSPMQ GM FH+ + G Y+ Q+ L L G +D L+ W Sbjct: 1 MQPVDKRKNIENIYPLSPMQQGMLFHTLLTPQAGVYVPQVCLYLEGKLDINALKTAWNQV 60 Query: 2238 VRRHPILRTGFR-QQGDAPEQWVAQPV-LHWRALDLSG-QPPQQQAQLEQIAAAELARGF 2294 V HP LRT F +Q D P Q V + V + W+ LD +QQ +LE ++ F Sbjct: 61 VINHPALRTAFYWEQRDKPFQVVFRQVEIPWKILDWQTISDAEQQVELEIFLESDRTFSF 120 Query: 2295 DLAQPGLMRLVLAKLGEGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAGEEIAAP-TLAY 2353 D+ QP L+RL L +L ++ LIWT+HHL+LDGWSSA + E+ + Y P + Y Sbjct: 121 DIKQPPLLRLTLIQLSATKYILIWTQHHLILDGWSSALVIKEVFQNYYNSPSYYPNSRPY 180 Query: 2354 RHYIDWLQARDGAAARDFWRAQLQHLEEPTLLAGALPRPREDASGHAEHLAAISPAQWQA 2413 YI WLQ +D AA+ FW+ QL PT++ R ++ + E +++P Q Sbjct: 181 GDYIAWLQQQDKIAAKTFWQKQLAGFTTPTVIQRFAQRENKNLTPQ-EQTRSLTPNQTTG 239 Query: 2414 LCQAAKAMRITPGTLLQGAWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTL 2473 L Q AK ++T TLLQGA+AL+L R C + V FG T + RPA L G+ES +GLFINTL Sbjct: 240 LQQWAKEQQLTLNTLLQGAFALLLSRYCNTTDVVFGATSSGRPATLAGVESMVGLFINTL 299 Query: 2474 PLAVRLHAPQDCSDWLRALLHQNLAMREFAHAPLYEIQRWSG-RAGQALFDSILVLENYP 2532 P+ V++ D +WL+ L Q E+ + L EIQ WS G +LFDSILV ENYP Sbjct: 300 PVRVQVSPTDDLVEWLQKLQAQQAEALEYEYTSLLEIQEWSELTPGTSLFDSILVFENYP 359 Query: 2533 MDEA-IDRAADYGLHLSGLRLHEQTSYPLTVVATAQDGLSLRLGYDRSRFGAHQVAQLAD 2591 +D + I + D L + ++ E TS+PLT++ + + LSL++ YDR+RF + + QL + Sbjct: 360 VDTSGISQNQD--LRIIDIQSLEWTSFPLTMLVSVGNQLSLKVKYDRNRFTDNAITQLLE 417 Query: 2592 WLAQALVTLTTAGARLGDCALGSATQRQQALDWSLNGQRFDGQEPVHRLFEQQASRRPDA 2651 L+ ++ G +G+ L + + + W+ + + E +H+ F+ Q R PD Sbjct: 418 HFCNLLLGMSQPGQTIGNLPLLTQQEYETIHKWN-QTEAYYPLECIHQQFDIQVERTPDD 476 Query: 2652 IALQADGAHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAA 2711 +A+ + TY +LN AN LA LQ GV P+T V + ERS MV +L +LKAG Sbjct: 477 VAVVFEEQQLTYRELNQRANQLAHYLQTWGVQPETPVGIYIERSLEMVIGILGILKAGGC 536 Query: 2712 YLPLDPDYPAERLAWMLEDARPACLLSHRGLHHRL-----------ALPDTLLLELE-DQ 2759 Y+PLDP YPA RL +++ + + +L+ L +L L TL L L+ D Sbjct: 537 YVPLDPAYPASRLTYIINETQVPVVLTQESLLEKLLGFTSSQASSKVLNKTLCLCLDTDW 596 Query: 2760 LPGSQRGDDPQHNPQPPLHGEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYALQ 2819 +Q+ P +NP ++ E Y+IYTSGSTG PKG N+HR + NRL WMQQ Y L+ Sbjct: 597 QEITQK---PDNNPITNVNHEDAIYIIYTSGSTGTPKGVINTHRGVSNRLYWMQQQYGLE 653 Query: 2820 EGDAVLQKTPFGFDVSVWEFLWPLMTGARLVMAPPGAHRDPAELAALIREQGVSTLHFVP 2879 G+ VLQKTPF FDVSVWEF W L+ G RLVM+ PG H+DP L +I + ++TLHFVP Sbjct: 654 RGEVVLQKTPFSFDVSVWEFFWTLLNGGRLVMSKPGGHQDPNYLLEIIAQHKITTLHFVP 713 Query: 2880 SMLQAFL-ASGQAAACTSLRQVICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDVT 2938 +ML FL A C SL++VICSGEAL E +++FF L A LHNLYGPTEAAIDVT Sbjct: 714 TMLGVFLEAPNLNERCHSLKRVICSGEALSIEIQNRFFQHL-DAELHNLYGPTEAAIDVT 772 Query: 2939 HWTCQHGDR-GPVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLT 2997 +W CQ D VPIG+PI+ + +L+ L +P G+ GE+Y+GG+G+ARGY RP LT Sbjct: 773 YWQCQPTDNLHTVPIGRPITNTQIYLLNDYLQPVPLGIPGEIYIGGVGVARGYWKRPDLT 832 Query: 2998 AERFVAS------PFGQGER------------------LYRTGDLVRWREDGQIDYLGRL 3033 ERFV G GE+ LY+TGDL R+ DG ++YLGRL Sbjct: 833 TERFVGGLGTGDWGLGTGEKNNPTLNSQLSTQHSALSTLYKTGDLARYLPDGNLEYLGRL 892 Query: 3034 DHQVKIRGLRIELGEIEAQLLALDEVEEAVVVAHEHGA-GPVLAGYVASRRWQRQD---A 3089 D+QVKIRGLRIELGEIEA + +V++AVV+ A L YV + + Sbjct: 893 DNQVKIRGLRIELGEIEAVINQHPDVQQAVVILDSKQADNQRLGAYVVQKSTSLESPDFT 952 Query: 3090 ATLKQALAARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAPR-LHSEDFAYAAPQGQVE 3148 + L++ LA++LP+YM+P+V +L LPL NGKI+R+ALP P + + +Y AP+ E Sbjct: 953 SELEKLLASQLPEYMLPSVFVMLSELPLLPNGKINRQALPTPETVRHANQSYIAPRNSTE 1012 Query: 3149 QRLAQIWQALLGLERVGRFDHFFELGGHSLLAASLVARLRYQGEAGVGVALPLRLVFAYP 3208 +A I +L LER+G ++FFELGG+SL A + +RLR + LPL VF P Sbjct: 1013 TIIANILADVLRLERMGVDENFFELGGNSLSAIRVTSRLR----EAFQLDLPLHSVFEKP 1068 Query: 3209 RLHEMA 3214 + +A Sbjct: 1069 TIAGLA 1074 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 307/1102 (27%), Positives = 491/1102 (44%), Gaps = 101/1102 (9%) Query: 691 FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLF-- 748 +PL+ QQG+ L P + Y L L G+L + AL+ A + H ALRT F Sbjct: 14 YPLSPMQQGMLFHTLLTPQAGVYVPQVCLYLEGKLDINALKTAWNQVVINHPALRTAFYW 73 Query: 749 PLRDGTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETP--L 806 RD P Q V E P + L Q Q + + F D + P L Sbjct: 74 EQRD-KPFQVVFRQVEI-PWKI---LDWQTISDAEQQVELEIFLESDRTFSFDIKQPPLL 128 Query: 807 RAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDY 866 R L+QL A + L HH+ DGWS +++ E+ Y +PS+ GDY Sbjct: 129 RLTLIQLSATKYILIWTQHHLILDGWSSALVIKEVFQNYYN-----SPSYYPNSRPYGDY 183 Query: 867 AVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWR-LSAA 925 W +Q+ + + F W+ +L G P R Q Q + R L+ Sbjct: 184 IAWLQQQDKIAAKTF------WQKQLAGFTT--PTVIQRFAQRENKNLTPQEQTRSLTPN 235 Query: 926 LSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRR--QTQALVAYL 983 +T L++ A Q +TL + F L L R +D+ GA + R +++V Sbjct: 236 QTTGLQQWAKEQQLTLNTLLQGAFALLLSRYCNTTDVVFGATSSGRPATLAGVESMVGLF 295 Query: 984 INVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVK 1043 IN VR ++ D + ++++Q Q+A+A + L E G + + Sbjct: 296 INTLPVRVQVSPTDDLVEWLQKLQ--AQQAEALEYEYTSLLEIQEWSELTPGTSLFDSIL 353 Query: 1044 CTQQQAIATVRRMGGLDMRV-ELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETV 1102 + + T D+R+ ++Q+ + F L++ + ++ + + + Y F + Sbjct: 354 VFENYPVDTSGISQNQDLRIIDIQSLEWTSFPLTMLVSVGNQ-LSLKVKYDRNRFTDNAI 412 Query: 1103 AG----FAGLLQALAQQVVAAPALALADLQAFPPISAADQV--LQPAEDVAACWRRQALA 1156 F LL ++Q L L Q + I +Q P E + + Q Sbjct: 413 TQLLEHFCNLLLGMSQPGQTIGNLPLLTQQEYETIHKWNQTEAYYPLECIHQQFDIQVER 472 Query: 1157 QPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLAVLD 1216 PD VA+ Q ++ +L QR + LA L G PE+ V +Y R ++ V G+L +L Sbjct: 473 TPDDVAVVFEEQQLTYRELNQRANQLAHYLQTWGVQPETPVGIYIERSLEMVIGILGILK 532 Query: 1217 TGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWL----AQAGVPLLS------- 1265 G YVPLDP PA RL + + ++ VL + L +QA +L+ Sbjct: 533 AGGCYVPLDPAYPASRLTYIINETQVPVVLTQESLLEKLLGFTSSQASSKVLNKTLCLCL 592 Query: 1266 ----LEAAGTAPASPWTPFPVHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKL 1321 E +P T V+ A Y+IYTSGSTG PKGV+ T G++N + + ++ Sbjct: 593 DTDWQEITQKPDNNPIT--NVNHEDAIYIIYTSGSTGTPKGVINTHRGVSNRLYWMQQQY 650 Query: 1322 ALPAAARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVL 1381 L + + + D+ + L +G +L + DP+ + +H + L Sbjct: 651 GLERGEVVLQK-TPFSFDVSVWEFFWTLLNGGRLVMSKPGGHQDPNYLLEIIAQHKITTL 709 Query: 1382 KIVPSHLQALLHAAR-PEQVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSETT 1440 VP+ L L A E+ ++ GEA + R A + N YGP+E Sbjct: 710 HFVPTMLGVFLEAPNLNERCHSLKRVICSGEALSIEIQNRFFQHLDA-ELHNLYGPTEAA 768 Query: 1441 VGVLAQEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHG 1500 + V + V P+G + Q ++L+ L+ P+G GE+Y+GG G+ARGY Sbjct: 769 IDVTYWQCQPTDNLHTV-PIGRPITNTQIYLLNDYLQPVPLGIPGEIYIGGVGVARGYWK 827 Query: 1501 RAALTAERFVA---------------HPFASGQ---------RLYRSGDRARYLGDGSIE 1536 R LT ERFV +P + Q LY++GD ARYL DG++E Sbjct: 828 RPDLTTERFVGGLGTGDWGLGTGEKNNPTLNSQLSTQHSALSTLYKTGDLARYLPDGNLE 887 Query: 1537 FLGRIDDQVKIRGHRVEPGEVRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGA 1596 +LGR+D+QVKIRG R+E GE+ + + V A V+ D QRL ++V + + Sbjct: 888 YLGRLDNQVKIRGLRIELGEIEAVINQHPDVQQAVVILDSKQADNQRLG--AYVVQKSTS 945 Query: 1597 VADP---AGWRATLAADLPDYMLPTL-TPVPALPLTANGKLDRQALAGLMAGAMAAPQQQ 1652 + P + LA+ LP+YMLP++ + LPL NGK++RQAL P+ Sbjct: 946 LESPDFTSELEKLLASQLPEYMLPSVFVMLSELPLLPNGKINRQAL--------PTPE-- 995 Query: 1653 VPQVLQAQQAHQAGAPQGELEHKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARA 1712 V A Q++ AP+ E +A I A+VL+L ++G D+NFFELGG+S+ +++ +R Sbjct: 996 --TVRHANQSYI--APRNSTETIIANILADVLRLERMGVDENFFELGGNSLSAIRVTSRL 1051 Query: 1713 RKE-GLRIAPKAMMEKQTVAAI 1733 R+ L + ++ EK T+A + Sbjct: 1052 REAFQLDLPLHSVFEKPTIAGL 1073 Score = 109 bits (273), Expect = 1e-22, Method: Composition-based stats. Identities = 101/397 (25%), Positives = 168/397 (42%), Gaps = 31/397 (7%) Query: 3247 LSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGE 3306 LSP Q + L+ +A Y L LEG +D L+ A +V H LRT F Sbjct: 16 LSPMQQGMLFHTLLTPQA--GVYVPQVCLYLEGKLDINALKTAWNQVVINHPALRTAFYW 73 Query: 3307 DGDGNPV-ATLHPFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAARFALRQPPLLRAALV 3365 + P + + D + ++ ++L+ S F ++QPPLLR L+ Sbjct: 74 EQRDKPFQVVFRQVEIPWKILDWQTISDAEQQVELEIFLESDRTFSFDIKQPPLLRLTLI 133 Query: 3366 RLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQYADYAAWQV 3425 +L+ + +L+ HH++ DGWS AL+++E+ Y P + P Y DY AW Sbjct: 134 QLSATKYILIWTQHHLILDGWSSALVIKEVFQNYYNSPSYYPNSRP-----YGDYIAWL- 187 Query: 3426 AGAGSRMLEDSIA---WWRDTLAGVPATPYLPSTRPCPARATHAGQRLRMHLPAHLRSGV 3482 +D IA +W+ LAG TP + Q L + +G+ Sbjct: 188 ------QQQDKIAAKTFWQKQLAGF-TTPTVIQRFAQRENKNLTPQEQTRSLTPNQTTGL 240 Query: 3483 QALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGR--SHPDLERLVGFFVNVLP 3540 Q A+ + +T +L +FA LL + D V G +GR + +E +VG F+N LP Sbjct: 241 QQWAKEQQLTLNTLLQGAFALLLSRYCNTTDVVFGATSSGRPATLAGVESMVGLFINTLP 300 Query: 3541 LRLRPQALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQVLFV 3600 +R++ ++P WL+ A +++ I E + + L + V Sbjct: 301 VRVQ---VSPTDDLVEWLQKLQAQQAEALEYEYTSLLEIQEWSELTPG---TSLFDSILV 354 Query: 3601 LQNTPRAALALP---GVRAELLEPLENWSKFDLALFV 3634 +N P + +R ++ LE W+ F L + V Sbjct: 355 FENYPVDTSGISQNQDLRIIDIQSLE-WTSFPLTMLV 390 >PA2402_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1039 Score = 739 bits (1909), Expect = 0.0, Method: Compositional matrix adjust. Identities = 484/1054 (45%), Positives = 616/1054 (58%), Gaps = 40/1054 (3%) Query: 2192 YALSPMQAGMFFHSSMNAGDGAYINQLRLDLAGVDEVRLEAVWRDAVRRHPILRTGFRQQ 2251 Y LSPMQ GM FHS ++ +G Y+NQLR+D+ G+D R A W+ + H ILR+GF + Sbjct: 12 YPLSPMQQGMLFHS-LHGTEGDYVNQLRMDIGGLDPDRFRAAWQATLDAHEILRSGFLWK 70 Query: 2252 GDAPEQWVAQPVLHWRALDLSGQPPQQQAQLEQIAAAELARGFDLAQPGLMRLVLAKLGE 2311 P+ Q V L+L PP Q + A AE GFD A+ L RLVL L Sbjct: 71 DGWPQPL--QVVFEQATLELRLAPPGSDPQRQ--AEAEREAGFDPARAPLQRLVLVPLAN 126 Query: 2312 GRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAGEEIAAPTLAYRHYIDWLQARDGAAARDF 2371 GR HLI+T HH+L+DGWS+AQL AE+++ YAG+E+AA YR YI WLQ+RD A F Sbjct: 127 GRMHLIYTYHHILMDGWSNAQLLAEVLQRYAGQEVAATVGRYRDYIGWLQSRDAKATESF 186 Query: 2372 WRAQLQHLEEPTLLAGALPRPREDASGHAEHLAAISPAQWQALCQAAKAMRITPGTLLQG 2431 WR +L LE PT LA + R + G EHL + P + L A+ ++T TL+Q Sbjct: 187 WRDRLASLEMPTRLAR---QARTEQPGQGEHLRELDPQTTRQLASFAQGQKVTLNTLVQA 243 Query: 2432 AWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTLPLAVRLHAPQDCSDWLRA 2491 AWAL+LQR CGQ VAFG TVA RPAEL GIE+ +GLFINTLP+ Q +D+L+ Sbjct: 244 AWALLLQRHCGQETVAFGATVAGRPAELPGIEAQIGLFINTLPVIAAPQPQQSVADYLQG 303 Query: 2492 LLHQNLAMREFAHAPLYEIQRWSGRAGQALFDSILVLENYPMDEAIDRAADYGLHLSGLR 2551 + NLA+RE H PLY+IQRW+G G+ALFDSILV EN+P+ EA+ R A L S Sbjct: 304 MQALNLALREHEHTPLYDIQRWAGHGGEALFDSILVFENFPVAEAL-RQAPADLEFSTPS 362 Query: 2552 LHEQTSYPLTVVATAQDGLSLRLGYDRSRFGAHQVAQLADWLAQALVTLT-TAGARLGDC 2610 HEQT+YPLT+ T + LSL+ Y R F A +A+L L L + T A LG+ Sbjct: 363 NHEQTNYPLTLGVTLGERLSLQYVYARRDFDAADIAELDRHLLHLLQRMAETPQAALGEL 422 Query: 2611 ALGSATQRQQAL-DWSLNGQRFDGQEPVHRLFEQQASRRPDAIALQADGAHWTYGQLNAA 2669 AL A +RQ+AL DW + + V F QA+ P+AIAL + +Y +L+ Sbjct: 423 ALLDAGERQEALRDWQAPLEALP-RGGVAAAFAHQAASAPEAIALVCGDEYLSYAELDMR 481 Query: 2670 ANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAAYLPLDPDYPAERLAWMLE 2729 A LAR L+A GV + +VA+ AERS +V LL +LKAGA YLPLDP+YPAERLA+ML Sbjct: 482 AERLARGLRARGVAAEALVAIAAERSFDLVVGLLGILKAGAGYLPLDPNYPAERLAYMLR 541 Query: 2730 DARPACLLSHRGLHHRLALP-DTLLLELED-QLPGSQRGDDPQHNPQPPLHGEHLAYVIY 2787 D+ L+ L RL P + L LE P S P P + GE LAYVIY Sbjct: 542 DSGARWLICQETLAERLPCPAEVERLPLETAAWPASA-----DTRPLPEVAGETLAYVIY 596 Query: 2788 TSGSTGRPKGAGNSHRALYNRLRWMQQAYALQEGDAVLQKTPFGFDVSVWEFLWPLMTGA 2847 TSGSTG+PKG S AL + + Y + GD LQ FD + + PL+ GA Sbjct: 597 TSGSTGQPKGVAVSQAALVAHCQAAARTYGVGPGDCQLQFASISFDAAAEQLFVPLLAGA 656 Query: 2848 RLVMAPPGAHRDPAELAALIREQGVSTLHFVPSMLQAFLAS-GQAAACTSLRQVICSGEA 2906 R+++ G LA + V+ L P+ LQ A ++R I GEA Sbjct: 657 RVLLGDAG-QWSAQHLADEVERHAVTILDLPPAYLQQQAEELRHAGRRIAVRACILGGEA 715 Query: 2907 LPAEARDQFFALLPQAALH-----NLYGPTEAAIDVTHWTCQHGDRGPVPIGQPISGLRA 2961 A +LL Q A+ N YGPTEA I W C+ + G IG+ + RA Sbjct: 716 WDA-------SLLTQQAVQAEAWFNAYGPTEAVITPLAWHCRTQEGGAPAIGRALGARRA 768 Query: 2962 VVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLTAERFVASPF-GQGERLYRTGDLVR 3020 +LDA L G+ GELY+GG LARGYLGRPG TAERFVA PF G GERLYRTGDL R Sbjct: 769 CILDAALQPCAPGMIGELYIGGQCLARGYLGRPGQTAERFVADPFSGSGERLYRTGDLAR 828 Query: 3021 WREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALDEVEEAVVVAHEHGAGPVLAGYVA 3080 +R DGQ++YLGR D Q+KIRG RIE+GEIE+QLLA V EA VVA + GP+LA Y+ Sbjct: 829 YRVDGQVEYLGRADQQIKIRGFRIEIGEIESQLLAHPYVAEAAVVALDGVGGPLLAAYLV 888 Query: 3081 SRRWQRQD--AATLKQALAARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAPRLHSEDF 3138 R R + A L+ LA RLP YM P +L +LPLNANGK+DRKALP + Sbjct: 889 GRDAMRGEDLLAELRTWLAGRLPAYMQPTAWQVLSSLPLNANGKLDRKALPKVDAAARRQ 948 Query: 3139 AYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHSLLAASLVARLRYQGEAGVGVA 3198 A P+ +E+ +A IW+ALLG+E + R +HFFELGGHSL A +V+RLR E V Sbjct: 949 AGEPPREGLERSVAAIWEALLGVEGIARDEHFFELGGHSLSATRVVSRLRQDLELDV--- 1005 Query: 3199 LPLRLVFAYPRLHEMAACIEGQAAIAAQQLPAAP 3232 PLR++F P L + AA +E QAA AA L P Sbjct: 1006 -PLRILFERPVLADFAASLESQAASAAPVLQILP 1038 Score = 350 bits (899), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 368/1096 (33%), Positives = 515/1096 (46%), Gaps = 100/1096 (9%) Query: 691 FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPL 750 +PL+ QQG+ L L Y +D+ G L + A H LR+ F Sbjct: 12 YPLSPMQQGM-LFHSLHGTEGDYVNQLRMDIGG-LDPDRFRAAWQATLDAHEILRSGFLW 69 Query: 751 RDGTPVQQVLDIDEARPMLLRSDLRRQP--ADKRAQAAASALQRFHAQAFRLDSETPL-R 807 +DG P Q L + + L +LR P +D + QA A F + PL R Sbjct: 70 KDGWP--QPLQVVFEQATL---ELRLAPPGSDPQRQAEAEREAGFDP------ARAPLQR 118 Query: 808 AMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYA 867 +LV L L HHI DGWS +L E+ Y + A + DY Sbjct: 119 LVLVPLANGRMHLIYTYHHILMDGWSNAQLLAEVLQRYAGQEVAATVG------RYRDYI 172 Query: 868 VWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHG-GEGQHRWRLSAAL 926 W + R + F WR RL A L +PT RQA G+G+H L Sbjct: 173 GWLQSRDAKATESF------WRDRL----ASLEMPTRLARQARTEQPGQGEHLRELDPQT 222 Query: 927 STALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRR--QTQALVAYLI 984 + L A Q VTL V A + L LQR GQ + GA A R +A + I Sbjct: 223 TRQLASFAQGQKVTLNTLVQAAWALLLQRHCGQETVAFGATVAGRPAELPGIEAQIGLFI 282 Query: 985 N-VQVVRTRIDERS--DFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLF- 1040 N + V+ ++S D+L M+ + A++E H+ PL +Q G LF Sbjct: 283 NTLPVIAAPQPQQSVADYLQGMQALNLALRE---HEHTPL----YDIQRWAGHGGEALFD 335 Query: 1041 QVKCTQQQAIATVRRMGGLDMRVELQANAE-SHFDLSLDFTDADEGIDILLAYAPALFDA 1099 + + +A R D+ +N E +++ L+L T E + + YA FDA Sbjct: 336 SILVFENFPVAEALRQAPADLEFSTPSNHEQTNYPLTLGVT-LGERLSLQYVYARRDFDA 394 Query: 1100 ETVAGFAGLLQALAQQVVAAPALALADL---------QAFPPISAADQVLQPAEDVAACW 1150 +A L L Q++ P AL +L +A A + L P VAA + Sbjct: 395 ADIAELDRHLLHLLQRMAETPQAALGELALLDAGERQEALRDWQAPLEAL-PRGGVAAAF 453 Query: 1151 RRQALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCG 1210 QA + P+A+AL CG +++S +L R + LA+ L A G E+ VA+ A R D V G Sbjct: 454 AHQAASAPEAIALVCGDEYLSYAELDMRAERLARGLRARGVAAEALVAIAAERSFDLVVG 513 Query: 1211 MLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAG 1270 +L +L GA Y+PLDP PAERLA+ L+DSGARW++ + A A V L LE A Sbjct: 514 LLGILKAGAGYLPLDPNYPAERLAYMLRDSGARWLICQETLAERLPCPAEVERLPLETAA 573 Query: 1271 TAPASPWTPFP-VHPAQAAYLIYTSGSTGRPKGVLVTRGGLANYVAAVLEKLALPAAARS 1329 ++ P P V AY+IYTSGSTG+PKGV V++ L + A + Sbjct: 574 WPASADTRPLPEVAGETLAYVIYTSGSTGQPKGVAVSQAALVAHCQAAARTYGV-GPGDC 632 Query: 1330 MAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQ 1389 ++++ D L+ L +G ++ L+ + A + HAV +L + P++LQ Sbjct: 633 QLQFASISFDAAAEQLFVPLLAGARV-LLGDAGQWSAQHLADEVERHAVTILDLPPAYLQ 691 Query: 1390 ----ALLHAARPEQVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSETTVGVLA 1445 L HA R V +LGGEA LL + A A N YGP+E + LA Sbjct: 692 QQAEELRHAGRRIAV---RACILGGEAWDASLLTQQAVQAEAW--FNAYGPTEAVITPLA 746 Query: 1446 QEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALT 1505 + A +G AL +A +LD L+ G +GELY+GG LARGY GR T Sbjct: 747 WHCRTQEGGAPA--IGRALGARRACILDAALQPCAPGMIGELYIGGQCLARGYLGRPGQT 804 Query: 1506 AERFVAHPFA-SGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRL 1564 AERFVA PF+ SG+RLYR+GD ARY DG +E+LGR D Q+KIRG R+E GE+ QLL Sbjct: 805 AERFVADPFSGSGERLYRTGDLARYRVDGQVEYLGRADQQIKIRGFRIEIGEIESQLLAH 864 Query: 1565 AGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADP--AGWRATLAADLPDYMLPTLTPV 1622 V +AAV+AL D L ++V + A R LA LP YM PT V Sbjct: 865 PYVAEAAVVAL---DGVGGPLLAAYLVGRDAMRGEDLLAELRTWLAGRLPAYMQPTAWQV 921 Query: 1623 -PALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGE-LEHKLAAIW 1680 +LPL ANGKLDR+AL + A A QAG P E LE +AAIW Sbjct: 922 LSSLPLNANGKLDRKALPKVDAAAR----------------RQAGEPPREGLERSVAAIW 965 Query: 1681 AEVLKLPQVGRDDNFFELGGDSILTLKIVARARKE-GLRIAPKAMMEKQTVAAIVAAGAV 1739 +L + + RD++FFELGG S+ ++V+R R++ L + + + E+ +A A+ Sbjct: 966 EALLGVEGIARDEHFFELGGHSLSATRVVSRLRQDLELDVPLRILFERPVLADFAASLES 1025 Query: 1740 QGMLAATPAPAVVAAP 1755 Q AA+ AP + P Sbjct: 1026 Q---AASAAPVLQILP 1038 Score = 91.7 bits (226), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 116/394 (29%), Positives = 167/394 (42%), Gaps = 45/394 (11%) Query: 3297 HDILRTGFGEDGDGNPVATLHPFDFSLEQHDLAA-LPPPQRDLQLDRLRRSHAAARFALR 3355 H+ILR+GF DG P P EQ L L PP D Q R + A F Sbjct: 60 HEILRSGFLWK-DGWP----QPLQVVFEQATLELRLAPPGSDPQ--RQAEAEREAGFDPA 112 Query: 3356 QPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPL 3415 + PL R LV LA + L+ HHI+ DGWS A ++ E+ Y+ + Sbjct: 113 RAPLQRLVLVPLANGRMHLIYTYHHILMDGWSNAQLLAEVLQRYAGQEVAATVG------ 166 Query: 3416 QYADYAAWQVAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQ--RLRMH 3473 +Y DY W SR + + ++WRD LA + +P+ AR GQ LR Sbjct: 167 RYRDYIGW----LQSRDAKATESFWRDRLASLE----MPTRLARQARTEQPGQGEHLREL 218 Query: 3474 LPAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGR--SHPDLERL 3531 P R + + A+ + VT ++ A++A LL + G G VAGR P +E Sbjct: 219 DPQTTRQ-LASFAQGQKVTLNTLVQAAWALLLQRHCGQETVAFGATVAGRPAELPGIEAQ 277 Query: 3532 VGFFVNVLPLRLRPQALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRW 3591 +G F+N LP+ PQ P+ S A +L+ + + +H+ I AG E Sbjct: 278 IGLFINTLPVIAAPQ---PQQSVADYLQGMQALNLALREHEHTPLYDIQRWAGHGGE--- 331 Query: 3592 NPLVQVLFVLQNTPRA-ALALPGVRAELLEPLEN-WSKFDLALFVEDHAEAGDAEDGPGW 3649 L + V +N P A AL E P + + + L L V G Sbjct: 332 -ALFDSILVFENFPVAEALRQAPADLEFSTPSNHEQTNYPLTLGV---------TLGERL 381 Query: 3650 RADWVYADALFDAATVAALGRDWQRLLEQVLASP 3683 +VYA FDAA +A L R LL+++ +P Sbjct: 382 SLQYVYARRDFDAADIAELDRHLLHLLQRMAETP 415 Score = 89.7 bits (221), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 171/647 (26%), Positives = 248/647 (38%), Gaps = 87/647 (13%) Query: 45 VADASGERRFSFAQLDLRARAYAAAFQQR-CPQGARVLLVLENDEHYVQAFLGCLYAGMV 103 +A G+ S+A+LD+RA A + R A V + E V LG L AG Sbjct: 464 IALVCGDEYLSYAELDMRAERLARGLRARGVAAEALVAIAAERSFDLVVGLLGILKAGAG 523 Query: 104 AVPVFPPESVRPQHLKRLAGIAADAQAACVVLPEPLRQTCAQAALFGAAELLAAEQVADA 163 +P+ P +RLA + D+ A ++ E L + A L A A A Sbjct: 524 YLPLDPNYPA-----ERLAYMLRDSGARWLICQETLAERLPCPAEVERLPLETAAWPASA 578 Query: 164 DAVHWREHTPQPQ----DIAFLQYTSGSTSAPKGVMVSHGNLMANEAAISACMRVREDDI 219 D P P+ +A++ YTSGST PKGV VS L+A+ A + V D Sbjct: 579 DT------RPLPEVAGETLAYVIYTSGSTGQPKGVAVSQAALVAHCQAAARTYGVGPGDC 632 Query: 220 FVTWLPLYHDMGLIGGLLQGLVRGLKTVLCSPRYFLERPLRWLELVARHRGTVSGGPDFA 279 + + + D L L+ G + +L + + L + V RH T+ P Sbjct: 633 QLQFASISFDAA-AEQLFVPLLAGARVLLGDAGQWSAQHL--ADEVERHAVTILDLPPAY 689 Query: 280 YRLCVERIKPAQLQGVDLSSWRVAFCGAEPLRADTFPAFIERFCAAGFSADAAYPCYGLA 339 + E ++ A + + R G E A A+A + YG Sbjct: 690 LQQQAEELRHAGRR----IAVRACILGGEAWDASLL-------TQQAVQAEAWFNAYGPT 738 Query: 340 EATLIVSGGPPHGAHATAFHTAELAAGRAVEGGPDDTRLVACGDIAPHHEVRIIEDGRVQ 399 EA + P H A GRA+ A AP Sbjct: 739 EAVIT-----PLAWHCRTQEGGAPAIGRALGARRACILDAALQPCAP------------- 780 Query: 400 QDGAVGEIEVCGPSVTQGYWQRPQQSAAAFV----ERDGRRWLRTGDLGFLR-DGQLYIA 454 G +GE+ + G + +GY RP Q+A FV G R RTGDL R DGQ+ Sbjct: 781 --GMIGELYIGGQCLARGYLGRPGQTAERFVADPFSGSGERLYRTGDLARYRVDGQVEYL 838 Query: 455 GRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAEISRGMQK 514 GR I +RG + +IE + VA V V + RG Sbjct: 839 GRADQQIKIRGFRIEIGEIESQLLAHPYVAEAAVVALDGVGGPLLAAYLVGRDAMRGEDL 898 Query: 515 LAAPGVIASAIAEAVAQSSLEAPQVVILLNPGGLPKTSSGKLQRSACRSGWRNGELDAWA 574 LA + A Q + A QV+ LP ++GKL R A ++DA A Sbjct: 899 LAELRTWLAGRLPAYMQPT--AWQVL-----SSLPLNANGKLDRKAL------PKVDAAA 945 Query: 575 IVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQADFFRSGGSSLA 634 + GE PP+ +E ++AAIW++ L R FF GG SL+ Sbjct: 946 RRQAGE----------------PPREGLERSVAAIWEALLGVEGIARDEHFFELGGHSLS 989 Query: 635 AMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPL 681 A +VV+ + +++ +LF P LA A A+L A AAP+ Sbjct: 990 ATRVVSRLRQDLELDVPLRILFERPVLADFA---ASLESQAASAAPV 1033 >PA2402_4 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1074 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/1065 (43%), Positives = 610/1065 (57%), Gaps = 56/1065 (5%) Query: 2192 YALSPMQAGMFFHSSMNAGDGAYINQLRLDLAGVDEVRLEAVWRDAVRRHPILRTGFRQQ 2251 Y LSPMQ GM FHS YINQ+R+D++G+D R A W+ A+ RH ILR+GF Q Sbjct: 13 YPLSPMQQGMLFHSLYEQASSDYINQMRVDVSGLDLPRFRAAWQSALDRHAILRSGFAWQ 72 Query: 2252 GD--APEQWVA-QPVLHWRALDLSGQPPQQQAQLEQIAAAELARGFDLAQPGLMRLVLAK 2308 G+ P Q V Q L + DLS Q + A L +AAAE RGF+L + L+RL+L K Sbjct: 73 GELQQPLQIVYRQRQLPFAEEDLS-QAANRDAALLALAAAERERGFELQRAPLLRLLLVK 131 Query: 2309 LGEGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAG---EEIAAPTLAYRHYIDWLQARDG 2365 EG HHLI+T HH+LLDGWS+AQL +E++ +YAG E++ Y YI WLQ +D Sbjct: 132 TAEGEHHLIYTHHHILLDGWSNAQLLSEVLESYAGRSPEQLRDGR--YSDYIAWLQRQDA 189 Query: 2366 AAARDFWRAQLQHLEEPTLLAGALPRP-REDASGHAEHLAAISPAQWQALCQAAKAMRIT 2424 AA FWR Q+ L+EPT L AL +P A+G EHL + L A+ ++T Sbjct: 190 AATEAFWREQMAALDEPTRLVEALAQPGLTSANGVGEHLREVDATATARLRDFARRHQVT 249 Query: 2425 PGTLLQGAWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTLPLAVRLHAPQD 2484 TL+Q WAL+LQR GQ V FG TV+ RPA+L G+E+ +GLFINTLP+ V L Sbjct: 250 LNTLVQAGWALLLQRYTGQHTVVFGATVSGRPADLPGVENQVGLFINTLPVVVTLAPQMT 309 Query: 2485 CSDWLRALLHQNLAMREFAHAPLYEIQRWSGRAGQALFDSILVLENYPMDEAIDRAADYG 2544 + L+ L QNLA+RE H PL+E+QRW+G G+A+FD++LV ENYP+DE ++R++ G Sbjct: 310 LDELLQGLQRQNLALREQEHTPLFELQRWAGFGGEAVFDNLLVFENYPVDEVLERSSAGG 369 Query: 2545 LHLSGLRLHEQTSYPLTVVATAQDGLSLRLGYDRSRFGAHQVAQLADWLAQALVTLTTAG 2604 + + +HEQT+YPL + D LSL+ YDR F A + + L + L TL A Sbjct: 370 VRFGAVAMHEQTNYPLALALGGGDSLSLQFSYDRGLFPAATIER----LGRHLTTLLEAF 425 Query: 2605 A-----RLGDC-ALGSATQRQQALDWSLNGQRFDGQEPVHRLFEQQASRRPDAIALQADG 2658 A RL D L A W+ + + VH+ ++A PDA+A+ D Sbjct: 426 AEHPQRRLVDLQMLEKAELSAIGAIWNRSDSGYPATPLVHQRVAERARMAPDAVAVIFDE 485 Query: 2659 AHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAAYLPLDPD 2718 TY +L++ AN LA L A GVGP+ VA+ +RSA ++ A LAVLKAG AY+PLD + Sbjct: 486 EKLTYAELDSRANRLAHALIARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIE 545 Query: 2719 YPAERLAWMLEDARPACLLSHRGLHHRLALPD---TLLLELEDQLPGSQRGDDPQHNPQP 2775 YP ERL +M++D+R LL+H L RL +P+ L ++ E++ G P H+P+ Sbjct: 546 YPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSVDREEEWAGF-----PAHDPEV 600 Query: 2776 PLHGEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYALQEGDAVLQKTPFGFDVS 2835 LHG++LAYVIYTSGSTG PKG SH L + + Y + D L F FD S Sbjct: 601 ALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDGS 660 Query: 2836 VWEFLWPLMTGARLVMAPPGAHRD-----PAELAALIREQGVSTLHFVPSMLQAFLASGQ 2890 ++ PL+ GAR+++ RD P A + GV+ F P LQ + Sbjct: 661 HEGWMHPLINGARVLI------RDDSLWLPERTYAEMHRHGVTVGVFPPVYLQQLAEHAE 714 Query: 2891 AAACTSLRQVIC-SGEALPAEARDQFFALLPQAALHNLYGPTEAAIDVTHWTCQHGD--- 2946 +V C G+A+ + D + L L N YGPTE + W + GD Sbjct: 715 RDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVTPLLWKARAGDACG 774 Query: 2947 RGPVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLTAERFVASPF 3006 +PIG + +LD LN+LP GVAGELYLGG G+ARGYL RP LTAERFV PF Sbjct: 775 AAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPF 834 Query: 3007 GQ-GERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALDEVEEAVVV 3065 G G RLYR+GDL R R DG +DYLGR+DHQVKIRG RIELGEIEA+L V EAVVV Sbjct: 835 GAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLREHPSVREAVVV 894 Query: 3066 AHEHGAGPVLAGYVA--------SRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPL 3117 A G L GYV S Q + A LK AL RLP+YMVP+ L L +PL Sbjct: 895 AQPGAVGQQLVGYVVAQAPAVADSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPL 954 Query: 3118 NANGKIDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHS 3177 NGK+DRK LP P Y AP+ +EQ++A IW +L L++VG D+FFELGGHS Sbjct: 955 TPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHS 1014 Query: 3178 LLAASLVARLRYQGEAGVGVALPLRLVFAYPRLHEMAACIEGQAA 3222 LLA + AR++ + VGV LPL +F L A Q + Sbjct: 1015 LLAIQVTARMQSE----VGVELPLAALFQTESLQAYAELAAAQTS 1055 Score = 364 bits (934), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 357/1104 (32%), Positives = 508/1104 (46%), Gaps = 117/1104 (10%) Query: 691 FPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPL 750 +PL+ QQG+ + S+ Y +D+ G L + A RHA LR+ F Sbjct: 13 YPLSPMQQGMLFHSLYEQASSDYINQMRVDVSG-LDLPRFRAAWQSALDRHAILRSGFAW 71 Query: 751 RDGTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLRAML 810 + +QQ L I + L ++ A R A + + F L LR +L Sbjct: 72 QG--ELQQPLQIVYRQRQLPFAEEDLSQAANRDAALLALAAAERERGFELQRAPLLRLLL 129 Query: 811 VQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPG---DYA 867 V+ L HHI DGWS +L E+ +Y AG +P +L+ G DY Sbjct: 130 VKTAEGEHHLIYTHHHILLDGWSNAQLLSEVLESY----AGRSPE----QLRDGRYSDYI 181 Query: 868 VWQRQRSQPGSPEFQRQLDYWRARLEG--APALLPLPTDRPRQAGAHGGEGQHRWRLSAA 925 W +++ + F WR ++ P L +P A+G G+H + A Sbjct: 182 AWLQRQDAAATEAF------WREQMAALDEPTRLVEALAQPGLTSANG-VGEHLREVDAT 234 Query: 926 LSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRR--QTQALVAYL 983 + LR A VTL V A + L LQR +GQ + GA + R + V Sbjct: 235 ATARLRDFARRHQVTLNTLVQAGWALLLQRYTGQHTVVFGATVSGRPADLPGVENQVGLF 294 Query: 984 INVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALV--SALQPERVAGANPLFQ 1041 IN V + + L++ +Q+ + + PL L + E V +F+ Sbjct: 295 INTLPVVVTLAPQMTLDELLQGLQRQNLALREQEHTPLFELQRWAGFGGEAVFDNLLVFE 354 Query: 1042 ---VKCTQQQAIATVRRMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFD 1098 V +++ A R G + M + ++++ L+L D + + +Y LF Sbjct: 355 NYPVDEVLERSSAGGVRFGAVAM------HEQTNYPLALALGGGD-SLSLQFSYDRGLFP 407 Query: 1099 AETVAGFAGLLQALAQQVVAAPALALADLQAFPPISAADQVLQPAE--DVAACWRR---- 1152 A T+ L L + P L DLQ +L+ AE + A W R Sbjct: 408 AATIERLGRHLTTLLEAFAEHPQRRLVDLQ----------MLEKAELSAIGAIWNRSDSG 457 Query: 1153 -------------QALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVAL 1199 +A PDAVA+ + ++ +L R + LA L A G GPE RVA+ Sbjct: 458 YPATPLVHQRVAERARMAPDAVAVIFDEEKLTYAELDSRANRLAHALIARGVGPEVRVAI 517 Query: 1200 YAGRGIDFVCGMLAVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQA 1259 R + + LAVL G AYVPLD + P ERL + +QDS A +L Sbjct: 518 AMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPE 577 Query: 1260 GVPLLSLEAAGTAPASPWTPFPVHPAQAA-------YLIYTSGSTGRPKGVLVTRGGLAN 1312 G+ LS++ W FP H + A Y+IYTSGSTG PKGV V+ G L Sbjct: 578 GLSCLSVDRE-----EEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIA 632 Query: 1313 YVAAVLEKLALPAAARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAY 1372 ++ A E+ + + +S A D H L +G ++ LI D + P+ A Sbjct: 633 HIVATGERYEMTPEDCELHFMS-FAFDGSHEGWMHPLINGARV-LIRDDSLWLPERTYAE 690 Query: 1373 LHEHAVDVLKIVPSHLQALL-HAARPEQVLPRHTLVLGGEAT---GWPLLERIAALQPAC 1428 +H H V V P +LQ L HA R P GG+A + L R AL+P Sbjct: 691 MHRHGVTVGVFPPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWR--ALKPKY 748 Query: 1429 RVLNHYGPSETTVGVLAQEA-ASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGEL 1487 + N YGP+ET V L +A A + AA +P+G+ L ++LD QL PVG GEL Sbjct: 749 -LFNGYGPTETVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGEL 807 Query: 1488 YLGGAGLARGYHGRAALTAERFVAHPF-ASGQRLYRSGDRARYLGDGSIEFLGRIDDQVK 1546 YLGG G+ARGY R ALTAERFV PF A G RLYRSGD R DG +++LGR+D QVK Sbjct: 808 YLGGEGVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVK 867 Query: 1547 IRGHRVEPGEVRQQLLRLAGVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADP------ 1600 IRG R+E GE+ +L V +A V+A P A QL G++V A AVAD Sbjct: 868 IRGFRIELGEIEARLREHPSVREAVVVAQPGAVGQ---QLVGYVVAQAPAVADSPEAQAE 924 Query: 1601 --AGWRATLAADLPDYMLPT-LTPVPALPLTANGKLDRQALAGLMAGAMAAPQQQVPQVL 1657 A + L LP+YM+P+ L + +PLT NGKLDR+ L PQ P Sbjct: 925 CRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGL----------PQ---PDAS 971 Query: 1658 QAQQAHQAGAPQGELEHKLAAIWAEVLKLPQVGRDDNFFELGGDSILTLKIVARARKE-G 1716 QQ + AP+ +LE ++A IWAEVL+L QVG DDNFFELGG S+L +++ AR + E G Sbjct: 972 LLQQVYV--APRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLAIQVTARMQSEVG 1029 Query: 1717 LRIAPKAMMEKQTVAAIVAAGAVQ 1740 + + A+ + +++ A A Q Sbjct: 1030 VELPLAALFQTESLQAYAELAAAQ 1053 Score = 94.4 bits (233), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 170/652 (26%), Positives = 252/652 (38%), Gaps = 104/652 (15%) Query: 45 VADASGERRFSFAQLDLRARAYAAAFQQRC--PQGARVLLVLENDEHYVQAFLGCLYAGM 102 VA E + ++A+LD RA A A R P+ RV + ++ + AFL L AG Sbjct: 479 VAVIFDEEKLTYAELDSRANRLAHALIARGVGPE-VRVAIAMQRSAEIMVAFLAVLKAGG 537 Query: 103 VAVPV---FPPESVRPQHLKRLAGIAADAQAACVVLPEPLRQTCAQAALFGAAELLAAEQ 159 VP+ +P E + A + LP P +C + E+ Sbjct: 538 AYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLS---------VDREE 588 Query: 160 VADADAVHWREHTPQPQDIAFLQYTSGSTSAPKGVMVSHGNLMANEAAISACMRVREDDI 219 H E ++A++ YTSGST PKGV VSHG L+A+ A + +D Sbjct: 589 EWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYEMTPEDC 648 Query: 220 FVTWLPLYHDMGLIGGLLQGLVRGLKTVLCSPRYFLERPLRWLELVARHRGTVSGGPDFA 279 + ++ D G G + L+ G + ++ +L P R + RH TV P Sbjct: 649 ELHFMSFAFD-GSHEGWMHPLINGARVLIRDDSLWL--PERTYAEMHRHGVTVGVFP--- 702 Query: 280 YRLCVERIKPAQLQGVDLSSWRVAFCGAEPLRADTFPAFIERFCAAGFSADA-AYPCYGL 338 P LQ + AE D P + +C F DA A Y L Sbjct: 703 ---------PVYLQQL-----------AEHAERDGNPPPVRVYC---FGGDAVAQASYDL 739 Query: 339 A----EATLIVSGGPPHGAHATAFHTAELAAGRAVEGGPDDTRLVACGDIAPHHEVRIIE 394 A + + +G P T L RA G + G + + I+ Sbjct: 740 AWRALKPKYLFNGYGPTETVVTPL----LWKARA--GDACGAAYMPIGTLLGNRSGYIL- 792 Query: 395 DGRVQ--QDGAVGEIEVCGPSVTQGYWQRPQQSAAAFVERD----GRRWLRTGDLGFLR- 447 DG++ G GE+ + G V +GY +RP +A FV G R R+GDL R Sbjct: 793 DGQLNLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRA 852 Query: 448 DGQLYIAGRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAE 507 DG + GR + +RG + +IE + + +VR+ V A G+ V A+ Sbjct: 853 DGVVDYLGRVDHQVKIRGFRIELGEIEARLREH-PSVREAVVVAQPGAVGQQLVGYVVAQ 911 Query: 508 ISRGMQKLAAPGVIASAIAEAVAQSSLEA------PQVVI---LLNPGGLPKTSSGKLQR 558 AP V S A+A ++ L+ P+ ++ LL +P T +GKL R Sbjct: 912 ---------APAVADSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDR 962 Query: 559 SACRSGWRNGELDAWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAV 618 DA + + P+ D+E +A IW L+ Sbjct: 963 KGLPQ----------------------PDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQ 1000 Query: 619 AGRQADFFRSGGSSLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAA 670 G +FF GG SL A+QV A + VE A LF +L A A AA Sbjct: 1001 VGLDDNFFELGGHSLLAIQVTARMQSEVGVELPLAALFQTESLQAYAELAAA 1052 Score = 84.7 bits (208), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 118/414 (28%), Positives = 178/414 (42%), Gaps = 71/414 (17%) Query: 3296 RHDILRTGFGEDGDGNPVATLHPFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAAR---- 3351 RH ILR+GF G+ P Q L P + DL R + A Sbjct: 61 RHAILRSGFAWQGELQ-----QPLQIVYRQRQL---PFAEEDLSQAANRDAALLALAAAE 112 Query: 3352 ----FALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSA-----L 3402 F L++ PLLR LV+ A + L+ HHI+ DGWS A ++ E+ +Y+ L Sbjct: 113 RERGFELQRAPLLRLLLVKTAEGEHHLIYTHHHILLDGWSNAQLLSEVLESYAGRSPEQL 172 Query: 3403 QEGRPYAPPPLPLQYADYAAW---QVAGAGSRMLEDSIAWWRDTLAGV--PATPYLPSTR 3457 ++GR Y+DY AW Q A A + A+WR+ +A + P + Sbjct: 173 RDGR----------YSDYIAWLQRQDAAA-------TEAFWREQMAALDEPTRLVEALAQ 215 Query: 3458 PCPARATHAGQRLRMHLPAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVG 3517 P A G+ LR + A + ++ ARR VT ++ A +A LL + +G V G Sbjct: 216 PGLTSANGVGEHLR-EVDATATARLRDFARRHQVTLNTLVQAGWALLLQRYTGQHTVVFG 274 Query: 3518 TDVAGR--SHPDLERLVGFFVNVLPLRLRPQALAPRASFAAWLR--HCADVAVNAFDHQE 3573 V+GR P +E VG F+N LP+ + LAP+ + L+ ++A+ +H Sbjct: 275 ATVSGRPADLPGVENQVGLFINTLPVVV---TLAPQMTLDELLQGLQRQNLALREQEHT- 330 Query: 3574 PGFDRIVEAAGVPRERRWNPLVQVLFVLQNTPRAAL----ALPGVRAELLEPLENWSKFD 3629 P F+ + AG E ++ L+ V +N P + + GVR + + + + Sbjct: 331 PLFE-LQRWAGFGGEAVFDNLL----VFENYPVDEVLERSSAGGVRFGAV-AMHEQTNYP 384 Query: 3630 LALFVEDHAEAGDAEDGPGWRADWVYADALFDAATVAALGRDWQRLLEQVLASP 3683 LAL A G G + Y LF AAT+ LGR LLE P Sbjct: 385 LAL-----ALGG----GDSLSLQFSYDRGLFPAATIERLGRHLTTLLEAFAEHP 429 >BS_ppsC_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Bsu Bacillus subtilis Length = 1505 Score = 687 bits (1773), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/1517 (32%), Positives = 743/1517 (48%), Gaps = 123/1517 (8%) Query: 686 DGQSEFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALR 745 + Q +P++ AQ+ +++ QL+ YN+ VL+L G+L +E ++ A +L RH +LR Sbjct: 3 EKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRHESLR 62 Query: 746 TLFPLRD--GTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSE 803 T F +D G PVQ++ D P L++ + A+ A F + F L Sbjct: 63 TAFE-QDAGGDPVQRIHD---EVPFTLQTTVLG------ARTEEEAAAAF-IKPFDLSQA 111 Query: 804 TPLRAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQP 863 RA +V++ L + +HHI +DG S+ I++ E Y R PAL +Q Sbjct: 112 PLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNR------KLPALRIQY 165 Query: 864 GDYAVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLS 923 DYAVWQ + ++ Q YW +LEG +L LP D R + + L Sbjct: 166 KDYAVWQEGFKTGDA--YKTQGAYWLKQLEGELPVLDLPADHARPPMRSFAGDKVSFTLD 223 Query: 924 AALSTALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQALVAYL 983 +++ L KLA G TLY +LA +T L RLSGQ D+ VG+P A R + + ++ Sbjct: 224 QEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMF 283 Query: 984 INVQVVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVK 1043 +N +RTR + F+ +++V++ EA HQD P + LV L+ R NPLF V Sbjct: 284 VNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFDVM 343 Query: 1044 CTQQQAIATVRRMGGLDMR-VELQANAESHFDLSLDFTDADEGI-DILLAYAPALFDAET 1101 Q + L ++ + S FDL+L + G+ + ++ L+ +T Sbjct: 344 FVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRGLLTFQMEFSTDLYKKKT 403 Query: 1102 VAGFAGLLQALAQQVVAAPALALADLQAFPPISAA--------DQVLQP-AEDVAACWRR 1152 + + + ++ AL + A ++ P E ++ + Sbjct: 404 IEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHELNRTKIDYPRNETISRLFEM 463 Query: 1153 QALAQPDAVALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGML 1212 QA P+AVA+ Q + L + +A L G GP+S VAL GR + + GML Sbjct: 464 QAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGVGPDSVVALLTGRTPELIAGML 523 Query: 1213 AVLDTGAAYVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTA 1272 +L G AY+P+D LP ER+A+ L DS A +L ++ L ++ +E Sbjct: 524 GILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSEKTEKRLLGIECEQII-IEDIQKQ 582 Query: 1273 PASPWTPFPVHPAQAAYLIYTSGSTGRPKGVLVTRGGL------ANYVAAVLEKLALPAA 1326 + P AY+IYTSGSTG+PKGV++ + + +NY+ E L Sbjct: 583 GEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQRSVIRLVKNSNYITFTPEDRLL--- 639 Query: 1327 ARSMAMISTVAADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPS 1386 M S++ D+G ++G L +G LHL D Y+ + + + S Sbjct: 640 -----MTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQLKRYIEHQGITTIWLTSS 694 Query: 1387 HLQALLHAARPEQVLPR-HTLVLGGEATGWPLLERIAALQPACRVLNHYGPSETTVGVLA 1445 L + EQ + L++GGEA + RI + P + N YGP+E T Sbjct: 695 LFNHL--TEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPEVSIWNGYGPTENTTFSTC 752 Query: 1446 QEAASASRRAAVLPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALT 1505 + +P+G + A++L++ PVGAVGEL +GG G+ARGY GR LT Sbjct: 753 LHIQKTYELS--IPIGRPVGNSTAFILNQWGVLQPVGAVGELCVGGDGVARGYLGRPDLT 810 Query: 1506 AERFVAHPFASGQRLYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRLA 1565 E+FV HPFA G RLYR+GD AR+L DG+IE++GRIDDQVK+RG+RVE GE+ L ++ Sbjct: 811 KEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQVKVRGYRVELGEIETALRQID 870 Query: 1566 GVVDAAVLALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAADLPDYMLPT-LTPVPA 1624 GV +AAVLA A ++ +L G+I AG A+ R+ LA LP+YM+P + + Sbjct: 871 GVKEAAVLARTAQTGSK--ELFGYISVKAGTNAEQV--RSLLARSLPNYMIPAYIIEMET 926 Query: 1625 LPLTANGKLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGELEHKLAAIWAEVL 1684 LPLT+NGKL+R+AL +A+ Q +P P+ ELE +LA IW EVL Sbjct: 927 LPLTSNGKLNRKALP---EPDVASKQTYIP-------------PRNELEEQLALIWQEVL 970 Query: 1685 KLPQVGRDDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQTVAA----------IV 1734 + ++G +D+FFELGGDSI L++ AR + GL + + + I+ Sbjct: 971 GIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIRKSERII 1030 Query: 1735 AAGAVQGMLAATPAPAVVAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLNAPG-LDAGV 1793 G +QG D+P TPVQ WFF Q H+NQSV+L G L Sbjct: 1031 EQGPIQG---------------DVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENA 1075 Query: 1794 LRRALALLAQRHESLRLRFVQEGGQWRQ-RRG---PALLPLEIID--GDEPG---AIAAA 1844 LR AL LA+ H++LR+ + + +W Q +G L L I D E G I Sbjct: 1076 LRPALKKLAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQE 1135 Query: 1845 GELVQRSLDLAQGPLMAAAWIRLDAQGKQGRLLLAGHHLVVDGVSWRVLLDDLAGLYHTL 1904 +Q+S++L +GPL+ AA + L LA HHLVVDGVSWR+LL+DL+ Y Sbjct: 1136 VADLQQSINLQEGPLLHAALFKTLT---GDYLFLAIHHLVVDGVSWRILLEDLSAGYQQA 1192 Query: 1905 QQGGTPAELPPATDLY-TWSQALRAHAQRPAVTDQLAYWRSV-----VDTPEPPLADATA 1958 G T +LPP TD Y +++ ++ +AQ + + AYWRSV + P Sbjct: 1193 AAGQT-IQLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNI 1251 Query: 1959 NLAGRAADAGFVLDADATARLLALGAHADPAVRVAPQDLLLAVLARVLCEWSGRDSLLFE 2018 + + R + + + +AD TA LL H A QD+LL + +CEW+G L Sbjct: 1252 DFSKRDSLSFSLTEAD-TAVLLQNVNH---AYGTDTQDILLTAASLAICEWTGGSKLRIA 1307 Query: 2019 LEGHGREDIPGGLDVSRATGWFTALYPVRLAPGATSTSIPAALEAVRAQLRAVPANGLGY 2078 +EGHGRE I LD+SR GWFT++YP ++ + +++ V+ L +P G+GY Sbjct: 1308 MEGHGREHILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGY 1367 Query: 2079 GLLRYLSG-QGQELAQGAQPQITFNYLGHFDHRIEPAGWTLADEYAGAQRAADSRRRCLF 2137 G+L+YL+ + + + P+I+FNYLG F+ + + +G +R + Sbjct: 1368 GMLKYLTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQII 1427 Query: 2138 EAIARVQQGRLQWQWTY 2154 E A +L + +Y Sbjct: 1428 EMSAMAADKKLHFNLSY 1444 Score = 529 bits (1363), Expect = e-149, Method: Compositional matrix adjust. Identities = 429/1396 (30%), Positives = 654/1396 (46%), Gaps = 104/1396 (7%) Query: 2186 AASDAAYALSPMQAGMFFHSSMNAGDGAYINQLRLDLAG-VDEVRLEAVWRDAVRRHPIL 2244 A Y +S Q ++ + G Y L+L G ++ R++ +++ ++RH L Sbjct: 2 AEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRHESL 61 Query: 2245 RTGFRQQ-GDAPEQWVAQPVLHWRALDLSGQPPQQQAQLEQIAAAELARGFDLAQPGLMR 2303 RT F Q G P Q + V + Q A+ E+ AAA + FDL+Q L R Sbjct: 62 RTAFEQDAGGDPVQRIHDEV------PFTLQTTVLGARTEEEAAAAFIKPFDLSQAPLFR 115 Query: 2304 LVLAKLGEGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAGEEIAAPTLAYRHYIDWLQA- 2362 + K+ + RH L+ HH++ DG S L E Y ++ A + Y+ Y W + Sbjct: 116 AQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDYAVWQEGF 175 Query: 2363 RDGAAARD---FWRAQLQHLEEPTL-LAGALPRPREDASGHAEHLAAISPAQWQALCQAA 2418 + G A + +W QL+ E P L L RP + + + L + A Sbjct: 176 KTGDAYKTQGAYWLKQLEG-ELPVLDLPADHARPPMRSFAGDKVSFTLDQEVTSGLYKLA 234 Query: 2419 KAMRITPGTLLQGAWALVLQRCCGQSAVAFGVTVADRPAELEGIESTLGLFINTLPLAVR 2478 + T +L A+ L R GQ + G +A RP + +E LG+F+NTL L R Sbjct: 235 RENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHK--DLEPILGMFVNTLALRTR 292 Query: 2479 LHAPQDCSDWLRALLHQNLAMREFAHA--PLYEI----QRWSGRAGQALFDSILVLENYP 2532 + +L+ + + AM F H P E+ + + LFD + VL+N Sbjct: 293 PEGGKPFVQYLQEV--RETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFDVMFVLQN-- 348 Query: 2533 MDEAIDRAADYGLHLSGLRLHEQTSYPLTVVATAQDG--LSLRLGYDRSRFGAHQVAQLA 2590 MD+ + L + H+ + + LT+ A Q L+ ++ + + + + Sbjct: 349 MDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRGLLTFQMEFSTDLYKKKTIEKWL 408 Query: 2591 DWLAQALVTLTTAG-ARLGDCALGSATQRQQALDWSLNGQRFD--GQEPVHRLFEQQASR 2647 + L+++ A LG + + + L LN + D E + RLFE QA + Sbjct: 409 QYFNNMLLSIIKDNKAALGTINILNEDE-AHYLIHELNRTKIDYPRNETISRLFEMQAEQ 467 Query: 2648 RPDAIALQADGAHWTYGQLNAAANALARRLQAAGVGPDTVVALLAERSAAMVTALLAVLK 2707 P+A+A+ +D +TY LN+ AN +A LQ GVGPD+VVALL R+ ++ +L +LK Sbjct: 468 TPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGVGPDSVVALLTGRTPELIAGMLGILK 527 Query: 2708 AGAAYLPLDPDYPAERLAWMLEDARPACLLSHRGLHHRLALPDTLLLELED-QLPGSQRG 2766 AG AYLP+D + P ER+A+ML D+R A LL RL + + +ED Q G + Sbjct: 528 AGGAYLPIDSNLPVERIAYMLSDSRAALLLQSEKTEKRLLGIECEQIIIEDIQKQGEAKN 587 Query: 2767 DDPQHNPQPPLHGEHLAYVIYTSGSTGRPKGAGNSHRALYNRLRWMQQAYALQEGDAVLQ 2826 + P LAY+IYTSGSTG+PKG R++ RL D +L Sbjct: 588 VESSAGPHS------LAYIIYTSGSTGKPKGVMIEQRSVI-RLVKNSNYITFTPEDRLLM 640 Query: 2827 KTPFGFDVSVWEFLWPLMTGARLVMAPPGAHRDPAELAALIREQGVSTLHFVPSMLQAFL 2886 + GFDV +E PL+ GA L ++ D +L I QG++T+ S+ L Sbjct: 641 TSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQLKRYIEHQGITTIWLTSSLFN-HL 699 Query: 2887 ASGQAAACTSLRQVICSGEALPAEARDQFFALLPQAALHNLYGPTEAAIDVTHWTCQHGD 2946 + L+ +I GEAL ++ + P+ ++ N YGPTE + T TC H Sbjct: 700 TEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPEVSIWNGYGPTE---NTTFSTCLHIQ 756 Query: 2947 RG---PVPIGQPISGLRAVVLDADLNVLPCGVAGELYLGGIGLARGYLGRPGLTAERFVA 3003 + +PIG+P+ A +L+ + P G GEL +GG G+ARGYLGRP LT E+FV Sbjct: 757 KTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGELCVGGDGVARGYLGRPDLTKEKFVP 816 Query: 3004 SPFGQGERLYRTGDLVRWREDGQIDYLGRLDHQVKIRGLRIELGEIEAQLLALDEVEEAV 3063 PF G+RLYRTGDL RW DG I+Y+GR+D QVK+RG R+ELGEIE L +D V+EA Sbjct: 817 HPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQVKVRGYRVELGEIETALRQIDGVKEAA 876 Query: 3064 VVAHEHGAGPV-LAGYVASRRWQRQDAATLKQALAARLPDYMVPAVLTLLPTLPLNANGK 3122 V+A G L GY++ + +A ++ LA LP+YM+PA + + TLPL +NGK Sbjct: 877 VLARTAQTGSKELFGYISVKAG--TNAEQVRSLLARSLPNYMIPAYIIEMETLPLTSNGK 934 Query: 3123 IDRKALPAPRLHSEDFAYAAPQGQVEQRLAQIWQALLGLERVGRFDHFFELGGHSLLAAS 3182 ++RKALP P + S+ Y P+ ++E++LA IWQ +LG++R+G D FFELGG S+ A Sbjct: 935 LNRKALPEPDVASKQ-TYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQ 993 Query: 3183 LVARL-RYQGEAGVGVALPLRLVFAYPRLHEMAACIEGQAAIAAQQLPAAPAPLLQPGQR 3241 + ARL RY G++L + +F +P++ +++ I I Q P Sbjct: 994 VSARLGRY------GLSLQVSDLFRHPKIKDLSPFIRKSERIIEQGPIQGDVP------- 1040 Query: 3242 GAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILR 3301 +P Q + D + +N S L G + L AL+ L HD LR Sbjct: 1041 -----WTPVQQWFFSQDI----EERHHFNQSVMLFHSGRLSENALRPALKKLAEHHDALR 1091 Query: 3302 TGFGED-------GDGNPVATLHPFDFS-LEQHDL---AALPPPQRDLQLDRLRRSHAAA 3350 + D G + L+ S L Q + + DLQ Sbjct: 1092 MVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ----------Q 1141 Query: 3351 RFALRQPPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAP 3410 L++ PLL AAL + L LAIHH+V DG S +++E+++A Y G+ Sbjct: 1142 SINLQEGPLLHAALFKTLT-GDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTIQL 1200 Query: 3411 PPLPLQYADYAAWQVAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQ-R 3469 PP Y +YA A S L A+WR A LP P + + Sbjct: 1201 PPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAE--LPYEIPHHVNIDFSKRDS 1258 Query: 3470 LRMHLP-AHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRSHP-- 3526 L L A +Q + G +LL + + + + +G + + GR H Sbjct: 1259 LSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGREHILP 1318 Query: 3527 --DLERLVGFFVNVLP 3540 D+ R VG+F ++ P Sbjct: 1319 ELDISRTVGWFTSMYP 1334 Score = 217 bits (553), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 135/404 (33%), Positives = 212/404 (52%), Gaps = 27/404 (6%) Query: 3238 PGQRGAQALLSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARH 3297 P ++ +S AQ R++++ +L E YNM A L LEG ++ +++A + L+ RH Sbjct: 1 PAEKQETYPVSSAQKRIYVLQQL--EDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRH 58 Query: 3298 DILRTGFGEDGDGNPVATLH-PFDFSLEQHDLAALPPPQRDLQLDRLRRSHAAARFALRQ 3356 + LRT F +D G+PV +H F+L+ L A + + + F L Q Sbjct: 59 ESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGA--------RTEEEAAAAFIKPFDLSQ 110 Query: 3357 PPLLRAALVRLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPLQ 3416 PL RA +V+++ ++ +LL+ +HHI++DG SV +++ E Y+ + P L +Q Sbjct: 111 APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRK------LPALRIQ 164 Query: 3417 YADYAAWQVAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQRLRMHLPA 3476 Y DYA WQ + A+W L G LP+ P + AG ++ L Sbjct: 165 YKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRSFAGDKVSFTLDQ 224 Query: 3477 HLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRSHPDLERLVGFFV 3536 + SG+ LAR G T Y VLLA++ L + SG D +VG+ +AGR H DLE ++G FV Sbjct: 225 EVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV 284 Query: 3537 NVLPLRLRPQALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQ 3596 N L LR RP+ P F +L+ + A+ AF+HQ+ F+ +V+ + R+ NPL Sbjct: 285 NTLALRTRPEGGKP---FVQYLQEVRETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFD 341 Query: 3597 VLFVLQNTPRAALALPGVRAELLEPLEN----WSKFDLALFVED 3636 V+FVLQN + +L L + L+P N SKFDL L+ ++ Sbjct: 342 VMFVLQNMDQESLELDEL---CLKPAANNGHQTSKFDLTLYAQE 382 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 168/590 (28%), Positives = 248/590 (42%), Gaps = 71/590 (12%) Query: 396 GRVQQDGAVGEIEVCGPSVTQGYWQRPQQSAAAFVER---DGRRWLRTGDLG-FLRDGQL 451 G +Q GAVGE+ V G V +GY RP + FV G R RTGDL +L DG + Sbjct: 781 GVLQPVGAVGELCVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTI 840 Query: 452 YIAGRRKDLIIVRGQNVYPQDIERAVEDQVEAVRKGRVAAFAVNTGEGEGIGVAAEISRG 511 GR D + VRG V +IE A+ Q++ V++ V A TG E G + Sbjct: 841 EYVGRIDDQVKVRGYRVELGEIETALR-QIDGVKEAAVLARTAQTGSKELFGYIS----- 894 Query: 512 MQKLAAPGVIASAIAEAVAQS--SLEAPQVVILLNPGGLPKTSSGKLQRSACRSGWRNGE 569 G A + +A+S + P +I + LP TS+GKL R Sbjct: 895 ----VKAGTNAEQVRSLLARSLPNYMIPAYIIEMET--LPLTSNGKLNR----------- 937 Query: 570 LDAWAIVEEGELKAGPSDAQGGELLAEPPQGDIETALAAIWQSALKRAVAGRQADFFRSG 629 KA P + PP+ ++E LA IWQ L G + FF G Sbjct: 938 ------------KALPEPDVASKQTYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELG 985 Query: 630 GSSLAAMQVVAAVVDRWQVEFTPAMLFAAPTLAASAAQIAALLETGAQAAPLPACVDGQS 689 G S+ A+Q V+A + R+ + + LF P + + I E + P+ Q Sbjct: 986 GDSIKALQ-VSARLGRYGLSLQVSDLFRHPKIKDLSPFIRK-SERIIEQGPI------QG 1037 Query: 690 EFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFP 749 + P T QQ W Q + +N + +L G L AL AL LA H ALR ++ Sbjct: 1038 DVPWTPVQQ--WFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKKLAEHHDALRMVYR 1095 Query: 750 LRDGTPVQQVLDIDEARPMLLR-SDLRRQPA--DKRAQAAASALQRFHAQAFRLDSETPL 806 D +Q I E++ LR SDL + + + + + + LQ Q+ L L Sbjct: 1096 NDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ----QSINLQEGPLL 1151 Query: 807 RAMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDY 866 A L + + L L IHH+ DG S I+L++L+A Y+ AG P +Y Sbjct: 1152 HAALFKTLTGDY-LFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTIQLPPKTDSYQEY 1210 Query: 867 AVWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSAAL 926 A +R + S + R+ YWR+ E A LP + P + R LS +L Sbjct: 1211 A--RRIQEYAQSSKLIREEAYWRSVEEQQAA--ELPYEIPHHVNI---DFSKRDSLSFSL 1263 Query: 927 STA-----LRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADR 971 + A L+ + + G +L +LA+ +G S L + G R Sbjct: 1264 TEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGR 1313 >all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1542 Score = 684 bits (1765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/1558 (33%), Positives = 758/1558 (48%), Gaps = 118/1558 (7%) Query: 690 EFPLTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFP 749 PL+ AQQ W+ QL+PDS YN+ + + G++ +++L+ + ++ R LR+ F Sbjct: 4 NLPLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHFL 63 Query: 750 LRDGTPVQQVLDI-DEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLRA 808 DG PV ++ D+ D P++ DL+ P ++ Q + Q F L + R Sbjct: 64 NVDGQPVLRIADVCDVNIPVI---DLQGLPEFEQQQQVQELARTQAQQPFDL-AGLLWRV 119 Query: 809 MLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALE-LQPGDYA 867 LV+L + L L +HHI AD WS+G+++ E++ A+ R AG A E +Q D+A Sbjct: 120 RLVKLGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYVDFA 179 Query: 868 VWQRQRSQPGSPEFQRQLDYWRARLEGAPALLPLPTDRPRQAGAHGGEGQHRWRLSAALS 927 WQR+ + + L+YWR +LE AP +L LPTD PR A + + LSA L+ Sbjct: 180 FWQREWLR--GRVLEEHLEYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSAELT 237 Query: 928 TALRKLAASQGVTLYGAVLALFTLALQRLSGQSDLCVGAPGADRRRRQTQALVAYLINVQ 987 L+ L+ TL+ +LA++ + L R SG D+ VG+P A+R R +T+ L+ N Sbjct: 238 QGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANRNRVETEGLIGCFANTL 297 Query: 988 VVRTRIDERSDFLALMRQVQQAVQEAQAHQDLPLDALVSALQPERVAGANPLFQVKCTQQ 1047 +RT + F L+ +V+ A AHQDLP + LV LQP R +PLFQV Q Sbjct: 298 ALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLVLQ 357 Query: 1048 QAIATVRRMGGLDMRVELQANAESHFDLSLDFTDADEGIDILLAYAPALFDAETVAGFAG 1107 MGG++ +V + + FDL+ ++ +G+ L Y LF A T+ AG Sbjct: 358 NLPLPELDMGGIEWQVIEADSGTAKFDLTWFVSETAQGLSCKLEYNTDLFAATTIERLAG 417 Query: 1108 LLQALAQQVVAAPALALADLQAFPPIS-------AADQVLQPAEDVAACWRRQALAQPDA 1160 L+ L Q VV P + +L + A Q P + + + Q P+ Sbjct: 418 HLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQQCLHELFEAQVRQTPEK 477 Query: 1161 VALRCGAQFISNVQLLQRIDALAQRLHAAGAGPESRVALYAGRGIDFVCGMLAVLDTGAA 1220 +A+ G + ++ +L + + LA L + G PE+ V + R +D + G+LA+L A Sbjct: 478 IAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMIIGLLAILKADGA 537 Query: 1221 YVPLDPQLPAERLAWQLQDSGARWVLHEGQSAPAWLAQAGVPLLSLEAAGTAPASPWTPF 1280 YVPLDP P RLA+ ++DS + VL Q L Q +P++SL+ +P SP P Sbjct: 538 YVPLDPTYPEARLAFIIEDSQMQ-VLLTQQKQLTKLPQLQIPIISLDTPIPSPQSP-VPS 595 Query: 1281 PVHPAQAAYLIYTSGSTGRPKGVLVTRGG---LANYVAAVLEKLALPAAARSMAMISTVA 1337 P P AY+IYTSG+TG PKGV +T L + + + L S +++ Sbjct: 596 PQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYTRAELTGVLAS----TSIC 651 Query: 1338 ADLGHTTLYGALCSGRQLHLITHDLAFDPDGFAAYLHEHAVDVLKIVPSHLQALLHAARP 1397 DL ++ L G + L + L P+ AA V ++ VPS + LL Sbjct: 652 FDLSIFEIFVPLSWGGCVILADNALQL-PELPAA----AQVTLINTVPSAARELLRLNGI 706 Query: 1398 EQVLPRHTLVLGGEATGWPLLERIAALQPACRVLNHYGPSETTVGVLAQEAASASRRAAV 1457 + T+ L GE L++ + RV N YGPSE T S++A Sbjct: 707 AATV--QTVNLAGEPLPKSLVDELYQQSTIERVYNLYGPSEDTTYSTHALIPRNSQQAPT 764 Query: 1458 LPVGSALAGVQAWVLDRQLRRAPVGAVGELYLGGAGLARGYHGRAALTAERFVAHPFASG 1517 +G +A Q ++LD+ L+ PVG GE+YL GAGLARGY R LT ERF+ + Sbjct: 765 --IGQPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKLTDERFIKQSTVNS 822 Query: 1518 QR-----LYRSGDRARYLGDGSIEFLGRIDDQVKIRGHRVEPGEVRQQLLRLAGVVDAAV 1572 Q+ LY++GDRARYL DG+IE+LGR D QVK+RG R+E GE+ L + + A Sbjct: 823 QQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEALLHQHPELTQA-- 880 Query: 1573 LALPAADDAQRLQLHGFIVCAAGAVADPAGWRATLAADLPDYMLPT-LTPVPALPLTANG 1631 +A+ D + +L ++V + A A R LAA LP YMLPT + LPLTANG Sbjct: 881 VAIVRNDTPEHSRLVAYVVPKSHIEA--AELRQFLAAKLPAYMLPTAFVILETLPLTANG 938 Query: 1632 KLDRQALAGLMAGAMAAPQQQVPQVLQAQQAHQAGAPQGELEHKLAAIWAEVLKLPQVGR 1691 K+DR AL +P + AP+ +E +L IW +VL + + Sbjct: 939 KVDRFALP-------------IPDL---SPVTTTTAPRTPIEQQLINIWTQVLGVESISI 982 Query: 1692 DDNFFELGGDSILTLKIVARARKEGLRIAPKAMMEKQTVAAIVAAGAVQGMLAATPAPAV 1751 DNFF LGGDSIL ++ VA+A ++GL + P+ M + QTVA + A L++ P Sbjct: 983 HDNFFRLGGDSILAIQAVAKANQQGLALRPRQMFQYQTVAELAAIVDTDTTLSSEQTPIT 1042 Query: 1752 VAAPADIPLTPVQHWFFEQGFATPQHWNQSVLLNA-PGLDAGVLRRALALLAQRHESLRL 1810 ++PLTP+Q WFFEQ HWNQ++LL L+ LR+AL L H+ LR Sbjct: 1043 ----GEVPLTPIQQWFFEQNLVDAHHWNQAILLEVHQSLNPDYLRQALDQLLAHHDGLRS 1098 Query: 1811 RFVQEGGQWRQR----------------------RG--PALLPL--------EIIDGDE- 1837 F Q WRQ RG A LPL D E Sbjct: 1099 HFQQTPDGWRQFVADINQLHNTQKPNPQPLLYKGRGEIKASLPLGERLGEGFYYFDMSEL 1158 Query: 1838 --------PGAIAAAGELVQRSLDLAQGPLMAAAWIRLDAQGKQGRLLLAGHHLVVDGVS 1889 IA +Q S +L PL+ A+ + + RLLL HHL++DG+S Sbjct: 1159 TNLHPEKVSDTIANIANDLQASFNLETPPLLRLAYFDC-GETQNHRLLLIFHHLIIDGIS 1217 Query: 1890 WRVLLDDLAGLYHTLQQGGTPAELPPATDLY-TWSQALRAHAQRPAVTDQLAYWRSVVDT 1948 WRV L+DL L + G +LPP T Y W+ L+ H + YW S Sbjct: 1218 WRVFLEDLQ-LAYQQLSQGQQIQLPPKTTSYQQWANKLQEHTWSADLQAAFNYWTSPTWQ 1276 Query: 1949 PEPPLADATANLAGRAADA---GFVLDADATARLLALGAHADPAVRVAPQDLLLAVLARV 2005 PPL A + AD L T LL H A R D+LL L Sbjct: 1277 QIPPLPVDYAPGSNTMADVDTYSTFLSVTDTQNLLQEVPH---AYRTQINDVLLTALVLA 1333 Query: 2006 LCEWSGRDSLLFELEGHGREDIPGGLDVSRATGWFTALYPVRLAPGATSTSIPAALEAVR 2065 W+G + LL ELEGHGRED+ +++SR GWFT+L+PV L S + +L+A++ Sbjct: 1334 FQTWTGENRLLVELEGHGREDLFPSINLSRTMGWFTSLFPV-LLDIYPSADLGISLKAIK 1392 Query: 2066 AQLRAVPANGLGYGLLRYLSGQG--QELAQGAQPQITFNYLGHFDHRI-EPAGWTLADEY 2122 QLR +P G+ YGLLRYL+ + PQ+ FNYLG D E + +T A E Sbjct: 1393 EQLRQIPDRGISYGLLRYLASPTIRDTIKAIPLPQVRFNYLGQSDQIFSENSLFTPASES 1452 Query: 2123 AGAQRAADSRRRCLFEAIARVQQGRLQWQWTYCKDLHAAAEMRALQERLRTELMRWIE 2180 G R++ +R L E + V G+L+ WTY K LH + L E + L+ I+ Sbjct: 1453 IGHSRSSRGKRNTLIEINSIVTGGKLRCDWTYSKQLHHRQTIATLAENYQQILLSLIQ 1510 Score = 504 bits (1298), Expect = e-141, Method: Compositional matrix adjust. Identities = 479/1573 (30%), Positives = 718/1573 (45%), Gaps = 169/1573 (10%) Query: 2230 LEAVWRDAVRRHPILRTGFRQQGDAPEQWVAQPV-LHWRALDLSGQPPQQQAQLEQ-IAA 2287 L+ + + VRR ILR+ F P +A ++ +DL G P +Q Q Q +A Sbjct: 44 LQRSFTEVVRRQEILRSHFLNVDGQPVLRIADVCDVNIPVIDLQGLPEFEQQQQVQELAR 103 Query: 2288 AELARGFDLAQPGLM-RLVLAKLGEGRHHLIWTRHHLLLDGWSSAQLFAEIVRAYAGEEI 2346 + + FDLA GL+ R+ L KLGEG L+ T HH++ D WS L EI RA+A E Sbjct: 104 TQAQQPFDLA--GLLWRVRLVKLGEGNQVLLLTLHHIIADAWSVGLLVREISRAFA-ERP 160 Query: 2347 AAPTLAYR-----HYID-------WLQARDGAAARDFWRAQLQH----LEEPTLLAGALP 2390 A R Y+D WL+ R ++WR QL+ LE PT P Sbjct: 161 AGKAQRRREEERIQYVDFAFWQREWLRGRVLEEHLEYWRGQLESAPVMLELPT----DYP 216 Query: 2391 RPREDASGHAEHLAAISPAQWQALCQAAKAMRITPGTLLQGAWALVLQRCCGQSAVAFGV 2450 RP + A + +S Q L ++ T L W ++L R G + G Sbjct: 217 RPAVQSFRGAVYGFGLSAELTQGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGS 276 Query: 2451 TVADRP-AELEGIESTLGLFINTLPLAVRLHAPQDCSDWLR--------ALLHQNLAMRE 2501 +A+R E EG+ +G F NTL L L A +D L A HQ+L + Sbjct: 277 PIANRNRVETEGL---IGCFANTLALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQ 333 Query: 2502 FAHAPLYEIQRWSGRAGQALFDSILVLENYPMDEAIDRAADYGLHLSGLRLHEQTS-YPL 2560 +Q + LF +LVL+N P+ E +D G+ + T+ + L Sbjct: 334 LVDV----LQPVRSLSHSPLFQVMLVLQNLPLPE-LDMG---GIEWQVIEADSGTAKFDL 385 Query: 2561 T--VVATAQDGLSLRLGYDRSRFGAHQVAQLA---DWLAQALVTLTTAGARLGDCALGSA 2615 T V TAQ GLS +L Y+ F A + +LA + L QA+V + + L + Sbjct: 386 TWFVSETAQ-GLSCKLEYNTDLFAATTIERLAGHLETLLQAVVL--NPEQHINELPLLTT 442 Query: 2616 TQRQQALDWSLNGQRFDGQEPVHRLFEQQASRRPDAIALQADGAHWTYGQLNAAANALAR 2675 ++QQ W+ QR Q+ +H LFE Q + P+ IA+ TY +LN AN LA Sbjct: 443 VEQQQLAQWNAT-QRQYPQQCLHELFEAQVRQTPEKIAVIWGEKQLTYQELNTKANQLAC 501 Query: 2676 RLQAAGVGPDTVVALLAERSAAMVTALLAVLKAGAAYLPLDPDYPAERLAWMLEDARPAC 2735 LQ+ GV P+T V + +RS M+ LLA+LKA AY+PLDP YP RLA+++ED++ Sbjct: 502 HLQSLGVQPETPVGICVDRSLDMIIGLLAILKADGAYVPLDPTYPEARLAFIIEDSQMQV 561 Query: 2736 LLSHRGLHHRLALPDTLLLELEDQLPGSQRGDDPQHNPQPPLHGEHLAYVIYTSGSTGRP 2795 LL+ + +L ++ L+ +P Q + +LAY+IYTSG+TG P Sbjct: 562 LLTQQKQLTKLPQLQIPIISLDTPIPSPQSPVPSPQS------PTNLAYIIYTSGTTGIP 615 Query: 2796 KGAGNSHRALYNRLRWMQQAYALQEGDAVLQKTPFGFDVSVWEFLWPLMTGARLVMAPPG 2855 KG +H++ + W ++ Y E VL T FD+S++E PL G +++A Sbjct: 616 KGVAITHQSPVTLMYWAREIYTRAELTGVLASTSICFDLSIFEIFVPLSWGGCVILA--- 672 Query: 2856 AHRDPAELAALIREQGVSTLHFVPSMLQAFLASGQAAACTSLRQVICSGEALPAEARDQF 2915 + +L L V+ ++ VPS + L AA +++ V +GE LP D+ Sbjct: 673 --DNALQLPELPAAAQVTLINTVPSAARELLRLNGIAA--TVQTVNLAGEPLPKSLVDEL 728 Query: 2916 FALLPQAALHNLYGPTEAAIDVTHWTCQHGDRGPVPIGQPISGLRAVVLDADLNVLPCGV 2975 + ++NLYGP+E TH + IGQPI+ + +LD +L +P G+ Sbjct: 729 YQQSTIERVYNLYGPSEDTTYSTHALIPRNSQQAPTIGQPIANTQVYILDQNLQPVPVGI 788 Query: 2976 AGELYLGGIGLARGYLGRPGLTAERFVASPFGQGER-----LYRTGDLVRWREDGQIDYL 3030 GE+YL G GLARGY RP LT ERF+ ++ LY+TGD R+ DG I+YL Sbjct: 789 PGEIYLSGAGLARGYWKRPKLTDERFIKQSTVNSQQSTVNTLYKTGDRARYLPDGNIEYL 848 Query: 3031 GRLDHQVKIRGLRIELGEIEAQLLALDEVEEAV-VVAHEHGAGPVLAGYVASRRWQRQDA 3089 GR DHQVK+RG RIELGEIEA L E+ +AV +V ++ L YV + +A Sbjct: 849 GRFDHQVKLRGFRIELGEIEALLHQHPELTQAVAIVRNDTPEHSRLVAYVVPK--SHIEA 906 Query: 3090 ATLKQALAARLPDYMVPAVLTLLPTLPLNANGKIDRKALPAPRLHSEDFAYAAPQGQVEQ 3149 A L+Q LAA+LP YM+P +L TLPL ANGK+DR ALP P L S AP+ +EQ Sbjct: 907 AELRQFLAAKLPAYMLPTAFVILETLPLTANGKVDRFALPIPDL-SPVTTTTAPRTPIEQ 965 Query: 3150 RLAQIWQALLGLERVGRFDHFFELGGHSLLAASLVARLRYQGEAGVGVALPLRLVFAYPR 3209 +L IW +LG+E + D+FF LGG S+LA VA+ Q G+AL R +F Y Sbjct: 966 QLINIWTQVLGVESISIHDNFFRLGGDSILAIQAVAKANQQ-----GLALRPRQMFQYQT 1020 Query: 3210 LHEMAACIEGQAAIAAQQLPAAPAPLLQPGQRGAQALLSPAQHRLWLVDRLSGEADAAAY 3269 + E+AA ++ ++++Q P + L+P Q W ++ DA + Sbjct: 1021 VAELAAIVDTDTTLSSEQTPIT-----------GEVPLTPIQQ--WFFEQ--NLVDAHHW 1065 Query: 3270 NMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGEDGDG-----NPVATLH------- 3317 N + L + ++ L QAL L+A HD LR+ F + DG + LH Sbjct: 1066 NQAILLEVHQSLNPDYLRQALDQLLAHHDGLRSHFQQTPDGWRQFVADINQLHNTQKPNP 1125 Query: 3318 -PFDFSLEQHDLAALPPPQR--------------DLQLDRLRRSHAA------ARFALRQ 3356 P + A+LP +R +L +++ + A A F L Sbjct: 1126 QPLLYKGRGEIKASLPLGERLGEGFYYFDMSELTNLHPEKVSDTIANIANDLQASFNLET 1185 Query: 3357 PPLLRAALVRLA-PQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLPL 3415 PPLLR A Q LLL HH++ DG S + +E++ AY L +G+ PP Sbjct: 1186 PPLLRLAYFDCGETQNHRLLLIFHHLIIDGISWRVFLEDLQLAYQQLSQGQQIQLPPKTT 1245 Query: 3416 QYADYAAWQVAGAGSRMLEDSIAWWRD-TLAGVPATP--YLPSTRPCPARATHA------ 3466 Y +A S L+ + +W T +P P Y P + T++ Sbjct: 1246 SYQQWANKLQEHTWSADLQAAFNYWTSPTWQQIPPLPVDYAPGSNTMADVDTYSTFLSVT 1305 Query: 3467 -GQRLRMHLPAHLRSGVQALARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRS- 3524 Q L +P R+ + V A++LA W +G +V + GR Sbjct: 1306 DTQNLLQEVPHAYRTQI------NDVLLTALVLAFQTW-----TGENRLLVELEGHGRED 1354 Query: 3525 ---HPDLERLVGFFVNVLPLRLRPQALAPRASFAAWLRHCADVAVNAFDHQ-EPGFDRIV 3580 +L R +G+F ++ P+ L + P A L+ + D G R + Sbjct: 1355 LFPSINLSRTMGWFTSLFPVLLD---IYPSADLGISLKAIKEQLRQIPDRGISYGLLRYL 1411 Query: 3581 EAAGVPRERRWNPLVQVLFVLQNTPRAALALPGVRAELLEPL--ENWSKFDLALFVEDHA 3638 + + + PL QV F + + E + S+ +E ++ Sbjct: 1412 ASPTIRDTIKAIPLPQVRFNYLGQSDQIFSENSLFTPASESIGHSRSSRGKRNTLIEINS 1471 Query: 3639 EAGDAEDGPGWRADWVYADALFDAATVAALGRDWQRLLEQVLASPWTPLDAALPSSPSDT 3698 G R DW Y+ L T+A L ++Q++L ++ TP + +PSD Sbjct: 1472 IVT----GGKLRCDWTYSKQLHHRQTIATLAENYQQILLSLIQHCLTPEVSGF--TPSDF 1525 Query: 3699 KAEVPSQVLLDEI 3711 SQ LD++ Sbjct: 1526 PQMDFSQDELDKL 1538 Score = 201 bits (512), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 149/439 (33%), Positives = 222/439 (50%), Gaps = 17/439 (3%) Query: 3247 LSPAQHRLWLVDRLSGEADAAAYNMSAALMLEGVVDAVLLEQALRLLVARHDILRTGFGE 3306 LS AQ R W++ +L E D+ YN+ A+ + G + L+++ +V R +ILR+ F Sbjct: 7 LSFAQQRFWILAQL--EPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHF-L 63 Query: 3307 DGDGNPVATLHPF-DFSLEQHDLAALPPPQRDLQLDRLRRSHAAARFALRQPPLLRAALV 3365 + DG PV + D ++ DL LP ++ Q+ L R+ A F L L R LV Sbjct: 64 NVDGQPVLRIADVCDVNIPVIDLQGLPEFEQQQQVQELARTQAQQPFDLAGL-LWRVRLV 122 Query: 3366 RLAPQQQVLLLAIHHIVADGWSVALMMEEIAAAYSALQEGRPYAPPPLP-LQYADYAAWQ 3424 +L QVLLL +HHI+AD WSV L++ EI+ A++ G+ +QY D+A WQ Sbjct: 123 KLGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYVDFAFWQ 182 Query: 3425 VAGAGSRMLEDSIAWWRDTLAGVPATPYLPSTRPCPARATHAGQRLRMHLPAHLRSGVQA 3484 R+LE+ + +WR L P LP+ P PA + G L A L G+Q Sbjct: 183 REWLRGRVLEEHLEYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSAELTQGLQG 242 Query: 3485 LARREGVTAYAVLLASFAWLLHQRSGAGDFVVGTDVAGRSHPDLERLVGFFVNVLPLRLR 3544 L+RR T + LLA + LL++ SG D VVG+ +A R+ + E L+G F N L LR Sbjct: 243 LSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANRNRVETEGLIGCFANTLALR-- 300 Query: 3545 PQALAPRASFAAWLRHCADVAVNAFDHQEPGFDRIVEAAGVPRERRWNPLVQVLFVLQNT 3604 L+ SFA L A+ A+ HQ+ F+++V+ R +PL QV+ VLQN Sbjct: 301 -TDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLVLQNL 359 Query: 3605 PRAALALPGVRAELLEPLENWSKFDLALFVEDHAEAGDAEDGPGWRADWVYADALFDAAT 3664 P L + G+ +++E +KFDL FV + A+ G Y LF A T Sbjct: 360 PLPELDMGGIEWQVIEADSGTAKFDLTWFVSETAQ--------GLSCKLEYNTDLFAATT 411 Query: 3665 VAALGRDWQRLLEQVLASP 3683 + L + LL+ V+ +P Sbjct: 412 IERLAGHLETLLQAVVLNP 430