BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0306.p (873 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0120 [C] COG1048 Aconitase A Rso Ralstonia solanacearum 1545 0.0 PA0794 [C] COG1048 Aconitase A Pae Pseudomonas aeruginosa 1526 0.0 NMA2052 [C] COG1048 Aconitase A NmA Neisseria meningitidis Z2491 1424 0.0 NMB0433 [C] COG1048 Aconitase A Nme Neisseria meningitidis MC58 1419 0.0 VC1338 [C] COG1048 Aconitase A Vch Vibrio cholerae 1396 0.0 STM1712 [C] COG1048 Aconitase A Sty Salmonella typhimurium LT2 723 0.0 APE1618 [C] COG1048 Aconitase A Ape Aeropyrum pernix 716 0.0 RP799 [C] COG1048 Aconitase A Rpr Rickettsia prowazekii 716 0.0 MA0250 [C] COG1048 Aconitase A Mac Methanosarcina acetivorans st... 715 0.0 YPO2221 [C] COG1048 Aconitase A Ype Yersinia pestis 712 0.0 >RSp0120 [C] COG1048 Aconitase A Rso Ralstonia solanacearum Length = 865 Score = 1545 bits (4000), Expect = 0.0, Method: Compositional matrix adjust. Identities = 749/865 (86%), Positives = 793/865 (91%), Gaps = 1/865 (0%) Query: 1 MNTQYRKQLPGTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPATLTDSLRQ 60 MNT YRK LPGT LDYFDARAAVEAI PGA+DTLPYTSRVLAENLVRRCDPATL DSLRQ Sbjct: 1 MNTAYRKPLPGTSLDYFDARAAVEAIAPGAYDTLPYTSRVLAENLVRRCDPATLADSLRQ 60 Query: 61 LIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIVDH 120 LIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIA+ GGDPA+VNPVVPVQLIVDH Sbjct: 61 LIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIAEQGGDPAQVNPVVPVQLIVDH 120 Query: 121 SLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLEKM 180 SLAVECGGDDP AF KNRAIEDRRNEDRFHFI WTKLAF+NVDVIP GNGIMHQINLEKM Sbjct: 121 SLAVECGGDDPDAFAKNRAIEDRRNEDRFHFIEWTKLAFKNVDVIPAGNGIMHQINLEKM 180 Query: 181 SPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGV 240 SPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDI+GV Sbjct: 181 SPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIVGV 240 Query: 241 ELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGA 300 ELTG RQPGITATDIVL+LTEFLR+QKVVGAYLEF+G+GAA LTLGDRATISNMAPEYGA Sbjct: 241 ELTGERQPGITATDIVLALTEFLRQQKVVGAYLEFHGEGAARLTLGDRATISNMAPEYGA 300 Query: 301 TAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTVVR 360 TAAMFSID QT+DYL+LTGR DEQV+LVETYAK AGLWSDTL YERVLRFD+S+VVR Sbjct: 301 TAAMFSIDPQTLDYLRLTGRADEQVRLVETYAKAAGLWSDTLKHAAYERVLRFDVSSVVR 360 Query: 361 TLAGPSNPHKRLPVSELAAQGIAGKVENEPGKMPDGAVIIAAITSCTNTSNPRNVIAAGL 420 +AGPSNPH R+ ++LAA+GIAG+ ++ PG+MPDGAVIIAAITSCTNTSNPRNVIAAGL Sbjct: 361 NMAGPSNPHARVATTDLAAKGIAGQWDDVPGQMPDGAVIIAAITSCTNTSNPRNVIAAGL 420 Query: 421 LARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCNGMSG 480 LARNANRLGL RKPWVKSSLAPGSKAV LYLE AGL +LE LGFGIVAFACTTCNGMSG Sbjct: 421 LARNANRLGLTRKPWVKSSLAPGSKAVALYLEAAGLKTELEALGFGIVAFACTTCNGMSG 480 Query: 481 ALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIE 540 ALDP IQQEII+RDLY+TAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGT+RFDIE Sbjct: 481 ALDPTIQQEIINRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTVRFDIE 540 Query: 541 QDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQSVSPLY 600 +D G +G+ I LKD+WPSD EIDA+V AAVKP+QFR VY PMF R + + SVSPLY Sbjct: 541 RDSFGTGPDGQPITLKDLWPSDAEIDAIVRAAVKPEQFRQVYIPMFDQRSEATASVSPLY 600 Query: 601 DWRPQSTYIRRPPYWEGALAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAAGEYLA 660 DWR QSTYIRRPPYWEGALAGERTL G+RPLAVLGDNITTDHLSPSNAIL DSAAGEYLA Sbjct: 601 DWRAQSTYIRRPPYWEGALAGERTLRGLRPLAVLGDNITTDHLSPSNAILADSAAGEYLA 660 Query: 661 KMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPEGKVMR 720 KMGLPEEDFNSYATHRGDHLTAQRATFANP L NEM DG V++GSLAR+EPEGKV R Sbjct: 661 KMGLPEEDFNSYATHRGDHLTAQRATFANPTLRNEMA-VVDGEVKKGSLARIEPEGKVTR 719 Query: 721 MWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGM 780 MWE IE YM RKQPLI+IAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGM Sbjct: 720 MWEAIEAYMARKQPLIVIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGM 779 Query: 781 GVLPLEFKAGENRNTYAIDGTETYDVIGQRRPRADLTLVIHRKNGERVEVPVTCRLDTAE 840 GVLPLEFK G R T IDGTET+DVIG R PRADLTLVIHRKNGERV+VPVTCRLDTAE Sbjct: 780 GVLPLEFKPGTTRITLGIDGTETFDVIGARTPRADLTLVIHRKNGERVDVPVTCRLDTAE 839 Query: 841 EVSIYEAGGVLQRFAQDFLEASANA 865 EVSIYEAGGVLQRFAQDFLE++ A Sbjct: 840 EVSIYEAGGVLQRFAQDFLESAKEA 864 >PA0794 [C] COG1048 Aconitase A Pae Pseudomonas aeruginosa Length = 868 Score = 1526 bits (3951), Expect = 0.0, Method: Compositional matrix adjust. Identities = 738/867 (85%), Positives = 794/867 (91%), Gaps = 6/867 (0%) Query: 1 MNTQYRKQLPGTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPATLTDSLRQ 60 MN+ +RK LPGTRLDYFDAR AVEAI+PGA+ LPYTSRVLAENLVRRCDPATL SLRQ Sbjct: 1 MNSAHRKPLPGTRLDYFDAREAVEAIQPGAYAKLPYTSRVLAENLVRRCDPATLEASLRQ 60 Query: 61 LIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIVDH 120 L+ERKR+LDFPW+PARVVCHDILGQTALVDLAGLRDAIAD GGDPA+VNPVVPVQLIVDH Sbjct: 61 LVERKRDLDFPWYPARVVCHDILGQTALVDLAGLRDAIADKGGDPAQVNPVVPVQLIVDH 120 Query: 121 SLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLEKM 180 SLAVECGG DP+AF KNRAIEDRRNEDRFHFI+WTK AF NVDVIPPGNGIMHQINLEKM Sbjct: 121 SLAVECGGYDPEAFAKNRAIEDRRNEDRFHFIDWTKQAFRNVDVIPPGNGIMHQINLEKM 180 Query: 181 SPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGV 240 SPVI A+DGVAFPDT VGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDI+GV Sbjct: 181 SPVIQARDGVAFPDTCVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIVGV 240 Query: 241 ELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGA 300 EL+GRRQPGITATD+VL+LTEFLRKQKVVGAYLEFYG+GA+SLTLGDRATISNMAPEYGA Sbjct: 241 ELSGRRQPGITATDVVLALTEFLRKQKVVGAYLEFYGEGASSLTLGDRATISNMAPEYGA 300 Query: 301 TAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTVVR 360 TAAMF+IDQQTIDYL+LTGR+DEQV LVE YA+ AGLW+D+L EYERVL+FDLS+VVR Sbjct: 301 TAAMFAIDQQTIDYLRLTGRDDEQVALVEAYARTAGLWADSLVDAEYERVLKFDLSSVVR 360 Query: 361 TLAGPSNPHKRLPVSELAAQGIAG-----KVENEPGKMPDGAVIIAAITSCTNTSNPRNV 415 +AGPSNPH R+ SELAA+GIAG + E G MPDGAVIIAAITSCTNTSNPRNV Sbjct: 361 NMAGPSNPHARVATSELAAKGIAGNLERARAEEAEGLMPDGAVIIAAITSCTNTSNPRNV 420 Query: 416 IAAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTC 475 IAAGLLARNA+RLGL RKPWVK+SLAPGSK V YL EAGL LE LGFG+VA+ACT+C Sbjct: 421 IAAGLLARNADRLGLVRKPWVKTSLAPGSKVVTEYLREAGLLPHLEALGFGVVAYACTSC 480 Query: 476 NGMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 535 NGMSGALDP IQ+EI++RDLY+TAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI Sbjct: 481 NGMSGALDPAIQREIVERDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTI 540 Query: 536 RFDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQS 595 RFDIE+DVLGV +G+EIRLKD+WPSDEEIDAVV AAVKP+QFR VY PMF + Sbjct: 541 RFDIERDVLGVV-DGKEIRLKDLWPSDEEIDAVVRAAVKPEQFRQVYIPMFDITHGEREK 599 Query: 596 VSPLYDWRPQSTYIRRPPYWEGALAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAA 655 V PLY WRP STYIRRPPYWEGALAGERTL GMRPLAVL DNITTDHLSPSNAIL DSAA Sbjct: 600 VDPLYAWRPTSTYIRRPPYWEGALAGERTLRGMRPLAVLPDNITTDHLSPSNAILADSAA 659 Query: 656 GEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPE 715 GEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMV+ ADGSV+QGSLAR+EPE Sbjct: 660 GEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVRNADGSVKQGSLARVEPE 719 Query: 716 GKVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRT 775 GKVMRMWE IETYMERKQPLII+AGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRT Sbjct: 720 GKVMRMWEAIETYMERKQPLIIVAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRT 779 Query: 776 NLIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRRPRADLTLVIHRKNGERVEVPVTCR 835 NLIGMGVLPLEFK G R T IDG+ET+DV+G RRPRADLTLVIHR++GER+EVPVTCR Sbjct: 780 NLIGMGVLPLEFKPGTTRLTLGIDGSETFDVLGARRPRADLTLVIHRRDGERLEVPVTCR 839 Query: 836 LDTAEEVSIYEAGGVLQRFAQDFLEAS 862 LD+ EEVSIYEAGGVLQRFAQDFLEA+ Sbjct: 840 LDSDEEVSIYEAGGVLQRFAQDFLEAA 866 >NMA2052 [C] COG1048 Aconitase A NmA Neisseria meningitidis Z2491 Length = 868 Score = 1424 bits (3687), Expect = 0.0, Method: Compositional matrix adjust. Identities = 701/867 (80%), Positives = 771/867 (88%), Gaps = 8/867 (0%) Query: 2 NTQYRKQLPGTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPA---TLTDSL 58 N +YRK LPGT L+Y+DARAA E I+PG++D LPYTSR+LAENLV R D TL L Sbjct: 4 NQRYRKPLPGTDLEYYDARAACEGIKPGSYDKLPYTSRILAENLVNRADKVDLPTLQSWL 63 Query: 59 RQLIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIV 118 QLIE K+E+DFPW+PARVVCHDILGQTALVDLAGLRDAIA+ GGDPAKVNPVV QLIV Sbjct: 64 GQLIEGKQEIDFPWYPARVVCHDILGQTALVDLAGLRDAIAEKGGDPAKVNPVVQTQLIV 123 Query: 119 DHSLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLE 178 DHSLAVECGG DP AF KNR IEDRRNEDRFHFINWTK AFENVDVIP GNGIMHQINLE Sbjct: 124 DHSLAVECGGYDPDAFRKNREIEDRRNEDRFHFINWTKTAFENVDVIPAGNGIMHQINLE 183 Query: 179 KMSPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDII 238 KMSPV+ K+GVAFPDT VGTDSHTPHVDALGVI++GVGGLEAE VMLGRAS MRLPDI+ Sbjct: 184 KMSPVVQVKNGVAFPDTCVGTDSHTPHVDALGVISVGVGGLEAETVMLGRASMMRLPDIV 243 Query: 239 GVELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEY 298 GVEL G+R+ GITATDIVL+LTEFLRK++VVGA++EF+G+GA SL++GDRATISNM PE+ Sbjct: 244 GVELNGKRKAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLSIGDRATISNMTPEF 303 Query: 299 GATAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTV 358 GATAAMF+ID+QTIDYLKLTGR+D QVKLVETYAK AGLW+D L Y RVL+FDLS+V Sbjct: 304 GATAAMFAIDEQTIDYLKLTGRDDAQVKLVETYAKTAGLWADALKTAVYPRVLKFDLSSV 363 Query: 359 VRTLAGPSNPHKRLPVSELAAQGIAGKVENEP--GKMPDGAVIIAAITSCTNTSNPRNVI 416 R +AGPSNPH R ++LA +G+A E EP G+MPDGAVIIAAITSCTNTSNPRNV+ Sbjct: 364 TRNMAGPSNPHARFATADLAGKGLAKPYE-EPSDGQMPDGAVIIAAITSCTNTSNPRNVV 422 Query: 417 AAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCN 476 AA LLARNANRLGL RKPWVKSS APGSK E+YL+EA L ++EKLGFGIVAFACTTCN Sbjct: 423 AAALLARNANRLGLQRKPWVKSSFAPGSKVAEIYLKEADLLPEMEKLGFGIVAFACTTCN 482 Query: 477 GMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIR 536 GMSGALDPKIQ+EIIDRDLY+TAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYA+AG+IR Sbjct: 483 GMSGALDPKIQKEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYALAGSIR 542 Query: 537 FDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQSV 596 FDIE DVLGV A+G+EIRLKDIWP+DEEIDA+V VKPQQFR+VY PMF + ++ Sbjct: 543 FDIENDVLGV-ADGKEIRLKDIWPTDEEIDAIVAEYVKPQQFRDVYIPMFDTGTAQ-KAP 600 Query: 597 SPLYDWRPQSTYIRRPPYWEGALAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAAG 656 SPLYDWRP STYIRRPPYWEGALAGERTLSGMRPLA+L DNITTDHLSPSNAIL SAAG Sbjct: 601 SPLYDWRPMSTYIRRPPYWEGALAGERTLSGMRPLAILPDNITTDHLSPSNAILASSAAG 660 Query: 657 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPEG 716 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMV+ DGSV+QGSLAR+EPEG Sbjct: 661 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVRNEDGSVRQGSLARVEPEG 720 Query: 717 KVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN 776 + MRMWE IETYM RKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN Sbjct: 721 QTMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN 780 Query: 777 LIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRRPRADLTLVIHRKNGERVEVPVTCRL 836 LIGMGVLPL+FK G NR+T +DGTETYDV+G+R PR DLTLVIHRKNGE VEVP+TCRL Sbjct: 781 LIGMGVLPLQFKPGTNRHTLQLDGTETYDVVGERTPRCDLTLVIHRKNGETVEVPITCRL 840 Query: 837 DTAEEVSIYEAGGVLQRFAQDFLEASA 863 DTAEEV +YEAGGVLQRFAQDFLE +A Sbjct: 841 DTAEEVLVYEAGGVLQRFAQDFLEGNA 867 >NMB0433 [C] COG1048 Aconitase A Nme Neisseria meningitidis MC58 Length = 868 Score = 1419 bits (3672), Expect = 0.0, Method: Compositional matrix adjust. Identities = 701/867 (80%), Positives = 769/867 (88%), Gaps = 8/867 (0%) Query: 2 NTQYRKQLPGTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPA---TLTDSL 58 N +YRK LPGT L+Y+DARAA E I+PG++D LPYTSR+LAENLV R D TL L Sbjct: 4 NQRYRKPLPGTDLEYYDARAACEDIKPGSYDKLPYTSRILAENLVNRADKVDLPTLQSWL 63 Query: 59 RQLIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIV 118 QLIE K+E+DFPW+PARVVCHDILGQTALVDLAGLRDAIA+ GGDPAKVNPVV QLIV Sbjct: 64 GQLIEGKQEIDFPWYPARVVCHDILGQTALVDLAGLRDAIAEKGGDPAKVNPVVQTQLIV 123 Query: 119 DHSLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLE 178 DHSLAVECGG DP AF KNR IEDRRNEDRFHFINWTK AFENVDVIP GNGIMHQINLE Sbjct: 124 DHSLAVECGGYDPDAFRKNREIEDRRNEDRFHFINWTKTAFENVDVIPAGNGIMHQINLE 183 Query: 179 KMSPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDII 238 KMSPV+ K+GVAFPDT VGTDSHTPHVD+LGVI++GVGGLEAE VMLGRAS MRLPDI+ Sbjct: 184 KMSPVVQVKNGVAFPDTCVGTDSHTPHVDSLGVISVGVGGLEAETVMLGRASMMRLPDIV 243 Query: 239 GVELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEY 298 GVEL G+RQ GITATDIVL+LTEFLRK++VVGA++EF+G+GA SL++GDRATISNM PE+ Sbjct: 244 GVELNGKRQAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLSIGDRATISNMTPEF 303 Query: 299 GATAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTV 358 GATAAMF+ID+QTIDYLKLTGR+D QVKLVETYAK AGLW+D L Y RVL+FDLS+V Sbjct: 304 GATAAMFAIDEQTIDYLKLTGRDDAQVKLVETYAKTAGLWADALKTAVYPRVLKFDLSSV 363 Query: 359 VRTLAGPSNPHKRLPVSELAAQGIAGKVENEP--GKMPDGAVIIAAITSCTNTSNPRNVI 416 R +AGPSNPH R ++LAA+G+A E EP G+MPDG+VIIAAITSCTNTSNPRNV+ Sbjct: 364 TRNMAGPSNPHARFATADLAAKGLAKPYE-EPSDGQMPDGSVIIAAITSCTNTSNPRNVV 422 Query: 417 AAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCN 476 AA LLARNANRLGL RKPWVKSS APGSK E+YL+EAGL ++EKLGFGIVAFACTTCN Sbjct: 423 AAALLARNANRLGLKRKPWVKSSFAPGSKVAEIYLKEAGLLPEMEKLGFGIVAFACTTCN 482 Query: 477 GMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIR 536 GMSGALDPKIQ+EIIDRDLY+TAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYA+AG+IR Sbjct: 483 GMSGALDPKIQKEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYALAGSIR 542 Query: 537 FDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQSV 596 FDIE DVLGV A+G+EIRLKDIWP+DEEIDAVV VKPQQFR+VY PMF + ++ Sbjct: 543 FDIENDVLGV-ADGKEIRLKDIWPADEEIDAVVAEYVKPQQFRDVYVPMFDTGTAQ-KAP 600 Query: 597 SPLYDWRPQSTYIRRPPYWEGALAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAAG 656 SPLYDWRP STYIRRPPYWEGALAGERTL GMRPLA+L DNITTDHLSPSNAIL SAAG Sbjct: 601 SPLYDWRPMSTYIRRPPYWEGALAGERTLRGMRPLAILPDNITTDHLSPSNAILAVSAAG 660 Query: 657 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPEG 716 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVK DGSV+QGS AR+EPEG Sbjct: 661 EYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKNEDGSVRQGSFARVEPEG 720 Query: 717 KVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN 776 + MRMWE IETYM RKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN Sbjct: 721 ETMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTN 780 Query: 777 LIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRRPRADLTLVIHRKNGERVEVPVTCRL 836 LIGMGVLPL+FK NR+T +DGTETYDV+G+R PR DLTLVIHRKNGE VEVPVTC L Sbjct: 781 LIGMGVLPLQFKPDTNRHTLQLDGTETYDVVGERTPRCDLTLVIHRKNGETVEVPVTCCL 840 Query: 837 DTAEEVSIYEAGGVLQRFAQDFLEASA 863 DTAEEV +YEAGGVLQRFAQDFLE +A Sbjct: 841 DTAEEVLVYEAGGVLQRFAQDFLEGNA 867 >VC1338 [C] COG1048 Aconitase A Vch Vibrio cholerae Length = 868 Score = 1396 bits (3614), Expect = 0.0, Method: Compositional matrix adjust. Identities = 670/869 (77%), Positives = 760/869 (87%), Gaps = 13/869 (1%) Query: 1 MNTQYRKQLP----GTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPATLTD 56 MN+ YRK L +++D+FD RAAVEA++PGA+ TLPYT+R+LAENLVRRC P L++ Sbjct: 1 MNSLYRKALSPSPAQSQVDFFDTRAAVEALKPGAYQTLPYTARILAENLVRRCPPEQLSE 60 Query: 57 SLRQLIERKRELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQL 116 SL Q+IERKR+LDFPW+PARVVCHDILGQTALVDLAGLRDAIA+ GGDPA+VNPVV QL Sbjct: 61 SLLQIIERKRDLDFPWYPARVVCHDILGQTALVDLAGLRDAIAEQGGDPAQVNPVVETQL 120 Query: 117 IVDHSLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQIN 176 IVDHSLAVE G DP AF KNRA+EDRRNEDRFHFI W K AF+NV VIP GNGIMHQIN Sbjct: 121 IVDHSLAVEYSGCDPDAFEKNRAVEDRRNEDRFHFIEWCKTAFKNVSVIPAGNGIMHQIN 180 Query: 177 LEKMSPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPD 236 LEKMSPVI K+GVAFPD+ VGTDSHTPHVDALGV+AIGVGGLEAE VMLGR S MRLPD Sbjct: 181 LEKMSPVIQVKEGVAFPDSCVGTDSHTPHVDALGVLAIGVGGLEAETVMLGRPSMMRLPD 240 Query: 237 IIGVELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAP 296 I+GV+LTG RQPGITATDIVL+LTEFLR+++VV AYLEF+G+GA +LT+GDRATISNM P Sbjct: 241 IVGVKLTGARQPGITATDIVLALTEFLRRERVVSAYLEFFGEGAKALTIGDRATISNMTP 300 Query: 297 EYGATAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLS 356 EYGATA MF ID+QTI YLKLTGRE EQV LVE+YAK AGLW+D+L EYERVL FDLS Sbjct: 301 EYGATAGMFYIDEQTIQYLKLTGREPEQVALVESYAKAAGLWADSLEHAEYERVLEFDLS 360 Query: 357 TVVRTLAGPSNPHKRLPVSELAAQGIA-----GKVENEPGKMPDGAVIIAAITSCTNTSN 411 +V R LAGPSNPH+RLP +L+A+GIA + + G MPDGAVIIAAITSCTNTSN Sbjct: 361 SVERNLAGPSNPHRRLPTKDLSARGIAIPAQQREAQQAEGLMPDGAVIIAAITSCTNTSN 420 Query: 412 PRNVIAAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFA 471 PRNV+AAGLLA+ AN+LGL R+PWVK+S APGSK +LYL+EAGL ++LE+LGFGIVA+A Sbjct: 421 PRNVVAAGLLAKKANQLGLKRQPWVKTSFAPGSKVAKLYLQEAGLLSELEQLGFGIVAYA 480 Query: 472 CTTCNGMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAI 531 CTTCNGMSGALDP IQQEII+RDLY+TAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAI Sbjct: 481 CTTCNGMSGALDPAIQQEIIERDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAI 540 Query: 532 AGTIRFDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVD 591 AGT+RFDIE+D LG A+G+ I L +WPSDEEIDAVV AVKP+QF+ +Y MF ++D Sbjct: 541 AGTMRFDIERDALGHDAQGKPIYLNHLWPSDEEIDAVVGRAVKPEQFKQIYIQMF--KLD 598 Query: 592 RSQSV-SPLYDWRPQSTYIRRPPYWEGALAGERTLSGMRPLAVLGDNITTDHLSPSNAIL 650 +QS SPLYDWRP STYIRRPPYWEGALA RTL MRPLA+LGDNITTDHLSPSNAIL Sbjct: 599 ETQSASSPLYDWRPMSTYIRRPPYWEGALAAPRTLKAMRPLAILGDNITTDHLSPSNAIL 658 Query: 651 LDSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLA 710 SAAGEYL KMG+PEEDFNSYATHRGDHLTAQRATFANPKLFNEMVK+ +G ++QGSLA Sbjct: 659 ASSAAGEYLTKMGVPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKE-NGQIKQGSLA 717 Query: 711 RLEPEGKVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFE 770 R+EPEGKV RMWE IETYM RKQPLI+IAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFE Sbjct: 718 RIEPEGKVTRMWEAIETYMNRKQPLIVIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFE 777 Query: 771 RIHRTNLIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRRPRADLTLVIHRKNGERVEV 830 RIHRTNL+GMGVLPLEFK G NR++ A+DGTE +DV+G+ RP ADL LV+ R+NGE+++V Sbjct: 778 RIHRTNLVGMGVLPLEFKPGVNRHSLALDGTELFDVVGEIRPGADLALVVTRQNGEKLDV 837 Query: 831 PVTCRLDTAEEVSIYEAGGVLQRFAQDFL 859 VTCRLDTA+EV +Y+AGGVLQRFAQDFL Sbjct: 838 AVTCRLDTADEVHVYQAGGVLQRFAQDFL 866 >STM1712 [C] COG1048 Aconitase A Sty Salmonella typhimurium LT2 Length = 891 Score = 723 bits (1865), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/860 (45%), Positives = 540/860 (62%), Gaps = 41/860 (4%) Query: 34 LPYTSRVLAENLVRRCDPATLTDSLRQ-----LIERKRELDFPWFPARVVCHDILGQTAL 88 LP + +VL ENL+R D ++TD Q L + + W PARV+ D G A+ Sbjct: 38 LPKSLKVLLENLLRWQDGESVTDEDIQALAGWLKNAHADREIAWRPARVLMQDFTGVPAV 97 Query: 89 VDLAGLRDAIADMGGDPAKVNPVVPVQLIVDHSLAVECGGDDPQAFVKNRAIEDRRNEDR 148 VDLA +R+A+ +GGD +KVNP+ PV L++DHS+ V+ GDD AF +N +E RN +R Sbjct: 98 VDLAAMREAVKRLGGDTSKVNPLSPVDLVIDHSVTVDHFGDD-DAFEENVRLEMERNHER 156 Query: 149 FHFINWTKLAFENVDVIPPGNGIMHQINLEKMSPVIHA--KDG--VAFPDTLVGTDSHTP 204 + F+ W K AF V+PPG GI HQ+NLE + + + +DG +A+PD+LVGTDSHT Sbjct: 157 YMFLKWGKQAFSRFSVVPPGTGICHQVNLEYLGKAVWSELQDGEWIAYPDSLVGTDSHTT 216 Query: 205 HVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGVELTGRRQPGITATDIVLSLTEFLR 264 ++ LGV+ GVGG+EAE MLG+ M +PD++G +LTG+ + GITATD+VL++T+ LR Sbjct: 217 MINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLR 276 Query: 265 KQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGATAAMFSIDQQTIDYLKLTGREDEQ 324 K VVG ++EFYGDG SL L DRATI+NM+PEYGAT F ID T++Y++L+GR D+ Sbjct: 277 KHGVVGKFVEFYGDGLDSLPLADRATIANMSPEYGATCGFFPIDAITLEYMRLSGRSDDL 336 Query: 325 VKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTVVRTLAGPSNPHKRLPVSELAA----- 379 V+LVETYAK G+W + + + L D+ V +LAGP P R+ + ++ Sbjct: 337 VELVETYAKAQGMWRNPGDEPVFTSTLELDMGDVEASLAGPKRPQDRVALGDVPKAFAAS 396 Query: 380 ------------QGIAGKVENEPGKMPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANR 427 Q + + +P ++PDGAV+IAAITSCTNTSNP ++AAGLLA+ A Sbjct: 397 AELELNTAQRDRQPVDYTMNGQPYQLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKAVT 456 Query: 428 LGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCNGMSGALDPKIQ 487 LGL R+PWVK+SLAPGSK V YL +A LT L++LGF +V + CTTC G SG L I+ Sbjct: 457 LGLKRQPWVKASLAPGSKVVSDYLAQAKLTPYLDELGFNLVGYGCTTCIGNSGPLPEPIE 516 Query: 488 QEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEQDVLGVT 547 I DL AVLSGNRNF+GRIHP K +LASPPLVVAYA+AG + ++ D LG Sbjct: 517 TAIKKGDLTVGAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYALAGNMNINLATDPLGYD 576 Query: 548 AEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVD-RSQSV--SPLYDWRP 604 +G + LKDIWPS +EI A V FR Y +F + +S V S Y W+ Sbjct: 577 RKGDPVYLKDIWPSAQEI-ARAVELVSSDMFRKEYAEVFEGTEEWKSIQVESSDTYGWQS 635 Query: 605 QSTYIRRPPYW---EGALAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAAGEYLAK 661 STYIR P++ + A + + G R LA+LGD++TTDH+SP+ +I DS AG YL Sbjct: 636 DSTYIRLSPFFDEMQAQPAPVKDIHGARILAMLGDSVTTDHISPAGSIKPDSPAGRYLQN 695 Query: 662 MGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPEGKVMRM 721 G+ +DFNSY + RG+H R TFAN ++ NEM+ +G + R P + M + Sbjct: 696 HGVERKDFNSYGSRRGNHEVMMRGTFANIRIRNEMLPGV-----EGGMTRHLPGTEAMSI 750 Query: 722 WETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGMG 781 ++ Y + K PL +IAG +YG GSSRDWAAKG RL G+ ++AE FERIHR+NLIGMG Sbjct: 751 YDAAMLYQQEKTPLAVIAGKEYGSGSSRDWAAKGPRLLGIRVVIAESFERIHRSNLIGMG 810 Query: 782 VLPLEFKAGENRNTYAIDGTETYDV--IGQRRPRADLTLVIHRKNGERVEVPVTCRLDTA 839 +LPLEF G R T + G E D+ + RP A + + + R +G + VP CR+DTA Sbjct: 811 ILPLEFPQGVTRKTLGLTGEEVIDIADLQNLRPGATIPVTLTRSDGSKETVPCRCRIDTA 870 Query: 840 EEVSIYEAGGVLQRFAQDFL 859 E++ Y+ G+L ++ L Sbjct: 871 TELTYYQNDGILHYVIRNML 890 >APE1618 [C] COG1048 Aconitase A Ape Aeropyrum pernix Length = 870 Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust. Identities = 385/860 (44%), Positives = 529/860 (61%), Gaps = 41/860 (4%) Query: 28 PGAWDTLPYTSRVLAENLVRRCDPATLTDSLRQLIERKREL----DFPWFPARVVCHDIL 83 P +++LPY+ RVL EN+VR D + D + + R E D P+ P RVV D Sbjct: 3 PSDFNSLPYSIRVLLENVVRHYDGFVVRDEDVEAVARWSEYAGRKDVPFHPVRVVMQDFT 62 Query: 84 GQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIVDHSLAVECGGDDPQAFVKNRAIEDR 143 G A+VDLA +RDA+ GGDP+KVNP++PV LI+DHS+ V+ G +AF N E Sbjct: 63 GVPAVVDLAAMRDAMKQFGGDPSKVNPLIPVDLIIDHSIQVDYYGT-AEAFRLNLKREYE 121 Query: 144 RNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLEKMSPVI--HAKDGV--AFPDTLVGT 199 RN +R+ + W + AF N V+PPG GI+HQ+NLE ++ V+ ++G A PD+L+GT Sbjct: 122 RNRERYQLLKWAQKAFSNFRVVPPGKGIIHQVNLEYLARVVWLSRRNGTLYAHPDSLLGT 181 Query: 200 DSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGVELTGRRQPGITATDIVLSL 259 DSHT ++ LGV GVGG+EAE V+LG+ +M LP+++GV L G + G+T TD+VL + Sbjct: 182 DSHTTMINGLGVFGWGVGGIEAEAVILGQPYYMLLPEVVGVRLVGELREGVTTTDLVLYI 241 Query: 260 TEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGATAAMFSIDQQTIDYLKLTG 319 TE LRK+ VVG ++E++G+G L++ DRATI+NMAPEYGAT F +D+ T++YL+ TG Sbjct: 242 TEKLRKKNVVGKFVEYFGEGVKKLSVPDRATIANMAPEYGATMGFFPVDEATLEYLRGTG 301 Query: 320 REDEQVKLVETYAKEAGLW-SDTLAKVEYERVLRFDLSTVVRTLAGPSNPHKRLPVSE-- 376 R + V+LVE Y KE GLW S + Y V+ DLS V +++GPS+P R+P+ E Sbjct: 302 RPEWLVQLVERYTKETGLWYSLEDPEPRYSDVVEIDLSDVEPSISGPSHPEDRIPLREAK 361 Query: 377 ----------LAAQG-----IAGKVENEPGKMPDGAVIIAAITSCTNTSNPRNVIAAGLL 421 L +G + K+ +E + DG+V+ AA+TSCTNTSNP +IAA LL Sbjct: 362 ERVRKIIMEYLEKKGRGPAIVELKLGDEEVHLTDGSVVYAALTSCTNTSNPSVMIAAALL 421 Query: 422 ARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCNGMSGA 481 ARNA + GL +PWVK+S APGS+ V Y GL LE LGF I + CT C G SG Sbjct: 422 ARNAVKKGLRTRPWVKTSNAPGSRVVPEYWNRLGLMPYLEALGFHITGYGCTVCIGNSGP 481 Query: 482 LDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEQ 541 L P+I++ I + DL+ VLSGNRNF GRIHP A+ FLASPPLVVAYA+AG + D E+ Sbjct: 482 LRPEIEEAIREHDLWVATVLSGNRNFSGRIHPLARGNFLASPPLVVAYALAGRVDIDFEK 541 Query: 542 DVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQSVSP--- 598 + +G G + L+D+WPS E+ + A+ PQ F Y + + +P Sbjct: 542 EPVGYDPNGNPVYLRDLWPSQREVREAIEKALDPQLFVEKYKDIDKGDKFWEELKAPEGE 601 Query: 599 LYDWRPQSTYIRRPPYWEGA---LAGERTLSGMRPLAVLGDNITTDHLSPSNAILLDSAA 655 LY W P+STYIR+PPY++ R + G R L D +TDH+SP+ I DS A Sbjct: 602 LYSWDPKSTYIRKPPYFDNMPLEPQPPRDIRGARVLVWAPDRTSTDHISPAGRISPDSKA 661 Query: 656 GEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPE 715 G+YL + G+P N+ + RG+H R TF NP+ N++V ++G P Sbjct: 662 GQYLIEQGVPPSQLNTCGSRRGNHEVMMRCTFDNPRFRNKLVPD-----REGGWTIFWPT 716 Query: 716 GKVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRT 775 G+VM +++ Y E PLI++AG YG GSSRDWAAKG L GV+A++AE +ERIHR+ Sbjct: 717 GEVMHVFDAAMKYREMGVPLIVLAGKQYGVGSSRDWAAKGPALLGVKAVIAESYERIHRS 776 Query: 776 NLIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRR---PRADLTLVIHRKNGERVEVPV 832 NL+GMGVLPLEF GEN +DG+E YD+IG P LT+ + +G +E V Sbjct: 777 NLVGMGVLPLEFMPGENAEKLGLDGSEEYDIIGIEEGLSPGKILTVRARKSDGRVIEFKV 836 Query: 833 TCRLDTAEEVSIYEAGGVLQ 852 RLDT EV Y+ GG+LQ Sbjct: 837 KARLDTPIEVEYYKHGGILQ 856 >RP799 [C] COG1048 Aconitase A Rpr Rickettsia prowazekii Length = 878 Score = 716 bits (1847), Expect = 0.0, Method: Compositional matrix adjust. Identities = 385/879 (43%), Positives = 537/879 (61%), Gaps = 42/879 (4%) Query: 2 NTQYRKQL--PGTRLDYFDARAAVEAIRPGAWDTLPYTSRVLAENLVRRCDPATLTDSLR 59 N++Y K+L T +D A I LPY+ RVL EN++R + Sbjct: 6 NSEYIKELVVDNTSYKIYDINKAASDIGL-PLKKLPYSLRVLLENVLRTNGNKENLLVFK 64 Query: 60 QLIERKR---ELDFPWFPARVVCHDILGQTALVDLAGLRDAIADMGGDPAKVNPVVPVQL 116 + ++ K+ E+DF PARV+ D G A+VDLA +RDA+ +G +P K+NP++PV L Sbjct: 65 EWLKTKKSNTEIDF--MPARVLMQDFTGVPAIVDLAAMRDAMQKIGCNPLKINPLIPVDL 122 Query: 117 IVDHSLAVECGGDDPQAFVKNRAIEDRRNEDRFHFINWTKLAFENVDVIPPGNGIMHQIN 176 ++DHS++V+ G+ ++F +N +E +RN +R+ F+ W + AF N V+PPG GI HQ+N Sbjct: 123 VIDHSVSVDSYGNK-ESFDQNVHMEMKRNIERYQFLKWGQQAFNNFKVVPPGTGICHQVN 181 Query: 177 LEKMSPVIHAKDGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPD 236 LE +S V+ DG A+PD+LVGTDSHT V+ L V+ GVGG+EAE+ MLG+ M +P+ Sbjct: 182 LEFLSQVVWHNDGTAYPDSLVGTDSHTTMVNGLSVLGWGVGGIEAESAMLGQPITMIIPE 241 Query: 237 IIGVELTGRRQPGITATDIVLSLTEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAP 296 +IGV+L G+ TATD+VL++TE LR++KVVG ++EF+G+G +LT+ DRATISNM+P Sbjct: 242 VIGVKLIGKLAGMATATDLVLTITEILRRKKVVGKFVEFFGNGLRNLTISDRATISNMSP 301 Query: 297 EYGATAAMFSIDQQTIDYLKLTGREDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLS 356 EYGAT F IDQ+T+ YL++TGRE Q+KLVE YA E LW + EY VL DLS Sbjct: 302 EYGATCGFFPIDQETLKYLEVTGREITQIKLVEKYAIEQNLWYNCEDTQEYTEVLELDLS 361 Query: 357 TVVRTLAGPSNPHKR-------------LPVSELAAQGIAGK--VENEPGKMPDGAVIIA 401 TV +LAGP P R LP LA + I K V N+ + +G V+IA Sbjct: 362 TVYSSLAGPKRPQDRVNLNCVASNFQNELPYFALANKDIDKKYAVANQNYAIGNGDVVIA 421 Query: 402 AITSCTNTSNPRNVIAAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLE 461 AITSCTNTSNP +I A LLA+ A GL KPWVK+SLAPGSK V YL+ +GL L+ Sbjct: 422 AITSCTNTSNPSVMIGAALLAKKALEHGLNVKPWVKTSLAPGSKVVTEYLKLSGLDKYLD 481 Query: 462 KLGFGIVAFACTTCNGMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLA 521 LGF +V + CTTC G SG+L+P+I+ I L +VLSGNRNF+GRI+P K ++LA Sbjct: 482 ALGFNLVGYGCTTCIGNSGSLNPEIENTINKNRLVVASVLSGNRNFEGRINPLTKASYLA 541 Query: 522 SPPLVVAYAIAGTIRFDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNV 581 SP LVVAYA++GT+ D+ T G I LKDIWPS +EID V+ ++ F Sbjct: 542 SPILVVAYALSGTLNIDLTN-----TPIGANIYLKDIWPSQKEIDEVIANSINSSMFIEK 596 Query: 582 YTPMFAARV---DRSQSVSPLYDWRPQSTYIRRPPYWE--GALAGERTLSGMRPLAVLGD 636 Y +F D + Y+W STYI PPY++ G+ + + R LA+ GD Sbjct: 597 YADVFNGTKEWRDLQITTGTNYNWDKNSTYINNPPYFDNIGSEHSIKDIKSARILAIFGD 656 Query: 637 NITTDHLSPSNAILLDSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEM 696 +ITTDH+SP+ +I +S A +YL K + DFNSY + RG+H R TFAN ++ NEM Sbjct: 657 SITTDHISPAGSISKNSPAAKYLIKHHIEPLDFNSYGSRRGNHEVMMRGTFANIRIKNEM 716 Query: 697 VKKADGSVQQGSLARLEPEGKVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGV 756 +G L+ G +++T Y PL+I AG +YG GSSRDWAAKG Sbjct: 717 CNGVEGGFTINQLS-----GVQQTIYDTAMDYKAHDIPLVIFAGKEYGSGSSRDWAAKGP 771 Query: 757 RLAGVEAIVAEGFERIHRTNLIGMGVLPLEFKAGENRNTYAIDGTETYDVIG---QRRPR 813 L G++A++AE FERIHR+NL+GMG+LPL F R +DG+E D+IG +P Sbjct: 772 GLLGIKAVIAESFERIHRSNLVGMGILPLTFTGKNTRLNLKLDGSEIIDLIGLSENIKPY 831 Query: 814 ADLTLVIHRKNGERVEVPVTCRLDTAEEVSIYEAGGVLQ 852 + VI ++ E + + ++ T E++ + G ++Q Sbjct: 832 NLVKCVIKKQTNEISTIDLILQIFTENEINYIKHGSIMQ 870 >MA0250 [C] COG1048 Aconitase A Mac Methanosarcina acetivorans str.C2A Length = 940 Score = 715 bits (1846), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/892 (44%), Positives = 539/892 (60%), Gaps = 71/892 (7%) Query: 34 LPYTSRVLAENLVRRCD------PATLTDSLRQLIERKR-ELDFPWFPARVVCHDILGQT 86 LPY+ R+L E+L+R D A ++L + R E D P+ P+RV+ D G Sbjct: 47 LPYSIRILLESLLRHADTEKHLIAAEDVEALARWSPGNRIERDIPFIPSRVIMQDFTGVP 106 Query: 87 ALVDLAGLRDAIADMGGDPAKVNPVVPVQLIVDHSLAVECGGDDPQAFVKNRAIEDRRNE 146 A+VDLA LR A+ + GDPAK+NPV+P L++DHS+ V+ G A +N E RN Sbjct: 107 AVVDLAALRSAMERLEGDPAKINPVIPADLVIDHSVQVDSYGT-AYALEENEKKEFERNR 165 Query: 147 DRFHFINWTKLAFENVDVIPPGNGIMHQINLEKMSPVIHAKDG----VAFPDTLVGTDSH 202 +R+ + W + AF+N V+PPG GI+HQ+NLE ++P++H K+ AFPDTLVGTDSH Sbjct: 166 ERYIVLRWAQKAFDNFRVVPPGRGIIHQVNLEYLTPLVHLKEKEGELFAFPDTLVGTDSH 225 Query: 203 TPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGVELTGRRQPGITATDIVLSLTEF 262 T ++ +GV+ GVGG+EAE VMLG+ +M +P+++G +L G+ +PG+TATD+VL++T+ Sbjct: 226 TTMINGIGVLGWGVGGIEAEAVMLGQPYYMPVPEVVGFKLYGKLEPGVTATDLVLTITKM 285 Query: 263 LRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGATAAMFSIDQQTIDYLKLTGRED 322 LRKQ VVG ++EFYG G SL+L DRATISNMAPEYGAT +F D +T++YLK TGR D Sbjct: 286 LRKQGVVGKFVEFYGPGLNSLSLPDRATISNMAPEYGATLGIFPPDTETLNYLKRTGRSD 345 Query: 323 EQVKLVETYAKEAGL-WSDTLAKVEYERVLRFDLSTVVRTLAGPSNPHKRL--------- 372 EQV LV+ Y + L +S + + L D+ TV LAGP P +L Sbjct: 346 EQVDLVKKYLEAQDLLYSIHKPEPLFSSNLELDMETVKPCLAGPKRPQDQLFLNEVSENF 405 Query: 373 ---------------------------------PVSELAAQGIAGKVENEPG-KMPDGAV 398 PV E + + +E G ++ G+V Sbjct: 406 RETMRQTFIRKKEGGAELAGDPAYQRWLGEGGAPVEETGIEEVKKVEPHEKGFRVTHGSV 465 Query: 399 IIAAITSCTNTSNPRNVIAAGLLARNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTA 458 +IAAITSCTNTSNP +I AGLLA+ A GL KP+VK+SL+PGS+ YL AGL Sbjct: 466 VIAAITSCTNTSNPSVLIGAGLLAKKAVERGLRVKPFVKTSLSPGSRVATEYLGAAGLLP 525 Query: 459 DLEKLGFGIVAFACTTCNGMSGALDPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQA 518 LE LGF V + CTTC G SG L I +EI ++DL AVLSGNRNF+GRI+P+ K Sbjct: 526 YLEALGFHQVGYGCTTCIGNSGPLPEHIAKEIEEKDLTVAAVLSGNRNFEGRINPHVKAN 585 Query: 519 FLASPPLVVAYAIAGTIRFDIEQDVLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQF 578 +LASPPLVVAYAIAGT+ ++E D L G + ++DIWP +EEI ++KP+ F Sbjct: 586 YLASPPLVVAYAIAGTVNINLETDPLAYDPNGLPVYIRDIWPGNEEIREAEKNSIKPEMF 645 Query: 579 RNVYTPMFAARVDRSQSVSP---LYDWRPQSTYIRRPPYWEG-----ALAGERTLSGMRP 630 + Y+ + + P LY W P STYI+ PPY+ L G+ + R Sbjct: 646 KKEYSGVLEGSKLWKELDVPEGTLYAWSPTSTYIQEPPYFVDFPLTLPLPGD--IQNARV 703 Query: 631 LAVLGDNITTDHLSPSNAILLDSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANP 690 LA+ GD+ITTDH+SP+ I D AG YL G+ ++DFNSY + RG+H R TFAN Sbjct: 704 LALFGDSITTDHISPAGDIPADGPAGRYLISWGVDQKDFNSYGSRRGNHEVMMRGTFANI 763 Query: 691 KLFNEMVKKADG-SVQQGSLARLEPE--GKVMRMWETIETYMERKQPLIIIAGADYGQGS 747 +L N +V + G +V PE G+ + +++ Y E PLI++AG +YG GS Sbjct: 764 RLRNRLVSREGGWTVSHLKGEDFPPEACGEGIPIYDAALLYAENDVPLIVLAGKEYGTGS 823 Query: 748 SRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGMGVLPLEFKAGENRNTYAIDGTETYDVI 807 SRDWAAKG L GV+A++AE FERIHR+NL+GMGVLPL+F GEN +T + G E+YD++ Sbjct: 824 SRDWAAKGTFLLGVKAVIAESFERIHRSNLVGMGVLPLQFNVGENADTLGLTGKESYDIL 883 Query: 808 G--QRRPRADLTLVIHRKNGERVEVPVTCRLDTAEEVSIYEAGGVLQRFAQD 857 G Q P +LT+ NG E VT RLD+A E+ Y GG+L +F +D Sbjct: 884 GIEQMEPHGELTVRAKDDNGGETEFRVTLRLDSAVEIEYYRNGGILHKFLRD 935 >YPO2221 [C] COG1048 Aconitase A Ype Yersinia pestis Length = 890 Score = 712 bits (1837), Expect = 0.0, Method: Compositional matrix adjust. Identities = 385/866 (44%), Positives = 535/866 (61%), Gaps = 43/866 (4%) Query: 29 GAWDTLPYTSRVLAENLVRRCDPATLTDS-LRQLIERKR----ELDFPWFPARVVCHDIL 83 G + LP + +VL ENL+R D + ++ L+ ++ ++ + + + PARV+ D Sbjct: 33 GDINRLPKSLKVLLENLLRHLDGVQVQEADLKAIVAWQQTGHADREIAYRPARVLMQDFT 92 Query: 84 GQTALVDLAGLRDAIADMGGDPAKVNPVVPVQLIVDHSLAVECGGDDPQAFVKNRAIEDR 143 G A+VDLA +R+A+ +GGD A+VNP+ PV L++DHS+ V+ GD AF +N +E Sbjct: 93 GVPAVVDLAAMREAVQRLGGDVAQVNPLSPVDLVIDHSVTVDEFGDK-SAFGENVRLEME 151 Query: 144 RNEDRFHFINWTKLAFENVDVIPPGNGIMHQINLEKMSPVI-HAKDG---VAFPDTLVGT 199 RN +R+ F+ W + AF V+PPG GI HQ+NLE + + H + G VA+PDTLVGT Sbjct: 152 RNHERYIFLRWGQKAFSRFRVVPPGTGICHQVNLEYLGQTVWHEQQGDKQVAYPDTLVGT 211 Query: 200 DSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIIGVELTGRRQPGITATDIVLSL 259 DSHT ++ LG++ GVGG+EAE MLG+ M +PD++G ++TG+ + GITATD+VL++ Sbjct: 212 DSHTTMINGLGILGWGVGGIEAEAAMLGQPISMLIPDVVGFKMTGKMREGITATDLVLTV 271 Query: 260 TEFLRKQKVVGAYLEFYGDGAASLTLGDRATISNMAPEYGATAAMFSIDQQTIDYLKLTG 319 T+ LRK VVG ++EFYGDG A L L DRATI+NM+PE+GAT F +D+ T++Y++L+G Sbjct: 272 TQMLRKHGVVGKFVEFYGDGLADLPLADRATIANMSPEFGATCGFFPVDEVTLNYMRLSG 331 Query: 320 REDEQVKLVETYAKEAGLWSDTLAKVEYERVLRFDLSTVVRTLAGPSNPHKRLPVSEL-- 377 R +EQ+ LVETY+K GLW + + L DLS+V +LAGP P R+ + ++ Sbjct: 332 RSNEQIALVETYSKAQGLWRYPGDEPVFTSQLSLDLSSVEPSLAGPKRPQDRVALPKVPS 391 Query: 378 ---------------AAQGIAGKVENEPGKMPDGAVIIAAITSCTNTSNPRNVIAAGLLA 422 A +A + + ++ GAV+IAAITSCTNTSNP ++AAGLLA Sbjct: 392 AFKAFEELEFNNKRDKADLVAFSLNGKTHELASGAVVIAAITSCTNTSNPSVLMAAGLLA 451 Query: 423 RNANRLGLARKPWVKSSLAPGSKAVELYLEEAGLTADLEKLGFGIVAFACTTCNGMSGAL 482 + A GL KPWVK+SLAPGSK V YL AGLT L+ LGF +V + CTTC G SG L Sbjct: 452 KKATEKGLKTKPWVKTSLAPGSKVVTEYLNSAGLTRYLDNLGFNLVGYGCTTCIGNSGPL 511 Query: 483 DPKIQQEIIDRDLYSTAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEQD 542 I+ I DL +AVLSGNRNF+GRIHP K +LASPPLVVAYA+AG + D+ QD Sbjct: 512 PEPIENAIKAGDLTVSAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYALAGNMNIDLTQD 571 Query: 543 VLGVTAEGREIRLKDIWPSDEEIDAVVTAAVKPQQFRNVYTPMFAARVDRSQSV----SP 598 LG G+ + LKDIWP+ EI A VK + FR Y +F + Q++ +P Sbjct: 572 ALGHDPSGKPVFLKDIWPTGLEI-AKAVEEVKTEMFRKEYAEVFNGD-ENWQAIQIESTP 629 Query: 599 LYDWRPQSTYIRRPPYWEGALAGE---RTLSGMRPLAVLGDNITTDHLSPSNAILLDSAA 655 Y W+ STYIR PP++ A + + R LA+L D++TTDH+SP+ I LDS A Sbjct: 630 TYAWQKDSTYIRLPPFFTDMKAVPDPVQDIHDARILAILADSVTTDHISPAGNIKLDSPA 689 Query: 656 GEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKKADGSVQQGSLARLEPE 715 G YL G+ ++FNSY + RG+H R TFAN ++ NEMV +G + R P Sbjct: 690 GRYLRDHGVEIKEFNSYGSRRGNHKVMMRGTFANIRIRNEMVPGIEGGI-----TRHIPS 744 Query: 716 GKVMRMWETIETYMERKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRT 775 M +++ Y + PL +IAG +YG GSSRDWAAKG RL GV ++ E FERIHR+ Sbjct: 745 QNEMPIYDAAMRYQQENVPLAVIAGKEYGSGSSRDWAAKGPRLLGVRVVITESFERIHRS 804 Query: 776 NLIGMGVLPLEFKAGENRNTYAIDGTETYDVIGQRR--PRADLTLVIHRKNGERVEVPVT 833 NLIGMG+LPLEF G +R T + G E+ V G + P + + I +G + V Sbjct: 805 NLIGMGILPLEFPQGVDRKTLRLTGDESISVSGLQNLAPGQMVPVTITYADGHQQVVNTR 864 Query: 834 CRLDTAEEVSIYEAGGVLQRFAQDFL 859 CR+DT E+ +E GG+L + L Sbjct: 865 CRIDTGNELIYFENGGILHYVIRKML 890