BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0227.p (260 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0518 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 289 3e-78 NMB0697 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 272 5e-73 NMA0902 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 271 9e-73 VC0443 [J] COG0030 Dimethyladenosine transferase (rRNA methylati... 258 1e-68 ksgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation... 255 6e-68 ZksgA [J] COG0030 Dimethyladenosine transferase (rRNA methylatio... 255 7e-68 ECs0056 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 255 7e-68 PA0592 [J] COG0030 Dimethyladenosine transferase (rRNA methylati... 254 2e-67 STM0090 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 251 9e-67 YPO0492 [J] COG0030 Dimethyladenosine transferase (rRNA methylat... 249 4e-66 >RSc0518 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Rso Ralstonia solanacearum Length = 281 Score = 289 bits (740), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 156/261 (59%), Positives = 187/261 (71%), Gaps = 6/261 (2%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H RKRFGQNFL D+ V+H I+ +I P DD +VEIGPGL A+T L+E + L VVELD Sbjct: 12 HQARKRFGQNFLVDDGVIHAIVAAIDPQPDDVLVEIGPGLGALTVPLMERVPTLQVVELD 71 Query: 63 RDLVERLKKRFDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAEI 122 RDLV RL++RF +L VH+ DAL FDF T+ VP GR LR+VGNLPYNISSPLLFHL+ Sbjct: 72 RDLVARLQRRF-GDKLIVHAGDALAFDFGTLHVP-GRSLRIVGNLPYNISSPLLFHLSAF 129 Query: 123 APQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVDS 182 A +V+DQHFMLQKEVV+RMVA PGSKA+ RLSVMLQ RY+MEL+ VPP +F+PPPKVDS Sbjct: 130 ADRVRDQHFMLQKEVVDRMVAAPGSKAFSRLSVMLQVRYYMELVLEVPPGSFNPPPKVDS 189 Query: 183 AIVRMIPL---AQPLA-CQQALLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQA 238 A+VRMIP P A L VVT AFSQRRKV+RN + L + +G D Sbjct: 190 AVVRMIPWPADKSPYAPVDMRALGTVVTLAFSQRRKVLRNTLGSLREVIDFDALGFDLGR 249 Query: 239 RPEAVPMEQFVALANLLAARQ 259 R E VP+ FVA+AN L A + Sbjct: 250 RAEEVPVADFVAVANALPAER 270 >NMB0697 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Nme Neisseria meningitidis MC58 Length = 259 Score = 272 bits (696), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 141/259 (54%), Positives = 181/259 (69%), Gaps = 6/259 (2%) Query: 2 KHIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVEL 61 +H RKRFGQNFL D ++ DI+ ++ P ADD ++EIGPGLAA+T L + L LHVVE+ Sbjct: 3 EHKARKRFGQNFLQDTRIISDIVNAVRPQADDVVIEIGPGLAAITEPLAKKLNRLHVVEI 62 Query: 62 DRDLVERLKKRFDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 DRD+V RLK A +L +H D L+FDF+ I G+K ++VGNLPYNIS+PLLF LAE Sbjct: 63 DRDIVCRLKTLPFADKLVIHEGDVLQFDFNGIA---GKK-KIVGNLPYNISTPLLFKLAE 118 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 +A V D HFMLQKEVVERMVA P S YGRL VMLQ+ + ME+L VPP +FDP PKVD Sbjct: 119 VADDVVDMHFMLQKEVVERMVAAPKSNDYGRLGVMLQYFFDMEMLIDVPPESFDPAPKVD 178 Query: 182 SAIVRMIPLAQPLACQQAL--LEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VRMIP+ + ++V AF QRRK IRN + L +D+L+ VGI+PQ R Sbjct: 179 SAVVRMIPVKHRIGKADDFEHFAKLVKLAFHQRRKTIRNNLKELAGDDDLQAVGINPQDR 238 Query: 240 PEAVPMEQFVALANLLAAR 258 E + E++VAL+N LA + Sbjct: 239 AEHIAPEKYVALSNYLAGK 257 >NMA0902 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) NmA Neisseria meningitidis Z2491 Length = 259 Score = 271 bits (693), Expect = 9e-73, Method: Compositional matrix adjust. Identities = 140/259 (54%), Positives = 181/259 (69%), Gaps = 6/259 (2%) Query: 2 KHIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVEL 61 +H RKRFGQNFL D ++ DI+ ++ P ADD ++EIGPGLAA+T L + L LHVVE+ Sbjct: 3 EHKARKRFGQNFLQDTRIISDIVNAVRPQADDVVIEIGPGLAAITEPLAKKLNRLHVVEI 62 Query: 62 DRDLVERLKKRFDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 DRD+V RLK A +L +H D L+FDF+ I G+K ++VGNLPYNIS+PLLF LAE Sbjct: 63 DRDIVCRLKTLPFADKLVIHEGDVLQFDFNGIA---GKK-KIVGNLPYNISTPLLFKLAE 118 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 +A V D HFMLQKEVV+RMVA P S YGRL VMLQ+ + ME+L VPP +FDP PKVD Sbjct: 119 VADDVVDMHFMLQKEVVDRMVAAPKSNDYGRLGVMLQYFFDMEMLIDVPPESFDPAPKVD 178 Query: 182 SAIVRMIPLAQPLACQQAL--LEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VRMIP+ + ++V AF QRRK IRN + L +D+L+ VGI+PQ R Sbjct: 179 SAVVRMIPVKHRIGKADDFEHFAKLVKLAFHQRRKTIRNNLKELAGDDDLQAVGINPQDR 238 Query: 240 PEAVPMEQFVALANLLAAR 258 E + E++VAL+N LA + Sbjct: 239 AEHIAPEKYVALSNYLAGK 257 >VC0443 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Vch Vibrio cholerae Length = 282 Score = 258 bits (659), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 133/261 (50%), Positives = 176/261 (67%), Gaps = 6/261 (2%) Query: 1 MKHIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVE 60 + H RKRFGQNFL D ++ I+++I P +VEIGPGL A+T + + V+E Sbjct: 18 LGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIE 77 Query: 61 LDRDLVERLKKRFD-AARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHL 119 LDRDL ERL+ + A++LT+H DA++FDF + P+ KLRV GNLPYNIS+PL+FHL Sbjct: 78 LDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNN-KLRVFGNLPYNISTPLMFHL 136 Query: 120 AEIAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPK 179 E +QD HFMLQKEVV R+ A PG+KAYGRL+VM Q+ + + VPP+AF PPPK Sbjct: 137 FEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPSAFVPPPK 196 Query: 180 VDSAIVRMIP---LAQPLACQQALLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDP 236 VDSA+VR++P L P A L++VV + F+QRRK +RNC GL + L +GI+P Sbjct: 197 VDSAVVRLVPYEDLPHP-ATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINP 255 Query: 237 QARPEAVPMEQFVALANLLAA 257 RPE + + QFVALAN L A Sbjct: 256 GMRPENLTLAQFVALANWLDA 276 >ksgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Eco Escherichia coli K12 Length = 273 Score = 255 bits (652), Expect = 6e-68, Method: Compositional matrix adjust. Identities = 132/257 (51%), Positives = 174/257 (67%), Gaps = 3/257 (1%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H+ RKRFGQNFL D+ V+ I+++I P AMVEIGPGLAA+T + E L L V+ELD Sbjct: 9 HLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELD 68 Query: 63 RDLVERLKKR-FDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 RDL RL+ F +LT++ DA+ F+F + G+ LRV GNLPYNIS+PL+FHL Sbjct: 69 RDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFS 128 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 + D HFMLQKEVV R+VA P SKAYGRLSVM Q+ ++ + VPP+AF PPPKVD Sbjct: 129 YTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVD 188 Query: 182 SAIVRMIPLAQ-PLACQQA-LLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VR++P A P + +L ++ T+AF+QRRK IRN + LFS + L +GIDP R Sbjct: 189 SAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMR 248 Query: 240 PEAVPMEQFVALANLLA 256 E + + Q+ +AN LA Sbjct: 249 AENISVAQYCQMANYLA 265 >ZksgA [J] COG0030 Dimethyladenosine transferase (rRNA methylation) EcZ Escherichia coli O157:H7 EDL933 Length = 273 Score = 255 bits (651), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 132/257 (51%), Positives = 174/257 (67%), Gaps = 3/257 (1%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H+ RKRFGQNFL D+ V+ I+++I P AMVEIGPGLAA+T + E L L V+ELD Sbjct: 9 HLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELD 68 Query: 63 RDLVERLKKR-FDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 RDL RL+ F +LT++ DA+ F+F + G+ LRV GNLPYNIS+PL+FHL Sbjct: 69 RDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFS 128 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 + D HFMLQKEVV R+VA P SKAYGRLSVM Q+ ++ + VPP+AF PPPKVD Sbjct: 129 YTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVD 188 Query: 182 SAIVRMIPLAQ-PLACQQA-LLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VR++P A P + +L ++ T+AF+QRRK IRN + LFS + L +GIDP R Sbjct: 189 SAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMR 248 Query: 240 PEAVPMEQFVALANLLA 256 E + + Q+ +AN LA Sbjct: 249 AENISVAQYCQMANYLA 265 >ECs0056 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Ecs Escherichia coli O157:H7 Length = 273 Score = 255 bits (651), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 132/257 (51%), Positives = 174/257 (67%), Gaps = 3/257 (1%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H+ RKRFGQNFL D+ V+ I+++I P AMVEIGPGLAA+T + E L L V+ELD Sbjct: 9 HLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELD 68 Query: 63 RDLVERLKKR-FDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 RDL RL+ F +LT++ DA+ F+F + G+ LRV GNLPYNIS+PL+FHL Sbjct: 69 RDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFS 128 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 + D HFMLQKEVV R+VA P SKAYGRLSVM Q+ ++ + VPP+AF PPPKVD Sbjct: 129 YTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVD 188 Query: 182 SAIVRMIPLAQ-PLACQQA-LLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VR++P A P + +L ++ T+AF+QRRK IRN + LFS + L +GIDP R Sbjct: 189 SAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMR 248 Query: 240 PEAVPMEQFVALANLLA 256 E + + Q+ +AN LA Sbjct: 249 AENISVAQYCQMANYLA 265 >PA0592 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Pae Pseudomonas aeruginosa Length = 268 Score = 254 bits (648), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 136/258 (52%), Positives = 177/258 (68%), Gaps = 4/258 (1%) Query: 2 KHIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVEL 61 +H RKRFGQNFL D V+H I+ +I ++EIGPG A+T LL L V+EL Sbjct: 6 QHRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIEL 65 Query: 62 DRDLVERLKKRFD-AARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLA 120 D+DL+ LK +F +R ++H DALKFDF+++ V G KLRVVGNLPYNIS+PL+FHL Sbjct: 66 DQDLIPLLKLKFGLESRFSLHQGDALKFDFASL-VESGEKLRVVGNLPYNISTPLIFHLL 124 Query: 121 EIAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKV 180 E AP ++D HFMLQKEVVER+ A PG +GRLS+M+Q+ +E LF V P AF+PPPKV Sbjct: 125 EHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNPPPKV 184 Query: 181 DSAIVRMIPLAQP--LACQQALLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQA 238 DSAIVR+ P A+P A LLE+VV +AF+QRRK +RN + L S +++ +DP Sbjct: 185 DSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLSVEDIEAAEVDPTL 244 Query: 239 RPEAVPMEQFVALANLLA 256 RPE + + FV LAN LA Sbjct: 245 RPEQLDLAAFVRLANQLA 262 >STM0090 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Sty Salmonella typhimurium LT2 Length = 273 Score = 251 bits (642), Expect = 9e-67, Method: Compositional matrix adjust. Identities = 129/257 (50%), Positives = 171/257 (66%), Gaps = 3/257 (1%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H+ RKRFGQNFL D V+ I+++I P AMVEIGPGLAA+T + E L L V+ELD Sbjct: 9 HLARKRFGQNFLNDRFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDKLTVIELD 68 Query: 63 RDLVERLKKR-FDAARLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 RDL RL+ F +LT++ DA+ +F + G+ LRV GNLPYNIS+PL+FHL Sbjct: 69 RDLAARLQTHPFLGPKLTIYQQDAMTMNFGELSAQLGQPLRVFGNLPYNISTPLMFHLFS 128 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 + D HFMLQKEVV R+VA P SK YGRLSVM Q+ + + VPP+AF PPPKVD Sbjct: 129 YTDAIADMHFMLQKEVVNRLVAGPNSKEYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVD 188 Query: 182 SAIVRMIPLAQ-PLACQQA-LLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQAR 239 SA+VR++P A P + +L ++ T+AF+QRRK IRN + LFS + L ++GIDP R Sbjct: 189 SAVVRLVPHATMPYPVKDIRVLSRITTEAFNQRRKTIRNSLGNLFSVETLTEMGIDPAMR 248 Query: 240 PEAVPMEQFVALANLLA 256 E + + Q+ +AN L+ Sbjct: 249 AENISVAQYCQMANYLS 265 >YPO0492 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) Ype Yersinia pestis Length = 272 Score = 249 bits (636), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 127/260 (48%), Positives = 176/260 (67%), Gaps = 5/260 (1%) Query: 3 HIPRKRFGQNFLTDEMVLHDIITSIAPAADDAMVEIGPGLAAMTALLLEGLRHLHVVELD 62 H RKRFGQNFL D+ V+ I+++I P +A+VEIGPGL A+T + + H+ V+ELD Sbjct: 9 HFARKRFGQNFLNDQFVIDSIVSAIHPVPGEAVVEIGPGLGALTEPVAARMDHMTVIELD 68 Query: 63 RDLVERLKKRFDAA-RLTVHSADALKFDFSTIPVPDGRKLRVVGNLPYNISSPLLFHLAE 121 RDL RL +LT+H DA+K +FS + G+ LRV GNLPYNIS+PL+FHL Sbjct: 69 RDLAARLASHPQLKDKLTIHQQDAMKVNFSELSEQAGQPLRVFGNLPYNISTPLMFHLFS 128 Query: 122 IAPQVQDQHFMLQKEVVERMVAEPGSKAYGRLSVMLQWRYHMELLFVVPPTAFDPPPKVD 181 ++D HFMLQKEVV R+VA P SK YGRL+VM Q+ ++ + VPPTAF P PKVD Sbjct: 129 YTDAIRDMHFMLQKEVVNRLVAGPNSKTYGRLTVMAQYYCNVIPVLEVPPTAFTPAPKVD 188 Query: 182 SAIVRMIPLAQ---PLACQQALLEQVVTKAFSQRRKVIRNCVAGLFSEDELRQVGIDPQA 238 SA+VR+IP Q P+ + +L ++ T+AF+QRRK +RN + LF+ ++L ++GIDP Sbjct: 189 SAVVRLIPHVQMPHPVGDVR-MLSRITTQAFNQRRKTVRNSLGDLFTSEQLIELGIDPIL 247 Query: 239 RPEAVPMEQFVALANLLAAR 258 R E + + Q+ LAN L+A+ Sbjct: 248 RAENISVAQYCKLANWLSAQ 267