BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0134.p (275 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2630 [H] COG0413 Ketopantoate hydroxymethyltransferase Rso Ra... 376 e-104 NMA1088 [H] COG0413 Ketopantoate hydroxymethyltransferase NmA Ne... 305 6e-83 NMB0870 [H] COG0413 Ketopantoate hydroxymethyltransferase Nme Ne... 300 3e-81 panB [H] COG0413 Ketopantoate hydroxymethyltransferase Eco Esche... 297 2e-80 ZpanB [H] COG0413 Ketopantoate hydroxymethyltransferase EcZ Esch... 296 3e-80 ECs0138 [H] COG0413 Ketopantoate hydroxymethyltransferase Ecs Es... 296 3e-80 PA4729 [H] COG0413 Ketopantoate hydroxymethyltransferase Pae Pse... 295 1e-79 STM0182 [H] COG0413 Ketopantoate hydroxymethyltransferase Sty Sa... 288 9e-78 YPO3401 [H] COG0413 Ketopantoate hydroxymethyltransferase Ype Ye... 284 1e-76 VC0592 [H] COG0413 Ketopantoate hydroxymethyltransferase Vch Vib... 276 4e-74 >RSc2630 [H] COG0413 Ketopantoate hydroxymethyltransferase Rso Ralstonia solanacearum Length = 274 Score = 376 bits (966), Expect = e-104, Method: Compositional matrix adjust. Identities = 182/275 (66%), Positives = 217/275 (78%), Gaps = 3/275 (1%) Query: 1 MAGYLQESGAARAKPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLG 60 M+ YLQES K VT +LQ MRA G++I+MLT YDASFA LMER+G++ VL+GDSLG Sbjct: 1 MSSYLQES---TRKAVTVTSLQGMRAAGERIAMLTAYDASFAALMERSGVDVVLVGDSLG 57 Query: 61 MVCQGHDSTLPVTIQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGA 120 V QG +TLPVT+ + YHT VARGT L+++DLPFGTY T E+AF +A +MQAGA Sbjct: 58 NVVQGQKTTLPVTLDHIVYHTECVARGTTKALLMSDLPFGTYGTPEQAFHSAVRVMQAGA 117 Query: 121 QMIKLEGGVWLADTIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADAL 180 QM+KLEGG WLA T++FL ER IPVCAHIGLTPQSVH GGFKVQG+ + A QL ADAL Sbjct: 118 QMVKLEGGEWLAPTLRFLVERSIPVCAHIGLTPQSVHAFGGFKVQGRGDEAAAQLKADAL 177 Query: 181 AVQQAGASLVVIEAVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSR 240 AVQ AGA +V++EA+PATL EVT L++PTIGIGAGP+CSGQVLVMHDMLGVFPGH+ + Sbjct: 178 AVQDAGAQMVLMEAIPATLAGEVTRLLAVPTIGIGAGPECSGQVLVMHDMLGVFPGHRPK 237 Query: 241 FVRNFMDGASGIEEAVRRYVAAVKDGSFPAQEHCF 275 FVRNFMDG + I+ AV YV AVKDG+FP EH F Sbjct: 238 FVRNFMDGLTTIDAAVTAYVTAVKDGTFPGPEHSF 272 >NMA1088 [H] COG0413 Ketopantoate hydroxymethyltransferase NmA Neisseria meningitidis Z2491 Length = 263 Score = 305 bits (782), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 157/261 (60%), Positives = 199/261 (76%), Gaps = 2/261 (0%) Query: 16 VTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVTIQ 75 +T +TLQ M+A G+KI+MLT Y++SFA LM+ AG++ +L+GDSLGM QG STLPV+++ Sbjct: 2 ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVDVLLVGDSLGMAVQGRQSTLPVSLR 61 Query: 76 DVAYHTAAVARGTRTMLIIADLPFGTYP-TREEAFRNAALLMQAGAQMIKLEGGVWLADT 134 D+ YHT VARG + +I++DLPFG Y ++E+AF AA LM AGA M+KLEGGVW+A+T Sbjct: 62 DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121 Query: 135 IKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIEA 194 +FL RGIPVCAHIGLTPQSV GG+KVQG+ A L DA A AGA++V++E Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGK-AQALLNDAKAHDDAGAAVVLMEC 180 Query: 195 VPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIEE 254 VPA L K+VT+ +S PTIGIGAG DC GQVLVMHDMLG+FPG ++FV+NFM G S I+ Sbjct: 181 VPAELAKKVTESVSCPTIGIGAGVDCDGQVLVMHDMLGIFPGKTAKFVKNFMQGQSSIQA 240 Query: 255 AVRRYVAAVKDGSFPAQEHCF 275 AVR YVA VK +FPA EH F Sbjct: 241 AVRAYVAEVKAKTFPAAEHIF 261 >NMB0870 [H] COG0413 Ketopantoate hydroxymethyltransferase Nme Neisseria meningitidis MC58 Length = 263 Score = 300 bits (768), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 155/261 (59%), Positives = 197/261 (75%), Gaps = 2/261 (0%) Query: 16 VTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVTIQ 75 +T +TLQ M+A G+KI+MLT Y++SFA LM+ AG+E +L+GDSLGM QG STLPV+++ Sbjct: 2 ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLR 61 Query: 76 DVAYHTAAVARGTRTMLIIADLPFGTYP-TREEAFRNAALLMQAGAQMIKLEGGVWLADT 134 D+ YHT VARG + +I++DLPFG Y ++E+AF AA LM AGA M+KLEGGVW+A+T Sbjct: 62 DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121 Query: 135 IKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIEA 194 +FL RGIPVCAHIGLTPQSV GG+KVQG+ A L DA A AGA++V++E Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGK-AQALLNDAKAHDDAGAAVVLMEC 180 Query: 195 VPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIEE 254 V A L K+VT+ +S PTIGIGAG DC GQVLVMHDMLG+FPG ++FV+NFM G ++ Sbjct: 181 VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA 240 Query: 255 AVRRYVAAVKDGSFPAQEHCF 275 AVR YVA VK +FPA EH F Sbjct: 241 AVRAYVAEVKAKTFPAAEHIF 261 >panB [H] COG0413 Ketopantoate hydroxymethyltransferase Eco Escherichia coli K12 Length = 264 Score = 297 bits (760), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 139/262 (53%), Positives = 182/262 (69%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 KP T LQ + + + + +T YD SFA L GL +L+GDSLGM QGHDSTLPVT Sbjct: 2 KPTTISLLQKYKQEKKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVT 61 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 + D+AYHTAAV RG L++ADLPF Y T E+AF NAA +M+AGA M+K+EGG WL + Sbjct: 62 VADIAYHTAAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVE 121 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 T++ LTER +PVC H+GLTPQSV+ GG+KVQG+ + QL +DALA++ AGA L+V+E Sbjct: 122 TVQMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLE 181 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIE 253 VP L K +T+ L+IP IGIGAG GQ+LVMHD G+ GH +F +NF+ I Sbjct: 182 CVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIR 241 Query: 254 EAVRRYVAAVKDGSFPAQEHCF 275 AVR+Y+A V+ G +P +EH F Sbjct: 242 AAVRQYMAEVESGVYPGEEHSF 263 >ZpanB [H] COG0413 Ketopantoate hydroxymethyltransferase EcZ Escherichia coli O157:H7 EDL933 Length = 264 Score = 296 bits (759), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 137/262 (52%), Positives = 184/262 (70%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 KP T +LQ + + + + +T YD SFA L GL +L+GDSLGM QGH+STLPVT Sbjct: 2 KPTTIASLQKCKQEKKRFATITAYDYSFAKLFAEEGLNVMLVGDSLGMTVQGHESTLPVT 61 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 ++D+AYHT AV RG L++ADLPF Y T E+AF NAA +M+AGA M+K+EGG WL + Sbjct: 62 VEDIAYHTTAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVE 121 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 T+K LTER +PVC H+GLTPQSV+ GG+KVQG+ + + +L +DALA++ AGA L+V+E Sbjct: 122 TVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEASDRLLSDALALEAAGAQLLVLE 181 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIE 253 VP L K +T+ L+IP IGIGAG GQ+LVMHD G+ GH +F +NF+ I Sbjct: 182 CVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIR 241 Query: 254 EAVRRYVAAVKDGSFPAQEHCF 275 AVR+Y+A V+ G +P +EH F Sbjct: 242 AAVRQYMAEVESGVYPGEEHSF 263 >ECs0138 [H] COG0413 Ketopantoate hydroxymethyltransferase Ecs Escherichia coli O157:H7 Length = 264 Score = 296 bits (759), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 137/262 (52%), Positives = 184/262 (70%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 KP T +LQ + + + + +T YD SFA L GL +L+GDSLGM QGH+STLPVT Sbjct: 2 KPTTIASLQKCKQEKKRFATITAYDYSFAKLFAEEGLNVMLVGDSLGMTVQGHESTLPVT 61 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 ++D+AYHT AV RG L++ADLPF Y T E+AF NAA +M+AGA M+K+EGG WL + Sbjct: 62 VEDIAYHTTAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVE 121 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 T+K LTER +PVC H+GLTPQSV+ GG+KVQG+ + + +L +DALA++ AGA L+V+E Sbjct: 122 TVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEASDRLLSDALALEAAGAQLLVLE 181 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIE 253 VP L K +T+ L+IP IGIGAG GQ+LVMHD G+ GH +F +NF+ I Sbjct: 182 CVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIR 241 Query: 254 EAVRRYVAAVKDGSFPAQEHCF 275 AVR+Y+A V+ G +P +EH F Sbjct: 242 AAVRQYMAEVESGVYPGEEHSF 263 >PA4729 [H] COG0413 Ketopantoate hydroxymethyltransferase Pae Pseudomonas aeruginosa Length = 266 Score = 295 bits (754), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 144/261 (55%), Positives = 189/261 (72%), Gaps = 1/261 (0%) Query: 16 VTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVTIQ 75 VT TLQ ++ G+KI+MLTCYDA+FA +AG++ +L+GDSLGMV QGHDSTLPV+ + Sbjct: 4 VTLTTLQGLKQSGEKIAMLTCYDATFAHTASQAGVDVLLVGDSLGMVLQGHDSTLPVSNE 63 Query: 76 DVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLADTI 135 ++AYHTA V RG + LI+ DL F + + + +A LMQAGA M+KLEGGVWLA+ I Sbjct: 64 EMAYHTACVKRGNKGSLIVTDLAFESSHSVAQTLADAVRLMQAGAHMVKLEGGVWLAEPI 123 Query: 136 KFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIEAV 195 L + G+PVCAH+GLTPQ+V+ GGFKVQG+ A QL ADA+A++QAGA+++++E V Sbjct: 124 ARLAQMGVPVCAHLGLTPQAVNLFGGFKVQGRQETQARQLRADAIALEQAGAAMLLLECV 183 Query: 196 PATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGV-FPGHKSRFVRNFMDGASGIEE 254 P+ L +E+T + IP IGIGAG GQVLVMHDMLG+ G +FV++FM G I Sbjct: 184 PSVLAEEITQAVKIPVIGIGAGAATDGQVLVMHDMLGLSLTGRSPKFVKDFMQGQESIPA 243 Query: 255 AVRRYVAAVKDGSFPAQEHCF 275 A+ YV AVKD SFPA EH F Sbjct: 244 AIAAYVRAVKDVSFPAAEHGF 264 >STM0182 [H] COG0413 Ketopantoate hydroxymethyltransferase Sty Salmonella typhimurium LT2 Length = 263 Score = 288 bits (737), Expect = 9e-78, Method: Compositional matrix adjust. Identities = 137/262 (52%), Positives = 181/262 (69%), Gaps = 1/262 (0%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 KP T LQ + + + + +T YD SFA L G+ +L+GDSLGM QGHDSTLPVT Sbjct: 2 KPTTISLLQKCKQEKKRFATITAYDYSFAKLFADEGINVMLVGDSLGMTIQGHDSTLPVT 61 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 ++D+AYHT AV RG L+++DLPF Y T E+A NAA++M+AGA M+K+EGG WL D Sbjct: 62 VEDIAYHTRAVRRGAPNCLLLSDLPFMAYATPEQACENAAIVMRAGANMVKIEGGAWLVD 121 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 T+K LTER +PVC H+GLTPQSV+ GG+K+QG+ D L DALA++ AGA L+V+E Sbjct: 122 TVKMLTERAVPVCGHLGLTPQSVNIFGGYKIQGR-GDAGQVLLDDALALEAAGAQLLVLE 180 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIE 253 VP L K VT+ LSIP IGIGAG GQ+LVMHD G+ GH +F +NF+ A + Sbjct: 181 CVPVELAKRVTEALSIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDMR 240 Query: 254 EAVRRYVAAVKDGSFPAQEHCF 275 AV++Y+A V+ G +P +EH F Sbjct: 241 AAVQQYMAEVESGVYPGEEHSF 262 >YPO3401 [H] COG0413 Ketopantoate hydroxymethyltransferase Ype Yersinia pestis Length = 266 Score = 284 bits (727), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 139/263 (52%), Positives = 183/263 (69%), Gaps = 1/263 (0%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 K T L+ + + K + LT YDASFA L G++ +L+GDSLGM QG DSTLPVT Sbjct: 3 KTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLPVT 62 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 + D+AYHT AV RG L++AD+PF +Y T E AF +AA LM+AGA M+KLEGG WL D Sbjct: 63 VADMAYHTRAVRRGAPHCLLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWLCD 122 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 TI+ L ER +PVC H+GLTPQSV+ GG+KVQG+ A QL DA+A++QAGA L+V+E Sbjct: 123 TIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVAANQLLQDAIALEQAGAQLLVLE 182 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASG-I 252 VP L + VT+ L+IP IGIGAG GQ+LVMHD LG+ GH +F +NF+ ++G I Sbjct: 183 CVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAGDI 242 Query: 253 EEAVRRYVAAVKDGSFPAQEHCF 275 A++ Y+ V+ G +PA+EH F Sbjct: 243 RAAIKLYIEEVEGGIYPAEEHTF 265 >VC0592 [H] COG0413 Ketopantoate hydroxymethyltransferase Vch Vibrio cholerae Length = 264 Score = 276 bits (706), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 130/260 (50%), Positives = 176/260 (67%) Query: 14 KPVTTHTLQAMRAQGDKISMLTCYDASFATLMERAGLETVLIGDSLGMVCQGHDSTLPVT 73 K +T + L + +G K + T YDASFA L E + +L+GDSLGMV QG TLPVT Sbjct: 2 KKITINDLMKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGETDTLPVT 61 Query: 74 IQDVAYHTAAVARGTRTMLIIADLPFGTYPTREEAFRNAALLMQAGAQMIKLEGGVWLAD 133 + D+AYHT V +G+ L++AD+PF +Y T E+A NAA L++AGA M+K+EGG WL D Sbjct: 62 VDDIAYHTRCVRKGSPNCLLMADMPFMSYATPEQACENAAKLVRAGANMVKIEGGDWLVD 121 Query: 134 TIKFLTERGIPVCAHIGLTPQSVHQLGGFKVQGKTSDGATQLHADALAVQQAGASLVVIE 193 T+K LTER +PVCAH+GLTPQSV+ GG+KVQG+ D A ++ DALA+Q+AGA +V++E Sbjct: 122 TVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGREQDKADRMVRDALALQEAGAQIVLLE 181 Query: 194 AVPATLGKEVTDRLSIPTIGIGAGPDCSGQVLVMHDMLGVFPGHKSRFVRNFMDGASGIE 253 VPA L +T L +P IGIGAG GQ+LVMHDM G+ + +F +NF+ I Sbjct: 182 CVPAELANRITQILDVPVIGIGAGNGTDGQILVMHDMFGISANYMPKFSKNFLAETGDIR 241 Query: 254 EAVRRYVAAVKDGSFPAQEH 273 +AV +Y+ V G+FP H Sbjct: 242 QAVAKYIEDVASGAFPDLAH 261