BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0102.p (244 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGl2039 [IQR] COG1028 Dehydrogenases with different specificitie... 223 2e-58 mlr7680 [IQR] COG1028 Dehydrogenases with different specificitie... 219 4e-57 mll5243 [IQR] COG1028 Dehydrogenases with different specificitie... 218 1e-56 AGl561 [IQR] COG1028 Dehydrogenases with different specificities... 215 7e-56 SMc01698 [IQR] COG1028 Dehydrogenases with different specificiti... 147 2e-35 MA0415 [IQR] COG1028 Dehydrogenases with different specificities... 144 2e-34 MA0479 [IQR] COG1028 Dehydrogenases with different specificities... 141 2e-33 VCA0691 [IQR] COG1028 Dehydrogenases with different specificitie... 136 4e-32 RSc1633 [IQR] COG1028 Dehydrogenases with different specificitie... 136 4e-32 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 135 6e-32 >AGl2039 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 248 Score = 223 bits (569), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 115/244 (47%), Positives = 152/244 (62%), Gaps = 8/244 (3%) Query: 9 DFGDCVAVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPY--------RQQSIDIT 60 D AVVTGG GIG AI+ RL GA+V +WD A + +D+T Sbjct: 5 DLDGQAAVVTGGAQGIGLAIARRLIESGAKVSLWDMSETAIEQACGVLGEGASGKVVDVT 64 Query: 61 DAPAVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRS 120 D + + E+ A+TG + L+N+AG AG L++YD+ EW R+V++NL G F+ ++ Sbjct: 65 DFAGLARVHAEVEAETGPVSILVNSAGIAGSNATLEDYDIEEWRRVVEINLNGTFYVNKT 124 Query: 121 VTPAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIA 180 V P+M+A GRIVNI+S+AGKEG P SAYSAAKAGV+ LTKSLGKELA + VNAI Sbjct: 125 VIPSMKARNYGRIVNISSVAGKEGNPKLSAYSAAKAGVIGLTKSLGKELAAHDIAVNAIT 184 Query: 181 PAAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGG 240 PA +T +LE ++P + M+ + P R V+E A M AWL S SF T +VFDLSGG Sbjct: 185 PATARTRILETLTPEFIDYMLTRIPRGRFLEVEEAAAMVAWLVSRENSFTTASVFDLSGG 244 Query: 241 RATY 244 R TY Sbjct: 245 RTTY 248 >mlr7680 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 239 Score = 219 bits (558), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 116/238 (48%), Positives = 156/238 (65%), Gaps = 2/238 (0%) Query: 7 SYDFGDCVAVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPYRQQSIDITDAPAVM 66 +YDF A+VTGG GIG AI+ +L+ GA V +WD R S+D+T VM Sbjct: 4 TYDFTGRTAIVTGGARGIGRAIAHKLSLSGADVWIWDIEPVELEGTRSLSVDVTKRDNVM 63 Query: 67 QAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSVTPAMR 126 QA ++ + G +D L+NNAG+ G P +E++ EW RI+QVNLLG F V P MR Sbjct: 64 QALT-IMGEVG-VDILVNNAGWLGGYKPFEEFEPAEWQRILQVNLLGTFEVTHRVLPLMR 121 Query: 127 AAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIAPAAVKT 186 AG+GRIVN+ SLAGKEG P+ +AYSAA AGV+A TK+L +E++++ + VN IAP + T Sbjct: 122 RAGKGRIVNMGSLAGKEGLPSLAAYSAASAGVIAFTKALSREVSDTDIRVNCIAPGPIDT 181 Query: 187 ALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGGRATY 244 L+ + V MI+ SP+ RLG +EVA + WLCS + +FNTGAVFD+SGGRA Y Sbjct: 182 RLIRDLGNETVDAMISASPLKRLGDPNEVAALVVWLCSDASAFNTGAVFDMSGGRARY 239 >mll5243 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 249 Score = 218 bits (554), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 111/239 (46%), Positives = 152/239 (63%), Gaps = 11/239 (4%) Query: 15 AVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPYRQQS---------IDITDAPAV 65 AV+TGG GIG A++ R+ G ++ VWD+ D A + ++ ID+ DA V Sbjct: 13 AVITGGASGIGLAVAQRIVEEGGRISVWDR--DPAQIEQAKTVIPGLHGVAIDVADAAGV 70 Query: 66 MQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSVTPAM 125 AA + G +D L+ +A GP + Y +W +++ +N+ GVF+ R++ P M Sbjct: 71 EGAAARTIEALGGVDILVTSAAITGPNMTTWAYSTEDWQKVIDININGVFYCNRALVPHM 130 Query: 126 RAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIAPAAVK 185 GRIVNIAS+AGKEG PNASAYS +KA V+ LTKSLGKELA++ V VN + PAAV+ Sbjct: 131 LERNYGRIVNIASIAGKEGNPNASAYSTSKAAVIGLTKSLGKELAKTKVTVNCVTPAAVR 190 Query: 186 TALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGGRATY 244 TA+ +QMS H+ M++K PM R G V+EVA + W+ S CSF T AVFD+SGGRATY Sbjct: 191 TAIFKQMSQEHIDFMLSKIPMARFGEVEEVAALICWIASEECSFTTAAVFDVSGGRATY 249 >AGl561 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 253 Score = 215 bits (548), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 119/245 (48%), Positives = 151/245 (61%), Gaps = 8/245 (3%) Query: 8 YDFGDCVAVVTGGHGGIGAAISARLAAGGAQVVVWDQ----HHDAASPYRQQSIDITDAP 63 YD VAVVTG GG G AIS RL GA V+ WD A +DI+DA Sbjct: 9 YDLDGRVAVVTGATGGFGVAISQRLRDCGATVIHWDLPAAVKDGALGDLPHAGVDISDAK 68 Query: 64 AVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSVTP 123 ++ AA +L GR+D L+NNAG G PL E + E+ RI+ +NL G F CR++ P Sbjct: 69 SIETAAIDLKQRFGRLDILVNNAGIVGNVAPLWEIPIEEFRRIIDINLFGSFLVCRALVP 128 Query: 124 AM----RAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAI 179 M R + GRIVN+AS+ KEG A+AYSA+KAG++A+TKSLGKELA + +LVNAI Sbjct: 129 LMIETARTSRFGRIVNVASIQAKEGMHQAAAYSASKAGLVAMTKSLGKELATADILVNAI 188 Query: 180 APAAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSG 239 PAA TA+ + ++++ PM R EVA+M AWL S CSF+TGAVFDLSG Sbjct: 189 TPAASMTAMSIDAPKERLDDILSRIPMRRFLEPAEVANMVAWLSSSECSFSTGAVFDLSG 248 Query: 240 GRATY 244 GRATY Sbjct: 249 GRATY 253 >SMc01698 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 251 Score = 147 bits (372), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 91/238 (38%), Positives = 132/238 (55%), Gaps = 12/238 (5%) Query: 14 VAVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPY-----------RQQSIDITDA 62 +A+VTG GIGAA+S +L GA+V+V D+ DAA R ++D+TDA Sbjct: 9 IAIVTGAGSGIGAAVSRQLGGEGAEVIVADRDADAARSVAAEIRSAGGRARDFTVDVTDA 68 Query: 63 PAVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSVT 122 AV Q + + G + +NNAG GP +Y + +W R+++VNL GVF+ + Sbjct: 69 GAVEQMVAFTVRECGGLHLAVNNAGIEGPRQATADYPLEDWRRLIEVNLNGVFYCMKYEI 128 Query: 123 PAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIAPA 182 AM G G IVN++S+ G P ASAY+AAK GV+ LTK+ G E A G+ +NA+ P Sbjct: 129 AAMLGKGGGAIVNMSSILGAVALPTASAYTAAKHGVVGLTKAAGIEYARMGIRINAVGPG 188 Query: 183 AVKTALLEQMSP-AHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSG 239 ++T LL S A + + A P+ R G +EVA + +L S SF TG+ + G Sbjct: 189 WIETPLLSGHSELAKTRRLEALQPLGRRGKPEEVAALVCFLLSEQASFITGSYHPVDG 246 >MA0415 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mac Methanosarcina acetivorans str.C2A Length = 256 Score = 144 bits (363), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 87/241 (36%), Positives = 128/241 (53%), Gaps = 13/241 (5%) Query: 14 VAVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPYRQ------QSI----DITDAP 63 VA VTGG GIG A + A GA V + + A R+ Q++ D+ Sbjct: 13 VAFVTGGATGIGQATAVAFAREGANVALTYHNQGAEQTVRRIEELGGQALAIKCDVIREE 72 Query: 64 AVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSVTP 123 V A ++++ G++D+ NNAG G TV EY V EW+R++ NL GVF + P Sbjct: 73 DVKNAIEKIIQTFGQLDYAFNNAGIEGKTVITAEYPVEEWNRVIATNLTGVFLCMKYEIP 132 Query: 124 AMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIAPAA 183 M G G IVN +S AG G P+ S Y A+K GV+ LTK+ + A+S + +NA+ P Sbjct: 133 QMLKQGAGAIVNCSSGAGLTGFPDISPYVASKHGVVGLTKTAALDYAKSNIRINAVCPGM 192 Query: 184 VKTALLEQMS---PAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGG 240 T ++E+ S P + +I + P+ R+G +E+A WLCS + SF TG V + GG Sbjct: 193 TDTPMMERYSGGTPEGYEKIIEQEPIGRMGRPEEIAIAVLWLCSDAASFVTGDVMRVDGG 252 Query: 241 R 241 + Sbjct: 253 Q 253 >MA0479 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mac Methanosarcina acetivorans str.C2A Length = 258 Score = 141 bits (355), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 88/244 (36%), Positives = 127/244 (52%), Gaps = 12/244 (4%) Query: 9 DFGDCVAVVTGGHGGIGAAISARLAAGGAQVVVWDQH-----------HDAASPYRQQSI 57 +F VA+VTG G G +I+ RL AGGA V + +H + + Sbjct: 11 EFEGKVAIVTGAGTGNGESIAERLYAGGASVALVSRHIAPLDDICNRIDSSGKRTFPIEV 70 Query: 58 DITDAPAVMQAAQELLADTGRIDFLINNAGYAGP-TVPLDEYDVGEWHRIVQVNLLGVFH 116 D+ D +V A ++ G+ID +NNAG GP PL + D+ W +++ +L GVF+ Sbjct: 71 DVRDPHSVQIAVSSIIERFGKIDIAVNNAGITGPANTPLQDLDIEIWRDVIETDLTGVFY 130 Query: 117 ACRSVTPAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLV 176 + PAM G G IVN++S G G +AY+ AK GV+ LT+S ELAES + V Sbjct: 131 CMKYEIPAMLKNGSGAIVNMSSANGLVGLAGMAAYTTAKHGVIGLTRSAALELAESNIRV 190 Query: 177 NAIAPAAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFD 236 A+AP V T + + M A PM RL + +EVAD+ A+L S +F TG+V Sbjct: 191 CAVAPGYVATPRIIDSGKEAMDYMAAAHPMKRLATREEVADLVAYLLSERAAFITGSVHC 250 Query: 237 LSGG 240 + GG Sbjct: 251 IDGG 254 >VCA0691 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Vch Vibrio cholerae Length = 246 Score = 136 bits (342), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 77/240 (32%), Positives = 129/240 (53%), Gaps = 14/240 (5%) Query: 14 VAVVTGGHGGIGAAISARLAAGGAQVVV-------------WDQHHDAASPYRQQSIDIT 60 +A++TG GGIG+AIS +L + G +V+ +++ R +D+T Sbjct: 4 IALITGSKGGIGSAISTQLVSEGYRVIATYYTGNYQCALDWFNEKQFTEDQVRLLELDVT 63 Query: 61 DAPAVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRS 120 + + +LL + G ID ++NNAG +V + W ++ NL VF+ + Sbjct: 64 NTEECAERLAKLLEEEGTIDVVVNNAGITRDSV-FKKMPHQAWKEVIDTNLNSVFNVTQP 122 Query: 121 VTPAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIA 180 + AM G GRI+NI+S+ G +G + YSAAKAG++ +K+L E A GV VN IA Sbjct: 123 LFAAMCEKGFGRIINISSVNGLKGQFGQTNYSAAKAGMIGFSKALAAEGARYGVTVNVIA 182 Query: 181 PAAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGG 240 P T ++EQM +Q+++ + PM RL +E+A+ ++L S + ++ TG ++GG Sbjct: 183 PGYTLTPMVEQMRAEVLQSIVDQVPMKRLAKPEEIANAVSYLASDAAAYITGETLSVNGG 242 >RSc1633 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 246 Score = 136 bits (342), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 82/239 (34%), Positives = 124/239 (51%), Gaps = 13/239 (5%) Query: 14 VAVVTGGHGGIGAAISARLAAGGAQVVV-----------W-DQHHDAASPYRQQSIDITD 61 +A VTGG GGIG AI RLA VV W +Q + + ++ D Sbjct: 5 IAYVTGGMGGIGTAICQRLARDDFIVVAGCGPNSPRKDKWLEQQRELGFDFIASEGNVAD 64 Query: 62 APAVMQAAQELLADTGRIDFLINNAGYAGPTVPLDEYDVGEWHRIVQVNLLGVFHACRSV 121 + A ++ A+ G +D LINNAG V + +W ++ NL +F+ + V Sbjct: 65 WDSSKAAFDKVKAEVGEVDVLINNAGITRDVV-FRKMTRSDWDAVIGTNLTSLFNVTKQV 123 Query: 122 TPAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIAP 181 M G GRIVNI+S+ G++G + YS AKAG+ T +L +E+A GV VN ++P Sbjct: 124 IDGMVDRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSP 183 Query: 182 AAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGG 240 + T +++ + + +I P+ RLG +E+A +CAWL S F+TGA F L+GG Sbjct: 184 GYIATDMVKAIRQDVLDKIIGTIPVKRLGDPNEIASICAWLASEESGFSTGADFSLNGG 242 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 135 bits (341), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 78/240 (32%), Positives = 127/240 (52%), Gaps = 16/240 (6%) Query: 14 VAVVTGGHGGIGAAISARLAAGGAQVVVWDQHHDAASPYRQQS-----------IDITDA 62 V ++TG GIG A + A GA V+ D + +++ +++TD Sbjct: 7 VCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLNVTDR 66 Query: 63 PAVMQAAQELLADTGRIDFLINNAGYA--GPTVPLDEYDVGEWHRIVQVNLLGVFHACRS 120 + + ++++ GRID L+NNAG V + E D W ++ VNL GVF+ + Sbjct: 67 DQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEED---WDAVINVNLKGVFNVTQM 123 Query: 121 VTPAMRAAGRGRIVNIASLAGKEGTPNASAYSAAKAGVLALTKSLGKELAESGVLVNAIA 180 V P M G IVN++S+ G G P + Y+A+KAGV+ +TK+ KELA + VNA+A Sbjct: 124 VVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVNAVA 183 Query: 181 PAAVKTALLEQMSPAHVQTMIAKSPMHRLGSVDEVADMCAWLCSGSCSFNTGAVFDLSGG 240 P ++T + E++ +T +++ P+ R G +EVA + +L S S+ TG V + GG Sbjct: 184 PGFIETPMTEKLPEKARETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIGIDGG 243