BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0027.p (249 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll5766 [IQR] COG1028 Dehydrogenases with different specificitie... 302 4e-82 SMc00268 [IQR] COG1028 Dehydrogenases with different specificiti... 281 9e-76 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 171 2e-42 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 170 3e-42 fabG [IQR] COG1028 Dehydrogenases with different specificities (... 168 1e-41 ZfabG [IQR] COG1028 Dehydrogenases with different specificities ... 167 1e-41 ECs1471 [IQR] COG1028 Dehydrogenases with different specificitie... 167 1e-41 RSc1052 [IQR] COG1028 Dehydrogenases with different specificitie... 166 6e-41 CT237 [IQR] COG1028 Dehydrogenases with different specificities ... 165 8e-41 PM1916 [IQR] COG1028 Dehydrogenases with different specificities... 164 1e-40 >mll5766 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 250 Score = 302 bits (774), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 153/249 (61%), Positives = 184/249 (73%) Query: 1 MLLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVA 60 MLLK K +I+G A G+G STA LMA QGARI ILDL+ + AAA LG +H+GL Sbjct: 1 MLLKGKAVVISGAASPRGIGRSTATLMAEQGARIAILDLDEEQARDAAASLGPEHIGLAC 60 Query: 61 DVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMS 120 +V D SC+ AAA V + FGR+++L N AG+TQP K L+I D+DRILDV+LRG LY+S Sbjct: 61 NVADLDSCKRAAAEVTEAFGRVEVLCNIAGITQPVKTLDIGPADWDRILDVNLRGVLYLS 120 Query: 121 QAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRV 180 QA +P M+ GSI+C+SSVSAQRGGGI GGPHYSAAKAGVLGLA+AMAREFGP GIR+ Sbjct: 121 QAFIPHMRENGGGSIICMSSVSAQRGGGIFGGPHYSAAKAGVLGLAKAMAREFGPDGIRI 180 Query: 181 NCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTL 240 NCVTPGLI TDI L+ + +I + IPL RLG DV G +FLASDL+ Y TG + Sbjct: 181 NCVTPGLIQTDITGGKLTDAMRADIIKGIPLSRLGDARDVAGAYLFLASDLASYITGAVI 240 Query: 241 DVNGGMLIH 249 DVNGGMLIH Sbjct: 241 DVNGGMLIH 249 >SMc00268 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 252 Score = 281 bits (719), Expect = 9e-76, Method: Compositional matrix adjust. Identities = 146/248 (58%), Positives = 182/248 (73%) Query: 2 LLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVAD 61 LL+ A+ITG A + GLG +TARL A GA + ILDL+ A+ AAA LG +H+G+ + Sbjct: 5 LLEGNFAVITGAASRRGLGKATARLFAEHGATVAILDLDEADAREAAASLGPRHVGMACN 64 Query: 62 VTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMSQ 121 VTD AS A++ Q+GRIDILVNNAG+TQP K++EI ++YD +LDV+LRGTLY SQ Sbjct: 65 VTDLASVRTVMDALVSQWGRIDILVNNAGITQPLKIMEIAPENYDAVLDVNLRGTLYCSQ 124 Query: 122 AVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRVN 181 AV+P M++++ G IV +SSVSAQRGGGI GGPHYSAAKAGVLGL +AMARE P +RVN Sbjct: 125 AVIPHMRSRKQGKIVNLSSVSAQRGGGIFGGPHYSAAKAGVLGLTKAMARELAPDNVRVN 184 Query: 182 CVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTLD 241 + PG I+TDI +L+ EK EI IP+GR G DDV G +FLASDLS Y TG +D Sbjct: 185 AICPGFIATDITGGLLTPEKLEEIKAGIPMGRPGTADDVAGCALFLASDLSAYVTGSEVD 244 Query: 242 VNGGMLIH 249 VNGG LIH Sbjct: 245 VNGGSLIH 252 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 171 bits (432), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 100/251 (39%), Positives = 149/251 (59%), Gaps = 9/251 (3%) Query: 2 LLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVIL---DLERAEPAGAAAR-LGVQHLG 57 +L+ K AI+TG + G+G +TA +A GA +V+ + E+AE A + LGV+ + Sbjct: 1 MLQGKTAIVTGAS--RGIGRATAMELARHGANVVVNYAGNKEKAEKVVAEIKELGVEAIA 58 Query: 58 LVADVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTL 117 + ADV D S +A + FG +DILVNNAG+T+ + + +D+D ++D +L+G Sbjct: 59 IQADVADSESVQAMVKETIDTFGAVDILVNNAGITRDNLFMRMKEEDWDAVIDTNLKGVF 118 Query: 118 YMSQAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQG 177 + S+AV M Q+ G I+ +SSV G G +Y AAKAGV+GL + +ARE + Sbjct: 119 HCSKAVTRPMMKQRFGRIINVSSVVGAIGNA--GQANYVAAKAGVIGLTKTLARELANRN 176 Query: 178 IRVNCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTG 237 I VN V PG I TD+ + L + K ++ IPL RLG P++V FLASD + Y TG Sbjct: 177 ITVNAVAPGFIETDMTGE-LPEDVKAQMLGQIPLARLGQPEEVAKAVRFLASDDASYLTG 235 Query: 238 VTLDVNGGMLI 248 T+ VNGGM++ Sbjct: 236 QTIHVNGGMVM 246 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 170 bits (430), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 97/258 (37%), Positives = 158/258 (61%), Gaps = 22/258 (8%) Query: 1 MLLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERA-------EPAGAAARLGV 53 M L+ KV +ITG A +G+G +T L A +GA ++ D+ + E G ++ Sbjct: 1 MRLEGKVCLITGAA--SGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVD- 57 Query: 54 QHLGLVADVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSL 113 V +VTD+ + V++++GRID+LVNNAG+T+ A L+ + +D+D +++V+L Sbjct: 58 ---PYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNL 114 Query: 114 RGTLYMSQAVLPAMQAQQSGSIVCISSVSAQRGGGILGGP---HYSAAKAGVLGLARAMA 170 +G ++Q V+P M Q++GSIV +SSV GI G P +Y+A+KAGV+G+ + A Sbjct: 115 KGVFNVTQMVVPYMIKQRNGSIVNVSSVV-----GIYGNPGQTNYAASKAGVIGMTKTWA 169 Query: 171 REFGPQGIRVNCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASD 230 +E + IRVN V PG I T + + + ++T +++ IPLGR G P++V V +FLASD Sbjct: 170 KELAGRNIRVNAVAPGFIETPMTEKLPEKARETALSR-IPLGRFGKPEEVAQVILFLASD 228 Query: 231 LSQYCTGVTLDVNGGMLI 248 S Y TG + ++GG++I Sbjct: 229 ESSYVTGQVIGIDGGLVI 246 >fabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Eco Escherichia coli K12 Length = 244 Score = 168 bits (426), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 93/248 (37%), Positives = 148/248 (59%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVA 60 M + K+A++TG + G+G + A +AA+GA+++ + LG GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMS 120 +VTD AS E+ + +FG +DILVNNAG+T+ L+ + ++++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRV 180 +AV+ AM ++ G I+ I SV G G G +Y+AAKAG++G ++++ARE +GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTL 240 N V PG I TD+ + LS +++ I +P GRLGG ++ FLASD + Y TG TL Sbjct: 177 NVVAPGFIETDMTR-ALSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >ZfabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) EcZ Escherichia coli O157:H7 EDL933 Length = 244 Score = 167 bits (424), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 93/248 (37%), Positives = 148/248 (59%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVA 60 M + K+A++TG + G+G + A +AA+GA+++ + LG GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMS 120 +VTD AS E+ + +FG +DILVNNAG+T+ L+ + ++++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRV 180 +AV+ AM ++ G I+ I SV G G G +Y+AAKAG++G ++++ARE +GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTL 240 N V PG I TD+ + LS +++ I +P GRLGG ++ FLASD + Y TG TL Sbjct: 177 NVVAPGFIETDMTR-ALSDDQRAGILVQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >ECs1471 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ecs Escherichia coli O157:H7 Length = 244 Score = 167 bits (424), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 93/248 (37%), Positives = 148/248 (59%), Gaps = 5/248 (2%) Query: 1 MLLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVA 60 M + K+A++TG + G+G + A +AA+GA+++ + LG GL+ Sbjct: 1 MNFEGKIALVTGAS--RGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLML 58 Query: 61 DVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMS 120 +VTD AS E+ + +FG +DILVNNAG+T+ L+ + ++++ I++ +L +S Sbjct: 59 NVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLS 118 Query: 121 QAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRV 180 +AV+ AM ++ G I+ I SV G G G +Y+AAKAG++G ++++ARE +GI V Sbjct: 119 KAVMRAMMKKRHGRIITIGSVVGTMGNG--GQANYAAAKAGLIGFSKSLAREVASRGITV 176 Query: 181 NCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTL 240 N V PG I TD+ + LS +++ I +P GRLGG ++ FLASD + Y TG TL Sbjct: 177 NVVAPGFIETDMTR-ALSDDQRAGILVQVPAGRLGGAQEIANAVAFLASDEAAYITGETL 235 Query: 241 DVNGGMLI 248 VNGGM + Sbjct: 236 HVNGGMYM 243 >RSc1052 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 249 Score = 166 bits (419), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 102/249 (40%), Positives = 144/249 (57%), Gaps = 8/249 (3%) Query: 3 LKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARL---GVQHLGLV 59 L ++VA++TG + G+G + A +A QGA +V A +A GV+ G+V Sbjct: 5 LNNQVALVTGAS--RGIGRAIALELARQGATVVGTATSEAGAQAISAYFAEAGVKGAGVV 62 Query: 60 ADVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYM 119 +V D A CEA +K G ++ILVNNAG+TQ + + ++ ++D +L + Sbjct: 63 LNVNDAARCEAVIDEAIKTHGGLNILVNNAGITQDNLAMRMKDDEWMAVIDTNLSAVFRL 122 Query: 120 SQAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIR 179 S+AVL M + G I+ I+SV G G +Y+AAKAGV G+ARAMA+E G + I Sbjct: 123 SRAVLRPMMKARGGRIINITSVVGSAGN--PGQANYAAAKAGVEGMARAMAKEIGSRNIT 180 Query: 180 VNCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVT 239 VN V PG I TD+ K +LS E+ T + IPLGRLG P+D+ FLAS + Y TG T Sbjct: 181 VNSVAPGFIDTDMTK-VLSDEQHTALKAQIPLGRLGMPEDIANAVAFLASPAAGYITGAT 239 Query: 240 LDVNGGMLI 248 L VNGGM + Sbjct: 240 LHVNGGMYM 248 >CT237 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ctr Chlamydia trachomatis Length = 248 Score = 165 bits (418), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 96/250 (38%), Positives = 147/250 (58%), Gaps = 11/250 (4%) Query: 2 LLKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQ-----HL 56 LL +K AI+TGG+ G+GFS A+L A QGA + I + AA L Q Sbjct: 4 LLVNKTAIVTGGS--RGIGFSIAKLFAEQGANVQIWGINGEAGQAAAQTLSEQTGRQVSF 61 Query: 57 GLVADVTDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGT 116 LV DV+ A L ++ ID++VNNAG+T+ A L+ ++ +++ +++ +L Sbjct: 62 ALV-DVSKNDMVSAQVQNFLAEYNTIDVIVNNAGITRDALLMRMSEEEWSSVINTNLGSI 120 Query: 117 LYMSQAVLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQ 176 + AV+ M +SG+I+ ISS+ RG G +Y+AAKAG++G ++A+++E G + Sbjct: 121 YNVCSAVIRPMIKARSGAIINISSIVGLRGSP--GQTNYAAAKAGIIGFSKALSKEVGSK 178 Query: 177 GIRVNCVTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCT 236 IRVNC+ PG I TD+ K L+ K E + +PLGR+G P+++ +FLASD S Y T Sbjct: 179 NIRVNCIAPGFIDTDMTKS-LNDNLKNEWLKGVPLGRVGMPEEIAKAALFLASDGSSYIT 237 Query: 237 GVTLDVNGGM 246 G L V+GGM Sbjct: 238 GQVLSVDGGM 247 >PM1916 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pmu Pasteurella multocida Length = 242 Score = 164 bits (416), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 94/247 (38%), Positives = 145/247 (58%), Gaps = 5/247 (2%) Query: 3 LKDKVAIITGGAGQNGLGFSTARLMAAQGARIVILDLERAEPAGAAARLGVQHLGLVADV 62 ++ K+A++TG G+G + A ++A+GA ++ +A LG + GLV +V Sbjct: 1 MQGKIALVTGAT--RGIGRAIAEELSAKGAFVIGTATSEKGAESISAYLGEKGKGLVLNV 58 Query: 63 TDKASCEAAAAAVLKQFGRIDILVNNAGVTQPAKLLEITGKDYDRILDVSLRGTLYMSQA 122 +D AS E + FG IDILVNNAG+T+ L+ + +++ I+ +L ++S+A Sbjct: 59 SDLASIETTLEKIKADFGEIDILVNNAGITRDNLLMRMKDEEWFDIMQTNLTSVYHLSKA 118 Query: 123 VLPAMQAQQSGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGPQGIRVNC 182 +L +M ++ G I+ I SV G G +Y AAKAG++G ++A+A+E +GI VN Sbjct: 119 MLRSMMKKRFGRIITIGSVVGSMGNP--GQTNYCAAKAGLIGFSKALAKEVASRGITVNV 176 Query: 183 VTPGLISTDINKDILSAEKKTEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGVTLDV 242 V PG I+TD+ D+L+ E+K I +P GRLG P D+ FLASD + Y TG TL V Sbjct: 177 VAPGFIATDMT-DVLTEEQKAGILSQVPAGRLGDPKDIAKAVAFLASDDAGYITGTTLHV 235 Query: 243 NGGMLIH 249 NGGM + Sbjct: 236 NGGMYTN 242