BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0022.p (275 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value XF1717 [R] COG0325 Predicted enzyme with a TIM-barrel fold Xfa X... 337 2e-92 aq_274 [R] COG0325 Predicted enzyme with a TIM-barrel fold Aae A... 167 2e-41 BH2550 [R] COG0325 Predicted enzyme with a TIM-barrel fold Bha B... 166 6e-41 PM0112 [R] COG0325 Predicted enzyme with a TIM-barrel fold Pmu P... 162 7e-40 BS_ylmE [R] COG0325 Predicted enzyme with a TIM-barrel fold Bsu ... 159 9e-39 HI0090 [R] COG0325 Predicted enzyme with a TIM-barrel fold Hin H... 153 3e-37 VC0461 [R] COG0325 Predicted enzyme with a TIM-barrel fold Vch V... 147 3e-35 RSc2683 [R] COG0325 Predicted enzyme with a TIM-barrel fold Rso ... 146 6e-35 MA0493 [R] COG0325 Predicted enzyme with a TIM-barrel fold Mac M... 144 1e-34 STM3100 [R] COG0325 Predicted enzyme with a TIM-barrel fold Sty ... 144 2e-34 >XF1717 [R] COG0325 Predicted enzyme with a TIM-barrel fold Xfa Xylella fastidiosa 9a5c Length = 266 Score = 337 bits (864), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 164/238 (68%), Positives = 193/238 (81%) Query: 32 SLDEFRANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKP 91 ++++ R+NL V+ RI AAC+R R SSV LLPVSKT E IRL+Y AGCR LGENK Sbjct: 25 TVEDIRSNLTKVYSRIIAACQRVDRHPSSVTLLPVSKTVDEVHIRLSYEAGCRKLGENKA 84 Query: 92 QEACHKWEATQDLSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGR 151 Q+A HKWEA DL+ L WSVIGHLQTNKAKLVARFA+EFQALDSLRVA+ALERRLQ EGR Sbjct: 85 QDAYHKWEAMSDLTDLHWSVIGHLQTNKAKLVARFASEFQALDSLRVAEALERRLQIEGR 144 Query: 152 GLDVFVQVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFS 211 LDV +QVNTSGE +KYGL PEEV F++ L AYPALR+RGLMTLA+ S + +RVR CF+ Sbjct: 145 SLDVLIQVNTSGETNKYGLPPEEVVRFVQALSAYPALRVRGLMTLALLSGDTSRVRQCFT 204 Query: 212 LLRNLRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGARALPDSHY 269 LR LR+R++Q P G + ELSMGMSGD EIAIEEGATVVRVGQA++GARALP+ H+ Sbjct: 205 QLRILRDRIQQASPQGHHITELSMGMSGDLEIAIEEGATVVRVGQAIYGARALPNLHF 262 >aq_274 [R] COG0325 Predicted enzyme with a TIM-barrel fold Aae Aquifex aeolicus Length = 228 Score = 167 bits (424), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 93/223 (41%), Positives = 127/223 (56%), Gaps = 3/223 (1%) Query: 40 LAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACHKWE 99 L+ V RI ACERAGR + +LL SKT P IR Y G ++ GEN+ QE K+E Sbjct: 7 LSRVLERIQKACERAGRGENCAKLLGASKTVPPEVIREFYNCGLKVYGENRVQEFLKKYE 66 Query: 100 ATQDLSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRGLDVFVQV 159 A +DL L+W IG LQTNK K + +LD +A +++R + DV ++V Sbjct: 67 ALKDLD-LEWHFIGRLQTNKVKYLMGKVVLIHSLDRKNLADEIQKRAFKNNIVQDVLIEV 125 Query: 160 NTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLRNLRER 219 N GE +K G+ PE + P +++ GLMT+ + P VRP F LR LR+ Sbjct: 126 NVGGEETKGGVEPENLKELFEYTLELPNVKVLGLMTIPPYLENPEDVRPYFRKLRELRDE 185 Query: 220 LRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGAR 262 L+++ L LSMGMS D+E+AIEEGAT+VR+G LFG R Sbjct: 186 LQRE--YNVALPHLSMGMSHDFEVAIEEGATIVRIGTLLFGER 226 >BH2550 [R] COG0325 Predicted enzyme with a TIM-barrel fold Bha Bacillus halodurans Length = 228 Score = 166 bits (420), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 96/225 (42%), Positives = 133/225 (59%), Gaps = 5/225 (2%) Query: 37 RANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACH 96 + L + ++ ACERAGR V ++ V+K E+ R A AG +GEN+ + Sbjct: 4 KDQLKQIQEQMNEACERAGRNPDDVHIIAVTKYVSEARTREALEAGITHIGENRVEGGVE 63 Query: 97 KWEATQDLSGLQWSVIGHLQTNKAK-LVARFAAEFQALDSLRVAQALERRLQQEGRGLDV 155 K A + W IG LQ+ K K ++A F +LD L +A+ ++RRL +G+ L+ Sbjct: 64 KRRAFPNEG--TWHFIGSLQSKKVKKMIADFDY-LHSLDRLSLAKEIDRRLP-DGQALNC 119 Query: 156 FVQVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLRN 215 FVQVN SGE SK GL PEEV PF+ +L YP++R+ GLMT+A F +P R F LR+ Sbjct: 120 FVQVNVSGEQSKSGLKPEEVLPFIEELQTYPSIRVVGLMTMAPFVEDPEDTRWVFRELRH 179 Query: 216 LRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFG 260 LR+ ++ A ELSMGMS D+ +AIEEGAT VR+G AL G Sbjct: 180 LRDEVQAKRFNHAPCSELSMGMSNDFIVAIEEGATFVRIGTALVG 224 >PM0112 [R] COG0325 Predicted enzyme with a TIM-barrel fold Pmu Pasteurella multocida Length = 233 Score = 162 bits (411), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 94/225 (41%), Positives = 130/225 (57%), Gaps = 2/225 (0%) Query: 39 NLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACHKW 98 NLA + + I A ++A RP S+V+LL VSKTKP I AY AG GEN QE K Sbjct: 6 NLAQIQQNIQHAVQQAKRPESAVKLLAVSKTKPVEDIYQAYQAGQTAFGENYVQEGVEKI 65 Query: 99 EA-TQDLSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRGLDVFV 157 + Q L+W IG LQ+NK KLVA Q LD ++A L + + L+V + Sbjct: 66 QYFAQKNIPLEWHFIGPLQSNKTKLVAEHFDWMQTLDRKKIADRLNEQRPHYKKPLNVLI 125 Query: 158 QVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLRNLR 217 Q+N S E SK G+ P E+ +Q+ P L LRGLM + + + A F+ + +L Sbjct: 126 QINISDEDSKSGIQPNEMLDLAKQIQNLPHLCLRGLMAIPAPTDDLATQEQAFTQMHSLF 185 Query: 218 ERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGAR 262 E+L+Q +P AQ+D LSMGM+ D AI+ G+T+VR+G A+FGAR Sbjct: 186 EQLKQALP-DAQIDTLSMGMTDDMASAIQCGSTMVRIGTAIFGAR 229 >BS_ylmE [R] COG0325 Predicted enzyme with a TIM-barrel fold Bsu Bacillus subtilis Length = 230 Score = 159 bits (401), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 89/222 (40%), Positives = 130/222 (58%), Gaps = 5/222 (2%) Query: 39 NLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACHKW 98 NL ++ RI AC R+GR + V ++ V+K + A AG LGEN+ E K Sbjct: 6 NLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQEAVDAGITCLGENRDAELLRKQ 65 Query: 99 EATQDLSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRGLDVFVQ 158 E + +W IG LQ+ KAK V + +LD L +A+ +E+R + R FVQ Sbjct: 66 ELMK--GNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLSLAKEIEKRAEGTVR---CFVQ 120 Query: 159 VNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLRNLRE 218 VNTS E SK+G+ EEV PF+++L + + + GLMT+A + + ++R CF LR LR+ Sbjct: 121 VNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAPLTDDQDQIRSCFRSLRELRD 180 Query: 219 RLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFG 260 ++++ A ELSMGMS D+EIAIEEGAT +R+G +L G Sbjct: 181 QVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGSSLVG 222 >HI0090 [R] COG0325 Predicted enzyme with a TIM-barrel fold Hin Haemophilus influenzae Length = 237 Score = 153 bits (387), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 90/234 (38%), Positives = 127/234 (54%), Gaps = 2/234 (0%) Query: 36 FRANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEAC 95 + NL + ++I AC+ R ++V+LL VSKTKP S+I AY AG GEN QE Sbjct: 3 IQHNLNLIQQKIETACKEENRNQNTVKLLAVSKTKPISAILSAYQAGQTAFGENYVQEGV 62 Query: 96 HKWEATQDLS-GLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRGLD 154 K + + L+W IG LQ+NK +LVA Q LD ++A L + L+ Sbjct: 63 EKIQYFESQGINLEWHFIGPLQSNKTRLVAEHFDWMQTLDRAKIADRLNEQRPTNKAPLN 122 Query: 155 VFVQVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLR 214 V +Q+N S E SK G+ PEE+ + + P L LRGLM + + A F + Sbjct: 123 VLIQINISDEESKSGIQPEEMLTLAKHIENLPHLCLRGLMAIPAPTDNIAEQENAFRKML 182 Query: 215 NLRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGARALPDSH 268 L E+L+Q +P Q+D LSMGM+ D AI+ G+T+VR+G A+FGAR S Sbjct: 183 ELFEQLKQVLP-NQQIDTLSMGMTDDMPSAIKCGSTMVRIGTAIFGARNYSTSQ 235 >VC0461 [R] COG0325 Predicted enzyme with a TIM-barrel fold Vch Vibrio cholerae Length = 236 Score = 147 bits (370), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 93/231 (40%), Positives = 131/231 (56%), Gaps = 8/231 (3%) Query: 36 FRANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEAC 95 + N+ + +I +A ++ GR SSV+LL VSKTKP +I A AG R GEN QE Sbjct: 4 IQQNIEHITAQIESAQQKCGRARSSVQLLAVSKTKPVEAILEATQAGQRYFGENYVQEGV 63 Query: 96 HK---WEATQDLSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRG 152 K + L+W IG LQ+NK +LVA +D ++A L + Sbjct: 64 DKIRYFAEHHPQLALEWHFIGPLQSNKTRLVAEHFDWVHTIDREKIALRLSEQRPVNMPP 123 Query: 153 LDVFVQVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPE-PARVRPCFS 211 L V +QVNTSGEASK G+ P+++ + P L LRGLM++ P+ PA++ F+ Sbjct: 124 LQVLIQVNTSGEASKSGIEPQQLFTLAELISRLPNLTLRGLMSIPENVPDYPAQL-AAFT 182 Query: 212 LLRNLRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGAR 262 L L+++L Q P Q+D LSMGMSGD + AIE G+T+VR+G A+FG R Sbjct: 183 QLAELQQQLAQKYP---QIDTLSMGMSGDMQAAIEAGSTIVRIGTAIFGER 230 >RSc2683 [R] COG0325 Predicted enzyme with a TIM-barrel fold Rso Ralstonia solanacearum Length = 240 Score = 146 bits (368), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 107/235 (45%), Positives = 136/235 (57%), Gaps = 17/235 (7%) Query: 38 ANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACHK 97 ANL AV +RI AC A R +SV LL VSKT ++R A+AAG RL GEN QE K Sbjct: 6 ANLQAVRQRITTACTLASRDPASVTLLAVSKTFDADAVRAAHAAGQRLFGENYVQEGTAK 65 Query: 98 WEATQDL----SGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEGRGL 153 A DL + W IG LQ+NK + VA ++D L++A+ L + L Sbjct: 66 TSALTDLRNGPEAIAWHFIGPLQSNKTRAVAEHFDWVHSIDRLKIAERLSAQRPATLPPL 125 Query: 154 DVFVQVNTSGEASKYGLAP--EEVAPFLRQLHAYPALRLRGLMTLAVFSPEPA----RVR 207 V +++N S +ASK+G+ P +EV P R + A P LRLRGLM + PEPA R Sbjct: 126 QVCLEINISRQASKHGVPPDLDEVLPLARAVAALPRLRLRGLMAV----PEPADDPAARR 181 Query: 208 PCFSLLRNLRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGAR 262 F+ LR+L +RL AG +D LSMGMS D E AI EGAT+VRVG A+FGAR Sbjct: 182 APFAALRDLADRL---CAAGLPVDTLSMGMSADLEDAIAEGATIVRVGSAIFGAR 233 >MA0493 [R] COG0325 Predicted enzyme with a TIM-barrel fold Mac Methanosarcina acetivorans str.C2A Length = 216 Score = 144 bits (364), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 78/203 (38%), Positives = 118/203 (58%), Gaps = 4/203 (1%) Query: 60 SVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQEACHKWEATQDLSGLQWSVIGHLQTNK 119 S L+ V+KT I A AG ++GEN+ QE K + D+ + +IGHLQTNK Sbjct: 16 STTLVCVTKTIEPERINEAIRAGAPIIGENRVQEYEDKRD---DILPCETHLIGHLQTNK 72 Query: 120 AKLVARFAAEFQALDSLRVAQALERRLQQEGRGLDVFVQVNTSGEASKYGLAPEEVAPFL 179 K Q++DS+++ + ++RR + G+ V++QVN E KYG P+E+ + Sbjct: 73 VKKAVHLFDVIQSIDSMKIIRDIDRRARDIGKVQKVYLQVNIGNEPQKYGFGPDEIKNAI 132 Query: 180 RQLHAYPALRLRGLMTLAVFSPEPARVRPCFSLLRNLRERLRQDVPAGAQLDELSMGMSG 239 ++ + +R+ GLM + F P P + RP F ++ L + ++Q+ + LSMGMSG Sbjct: 133 TEIRSLRNVRVEGLMCIPPFVP-PEQTRPYFKKMKALFDEMKQENRDNIDIRTLSMGMSG 191 Query: 240 DYEIAIEEGATVVRVGQALFGAR 262 DY IAIEEGAT+VRVG A+FG R Sbjct: 192 DYRIAIEEGATMVRVGSAIFGKR 214 >STM3100 [R] COG0325 Predicted enzyme with a TIM-barrel fold Sty Salmonella typhimurium LT2 Length = 234 Score = 144 bits (362), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 94/232 (40%), Positives = 125/232 (53%), Gaps = 5/232 (2%) Query: 33 LDEFRANLAAVHRRIAAACERAGRPASSVRLLPVSKTKPESSIRLAYAAGCRLLGENKPQ 92 +++ NLA + +I+AA R GR + V LL VSKTKP S I A AAG R GEN Q Sbjct: 1 MNDIAHNLAYIRDKISAAATRCGRSSEEVTLLAVSKTKPASDIAEAIAAGQRAFGENYVQ 60 Query: 93 EACHKWEATQD--LSGLQWSVIGHLQTNKAKLVARFAAEFQALDSLRVAQALERRLQQEG 150 E K Q+ + GL W IG LQ+NK++LVA +D LR+A L + Sbjct: 61 EGVEKIRHFQEAKVEGLHWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIASRLSEQRPDNL 120 Query: 151 RGLDVFVQVNTSGEASKYGLAPEEVAPFLRQLHAYPALRLRGLMTLAVFSPEPARVRPCF 210 L+V +Q+N S E SK G+ E+ + P LRLRGLM A+ +PE VR F Sbjct: 121 PALNVLIQINISDENSKSGIPLAELDELAAAVATLPRLRLRGLM--AIPAPESDYVRQ-F 177 Query: 211 SLLRNLRERLRQDVPAGAQLDELSMGMSGDYEIAIEEGATVVRVGQALFGAR 262 + R + +D LS+GMS D E AI G+T+VR+G A+FGAR Sbjct: 178 EVARQMAVAFAGLKARYPDVDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGAR 229