BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0058.p (246 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0399 [L] COG0266 Formamidopyrimidine-DNA glycosylase Rso Rals... 288 5e-78 PA0357 [L] COG0266 Formamidopyrimidine-DNA glycosylase Pae Pseud... 249 4e-66 mutM [L] COG0266 Formamidopyrimidine-DNA glycosylase Eco Escheri... 226 3e-59 ZmutM [L] COG0266 Formamidopyrimidine-DNA glycosylase EcZ Escher... 226 3e-59 ECs4510 [L] COG0266 Formamidopyrimidine-DNA glycosylase Ecs Esch... 226 3e-59 STM3726 [L] COG0266 Formamidopyrimidine-DNA glycosylase Sty Salm... 219 5e-57 XF0170 [L] COG0266 Formamidopyrimidine-DNA glycosylase Xfa Xylel... 218 7e-57 XF0071 [L] COG0266 Formamidopyrimidine-DNA glycosylase Xfa Xylel... 218 7e-57 YPO0052 [L] COG0266 Formamidopyrimidine-DNA glycosylase Ype Yers... 218 9e-57 NMB1295 [L] COG0266 Formamidopyrimidine-DNA glycosylase Nme Neis... 216 3e-56 >RSc0399 [L] COG0266 Formamidopyrimidine-DNA glycosylase Rso Ralstonia solanacearum Length = 288 Score = 288 bits (738), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 149/261 (57%), Positives = 179/261 (68%), Gaps = 15/261 (5%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIH----FDHGT------LIVHLGMSG 50 +RH GLRWP L LL GR + RRGKYLLI HG L+VHLGM+G Sbjct: 28 VRHHGLRWPVDPALPELLGGRTVARVLRRGKYLLIECVPDIAHGPQAGAGWLLVHLGMTG 87 Query: 51 HLRILPPGIAPQKHDHFDLEVGGQ-----VMRMTDPRRFGAILWHDLADGAVEEHLLLRS 105 LR+L AP HDH D+E+ +R DPRRFGA+LWHD + A+ H LLR+ Sbjct: 88 TLRVLETPAAPGTHDHLDIELADAAGRPITLRYRDPRRFGAVLWHDGDEAALSAHPLLRN 147 Query: 106 LGLEPLEEKFTARELFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAG 165 LG+EP + +F ++ +TRGRSA IK VLLAGDIVVGVGNIY SESLF+A I P TAAG Sbjct: 148 LGIEPFDTRFDGDWMYARTRGRSAAIKTVLLAGDIVVGVGNIYCSESLFRAGIRPTTAAG 207 Query: 166 KISLPRYERLAQAIRETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICA 225 +IS PRY LA+AIR TLA AI +GGS+LRDF+ +GQSGYFQ + VY+R G CR+C Sbjct: 208 RISRPRYAALAEAIRATLADAIARGGSTLRDFVGSDGQSGYFQLDALVYDRAGLPCRVCG 267 Query: 226 TPIRQIKQGQRSTFYCVSCQK 246 TPIRQI QGQRSTFYC +CQ+ Sbjct: 268 TPIRQIVQGQRSTFYCPACQR 288 >PA0357 [L] COG0266 Formamidopyrimidine-DNA glycosylase Pae Pseudomonas aeruginosa Length = 270 Score = 249 bits (636), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 126/247 (51%), Positives = 165/247 (66%), Gaps = 5/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R LRWP P L+ L G+ I S RR KYLL+ + GTLI HLGMSG LR++ G Sbjct: 28 VRERRLRWPIPEDLDVRLSGQRIVSVERRAKYLLLGAEAGTLISHLGMSGSLRLVESGTP 87 Query: 61 PQKHDHFDLEVG-GQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTARE 119 +H+H D+E+ G +R TDPRRFGA+LW A EH LLR+LG EPL + F + Sbjct: 88 ASRHEHVDIELASGMALRYTDPRRFGAMLWSL----APLEHELLRNLGPEPLTDAFAGQR 143 Query: 120 LFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQAI 179 LF +RGRS +K ++ +VVGVGNIYASE+LF A I P+ AG IS RY RLA+ I Sbjct: 144 LFELSRGRSMAVKPFIMDNAVVVGVGNIYASEALFAAGIDPRKPAGSISKARYLRLAEEI 203 Query: 180 RETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRSTF 239 + LA AIE+GG++LRDF+ +GQ GYFQQ FVY R GE C++C + +R+I+ GQR++ Sbjct: 204 KRILAIAIERGGTTLRDFVGGDGQPGYFQQELFVYGRGGEFCKVCGSTLREIRLGQRASV 263 Query: 240 YCVSCQK 246 YC CQ+ Sbjct: 264 YCPRCQR 270 >mutM [L] COG0266 Formamidopyrimidine-DNA glycosylase Eco Escherichia coli K12 Length = 269 Score = 226 bits (577), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 120/247 (48%), Positives = 152/247 (61%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R+ LRWP + L V+ S RR KYLL+ G +I+HLGMSG LRILP + Sbjct: 28 VRNGRLRWPVSEEIYRLSDQPVL-SVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELP 86 Query: 61 PQKHDHFDLEV-GGQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTARE 119 P+KHDH DL + G+V+R TDPRRFGA LW +G H +L LG EPL + F Sbjct: 87 PEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEG----HNVLTHLGPEPLSDDFNGEY 142 Query: 120 LFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQAI 179 L ++ + IK L+ +VVGVGNIYASESLF A IHP A +SL E LA+ I Sbjct: 143 LHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVI 202 Query: 180 RETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRSTF 239 + L +IEQGG++L+DF+ +G+ GYF Q VY R GE CR+C TPI K QR+TF Sbjct: 203 KAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATF 262 Query: 240 YCVSCQK 246 YC CQK Sbjct: 263 YCRQCQK 269 >ZmutM [L] COG0266 Formamidopyrimidine-DNA glycosylase EcZ Escherichia coli O157:H7 EDL933 Length = 269 Score = 226 bits (577), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 120/247 (48%), Positives = 152/247 (61%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R+ LRWP + L V+ S RR KYLL+ G +I+HLGMSG LRILP + Sbjct: 28 VRNGRLRWPVSEEIYRLSDQPVL-SVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELP 86 Query: 61 PQKHDHFDLEV-GGQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTARE 119 P+KHDH DL + G+V+R TDPRRFGA LW +G H +L LG EPL + F Sbjct: 87 PEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEG----HNVLAHLGPEPLSDDFNGEY 142 Query: 120 LFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQAI 179 L ++ + IK L+ +VVGVGNIYASESLF A IHP A +SL E LA+ I Sbjct: 143 LHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVI 202 Query: 180 RETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRSTF 239 + L +IEQGG++L+DF+ +G+ GYF Q VY R GE CR+C TPI K QR+TF Sbjct: 203 KAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATF 262 Query: 240 YCVSCQK 246 YC CQK Sbjct: 263 YCRQCQK 269 >ECs4510 [L] COG0266 Formamidopyrimidine-DNA glycosylase Ecs Escherichia coli O157:H7 Length = 269 Score = 226 bits (577), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 120/247 (48%), Positives = 152/247 (61%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R+ LRWP + L V+ S RR KYLL+ G +I+HLGMSG LRILP + Sbjct: 28 VRNGRLRWPVSEEIYRLSDQPVL-SVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELP 86 Query: 61 PQKHDHFDLEV-GGQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTARE 119 P+KHDH DL + G+V+R TDPRRFGA LW +G H +L LG EPL + F Sbjct: 87 PEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEG----HNVLAHLGPEPLSDDFNGEY 142 Query: 120 LFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQAI 179 L ++ + IK L+ +VVGVGNIYASESLF A IHP A +SL E LA+ I Sbjct: 143 LHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVI 202 Query: 180 RETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRSTF 239 + L +IEQGG++L+DF+ +G+ GYF Q VY R GE CR+C TPI K QR+TF Sbjct: 203 KAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATF 262 Query: 240 YCVSCQK 246 YC CQK Sbjct: 263 YCRQCQK 269 >STM3726 [L] COG0266 Formamidopyrimidine-DNA glycosylase Sty Salmonella typhimurium LT2 Length = 269 Score = 219 bits (558), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 116/247 (46%), Positives = 151/247 (61%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R+ LRWP + L V+ S RR KYLL+ G +I+HLGMSG LRILP + Sbjct: 28 IRNGRLRWPVSDEIYRLSDTPVL-SVQRRAKYLLLELPDGWIIIHLGMSGSLRILPEALP 86 Query: 61 PQKHDHFDLEV-GGQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTARE 119 +KHDH DL + G+++R TDPRRFGA LW +G H +L LG EPL ++F Sbjct: 87 AEKHDHVDLVMSNGKILRYTDPRRFGAWLWTKELEG----HNVLAHLGPEPLSDEFNGEY 142 Query: 120 LFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQAI 179 L ++ + IK L+ +VVGVGNIYASESLF A IHP A +S + LA+ I Sbjct: 143 LQQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSTEECDLLARVI 202 Query: 180 RETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRSTF 239 + L +IEQGG++L+DF+ +G+ GYF Q VY R GE CR+C TPI K QR+TF Sbjct: 203 KAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATF 262 Query: 240 YCVSCQK 246 YC CQK Sbjct: 263 YCRHCQK 269 >XF0170 [L] COG0266 Formamidopyrimidine-DNA glycosylase Xfa Xylella fastidiosa 9a5c Length = 271 Score = 218 bits (556), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 114/247 (46%), Positives = 158/247 (63%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHG-TLIVHLGMSGHLRILPPGI 59 +R LRW P +E+ L G I + RR KYLLI + G +LI+HLGMSG LR+L P Sbjct: 28 LRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTLRLLAPET 87 Query: 60 APQKHDHFDLEVGGQ-VMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTAR 118 + HDH D+ + + V+R DPRRFG +LW + DG + H LL+ LG EPL + F Sbjct: 88 PLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQE--DGQI--HPLLQRLGCEPLSDSFNGD 143 Query: 119 ELFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQA 178 L++ +R R+ +K L+ IVVGVGNIYA+ESLF+A I P A KISL RY RLA+ Sbjct: 144 YLYQCSRARNVSVKTFLMDQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEV 203 Query: 179 IRETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRST 238 +++ L AI +GG++LRDF++ +G+ GYF+Q FVY R + C+ C + +RQ QR+T Sbjct: 204 VKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYGRQQQPCKQCGSLLRQTTIRQRTT 263 Query: 239 FYCVSCQ 245 +C CQ Sbjct: 264 VWCGHCQ 270 >XF0071 [L] COG0266 Formamidopyrimidine-DNA glycosylase Xfa Xylella fastidiosa 9a5c Length = 271 Score = 218 bits (556), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 114/247 (46%), Positives = 158/247 (63%), Gaps = 6/247 (2%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHG-TLIVHLGMSGHLRILPPGI 59 +R LRW P +E+ L G I + RR KYLLI + G +LI+HLGMSG LR+L P Sbjct: 28 LRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTLRLLAPET 87 Query: 60 APQKHDHFDLEVGGQ-VMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKFTAR 118 + HDH D+ + + V+R DPRRFG +LW + DG + H LL+ LG EPL + F Sbjct: 88 PLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQE--DGQI--HPLLQRLGCEPLSDSFNGD 143 Query: 119 ELFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQA 178 L++ +R R+ +K L+ IVVGVGNIYA+ESLF+A I P A KISL RY RLA+ Sbjct: 144 YLYQCSRARNVSVKTFLMDQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEV 203 Query: 179 IRETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRST 238 +++ L AI +GG++LRDF++ +G+ GYF+Q FVY R + C+ C + +RQ QR+T Sbjct: 204 VKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYGRQQQPCKQCGSLLRQTTIRQRTT 263 Query: 239 FYCVSCQ 245 +C CQ Sbjct: 264 VWCGHCQ 270 >YPO0052 [L] COG0266 Formamidopyrimidine-DNA glycosylase Ype Yersinia pestis Length = 269 Score = 218 bits (555), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 122/248 (49%), Positives = 153/248 (61%), Gaps = 10/248 (4%) Query: 1 MRHSGLRWPFPVGLEAL-LRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGI 59 +R++ LRWP V E L L + + S RR KYLL+ G +I+HLGMSG LR+L Sbjct: 28 VRNARLRWP--VSDEILTLSDQPVLSVQRRAKYLLLELPKGWIIIHLGMSGSLRVLSEET 85 Query: 60 APQKHDHFDLEV-GGQVMRMTDPRRFGAILW-HDLADGAVEEHLLLRSLGLEPLEEKFTA 117 A +KHDH DL V G+++R TDPRRFGA LW DL V HL G EPL ++FTA Sbjct: 86 AAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDLETSNVLAHL-----GPEPLSDEFTA 140 Query: 118 RELFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERLAQ 177 + LF ++R + IK L+ +VVGVGNIYASESLF A I P AAG ++ L Sbjct: 141 QYLFDKSRNKRTLIKPWLMDNKVVVGVGNIYASESLFAAGILPDRAAGSLTDAESVLLVA 200 Query: 178 AIRETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQRS 237 I+ L +IEQGG++LRDF+ +G+ GYF Q VY R GE CR C PI K GQRS Sbjct: 201 TIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRAGEPCRQCGHPIEIAKHGQRS 260 Query: 238 TFYCVSCQ 245 TF+C CQ Sbjct: 261 TFFCRHCQ 268 >NMB1295 [L] COG0266 Formamidopyrimidine-DNA glycosylase Nme Neisseria meningitidis MC58 Length = 275 Score = 216 bits (551), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 116/251 (46%), Positives = 148/251 (58%), Gaps = 8/251 (3%) Query: 1 MRHSGLRWPFPVGLEALLRGRVIRSTGRRGKYLLIHFDHGTLIVHLGMSGHLRILPPGIA 60 +R LRW L +L GR + S GRR KYLLI F G L++HLGMSG LRI P Sbjct: 28 LRQLKLRWQINPDLGEILSGRQVLSCGRRAKYLLIRFQTGVLLIHLGMSGSLRIFTPSDG 87 Query: 61 ----PQKHDHFDLEVG-GQVMRMTDPRRFGAILWHDLADGAVEEHLLLRSLGLEPLEEKF 115 P +HDH D+ G VMR DPR+FGAILW++ G E H LL LG EPL E F Sbjct: 88 RIGRPDRHDHVDIVFSDGTVMRYRDPRKFGAILWYE---GIEEHHPLLEKLGPEPLSEAF 144 Query: 116 TARELFRQTRGRSAPIKQVLLAGDIVVGVGNIYASESLFKARIHPKTAAGKISLPRYERL 175 A L+ + + + +K L+ +VVGVGNIYA+ESLF+A I P A ++ L Sbjct: 145 CADYLYARLKAQKRAVKLALMDNAVVVGVGNIYANESLFRAGISPHRPANRLKKKECALL 204 Query: 176 AQAIRETLAAAIEQGGSSLRDFIAVNGQSGYFQQNYFVYNRTGEACRICATPIRQIKQGQ 235 + ++ L AIE GGS+LRDF+ +G+SGYFQQ Y VY R + C C + + GQ Sbjct: 205 VETVKAVLQRAIETGGSTLRDFVDSDGKSGYFQQEYTVYGRHNQPCPRCGGLVVKETLGQ 264 Query: 236 RSTFYCVSCQK 246 R TFYC +CQK Sbjct: 265 RGTFYCPNCQK 275