BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0045.p (303 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM0040 [K] COG0583 Transcriptional regulator Sty Salmonella typ... 211 2e-54 nhaR [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 203 3e-52 ZnhaR [K] COG0583 Transcriptional regulator EcZ Escherichia coli... 202 8e-52 ECs0018 [K] COG0583 Transcriptional regulator Ecs Escherichia co... 202 8e-52 YPO0471 [K] COG0583 Transcriptional regulator Ype Yersinia pestis 191 2e-48 VC0677 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae 185 1e-46 VC1580 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae 130 3e-30 PM1283 [K] COG0583 Transcriptional regulator Pmu Pasteurella mul... 71 3e-12 PA1859 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 69 1e-11 PA3776 [K] COG0583 Transcriptional regulator Pae Pseudomonas aer... 67 3e-11 >STM0040 [K] COG0583 Transcriptional regulator Sty Salmonella typhimurium LT2 Length = 299 Score = 211 bits (537), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 112/292 (38%), Positives = 170/292 (58%), Gaps = 4/292 (1%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ +NY HL+YFW V K G V A+E L LT QTI+GQ+ EE L LF+R GR LE Sbjct: 3 MSHINYNHLYYFWHVYKEGSVVGAAEALFLTPQTITGQIKALEERLQGKLFKRKGRGLEP 62 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 ++ G +VF YA+++F++ +E+ + + R L VGVADA+ K + +L++A+ + Sbjct: 63 SELGELVFRYADKMFTLSQEMLDIVNYRKESNLL-FDVGVADALSKRLVSSVLDAAVVVD 121 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFATPELA 180 +PI + C E ++LL L+ HKLD+II+D P+ + +GEC SF+ T L Sbjct: 122 EPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVKIGECSVSFWCTNPLP 181 Query: 181 RRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGDAGA 240 K FP + L+PG + + +LL WF + ++ +I GEFDD AL+ AFG Sbjct: 182 ---EKAFPACLEERRLLVPGRRSMLGRKLLNWFNSQGLQVEILGEFDDAALMKAFGATHD 238 Query: 241 GIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRKLTHPAVLAIQSA 292 IF AP+ + ++EIGR E + E+++AI +R + HPAV I +A Sbjct: 239 AIFVAPSLYSLDFYADESVIEIGRVENVMEEYHAIFAERMIQHPAVQRICNA 290 >nhaR [K] COG0583 Transcriptional regulator Eco Escherichia coli K12 Length = 301 Score = 203 bits (517), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 113/292 (38%), Positives = 166/292 (56%), Gaps = 10/292 (3%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ +NY HL+YFW V K G V A+E L+LT QTI+GQ+ EE L LF+R GR LE Sbjct: 3 MSHINYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIRALEERLQGKLFKRKGRGLEP 62 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 ++ G +V+ YA+++F++ +E+ + + R L VGVADA+ K + +L +A+ Sbjct: 63 SELGELVYRYADKMFTLSQEMLDIVNYRKESNLL-FDVGVADALSKRLVSSVLNAAVVEG 121 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFAT---P 177 +PI + C E ++LL L+ HKLD+II+D P+ + +GEC SF+ T P Sbjct: 122 EPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVRIGECGVSFWCTNPPP 181 Query: 178 ELARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGD 237 E K FP + L+PG + + +LL WF + + +I GEFDD AL+ AFG Sbjct: 182 E------KPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKAFGA 235 Query: 238 AGAGIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRKLTHPAVLAI 289 IF AP A +VEIGR E + E+++AI +R + HPAV I Sbjct: 236 MHNAIFVAPTLYAYDFYADKTVVEIGRVENVMEEYHAIFAERMIQHPAVQRI 287 >ZnhaR [K] COG0583 Transcriptional regulator EcZ Escherichia coli O157:H7 EDL933 Length = 301 Score = 202 bits (514), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 112/292 (38%), Positives = 165/292 (56%), Gaps = 10/292 (3%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ +NY HL+YFW V K G V A+E L+LT QTI+GQ+ EE L LF+R GR LE Sbjct: 3 MSHINYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIRALEERLQGKLFKRKGRGLEP 62 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 ++ G +V+ YA+++F++ +E+ + + R L VGVAD + K + +L +A+ Sbjct: 63 SELGELVYRYADKMFTLSQEMLDIVNYRKESNLL-FDVGVADVLSKRLVSSVLNAAVVEG 121 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFAT---P 177 +PI + C E ++LL L+ HKLD+II+D P+ + +GEC SF+ T P Sbjct: 122 EPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVRIGECGVSFWCTNPPP 181 Query: 178 ELARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGD 237 E K FP + L+PG + + +LL WF + + +I GEFDD AL+ AFG Sbjct: 182 E------KPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKAFGA 235 Query: 238 AGAGIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRKLTHPAVLAI 289 IF AP A +VEIGR E + E+++AI +R + HPAV I Sbjct: 236 MHNAIFVAPTLYAYDFYADKTVVEIGRVENVMEEYHAIFAERMIQHPAVQRI 287 >ECs0018 [K] COG0583 Transcriptional regulator Ecs Escherichia coli O157:H7 Length = 301 Score = 202 bits (514), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 112/292 (38%), Positives = 165/292 (56%), Gaps = 10/292 (3%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ +NY HL+YFW V K G V A+E L+LT QTI+GQ+ EE L LF+R GR LE Sbjct: 3 MSHINYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIRALEERLQGKLFKRKGRGLEP 62 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 ++ G +V+ YA+++F++ +E+ + + R L VGVAD + K + +L +A+ Sbjct: 63 SELGELVYRYADKMFTLSQEMLDIVNYRKESNLL-FDVGVADVLSKRLVSSVLNAAVVEG 121 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFAT---P 177 +PI + C E ++LL L+ HKLD+II+D P+ + +GEC SF+ T P Sbjct: 122 EPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVRIGECGVSFWCTNPPP 181 Query: 178 ELARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGD 237 E K FP + L+PG + + +LL WF + + +I GEFDD AL+ AFG Sbjct: 182 E------KPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKAFGA 235 Query: 238 AGAGIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRKLTHPAVLAI 289 IF AP A +VEIGR E + E+++AI +R + HPAV I Sbjct: 236 MHNAIFVAPTLYAYDFYADKTVVEIGRVENVMEEYHAIFAERMIQHPAVQRI 287 >YPO0471 [K] COG0583 Transcriptional regulator Ype Yersinia pestis Length = 299 Score = 191 bits (485), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 106/290 (36%), Positives = 163/290 (56%), Gaps = 11/290 (3%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ +N+ HL+YFW V K G V A+E L LT QTI+GQ+ E LG LF+R GR L Sbjct: 3 MSHINFNHLYYFWQVCKEGSVVGAAEALFLTPQTITGQIKALEGRLGGKLFKRRGRGLVP 62 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 ++ G++VF YA+++F + +E+ + + R L VGVADA+ K + +LE+A+ Sbjct: 63 SELGQLVFRYADKMFMLSQEMLDIVNYRKESHLL-FDVGVADALSKRLVSQVLETAVVEH 121 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFA---TP 177 + I + C E ++LL L+ HKLD+I++D P+ + + LGEC SF+ P Sbjct: 122 EKIHLRCFESTHEMLLEQLSQHKLDMILSDCPVDSSQQEGLFSVKLGECSVSFYCRQPVP 181 Query: 178 ELARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGD 237 +L FP S L+PG + + +LL W + ++ ++ GEFDD AL+ AF Sbjct: 182 DLP------FPASLQQKRLLIPGRRSMLGRKLLNWINSKGLKVEVLGEFDDAALMNAFAV 235 Query: 238 AGAGIFAAPAAIAAQIR-KQYGLVEIGRTEAIREQFYAISVQRKLTHPAV 286 IF AP AA ++EIGR + ++E++Y I +R + HPAV Sbjct: 236 YHDAIFVAPTIYAADTYANDSEIIEIGRLDNVQEEYYVIFAERMIQHPAV 285 >VC0677 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae Length = 296 Score = 185 bits (469), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/300 (34%), Positives = 167/300 (55%), Gaps = 5/300 (1%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M+ LNY HL+YFW V K G V +A++ L LT QT++GQ+ E+ L L +R GR +E Sbjct: 1 MSHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEP 60 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 + G++VF YA+R+F + E+ + + L VGVADA+ K + +L +++ Sbjct: 61 TELGQLVFKYADRMFGLSYEMLDIVNYSQRSNLL-FDVGVADALSKRLVSKILLTSVPGD 119 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFATPELA 180 + I + C E ++LL LA HKLD+I++D P+ + + LGE SFF+ ++ Sbjct: 120 NRIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGLFSKKLGESRMSFFSFGDVD 179 Query: 181 RRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGDAGA 240 FP L+PG A+ ++ +WF+++ ++P I GEFDD AL+ AF + Sbjct: 180 ---FAPFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHS 236 Query: 241 -GIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRKLTHPAVLAIQSAARGNLIV 299 +F AP+ +++ + L IG + I+E++Y I +R + HPAV + A NL + Sbjct: 237 DAVFMAPSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL 296 >VC1580 [K] COG0583 Transcriptional regulator Vch Vibrio cholerae Length = 303 Score = 130 bits (328), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 86/280 (30%), Positives = 136/280 (48%), Gaps = 4/280 (1%) Query: 1 MAGLNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLEL 60 M LN+ HLHYFWTVAK G + RA+++L+++ +S Q+ E LG+ LF R GR L+L Sbjct: 14 MRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLGHDLFVRQGRSLQL 73 Query: 61 NDEGRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQ 120 + G +V +YAE IF++ EL + R QLR+G + + L L Sbjct: 74 TEVGHLVLEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRNFQENFLRPVLGKS 133 Query: 121 DPIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFATP-EL 179 D +R+I L+ LL L +HKLD+I+++ P+P + + + P + Sbjct: 134 D-VRLILSSSTLEDLLGQLQMHKLDLILSNRPVPSDSTQPWRCKRIAQQSVCLVGPPSDT 192 Query: 180 ARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIRPQITGEFDDGALLLAFGDAG 239 RRY+ FP L+PG + +R + + E+ + E DD A+L Sbjct: 193 LRRYQ--FPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDMAMLRLLARDV 250 Query: 240 AGIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQR 279 G+ P + + L G +A+ E FYAI+ +R Sbjct: 251 EGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKR 290 >PM1283 [K] COG0583 Transcriptional regulator Pmu Pasteurella multocida Length = 293 Score = 70.9 bits (172), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/292 (22%), Positives = 131/292 (44%), Gaps = 12/292 (4%) Query: 4 LNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLELNDE 63 +N+ +L F + +T A+ + + H++ T+S Q+ E+ +G LF R R++EL D Sbjct: 1 MNFTYLKLFLHLCETKNFAKTAAQNHMSPSTLSRQIQRMEQDVGQILFLRNNRQVELTDA 60 Query: 64 GRMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYL--LLESALAMQD 121 G + +A++ + +++++ LR + L + + +V A ++L +LE Sbjct: 61 GEKLLPFAQQSWMQWQQIKQQLR-DSAQQELNGELKLFCSVTAAYSHLPAILERFRTRYP 119 Query: 122 PIRIICREGKLDVLLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFATPEL-- 179 + I G + L + ++D+ +A P N+ H + + S A P + Sbjct: 120 KVEIQLTTGDPSLALQLVETQQVDLALAGQPK--NLPNHIAFHYIDDISLSLIA-PRIAC 176 Query: 180 -ARRYRKGFPGSFDGAPFLMPGEDAAVRPRLLRWFEKEKIR-PQITGEFDDGALLLAFGD 237 A + + P ++ PF++P E A R R+ +WF+++KI+ P+I ++ Sbjct: 177 SATQLLQQTPINWQQIPFILPVEGPA-RQRIDQWFKQQKIKHPKIYATVAGHEAIMPMVA 235 Query: 238 AGAGIFAAPAAIAAQIRKQYGLVEIGRTEAIREQFYAISVQRK-LTHPAVLA 288 G G+ P + + + I I VQ+K LT P V A Sbjct: 236 LGCGVAMLPDVVIKNSPMNSQVSILHLKTPITPFALGICVQKKSLTQPLVRA 287 >PA1859 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 295 Score = 68.9 bits (167), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 16/193 (8%) Query: 5 NYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLELNDEG 64 N L F +V +G ++ A+E++ LTA +S LS E LG L R RR+EL +EG Sbjct: 4 NSDELQSFVSVVDSGSISAAAEQMGLTASAVSRTLSRLEHKLGTTLLNRTTRRMELTEEG 63 Query: 65 RMVFDYAERIFSIGEELEEALRLRPGGRALQLRVGVADAVPKAIAYLLLESALAMQDPIR 124 R D A +I E LEE L LR A +LR+ A +L + + R Sbjct: 64 RYFLDQARQILQQMEALEERLALRRQSPAGRLRINAASP-------FMLHAVVPHIGEFR 116 Query: 125 IICREGKLDV----LLADLALHKLDIIIADSPMPPNVDVRGYHHLLGECDTSFFATPELA 180 + + +L++ L+ DL + D+ I + D + LG A+PE Sbjct: 117 RLYPDIQLELNTNDLIIDLLEQRTDVAIRIGALS---DSTLHARPLGASRLHILASPEYL 173 Query: 181 RRYRKGFPGSFDG 193 R+ G P S +G Sbjct: 174 ARH--GTPASIEG 184 >PA3776 [K] COG0583 Transcriptional regulator Pae Pseudomonas aeruginosa Length = 302 Score = 67.4 bits (163), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 50/142 (35%), Positives = 76/142 (53%), Gaps = 9/142 (6%) Query: 4 LNYKHLHYFWTVAKTGGVARASERLHLTAQTISGQLSLFEESLGYPLFRRVGRRLELNDE 63 ++ + LHYF + ++GG +RA+ERL + +S Q+ E+S+G PL RR R++EL Sbjct: 2 ISLRQLHYFVEIVESGGFSRAAERLFVAQSALSRQVRELEDSIGTPLLRRGPRQVELTPA 61 Query: 64 GRMVFDYAERIFSIGEELEEALRLR----PGGRALQLRVGVADAVPKAIAY-LLLESALA 118 GR A+R+ +LE A RL GG L LR+G + +VP L LA Sbjct: 62 GRAFLPRAQRLLG---DLEAARRLAREVGEGGHGL-LRLGHSSSVPLVGGLQAALRGYLA 117 Query: 119 MQDPIRIICREGKLDVLLADLA 140 +Q +R+ + + LADLA Sbjct: 118 VQSGVRLELTQQSSEQQLADLA 139