BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0031.p (789 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pa... 473 e-133 PAB1101 [R] COG1033 Predicted exporters of the RND superfamily P... 76 3e-13 PH0287 [R] COG1033 Predicted exporters of the RND superfamily Ph... 65 5e-10 TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tp... 63 3e-09 YPO2849 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pe... 62 5e-09 RSp1458 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 61 9e-09 >PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pae Pseudomonas aeruginosa Length = 793 Score = 473 bits (1218), Expect = e-133, Method: Compositional matrix adjust. Identities = 281/787 (35%), Positives = 441/787 (56%), Gaps = 18/787 (2%) Query: 13 LEALAFRARVAILLALLAFTALMAVFSLQLRMDAGFEKQIPSDHEYVATQHQYRDELFG- 71 LE L F R ++ + + + + Q+R FEK IP +H ++ ++R++L Sbjct: 15 LERLIFNNRPVVIFLCVLVSVFLFYQATQVRPSTSFEKMIPLEHPFIQKMLEHRNDLANL 74 Query: 72 ANRLNIVLRARHGSIWTKEGLTRLNAMTQAVMFLPNVNRLGVQSLWTPNTFVNEITEEGF 131 N + I + A +G I+TKE + L + V ++P V+R G++SLW+P+ E+TEEGF Sbjct: 75 GNTVRISVEAVNGDIFTKEYMETLRQIHDEVFYIPGVDRSGLKSLWSPSVRWTEVTEEGF 134 Query: 132 RADPVIAGTVTPESLTPEVIASIRDSANNGGFVGTLVSRKQDSAMIIAEINEFDANGK-- 189 VI T +P + +R++ G +G LV+ S+++ + E N K Sbjct: 135 AGGEVIPQTYDG---SPRALEELRNNVLKSGQIGRLVANNFKSSIVDVPLLEMYPNPKNQ 191 Query: 190 ----KVDYLAYNKLLND-LRAKYE--NGDFEVQIIGFAKQIGDVADGAQGVLKFCIMALL 242 K+DY ++ L + +R KY+ N + +V I+GFAK++GD+ DG V+ F + LL Sbjct: 192 SELIKLDYRQFSHELEEKIRDKYQLQNPNVKVHIVGFAKKVGDLIDGLVMVVGFFGICLL 251 Query: 243 LTALAVYWYCRSLPFTLLPIVCSLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFAIGVSHG 302 +T + +YW+ + + T+ ++ +LV+++WQ G L+L+G+GLDP ++LVPFL+FAIG+SHG Sbjct: 252 ITLVLLYWFTKCIRSTIAVLITTLVAVLWQLGLLNLVGFGLDPYSMLVPFLIFAIGISHG 311 Query: 303 VQQINYIVRGIAAGMGCEEAARASFRGLLVPGVLALVTAFVSFITLTLIPIPMVKELAIT 362 VQ+IN I + AAR +FR L +PG++A++ V FITL +I I +++ELAI Sbjct: 312 VQKINGIALQSSGADNALMAARLTFRQLFLPGMIAILADAVGFITLLVIDIGVIRELAIG 371 Query: 363 ASIGVGYKIITNLVMLPLAASLLKVNKAYADAAMRAQQKRARWLQVFARAAHPRNARVIV 422 ASIGV + TNL++LP+A S + ++K + + + ++ + + P+ A V + Sbjct: 372 ASIGVAVIVFTNLILLPVAISYIGISKKAVQRSKDDAVREHPFWRLLSNFSSPKVAPVSI 431 Query: 423 VVTLALFAASVWYSSDRLVGTLQAGAPELRADSRYNLDAKSISDNYDTGLDWLSVILATP 482 + L + +WY +G L GAPELR DSRYNLD I NY T D L V++ T Sbjct: 432 AIALLMLGGGLWYGKHLKIGDLDQGAPELRPDSRYNLDNDFIIRNYSTSSDVLVVMVKTS 491 Query: 483 ENSCDKVAFGRYQEQFDAAMRHVPGVMSVKKKKKKERERECGYNEGNPSMYSVPLDPANY 542 C ++ + + GV S ++ G NEGN ++ N Sbjct: 492 PEGCSTHQALAAMDELAWKLENTEGVQSAISMVTVSKQVIKGMNEGNLKWETL---SRNQ 548 Query: 543 AALAVEIGRVRGFLSKDCSMLATHLYLTDHKASTINGIIAAVKQYRAAHPLPGLTIRLAA 602 L I R G + DCS+ ++L DHKA T++ +AAV+ + A + L +LAA Sbjct: 549 DVLNNSIARADGLYNTDCSLAPLLVFLNDHKAETLDRAVAAVQAFAAENDKDDLQFQLAA 608 Query: 603 GNAGVIAAVNEEVEKSELPMMLYVYAAIIVLVFAVYRDLRAVVACCLPLTVATFIGYAFM 662 GNAG+ AA NE +++SEL +++ VY + + +R A + LPL + + +G A M Sbjct: 609 GNAGIEAATNEVIKQSELIILVLVYICVAAMCMITFRSFAATLCIVLPLILTSVLGNALM 668 Query: 663 KQLQIGLTVATLPVMVLAVGIGVDYAFYIYSRLQMHLAAGEAIAVALEKSIQEIGVATIF 722 L IG+ VATLPV+ L VGIGVDY YIY+RL+ L G + A ++++ G A +F Sbjct: 669 AALGIGVKVATLPVIALGVGIGVDYGIYIYTRLESFLRMGLPLQEAYYETLRSTGKAVLF 728 Query: 723 TAITLAIGVATWSFSQLKFQADMGKLLAFMFIVNLIMAMTALPAFAVVLERMFPRKGKIK 782 T + LAIGVATW FS +KFQADMG +L FM + N+ A+ LPA A L + P K + + Sbjct: 729 TGLCLAIGVATWIFSAIKFQADMGLMLTFMLLWNMFGALWLLPALARFL--INPAKLQAR 786 Query: 783 VNSMMNH 789 S+ H Sbjct: 787 KASLFAH 793 >PAB1101 [R] COG1033 Predicted exporters of the RND superfamily Pab Pyrococcus abyssi Length = 746 Score = 76.3 bits (186), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 168/783 (21%), Positives = 311/783 (39%), Gaps = 121/783 (15%) Query: 41 QLRMDAGFEKQIPSDHEYVATQHQYRDELFGANRLNIVLRARHGSIWTKEGLTRLNAMTQ 100 QLR + KQ+P D E V + ++E G+ Sbjct: 33 QLRFETDLSKQLPEDLEAVKSYFTLQNEFGGSG--------------------------S 66 Query: 101 AVMFLPNVNRLGVQSLWTPNTFVNEIT-EEGFRADPVIAGTVTPESLTPEVIASIRDSAN 159 A++++ N V + P + E+ R + T + L +++ + + + Sbjct: 67 ALIYVKIKNNDNVVDIRDPKIIEAMYSLEQRLREKEYVTDTFSIADLMVQILGRLPKNMD 126 Query: 160 NGGFV---------GTLVSRKQDSAMIIAEINEFDANGKKVDYLAYNKLLNDLRAKYENG 210 FV L+S S +II +N + N K A ++ ND+ + E Sbjct: 127 EVKFVLNMLPPEARNGLISGDYSSTIIIVNLNR-EKNQK-----ALVRVYNDIEREIERT 180 Query: 211 DF----EVQIIGFAKQIGDVADGAQGVLK--FCIMALLLTALAVYWYCRSLPFTLLPIVC 264 +F EV + G + + Q + I +++ + +Y+Y +S L+P+V Sbjct: 181 NFPQGVEVVLTGDLGITYKILEMLQNDMNRTMAISGIIVVLILLYFY-KSPIRMLVPLVP 239 Query: 265 SLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFAIGVSHGVQQIN--YIVRGIAAGMGCEEA 322 + +V G + LLG LD V ++ +G+ +GV N Y RG + Sbjct: 240 LIFGVVMTLGFMGLLGIPLDIATTTVGAMIIGMGIDYGVHVTNRYYEERGKGKSLEEAAE 299 Query: 323 ARASFRGLLVPGVLALVTAFVSFITLTLIPIPMVKELAITASIGVGYKIITNLVMLPLAA 382 + G + G A +T F+ L++ +P +K L+++ +G+G + +++ P A Sbjct: 300 EAIAETGKALLG--AALTTIAGFLALSISILPSLKRLSVSLVMGLGLAALNAVIVTPALA 357 Query: 383 SLLKVNKAYADAAMRAQQ---------KRARWLQVFARAAH--PRNARVI--VVVTLALF 429 L + + + M+ ++ K + + +A P A +I ++ ++L+ Sbjct: 358 IL---EEEFREKVMKKKEIIAIGGGKSKISFIFSMLGKAIKRSPWTALLIALIISGVSLY 414 Query: 430 AASVWYSSDRLVGTLQAGAPELRADSRYNLDAKSISDNYDTGLDWLSVILAT-----PEN 484 AS + RL + PE++A S I + G D +++++ P Sbjct: 415 GASKITTEVRLEKMIPTDLPEIQALS-------DIRSEFG-GQDEVTILIKADDVRDPTL 466 Query: 485 SCDKVAFGRYQEQFDAAMRHVPGVMSVKKKKKKERERECGYNEGNPSMYSVPLDPANYAA 544 D + F R + + D+ + +V S+ + + GY +P D + Sbjct: 467 VRDILRFER-EIKADSYINNVFETQSIADVVIQ----KYGY---------IPQDKEKISE 512 Query: 545 LAVEIGRVRGFLSKDCSMLATHLY--LTDHKASTINGIIAAVKQ--YRAAHPLPGLTIRL 600 A+E +S D SM L S N I+ ++ RA P PG+ + L Sbjct: 513 -AIE---GSSLVSSDYSMTIIKLKGNFMGVTQSEFNRIMEYFERAIQRADFP-PGVKVEL 567 Query: 601 AAG---NAGVIAAVNEEVEKSELPMMLYVYAAIIVLVFAVYRDLRAVVACCLPLTVATF- 656 A N + VNEE+ K L V +++VFA++R +A +P+ + Sbjct: 568 AGESYLNYVLNDLVNEELGKISTIGTLIV----VMVVFAIFRRPTVSIAMIMPMFLGALW 623 Query: 657 -IGYAFMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYSRLQMHLAAGEAIAVALEKSIQE 715 IGY + + T+A + M+ VG+GVDY +I R L G + +++ Sbjct: 624 TIGYMGLAGIPFSQTLAGVVSMI--VGLGVDYGMHITHRFLEELNEGNKTPII--TALES 679 Query: 716 IGVATIFTAITLAIGVATWSFSQLKFQADMGKLLAFMFIVNLIMAMTALPAFAVVLERMF 775 +G A+T A G +QL D G++LA ++ A PA +L+ F Sbjct: 680 VGPGIFVGALTTAGGFLALLSAQLTAIHDFGRVLAVGIFASMFAAYLVTPA---ILQLEF 736 Query: 776 PRK 778 RK Sbjct: 737 GRK 739 >PH0287 [R] COG1033 Predicted exporters of the RND superfamily Pho Pyrococcus horikoshii Length = 787 Score = 65.5 bits (158), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 145/673 (21%), Positives = 283/673 (42%), Gaps = 103/673 (15%) Query: 150 VIASIRDSANNGGFVGTLVSRKQDSAMIIAEINEFDANGKKVDYLAYNKLLNDLRAKYEN 209 V+ + + A NG LVSR S +II +N ++ + A ++ N+++ + E Sbjct: 172 VLNMLPEDARNG-----LVSRDYSSTIIIVSLN------REKNQRALVRVYNEIKNEIEK 220 Query: 210 GDF----EVQIIGFAKQIGDVADGAQGVLK--FCIMALLLTALAVYWYCRSLPFTLLPIV 263 +F EV + G + + Q + + +++ L +Y+Y +S L+P++ Sbjct: 221 SNFPEGVEVVLTGDLGITYKILEMLQNDMNRTMAVAGIIVIILLLYFY-KSPIRMLVPLI 279 Query: 264 CSLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFAIGVSHGVQQIN--YIVRGIAAGMGCEE 321 + + G + LLG LD V ++ +G+ +GV N Y R Sbjct: 280 PLIFGVTMTLGFMGLLGIPLDIATSTVGAMIIGMGIDYGVHVTNRYYEERNKGRSPEEAA 339 Query: 322 AARASFRGLLVPGVLALVTAFVSFITLTLIPIPMVKELAITASIGVGYKIITNLVMLPLA 381 S G + G A +T F+ L+L +P +K L+I+ +G+G + +++ P Sbjct: 340 EEAISETGKALLG--AALTTIAGFLALSLSILPSLKRLSISLVMGLGLAAVNAVIVTPAL 397 Query: 382 ASLLK------VNKAYADAAMRAQQKRARWLQVFARAA-----HPRNARVIVVVT--LAL 428 A L + + K ++ ++ + + +F+R P A +I V+ ++L Sbjct: 398 AILEEEFRTKILGKKGEIISIGGEEGKLGF--IFSRLGLFIKRSPWLALLIAVMISGVSL 455 Query: 429 FAASVWYSSDRLVGTLQAGAPELRA--DSRYNLDAKSISDNYDTGLDWLSVILAT----- 481 + A+ + RL + PE++A D R G D +++++ Sbjct: 456 YGATKITTEVRLEKMIPMDMPEIQALTDIRSEFG----------GQDEITILIKADDVRD 505 Query: 482 PENSCDKVAFGRYQEQFDAAMRHV---PGVMSVKKKK----KKERERECGYNEGNPSMYS 534 PE + F R + + D+ + +V + V +K +++E+ EG+ Sbjct: 506 PEIVRSILRFER-EVKADSYINNVFESESIADVVIEKYGYIPEDKEKIAKALEGS----- 559 Query: 535 VPLDPANYAALAVEI-GRVRGFLSKDCSMLATHLYLTDHKASTINGIIAAVKQYRAAHPL 593 L ++Y+ V++ G G +D + + + ++ + A+ Sbjct: 560 -SLVSSDYSLTIVKLKGNFMGVTQEDFNKIMEYFE----------------EELKRANFP 602 Query: 594 PGLTIRLAAG---NAGVIAAVNEEVEK-SELPMMLYVYAAIIVLVFAVYRDLRAVVACCL 649 PG+ LA N + VNEE+ K S + ++ ++++VFA++R VA + Sbjct: 603 PGVKAELAGESYLNYVLDNLVNEELGKISTIGTII-----VVLIVFAIFRRPTVAVAMIM 657 Query: 650 PLTVATF--IGYAFMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYSRLQMHLAAGEAIAV 707 P+ + IGY + + T+A + M+ VG+GVDY +I R L G + Sbjct: 658 PMFLGALWTIGYMGLAGIPFSQTLAGVVSMI--VGLGVDYGMHITHRFLEELKEGNKTPI 715 Query: 708 ALEKSIQEIGVATIFTAITLAIGVATWSFSQLKFQADMGKLLAFMFIVNLIMAMTALPAF 767 +++ +G + A+T A G +L D GK+LA +++ A PA Sbjct: 716 I--TAMESVGPGILIGALTTAGGFLALLTGRLTAIHDFGKVLAVGIFSSMLAAYLVTPA- 772 Query: 768 AVVLERMFPRKGK 780 +L+ F RK K Sbjct: 773 --ILQLEFGRKIK 783 >TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tpa Treponema pallidum Length = 888 Score = 62.8 bits (151), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 82/375 (21%), Positives = 164/375 (43%), Gaps = 23/375 (6%) Query: 18 FRARVAILLALL-AFTALMAVFSLQLRMDAGFEKQIPSDHEYVATQHQYRDELFGAN-RL 75 F A +L+A+L A T AV LR+D + IP ++ V Q D FG+ + Sbjct: 24 FYAHPWVLVAVLSALTLFFAVQLRTLRLDNNNFRFIPKENS-VRIADQRIDSTFGSQVPV 82 Query: 76 NIVLRARHGSIWTKEGLTRLNAMTQAVMFLPNVNRLGVQSLWTPNTFVNEITEEGFRADP 135 I ++ + S+ L + ++ + + +P V SL + G RA Sbjct: 83 LIGIKREYTSVVDPVFLADVRSLIERISAVPLVRAESTLSLLSAEYL-------GLRAGN 135 Query: 136 VIAGTVTPESLT---PEVIASIRDSANNGGFVGTLVSRKQDSAMIIAEINEFDANGKKVD 192 +I+ V P+ + EV R + + +LVSR S I+ ++ + + Sbjct: 136 IISERVVPDEFSGSAEEVQGVYRKLRDWDFYECSLVSRDLRSMQIVVFLDTSNEESSSPE 195 Query: 193 YLAYNKLLNDLRAKYENGDFEVQIIGFA--KQIGDVADGAQGVLKFCIMALLLTALAVYW 250 +A + + + +++ D + + G ++G+ A + + +L+ +A++ Sbjct: 196 AMAACRAIIRILGAWKSRDAQTFVTGVTVFNEMGNEA-STHDLTLLVPLVVLIIIVALFV 254 Query: 251 YCRSLPFTLLPIVCSLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFAIGVSHGVQQINYIV 310 R L LP++ ++S VW G + L L L+ ++P ++ A+G ++G+ ++ Sbjct: 255 SFRRLAGIFLPLLTVVISTVWALGAMALCAIPLSILSAILPVILIAVGSAYGIHIVSAYF 314 Query: 311 RGIAAGMGC----EEAAR--ASFRGLLVPGVLALVTAFVSFITLTLIPIPMVKELAITAS 364 G A+ C E AR + ++ P L+ +T FV F++ + + E + AS Sbjct: 315 YG-ASSRICSTRQEHRARIVEAVDKIIQPVFLSALTTFVGFVSFCFTSVVPIFEFGVFAS 373 Query: 365 IGVGYKIITNLVMLP 379 +GV L+++P Sbjct: 374 VGVASAFAVALMLIP 388 >YPO2849 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pestis Length = 1024 Score = 62.0 bits (149), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 84/332 (25%), Positives = 147/332 (44%), Gaps = 43/332 (12%) Query: 124 NEI-TEEGFRADPVIAGTVTPESL--TPEVIASIRDSANNGGFVGT----LVSRKQDSAM 176 +EI T EG+R V +P L VI S++D N G G LV ++ A Sbjct: 233 DEIKTAEGYRPLIVHYNNGSPVRLQDVANVIDSVQDVRNAGMSAGQPAVLLVISREPGAN 292 Query: 177 IIAEINEFDANGKKVDYLAYNKLLNDLRAKYENGDFEVQIIGFAKQIGDVADGAQGVLKF 236 IIA ++ A L LRA +Q+ + + V + Sbjct: 293 IIATVDRIRAE------------LPALRASIPA---SIQLNIAQDRSPTIRASLDEVERS 337 Query: 237 CIMALLLTALAVYWYCRSLPFTLLPIVCSLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFA 296 ++A+ L L V+ + RS TL+P V VSL+ F ++L G+ L+ L+++ + Sbjct: 338 LVIAVALVILVVFIFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATG 397 Query: 297 IGVSHGVQQINYIVRGIAAGMGCEEAARASFR--GLLVPGV-LALVTAFVSFITLTLIPI 353 V + + I R + AG+ + AA R G V + ++LV F+ + + +P Sbjct: 398 FVVDDAIVVLENISRHLEAGVKPKVAALRGVREVGFTVLSMSISLVAVFIPLLLMAGLPG 457 Query: 354 PMVKELAITASIGVGYKIITNLVMLP-LAASLLKVNKAYADAAMRAQQKRARWL------ 406 + +E A+T S+ +G ++ +L + P + A LL+ + + QQ+R R Sbjct: 458 RLFREFAVTLSVAIGISLVISLTLTPMMCAWLLRSHP-------KGQQQRIRGFGKVLLA 510 Query: 407 --QVFARAAH--PRNARVIVVVTLALFAASVW 434 Q + R+ + + R ++VV L+ A +VW Sbjct: 511 IQQGYGRSLNWALSHTRWVMVVLLSTIALNVW 542 >RSp1458 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1034 Score = 61.2 bits (147), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 99/214 (46%), Gaps = 6/214 (2%) Query: 199 LLNDLR---AKYENGDFEVQIIGFAKQIGDVADGAQGVLKFCIMALLLTALAVYWYCRSL 255 +L+D+R A + EV++ + + + D +G + I LL V+W+ R Sbjct: 295 VLHDVRKAIATFAESHPEVRLAEASNTVSPIEDNYEGSMSMLIEGALLAIAVVWWFLRDG 354 Query: 256 PFTLLPIVCSLVSLVWQFGTLHLLGYGLDPLAVLVPFLVFAIGVSHGVQQINYIVRGIAA 315 TL+ +S++ FG ++L GY L+ + +L LV I V + +I I R + Sbjct: 355 RATLVSAAALPLSIIPTFGAIYLAGYSLNTITLLALSLVVGILVDDAIVEIENIERHLRM 414 Query: 316 GMGCEEAA--RASFRGL-LVPGVLALVTAFVSFITLTLIPIPMVKELAITASIGVGYKII 372 G +AA A GL ++ ALV F+ ++ IP + ++ +TAS+ V ++ Sbjct: 415 GKTPYQAAMEAADEIGLAVIATTFALVAVFLPTAFMSGIPGLIFRQFGVTASVAVLMSLL 474 Query: 373 TNLVMLPLAASLLKVNKAYADAAMRAQQKRARWL 406 ++ P+ A+ L +A+ + RW+ Sbjct: 475 VARLLTPMMAAYLMKATRHAERDGPVMTRYLRWV 508