BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0006.p (943 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0312 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1265 0.0 AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 984 0.0 RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 976 0.0 PA4598 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 961 0.0 SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 956 0.0 acrF [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 860 0.0 NMA1969 [V] COG0841 Cation/multidrug efflux pump NmA Neisseria m... 854 0.0 STM3391 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 853 0.0 PA2018 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 852 0.0 NMB1715 [V] COG0841 Cation/multidrug efflux pump Nme Neisseria m... 852 0.0 >RSp0312 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1265 bits (3273), Expect = 0.0, Method: Compositional matrix adjust. Identities = 630/865 (72%), Positives = 741/865 (85%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 MP+FFI RP+FAWV+ALFI+L G IA+ +LPIARYPSVAPPTV+++ATYPGATPQTMNDG Sbjct: 1 MPQFFIRRPVFAWVIALFIILLGAIAIPKLPIARYPSVAPPTVNLSATYPGATPQTMNDG 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 VISLIERELS VKNLLYFESS+DTSG+A I TFKPGTDP +AQVDVQNKLKAIE RLPQ Sbjct: 61 VISLIERELSSVKNLLYFESSSDTSGSASIVATFKPGTDPAMAQVDVQNKLKAIEPRLPQ 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 VRQNG+TVESA+S FL+++ L S DGR+DE L+DY+ARN+VEELRR+EGVGRVQLFGA Sbjct: 121 VVRQNGLTVESASSGFLMIIGLQSDDGRFDETALSDYMARNVVEELRRIEGVGRVQLFGA 180 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 EQAMRIW+DP KL AYGL++ D+S AISQQNAQIAPG +G +PA+ Q++ +PLTVQGQL Sbjct: 181 EQAMRIWVDPAKLIAYGLSMNDLSAAISQQNAQIAPGSVGASPALPAQRVTVPLTVQGQL 240 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 +P QFAAIVL+A A+GS+V++GDVARVELGAQSY F NRENGK A AAVQL+PGANAV Sbjct: 241 TTPEQFAAIVLRANANGSKVVMGDVARVELGAQSYGFINRENGKAATAAAVQLAPGANAV 300 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 RTA +QARM EL ++P GM++S+P+NTAPFVKISI+KV+QTLIEAMVLVFLVMYLFLQ Sbjct: 301 RTAEGVQARMAELSRTMPAGMSYSIPFNTAPFVKISIEKVIQTLIEAMVLVFLVMYLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 NVRYT+IPAIVAPIALLGT +M +G+S+NVLTMFGMVLAIGIIVDDAIVVVENVER+M Sbjct: 361 NVRYTLIPAIVAPIALLGTFTIMLASGFSINVLTMFGMVLAIGIIVDDAIVVVENVERLM 420 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 A EGL PR+ATIKAM EITGA+IGITLVLTAVFIPMALA GSVGVIY+QF+++MAVSI+F Sbjct: 421 AQEGLSPRDATIKAMKEITGAVIGITLVLTAVFIPMALASGSVGVIYQQFTLSMAVSIVF 480 Query: 481 SAFLALSLTPALCATLLRPVPAGHHDKRGFFGAFNRAFNRLTARYESALGRLIARGLRMM 540 SAFLAL+LTPALCATLL+PV HH+KRG FG FNR F+R+T Y + +G+L+ R R+M Sbjct: 481 SAFLALTLTPALCATLLKPVDPAHHEKRGVFGWFNRRFDRITQGYAARVGKLVTRTGRVM 540 Query: 541 LVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGRE 600 LV+ A++ +L + + LPS+FLPEEDQGYFMT+FQLPADAT ERT V FER++ R Sbjct: 541 LVFGAIAAVLALAFRQLPSSFLPEEDQGYFMTTFQLPADATAERTLDVVKAFERHVASRA 600 Query: 601 DIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAAMESGVDGMVMSL 660 I +N+S++GFGFSGSG NAAMAFT LKDW R G+T+ E AQ AM +G VMSL Sbjct: 601 SIQSNMSIVGFGFSGSGSNAAMAFTMLKDWDARNGATAQNEMRLAQQAMAGATEGTVMSL 660 Query: 661 LPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLPAGASV 720 LPPAI+ELG SSGF +RLQDRANQG AALKAAE +LL LAA+S +SGVY DGLPAG S+ Sbjct: 661 LPPAIDELGTSSGFTLRLQDRANQGDAALKAAETKLLELAAQSRIVSGVYPDGLPAGTSI 720 Query: 721 QLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQLEDVM 780 +L+IDR KA ALGV+F+SIS+TLS A+GS YVNDFPNAGRMQQVI+QA A ARMQ++DV+ Sbjct: 721 RLDIDRQKAEALGVAFTSISETLSTAIGSLYVNDFPNAGRMQQVIIQADAPARMQIDDVL 780 Query: 781 KLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMAEMERL 840 KLYVRN GGMVPL+E+V+ W E P QL R+QGFPA RISG+AAPG +SG AMAEMERL Sbjct: 781 KLYVRNAGGGMVPLSEVVRPVWSETPLQLVRFQGFPAARISGNAAPGASSGAAMAEMERL 840 Query: 841 AQQLPPGFAVAWTGQSLQERLSGGQ 865 A QLPPGFA+AWTGQSLQER S Q Sbjct: 841 AAQLPPGFAIAWTGQSLQERQSAAQ 865 >AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1044 Score = 984 bits (2543), Expect = 0.0, Method: Compositional matrix adjust. Identities = 491/866 (56%), Positives = 639/866 (73%), Gaps = 1/866 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M RFFIDRPIFAWVVA+FI+L G++A+ LPIA+YP+VAPP +SI YPGA+P+ + Sbjct: 1 MARFFIDRPIFAWVVAIFIMLAGLLAIPMLPIAQYPNVAPPQISIGTNYPGASPEDIYQS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V IE EL+GV L+YFES++++SG I+VTF+PGT+ AQV+VQN++ +E RLP+ Sbjct: 61 VTRPIEEELNGVPGLIYFESTSESSGRISINVTFEPGTNIGEAQVEVQNRIARVEPRLPR 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 +V Q G+ VE A +SFL+MV+LTSVDG D + L DYL+RN++ ELRR+ GVG QLF Sbjct: 121 SVTQQGLRVEQAGTSFLMMVALTSVDGNTDAIGLGDYLSRNVLGELRRVPGVGSAQLFAT 180 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 +++MRIW+DP K+ LT D+ AI QN+Q+A GR+G +P GQQI+ + VQGQL Sbjct: 181 QRSMRIWMDPDKMLGLSLTSDDVINAIQAQNSQVAAGRIGASPNPVGQQISATVNVQGQL 240 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 SP +F +IVL+A DGS V L DVARVE+G +SY F++R NGKP+ VQLSP ANA+ Sbjct: 241 TSPEEFGSIVLRANPDGSSVRLRDVARVEVGGESYNFSSRLNGKPSAAIGVQLSPTANAM 300 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 +T+ ++A MEEL PQG+ + +PY+T+PFVKISI+KV+ TLIEAM+LVF+VM++FLQ Sbjct: 301 QTSEGVRATMEELSRYFPQGIEYEIPYDTSPFVKISIEKVIHTLIEAMILVFVVMFVFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+RYT+IP +V P+ALLGT AVM ++G+S+NVLTMF MVLAIGI+VDDAIVVVENVERIM Sbjct: 361 NIRYTIIPTLVVPVALLGTCAVMYVSGFSINVLTMFAMVLAIGILVDDAIVVVENVERIM 420 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 A E L P+EAT KAMG+I+GAIIGITLVLTAVF+PMA G+VG+IY+QFS+ M VSILF Sbjct: 421 AEEHLSPKEATRKAMGQISGAIIGITLVLTAVFVPMAFFPGAVGIIYQQFSLTMVVSILF 480 Query: 481 SAFLALSLTPALCATLLRPVPAGHHDKRGFFGAFNRAFNRLTARYESALGRLIARGLRMM 540 S FLALSLTPALCA+ L+P+ AGHH+K+GFFG FNR F++ + +Y S++G +I R R M Sbjct: 481 SGFLALSLTPALCASFLKPIKAGHHEKKGFFGWFNRNFDKASHKYSSSVGGIIKRSGRFM 540 Query: 541 LVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGRE 600 ++YAAL L LPS+FLP EDQGY + Q PA+A+TERT +++ Q E+ Sbjct: 541 IIYAALLAGLGWAYMQLPSSFLPNEDQGYLIVDIQAPAEASTERTLQSIQQIEKIFMEEP 600 Query: 601 DIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAAMESGV-DGMVMS 659 + +++ GF FSGSG NA +AF LKDW ER SAA A G+ D M + Sbjct: 601 AVERVIAISGFSFSGSGQNAGLAFATLKDWSERGPEDSAAAISARINGKLWGLPDAMSFA 660 Query: 660 LLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLPAGAS 719 L PP I+ LGNSSGF RLQDR+ G AL AA AQL+A A +S L+G+ +G+P A Sbjct: 661 LSPPPIQGLGNSSGFTFRLQDRSGAGQTALSAAGAQLMAAARQSPVLAGLRIEGMPDAAQ 720 Query: 720 VQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQLEDV 779 V L IDR KA GV+FS I+ T+SA MGS YVNDFPNAGRMQ+V +QA+ RM+ ED+ Sbjct: 721 VNLIIDREKANTFGVTFSDINATISANMGSSYVNDFPNAGRMQRVTVQAEQGQRMKTEDL 780 Query: 780 MKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMAEMER 839 + L VRN +GGMVP++ W P+Q+ Y G+PA+R+SG +APG +SG+A+AEMER Sbjct: 781 LNLNVRNANGGMVPVSSFATVEWVRGPSQVVGYNGYPAIRVSGQSAPGYSSGDAIAEMER 840 Query: 840 LAQQLPPGFAVAWTGQSLQERLSGGQ 865 LA++LP GF WTGQSLQE SG Q Sbjct: 841 LARELPGGFGFEWTGQSLQEIQSGSQ 866 >RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 976 bits (2523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/870 (55%), Positives = 627/870 (72%), Gaps = 6/870 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M +FFIDRP+FAWV+ALFI++ G I+++QLPIA+YP++APP++ I ATYPGA+ +T++D Sbjct: 1 MAKFFIDRPVFAWVLALFIIVAGAISITQLPIAQYPTIAPPSIIITATYPGASAKTLDDA 60 Query: 61 VISLIERELSGVKNLLYFES-SADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLP 119 V S+IE+E++G LLY ES S +G A I+VTFKPGTDP LAQVDVQN+LK +EARLP Sbjct: 61 VTSIIEQEMNGADGLLYIESVSQAGNGQATITVTFKPGTDPALAQVDVQNRLKRVEARLP 120 Query: 120 QTVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFG 179 +V Q GV V+ S+FLL +L S DG+ D V L DY++RN++ E++R+ GVG+ LFG Sbjct: 121 SSVTQQGVQVDKTRSNFLLFATLISKDGKMDPVALGDYISRNVLNEVKRVPGVGQAVLFG 180 Query: 180 AEQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQ 239 E+AMRIWIDP KL Y LT TD+ AI QNA ++ G LGD P+ Q IA + V+GQ Sbjct: 181 TERAMRIWIDPAKLVGYKLTPTDVYNAIRNQNALVSAGTLGDLPSTSDQPIAATVVVEGQ 240 Query: 240 LQSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANA 299 + + QF IVL +K DGS+V + DVAR+ELG Q+YA + R NG+P VQLSP NA Sbjct: 241 MTTTEQFGNIVLVSKPDGSQVRIKDVARLELGGQTYATSARINGQPISAIGVQLSPTGNA 300 Query: 300 VRTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFL 359 + TA A++A+++EL P G+ + +PY+T+ FV+ISI++VV+TL EAM LVFLVM +FL Sbjct: 301 LGTAKAVKAKLDELSKYFPAGVEYKIPYDTSKFVQISIEEVVKTLFEAMALVFLVMLVFL 360 Query: 360 QNVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERI 419 QN+RYT+IP+IV PI+LLG A M G+S+NVLTMFG+VLAIGI+VDDAIVVVENVERI Sbjct: 361 QNIRYTLIPSIVVPISLLGAFATMNALGFSINVLTMFGLVLAIGILVDDAIVVVENVERI 420 Query: 420 MAHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSIL 479 M+ EGL PREAT KAMG+ITGAIIGITLVL AVFIPMA GSVG IYRQFS++M SI Sbjct: 421 MSQEGLPPREATRKAMGQITGAIIGITLVLMAVFIPMAFFSGSVGAIYRQFSLSMVASIF 480 Query: 480 FSAFLALSLTPALCATLLRPVPAG-HHDKRGFFGAFNRAFNRLTARYESALGRLIARGLR 538 FSA +AL+LTPALC+TLL+P+ G HH+K+GFFG FNR F T RY+S + R++ + R Sbjct: 481 FSALMALTLTPALCSTLLKPIEKGSHHEKKGFFGWFNRMFTSTTDRYQSLVERVLKKTFR 540 Query: 539 MMLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKG 598 M++Y AL +V LPS+FLP EDQGY +T+ QLP A+ RT + E Y + Sbjct: 541 YMVIYGALIAAVVFLFMRLPSSFLPNEDQGYIITNIQLPPAASANRTLEVIKHVENYYQH 600 Query: 599 REDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQA--AMESGV-DG 655 + + ++V GF FSG+GPNAA+ FT LKDW R G+ +A+A+A +A A+ G+ D Sbjct: 601 EKAVENIVAVQGFSFSGNGPNAALVFTTLKDWSSR-GADQSADAVAGRAFGALFGGIRDA 659 Query: 656 MVMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLP 715 +V L PP I ELGN++GF RLQDR G+ AL AA QLL +A +S L V DGL Sbjct: 660 IVFPLNPPPIPELGNATGFTFRLQDRGGLGHDALMAARNQLLGMAGQSKVLKNVRPDGLE 719 Query: 716 AGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQ 775 Q++IDR KA ALGV+F+ I++ LS A+GS Y NDFPN GR Q+VI+QA RMQ Sbjct: 720 DSPQYQVDIDREKANALGVAFADINNVLSTALGSAYANDFPNYGRQQRVIVQADRINRMQ 779 Query: 776 LEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMA 835 ED+M LYVRN G MVP++ K W P QL RY G+P+VRISG AA G ++G+AM Sbjct: 780 PEDIMNLYVRNTQGSMVPMSAFAKGHWVVGPVQLVRYNGYPSVRISGDAATGASTGDAMD 839 Query: 836 EMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 EME LA +LP G WTGQSLQE+ SG Q Sbjct: 840 EMEHLASRLPAGIGFEWTGQSLQEKSSGSQ 869 >PA4598 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1043 Score = 961 bits (2484), Expect = 0.0, Method: Compositional matrix adjust. Identities = 483/870 (55%), Positives = 615/870 (70%), Gaps = 7/870 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M FFI RP FAWVVALFI L G++ +S+LP+A+YP+VAPP ++I ATYPGA+ + + D Sbjct: 1 MSEFFIKRPNFAWVVALFISLAGLLVISKLPVAQYPNVAPPQITITATYPGASAKVLVDS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V S++E L+G K LLYFES+ +++GTA+I VTF+PGTDP+LAQVDVQN+LK EAR+PQ Sbjct: 61 VTSVLEESLNGAKGLLYFESTNNSNGTAEIVVTFEPGTDPDLAQVDVQNRLKKAEARMPQ 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDG--RYDEVRLNDYLARNIVEELRRMEGVGRVQLF 178 V G+ VE ++ FLL+ +L+ +G R D L DY ARNI ELRR+ GVG++Q F Sbjct: 121 AVLTQGLQVEQTSAGFLLIYALSYKEGAQRSDTTALGDYAARNINNELRRLPGVGKLQFF 180 Query: 179 GAEQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQG 238 +E AMR+WIDP KL +GL++ D+S AI QN Q+ G G AP Q++ L V+G Sbjct: 181 SSEAAMRVWIDPQKLVGFGLSIDDVSNAIRGQNVQVPAGAFGSAPGSSAQELTATLAVKG 240 Query: 239 QLQSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGAN 298 L P +F +VL+A DGS V L DVAR+ELG +SY ++R NG P A+QLSPGAN Sbjct: 241 TLDDPQEFGQVVLRANEDGSLVRLADVARLELGKESYNISSRLNGTPTVGGAIQLSPGAN 300 Query: 299 AVRTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLF 358 A++TA ++ R+ EL P+ M +S+PY+T+ FV ++I+KV+ TLIEAMVLVFLVM+LF Sbjct: 301 AIQTATLVKQRLAELSAFFPEDMQYSVPYDTSRFVDVAIEKVIHTLIEAMVLVFLVMFLF 360 Query: 359 LQNVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVER 418 LQNVRYT+IP+IV P+ LLGTL VM L G+SVN++TMFGMVLAIGI+VDDAIVVVENVER Sbjct: 361 LQNVRYTLIPSIVVPVCLLGTLMVMYLLGFSVNMMTMFGMVLAIGILVDDAIVVVENVER 420 Query: 419 IMAHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSI 478 IMA EG+ P EAT+KAM +++GAI+GITLVL+AVF+P+A GSVGVIY+QFSV++AVSI Sbjct: 421 IMAEEGISPAEATVKAMKQVSGAIVGITLVLSAVFLPLAFMAGSVGVIYQQFSVSLAVSI 480 Query: 479 LFSAFLALSLTPALCATLLRPVPAGHHDKRGFFGAFNRAFNRLTARYESALGRLIARGLR 538 LFS FLAL+ TPALCATLL+P+P GHH+KRGFFGAFNR F R+T RY +L+AR R Sbjct: 481 LFSGFLALTFTPALCATLLKPIPEGHHEKRGFFGAFNRGFARVTERYSLLNSKLVARAGR 540 Query: 539 MMLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKG 598 MLVYA L +L LP AF+P ED GY + QLP A+ RT ++ ER+LK Sbjct: 541 FMLVYAGLVAMLGYFYLRLPEAFVPAEDLGYMVVDVQLPPGASRVRTDATGEELERFLKS 600 Query: 599 REDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAA---QAAMESGVDG 655 RE + + + GF FSG G NAA+AF KDW ER SAA +AA A+ DG Sbjct: 601 REAVASVFLISGFSFSGQGDNAALAFPTFKDWSERGAEQSAAAEIAALNEHFALPD--DG 658 Query: 656 MVMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLP 715 VM++ PP I LGNS GFA+RL DR+ G AL A LL + K +GL Sbjct: 659 TVMAVSPPPINGLGNSGGFALRLMDRSGVGREALLQARDTLLGEIQTNPKFLYAMMEGLA 718 Query: 716 AGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQ 775 ++L IDR KA ALGVSF +IS TLSAA GS +NDF NAGR Q+V++QA+ RM Sbjct: 719 EAPQLRLLIDREKARALGVSFETISGTLSAAFGSEVINDFTNAGRQQRVVIQAEQGNRMT 778 Query: 776 LEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMA 835 E V++LYV N +G +VPL+ V W E P QL RY G+P++RI G AAPG ++GEAMA Sbjct: 779 PESVLELYVPNAAGNLVPLSAFVSVKWEEGPVQLVRYNGYPSIRIVGDAAPGFSTGEAMA 838 Query: 836 EMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 EMERLA QLP G WTG S QE++S GQ Sbjct: 839 EMERLASQLPAGIGYEWTGLSYQEKVSAGQ 868 >SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1048 Score = 956 bits (2471), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/868 (56%), Positives = 625/868 (72%), Gaps = 4/868 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 MP FFIDRPIFAWVVA+FI++ G+IA+ LP+++YP VAPP +SIN YPGA+ Q Sbjct: 1 MPSFFIDRPIFAWVVAIFIMIAGIIAIPLLPVSQYPDVAPPQISINTNYPGASSQDTYQS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V LIE EL+GV+ LLYFESS +SG+ I TF+PGTDP A VD+QN+++ +E RLP Sbjct: 61 VTRLIEDELNGVEGLLYFESSTSSSGSVSIDATFQPGTDPSQASVDIQNRVQRVEPRLPD 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 VRQ GV V+ A + FLL++SLTS DG D + L DYL+RN++ E++R+ GVGR QLF Sbjct: 121 PVRQQGVQVDEAGAGFLLIISLTSTDGSMDAIGLGDYLSRNVLSEIQRVPGVGRAQLFAT 180 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 E++MR+W+DP K+ LT D++ AI QNAQIA G +G P QQ+ P+ ++GQL Sbjct: 181 ERSMRVWLDPDKMLGLNLTAADVTAAIQAQNAQIASGSIGAQPNPITQQVTAPVVIKGQL 240 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 SP +F AIVL+A ADGS V L DVAR+E+G +SY F+ R NG P+ AVQLSP NA+ Sbjct: 241 SSPEEFGAIVLRANADGSAVRLRDVARLEIGGESYTFSTRLNGSPSAAIAVQLSPSGNAM 300 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 T+AAI+ARM+EL P+G+ +S+PY+T+PFV +SI+KV+ TL+EA+ LVFLVM+LFLQ Sbjct: 301 STSAAIKARMDELAEFFPEGLEYSIPYDTSPFVAVSIEKVLHTLVEAVGLVFLVMFLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 NVRYT+IP IV P+ALLGT AVM G+S+NVLTMFGMVLAIGI+VDDAI+VVENVERIM Sbjct: 361 NVRYTIIPTIVVPVALLGTCAVMLAMGFSINVLTMFGMVLAIGILVDDAIIVVENVERIM 420 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 + EGL P++AT KAM +ITGA+IGITLVL +VFIPMA G+VGVIYRQFS+ M VSILF Sbjct: 421 SEEGLTPKDATRKAMKQITGAVIGITLVLASVFIPMAFFPGAVGVIYRQFSLTMVVSILF 480 Query: 481 SAFLALSLTPALCATLLRPVPAGHHD-KRGFFGAFNRAFNRLTARYESALGRLIARGLRM 539 SA LALSLTPALCA+ L+ VP GHH KRGFFG FNR F+R + Y A+G ++ R R Sbjct: 481 SALLALSLTPALCASFLKQVPKGHHHAKRGFFGWFNRGFDRTSHGYTRAVGGIVRRTGRF 540 Query: 540 MLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGR 599 M++Y AL L LPS+FLP+EDQG+ + QLP++AT RT ++Q E Sbjct: 541 MVIYLALLAGLGWAFLQLPSSFLPDEDQGFVIVMMQLPSEATANRTTEVIEQTETIFGQE 600 Query: 600 EDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQA--AMESGVDGMV 657 + + +++ GF F GSG NA +AF LKDW ER S A+++A +A AM D + Sbjct: 601 KAVDTIVAINGFSFFGSGQNAGLAFVTLKDWSERDADNS-AQSIAGRATMAMSQIKDAIS 659 Query: 658 MSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLPAG 717 +L PPAI+ LG + GF+ RLQDRA G AAL A QLL LA++S L+GV +G+P Sbjct: 660 FALSPPAIQGLGTTGGFSFRLQDRAGLGQAALAEARDQLLDLASQSKVLTGVRFEGMPDA 719 Query: 718 ASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQLE 777 A V + IDR KA GV+F+ I+ T+S +GS YVNDFPNAGRMQ+V +QA + RMQ Sbjct: 720 AQVSVNIDREKANTFGVTFADINSTISTNLGSSYVNDFPNAGRMQRVTVQADETKRMQTA 779 Query: 778 DVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMAEM 837 D++ L VRN +GGMVPL+ W +APTQ Y G+PAVRISG AAPG +SG+A+AEM Sbjct: 780 DLLNLNVRNSNGGMVPLSAFADVEWVKAPTQTVGYNGYPAVRISGEAAPGYSSGDAIAEM 839 Query: 838 ERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 ERL +LP GF WTGQSLQE SG Q Sbjct: 840 ERLVAELPAGFGYEWTGQSLQEIQSGSQ 867 >acrF [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1034 Score = 860 bits (2223), Expect = 0.0, Method: Compositional matrix adjust. Identities = 435/871 (49%), Positives = 596/871 (68%), Gaps = 6/871 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M FFI RPIFAWV+A+ +++ G +A+ QLP+A+YP++APP VS++A YPGA QT+ D Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V +IE+ ++G+ NL+Y S++D++G+ I++TF+ GTDP++AQV VQNKL+ LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 V+Q G++VE ++SS+L++ S + + ++DY+A N+ + L R+ GVG VQLFGA Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 + AMRIW+D LN Y LT D+ + QN QIA G+LG PA+ GQQ+ + Q + Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 ++P +F + L+ +DGS V L DVARVELG ++Y R NGKPA ++L+ GANA+ Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 TA AI+A++ EL+P PQGM PY+T PFV++SI +VV+TL EA++LVFLVMYLFLQ Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+R T+IP I P+ LLGT A++ GYS+N LTMFGMVLAIG++VDDAIVVVENVER+M Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 + L P+EAT K+M +I GA++GI +VL+AVFIPMA GGS G IYRQFS+ + ++ Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SAFLALSLTPALCATLLRPVPAGHHDKR-GFFGAFNRAFNRLTARYESALGRLIARGLRM 539 S +AL LTPALCATLL+PV A HH+ + GFFG FN F+ Y +++G+++ R Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540 Query: 540 MLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQF-ERYLKG 598 +L+YA + +VV LPS+FLPEEDQG F+T QLPA AT ERT + +DQ + YLK Sbjct: 541 LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600 Query: 599 -REDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAAMESGV--DG 655 + ++ + +V GF FSG NA MAF LK W+ER G ++AEA+ +A ME G DG Sbjct: 601 EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660 Query: 656 MVMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKS-GKLSGVYSDGL 714 V+ PAI ELG ++GF L D+A G+ AL A QLL +AA+ L V +GL Sbjct: 661 FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720 Query: 715 PAGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARM 774 A +LE+D+ KA ALGVS S I+ T+S A+G YVNDF + GR++++ +QA A RM Sbjct: 721 EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780 Query: 775 QLEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAM 834 EDV KLYVR+ +G MVP + + W +L+RY G P++ I G AAPG +SG+AM Sbjct: 781 LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840 Query: 835 AEMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 A ME LA +LP G WTG S QERLSG Q Sbjct: 841 ALMENLASKLPAGIGYDWTGMSYQERLSGNQ 871 >NMA1969 [V] COG0841 Cation/multidrug efflux pump NmA Neisseria meningitidis Z2491 Length = 1067 Score = 854 bits (2206), Expect = 0.0, Method: Compositional matrix adjust. Identities = 443/871 (50%), Positives = 604/871 (69%), Gaps = 8/871 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M +FFIDRPIFAWV+++FI+ G+ + LP+++YPSVA PT++++ATYPGA+ Q M D Sbjct: 1 MAKFFIDRPIFAWVISIFIIAAGIFGIKSLPVSQYPSVAAPTITLHATYPGASAQVMEDS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V+S+IER ++GV+ L Y +SAD+SG+ +S+TF P TD LAQV+VQNKL + + LP Sbjct: 61 VLSVIERNMNGVEGLDYMSTSADSSGSGSVSLTFTPDTDENLAQVEVQNKLSEVLSTLPA 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 TV+Q GVTV A S+FL++V L+S D + E +NDY RNIV EL+R+EGVG+V+LFGA Sbjct: 121 TVQQYGVTVSKARSNFLMIVMLSS-DVQSTE-EMNDYAQRNIVPELQRIEGVGQVRLFGA 178 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 ++AMRIW+DP KL Y L+ D+ +A+S QN QI+ G +G PAVRGQ + +T QGQL Sbjct: 179 QRAMRIWVDPKKLQNYNLSFADVGSALSAQNVQISAGSIGSLPAVRGQTVTATVTAQGQL 238 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 + +F ++L+A DGS V L DVARV LG + Y+ + R NG AV LS NA+ Sbjct: 239 GTAEEFGNVILRANTDGSNVYLKDVARVGLGMEDYSSSTRLNGVNTTGMAVMLSNSGNAM 298 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 TA A++ RM L PQGM++ PY+T+ FV+ISI+KV+ TLIEAMVLVF+VMYLFLQ Sbjct: 299 ATAKAVKERMATLEKYFPQGMSWKTPYDTSKFVEISIEKVIHTLIEAMVLVFVVMYLFLQ 358 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+RYT+IP IV PI+LLG A + G S+NVLTMF MVL IGI+VDDAIVVVENVERIM Sbjct: 359 NIRYTLIPTIVVPISLLGGFAFISYMGMSINVLTMFAMVLVIGIVVDDAIVVVENVERIM 418 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 A EGL P+EAT KAMG+I+GA+IGIT VL +VF+P+A+ G+ G IY+QF++ MA SI F Sbjct: 419 ADEGLPPKEATKKAMGQISGAVIGITAVLISVFVPLAMFSGATGNIYKQFALTMASSIAF 478 Query: 481 SAFLALSLTPALCATLLRPVPAGHH-DKRGFFGAFNRAFNRLTARYESALGRLIARGLRM 539 SAFLAL+LTPALCAT+L+ +P GHH +K+GFFG FN+ FN T YE + +++ + RM Sbjct: 479 SAFLALTLTPALCATMLKTIPKGHHEEKKGFFGWFNKKFNSWTHGYEGRVAKVLRKTFRM 538 Query: 540 MLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGR 599 M+VY L+ + V LP++FLP EDQG+ M S QLPA AT ERT + Q + K Sbjct: 539 MVVYIGLAVVGVFLFMRLPTSFLPTEDQGFVMVSVQLPAGATQERTNATLAQVTQLAKSI 598 Query: 600 EDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAA---MESGVDGM 656 +I ++V GF FSGSG N AM F LKDW ER S A A+A + M + DG Sbjct: 599 PEIENIITVSGFSFSGSGQNMAMGFAILKDWNERTAPGSDAVAIAGKLTGMMMGTLKDGF 658 Query: 657 VMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKL--SGVYSDGL 714 ++++PP I ELGN SG ++ LQDR N G+ AL A +L+ SG S V + GL Sbjct: 659 GIAVVPPPILELGNGSGLSINLQDRNNTGHTALLAKRNELIQKMRASGLFDPSTVRAGGL 718 Query: 715 PAGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARM 774 ++++I+R AAA G+SF+ I L++A+ S YV+DFPN GR+Q+V++QA ARM Sbjct: 719 EDSPQLKIDINRAAAAAQGISFADIRTALASALSSSYVSDFPNQGRLQRVMVQADEDARM 778 Query: 775 QLEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAM 834 Q D++ L V N+SG VPL+ + SW Q R+ G+P++++S S A GV++G+AM Sbjct: 779 QPADILNLTVPNKSGVAVPLSTIATVSWENGTEQSVRFNGYPSMKLSASPATGVSTGQAM 838 Query: 835 AEMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 A ++++ +L G+++ W GQS +E G Q Sbjct: 839 AAVQKMVDELGGGYSLEWGGQSREEAKGGSQ 869 >STM3391 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1037 Score = 853 bits (2203), Expect = 0.0, Method: Compositional matrix adjust. Identities = 433/875 (49%), Positives = 589/875 (67%), Gaps = 14/875 (1%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M FFI RPIFAWV+A+ +++ G +A+ QLP+A+YP++APP VSI+ATYPGA QT+ D Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAIMQLPVAQYPTIAPPAVSISATYPGADAQTVQDT 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V +IE+ ++G+ NL+Y S++D++G+ I++TF+ GTDP++AQV VQNKL+ LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 V+Q G++VE ++SSFL++ S + + ++DY+A NI + + R+ GVG VQLFGA Sbjct: 121 EVQQQGISVEKSSSSFLMVAGFVSDNPNTTQDDISDYVASNIKDSISRLNGVGDVQLFGA 180 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 + AMRIW+D LN Y LT D+ + QN QIA G+LG PA+ GQQ+ + Q +L Sbjct: 181 QYAMRIWLDANLLNKYQLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRL 240 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 + P +F + L+ DGS V L DVAR+ELG ++Y R NGKPA ++L+ GANA+ Sbjct: 241 KDPEEFGKVTLRVNTDGSVVHLKDVARIELGGENYNVVARINGKPASGLGIKLATGANAL 300 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 TA AI+ ++ EL+P PQGM PY+T PFVKISI +VV+TL EA++LVFLVMYLFLQ Sbjct: 301 DTATAIKVKLAELQPFFPQGMKVVYPYDTTPFVKISIHEVVKTLFEAIILVFLVMYLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+R T+IP I P+ LLGT AV+ GYS+N LTMFGMVLAIG++VDDAIVVVENVER+M Sbjct: 361 NIRATLIPTIAVPVVLLGTFAVLAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 + L PREAT K+M +I GA++GI +VL+AVFIPMA GGS G IYRQFS+ + ++ Sbjct: 421 MEDNLSPREATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SAFLALSLTPALCATLLRPVPAGHHDKR-GFFGAFNRAFNRLTARYESALGRLIARGLRM 539 S +AL LTPALCATLL+PV A HH+K+ GFFG FN F+ Y +++ ++ R Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHEKKSGFFGWFNTRFDHSVNHYTNSVSGIVRNTGRY 540 Query: 540 MLVYAALSGLLVVGMQA----LPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERY 595 +++Y L+VVGM LP++FLPEEDQG F+T QLP+ AT ERT + +DQ Y Sbjct: 541 LIIYL----LIVVGMAVLFLRLPTSFLPEEDQGVFLTMIQLPSGATQERTQKVLDQVTHY 596 Query: 596 LKGRE--DIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQA--AMES 651 E ++ + +V GF FSG G N+ MAF LK W+ER G ++ EA+ A+A A Sbjct: 597 YLNNEKANVESVFTVNGFSFSGQGQNSGMAFVSLKPWEERNGEENSVEAVIARATRAFSQ 656 Query: 652 GVDGMVMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGK-LSGVY 710 DG+V PAI ELG ++GF L D+ G+ AL A QLL + AK L V Sbjct: 657 IRDGLVFPFNMPAIVELGTATGFDFELIDQGGLGHDALTKARNQLLGMVAKHPDLLVRVR 716 Query: 711 SDGLPAGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQA 770 +GL +L++D+ KA ALGVS S I++T+SAA+G +YVNDF + GR+++V +QA A Sbjct: 717 PNGLEDTPQFKLDVDQEKAQALGVSLSDINETISAALGGYYVNDFIDRGRVKKVYVQADA 776 Query: 771 SARMQLEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVAS 830 RM D+ LYVR+ +G MVP + A W +L+RY G P++ + G AAPG ++ Sbjct: 777 QFRMLPGDINNLYVRSANGEMVPFSTFSSARWIYGSPRLERYNGMPSMELLGEAAPGRST 836 Query: 831 GEAMAEMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 GEAM+ ME LA QLP G WTG S QERLSG Q Sbjct: 837 GEAMSLMENLASQLPNGIGYDWTGMSYQERLSGNQ 871 >PA2018 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1045 Score = 852 bits (2202), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/867 (49%), Positives = 600/867 (69%), Gaps = 3/867 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M RFFIDRP+FAWV++L IVL GV+A+ LP+A+YP +APP V+++A+YPGA+ + + + Sbjct: 1 MARFFIDRPVFAWVISLLIVLAGVLAIRFLPVAQYPDIAPPVVNVSASYPGASAKVVEEA 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V ++IERE++G LLY ++++ T G A +++TF+ G + +LA V+VQN+LK +E+RLP+ Sbjct: 61 VTAIIEREMNGAPGLLYTKATSST-GQASLTLTFRQGVNADLAAVEVQNRLKIVESRLPE 119 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 +VR++G+ VE AA S L+V+LTS GRYD + L + + N+++ LRR+EGVG+V+ +GA Sbjct: 120 SVRRDGIYVEKAADSIQLIVTLTSSSGRYDAMELGEIASSNVLQALRRVEGVGKVETWGA 179 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 E AMRIW DP KL + L+ +D+ A+ + NA++ G +G+ I+ + V L Sbjct: 180 EYAMRIWPDPAKLTSMNLSASDLVNAVRRHNARLTVGDIGNLGVPDSAPISATVKVDDTL 239 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 +P QF I L+ +ADG + L DVARVE G Y F +R N A AV+++PG+NAV Sbjct: 240 VTPEQFGEIPLRIRADGGAIRLRDVARVEFGQSEYGFVSRVNQMTATGLAVKMAPGSNAV 299 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 TA I+A ++EL P+G+++++PY+T+ FV+ISI+KVV TL+EAM+LVF VMYLF+Q Sbjct: 300 ATAKRIRATLDELSRYFPEGVSYNIPYDTSAFVEISIRKVVSTLLEAMLLVFAVMYLFMQ 359 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N R T+IP +V P+ALLGT VM G+S+NVLTMFGMVLAIGI+VDDAI+VVENVER+M Sbjct: 360 NFRATLIPTLVVPVALLGTFTVMLGLGFSINVLTMFGMVLAIGILVDDAIIVVENVERLM 419 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 A EGL P +AT+KAM +I+GAI+GIT+VL +VF+PMA G+VG IYRQF+V +AVSI F Sbjct: 420 AEEGLSPHDATVKAMRQISGAIVGITVVLVSVFVPMAFFSGAVGNIYRQFAVTLAVSIGF 479 Query: 481 SAFLALSLTPALCATLLRPVPAGHHDKRGFFGAFNRAFNRLTARYESALGRLIARGLRMM 540 SAFLALSLTPALCATLLRP+ A HH+KRGFFG FNRAF RLT RY +A+ ++AR +R M Sbjct: 480 SAFLALSLTPALCATLLRPIDADHHEKRGFFGWFNRAFLRLTGRYRNAVAGILARPIRWM 539 Query: 541 LVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGRE 600 LVY + G++ + LP AFLPEEDQG FM P T V ERYL E Sbjct: 540 LVYTLVIGVVALLFVRLPQAFLPEEDQGDFMIMVMQPEGTPMAETMANVGDVERYLAEHE 599 Query: 601 DIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAAME-SGV-DGMVM 658 + +V GF G G ++AM F LKDW ER+ ++ A+ + +G+ + V Sbjct: 600 PVAYAYAVGGFSLYGDGTSSAMIFATLKDWSERREASQHVGAIVERINQRFAGLPNRTVY 659 Query: 659 SLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKLSGVYSDGLPAGA 718 ++ P + +LG++SGF RLQDR GY AL A QLLA AA+ +L+ V G Sbjct: 660 AMNSPPLPDLGSTSGFDFRLQDRGGVGYEALVKARDQLLARAAEDPRLANVMFAGQGEAP 719 Query: 719 SVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARMQLED 778 ++L+IDR KA LGVS I+ TL+ GS Y+ DF + ++++V++QA + R+ ++D Sbjct: 720 QIRLDIDRRKAETLGVSMDEINTTLAVMFGSDYIGDFMHGSQVRKVVVQADGAKRLGIDD 779 Query: 779 VMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAMAEME 838 + +L+VRN+ G MVPLA KA+W P QL RY G+P+ + G AAPG +SGEAM ME Sbjct: 780 IGRLHVRNEQGEMVPLATFAKAAWTLGPPQLTRYNGYPSFNLEGQAAPGYSSGEAMQAME 839 Query: 839 RLAQQLPPGFAVAWTGQSLQERLSGGQ 865 +L Q LP G A W+GQS +ERLSG Q Sbjct: 840 QLMQGLPEGIAHEWSGQSFEERLSGAQ 866 >NMB1715 [V] COG0841 Cation/multidrug efflux pump Nme Neisseria meningitidis MC58 Length = 1067 Score = 852 bits (2201), Expect = 0.0, Method: Compositional matrix adjust. Identities = 443/871 (50%), Positives = 603/871 (69%), Gaps = 8/871 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPTVSINATYPGATPQTMNDG 60 M +FFIDRPIFAWV+++FI+ G+ + LP+++YPSVA PT+++ ATYPGA+ Q M D Sbjct: 1 MAKFFIDRPIFAWVISIFIIAAGIFGIKSLPVSQYPSVAAPTITLRATYPGASAQVMEDS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGTAQISVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V+S+IER ++GV+ L Y +SAD+SG+ +S+TF P TD LAQV+VQNKL + + LP Sbjct: 61 VLSVIERNMNGVEGLDYMSTSADSSGSGSVSLTFTPDTDENLAQVEVQNKLSEVLSTLPA 120 Query: 121 TVRQNGVTVESAASSFLLMVSLTSVDGRYDEVRLNDYLARNIVEELRRMEGVGRVQLFGA 180 TV+Q GVTV A S+FL++V L+S D + E +NDY RNIV EL+R+EGVG+V+LFGA Sbjct: 121 TVQQYGVTVSKARSNFLMIVMLSS-DVQSTE-EMNDYAQRNIVPELQRIEGVGQVRLFGA 178 Query: 181 EQAMRIWIDPFKLNAYGLTVTDISTAISQQNAQIAPGRLGDAPAVRGQQIAMPLTVQGQL 240 ++AMRIW+DP KL Y L+ D+ +A+S QN QI+ G +G PAVRGQ + +T QGQL Sbjct: 179 QRAMRIWVDPKKLQNYNLSFADVGSALSAQNVQISAGSIGSLPAVRGQTVTATVTAQGQL 238 Query: 241 QSPAQFAAIVLKAKADGSRVLLGDVARVELGAQSYAFANRENGKPAGVAAVQLSPGANAV 300 + +F ++L+A DGS V L DVARV LG + Y+ + R NG AV LS NA+ Sbjct: 239 GTAEEFGNVILRANTDGSNVYLKDVARVGLGMEDYSSSTRLNGVNTTGMAVMLSNSGNAM 298 Query: 301 RTAAAIQARMEELRPSLPQGMAFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 TA A++ RM L PQGM++ PY+T+ FV+ISI+KV+ TLIEAMVLVF+VMYLFLQ Sbjct: 299 ATAKAVKERMATLEKYFPQGMSWKTPYDTSKFVEISIEKVIHTLIEAMVLVFVVMYLFLQ 358 Query: 361 NVRYTVIPAIVAPIALLGTLAVMQLAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+RYT+IP IV PI+LLG A + G S+NVLTMF MVL IGI+VDDAIVVVENVERIM Sbjct: 359 NIRYTLIPTIVVPISLLGGFAFISYMGMSINVLTMFAMVLVIGIVVDDAIVVVENVERIM 418 Query: 421 AHEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSVAMAVSILF 480 A EGL P+EAT KAMG+I+GA+IGIT VL +VF+P+A+ G+ G IY+QF++ MA SI F Sbjct: 419 AGEGLPPKEATKKAMGQISGAVIGITAVLISVFVPLAMFSGATGNIYKQFALTMASSIAF 478 Query: 481 SAFLALSLTPALCATLLRPVPAGHH-DKRGFFGAFNRAFNRLTARYESALGRLIARGLRM 539 SAFLAL+LTPALCAT+L+ +P GHH +K+GFFG FN+ FN T YE + +++ + RM Sbjct: 479 SAFLALTLTPALCATMLKTIPKGHHEEKKGFFGWFNKKFNSWTHGYEGRVAKVLRKTFRM 538 Query: 540 MLVYAALSGLLVVGMQALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKGR 599 M+VY L+ + V LP++FLP EDQG+ M S QLPA AT ERT + Q + K Sbjct: 539 MVVYIGLAVVGVFLFMRLPTSFLPTEDQGFVMVSVQLPAGATQERTNATLAQVTQLAKSI 598 Query: 600 EDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTSAAEAMAAQAA---MESGVDGM 656 +I ++V GF FSGSG N AM F LKDW ER S A A+A + M + DG Sbjct: 599 PEIENIITVSGFSFSGSGQNMAMGFAILKDWNERTAPGSDAVAIAGKLTGMMMGTLKDGF 658 Query: 657 VMSLLPPAIEELGNSSGFAMRLQDRANQGYAALKAAEAQLLALAAKSGKL--SGVYSDGL 714 ++++PP I ELGN SG ++ LQDR N G+ AL A +L+ SG S V + GL Sbjct: 659 GIAVVPPPILELGNGSGLSINLQDRNNTGHTALLAKRNELIQKMRASGLFDPSTVRAGGL 718 Query: 715 PAGASVQLEIDRHKAAALGVSFSSISDTLSAAMGSFYVNDFPNAGRMQQVILQAQASARM 774 ++++I+R AAA G+SF+ I L++A+ S YV+DFPN GR+Q+V++QA ARM Sbjct: 719 EDSPQLKIDINRAAAAAQGISFADIRTALASALSSSYVSDFPNQGRLQRVMVQADEDARM 778 Query: 775 QLEDVMKLYVRNQSGGMVPLAELVKASWREAPTQLQRYQGFPAVRISGSAAPGVASGEAM 834 Q D++ L V N+SG VPL+ + SW Q R+ G+P++++S S A GV++G+AM Sbjct: 779 QPADILNLTVPNKSGVAVPLSTIATVSWENGTEQSVRFNGYPSMKLSASPATGVSTGQAM 838 Query: 835 AEMERLAQQLPPGFAVAWTGQSLQERLSGGQ 865 A ++++ +L G+++ W GQS +E G Q Sbjct: 839 AAVQKMVDELGGGYSLEWGGQSREEAKGGSQ 869