BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0173.p (169 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value TM0325 [IQR] COG1028 Dehydrogenases with different specificities... 112 4e-25 BS_ywfD [IQR] COG1028 Dehydrogenases with different specificitie... 109 4e-24 lin1921 [IQR] COG1028 Dehydrogenases with different specificitie... 102 3e-22 BS_fabG [IQR] COG1028 Dehydrogenases with different specificitie... 101 9e-22 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 100 1e-21 SMc02037 [IQR] COG1028 Dehydrogenases with different specificiti... 98 7e-21 NMB1921 [IQR] COG1028 Dehydrogenases with different specificitie... 97 1e-20 YPO1724 [IQR] COG1028 Dehydrogenases with different specificitie... 97 2e-20 NMA0533 [IQR] COG1028 Dehydrogenases with different specificitie... 96 3e-20 FN0494 [IQR] COG1028 Dehydrogenases with different specificities... 96 3e-20 >TM0325 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 251 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 66/166 (39%), Positives = 93/166 (56%), Gaps = 14/166 (8%) Query: 7 NIIEETEEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLV 66 NI E +EE +D TM VN KG +L SKYA+ Q KQ G +VN++ GL+ Sbjct: 95 NIEETSEEDFDKTMAVNVKGPFLLSKYAVEQMKKQGG----------GVIVNVSSEAGLI 144 Query: 67 GLALEPAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLAT----AMVRSFLEKEDTN 122 G+ Y SK A++ LTR LA+D+ I VNAVCPG + A V++ E+ Sbjct: 145 GIPRRCVYSVSKAALLGLTRSLAVDYVDYGIRVNAVCPGTTQSEGLMARVKASPNPEELL 204 Query: 123 KLLHDLTPWPRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAFTA 168 K + P R+G E++A A+ F A D+A +MTGS++ +DG TA Sbjct: 205 KKMTSRIPMKRLGKEEEIAFAILFAACDEAGFMTGSIINIDGGSTA 250 >BS_ywfD [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 255 Score = 109 bits (272), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 63/168 (37%), Positives = 95/168 (56%), Gaps = 17/168 (10%) Query: 9 IEETE-EQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVG 67 I E E ++ + VN G++L SK+A+ + A +G ++N +GGLV Sbjct: 98 IHEMELSDWNKVLQVNLTGMFLMSKHALKHML----------AAGKGNIINTCSVGGLVA 147 Query: 68 LALEPAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAM-VRSFLEK-----EDT 121 PAY ASKG V+ LT+ +A+D+A +I VN VCPG + T + +SFLE E+ Sbjct: 148 WPDIPAYNASKGGVLQLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEI 207 Query: 122 NKLLHDLTPWPRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAFTAR 169 K + P R+G E++A + FLASD + +MTGS +T DG +TA+ Sbjct: 208 KKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ 255 >lin1921 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Lin Listeria innocua Length = 247 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 58/154 (37%), Positives = 86/154 (55%), Gaps = 12/154 (7%) Query: 13 EEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVGLALEP 72 E+++D +N+N KG +L +K MKQ G+++N+A + GL+G A + Sbjct: 104 EDEWDDVININLKGTFLCTKAVSRTMMKQRA----------GKIINMASVVGLIGNAGQA 153 Query: 73 AYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDLTPWP 132 Y ASK V+ LT+ A + A INVNAV PGF+ T M +K T + + P Sbjct: 154 NYVASKAGVIGLTKTTARELAPRGINVNAVAPGFITTEMTDKLDDK--TKEAMLAQIPLG 211 Query: 133 RVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 G+ ED+A AV FLASD ++++TG L+VDG Sbjct: 212 AYGTTEDIANAVLFLASDASKYITGQTLSVDGGM 245 >BS_fabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 246 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 56/159 (35%), Positives = 88/159 (55%), Gaps = 12/159 (7%) Query: 8 IIEETEEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVG 67 I+ E+++D +N+N KG++ +K Q MKQ GR++N++ I G+ G Sbjct: 98 IMRMKEDEWDDVININLKGVFNCTKAVTRQMMKQRS----------GRIINVSSIVGVSG 147 Query: 68 LALEPAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHD 127 + Y A+K V+ LT+ A + A+ I VNA+ PGF++T M L K+ +++L Sbjct: 148 NPGQANYVAAKAGVIGLTKSSAKELASRNITVNAIAPGFISTDMTDK-LAKDVQDEMLKQ 206 Query: 128 LTPWPRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 + P R G DV+ VTFLAS+ A +MTG L +DG Sbjct: 207 I-PLARFGEPSDVSSVVTFLASEGARYMTGQTLHIDGGM 244 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 57/154 (37%), Positives = 82/154 (53%), Gaps = 12/154 (7%) Query: 13 EEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVGLALEP 72 EE +D ++ N KG++ SK MKQ GR++N++ + G +G A + Sbjct: 103 EEDWDAVIDTNLKGVFHCSKAVTRPMMKQR----------FGRIINVSSVVGAIGNAGQA 152 Query: 73 AYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDLTPWP 132 Y A+K V+ LT+ LA + A I VNAV PGF+ T M ED + P Sbjct: 153 NYVAAKAGVIGLTKTLARELANRNITVNAVAPGFIETDMTGEL--PEDVKAQMLGQIPLA 210 Query: 133 RVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 R+G E+VA+AV FLASDDA ++TG + V+G Sbjct: 211 RLGQPEEVAKAVRFLASDDASYLTGQTIHVNGGM 244 >SMc02037 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 256 Score = 98.2 bits (243), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 61/156 (39%), Positives = 87/156 (55%), Gaps = 12/156 (7%) Query: 14 EQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVG--LALE 71 E +D +N N G++ + AI + A RG +VNI I G + + Sbjct: 109 ETWDEVINTNLTGLFWCCRAAIE----------TMSAAGRGSIVNIGSISGYISNLPQNQ 158 Query: 72 PAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDLTPW 131 AY ASK V LT+ LA +FA I +NAV PG++ TAM + L+ + +K+ +TP Sbjct: 159 VAYNASKAGVHMLTKSLAGEFAKSNIRINAVAPGYIETAMTQGGLDDPEWSKIWLGMTPL 218 Query: 132 PRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAFT 167 R G A +VA AV FLASD A ++TGS+LT+DG +T Sbjct: 219 GRAGKASEVAAAVLFLASDAASYITGSVLTIDGGYT 254 >NMB1921 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Nme Neisseria meningitidis MC58 Length = 248 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 54/154 (35%), Positives = 83/154 (53%), Gaps = 12/154 (7%) Query: 13 EEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVGLALEP 72 EE++D M VN K ++ SK + MKQ GR++NI + G++G A + Sbjct: 104 EEEWDDIMQVNLKSVFRASKAVLRGMMKQRS----------GRIINITSVVGVMGNAGQT 153 Query: 73 AYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDLTPWP 132 Y A+K ++ ++ +A + + I VN V PGF+ T M R+ E+T + T Sbjct: 154 NYAAAKAGLIGFSKSMAREVGSRGITVNCVAPGFIDTDMTRAL--PEETRQTFTAQTALG 211 Query: 133 RVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 R G A+D+A AV FLASD A+++TG L V+G Sbjct: 212 RFGDAQDIADAVLFLASDQAKYITGQTLHVNGGM 245 >YPO1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 253 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 58/161 (36%), Positives = 91/161 (56%), Gaps = 9/161 (5%) Query: 9 IEETEEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVGL 68 I +E+ +D MNVN K ++ S+ QF+KQ G G+++N+A + G Sbjct: 102 INFSEKDWDDVMNVNIKSVFFMSQAVAKQFIKQ-----GNG----GKIINVASMLSYQGG 152 Query: 69 ALEPAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDL 128 P+Y ASK AV+ +TR LA ++A INVNAV PG++AT + + E+ +K + D Sbjct: 153 IRVPSYTASKSAVMGVTRLLANEWAKHGINVNAVAPGYMATNNTQQLRKDEERSKEILDR 212 Query: 129 TPWPRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAFTAR 169 P R G +D+ V FLAS +++++G + VDG + AR Sbjct: 213 IPAGRWGLPDDLKGPVVFLASKASDYISGYTIAVDGGWLAR 253 >NMA0533 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) NmA Neisseria meningitidis Z2491 Length = 248 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 54/154 (35%), Positives = 82/154 (53%), Gaps = 12/154 (7%) Query: 13 EEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVGLALEP 72 EE++D M VN K ++ SK + MKQ GR++NI + G++G A + Sbjct: 104 EEEWDDIMQVNLKSVFRASKAVLRGMMKQRS----------GRIINITSVVGVMGNAGQT 153 Query: 73 AYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHDLTPWP 132 Y A+K ++ + +A + + I VN V PGF+ T M R+ E+T + T Sbjct: 154 NYAAAKAGLIGFAKSMAREVGSRGITVNCVAPGFIDTDMTRAL--PEETRQAFTAQTALG 211 Query: 133 RVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 R G A+D+A AV FLASD A+++TG L V+G Sbjct: 212 RFGDAQDIADAVLFLASDQAKYITGQTLHVNGGM 245 >FN0494 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Fnu Fusobacterium nucleatum Length = 243 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 53/159 (33%), Positives = 86/159 (54%), Gaps = 12/159 (7%) Query: 8 IIEETEEQYDFTMNVNAKGIWLGSKYAITQFMKQEPITTSTGAKLRGRVVNIAYIGGLVG 67 ++ TE+Q+D +NVN KG+ F + ++ S +G ++ ++ + GL G Sbjct: 95 LMRMTEDQWDAVINVNLKGV----------FNMTQAVSRSMLKARKGSIITLSSVVGLHG 144 Query: 68 LALEPAYCASKGAVVNLTRELALDFAAERINVNAVCPGFLATAMVRSFLEKEDTNKLLHD 127 A + Y A+KG VV +++ A +F + N V PGF+ T M EDT K + D Sbjct: 145 NAGQTNYAATKGGVVAMSKTWAKEFGGRNVRANCVAPGFIQTPMTDVL--SEDTIKGMLD 202 Query: 128 LTPWPRVGSAEDVARAVTFLASDDAEWMTGSMLTVDGAF 166 TP R+G ED+A V FLASD++ ++TG +++V G Sbjct: 203 ATPLGRLGQVEDIANTVLFLASDESSFITGEVISVSGGL 241