BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0154.p (438 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Z5523 [GEPR] COG0477 Permeases of the major facilitator superfam... 287 4e-77 ECs4893 [GEPR] COG0477 Permeases of the major facilitator superf... 287 4e-77 PA4343 [GEPR] COG0477 Permeases of the major facilitator superfa... 282 1e-75 PA0703 [GEPR] COG0477 Permeases of the major facilitator superfa... 278 1e-74 RSc3060 [GEPR] COG0477 Permeases of the major facilitator superf... 278 2e-74 RSc3059 [GEPR] COG0477 Permeases of the major facilitator superf... 273 4e-73 RSp0536 [GEPR] COG0477 Permeases of the major facilitator superf... 273 8e-73 STM0689 [GEPR] COG0477 Permeases of the major facilitator superf... 257 3e-68 PA5476 [GEPR] COG0477 Permeases of the major facilitator superfa... 249 7e-66 proP [GEPR] COG0477 Permeases of the major facilitator superfami... 228 3e-59 >Z5523 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 438 Score = 287 bits (734), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 171/427 (40%), Positives = 249/427 (58%), Gaps = 12/427 (2%) Query: 19 VRKSEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFP-ATTPLASLLMTMATFGAG 77 V+K + RVI A GNALE FDF +++FF V I FFP + +LL+ ATFG Sbjct: 11 VKKKPSGRRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADKNVALLLAFATFGVS 70 Query: 78 FVMRPLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRL 137 F MRPLGG+++GA+ADRFGRKPAM+ +LM+ GT +IG+ P+Y++ G +V RL Sbjct: 71 FFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYETAGYWGTATLVLARL 130 Query: 138 LQGFSMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFL----- 192 +QG + GGEVGAS +LL E+A N RGF SW +A+QG A G + LS +L Sbjct: 131 IQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGVVALGLSAWLPFATG 190 Query: 193 SQQELDSWGWRLPFLFGLMLGPLGYAIR-SMLHETP-PIESRKGHAVRLVFSRFYH---P 247 S+ + WGWR+PF G++L P+G +R S+ ++ P P ++K A FS Sbjct: 191 SETVMAEWGWRVPFFIGVLLAPVGCWLRLSLENDVPEPAHNKKAAASESAFSLLMQHKAT 250 Query: 248 LITGVLLMTGGTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSD 307 + G+LL G T + +I +FY T+ L M + S LAG I VG+ G+L D Sbjct: 251 IANGILLAIGSTVATYISLFYYGTWAAKYLGMNQNYSHAAMLLAGVITFVGALLVGMLCD 310 Query: 308 HLARRKPFVIFSRLLGASLIYPAFWLLNHTAQPAFALVAIGTLAGCLTLGSGASFLLLVE 367 + R+K ++ SR++ +P+FWLL + P L + + TLG LL+ E Sbjct: 311 SVGRKK-LILISRVMVLICSWPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISE 369 Query: 368 SFPQAVRATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVSLIALIP 427 P+ +RA GF+LVYSIGV+IFGGFA + T I + +PA Y+ +++S++AL+ Sbjct: 370 LLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLDSLTAPAWYLGGGTLLSMLALLY 429 Query: 428 MKEHSTE 434 +KE + E Sbjct: 430 VKEPAKE 436 >ECs4893 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 438 Score = 287 bits (734), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 171/427 (40%), Positives = 249/427 (58%), Gaps = 12/427 (2%) Query: 19 VRKSEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFP-ATTPLASLLMTMATFGAG 77 V+K + RVI A GNALE FDF +++FF V I FFP + +LL+ ATFG Sbjct: 11 VKKKPSGRRVIFASAFGNALEFFDFGVYNFFVVYISTLFFPPSADKNVALLLAFATFGVS 70 Query: 78 FVMRPLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRL 137 F MRPLGG+++GA+ADRFGRKPAM+ +LM+ GT +IG+ P+Y++ G +V RL Sbjct: 71 FFMRPLGGIIVGAWADRFGRKPAMVFTIALMSLGTLMIGIAPTYETAGYWGTATLVLARL 130 Query: 138 LQGFSMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFL----- 192 +QG + GGEVGAS +LL E+A N RGF SW +A+QG A G + LS +L Sbjct: 131 IQGVAAGGEVGASMSLLVESAPANRRGFYSSWSLATQGLATTFGGVVALGLSAWLPFATG 190 Query: 193 SQQELDSWGWRLPFLFGLMLGPLGYAIR-SMLHETP-PIESRKGHAVRLVFSRFYH---P 247 S+ + WGWR+PF G++L P+G +R S+ ++ P P ++K A FS Sbjct: 191 SETVMAEWGWRVPFFIGVLLAPVGCWLRLSLENDVPEPAHNKKAAASESAFSLLMQHKAT 250 Query: 248 LITGVLLMTGGTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSD 307 + G+LL G T + +I +FY T+ L M + S LAG I VG+ G+L D Sbjct: 251 IANGILLAIGSTVATYISLFYYGTWAAKYLGMNQNYSHAAMLLAGVITFVGALLVGMLCD 310 Query: 308 HLARRKPFVIFSRLLGASLIYPAFWLLNHTAQPAFALVAIGTLAGCLTLGSGASFLLLVE 367 + R+K ++ SR++ +P+FWLL + P L + + TLG LL+ E Sbjct: 311 SVGRKK-LILISRVMVLICSWPSFWLLVNYPSPGMLLTVVFVMVSFTTLGGVPVMLLISE 369 Query: 368 SFPQAVRATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVSLIALIP 427 P+ +RA GF+LVYSIGV+IFGGFA + T I + +PA Y+ +++S++AL+ Sbjct: 370 LLPKRIRALGFALVYSIGVAIFGGFAQYFATQSIVLLDSLTAPAWYLGGGTLLSMLALLY 429 Query: 428 MKEHSTE 434 +KE + E Sbjct: 430 VKEPAKE 436 >PA4343 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 439 Score = 282 bits (721), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 165/418 (39%), Positives = 246/418 (58%), Gaps = 12/418 (2%) Query: 24 AKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVMRPL 83 ++ R +AA +GNALE +DF ++ F + +I + FFP+ SLLM +ATFG GF MRP+ Sbjct: 9 SRTRQVAAAVIGNALEWYDFIVYGFLSSLIARLFFPSGDEYTSLLMALATFGVGFFMRPV 68 Query: 84 GGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQGFSM 143 GG+++G YADR GRK AM L LM +I P+Y +IGV APLLIV R+LQGF+ Sbjct: 69 GGVLLGLYADRRGRKAAMQLIILLMTLSIAMIAFAPTYAAIGVGAPLLIVIARMLQGFAT 128 Query: 144 GGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSWGWR 203 GGE ++TA L E+A + RG SWQ+ Q A GA G L++ L + L+SWGWR Sbjct: 129 GGEYASATAFLVESAPPHRRGLYGSWQLFGQCLAVFAGAGMGALVTHCLDAEALESWGWR 188 Query: 204 LPFLFGLMLGPLGYAIRSMLHETPPI-----ESRKGHAVRLVFSRFYHPLITGVLLMTGG 258 +PFLFGL++GP+G IR + ET E + + V + ++ + L G Sbjct: 189 VPFLFGLLIGPVGLWIRRYMGETEAFLEAIREPGERQGLLGVLREYRRSVLVSMGLTVVG 248 Query: 259 TASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPFVIF 318 T S ++V+ MPT+ L +P F+ A A++ + P AG LSD + RR P ++ Sbjct: 249 TVSFYVVLVNMPTFAHKQLGLPLDEVFMVQMAAVALMTLVIPLAGGLSDRVGRR-PVLLV 307 Query: 319 SRLLGASLIYPAF-WLLNHTAQPAFALVAIGTLAGCLTLGS--GASFLLLVESFPQAVRA 375 + L ++YP F W+ A P+ + + L C +G G + + E FP VR+ Sbjct: 308 ATLAFMLMVYPLFAWV---AAAPSLGRLLLMQLLLCTAIGGFFGPAPTAVAEQFPVRVRS 364 Query: 376 TGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVSLIALIPMKEHST 433 TG ++ Y++ V +FGGFAPF+VTWL EV G P++PA Y++ + + L+A + ++E +T Sbjct: 365 TGLAVAYNLAVMLFGGFAPFIVTWLTEVGGSPVAPAFYVLGAAFLGLLATLYLREGAT 422 >PA0703 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 438 Score = 278 bits (712), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 184/432 (42%), Positives = 265/432 (61%), Gaps = 16/432 (3%) Query: 2 KPSSAPAFSDADAADKVVRKSEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPAT 61 P+ PA AAD R+S + AV +GNA+E FDF +++ FAVMIG+ FFP+ Sbjct: 3 SPTRPPA-----AADPASRRS------VFAVVLGNAVEFFDFGVYATFAVMIGRTFFPSD 51 Query: 62 TPLASLLMTMATFGAGFVMRPLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSY 121 + SLL+++ FG GFV+RPLG +++GAYADR GRKPAM+L LMA GTG I V P Y Sbjct: 52 SAFVSLLLSVTAFGVGFVIRPLGAVLIGAYADRAGRKPAMLLTLFLMALGTGGIAVLPGY 111 Query: 122 DSIGVLAPLLIVTGRLLQGFSMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVG 181 DSIG APLL+V RLLQG + GGE G +T + EAA + RG WQ+ +QG AA+ Sbjct: 112 DSIGPAAPLLLVLTRLLQGLAWGGEAGPATTYILEAAPPHKRGTYACWQVVAQGIAAVAA 171 Query: 182 ALTGYLLSTFLSQQELDSWGWRLPFLFGLMLGPLGYAIRSMLHETPPIESRKGHAVRL-- 239 L GYLL+ +L +++L WGWR+PF GL++ P+G IR L ET R+ L Sbjct: 172 GLMGYLLTLWLDERQLQEWGWRIPFAAGLLVLPIGLYIRLNLAETFSGRGRQASTRNLLG 231 Query: 240 -VFSRFYHPLITGVLLMTGGTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVG 298 +F L+ G+L+++G T + + + YM T+ + LH+P ++ L +AGA L + Sbjct: 232 ELFGNHRRALLLGLLILSGSTITQYFLN-YMTTFALTELHLPAGIAMLSTLVAGAALALS 290 Query: 299 SPFAGLLSDHLARRKPFVIFSRLLGASLIYPAFWLLNHTAQPAFALVAIGTLAGCLTLGS 358 + G+L D RR +I RL ++++PA + +PA L + L+ + Sbjct: 291 ALLGGVLCDRYGRRA-VLILPRLALLAVLFPALQAMTRHPEPAVFLAVLALLSALHGMSG 349 Query: 359 GASFLLLVESFPQAVRATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCS 418 A +LLVESFP+A+R+TGFSLVY+ GV+ FGG A VVTWLI V+G+P+SP Y+++ + Sbjct: 350 AALIVLLVESFPRALRSTGFSLVYATGVAAFGGTAQIVVTWLIGVTGNPLSPLGYLLLAN 409 Query: 419 IVSLIALIPMKE 430 +V L+ +E Sbjct: 410 LVCLVGAWLARE 421 >RSc3060 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 278 bits (711), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 172/422 (40%), Positives = 237/422 (56%), Gaps = 13/422 (3%) Query: 22 SEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVMR 81 +E+K R I V GN LEMFDF ++ ++A I FFPA SL++++ TFGAGF+MR Sbjct: 7 NESKARAIFRVVSGNFLEMFDFMVYGYYATAIAATFFPAGNAFLSLMLSLMTFGAGFLMR 66 Query: 82 PLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQGF 141 PLG +V+GAY DR GR+ ++L LMA GT +I + P Y +IG+ APLL++ GRLLQGF Sbjct: 67 PLGAIVLGAYIDRHGRRAGLILTLVLMACGTMLIALVPGYGTIGLAAPLLVLIGRLLQGF 126 Query: 142 SMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSWG 201 S GGE G + L+E A +GF +SWQ SQ A + AL G LLS LS +E+ WG Sbjct: 127 SAGGEPGGVSVYLSEIATPGRKGFYVSWQSGSQQVAVMFAALLGVLLSFKLSPKEMGEWG 186 Query: 202 WRLPFLFGLMLGPLGYAIRSMLHETPPIESRK-----GHAVRLVFSRFYHPLITGVLLMT 256 WR+PFL G ++ P + IR L ET E RK G +R + G LL Sbjct: 187 WRVPFLIGCLIVPFLFFIRRSLRETEEFEQRKHRPTMGELLR-SMGENWRLAGAGTLLAV 245 Query: 257 GGTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPFV 316 T S +++ Y PT+ LHM S + GA L+ P G LSD + RR P + Sbjct: 246 MTTVSFYLITAYTPTFGRNVLHMSDFDSLIVTLCVGASNLIWLPVMGSLSDRIGRRTPLI 305 Query: 317 IFSRLLGASLIYPAF-WLLNHTAQPAFA-LVAIGTLAGCLTLG-SGASFLLLVESFPQAV 373 +FS L + YPA WL+ A+P+F L+A+ L G +GA + L E P + Sbjct: 306 VFSALTLLT-AYPAMTWLI---AEPSFGRLLAVELWLSFLYGGYNGAMIVTLTEIMPPQL 361 Query: 374 RATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVSLIALIPMKEHST 433 R TGFSL YS+ +IFGGF P + T LI +G+ P ++ +I L+A + + + Sbjct: 362 RTTGFSLAYSLATAIFGGFTPAIATGLIHATGNKAMPGLWLSFAAICGLVATLTVVKPQP 421 Query: 434 EP 435 P Sbjct: 422 RP 423 >RSc3059 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 431 Score = 273 bits (699), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 168/421 (39%), Positives = 236/421 (56%), Gaps = 15/421 (3%) Query: 22 SEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVMR 81 +E+K R I V GN LEM+DF ++ ++A I FFPA SL++++ TFG GF+MR Sbjct: 7 NESKARSIFRVVSGNFLEMYDFMVYGYYAKAIADTFFPADNEFLSLMLSLVTFGVGFLMR 66 Query: 82 PLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQGF 141 PLG L++GAY DR GR+ ++L LMA GT +I + P Y +IG+ APLL++ GRLLQGF Sbjct: 67 PLGALILGAYIDRHGRRAGLILTLGLMACGTLLIALVPGYATIGLAAPLLVLIGRLLQGF 126 Query: 142 SMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSWG 201 S G E+G + LAE + +GF +SWQ ASQ A + AL G LLS LS +E+ WG Sbjct: 127 SAGVELGGVSVYLAEISTPGRKGFFVSWQSASQQVAVMFAALLGVLLSFQLSPKEMGEWG 186 Query: 202 WRLPFLFGLMLGPLGYAIRSMLHETPPIESRKGH-AVRLVFSRF---YHPLITGVLLMTG 257 WR+PFL G ++ P + IR L ET + RK A+ +F + + G LL+ Sbjct: 187 WRVPFLVGCLIVPFLFLIRRSLQETEEFKQRKHRPALGEIFRSMGENWRLVGAGTLLVVM 246 Query: 258 GTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPFVI 317 T S +++ Y PT+ LH+ S + GA P G +SD + RR + Sbjct: 247 TTVSFYLITAYTPTFGKSVLHLSNLDSLIVTLCVGASNFFWLPVMGSVSDRIGRRPLLIT 306 Query: 318 FSRLLGASLIYPAF-WLLNHTAQPAFALVAIGTLAGCLTLGS--GASFLLLVESFPQAVR 374 F+ L + YPA WL+ A+P+F + L GS GA + L E P AVR Sbjct: 307 FTALTLLT-AYPAMQWLI---AEPSFGRLLAVELWLSFLYGSYNGAMVVTLTEIMPPAVR 362 Query: 375 ATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYM---IVCSIV-SLIALIPMKE 430 TGFSL YS+ +IFGGF P + TWLI +G+ P ++ +C +V +LI + P Sbjct: 363 TTGFSLAYSLATAIFGGFTPAIATWLIHATGNKAMPGLWLSFAAICGLVATLIVVKPAGR 422 Query: 431 H 431 H Sbjct: 423 H 423 >RSp0536 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 441 Score = 273 bits (697), Expect = 8e-73, Method: Compositional matrix adjust. Identities = 164/419 (39%), Positives = 243/419 (57%), Gaps = 22/419 (5%) Query: 29 IAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVMRPLGGLVM 88 +A +GNA E FDFT++ FFA +I FP+ P +LL+ +ATFG GFV RPLGG+V+ Sbjct: 22 VATAILGNAFEWFDFTLYGFFAPVIATVLFPSANPFTALLLAIATFGVGFVTRPLGGIVL 81 Query: 89 GAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQGFSMGGEVG 148 G YADR GR+PA+ L LMA GT +I + P+Y G+ AP++ V RLLQGFS GGE+G Sbjct: 82 GIYADRRGRRPALALSALLMALGTALIAIAPTYAQAGIAAPVIAVIARLLQGFSAGGEMG 141 Query: 149 ASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSWGWRLPFLF 208 +TA L E A R F SW AS G A + GA+ G L ++ L + L +WGWR+PF Sbjct: 142 GATAYLNEIAPPGKRAFYTSWIQASVGLAIVCGAMLGTLATSLLDAEALRAWGWRIPFAL 201 Query: 209 GLMLGPLGYAIRSMLHETPPI-----ESRKGHAVRLVFSRFYHPLITGVLLMTGGTASMF 263 G+++GP+GY IRS L ETP E+R + V R ++ G ++ T + Sbjct: 202 GVLIGPIGYVIRSRLDETPAFARAATEARADSPLLEVVRRHRRAVLIGASIVILWTVCTY 261 Query: 264 IVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPFVIFSRLLG 323 +++FYM TY + L +P+S F G+ +G +++ +P G L+D L + R+L Sbjct: 262 VLLFYMQTYAIHVLKLPSSAGFAGSMASGVTMMLTAPLFGWLADRLG-------YQRVLS 314 Query: 324 AS------LIYPAFWLLNHTAQPAFALVAIGTLAGCLTLG-SGASFLLLVESFPQAVRAT 376 + L YP + LNH A A L+ + + G L+ +G + + FP V +T Sbjct: 315 GAALAILVLAYPLYAYLNH-APAAGTLIGVQIVFGLLSAAYTGPIPVAFADLFPTKVLST 373 Query: 377 GFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPM-SPAHYMIVCSIVSLIALIPMKEHSTE 434 G S Y++ V + GGFAPF +TWL + DPM +P Y++V ++VSLI + ++ + + Sbjct: 374 GLSTAYNLTVMLIGGFAPFYLTWLSH-AFDPMLAPVLYVMVAALVSLIGTLWLRAAAAD 431 >STM0689 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 434 Score = 257 bits (657), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 154/406 (37%), Positives = 222/406 (54%), Gaps = 11/406 (2%) Query: 26 FRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVMRPLGG 85 F I VT GN LE FDF +F F+A I + FFPA + ASL++T A FG+GF+MRP+G Sbjct: 14 FGAILRVTSGNFLEQFDFFLFGFYATYIARTFFPAESEFASLMLTFAVFGSGFLMRPVGA 73 Query: 86 LVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQGFSMGG 145 +V+GAY DR GR+ +M+ ++M GT +I + P Y +IG+ AP L++ GRLLQGFS G Sbjct: 74 IVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGV 133 Query: 146 EVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSWGWRLP 205 E+G + L+E A ++GF SWQ ASQ A +V AL GY L+ L + WGWR+P Sbjct: 134 ELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAISEWGWRIP 193 Query: 206 FLFGLMLGPLGYAIRSMLHETPPIESRKGH-AVRLVF---SRFYHPLITGVLLMTGGTAS 261 F G M+ PL + +R L ET RK R +F ++ + + G LL+ T + Sbjct: 194 FFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTT 253 Query: 262 MFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPFVIFSRL 321 + + Y PTY L++ S + L G + P G +SD + RR + + L Sbjct: 254 FYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGIT-L 312 Query: 322 LGASLIYPAF-WLLNHTAQPAFALVAIGTLAGCLTLG--SGASFLLLVESFPQAVRATGF 378 L +P WL TA P F + + L G +GA L E P VR GF Sbjct: 313 LALITTWPVMQWL---TAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGF 369 Query: 379 SLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVSLIA 424 SL +S+ +IFGG P + T L++++GD SP +++ ++ L A Sbjct: 370 SLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAA 415 >PA5476 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 429 Score = 249 bits (637), Expect = 7e-66, Method: Compositional matrix adjust. Identities = 159/402 (39%), Positives = 221/402 (54%), Gaps = 25/402 (6%) Query: 21 KSEAKFRVIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVM 80 K A FRV++ GN LEM+DF ++ F+A I K FFP P ASL++++ATFGAGF+M Sbjct: 7 KGVAIFRVVS----GNFLEMYDFMVYGFYATAIAKTFFPGDNPFASLMLSLATFGAGFLM 62 Query: 81 RPLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQG 140 RPLG + +GAY DR GR+ +++ LMA GT +I P Y ++GV APLL++ GRLLQG Sbjct: 63 RPLGAVFLGAYIDRHGRRQGLIITLGLMAMGTLLIAFVPGYATLGVAAPLLVLFGRLLQG 122 Query: 141 FSMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSW 200 FS G E+G + L+E A +GF +SWQ ASQ A + L G LL+ +LS Q++ W Sbjct: 123 FSAGVELGGVSVYLSEIATPGRKGFFVSWQSASQQVAVVFAGLLGVLLNQWLSPQDMGEW 182 Query: 201 GWRLPFLFGLMLGPLGYAIRSMLHETPPIESRK-----GHAVRLVFSRFYHPLITGVLLM 255 GWR+PF G ++ P + IR L ETP E+R +R + F ++ G ++ Sbjct: 183 GWRVPFFIGCLIVPALFVIRRSLEETPEFEARTHRPSLSQVLRSIGQNF-GVVLAGTAMV 241 Query: 256 TGGTASMFIVVFYMPTYLVVGLHMPTSVSFLGACLAGAILLVGSPFAGLLSDHLARRKPF 315 T S +++ Y PT+ L + S L G + P G SD + RKP Sbjct: 242 VMTTVSFYLITAYTPTFGKNELQLSDLDSLLVTMCIGLSNFIWLPVMGAFSDRIG-RKPL 300 Query: 316 VIFSRLLGASLIYPAF-WLLNHTAQPAFALVAIGTLAGCLTLG------SGASFLLLVES 368 ++ + L YPA WL+ +P+FA G L L L +GA + L E Sbjct: 301 LLGASALALLTAYPALSWLVR---EPSFA----GLLGVELWLSFLYSSYNGAMVVALTEV 353 Query: 369 FPQAVRATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSP 410 P VR TGFSL YS+ + FGGF P V TWLI + +P Sbjct: 354 MPADVRTTGFSLAYSLATATFGGFTPAVCTWLIHTLDNRAAP 395 >proP [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 500 Score = 228 bits (580), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 148/435 (34%), Positives = 232/435 (53%), Gaps = 27/435 (6%) Query: 22 SEAKFR-VIAAVTVGNALEMFDFTIFSFFAVMIGKQFFPATTPLASLLMTMATFGAGFVM 80 + K R I A ++GNA+E FDF ++ F A +GK FFP P ++ +ATF F++ Sbjct: 19 DDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLI 78 Query: 81 RPLGGLVMGAYADRFGRKPAMMLCTSLMAAGTGIIGVTPSYDSIGVLAPLLIVTGRLLQG 140 RPLGGL G D++GR+ + + +M+ T IG+ PSYD+IG+ AP+L++ ++ QG Sbjct: 79 RPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYDTIGIWAPILLLICKMAQG 138 Query: 141 FSMGGEVGASTALLAEAALRNSRGFMISWQMASQGAAALVGALTGYLLSTFLSQQELDSW 200 FS+GGE ++ +AE + RGFM SW A ++GA L+ST + + W Sbjct: 139 FSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIVGEANFLDW 198 Query: 201 GWRLPFLFGLMLGPLGYAIRSMLHETPPIE---------SRKGH------AVRLVFSRFY 245 GWR+PF L LG +G +R L ETP + R+G + + + ++++ Sbjct: 199 GWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLQDGPKVSFKEIATKYW 258 Query: 246 HPLITGVLLMTGGTASMFIVVFYMPTYLVVGLHMPTS--VSFLGACLAGAILLVGSPFAG 303 L+T + L+ + ++++ YMP+YL LH V + A + G +L P G Sbjct: 259 RSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIG--MLFVQPVMG 316 Query: 304 LLSDHLARRKPFVIFSRLLGASLIYPAFWLLN-HTAQPAFA-LVAIGTLAGCLTLGSGAS 361 LLSD RR PFV+ + L PAF L+N + FA L+ + + C T G AS Sbjct: 317 LLSDRFGRR-PFVLLGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFT-GVMAS 374 Query: 362 FLLLVESFPQAVRATGFSLVYSIGVSIFGGFAPFVVTWLIEVSGDPMSPAHYMIVCSIVS 421 L FP +R + + ++I V + G P + WL+E S + M PA+Y++V ++V Sbjct: 375 --TLPAMFPTHIRYSALAAAFNISV-LVAGLTPTLAAWLVESSQNLMMPAYYLMVVAVVG 431 Query: 422 LIALIPMKEHSTEPL 436 LI + MKE + PL Sbjct: 432 LITGVTMKETANRPL 446