BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0114.p (493 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4899 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pse... 342 1e-93 BH2010 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bha Bac... 295 2e-79 Cgl2615 [C] COG1012 NAD-dependent aldehyde dehydrogenases Cgl Co... 283 8e-76 BH1005 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bha Bac... 278 2e-74 BS_yfmT [C] COG1012 NAD-dependent aldehyde dehydrogenases Bsu Ba... 277 4e-74 BS_aldY [C] COG1012 NAD-dependent aldehyde dehydrogenases Bsu Ba... 221 4e-57 VNG2513G [C] COG1012 NAD-dependent aldehyde dehydrogenases Hbs H... 212 2e-54 RSp0229 [C] COG1012 NAD-dependent aldehyde dehydrogenases Rso Ra... 177 4e-44 CC2397 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ccr Cau... 169 1e-41 PAE2480 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pya Py... 167 4e-41 >PA4899 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pseudomonas aeruginosa Length = 489 Score = 342 bits (876), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 169/278 (60%), Positives = 210/278 (75%) Query: 17 QYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSER 76 Q + G+WR G A L+ +P+ G LL EI +A DLDAAYA AA+ Q AWAA+ PS R Sbjct: 12 QPLAGEWRHGRAGRRLKVSNPFDGSLLLEIEQADRDDLDAAYAKAAEVQPAWAALGPSAR 71 Query: 77 AALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILP 136 AA+ +A + D+RH EIVDW+IRESGSTR+KAEIEW A ++ L + + PARVHGRI+ Sbjct: 72 AAVLYKAVEVFDRRHEEIVDWIIRESGSTRLKAEIEWGAARAITLESASFPARVHGRIVE 131 Query: 137 IDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLL 196 D+ G+ESRVYR +GVVGVISPWN+P+HL+ RSIAPALA+GNAVVVKPA DTPV GGLL Sbjct: 132 SDVPGKESRVYRSAIGVVGVISPWNFPLHLTQRSIAPALALGNAVVVKPASDTPVCGGLL 191 Query: 197 LAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTI 256 LA+I+EEAGLP GL +VV+G SEIGDAF HP P ++FTGST VGR+IG +A G + Sbjct: 192 LARIFEEAGLPAGLFSVVVGPGSEIGDAFVEHPVPGLVTFTGSTPVGRNIGRIASGGAHL 251 Query: 257 KRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 K V LELGGN+P VVL DADLE+AV+ A+ +G+ Sbjct: 252 KHVALELGGNSPFVVLGDADLEQAVNAAVFGKFLHQGQ 289 >BH2010 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bha Bacillus halodurans Length = 485 Score = 295 bits (754), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 140/281 (49%), Positives = 198/281 (70%), Gaps = 2/281 (0%) Query: 14 FTGQYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLP 73 +T Q++ G+W EGA+ + +++PYTG+ + EI+ ASL DLD AY AA AQ+ W LP Sbjct: 5 YTRQFLAGEWIEGASTQTITNYNPYTGEKIHEIKGASLDDLDQAYRAAKNAQKEWEQTLP 64 Query: 74 SERAALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGR 133 +++ + +AAA++ +R E+++ L+ E+GS+ IKA IEW A + A P R+ G+ Sbjct: 65 AQKQEVLEKAAALLAERKDEVIERLVNEAGSSIIKASIEWGATLQTIKVAATFPLRMEGK 124 Query: 134 ILPIDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTG 193 ILP +I G+E+R+YR GV+GVISP+N+P+ L+ RS+APALA GNAVV+K + D P+T Sbjct: 125 ILPSNIPGKENRIYRSAKGVIGVISPFNFPLVLAMRSVAPALATGNAVVLKCSSDAPITS 184 Query: 194 GLLLAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTG 253 GLL+A+++EEAGLP G+LNVV+G +EIGDAF HP PK ISFTGST VGRHI LA Sbjct: 185 GLLIAELFEEAGLPKGVLNVVVGKAAEIGDAFVTHPIPKLISFTGSTEVGRHIAQLA--A 242 Query: 254 PTIKRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 +K LELGGN +VLDDAD+E+A + A + +G+ Sbjct: 243 RELKETALELGGNNVMIVLDDADIEKAAEKAAVGKFLHQGQ 283 >Cgl2615 [C] COG1012 NAD-dependent aldehyde dehydrogenases Cgl Corynebacterium glutamicum Length = 484 Score = 283 bits (723), Expect = 8e-76, Method: Compositional matrix adjust. Identities = 142/258 (55%), Positives = 185/258 (71%) Query: 15 TGQYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPS 74 T I GQW EG + + + +PY ++ E ++AS+ D+DAAY AA +AQ WAA + Sbjct: 11 TKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKAQAEWAATPAA 70 Query: 75 ERAALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRI 134 ER+A+ RAA ++++ EIV+WLI+ESGSTR KA +E + + + P RVHGRI Sbjct: 71 ERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNITKESASFPGRVHGRI 130 Query: 135 LPIDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGG 194 P + G+E+RVYR GVVGVISPWN+P++LS RS+APALAVGNAVV+KPA DTPVTGG Sbjct: 131 SPSNTPGKENRVYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPASDTPVTGG 190 Query: 195 LLLAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGP 254 ++ A+I+EEAG+P G+++ V GA SEIGD F H PK ISFTGST VGR +G LA+ G Sbjct: 191 VIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGG 250 Query: 255 TIKRVGLELGGNAPCVVL 272 +K V LELGGNAP VVL Sbjct: 251 PMKTVALELGGNAPFVVL 268 >BH1005 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bha Bacillus halodurans Length = 485 Score = 278 bits (711), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 137/283 (48%), Positives = 187/283 (66%), Gaps = 2/283 (0%) Query: 12 QGFTGQYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAV 71 Q QYIDG+WR+G + +L+D +PY ++L E + A+ D+DAAY AA +AQ WA V Sbjct: 5 QDLNKQYIDGEWRDGKSPRVLRDRNPYNQEVLAEFQIATDSDVDAAYHAALKAQNEWATV 64 Query: 72 LPSERAALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVH 131 P + + RA +++ EIV +I E G TR+KA E VK+ + A+ P R+ Sbjct: 65 NPYRKREILERAVTYIEEHEEEIVAIIIDELGGTRLKAAFEIGLVKNMIKEASTFPLRME 124 Query: 132 GRILPIDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPV 191 G+ILP G+E+R+YR P GVVGVISP+N+P LS +S+APAL GN VV+KP ++TP+ Sbjct: 125 GKILPSTENGKENRLYRVPAGVVGVISPFNFPFFLSVKSVAPALGAGNGVVLKPHEETPI 184 Query: 192 TGGLLLAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAM 251 TGG L+AKI+EEAG+P GLLNVV+ + EIG+AF HP P+ ISFTGST VG HIG LA+ Sbjct: 185 TGGTLIAKIFEEAGVPKGLLNVVVTEIDEIGNAFVEHPIPRIISFTGSTNVGSHIGQLAV 244 Query: 252 TGPTIKRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 K+ LELGGN+ ++ DADL+ AV A +G+ Sbjct: 245 K--HFKKPLLELGGNSAFLIFADADLDYAVQAATFSRFTHQGQ 285 >BS_yfmT [C] COG1012 NAD-dependent aldehyde dehydrogenases Bsu Bacillus subtilis Length = 485 Score = 277 bits (709), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 131/278 (47%), Positives = 191/278 (68%), Gaps = 2/278 (0%) Query: 17 QYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSER 76 Q+I G+W+EG++ ++L++ +PYT + T R+A+ D+D AY AAA A++ W AV P E+ Sbjct: 10 QFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATADDVDEAYRAAALAKKKWDAVNPFEK 69 Query: 77 AALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILP 136 + +A +++ I+ ++ E G TR+KA E VK+ + A P R+ G+ILP Sbjct: 70 RTILEKAVTYIEENEEAIIYLIMEELGGTRLKAAFEIGLVKNIIKEAATFPIRMEGKILP 129 Query: 137 IDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLL 196 I G+E+R+YR P GVVGVISP+N+P LS +S+APAL GN VV+KP ++TP+ GG L Sbjct: 130 STIDGKENRLYRVPAGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEETPICGGTL 189 Query: 197 LAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTI 256 +AKI+E AG+P GLLNVV+ ++EIGD+F HP P+ ISFTGST+VG +IG LAM Sbjct: 190 IAKIFENAGIPAGLLNVVVTDIAEIGDSFVEHPVPRIISFTGSTKVGSYIGQLAMK--HF 247 Query: 257 KRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 K+ LELGGN+ +VL+DAD+E AV+ A+ +G+ Sbjct: 248 KKPLLELGGNSAFIVLEDADIEYAVNAAVFSRFTHQGQ 285 >BS_aldY [C] COG1012 NAD-dependent aldehyde dehydrogenases Bsu Bacillus subtilis Length = 485 Score = 221 bits (562), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 117/278 (42%), Positives = 171/278 (61%), Gaps = 3/278 (1%) Query: 18 YIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSERA 77 +I+G+W G + +PY ++T A+ L+ A+ A +AQ+ WA +R Sbjct: 10 FINGKWTGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQKEWAKSTTEDRK 69 Query: 78 ALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHG-RILP 136 A+ +A + + +I+ + RE+G T IK+ IE + + A + G + +P Sbjct: 70 AVLQKARGYLHENRDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGGVKEVP 129 Query: 137 IDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLL 196 DI G+ +++YR PLGV+ ISP+N+PM+LS RSIAPA+A+GN+VV KP T ++GG + Sbjct: 130 SDIEGKTNKIYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTAISGGTI 189 Query: 197 LAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTI 256 +AK +E AGLP G+LNV++ V EIGD +P P+ ISFTGST VGRHIG +A G Sbjct: 190 IAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIA--GRAF 247 Query: 257 KRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 KR+ LELGGN P VL DAD++RAVD AI +G+ Sbjct: 248 KRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQ 285 >VNG2513G [C] COG1012 NAD-dependent aldehyde dehydrogenases Hbs Halobacterium sp. NRC-1 Length = 489 Score = 212 bits (539), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 128/278 (46%), Positives = 170/278 (61%), Gaps = 2/278 (0%) Query: 17 QYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSER 76 QYIDG++ L+ DP T +L TEI + D+DAAY AAA AQ WA P ER Sbjct: 14 QYIDGEYVPPGDRGTLEVDDPSTRELFTEIPAGTTDDVDAAYEAAADAQTEWADTPPQER 73 Query: 77 AALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILP 136 A + A+ I+ E+VD L ESG+T K E+ A A + P R++G Sbjct: 74 ARIVAAASEILASHRDEVVDLLATESGTTYTKGAAEFEASVGITDEAASFPTRMNGDHKQ 133 Query: 137 IDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLL 196 + G+E+ V R P GVVG+ISPWN+P++LS R++APA+A GN+VV+KPA +TPVTGGLL Sbjct: 134 SVVEGKENIVVREPQGVVGIISPWNFPLNLSIRAVAPAVAAGNSVVLKPASNTPVTGGLL 193 Query: 197 LAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTI 256 +AK++E AGLP G+ NVV G SEIGD HP ISFTGST +GR + A A G + Sbjct: 194 IAKVFEAAGLPEGVFNVVTGKGSEIGDRIAGHPHADVISFTGSTAIGRQVAATA--GENL 251 Query: 257 KRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 +ELGGN +V +DADL+ AVD + + G+ Sbjct: 252 ALPAMELGGNNVHIVTEDADLDDAVDSGVFGSFLHSGQ 289 >RSp0229 [C] COG1012 NAD-dependent aldehyde dehydrogenases Rso Ralstonia solanacearum Length = 492 Score = 177 bits (450), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 120/249 (48%), Positives = 158/249 (63%), Gaps = 4/249 (1%) Query: 36 DPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSERAALFLRAAAIMDQRHAEIV 95 +P TG+ LT + A D+DAA AAA AQ AW A+ P ERA +F RAA + +Q E+ Sbjct: 37 EPATGRKLTRVGLADAQDVDAAVEAAAAAQPAWVAMPPRERANVFRRAAMLFEQHFDELA 96 Query: 96 DWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILPIDIAGRESRVYRRPLGVVG 155 + RE+G+ K E E + A MP G++L AGR S R P GVVG Sbjct: 97 LAIARETGAALFKGEHEVREAITLCHVAAGMPLEAQGQVLA-SPAGRLSYARRAPFGVVG 155 Query: 156 VISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLLLAKIYEEAGLPPGLLNVVI 215 VISP+N+P+ L+ RS+APALA GNAVV+KP TPV+GG ++A+++ EAGLP GLL+V+ Sbjct: 156 VISPFNFPLFLTLRSVAPALAAGNAVVIKPDLRTPVSGGYVIARVFAEAGLPAGLLHVLP 215 Query: 216 GAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTIKRVGLELGGNAPCVVLDDA 275 G +E G+A +HP I+FTGS VGR IG LA G +K+V LELGG ++LDDA Sbjct: 216 GG-AEAGEALVVHPRVPMIAFTGSPGVGRRIGELA--GRHLKKVSLELGGANALIILDDA 272 Query: 276 DLERAVDGA 284 DL+ AV A Sbjct: 273 DLDLAVSNA 281 >CC2397 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ccr Caulobacter vibrioides Length = 487 Score = 169 bits (429), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 109/242 (45%), Positives = 151/242 (62%), Gaps = 4/242 (1%) Query: 35 HDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSERAALFLRAAAIMDQRHAEI 94 +P T +LT++ A D+ A A+A AQ AWAA+ R A+ LRAA ++ + ++ Sbjct: 31 QEPATETVLTQVGRADRSDVARAAASAKAAQPAWAALTADARQAILLRAADLLVEHAPDL 90 Query: 95 VDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILPIDIAGRESRVYRRPLGVV 154 W++RESGS KA +E + A AM G +LP G+ S R PLGVV Sbjct: 91 APWIMRESGSVAAKAAVELEHAAGFVRQAGAMATEAAGLVLPSS-PGKTSIARRVPLGVV 149 Query: 155 GVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLLLAKIYEEAGLPPGLLNVV 214 VISP+N+P+ LS R++APALA GNAVV+KP TP++GG L+A+++E AGLP GLL+V+ Sbjct: 150 AVISPFNFPLVLSIRAVAPALATGNAVVLKPDPRTPISGGFLIARVFEAAGLPAGLLHVL 209 Query: 215 IGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTIKRVGLELGGNAPCVVLDD 274 G +E GDA P ++FTGST GR +G +A G +K+V LELGG P ++LDD Sbjct: 210 PGD-AEAGDALCRDPNIAMVAFTGSTGAGRKVGEVA--GAHLKKVALELGGKNPLIILDD 266 Query: 275 AD 276 AD Sbjct: 267 AD 268 >PAE2480 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pya Pyrobaculum aerophilum Length = 478 Score = 167 bits (424), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 101/278 (36%), Positives = 151/278 (54%), Gaps = 5/278 (1%) Query: 17 QYIDGQWREGAAASLLQDHDPYTGQLLTEIREASLGDLDAAYAAAAQAQQAWAAVLPSER 76 YI+G++ E H P G ++ E + D AA AA A +AW+ + +R Sbjct: 6 NYINGEFIE--VEERRPKHSPIDGSVIAETPVSKREDAKAAIDAAYDALKAWSQLPAIKR 63 Query: 77 AALFLRAAAIMDQRHAEIVDWLIRESGSTRIKAEIEWAAVKSGMLAATAMPARVHGRILP 136 A + I+ R E+++ L+ E G KA E + + A + G+ L Sbjct: 64 AEYLYKLYEIIKSREEELINILMVEGGGIYKKAWGEVVFTERLVRNAAELARHYGGKTLQ 123 Query: 137 IDIAGRESRVYRRPLGVVGVISPWNWPMHLSNRSIAPALAVGNAVVVKPADDTPVTGGLL 196 D G S V++RP GVVGVI+PWN+P+ +S + IA ALA GN +V KPA +TPVT G Sbjct: 124 SDAEGVVSMVFKRPKGVVGVITPWNYPLSISMKKIAHALATGNTIVYKPASETPVT-GFK 182 Query: 197 LAKIYEEAGLPPGLLNVVIGAVSEIGDAFTLHPTPKFISFTGSTRVGRHIGALAMTGPTI 256 +A++ +AG P G+ N+V+G S +GD ++ ++FTG + GR I + A G + Sbjct: 183 IAEMIHQAGFPKGVFNLVVGPGSTVGDEIVVNKKVSHVTFTGESATGREIASKA--GGAL 240 Query: 257 KRVGLELGGNAPCVVLDDADLERAVDGAILVASCTRGR 294 K V LELGG+ P ++LDDADL AV A+ A +G+ Sbjct: 241 KTVTLELGGSDPLIILDDADLNLAVRIAVFGAFFHQGQ 278