BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0155.p (353 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2109 [GER] COG0697 Permeases of the drug/metabolite transport... 356 4e-98 ZyddG [GER] COG0697 Permeases of the drug/metabolite transporter... 303 4e-82 ECs2077 [GER] COG0697 Permeases of the drug/metabolite transport... 303 4e-82 yddG [GER] COG0697 Permeases of the drug/metabolite transporter ... 303 5e-82 STM1571 [GER] COG0697 Permeases of the drug/metabolite transport... 265 2e-70 VCA0835 [GER] COG0697 Permeases of the drug/metabolite transport... 205 1e-52 YPO3413 [GER] COG0697 Permeases of the drug/metabolite transport... 155 2e-37 >RSc2109 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 316 Score = 356 bits (914), Expect = 4e-98, Method: Compositional matrix adjust. Identities = 196/331 (59%), Positives = 231/331 (69%), Gaps = 32/331 (9%) Query: 1 MNSK-KATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRS 59 M SK KATL+GL AVVLWS+IVGL+RGVS LGA GGAA +YTV S LL +VG ++ + Sbjct: 1 MQSKRKATLIGLIAVVLWSSIVGLLRGVSASLGAVGGAAMMYTVVSIFLLFSVGFIKVNA 60 Query: 60 FPRRYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRAT 119 FPRRYL WGS+LFVSYELCLSLSIGYAN+ RQAIEVGMVNYLWPTFT+ AI F++Q + Sbjct: 61 FPRRYLVWGSILFVSYELCLSLSIGYANSDRQAIEVGMVNYLWPTFTMLFAIAFNRQPSN 120 Query: 120 WLMAPGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRM 179 L+ PG ++++LGIC VLGGDQGLD AGM NI+DNPLSYGLA +GALIWAAYC VT+RM Sbjct: 121 LLIIPGVLVAILGICQVLGGDQGLDFAGMAANIQDNPLSYGLALSGALIWAAYCAVTSRM 180 Query: 180 AAGMNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGIL 239 A G NG+T FFM+ A+ LW K LA G + S A++YL++AA AMG GYAAWNVGIL Sbjct: 181 AEGKNGITLFFMLTALALWIKYLATGG-GAMHFSYQAILYLVMAACAMGFGYAAWNVGIL 239 Query: 240 HGNVTVLAGASYFIPVFSSALSALALALAKRVLDRGRAGLRRLHPVLDRHPQGGAGVCPG 299 HGNVTVLAGASYFIPVFS+AL+A L P+ +G + VC G Sbjct: 240 HGNVTVLAGASYFIPVFSAALAATLLR----------------TPLSSAFWKGASMVCAG 283 Query: 300 RC--------------SSEPVAHAHPHHRIE 316 SS A H H RI Sbjct: 284 SILCWLATRGQRSTAPSSPERARWHAHERIH 314 >ZyddG [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 293 Score = 303 bits (776), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 152/266 (57%), Positives = 193/266 (72%), Gaps = 1/266 (0%) Query: 1 MNSKKATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSF 60 M +KATL+GL A+VLWS +VGLIRGVSE LG GGAAAIY+++ +L+ TVG PR+R Sbjct: 1 MTRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQI 60 Query: 61 PRRYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATW 120 P+ YL GSLLFVSYE+CL+LS+GYA T QAIEVGMVNYLWP+ T+ AILF+ Q+ W Sbjct: 61 PKGYLLAGSLLFVSYEICLALSLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNW 120 Query: 121 LMAPGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMA 180 L+ PG +L+++G+CWVLGGD GL ++ NI +PLSY LAF GA IWAAYCTVT + A Sbjct: 121 LIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFLAFIGAFIWAAYCTVTNKYA 180 Query: 181 AGMNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGILH 240 G NG+T F ++ LW E+ S P ++ L+ AA +G YAAWNVGILH Sbjct: 181 RGFNGITVFVLLTGASLWVYYFLTPQ-PEMVFSTPVMIKLISAAFTLGFAYAAWNVGILH 239 Query: 241 GNVTVLAGASYFIPVFSSALSALALA 266 GNVT++A SYF PV SSAL+A+ L+ Sbjct: 240 GNVTIMAVGSYFTPVLSSALAAVLLS 265 >ECs2077 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 293 Score = 303 bits (776), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 152/266 (57%), Positives = 193/266 (72%), Gaps = 1/266 (0%) Query: 1 MNSKKATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSF 60 M +KATL+GL A+VLWS +VGLIRGVSE LG GGAAAIY+++ +L+ TVG PR+R Sbjct: 1 MTRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQI 60 Query: 61 PRRYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATW 120 P+ YL GSLLFVSYE+CL+LS+GYA T QAIEVGMVNYLWP+ T+ AILF+ Q+ W Sbjct: 61 PKGYLLAGSLLFVSYEICLALSLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNW 120 Query: 121 LMAPGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMA 180 L+ PG +L+++G+CWVLGGD GL ++ NI +PLSY LAF GA IWAAYCTVT + A Sbjct: 121 LIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFLAFIGAFIWAAYCTVTNKYA 180 Query: 181 AGMNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGILH 240 G NG+T F ++ LW E+ S P ++ L+ AA +G YAAWNVGILH Sbjct: 181 RGFNGITVFVLLTGASLWVYYFLTPQ-PEMVFSTPVMIKLISAAFTLGFAYAAWNVGILH 239 Query: 241 GNVTVLAGASYFIPVFSSALSALALA 266 GNVT++A SYF PV SSAL+A+ L+ Sbjct: 240 GNVTIMAVGSYFTPVLSSALAAVLLS 265 >yddG [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Eco Escherichia coli K12 Length = 293 Score = 303 bits (775), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 152/266 (57%), Positives = 193/266 (72%), Gaps = 1/266 (0%) Query: 1 MNSKKATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSF 60 M +KATL+GL A+VLWS +VGLIRGVSE LG GGAAAIY+++ +L+ TVG PR+R Sbjct: 1 MTRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQI 60 Query: 61 PRRYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATW 120 P+ YL GSLLFVSYE+CL+LS+GYA T QAIEVGMVNYLWP+ T+ AILF+ Q+ W Sbjct: 61 PKGYLLAGSLLFVSYEICLALSLGYAATHHQAIEVGMVNYLWPSLTILFAILFNGQKTNW 120 Query: 121 LMAPGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMA 180 L+ PG +L+++G+CWVLGGD GL ++ NI +PLSY LAF GA IWAAYCTVT + A Sbjct: 121 LIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFLAFIGAFIWAAYCTVTNKYA 180 Query: 181 AGMNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGILH 240 G NG+T F ++ LW E+ S P ++ L+ AA +G YAAWNVGILH Sbjct: 181 RGFNGITVFVLLTGASLWVYYFLTPQ-PEMIFSTPVMIKLISAAFTLGFAYAAWNVGILH 239 Query: 241 GNVTVLAGASYFIPVFSSALSALALA 266 GNVT++A SYF PV SSAL+A+ L+ Sbjct: 240 GNVTIMAVGSYFTPVLSSALAAVLLS 265 >STM1571 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sty Salmonella typhimurium LT2 Length = 274 Score = 265 bits (676), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 132/236 (55%), Positives = 169/236 (71%), Gaps = 1/236 (0%) Query: 20 IVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSFPRRYLFWGSLLFVSYELCL 79 +VGLIRGVSE LG GGAA IY+++ +L+ TVG+P +R FP RYL GS+LFVSYE+CL Sbjct: 1 MVGLIRGVSEGLGPVGGAAMIYSLSGLLLIFTVGLPDIRRFPGRYLIAGSVLFVSYEICL 60 Query: 80 SLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATWLMAPGFVLSMLGICWVLGG 139 +LS+GYA T QAIEVGMVNYLWP+ T+ AILF+ Q+ WL+ PG ++++ G+CWVLGG Sbjct: 61 ALSLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLIALTGVCWVLGG 120 Query: 140 DQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMAAGMNGVTPFFMMVAVVLWG 199 + GL+ ++ N+ +PLSY LAF GA IWA YCTVT + A G NG+T F ++ AV LW Sbjct: 121 ENGLNPGEIISNVATSPLSYLLAFLGAFIWATYCTVTNKYARGFNGITVFVLLTAVALWL 180 Query: 200 KVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGILHGNVTVLAGASYFIPV 255 A + SLP + L AA +G YAAWNVGILHGNVT++A SYF PV Sbjct: 181 HYFLTPQPAMI-FSLPVIAKLFTAALTLGFAYAAWNVGILHGNVTIMAVGSYFTPV 235 >VCA0835 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 328 Score = 205 bits (522), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 112/263 (42%), Positives = 158/263 (60%), Gaps = 1/263 (0%) Query: 3 SKKATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSFPR 62 + K TL G+ A++LW +++ L R V+E GGAA IYTV++ LL +GMPRL++ Sbjct: 20 THKHTLYGVAAILLWGSLMALTRRVAEEFSPIGGAALIYTVSTLFLLFAMGMPRLKAGSS 79 Query: 63 RYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATWLM 122 RY+ G LFVSYE+CL+L++G A+ QAIE+ ++NYLWP T+ A+L S++ ++ + Sbjct: 80 RYILIGGALFVSYEICLALALGMASDRLQAIEMSVINYLWPALTVLIAVLLSQRAVSFWV 139 Query: 123 APGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMAAG 182 P L+ G+ W + +QG+ +A I NP Y +A GA IWA YC VT R+A G Sbjct: 140 YPSVGLAFAGVAWTIVAEQGISLADFSARIATNPAVYAMALTGAFIWAIYCNVTQRLARG 199 Query: 183 MNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGLGYAAWNVGILHGN 242 N + FF A LW + A LS + ++ LLL MG GYA WNV IL GN Sbjct: 200 QNAIVLFFAATAATLWLQYALSNEPA-LSFTGSSMGTLLLTGIVMGSGYALWNVAILRGN 258 Query: 243 VTVLAGASYFIPVFSSALSALAL 265 + +LA SYF PV S+ S+L L Sbjct: 259 MLLLATLSYFTPVISTLFSSLIL 281 >YPO3413 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 302 Score = 155 bits (391), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/262 (36%), Positives = 142/262 (54%), Gaps = 8/262 (3%) Query: 3 SKKATLVGLTAVVLWSAIVGLIRGVSEHLGATGGAAAIYTVASAILLVTVGMPRLRSFPR 62 ++ TL G+ A++LWS V L RG++E LG G +AIY+V+ ++ + G PR+R Sbjct: 2 NRLPTLYGIIAILLWSMSVALTRGLAEALGPFGAGSAIYSVSGILVWLVAGKPRVRGQHP 61 Query: 63 RYLFWGSLLFVSYELCLSLSIGYANTARQAIEVGMVNYLWPTFTLTAAILFSKQRATWLM 122 YL+ LLFV Y + +L+IG AN +Q +E+G++NYLWP+ TL A+ K RA W + Sbjct: 62 AYLYGCGLLFVVYMVAFALAIGMANDRQQTLEIGLINYLWPSLTLLLAVPLLKLRARWWL 121 Query: 123 APGFVLSMLGICWVLGGDQGLDVAGMLENIRDNPLSYGLAFAGALIWAAYCTVTTRMAAG 182 PG L++ G+ WV+ G +GLDV + NI NPL+Y LA A WA Y + + G Sbjct: 122 WPGAALALFGVIWVVSGGEGLDVKTLAVNISSNPLAYSLALIAAFTWAGYSNLVRLYSQG 181 Query: 183 MNGVTPFFMMVAVVLWGKVLAGGHLAELSMSLPALVYLLLAAAAMGL-------GYAAWN 235 + F + A+ LW +L + A+ LLL A L Y W+ Sbjct: 182 PGALPLFLIACALCLWLMFFMWTP-GKLHFTPRAIFELLLMGANTALAYQCWDRAYQCWD 240 Query: 236 VGILHGNVTVLAGASYFIPVFS 257 + GN T++A SYF P+ S Sbjct: 241 SAMKKGNATLVAALSYFTPLLS 262