BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0084.p (343 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3366 [R] COG0388 Predicted amidohydrolase Pae Pseudomonas aeru... 567 e-161 HP0294 [R] COG0388 Predicted amidohydrolase Hpy Helicobacter pyl... 541 e-154 jhp0279 [R] COG0388 Predicted amidohydrolase jHp Helicobacter py... 539 e-153 HP1238 [R] COG0388 Predicted amidohydrolase Hpy Helicobacter pyl... 219 8e-57 jhp1159 [R] COG0388 Predicted amidohydrolase jHp Helicobacter py... 214 3e-55 SPCC965.09 [R] COG0388 Predicted amidohydrolase Spo Schizosaccha... 96 1e-19 PA3598 [R] COG0388 Predicted amidohydrolase Pae Pseudomonas aeru... 80 7e-15 PAB1449 [R] COG0388 Predicted amidohydrolase Pab Pyrococcus abyssi 76 1e-13 MA4525 [R] COG0388 Predicted amidohydrolase Mac Methanosarcina a... 73 8e-13 PH0642 [R] COG0388 Predicted amidohydrolase Pho Pyrococcus horik... 70 6e-12 >PA3366 [R] COG0388 Predicted amidohydrolase Pae Pseudomonas aeruginosa Length = 346 Score = 567 bits (1461), Expect = e-161, Method: Compositional matrix adjust. Identities = 264/340 (77%), Positives = 295/340 (86%) Query: 1 MRHGDISSSKDAVGVAVVNYKMPRLHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEY 60 MRHGDISSS D VGVAVVNYKMPRLHT EVL+NA+KIA M+VGMKQGLPG+DLVVFPEY Sbjct: 1 MRHGDISSSNDTVGVAVVNYKMPRLHTAAEVLDNARKIAEMIVGMKQGLPGMDLVVFPEY 60 Query: 61 STHGIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPRKVPYNTLI 120 S GIMYD EM ETA AIPG+ET IFS ACR A VWGVFSLTGERHEEHPRK PYNTL+ Sbjct: 61 SLQGIMYDPAEMMETAVAIPGEETEIFSRACRKANVWGVFSLTGERHEEHPRKAPYNTLV 120 Query: 121 LINDQGEIVQKYRKIMPWTPIEGWYPGDATYVCDGPKGLKISLIICDDGNYPEIWRDCAM 180 LI++ GEIVQKYRKI+PW PIEGWYPG TYV +GPKG+KISLIICDDGNYPEIWRDCAM Sbjct: 121 LIDNNGEIVQKYRKIIPWCPIEGWYPGGQTYVSEGPKGMKISLIICDDGNYPEIWRDCAM 180 Query: 181 KGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDG 240 KGAEL+VRCQGYMYPAK+QQ+M++KAMAW NN YVAVANAAGFDGVYSYFGHSAI+GFDG Sbjct: 181 KGAELIVRCQGYMYPAKDQQVMMAKAMAWANNCYVAVANAAGFDGVYSYFGHSAIIGFDG 240 Query: 241 RTLGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYKLLHRGYTGKINSGESPAGVAEC 300 RTLGECG EEMGIQYA+LS+S IRDAR N QSQNHL+K+LHRGY+G SG+ G+AEC Sbjct: 241 RTLGECGEEEMGIQYAQLSLSQIRDARANDQSQNHLFKILHRGYSGLQASGDGDRGLAEC 300 Query: 301 PFDFYRTWVNDPQAARAQVEALTRNSAGTPECPMPGIPIE 340 PF+FYRTWV D + AR VE LTR++ G +CP+ +P E Sbjct: 301 PFEFYRTWVTDAEKARENVERLTRSTTGVAQCPVGRLPYE 340 >HP0294 [R] COG0388 Predicted amidohydrolase Hpy Helicobacter pylori 26695 Length = 339 Score = 541 bits (1395), Expect = e-154, Method: Compositional matrix adjust. Identities = 249/340 (73%), Positives = 290/340 (85%), Gaps = 1/340 (0%) Query: 1 MRHGDISSSKDAVGVAVVNYKMPRLHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEY 60 MRHGDISSS D VGVAVVNYKMPRLHT+ EVLEN + IA ++ G+KQGLPGLDL++FPEY Sbjct: 1 MRHGDISSSPDTVGVAVVNYKMPRLHTKNEVLENCRNIAKVIGGVKQGLPGLDLIIFPEY 60 Query: 61 STHGIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPRKVPYNTLI 120 STHGIMYDR+EMF+TAA++PG+ET IF+EAC+ VWGVFSLTGE+HE+ +K PYNTLI Sbjct: 61 STHGIMYDRQEMFDTAASVPGEETAIFAEACKKNKVWGVFSLTGEKHEQ-AKKNPYNTLI 119 Query: 121 LINDQGEIVQKYRKIMPWTPIEGWYPGDATYVCDGPKGLKISLIICDDGNYPEIWRDCAM 180 L+ND+GEIVQKYRKI+PW PIE WYPGD TYV DGPKGLK+SLIICDDGNYPEIWRDCAM Sbjct: 120 LVNDKGEIVQKYRKILPWCPIECWYPGDKTYVVDGPKGLKVSLIICDDGNYPEIWRDCAM 179 Query: 181 KGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDG 240 +GAEL+VRCQGYMYPAKEQQI + KAMAW N YVAVANA GFDGVYSYFGHS+I+GFDG Sbjct: 180 RGAELIVRCQGYMYPAKEQQIAIVKAMAWANQCYVAVANATGFDGVYSYFGHSSIIGFDG 239 Query: 241 RTLGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYKLLHRGYTGKINSGESPAGVAEC 300 TLGECG EE G+QYA+LS+ IRDAR+ QSQN L+KLLHRGY+G SG+ GVAEC Sbjct: 240 HTLGECGEEENGLQYAQLSVQQIRDARKYDQSQNQLFKLLHRGYSGVFASGDGDKGVAEC 299 Query: 301 PFDFYRTWVNDPQAARAQVEALTRNSAGTPECPMPGIPIE 340 PF+FY+TWVNDP+ A+ VE +TR S G CP+ +P + Sbjct: 300 PFEFYKTWVNDPKKAQENVEKITRPSVGVAACPVGDLPTK 339 >jhp0279 [R] COG0388 Predicted amidohydrolase jHp Helicobacter pylori J99 Length = 339 Score = 539 bits (1388), Expect = e-153, Method: Compositional matrix adjust. Identities = 248/340 (72%), Positives = 288/340 (84%), Gaps = 1/340 (0%) Query: 1 MRHGDISSSKDAVGVAVVNYKMPRLHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEY 60 MRHGDISSS D VGVAVVNYKMPRLHT+ EVLEN + IA ++ G+KQGLPGLDL++FPEY Sbjct: 1 MRHGDISSSPDTVGVAVVNYKMPRLHTKNEVLENCRNIAKVIGGVKQGLPGLDLIIFPEY 60 Query: 61 STHGIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPRKVPYNTLI 120 STHGIMYDR+EMF+TAA++PG+ET I +EAC+ VWGVFSLTGE+HE+ +K PYNTLI Sbjct: 61 STHGIMYDRQEMFDTAASVPGEETAILAEACKKNKVWGVFSLTGEKHEQ-AKKNPYNTLI 119 Query: 121 LINDQGEIVQKYRKIMPWTPIEGWYPGDATYVCDGPKGLKISLIICDDGNYPEIWRDCAM 180 L+ND+GEIVQKYRKI+PW PIE WYPGD TYV DGPKGLK+SLIICDDGNYPEIWRDCAM Sbjct: 120 LVNDKGEIVQKYRKILPWCPIECWYPGDKTYVVDGPKGLKVSLIICDDGNYPEIWRDCAM 179 Query: 181 KGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDG 240 +GAEL+VRCQGYMYPAKEQQI + KAMAW N YVAVANA GFDGVYSYFGHS+I+GFDG Sbjct: 180 RGAELIVRCQGYMYPAKEQQIAIVKAMAWANQCYVAVANATGFDGVYSYFGHSSIIGFDG 239 Query: 241 RTLGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYKLLHRGYTGKINSGESPAGVAEC 300 TLGECG EE G+QYA+LS+ IRDAR+ QSQN L+KLLHRGY+G SG+ GVAEC Sbjct: 240 HTLGECGEEENGLQYAQLSVQQIRDARKYDQSQNQLFKLLHRGYSGVFASGDGDKGVAEC 299 Query: 301 PFDFYRTWVNDPQAARAQVEALTRNSAGTPECPMPGIPIE 340 PF+FY+TWVNDP+ A+ VE TR S G CP+ +P + Sbjct: 300 PFEFYKTWVNDPKKAQENVEKFTRPSVGVAACPVGDLPTK 339 >HP1238 [R] COG0388 Predicted amidohydrolase Hpy Helicobacter pylori 26695 Length = 334 Score = 219 bits (558), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 116/296 (39%), Positives = 171/296 (57%), Gaps = 4/296 (1%) Query: 4 GDISSSKDAVGVAVVNYKMPRLHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEYSTH 63 G + + VA + + +P +++R ++ N + I L K G PG++L++FPEYST Sbjct: 5 GSMGKPIEGFLVAAIQFPVPIVNSRKDIDHNIESIIRTLHATKAGYPGVELIIFPEYSTQ 64 Query: 64 GIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPRKVPYNTLILIN 123 G+ + E +PG ET ++++AC+ A V+GVFS+ ER+ + K PYNT I+I+ Sbjct: 65 GLNTAKWLSEEFLLDVPGKETELYAKACKEAKVYGVFSIM-ERNPDS-NKNPYNTAIIID 122 Query: 124 DQGEIVQKYRKIMPWTPIEGWYPGDATY-VCDGPKGLKISLIICDDGNYPEIWRDCAMKG 182 QGEI+ KYRK+ PW PIE WYPGD VC+GP G K+++ IC DG PE+ R+ A KG Sbjct: 123 PQGEIILKYRKLFPWNPIEPWYPGDLGMPVCEGPGGSKLAVCICHDGMIPELAREAAYKG 182 Query: 183 AELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDGRT 242 + +R GY +Q I+ +++ AW N +Y N AG+D V+ YFG I FDG T Sbjct: 183 CNVYIRISGYSTQVNDQWILTNRSNAWHNLMYTVSVNLAGYDNVFYYFGEGQICNFDGTT 242 Query: 243 LGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYKLLHRGYTGKINSGESPAGVA 298 L + I E+ +AR +W +N++Y L HRGY K GE AG+ Sbjct: 243 LVQGHRNPWEIVTGEIYPKMADNARLSWGLENNIYNLGHRGYVAK-PGGEHDAGLT 297 >jhp1159 [R] COG0388 Predicted amidohydrolase jHp Helicobacter pylori J99 Length = 334 Score = 214 bits (544), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 113/296 (38%), Positives = 170/296 (57%), Gaps = 4/296 (1%) Query: 4 GDISSSKDAVGVAVVNYKMPRLHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEYSTH 63 G + + VA + + +P +++R ++ N + I L K G PG++L++FPEYST Sbjct: 5 GSMGKPIEGFLVAAIQFPVPIVNSRKDIDHNIESIIRTLHATKAGYPGVELIIFPEYSTQ 64 Query: 64 GIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPRKVPYNTLILIN 123 G+ + E +PG ET ++++AC+ A V+GV S+ ER+ + + PYNT I+I+ Sbjct: 65 GLNTAKWLSEEFLLDVPGKETELYAKACKEAKVYGVLSIM-ERNPDS-NENPYNTAIIID 122 Query: 124 DQGEIVQKYRKIMPWTPIEGWYPGDATY-VCDGPKGLKISLIICDDGNYPEIWRDCAMKG 182 QG+I+ KYRK+ PW PIE WYPGD VC+GP G K+++ IC DG PE+ R+ A KG Sbjct: 123 PQGKIILKYRKLFPWNPIEPWYPGDLGMPVCEGPGGSKLAVCICHDGMIPELAREAAYKG 182 Query: 183 AELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDGRT 242 + +R GY +Q I+ +++ AW N +Y N AG+D V+ YFG I FDG T Sbjct: 183 CNVYIRISGYSTQVNDQWILTNRSNAWHNLMYTVSVNLAGYDNVFYYFGEGQICNFDGTT 242 Query: 243 LGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYKLLHRGYTGKINSGESPAGVA 298 L + I E+ +AR +W +N++Y L HRGY K GE AG+ Sbjct: 243 LVQGHRNPWEIVTGEIYPKMADNARLSWGLENNIYNLGHRGYVAK-PGGEHDAGLT 297 >SPCC965.09 [R] COG0388 Predicted amidohydrolase Spo Schizosaccharomyces pombe Length = 272 Score = 95.9 bits (237), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/245 (26%), Positives = 116/245 (47%), Gaps = 4/245 (1%) Query: 29 CEVLENAQKIAAMLVGMKQGLPGLDLVVFPEYSTHGIMYDREEMFETAAAIPGDETRIFS 88 C+V N QK+++ + + + P +L++FPE T G Y+ F A I G E F Sbjct: 15 CDVKHNLQKMSSYVHEVMESNPSTNLILFPELITSG--YECGNTFTQIAEIAG-EGPSFK 71 Query: 89 EACRIAGVWGVFSLTG-ERHEEHPRKVPYNTLILINDQGEIVQKYRKIMPWTPIEGWYPG 147 +A + V + G EE + YN+ I I + G + YRK+ + + Sbjct: 72 TMSNLAAKYHVNIIYGFPEKEEKQSNIIYNSCIYITENGNLGGVYRKVHLFDTERKHFKK 131 Query: 148 DATYVCDGPKGLKISLIICDDGNYPEIWRDCAMKGAELVVRCQGYMYPAKEQQIMVSKAM 207 + + K+ ++IC D +PE+ R A+ GA+L+V + P + +V+KA Sbjct: 132 GSDFPIFETSFGKLGVMICWDTAFPEVARIHALNGADLLVVATNWENPYSDDWDLVTKAR 191 Query: 208 AWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDGRTLGECGTEEMGIQYAELSISAIRDAR 267 A+ N + + AN G D S+FGHS I+G G+ + E+ G+ + + + R Sbjct: 192 AFENCIPLVAANRVGTDEKLSFFGHSKIIGPTGKVIKALDEEKEGVISYTVDLDDAKPLR 251 Query: 268 RNWQS 272 +N+ + Sbjct: 252 KNYYT 256 >PA3598 [R] COG0388 Predicted amidohydrolase Pae Pseudomonas aeruginosa Length = 271 Score = 80.1 bits (196), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 75/221 (33%), Positives = 101/221 (45%), Gaps = 11/221 (4%) Query: 53 DLVVFPEYSTHGIMYDREEMFETAAAIPGDETRIFSEACRIAGVWGVFSLTGERHEEHPR 112 +LVVFPE TH + E+ A A P D + S R+A V G + R Sbjct: 34 ELVVFPE--THLTGFPSEDNI-AALAEPLDGPTV-SAVQRVARERNVSVAIGIAEADAGR 89 Query: 113 KVPYNTLILINDQGEIVQKYRKIMPWTPIEGWY-PGDATYVCDGPKGLKISLIICDDGNY 171 YNT +LI G I KYRK W G + PGD Y G+++ L++C D + Sbjct: 90 Y--YNTTLLIAPDG-IALKYRKTHLWASDRGIFTPGD-RYATALWNGIRVGLLVCFDIEF 145 Query: 172 PEIWRDCAMKGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGF-DGVYSYF 230 PE R GAEL++ G M P A A N Y + N G DG + Sbjct: 146 PESARALGQLGAELIIVTNGNMDPYGPTHRTAIMARAMENQAYAVMVNRVGHGDGGLVFA 205 Query: 231 GHSAIVGFDGRTLGECGTEEMGIQYAELSISAIRDARRNWQ 271 G SA+V G+ L E G EE Q EL + ++DARR+++ Sbjct: 206 GGSAVVDPYGQLLCEAGREECR-QIVELDLGRLQDARRDYR 245 >PAB1449 [R] COG0388 Predicted amidohydrolase Pab Pyrococcus abyssi Length = 262 Score = 76.3 bits (186), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 108/231 (46%), Gaps = 14/231 (6%) Query: 51 GLDLVVFPEYSTHGIMYD-REEMFETAAAIP-GDETRIFSEACRIAGVWGVFSLTGERHE 108 G LVV PE G ++ REE+FE A IP G+ T + R GV+ + + T E+ Sbjct: 34 GAQLVVLPELFDTGYNFETREEVFEIAQKIPEGETTTFLMDVARDTGVY-IVAGTAEKDG 92 Query: 109 EHPRKVPYNTLILINDQGEIVQKYRKIMPWTPIEGWY-PGDATYVCDGPKGLKISLIICD 167 + V YN+ +++ +G + KYRKI + + ++ PGD + +K+ ++IC Sbjct: 93 D----VLYNSAVVVGPRG-FIGKYRKIHLFYREKFFFEPGDLGFRVFDLGFMKVGVMICF 147 Query: 168 DGNYPEIWRDCAMKGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVY 227 D +PE R A+KGA+++ + P + + + A N +Y A+ G + Sbjct: 148 DWFFPESARTLALKGADVIAHPANLVMPYAPRAMPIR---ALENKVYTVTADRVGEERGL 204 Query: 228 SYFGHSAIVGFDGRTLGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYK 278 + G S I L E + AE+ + +R+ R N N ++K Sbjct: 205 KFIGKSLIASPKAEVLSMASETEEEVGVAEIDLYLVRNKRIN--DLNDIFK 253 >MA4525 [R] COG0388 Predicted amidohydrolase Mac Methanosarcina acetivorans str.C2A Length = 270 Score = 73.2 bits (178), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 122/259 (47%), Gaps = 30/259 (11%) Query: 25 LHTRCEVLENAQKIAAMLVGMKQGLPGLDLVVFPEYSTHGIMYDR-EEMFETAAAIPGDE 83 L ++ E LE A +A V + +L+VFPE + G YDR ++ ET + + Sbjct: 16 LCSKQENLERALSLAEEAVSREA-----ELLVFPEVFSTGFCYDRIGDVAETTSGPTLET 70 Query: 84 TRIFSE--ACRIAGVWGVFSLTGERHEEHP---RKVP--YNTLILINDQGEIVQKYRKIM 136 R FS C +AG S+ R + P +KVP YN I + G++ RK+ Sbjct: 71 LRAFSREHGCILAG-----SMIEIREGDAPGSEKKVPSQYNLGFCI-ESGKLAGIRRKVQ 124 Query: 137 PWTPIEGWY-PGDATYVCDGPK-GLKISLIICDDGNYPEIWRDCAMKGAELVVRCQG--- 191 + P + ++ GD+ K GL I LI+C++ YPE+ R ++GA+L+V Sbjct: 125 LYGPEKEYFASGDSISPIKLQKYGLSIGLIVCNELRYPEVARKLVLEGADLLVSAADIPD 184 Query: 192 -YMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVYSYFGHSAIVGFDGRTLGECGTEE 250 Y+YP + ++S + A N L N G D Y G S IV GR L E GTEE Sbjct: 185 FYIYPWR----IMSFSRAIENQLPHIACNRVGKDRYSIYPGGSFIVDGWGRVLAEAGTEE 240 Query: 251 MGIQYAELSISAIRDARRN 269 + E+ + ++ R+ Sbjct: 241 C-VLLGEIDLVKAKELRQT 258 >PH0642 [R] COG0388 Predicted amidohydrolase Pho Pyrococcus horikoshii Length = 262 Score = 70.5 bits (171), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 105/231 (45%), Gaps = 14/231 (6%) Query: 51 GLDLVVFPEYSTHGIMYD-REEMFETAAAIP-GDETRIFSEACRIAGVWGVFSLTGERHE 108 G LVV PE G ++ REE+F+ A IP G+ T E R G++ + + T E+ Sbjct: 34 GAKLVVLPELFDTGYNFESREEVFDVAQQIPEGETTTFLMELARELGLY-IVAGTAEKSG 92 Query: 109 EHPRKVPYNTLILINDQGEIVQKYRKIMPWTPIEGWY-PGDATYVCDGPKGLKISLIICD 167 + YN+ +++ +G I KYRKI + + ++ PGD + K+ ++IC Sbjct: 93 NYL----YNSAVVVGPRGYI-GKYRKIHLFYREKVFFEPGDLGFKVFDIGFAKVGVMICF 147 Query: 168 DGNYPEIWRDCAMKGAELVVRCQGYMYPAKEQQIMVSKAMAWMNNLYVAVANAAGFDGVY 227 D +PE R A+KGAE++ + P + + + A N +Y A+ G + Sbjct: 148 DWFFPESARTLALKGAEIIAHPANLVMPYAPRAMPIR---ALENRVYTITADRVGEERGL 204 Query: 228 SYFGHSAIVGFDGRTLGECGTEEMGIQYAELSISAIRDARRNWQSQNHLYK 278 + G S I L E I E+ ++ R+ R N N ++K Sbjct: 205 KFIGKSLIASPKAEVLSIASETEEEIGVVEIDLNLARNKRLN--DMNDIFK 253