BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0032.p (266 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC0801 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Vc... 135 1e-31 STM0619 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase S... 123 5e-28 citG [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Eco ... 122 8e-28 ZcitG [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase EcZ... 120 3e-27 ECs0652 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase E... 120 3e-27 STM0063 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase S... 117 2e-26 SPy1178 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase S... 110 2e-24 PA0209 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Pa... 106 4e-23 HI0021_2 Non COG 106 5e-23 FN1377 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Fn... 101 2e-21 >VC0801 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Vch Vibrio cholerae Length = 313 Score = 135 bits (339), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 89/265 (33%), Positives = 133/265 (50%), Gaps = 8/265 (3%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYFFQIAVAGLK--GAP----FHHLQKL 55 L PKPGLV +NG+H DMD +TF+ S ++ Y AG + G P L+ + Sbjct: 46 LTPKPGLVDTANNGAHRDMDLNTFIASAEAIAPYLHSFVSAGWESAGNPAAQLLSALRPI 105 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 I AE M AT GVNTH+G IF LG++C ++ + + +L + A+ I T I+ Sbjct: 106 GIEAEQAMFAATQGVNTHKGMIFILGLICGSVGWLKANQLKIDAQHIGET--IRQACQFL 163 Query: 116 RHSGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPHE 175 + R + G+ + + + GAR E A G V + ALP Q+ L +G + + Sbjct: 164 VIDELKAKRDCEPETAGERIYRQYGLTGARGEAASGLAMVMQHALPAYQACLTKGASTEQ 223 Query: 176 ARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDFV 235 A L LMA+ +D+N+ RGG G V++Q+ L GG A + Sbjct: 224 ALWHTLLVLMANNNDSNLVSRGGLAGLHFVQEQAQQLLAKGGFLYQEIEQALTALDSVLI 283 Query: 236 AHRLSPGGAADLLAAACLVHQAMAL 260 LSPGG+ADLLAA L+++ + L Sbjct: 284 EKHLSPGGSADLLAATWLIYELVQL 308 >STM0619 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Sty Salmonella typhimurium LT2 Length = 298 Score = 123 bits (308), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 101/265 (38%), Positives = 138/265 (52%), Gaps = 18/265 (6%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHY---FFQIAVAGLKGAP---FHHLQKL 55 L PKPGLV ++ G+H DM + F RS ++RH+ F + + + P L+ L Sbjct: 36 LSPKPGLVDRLNCGAHKDMALADFHRSAEAIRHWLPRFMEYGASCTRLPPESVLAGLRPL 95 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 +A EA M RAT GVNTH+G+IF+LG+LCAA+ R P+ AE + AT D Sbjct: 96 GMACEAAMFRATAGVNTHKGSIFSLGLLCAAIGRLYQLRQPIAAETLCATA----ADFCR 151 Query: 116 RHSGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPHE 175 + L + Q + GQ + + GAR E G+P V ALP ++ LAQGR P Sbjct: 152 GLTTRELRQNNLQLTAGQRLYQQLGLTGARGEAEAGYPLVIRHALPHYRALLAQGRDPEL 211 Query: 176 ARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDF- 234 A +D L LM+ DTNV RGGA+G + ++QQ+A L GG L H F Sbjct: 212 ALLDTLLLLMSLNGDTNVASRGGADGLRWLQQQAAVLLQQGGIRTP----DDLVYLHRFD 267 Query: 235 ---VAHRLSPGGAADLLAAACLVHQ 256 + LSPGG+ADLL + Q Sbjct: 268 QQCIERNLSPGGSADLLIVTWFLAQ 292 >citG [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Eco Escherichia coli K12 Length = 292 Score = 122 bits (306), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 91/261 (34%), Positives = 125/261 (47%), Gaps = 10/261 (3%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHY---FFQIAVAGLKGAP---FHHLQKL 55 L PKPGLV I+ G+H DM F RS +++ + F + + AP H L+ + Sbjct: 35 LSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPI 94 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 +A E M RAT GVNTH+G+IF+LG+LCAA+ GR L L V T+ Sbjct: 95 GMACEGDMFRATAGVNTHKGSIFSLGLLCAAI----GRLLQLNQPVTPTTVCSTAASFCR 150 Query: 116 RHSGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPHE 175 + L Q + GQ + + GAR E G+P V ALP + L QG P Sbjct: 151 GLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPEL 210 Query: 176 ARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDFV 235 A +D L LMA DTNV RGG G + +++++ L GG + + Sbjct: 211 ALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECI 270 Query: 236 AHRLSPGGAADLLAAACLVHQ 256 LSPGG+ADLL + Q Sbjct: 271 ERNLSPGGSADLLILTWFLAQ 291 >ZcitG [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase EcZ Escherichia coli O157:H7 EDL933 Length = 292 Score = 120 bits (301), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 91/262 (34%), Positives = 129/262 (49%), Gaps = 12/262 (4%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHY---FFQIAVAGLKGAP---FHHLQKL 55 L PKPGLV I+ G+H DM F RS +++ + F + + AP H L+ + Sbjct: 35 LSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPI 94 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 +A E M RAT GVNTH+G+IF+LG+LCAA+ GR L L +++ T + + Sbjct: 95 GMACEGDMFRATAGVNTHKGSIFSLGLLCAAI----GRLLQLN-QLLTPTTVCSTAASFC 149 Query: 116 RH-SGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPH 174 R + L Q + GQ + + GAR E G+P V ALP + L QG P Sbjct: 150 RGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPE 209 Query: 175 EARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDF 234 A +D L LMA DTNV RGG G + +++++ L GG + Sbjct: 210 LALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDREC 269 Query: 235 VAHRLSPGGAADLLAAACLVHQ 256 + LSPGG+ADLL + Q Sbjct: 270 IERNLSPGGSADLLILTWFLAQ 291 >ECs0652 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Ecs Escherichia coli O157:H7 Length = 292 Score = 120 bits (301), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 91/262 (34%), Positives = 129/262 (49%), Gaps = 12/262 (4%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHY---FFQIAVAGLKGAP---FHHLQKL 55 L PKPGLV I+ G+H DM F RS +++ + F + + AP H L+ + Sbjct: 35 LSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPI 94 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 +A E M RAT GVNTH+G+IF+LG+LCAA+ GR L L +++ T + + Sbjct: 95 GMACEGDMFRATAGVNTHKGSIFSLGLLCAAI----GRLLQLN-QLLTPTTVCSTAASFC 149 Query: 116 RH-SGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPH 174 R + L Q + GQ + + GAR E G+P V ALP + L QG P Sbjct: 150 RGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPE 209 Query: 175 EARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDF 234 A +D L LMA DTNV RGG G + +++++ L GG + Sbjct: 210 LALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDREC 269 Query: 235 VAHRLSPGGAADLLAAACLVHQ 256 + LSPGG+ADLL + Q Sbjct: 270 IERNLSPGGSADLLILTWFLAQ 291 >STM0063 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Sty Salmonella typhimurium LT2 Length = 302 Score = 117 bits (293), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 91/264 (34%), Positives = 127/264 (48%), Gaps = 19/264 (7%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYFFQIAVAGLKGAPFH------HLQKL 55 L PKPGLV + ++G+H DMD + F RS ++ + + + G A L+ L Sbjct: 36 LTPKPGLVDIRNSGAHRDMDLAAFERSTTAIAPWMEKFFIMGNNTAALAAENVLVMLRPL 95 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 +A E ML+AT GVNTHRGAIFA G+L AA+ R PL+ I D +A Sbjct: 96 GMACENDMLQATNGVNTHRGAIFAFGLLSAAIGRLLARGEPLEQNRI--------CDQVA 147 Query: 116 RHSGVHLD-----RGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQG 170 R S + + AG+ + ++ + + GAR E GF V ALP + + Sbjct: 148 RLSRNIVAHELSAKKAGKLTKSETHFQCYGLSGARGEAESGFRTVRTQALPVFNRVVQEH 207 Query: 171 RAPHEARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALAC 230 H A + L LMA DTN+ RGG EG V+QQ+ L GG G + Sbjct: 208 DDTHLALLQTLLHLMAWNDDTNLVSRGGLEGLYYVQQQAQKLLWQGGVLVEGGIEAMQSL 267 Query: 231 HHDFVAHRLSPGGAADLLAAACLV 254 + + LSPGG+ADLLA + Sbjct: 268 DDELILRNLSPGGSADLLAVTWFL 291 >SPy1178 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Spy Streptococcus pyogenes M1 GAS Length = 294 Score = 110 bits (276), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 83/266 (31%), Positives = 127/266 (47%), Gaps = 24/266 (9%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYF---FQIAVAGLKGAP---FHHLQKL 55 L PKPGLV DNG+HDDM TF+ S+ +L +F + A K P F+ L++L Sbjct: 23 LSPKPGLVDRFDNGAHDDMSFITFIDSMIALSPFFQAYIETGFAYAKEEPLLLFNRLRQL 82 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALA 115 AE M AT G+NTH+G F++ +L A R L ++ R D LA Sbjct: 83 GQKAEETMFCATQGINTHKGLNFSMALLLGATGAYLARTPHLMTDLGR----FSKEDTLA 138 Query: 116 -----RHSGVHL---DRG----AGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQL 163 + HL D G + ++G+ + + + + G R E + GF + + ALP Sbjct: 139 ICRLVKPMTAHLIQTDLGHLNTKKEFTYGEQLFVTYGIKGPRGEASEGFTTLTDHALPYF 198 Query: 164 QSTLAQGRAPHEARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGW 223 + ++Q P +++ L LM+ + D N+ HRGG E + V+ L+ + Sbjct: 199 RQMISQND-PETSQLRLLVYLMSIVEDGNLIHRGGIEAWKGVK-ADMRLLLQQDLSTTDL 256 Query: 224 RAQALACHHDFVAHRLSPGGAADLLA 249 R + + + LSPGGAADLLA Sbjct: 257 RLALSSYNQCLINQHLSPGGAADLLA 282 >PA0209 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Pae Pseudomonas aeruginosa Length = 293 Score = 106 bits (265), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 100/257 (38%), Positives = 123/257 (47%), Gaps = 17/257 (6%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYFFQIAVAGLKGAPFHH-----LQKLA 56 L PKP LV NG+H D+ S SL F ++A A + L +L Sbjct: 33 LSPKPALVDRRGNGAHADLHLGLMQASALSLWPCFKEMADAAQRHGRIDARLRGVLGQLG 92 Query: 57 IAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALAR 116 EA MLR T GVNTHRGAI+ALG+L AA A RR RA + D A Sbjct: 93 RDGEAAMLRTTEGVNTHRGAIWALGLLVAAAAL-EPRRTQAGEVAARAGRIALLDDPAA- 150 Query: 117 HSGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPHEA 176 A SHG+ V + VGGAREE L FP LPQL + G A Sbjct: 151 ---------AIGDSHGERVRRRYGVGGAREEARLCFPRAVRHGLPQLWRSREGGAGEQNA 201 Query: 177 RIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGASGWRAQALACHHDFVA 236 R+DAL A+M+ + DT V HR G G ++ + A L AGG+ + R + +A Sbjct: 202 RLDALLAIMSVLDDTCVLHRAGRVGLAAMQDGARAVLAAGGSASLAGRRRLCELDRRLLA 261 Query: 237 HRLSPGGAADLLAAACL 253 SPGGAADLL AACL Sbjct: 262 LNASPGGAADLL-AACL 277 >HI0021_2 Non COG Length = 281 Score = 106 bits (265), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 87/264 (32%), Positives = 125/264 (47%), Gaps = 24/264 (9%) Query: 2 LYPKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYFFQIAVAGLKGA------PFHHLQKL 55 L PKPGLV I+NGSH DM+ TF +S SL+ +F Q + G+ A ++ L Sbjct: 15 LSPKPGLVDAINNGSHKDMNLHTFEQSAISLKPFFTQFVLKGMMTAHLSENQILSEIRPL 74 Query: 56 AIAAEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEV-----IRATLLIQW 110 + AE M + T GVNTH+GAIF+ G++C A+ ++ +Q+ V + +L+ Q+ Sbjct: 75 GLLAEKAMFKVTDGVNTHKGAIFSFGLVCTAIGRLLAQKSLVQSAVDFDVKLICSLVAQF 134 Query: 111 GDALA---RHSGVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTL 167 L ++ HL AG R + + + G R E GF + + LPQ Sbjct: 135 TQGLTDELKNYPEHLPSTAGVRLFQK-----YGLTGVRGEAENGFNLI-QTLLPQFDE-Y 187 Query: 168 AQGRAPHEARIDALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAG--GTGASGWRA 225 Q H I L LMA SDTNV HRGG G ++Q + L T + Sbjct: 188 HQLEWEHRLLILLL-NLMAINSDTNVVHRGGLAGLYFIQQTAQDLLTDQHLVTDKTALTQ 246 Query: 226 QALACHHDFVAHRLSPGGAADLLA 249 + + LS GG+ADLLA Sbjct: 247 ALMKFDTACIERNLSSGGSADLLA 270 >FN1377 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase Fnu Fusobacterium nucleatum Length = 279 Score = 101 bits (252), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 118/259 (45%), Gaps = 13/259 (5%) Query: 4 PKPGLVSLIDNGSHDDMDASTFLRSLFSLRHYFFQIAVAGLKG---AP--FHHLQKLAIA 58 PK GLVS + NGSH DMD TF+ S+ SL +YF + G + +P F +L+ L Sbjct: 24 PKAGLVSRLSNGSHKDMDFYTFIDSVLSLSYYFSECYTYGQENNFYSPNFFKNLRDLGKK 83 Query: 59 AEARMLRATGGVNTHRGAIFALGMLCAAMAYCRGRRLPLQAEVIRATLLIQWGDALARHS 118 AE M +AT GVNTH+G IF++G+L + +A L + + I +L Q + Sbjct: 84 AEKEMYQATNGVNTHKGTIFSMGILISVLA----SHLK-EVDKIDLKILSQKIKNMCSSL 138 Query: 119 GVHLDRGAGQRSHGQSVALAHAVGGAREEGALGFPAVFEVALPQLQSTLAQGRAPHEARI 178 L+ ++G+ + + GAR G+ V + +L+ + + I Sbjct: 139 IDELENINNFSTYGEKAFKNYHLTGARGLALSGYDIVLLDGINKLKE-FTKSLDFETSCI 197 Query: 179 DALFALMAHISDTNVYHRGGAEGAQRVRQQSAAFLVAGGTGAS--GWRAQALACHHDFVA 236 LF ++ + DTN+ +R E + ++ S R + + F+ Sbjct: 198 LLLFYYISLLDDTNIVNRTNFETLKEIQILCKNLYEENVKSLSKEKIRNEMSKLNDIFIE 257 Query: 237 HRLSPGGAADLLAAACLVH 255 +S GG+ADLL +H Sbjct: 258 KNISAGGSADLLILTIFIH 276