BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0040.p (505 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_argH [E] COG0165 Argininosuccinate lyase Bsu Bacillus subtilis 169 1e-41 MJ0791 [E] COG0165 Argininosuccinate lyase Mja Methanococcus jan... 167 6e-41 lin2196 [E] COG0165 Argininosuccinate lyase Lin Listeria innocua 151 3e-36 MA1318 [E] COG0165 Argininosuccinate lyase Mac Methanosarcina ac... 149 2e-35 BH3186 [E] COG0165 Argininosuccinate lyase Bha Bacillus halodurans 148 3e-35 >BS_argH [E] COG0165 Argininosuccinate lyase Bsu Bacillus subtilis Length = 461 Score = 169 bits (428), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 114/394 (28%), Positives = 197/394 (50%), Gaps = 28/394 (7%) Query: 84 ITFEPLLIQAAGPQITLLHAGRSSQDMLATLRAAILREDLLTLANQLNATTAALVRLAAS 143 + E +LI GP LH GRS D +AT L+ + + + A +AL+ A + Sbjct: 86 LNIEKMLIDEIGPLGGKLHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEA 145 Query: 144 QRDTIVPNYTNGVAAQPNSYGHYLLGFAAALDRDAQRLREAYGRLDRSAMGTTVLNGTSW 203 +TI+P YT+ AQP S+ H+LL + L+RD +R +++ R+++S +G L GT++ Sbjct: 146 NVETILPGYTHLQRAQPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTF 205 Query: 204 PLNRQRMADYLGFAAIVDNAYDAAQLSAVDGPVEAGAVVSSIALHAGAFIQDVMTQYAQP 263 P++R A+ LGF AI +N+ D +S D +E + S + +H F ++++ +Q Sbjct: 206 PIDRDYSAELLGFDAIYENSLDG--VSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQE 263 Query: 264 RPWILLQEGGANTYV--SSAMPQKRNPGLLNSTRRDASMVIAEGMGVAIVAHNIPPGMSD 321 +I L +TY SS MPQK+NP + R V + MG+ + +P ++ Sbjct: 264 FKFIELD----DTYATGSSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLP--LAY 317 Query: 322 AKDVKPNKEMVLNTVKV----LKNWESILGALVIDPKRALEELNSDWTASQELADVLMRK 377 KD++ +KE + +TVK L+ + ++ + ++ + D++ + ELAD L +K Sbjct: 318 NKDLQEDKEGMFDTVKTVEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKK 377 Query: 378 YKLPFRVGHHFASEVVEYAKANNIRPLEFPYDQAQRIYHEAVLNSEFPQALPLSEQEFRS 437 +PFR H ++V I + P+ EF QA L E++ + Sbjct: 378 -GMPFREAHEVVGKLVYTCIERGIYLSDMPF-------------GEFQQASTLFEEDIYT 423 Query: 438 TLDPVAIVRNRATVGGPQPAEMDRMLREATARVA 471 LDP V R + GG ++++ L +A A VA Sbjct: 424 VLDPYYAVEKRMSAGGTGFKQVEQALEKAKACVA 457 >MJ0791 [E] COG0165 Argininosuccinate lyase Mja Methanococcus jannaschii Length = 484 Score = 167 bits (423), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 121/450 (26%), Positives = 225/450 (50%), Gaps = 24/450 (5%) Query: 42 ATAVINTEEGLLDKSMTPLVVKGIRKVLADGELPGAKRPTL---VITFEPLLIQAAGPQI 98 A ++ E+G++ K +++G++++ G P+L + E LI+ G + Sbjct: 40 AHVIMLYEQGIIKKEDAKKIIEGLKEIYKKGMENLNLDPSLDDIHMVIESELIKKLGEDV 99 Query: 99 T-LLHAGRSSQDMLAT-LRAAILREDLLTLANQLNATTAALVRLAASQRDTIVPNYTNGV 156 +H GRS D +AT LR A LRE +L +A L ++ LA ++T++ YT+ Sbjct: 100 AGRMHTGRSRNDEVATDLRIA-LREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQ 158 Query: 157 AAQPNSYGHYLLGFAAALDRDAQRLREAYGRLDRSAMGTTVLNGTSWPLNRQRMADYLGF 216 AQP ++ H+LL + +A++RD RL +AY R++ S +G + T + +NR+R + LGF Sbjct: 159 HAQPVTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGF 218 Query: 217 AAIVDNAYDAAQLSAVDGPVEAGAVVSSIALHAGAFIQDVMTQYAQPRPWILLQEGGANT 276 A+++N+ D +SA D +E A ++ + + ++++ I + +T Sbjct: 219 DALIENSMDG--VSARDFILETMADLAILGTNLSKICEELILFSTYEFGTIEIANEFCST 276 Query: 277 YVSSAMPQKRNPGLLNSTRRDASMVIAEGMGVAIVAHNIPPGMS-DAKDVKPNK-EMVLN 334 SS MPQK+NP + R S + + + +P + D +++ P+ + V Sbjct: 277 --SSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRDLQEISPHLWDSVYT 334 Query: 335 TVKVLKNWESILGALVIDPKRALEELNSDWTASQELADVLMRKYKLPFRVGHHFASEVVE 394 T+ +K +L + I+ +R E ++++ + ELAD L+R+ +PFR H EVV Sbjct: 335 TIDTIKMVHGMLKTIKINKERMEELAKANYSTATELADTLVRETGIPFRTAHGIVGEVVR 394 Query: 395 YAKANNIRPLEFPYDQAQRIYHEAVLNSEFPQALPLSEQEFRSTLDPVAIVRNRATVGGP 454 R +E D + IY VL L + E++ + LDP V+ R +GGP Sbjct: 395 -------RSIEEKKDMIEVIYE--VLEK---YNLKVDEEKIKKALDPYENVKMRDVIGGP 442 Query: 455 QPAEMDRMLREATARVAQQDAWIKARQQRI 484 P E+++ ++ R+ + + + + Q+I Sbjct: 443 APEEVEKRIKVFRERLDRYEKEVDEKLQKI 472 >lin2196 [E] COG0165 Argininosuccinate lyase Lin Listeria innocua Length = 456 Score = 151 bits (382), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 110/397 (27%), Positives = 191/397 (48%), Gaps = 25/397 (6%) Query: 62 VKGIRKVLADGELPGAK-RPTLVITFEPLLIQAAGPQITLLHAGRSSQDMLATLRAAILR 120 +K +++ LA GEL + + + E LL + GP LH RS D +AT L+ Sbjct: 63 LKILQEKLALGELEFSTVNEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLK 122 Query: 121 EDLLTLANQLNATTAALVRLAASQRDTIVPNYTNGVAAQPNSYGHYLLGFAAALDRDAQR 180 E + + L A LV+ A + +TI+P YT+ AQP S+ H+LL + RD +R Sbjct: 123 EAVAEIIQSLKHLRAVLVQKAEANVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDLER 182 Query: 181 LREAYGRLDRSAMGTTVLNGTSWPLNRQRMADYLGFAAIVDNAYDAAQLSAVDGPVEAGA 240 L E+ R+D S +G+ L GT++P++R A+ LGF+A+ +N+ D +S D +E + Sbjct: 183 LEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAVYENSLDG--VSDRDFIIEFLS 240 Query: 241 VVSSIALHAGAFIQDVMTQYAQPRPWILLQEGGANTYVSSAMPQKRNPGLLNSTRRDASM 300 S + +H F ++++ + ++ L + A + SS MPQK+NP + R Sbjct: 241 NSSILMMHLSRFCEELILWTSHEFQFVELTD--AFSTGSSIMPQKKNPDMAELIRGKTGR 298 Query: 301 VIAEGMGVAIVAHNIPPGMSDAKDVKPNKEMVLNTVKVLKNWESILGALV----IDPKRA 356 V G+ V +P ++ KD++ +KE + +T++ + I ++ ++ Sbjct: 299 VYGNLFGMLTVLKGLP--LAYNKDLQEDKEGMFDTLETVHTSLDIFAGMIETMKVNADIM 356 Query: 357 LEELNSDWTASQELADVLMRKYKLPFRVGHHFASEVVEYAKANNIRPLEFPYDQAQRIYH 416 E D++ + ELAD L +K +PFR H ++V N I + + Q I+ Sbjct: 357 EESTQKDFSNATELADYLAKK-GVPFREAHEIVGKLVLECTQNGIYLQDVAFSHYQEIH- 414 Query: 417 EAVLNSEFPQALPLSEQEFRSTLDPVAIVRNRATVGG 453 PL E++ + L V+ R + GG Sbjct: 415 ------------PLIEEDIYTVLASKTAVQKRNSYGG 439 >MA1318 [E] COG0165 Argininosuccinate lyase Mac Methanosarcina acetivorans str.C2A Length = 491 Score = 149 bits (376), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 120/462 (25%), Positives = 220/462 (47%), Gaps = 24/462 (5%) Query: 39 INKATAVINTEEGLLDKSMTPLVVKGIRKVLADG-ELPGAKRPTLVITFEPLLIQAAGPQ 97 ++ A V+ E+G++ ++ G+ K+ +G E + I+ E LI G Sbjct: 38 VDLAHTVMLKEQGIISAEDCSKILAGLLKIREEGMEKLDFSYEDIHISLESRLIDMVGED 97 Query: 98 IT-LLHAGRSSQDMLATLRAAILREDLLTLANQLNATTAALVRLAASQRDTIVPNYTNGV 156 + +H+GRS D +AT LRE+LL L ++ A LV LA +T++P +T+ Sbjct: 98 VGGRMHSGRSRNDEVATCIRLTLREELLGLLEEIFALRKTLVSLAEKHTETLMPGFTHLQ 157 Query: 157 AAQPNSYGHYLLGFAAALDRDAQRLREAYGRLDRSAMGTTVLNGTSWPLNRQRMADYLGF 216 AQP + H+L AAL RD R+++A+ R++ +G T + LNR+R + LGF Sbjct: 158 HAQPTTLAHHLCAHEAALGRDFDRVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGF 217 Query: 217 AAIVDNAYDAAQLSAVDGPVEAGAVVSSIALHAGAFIQDVMTQYAQPRPWILLQEGGANT 276 +++N+ DA +S+ D +E +V S++ ++ ++++ + +I L + A+T Sbjct: 218 EGLLENSMDA--VSSRDFLIECASVFSNLMINLSRMAEELVIWSSSEFNFIELDDTYAST 275 Query: 277 YVSSAMPQKRNPGLLNSTRRDASMVIAEGMGVAIVAHNIPPGMS-DAKDVKPNKEMVLNT 335 SS MPQK+NP R + + M + + +P + D ++ PN + T Sbjct: 276 --SSIMPQKKNPDTAELMRGKTGVAVGALMSLLTICKGLPLSYNRDLQEATPNIWRSVET 333 Query: 336 VKV-LKNWESILGALVIDPKRALEELNSDWTASQELADVLMRKYKLPFRVGHHFASEVVE 394 V+ ++ E ++ + I P+ + + +T + ELAD +R+ +PFR H + Sbjct: 334 VRASVRVMEGMVRTMKIHPEVLSAQSVTGFTTATELADTFVREAGIPFRTAHQIVGMLAR 393 Query: 395 YAKANNIRPLEFPYDQAQRIYHEAVLNSEFPQALPLSEQEFRSTLDPVAIVRNRATVGGP 454 + I + D I L+S L+E+ + L+PV+ ++ R GGP Sbjct: 394 EGEKPTIEKI----DSVAEIVLGESLSSR-----GLTEKMIKEALNPVSNIKRRKIEGGP 444 Query: 455 QPAEMDRMLREATARVAQQDAWIKARQQRIAGSLQKLDADFD 496 P EM + +Q ++ +Q IA +D+ F+ Sbjct: 445 APEEMQHY-------IGRQQTELELNEQEIATIKDSIDSAFE 479 >BH3186 [E] COG0165 Argininosuccinate lyase Bha Bacillus halodurans Length = 458 Score = 148 bits (373), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 108/392 (27%), Positives = 184/392 (46%), Gaps = 24/392 (6%) Query: 84 ITFEPLLIQAAGPQITLLHAGRSSQDMLATLRAAILREDLLTLANQLNATTAALVRLAAS 143 + E LLI GP LH GRS D +AT LR+ + + AALV A Sbjct: 86 LNIEKLLIDEIGPVGGKLHTGRSRNDQVATDMHLYLRKQTKEILQLVKNVQAALVEQAKQ 145 Query: 144 QRDTIVPNYTNGVAAQPNSYGHYLLGFAAALDRDAQRLREAYGRLDRSAMGTTVLNGTSW 203 +T++P YT+ AQP S+ H+LL + L+RD R ++ RL+ S +G L GT++ Sbjct: 146 HVETLIPGYTHLQRAQPISFAHHLLAYFWMLERDYGRYEDSLKRLNVSPLGAGALAGTTF 205 Query: 204 PLNRQRMADYLGFAAIVDNAYDAAQLSAVDGPVEAGAVVSSIALHAGAFIQDVMTQYAQP 263 P++R+ A+ LGF I +N+ DA +S D VE + S + H ++++ +Q Sbjct: 206 PIDREYTAELLGFDGIYENSLDA--VSDRDFIVEFLSASSLLMTHLSRLCEELILWSSQE 263 Query: 264 RPWILLQEGGANTYVSSAMPQKRNPGLLNSTRRDASMVIAEGMGVAIVAHNIPPGMSDAK 323 ++ + + A SS MPQK+NP + R V + V +P ++ K Sbjct: 264 FQFVEMDDAFATG--SSIMPQKKNPDMAELIRGKTGRVYGSLFSLLTVLKGLP--LAYNK 319 Query: 324 DVKPNKEMVLNTVKVLKNWESILGALV----IDPKRALEELNSDWTASQELADVLMRKYK 379 D++ +KE + + VK +K +I ++ + + + ++ D++ + ELAD L K Sbjct: 320 DMQEDKEGMFDAVKTVKGSLAIFAGMIQTMKVKEETMTKAVHQDFSNATELADYLATK-G 378 Query: 380 LPFRVGHHFASEVVEYAKANNIRPLEFPYDQAQRIYHEAVLNSEFPQALPLSEQEFRSTL 439 +PFR H ++V I L+ P S++ A L +++ L Sbjct: 379 MPFREAHEVVGKLVLLCIQKGIYLLDLPL-------------SDYKAASDLFDEDIYDVL 425 Query: 440 DPVAIVRNRATVGGPQPAEMDRMLREATARVA 471 P +V R + GG E+ + + +A +A Sbjct: 426 QPKTVVARRTSAGGTGFTEVKKAIAKAEKILA 457