BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0007.p (262 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2515 [IQR] COG1028 Dehydrogenases with different specificities... 278 1e-74 Cgl2355 [IQR] COG1028 Dehydrogenases with different specificitie... 249 6e-66 AGc3482 [IQR] COG1028 Dehydrogenases with different specificitie... 112 1e-24 mll6858 [IQR] COG1028 Dehydrogenases with different specificitie... 107 2e-23 CAC2607 [IQR] COG1028 Dehydrogenases with different specificitie... 107 3e-23 >PA2515 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 253 Score = 278 bits (710), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 139/254 (54%), Positives = 177/254 (69%), Gaps = 4/254 (1%) Query: 9 RFAGKVAVVTGAAQGILRGVALGIAAEGGQVLMVDRAGFIHEVAMEAPEGRATGFVADLE 68 RF KVA+V+GAAQGI GVA + EG +V+ VDR+ +HE+A +A ADLE Sbjct: 4 RFRDKVALVSGAAQGIGLGVARRLLEEGARVVAVDRSELVHELAGDA----CLCLTADLE 59 Query: 69 THDGAQAAMARAIELHGRIDLLVNGVGGAIRMRPFAEFEADQIDAEIRRSLMPTLYGCHA 128 + Q + R +E GR+D+LVN VGG + +P+ + D+I+AE+RRSL+PTL+ C A Sbjct: 60 RYAECQRVLERTLERFGRLDILVNNVGGTLWAKPYQHYAEDEIEAELRRSLLPTLWCCRA 119 Query: 129 VLPHMLRAGRGTIVNVSSNATRGIRRVPYSAAKGGVNAMTMALAMEYGEQGIRVVATAPG 188 LP ML G G IVNVSS ATRG+ RVPY AAKGGVNA+T LA E +QGIRV A APG Sbjct: 120 ALPAMLGQGSGAIVNVSSVATRGVNRVPYGAAKGGVNALTACLAFETADQGIRVNAVAPG 179 Query: 189 GTKAPPRRVPRNVEGDSAQEQAWMQEAVQQVTGSTFFKRYATLEEQIAPILFMASDEASY 248 GT APPRR+PRN S +E+ W ++ V+Q S+ KRY +++EQ+A ILF+ASDEASY Sbjct: 180 GTDAPPRRIPRNAAAQSEEERRWYRQIVEQTLDSSLMKRYGSIDEQVAAILFLASDEASY 239 Query: 249 ITGAVLPVAGGDNG 262 ITG LPVAGGD G Sbjct: 240 ITGVTLPVAGGDLG 253 >Cgl2355 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cgl Corynebacterium glutamicum Length = 276 Score = 249 bits (635), Expect = 6e-66, Method: Compositional matrix adjust. Identities = 135/257 (52%), Positives = 170/257 (66%), Gaps = 3/257 (1%) Query: 9 RFAGKVAVVTGAAQGILRGVALGIAAEGGQVLMVDRAGFIHEVAME---APEGRATGFVA 65 RF G+ VVTGAAQGI VA IA E G +++VDR+ +HEVA E A G F+A Sbjct: 20 RFFGQGVVVTGAAQGIGMAVAHRIAYEDGNLVLVDRSPLVHEVAEELRKAGAGTVDSFIA 79 Query: 66 DLETHDGAQAAMARAIELHGRIDLLVNGVGGAIRMRPFAEFEADQIDAEIRRSLMPTLYG 125 DLET +GA A+ A + +D+++N VGG I +P+ E+ ++I EI RSL PTL+ Sbjct: 80 DLETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEYSEEEIRKEINRSLFPTLWM 139 Query: 126 CHAVLPHMLRAGRGTIVNVSSNATRGIRRVPYSAAKGGVNAMTMALAMEYGEQGIRVVAT 185 C A LP ++ G GTIVNVSS AT GI RVPY+AAKGGVN + A+A E +RVVAT Sbjct: 140 CRAALPILIGNGGGTIVNVSSIATGGINRVPYAAAKGGVNGIVSAMAREAAPHNVRVVAT 199 Query: 186 APGGTKAPPRRVPRNVEGDSAQEQAWMQEAVQQVTGSTFFKRYATLEEQIAPILFMASDE 245 APGGT AP R V R + E+ W Q+ V Q S+ KRY TLEEQ+API F+AS+E Sbjct: 200 APGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMKRYGTLEEQVAPICFLASEE 259 Query: 246 ASYITGAVLPVAGGDNG 262 ASYITG+V+PV GGD G Sbjct: 260 ASYITGSVMPVGGGDQG 276 >AGc3482 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 262 Score = 112 bits (279), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 85/258 (32%), Positives = 124/258 (48%), Gaps = 21/258 (8%) Query: 10 FAGKVAVVTGAAQGILRGVALGIAAEGGQVLMVDR---AGFIHEVAMEAPEGRAT-GFVA 65 +G+VA+VTGA GI + +A+G+A G V ++DR G A GR + A Sbjct: 14 LSGQVALVTGAGSGIGQRIAMGLAQSGANVALLDRRTDDGLAQTADFIARAGRKSIQIAA 73 Query: 66 DLETHDGAQAAMARAIELHGRIDLLVNGVGGAIRMRPFAEFEADQIDAEIRRSLMPTLYG 125 D+ + A+AR G + L VN G A P E E Q + +L Sbjct: 74 DVTSKQALTDAVARTQAELGALSLAVNAAGIA-NANPAEEMEESQFQTMMDINLKGVFLS 132 Query: 126 CHAVLPHMLRAGRGTIVNVSSNA----TRGIRRVPYSAAKGGVNAMTMALAMEYGEQGIR 181 C A ML+ GRG IVN++S + RG+ + Y+A+K GV M+ ++AME+ +GIR Sbjct: 133 CQAEANAMLKNGRGAIVNIASMSGVIVNRGLMQCHYNASKAGVIHMSKSMAMEWVGRGIR 192 Query: 182 VVATAPGGTKAPPRRVPRNVEGDSAQEQAWMQEAVQQVTGSTFFKRYATLEEQIAPILFM 241 V +PG T P P V E+ T +R A ++E + P +F+ Sbjct: 193 VNTISPGYTATPMNTRPEMVHQTKLFEE------------QTPMQRMAGVDEMVGPAIFL 240 Query: 242 ASDEASYITGAVLPVAGG 259 SD AS++TG L V GG Sbjct: 241 LSDAASFVTGVDLLVDGG 258 >mll6858 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 287 Score = 107 bits (268), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 90/258 (34%), Positives = 123/258 (47%), Gaps = 21/258 (8%) Query: 9 RFAGKVAVVTGAAQGILRGVALGIAAEGGQVLMV----DRAGFIHEVAMEAPEGRATGFV 64 + KVA++TG GI R VA+ A EG + +V DR + A+EA EGR V Sbjct: 43 KLEDKVALITGGDSGIGRSVAVLFAREGADIAIVYLAEDRDAKATKSAVEA-EGRRCILV 101 Query: 65 -ADLETHDGAQAAMARAIELHGRIDLLVNGVGGAIRMRPFAEFEADQIDAEIRRSLMPTL 123 AD+ D + A+A+ ++ GRID+LVN I FAE + D ++ +L Sbjct: 102 KADVSERDQCRNAVAQTVKAFGRIDVLVNNAAFQIHSSEFAELTEEHFDTTLKTNLYGYF 161 Query: 124 YGCHAVLPHMLRAGRGTIVNVSSNATRGIR-RVPYSAAKGGVNAMTMALAMEYGEQGIRV 182 + +PHM + G I S G + V YS KGG++A T AL+ +GIRV Sbjct: 162 HMAQEAVPHM-KPGSAIINTGSVTGIDGSKALVDYSMTKGGIHAFTRALSGNLLGKGIRV 220 Query: 183 VATAPGGTKAPPRRVPRNVEGDSAQEQAWMQEAVQQVTGSTFFKRYATLEEQIAPILFMA 242 A APG P P N A + V + T KR A EE +F+A Sbjct: 221 NAVAPG-----PVWTPLNPSDKEAGD-------VSKFGADTPMKRPAQPEELAPAYVFLA 268 Query: 243 SDE-ASYITGAVLPVAGG 259 S +SYITG +LPV GG Sbjct: 269 SPHCSSYITGEILPVVGG 286 >CAC2607 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 267 Score = 107 bits (267), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 78/260 (30%), Positives = 123/260 (47%), Gaps = 11/260 (4%) Query: 5 LPRARFAGKVAVVTGAAQGILRGVALGIAAEGGQVLMVDRAGFIHEVAMEAPEG---RAT 61 L GK+A+VTGA+ GI +A A G ++ D + + ++A E +A Sbjct: 4 LKDFSLEGKIALVTGASYGIGFAIARSYANAGATIVFNDINQDLVDKGLKAYEAEGIKAH 63 Query: 62 GFVADLETHDGAQAAMARAIELHGRIDLLVNGVGGAIRMRPFAEFEADQIDAEIRRSLMP 121 G+V D+ D + + + G ID+LVN G I+ P E +A+ I L Sbjct: 64 GYVCDVTDEDKVNGFVKKVEKEVGLIDILVNN-AGIIKRIPMLEMKAEDFRKVIDVDLNA 122 Query: 122 TLYGCHAVLPHMLRAGRGTIVNVSSNATRGIRRV--PYSAAKGGVNAMTMALAMEYGEQG 179 AV+P M++ G G I+N+ S + R Y+AAKGG+ +T +A EYGE Sbjct: 123 PFIVSKAVIPGMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEYGEHN 182 Query: 180 IRVVATAPGGTKAPPRRVPRNVEGDSAQEQAWMQEAVQQVTGSTFFKRYATLEEQIAPIL 239 I+ PG P R ++ D ++ Q + T R+ T E+ + P + Sbjct: 183 IQCNGIGPGYIATPQTAPLRELQADGSK-----HPFDQFIIAKTPAARWGTPEDLMGPAV 237 Query: 240 FMASDEASYITGAVLPVAGG 259 F+ASD ++++ G VL V GG Sbjct: 238 FLASDASNFVNGHVLYVDGG 257