BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0376.p (372 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1311 [L] COG0305 Replicative DNA helicase Rso Ralstonia solan... 545 e-155 NMB0885 [L] COG0305 Replicative DNA helicase Nme Neisseria menin... 424 e-118 NMA1105 [L] COG0305 Replicative DNA helicase NmA Neisseria menin... 421 e-117 PA4931 [L] COG0305 Replicative DNA helicase Pae Pseudomonas aeru... 345 1e-94 VC0371 [L] COG0305 Replicative DNA helicase Vch Vibrio cholerae 317 3e-86 >RSc1311 [L] COG0305 Replicative DNA helicase Rso Ralstonia solanacearum Length = 473 Score = 545 bits (1404), Expect = e-155, Method: Compositional matrix adjust. Identities = 255/306 (83%), Positives = 286/306 (93%) Query: 43 SDPQLDALRVPPHSIEAEQSVLGGLLLDNAAWDRIADFVSAEDFYRYDHRIIFEHIVKLI 102 +DPQL++L+VPPHSIEAEQSVLGGLLLDNAAWDRIADF++ DFYRYDHR+IF +I KLI Sbjct: 15 TDPQLESLKVPPHSIEAEQSVLGGLLLDNAAWDRIADFINEHDFYRYDHRLIFHNIGKLI 74 Query: 103 NSTKPADVITVYEAMSTSGKAEEVGGLVYLNALAQNTPSAANIRRYAEIVRDRGILRKLI 162 + KPADVITVYE + +GKAEEVGGL YLNALAQNTPSAANIRRYAEIVRDRG+LR+L+ Sbjct: 75 SQAKPADVITVYEQLQAAGKAEEVGGLAYLNALAQNTPSAANIRRYAEIVRDRGVLRQLV 134 Query: 163 TVADEISGNAFNPQGKDVKSMLDEAESKIFAIAEEGSRGSQGFMEIQPLLTQVVERIDEL 222 T+ADEIS AFNPQG+DV+ +LDEAESK+FAIAEEG+RG +GF+EIQPLLTQVVERIDEL Sbjct: 135 TIADEISAGAFNPQGRDVRQLLDEAESKVFAIAEEGARGQKGFLEIQPLLTQVVERIDEL 194 Query: 223 YNRDNTSDITGVPTGFMDLDKMTSGLQPGDLIIVAGRPSMGKTAFSINIGEHVAIESGLP 282 Y+RDN SDITGVPTGF+DLD+MTSG+Q GDLIIVAGRPSMGKTAFS+NIGEHVA+E GLP Sbjct: 195 YHRDNQSDITGVPTGFVDLDRMTSGMQGGDLIIVAGRPSMGKTAFSLNIGEHVAVEQGLP 254 Query: 283 VAVFSMEMGGAQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQFYIDETP 342 VAVFSMEM G QLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQ +IDETP Sbjct: 255 VAVFSMEMAGTQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQLFIDETP 314 Query: 343 ALSPIE 348 AL+P+E Sbjct: 315 ALNPME 320 >NMB0885 [L] COG0305 Replicative DNA helicase Nme Neisseria meningitidis MC58 Length = 468 Score = 424 bits (1090), Expect = e-118, Method: Compositional matrix adjust. Identities = 205/304 (67%), Positives = 245/304 (80%) Query: 42 SSDPQLDALRVPPHSIEAEQSVLGGLLLDNAAWDRIADFVSAEDFYRYDHRIIFEHIVKL 101 S D ++ AL +PPHS+EAEQSVLGGL+L+N AWDRIAD VS EDFYR++HR+IF I KL Sbjct: 9 SEDREVGALSLPPHSMEAEQSVLGGLMLENPAWDRIADVVSGEDFYRHEHRLIFRSIAKL 68 Query: 102 INSTKPADVITVYEAMSTSGKAEEVGGLVYLNALAQNTPSAANIRRYAEIVRDRGILRKL 161 IN ++PADVITV E + + + E GG YL LAQNTPSAANIRRYAEIVR+R I+R+L Sbjct: 69 INESRPADVITVQEDLQRNEELEAAGGFEYLITLAQNTPSAANIRRYAEIVRERSIMRQL 128 Query: 162 ITVADEISGNAFNPQGKDVKSMLDEAESKIFAIAEEGSRGSQGFMEIQPLLTQVVERIDE 221 V EI+ +A+NPQG+D +LDEAE+K+F IAE ++ QGF+E+ LL +VV+RID Sbjct: 129 AEVGTEIARSAYNPQGRDAGQLLDEAENKVFQIAESTAKSKQGFLEMPDLLKEVVQRIDM 188 Query: 222 LYNRDNTSDITGVPTGFMDLDKMTSGLQPGDLIIVAGRPSMGKTAFSINIGEHVAIESGL 281 LY+RDN ++TGVPTGF+DLDK TSGLQPGDLIIVAGRPSMGKTAFSINI EHVA+E L Sbjct: 189 LYSRDNPDEVTGVPTGFIDLDKKTSGLQPGDLIIVAGRPSMGKTAFSINIAEHVAVEGRL 248 Query: 282 PVAVFSMEMGGAQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQFYIDET 341 PVAVFSMEMGGAQL MRMLGSVGRLDQ L+TGRL DE W RL A+ K++DA YIDET Sbjct: 249 PVAVFSMEMGGAQLVMRMLGSVGRLDQSVLKTGRLEDEHWGRLNEAVVKLSDAPVYIDET 308 Query: 342 PALS 345 P L+ Sbjct: 309 PGLT 312 >NMA1105 [L] COG0305 Replicative DNA helicase NmA Neisseria meningitidis Z2491 Length = 468 Score = 421 bits (1083), Expect = e-117, Method: Compositional matrix adjust. Identities = 204/304 (67%), Positives = 244/304 (80%) Query: 42 SSDPQLDALRVPPHSIEAEQSVLGGLLLDNAAWDRIADFVSAEDFYRYDHRIIFEHIVKL 101 S D ++ AL +PPHS+EAEQSVLGGL+L+N AWDRIAD VS EDFYR++HR+IF I KL Sbjct: 9 SEDREVGALSLPPHSMEAEQSVLGGLMLENPAWDRIADVVSGEDFYRHEHRLIFRSIAKL 68 Query: 102 INSTKPADVITVYEAMSTSGKAEEVGGLVYLNALAQNTPSAANIRRYAEIVRDRGILRKL 161 IN ++PADVITV E + + + E GG YL LAQNTPSAANIRRYAEIVR+R I+R+L Sbjct: 69 INESRPADVITVQEDLQRNEELEAAGGFEYLITLAQNTPSAANIRRYAEIVRERSIMRQL 128 Query: 162 ITVADEISGNAFNPQGKDVKSMLDEAESKIFAIAEEGSRGSQGFMEIQPLLTQVVERIDE 221 V EI+ +A+NPQG+D +LDEAE+K+F IAE ++ QGF+E+ LL +VV+RID Sbjct: 129 AEVGTEIARSAYNPQGRDAGQLLDEAENKVFQIAESTAKSKQGFLEMPDLLKEVVQRIDM 188 Query: 222 LYNRDNTSDITGVPTGFMDLDKMTSGLQPGDLIIVAGRPSMGKTAFSINIGEHVAIESGL 281 LY+RDN ++TGV TGF+DLDK TSGLQPGDLIIVAGRPSMGKTAFSINI EHVA+E L Sbjct: 189 LYSRDNPDEVTGVSTGFIDLDKKTSGLQPGDLIIVAGRPSMGKTAFSINIAEHVAVEGKL 248 Query: 282 PVAVFSMEMGGAQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQFYIDET 341 PVAVFSMEMGGAQL MRMLGSVGRLDQ L+TGRL DE W RL A+ K++DA YIDET Sbjct: 249 PVAVFSMEMGGAQLVMRMLGSVGRLDQSVLKTGRLEDEHWGRLNEAVVKLSDAPVYIDET 308 Query: 342 PALS 345 P L+ Sbjct: 309 PGLT 312 >PA4931 [L] COG0305 Replicative DNA helicase Pae Pseudomonas aeruginosa Length = 464 Score = 345 bits (884), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 166/315 (52%), Positives = 230/315 (73%), Gaps = 3/315 (0%) Query: 41 ESSDPQLDALRVPPHSIEAEQSVLGGLLLDNAAWDRIADFVSAEDFYRYDHRIIFEHIVK 100 E D + AL+VPPHSIEAEQ+VLGGL+LDN AW+R++D VS DFYR+DHR+IF I K Sbjct: 8 EQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRLIFRAIYK 67 Query: 101 LINSTKPADVITVYEAMSTSGKAEEVGGLVYLNALAQNTPSAANIRRYAEIVRDRGILRK 160 L + +P DV+T+ E + G+ +VGGL YL LA+N PS ANI+ YA+I+R+R LR+ Sbjct: 68 LAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIRERATLRQ 127 Query: 161 LITVADEISGNAFNPQGKDVKSMLDEAESKIFAIAEEGSRGSQGFMEIQPLLTQVVERID 220 LI +++EI+ +AF+P+G+ +LDEAE KIF +AE + + G + I +L + ++RID Sbjct: 128 LIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPK-TGGPVGISDILVKTIDRID 186 Query: 221 ELYNRDNTSDITGVPTGFMDLDKMTSGLQPGDLIIVAGRPSMGKTAFSINIGEHVAIESG 280 L+N T +TGV TGF DLD+ TSGLQP DLIIVAGRPSMGKT F++N+ E+ + + Sbjct: 187 YLFN--TTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAVMRTD 244 Query: 281 LPVAVFSMEMGGAQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQKMNDAQFYIDE 340 V V+S+EM + MRML S+GR+DQ ++R+G+L DEDWPRLT AI +ND + +ID+ Sbjct: 245 KAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKLFIDD 304 Query: 341 TPALSPIELRARSRR 355 T +SP E+RAR+RR Sbjct: 305 TAGISPSEMRARTRR 319 >VC0371 [L] COG0305 Replicative DNA helicase Vch Vibrio cholerae Length = 468 Score = 317 bits (812), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 156/326 (47%), Positives = 225/326 (69%), Gaps = 2/326 (0%) Query: 31 GNPEFFRGQRESSDPQLDALRVPPHSIEAEQSVLGGLLLDNAAWDRIADFVSAEDFYRYD 90 +P R+ D Q+DA++VPPHS+EAEQSV+GGLLLDN WD +++ V +DFY Sbjct: 2 ADPRTDNRNRKIPDAQVDAIKVPPHSLEAEQSVIGGLLLDNERWDTVSEHVMTQDFYSRP 61 Query: 91 HRIIFEHIVKLINSTKPADVITVYEAMSTSGKAEEVGGLVYLNALAQNTPSAANIRRYAE 150 HR+IF+ + ++ + KP D+IT+ E + + E+VGG YL LA+NTPSAANI YAE Sbjct: 62 HRLIFDGVKSILEAGKPLDLITLSEYLEQREQLEDVGGFAYLADLAKNTPSAANINAYAE 121 Query: 151 IVRDRGILRKLITVADEISGNAFNPQGKDVKSMLDEAESKIFAIAEEGSRGSQGFMEIQP 210 IV +R ++R LI VA+EI+ ++PQG++ + +LD AESK+FAIAE + ++G + Sbjct: 122 IVAERALVRNLIGVANEIADAGYDPQGRNAEDLLDLAESKVFAIAEARTSENEGPKNVDS 181 Query: 211 LLTQVVERIDELYNRDNTSDITGVPTGFMDLDKMTSGLQPGDLIIVAGRPSMGKTAFSIN 270 +L + +ERI+ LY + +TGV TGF DL+K T+GLQ DLIIVA RPSMGKT F++N Sbjct: 182 ILERTLERIELLY-KTPQDGVTGVNTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMN 240 Query: 271 IGEHVAIESGLPVAVFSMEMGGAQLAMRMLGSVGRLDQHRLRTGRLLDEDWPRLTHAIQ- 329 + E+ A+E PV +FS+EM Q+ MRML S+ R+DQ ++RTG+L DEDW R++ + Sbjct: 241 LCENAAMEQDKPVLIFSLEMPAEQIMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGI 300 Query: 330 KMNDAQFYIDETPALSPIELRARSRR 355 M YID++ L+P E+R+R+RR Sbjct: 301 LMEKKNMYIDDSSGLTPTEVRSRARR 326