BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0319.p (507 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2153 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 592 e-169 NMB1659 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 484 e-136 NMA1917 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 482 e-135 PA5338 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolase... 478 e-134 VC2710 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolase... 476 e-134 >RSc2153 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Rso Ralstonia solanacearum Length = 735 Score = 592 bits (1527), Expect = e-169, Method: Compositional matrix adjust. Identities = 285/404 (70%), Positives = 337/404 (83%), Gaps = 1/404 (0%) Query: 1 VATFAHLIPKLEEYLTPSELKKVKEAYRFADEMHLGQMRKSGEPYISHPLAVAEICAEWK 60 V + A L KL YL P+++K VKEA+ F+DE HLGQ R+SGEPYI+HP+AVAEICA WK Sbjct: 16 VVSIAGLTEKLS-YLKPADIKLVKEAFHFSDEAHLGQYRQSGEPYITHPVAVAEICAGWK 74 Query: 61 LDAQAMMAAFLHDVMEDQGVKKEELIERFGASVASLVDGLSKLDKIEFQSQVEAQAENFR 120 LD Q++MAA LHDV+EDQGV K EL E+FG VA LVDGL+KLDK+EFQS+ +AQAE+FR Sbjct: 75 LDVQSIMAALLHDVIEDQGVTKSELAEKFGPKVAELVDGLTKLDKLEFQSREQAQAESFR 134 Query: 121 KMLLAMARDVRVILVKLADRLHNMRTLGSMPPEKKRRISRETMEVYVPIAHRLGLNNIYR 180 KMLLAMARDVRVILVKLADR HNMRTL +PPEK+RRI+ ETME+Y PIAHRLGLN YR Sbjct: 135 KMLLAMARDVRVILVKLADRTHNMRTLDHVPPEKRRRIAGETMEIYAPIAHRLGLNTTYR 194 Query: 181 ELQELSFAHLHPLRHRTLLKAVKAARGNRREVVTKIMESVTSTLIAAGIPAQVDGREKTL 240 ELQELSF P R+ TL KAVKAARGNRREVV++I+E+ L AG+ A++ GREKTL Sbjct: 195 ELQELSFRIGSPFRYATLEKAVKAARGNRREVVSRILEAAQRALGDAGVSAELTGREKTL 254 Query: 241 YGIYRKMRNKHLSFSQVLDVYGFRVVVDSFANCYVALGTLHSLFKPMPGKFKDYIAIPKL 300 Y IYRKM +K LSFSQVLDVYGFRVVV++ +CY+A+G LH L+KPMPGKFKDYIAIPK+ Sbjct: 255 YSIYRKMHDKQLSFSQVLDVYGFRVVVETQMHCYMAVGALHGLYKPMPGKFKDYIAIPKI 314 Query: 301 NGYQSLHTTLIGPYGTPVEFQIRTTDMHRVAESGVAAHWLYKDDEGSLTDLQQRTHAWLQ 360 NGYQS+HTTL+GP+GTPVEFQIRT +M+++AE+GVAAHW+YK QQ+ H WLQ Sbjct: 315 NGYQSVHTTLVGPFGTPVEFQIRTREMNQIAEAGVAAHWMYKQHHDEPDRAQQQAHQWLQ 374 Query: 361 SLLDIQKQTGDSAEFLEHVKVDLFPDSVYVFTPKSKIIALPRGA 404 SLLDIQ Q+GDS EFLEHVK+DLFPD+VYVFTPK +I ALPRGA Sbjct: 375 SLLDIQSQSGDSQEFLEHVKIDLFPDAVYVFTPKGEIRALPRGA 418 >NMB1659 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Nme Neisseria meningitidis MC58 Length = 718 Score = 484 bits (1245), Expect = e-136, Method: Compositional matrix adjust. Identities = 221/391 (56%), Positives = 297/391 (75%) Query: 14 YLTPSELKKVKEAYRFADEMHLGQMRKSGEPYISHPLAVAEICAEWKLDAQAMMAAFLHD 73 YL P E ++++A +A H GQ RKSGEPYI+HP+AVA A W +D Q + A +HD Sbjct: 27 YLKPEEQAELEKAVAYAFRAHDGQTRKSGEPYITHPIAVATQLALWHMDIQGLCAGVMHD 86 Query: 74 VMEDQGVKKEELIERFGASVASLVDGLSKLDKIEFQSQVEAQAENFRKMLLAMARDVRVI 133 V+ED GV K E+ FG ++A +VDGLSKL+K++F+ E QAE+FRK++LAM +DVRVI Sbjct: 87 VLEDTGVTKGEMAAVFGNTIAEMVDGLSKLEKLKFEDHAEHQAESFRKLILAMTKDVRVI 146 Query: 134 LVKLADRLHNMRTLGSMPPEKKRRISRETMEVYVPIAHRLGLNNIYRELQELSFAHLHPL 193 +VKLADRLHNMRTLGSM P+K+RRI+RET+E+Y IA+R+GLNN Y+ELQ+LSF +LHP Sbjct: 147 VVKLADRLHNMRTLGSMRPDKRRRIARETLEIYAQIANRIGLNNAYQELQDLSFQNLHPN 206 Query: 194 RHRTLLKAVKAARGNRREVVTKIMESVTSTLIAAGIPAQVDGREKTLYGIYRKMRNKHLS 253 R+ TL KA+ +R NR++VV K++ + L+ A I A++ GREK LYGI++KM K L Sbjct: 207 RYETLKKAMDKSRKNRQDVVGKVLRAFGQRLVGANIEAKIKGREKNLYGIHQKMMAKKLR 266 Query: 254 FSQVLDVYGFRVVVDSFANCYVALGTLHSLFKPMPGKFKDYIAIPKLNGYQSLHTTLIGP 313 F++V+D+YGFRV+V+S CY ALG LH+L++P PG+FKDYIAIPK NGYQSLHTTL+GP Sbjct: 267 FAEVMDIYGFRVIVNSIPACYAALGALHTLYQPKPGRFKDYIAIPKSNGYQSLHTTLVGP 326 Query: 314 YGTPVEFQIRTTDMHRVAESGVAAHWLYKDDEGSLTDLQQRTHAWLQSLLDIQKQTGDSA 373 YG P+E QIRT +M VAE G+A HW YK ++ T+ WL+++LD+Q + ++ Sbjct: 327 YGLPIEVQIRTKEMDAVAEGGIAGHWSYKSYSKTVDQAVLHTNRWLKNILDLQASSANAI 386 Query: 374 EFLEHVKVDLFPDSVYVFTPKSKIIALPRGA 404 EFLEHVKVDLFP+ +Y+ TPK KI+ LP+GA Sbjct: 387 EFLEHVKVDLFPNEIYILTPKGKILTLPKGA 417 >NMA1917 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases NmA Neisseria meningitidis Z2491 Length = 725 Score = 482 bits (1240), Expect = e-135, Method: Compositional matrix adjust. Identities = 221/398 (55%), Positives = 299/398 (75%) Query: 7 LIPKLEEYLTPSELKKVKEAYRFADEMHLGQMRKSGEPYISHPLAVAEICAEWKLDAQAM 66 L+ + YL P E ++++A +A H GQ RKSGEPYI+HP+AVA A W +D Q + Sbjct: 27 LLFRTASYLKPEEQVELEKAVAYAFHAHDGQTRKSGEPYITHPIAVATQLALWHMDIQGL 86 Query: 67 MAAFLHDVMEDQGVKKEELIERFGASVASLVDGLSKLDKIEFQSQVEAQAENFRKMLLAM 126 A +HDV+ED GV K E+ FG ++A +VDGLSKL+K++F+ E QAE+FRK++LAM Sbjct: 87 CAGVMHDVLEDTGVTKGEMAAVFGNTIAEMVDGLSKLEKLKFEDHAEHQAESFRKLILAM 146 Query: 127 ARDVRVILVKLADRLHNMRTLGSMPPEKKRRISRETMEVYVPIAHRLGLNNIYRELQELS 186 +DVRVI+VKLADRLHNMRTLGSM P+K+RRI+RET+E+Y IA+R+GLNN Y+ELQ+LS Sbjct: 147 TKDVRVIVVKLADRLHNMRTLGSMRPDKRRRIARETLEIYAQIANRIGLNNAYQELQDLS 206 Query: 187 FAHLHPLRHRTLLKAVKAARGNRREVVTKIMESVTSTLIAAGIPAQVDGREKTLYGIYRK 246 F +LHP R+ TL KA+ +R NR++VV K++ + L+ I A++ GREK LYGI++K Sbjct: 207 FQNLHPNRYETLKKAMDKSRKNRQDVVGKVLRAFGQRLVGVNIEAKIKGREKNLYGIHQK 266 Query: 247 MRNKHLSFSQVLDVYGFRVVVDSFANCYVALGTLHSLFKPMPGKFKDYIAIPKLNGYQSL 306 M K L F++V+D+YGFRV+V+S CY ALG LH+L++P PG+FKDYIAIPK NGYQSL Sbjct: 267 MMAKKLRFAEVMDIYGFRVIVNSIPACYAALGALHTLYQPKPGRFKDYIAIPKSNGYQSL 326 Query: 307 HTTLIGPYGTPVEFQIRTTDMHRVAESGVAAHWLYKDDEGSLTDLQQRTHAWLQSLLDIQ 366 HTTL+GPYG P+E QIRT +M VAE G+A HW YK ++ T+ WL+++LD+Q Sbjct: 327 HTTLVGPYGLPIEVQIRTKEMDAVAEGGIAGHWSYKSYSKTVDQAVLHTNRWLKNILDLQ 386 Query: 367 KQTGDSAEFLEHVKVDLFPDSVYVFTPKSKIIALPRGA 404 + ++ EFLEHVKVDLFP+ +Y+ TPK KI+ LP+GA Sbjct: 387 ASSANAIEFLEHVKVDLFPNEIYILTPKGKILTLPKGA 424 >PA5338 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Pae Pseudomonas aeruginosa Length = 701 Score = 478 bits (1230), Expect = e-134, Method: Compositional matrix adjust. Identities = 216/395 (54%), Positives = 299/395 (75%) Query: 10 KLEEYLTPSELKKVKEAYRFADEMHLGQMRKSGEPYISHPLAVAEICAEWKLDAQAMMAA 69 +L YL P ++ V+ AY +A++ H GQ R+SGEPY++HPLAV+ I A+ +D Q++MAA Sbjct: 10 RLSSYLGPDQVNLVRRAYYYAEQAHDGQRRRSGEPYVTHPLAVSNILADMHMDHQSLMAA 69 Query: 70 FLHDVMEDQGVKKEELIERFGASVASLVDGLSKLDKIEFQSQVEAQAENFRKMLLAMARD 129 LHDV+ED G+ KE L +FG +V+ LVDG+SKL ++ F+++ EAQAENF+KM +AMARD Sbjct: 70 MLHDVIEDTGIAKEALTAQFGETVSELVDGVSKLTQMNFETKAEAQAENFQKMAMAMARD 129 Query: 130 VRVILVKLADRLHNMRTLGSMPPEKKRRISRETMEVYVPIAHRLGLNNIYRELQELSFAH 189 +RVILVKLADRLHNMRTL + EK+RRI++ET+E+Y PIA+RLG++ + E ++L F Sbjct: 130 IRVILVKLADRLHNMRTLEVLSGEKRRRIAKETLEIYAPIANRLGMHTMRVEFEDLGFKA 189 Query: 190 LHPLRHRTLLKAVKAARGNRREVVTKIMESVTSTLIAAGIPAQVDGREKTLYGIYRKMRN 249 +HP+R + +AVK ARGNRRE+V KI ES+ + L G+ QV GREK LY IY+KMR Sbjct: 190 MHPMRAERIRQAVKKARGNRREIVGKIQESLVNCLAREGMEGQVIGREKHLYSIYQKMRG 249 Query: 250 KHLSFSQVLDVYGFRVVVDSFANCYVALGTLHSLFKPMPGKFKDYIAIPKLNGYQSLHTT 309 K +F++++DVY FR++VD CY LG +HSL+KP PG+FKDYIAIPK NGYQSLHTT Sbjct: 250 KRKAFNEIMDVYAFRIIVDKVDTCYRVLGAVHSLYKPFPGRFKDYIAIPKANGYQSLHTT 309 Query: 310 LIGPYGTPVEFQIRTTDMHRVAESGVAAHWLYKDDEGSLTDLQQRTHAWLQSLLDIQKQT 369 L G +G P+E QIRT +M +A G+AAHWLYK ++ + R W++ +L++Q++ Sbjct: 310 LFGMHGVPIEIQIRTREMEEMANHGIAAHWLYKSNDETPKGTHARARQWVKGVLELQQRA 369 Query: 370 GDSAEFLEHVKVDLFPDSVYVFTPKSKIIALPRGA 404 G+S EF+E+VK+DLFPD VYVFTPK +I+ LP+G+ Sbjct: 370 GNSLEFIENVKIDLFPDEVYVFTPKGRIMELPKGS 404 >VC2710 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Vch Vibrio cholerae Length = 705 Score = 476 bits (1224), Expect = e-134, Method: Compositional matrix adjust. Identities = 224/402 (55%), Positives = 299/402 (74%), Gaps = 1/402 (0%) Query: 4 FAHLIPKLEEYLTPSELKKVKEAYRFADEMHLGQMRKSGEPYISHPLAVAEICAEWKLDA 63 F L +EYLT +++ ++++Y A + H GQ R SGEPYI HP+AVA I AE +LD Sbjct: 4 FDSLKDVAQEYLTEPQIEALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDL 63 Query: 64 QAMMAAFLHDVMEDQGVKKEELIERFGASVASLVDGLSKLDKIEFQSQVEAQAENFRKML 123 + + AA LHDV+ED V KE+L FG+SVA LVDG+SKLDK++F+ + EAQAENFRKM+ Sbjct: 64 ETLQAALLHDVIEDCDVTKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMV 123 Query: 124 LAMARDVRVILVKLADRLHNMRTLGSMPPEKKRRISRETMEVYVPIAHRLGLNNIYRELQ 183 LAM +D+RVIL+KLADR NMRTLG++ P+KKRRI+RET+E+Y P+AHRLG++NI EL+ Sbjct: 124 LAMVQDIRVILIKLADRTPNMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKTELE 183 Query: 184 ELSFAHLHPLRHRTLLKAVKAARGNRREVVTKIMESVTSTLIAAGIPAQVDGREKTLYGI 243 EL F L+P R+R L + VKAARGNR+E++ +I + L G+PA+V GREK L+ I Sbjct: 184 ELGFEALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSI 243 Query: 244 YRKMRNKHLSFSQVLDVYGFRVVVDSFANCYVALGTLHSLFKPMPGKFKDYIAIPKLNGY 303 Y KM+ K F ++D+Y FR+VVD+ CY LG +HSL+KP P + KDYIA+PK NGY Sbjct: 244 YNKMKTKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGY 303 Query: 304 QSLHTTLIGPYGTPVEFQIRTTDMHRVAESGVAAHWLYK-DDEGSLTDLQQRTHAWLQSL 362 QSLHT+++GP+G PVE QIRT DM ++A+ GVAAHW YK + E T Q + W+QSL Sbjct: 304 QSLHTSMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSL 363 Query: 363 LDIQKQTGDSAEFLEHVKVDLFPDSVYVFTPKSKIIALPRGA 404 L++Q+ G+S EF+E+VK DLFPD +YVFTPK +I+ LP GA Sbjct: 364 LELQQSAGNSFEFIENVKSDLFPDEIYVFTPKGRIVELPMGA 405