BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0197.p (1343 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1447 0.0 PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1183 0.0 VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1150 0.0 HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1130 0.0 NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1129 0.0 >RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Rso Ralstonia solanacearum Length = 1046 Score = 1447 bits (3745), Expect = 0.0, Method: Compositional matrix adjust. Identities = 723/1043 (69%), Positives = 823/1043 (78%), Gaps = 25/1043 (2%) Query: 3 ILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAGQAQALTREDEARLNGLLTY 62 PG+ ALSAFR QRLL+ L+ +D I VS +YLHFV A L+ +D AR+ LLTY Sbjct: 6 CFPGALALSAFRQQRLLSTLKRIDPEIDAVSAQYLHFVAADAP--LSADDAARVQALLTY 63 Query: 63 GDPFNGSDEGDAFVVIPRFGTISPWASKATDIVRNCGMGHIHRVERGIIFRVQVKTGLL- 121 G P + EGD FVVIPRFGTISPWASKAT+I R+C + IHR+ERG+ F V K GLL Sbjct: 64 GSPASAETEGDRFVVIPRFGTISPWASKATEIARHCALPQIHRIERGVEFTVTCKKGLLR 123 Query: 122 ---GGTKKLNEASIPAVAALLHDRMTETVLRDPQDAAGLFSELQAKPLESVDVIGG---- 174 GG K+L+EA+ AVAA LHDRMTE V+ + GLF L AK L VD+ G Sbjct: 124 GLTGGRKQLDEATRAAVAAHLHDRMTEIVVATREAGYGLFDVLPAKALRFVDLGSGDAAA 183 Query: 175 GRAALERANTELGLALSDDEIDYLVDAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADW 234 GR ALE ANTE+GLALSDDEIDYLVDA+ K RNPTDVELMMFAQANSEHCRHKIFNADW Sbjct: 184 GRGALEAANTEMGLALSDDEIDYLVDAYRKLGRNPTDVELMMFAQANSEHCRHKIFNADW 243 Query: 235 TIDGEKQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGATKGNV----Y 290 TIDGE QDKSLF MI+NTHQLAP+GTVVAYSDN++++EG R++ T G Y Sbjct: 244 TIDGETQDKSLFAMIRNTHQLAPQGTVVAYSDNAAVMEGGMAERWFPHAGTDGETGVPQY 303 Query: 291 EASDELTHILMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNL 350 + LTH LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRG+KPKAGLTGFTVSNL Sbjct: 304 GRREALTHTLMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGAKPKAGLTGFTVSNL 363 Query: 351 MVTHAVQPWENARDVAQPVDQRDE-HAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFG 409 ++ AVQ WENARD AQP QR+ G GKP+RIASPLQIMI+GP+GGAAFNNEFG Sbjct: 364 LLPEAVQSWENARDTAQPAAQRNPGDTAPGPVGKPDRIASPLQIMIEGPIGGAAFNNEFG 423 Query: 410 RPNLGGYFRTYEQNVGGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMR 469 RPNLGGYFR YEQNVGG V GYHKPIMIAGG+GNI A HT K+ LP G+LL+QLGGPGMR Sbjct: 424 RPNLGGYFRVYEQNVGGTVRGYHKPIMIAGGIGNIDAGHTHKHGLPAGTLLVQLGGPGMR 483 Query: 470 IGMGGGAASSMATGVNTADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGA 529 IGMGGGAASSMATG NTADLDFDSVQRGNPEM+RRAQEVINACWALG+DNPI SIHDVGA Sbjct: 484 IGMGGGAASSMATGTNTADLDFDSVQRGNPEMQRRAQEVINACWALGEDNPILSIHDVGA 543 Query: 530 GGLSNAFPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLDLFKY 589 GG+SNAFPE+ + A RGA FDLR+V LEESGL+P EIW NESQERY LAI P F+ Sbjct: 544 GGISNAFPELVDGADRGARFDLRQVHLEESGLSPAEIWCNESQERYTLAIAPGDFPRFQA 603 Query: 590 LCERERAPFAVVGTATEERQLKVIDPEH-----NNNPVDMPMDVLLGKPPKMHRDVQHVE 644 +CERERAPF+VVG ATEE+QL+V+D + + PV+MPMDVLLGKPP+MHRDV+ V Sbjct: 604 MCERERAPFSVVGFATEEQQLQVVDGDAPADAVEHFPVNMPMDVLLGKPPRMHRDVRRVA 663 Query: 645 KQLPPVDLTGMDLVDVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADV 704 + LP VD+TG+DL VA+ VLR P VA KSFLITIGDR+VG + RDQMVGPWQVPVADV Sbjct: 664 QALPEVDVTGLDLETVARDVLRHPTVASKSFLITIGDRTVGGLNTRDQMVGPWQVPVADV 723 Query: 705 AVTAMGLEGYLGEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANW 764 AVT + +GY GEAM MGERTPLAVIDAPASGRMA+GEAITNIAAAPIA + +KLSANW Sbjct: 724 AVTTLDYKGYAGEAMTMGERTPLAVIDAPASGRMAIGEAITNIAAAPIASLAQLKLSANW 783 Query: 765 MAACGQPGQDAALFDTVKAVGMELCPALGISIPVGKDSLSMRSTWSDEAGAKSVTSPVSL 824 MAACG G+DA L+DTVKAVGMELCPALGISIPVGKDSLSMR+ W D AK V +PVSL Sbjct: 784 MAACGVDGEDARLYDTVKAVGMELCPALGISIPVGKDSLSMRTKWDDAGEAKEVVAPVSL 843 Query: 825 IVSGFAPVTDVRRVLTPQLRK-----DKGETVLILIDLGRGKNRMGASALTQVMQQIGNE 879 IVS FAPVTDVR+ LTPQL+ + +T LI+IDLG GK+R+G S L QV QQIGN Sbjct: 844 IVSAFAPVTDVRKTLTPQLKPVASAGEAADTTLIVIDLGHGKHRLGGSILAQVTQQIGNS 903 Query: 880 TPDVDSAEDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILT 939 PDV AEDLK FF AIQQLN LLAYHDRSDGGL+AT+ EMAFAGH G+S+N+D+LT Sbjct: 904 VPDVGDAEDLKRFFAAIQQLNAAGMLLAYHDRSDGGLWATVCEMAFAGHCGVSINVDMLT 963 Query: 940 MEAEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLG 999 ++ HA+D+GD+KNW QV+ RR ++TLRALF+EELGAVIQVPA Q+ V VLR + L Sbjct: 964 LDGAHASDYGDAKNWAQQVSGRRADMTLRALFAEELGAVIQVPAAQRDAVFAVLREHGLA 1023 Query: 1000 ACSHIIGKPNDRDVIEFMRDAKN 1022 ACSH+IG PN IE RDAK Sbjct: 1024 ACSHVIGAPNASGQIEIWRDAKK 1046 >PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Pae Pseudomonas aeruginosa Length = 976 Score = 1183 bits (3061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 609/1013 (60%), Positives = 724/1013 (71%), Gaps = 57/1013 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAGQAQALTREDEARLNGLL 60 MLIL G+ ALSAFR +LL QL A+TG+ + HF D ALT ++E L LL Sbjct: 1 MLILRGAPALSAFRHGKLLEQLTQHVPAVTGLYAEFAHFADV--TGALTADEEQVLARLL 58 Query: 61 TYGDPFNGSD-EGDAFVVIPRFGTISPWASKATDIVRNCGMGHIHRVERGIIFRVQVKTG 119 YG + G F+V+PRFGTISPW+SKA+DI RNCG+ I R+ERGI + VQ Sbjct: 59 KYGPSVPVQEPSGRLFLVVPRFGTISPWSSKASDIARNCGLAKIDRLERGIAYYVQ---- 114 Query: 120 LLGGTKKLNEASIPAVAALLHDRMTETVLRDPQDAAGLFSELQAKPLESVDVIGGGRAAL 179 +L+E+ VAA LHDRMT+ VL + AA LFS Q +PL +VDV+GGGRAAL Sbjct: 115 -----GELSESDAQQVAARLHDRMTQLVLDRLEGAAELFSHAQPRPLTAVDVLGGGRAAL 169 Query: 180 ERANTELGLALSDDEIDYLVDAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGE 239 E+AN ELGLAL++DEIDYL+ +F + RNP DVELMMFAQANSEHCRHKIFNA W IDG+ Sbjct: 170 EKANVELGLALAEDEIDYLLKSFGELGRNPHDVELMMFAQANSEHCRHKIFNASWDIDGQ 229 Query: 240 KQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGATKGNVYEASDELTHI 299 QDKSLFGMIKNT+++ +G + AY DN+++I G RF+ T+ Y AS E I Sbjct: 230 AQDKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPDPQTR--EYAASREPVQI 287 Query: 300 LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPW 359 LMKVETHNHPTAI+PFPGASTG+GGEIRDEGATGRG+KPKAGLTGFTVSNL + QPW Sbjct: 288 LMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPW 347 Query: 360 ENARDVAQPVDQRDEHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRT 419 E YGKPERI + L IM++GPLGGAAFNNEFGRP L GYFRT Sbjct: 348 EVP------------------YGKPERIVTALDIMVEGPLGGAAFNNEFGRPALTGYFRT 389 Query: 420 YEQNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGG 475 +EQ + G +V GYHKPIM+AGGMGNI +H +K ++ VG+ LI LGGP M IG+GGG Sbjct: 390 FEQKIATPHGEEVRGYHKPIMLAGGMGNIRDEHVQKGEISVGAKLIVLGGPAMLIGLGGG 449 Query: 476 AASSMATGVNTADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNA 535 AASSMATG ++ADLDF SVQR NPEMERR QEVI+ CW LG+ NPI IHDVGAGGLSNA Sbjct: 450 AASSMATGASSADLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNA 509 Query: 536 FPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLDLFKYLCERER 595 PE+ ND RG F+LR VP +E G++P EIW NESQERYVL++ + FK +CERER Sbjct: 510 LPELINDGGRGGRFELRAVPNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERER 569 Query: 596 APFAVVGTATEERQLKVIDPEHNNNPVDMPMDVLLGKPPKMHRDVQHVEKQLPPVDLTGM 655 PFAVVG A E+RQL V D +N PVDMP++VLLGK P+MHR V + D G+ Sbjct: 570 CPFAVVGEAIEQRQLTVADSHFDNKPVDMPLEVLLGKAPRMHRAVTREAELGDDFDAAGL 629 Query: 656 DLVDVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYL 715 +L + +RVLR PAVA KSFLITIGDR++ + RDQMVGPWQVPVAD AVTA + Y Sbjct: 630 ELQESVERVLRHPAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYT 689 Query: 716 GEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDA 775 GEAMAMGERTPLA++DAPASGRMA+GE +TN+AAA + ++ DIKLSANWMAA G PG+DA Sbjct: 690 GEAMAMGERTPLALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPGEDA 749 Query: 776 ALFDTVKAVGMELCPALGISIPVGKDSLSMRSTWSDEAGAKSVTSPVSLIVSGFAPVTDV 835 L+DTVKAVGMELCP LGI+IPVGKDS+SM++ W D KSVTSPVSLIV+GFAPV DV Sbjct: 750 RLYDTVKAVGMELCPELGITIPVGKDSMSMKTRWQDNGEDKSVTSPVSLIVTGFAPVADV 809 Query: 836 RRVLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSAEDLKAFFNA 895 R+ LTPQLR DKGET LILIDLGRGKNR+G S L QV ++G PDVD AEDLKAFF Sbjct: 810 RQSLTPQLRLDKGETDLILIDLGRGKNRLGGSILAQVHGKLGRAVPDVDDAEDLKAFFAV 869 Query: 896 IQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEAEHAADWGDSKNWT 955 IQ LN + +LAYHDRSDGGL ++ EMAFAGH G+ +NLD L Sbjct: 870 IQGLNADGHILAYHDRSDGGLITSVLEMAFAGHCGVELNLDAL----------------- 912 Query: 956 TQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKP 1008 A+ R EL LFSEELGAVIQV +V+ + L C +IG+P Sbjct: 913 ---ADSREELA-AVLFSEELGAVIQVREGATPEVLAQFSAAGLDDCVAVIGQP 961 >VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Vch Vibrio cholerae Length = 972 Score = 1150 bits (2974), Expect = 0.0, Method: Compositional matrix adjust. Identities = 583/1021 (57%), Positives = 716/1021 (70%), Gaps = 60/1021 (5%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAGQAQALTREDEARLNGLL 60 M IL GS ALS FR +LLT + +TG+ ++HF D L ++ +L LL Sbjct: 1 MRILRGSPALSEFRVNKLLTACREQQLPVTGIYAEFMHFADL--KAELNPQELEKLEKLL 58 Query: 61 TYGDPFNGSD-EGDAFVVIPRFGTISPWASKATDIVRNCGMGHIHRVERGIIFRVQVKTG 119 TYG + +G +V PR GTISPW+SKATDI NCG+ I R+ERG + V+ +T Sbjct: 59 TYGPTIQEHEPQGLLLLVTPRPGTISPWSSKATDIAHNCGLHGIKRLERGTAYYVEAETA 118 Query: 120 LLGGTKKLNEASIPAVAALLHDRMTETVLRDPQDAAGLFSELQAKPLESVDVIGGGRAAL 179 L A I + ALLHDRM E V + DA LFS + P+ VDV+ GGR AL Sbjct: 119 LTA-------AQIATLEALLHDRMMEVVFAELTDAQQLFSVAEPAPMSQVDVLAGGRRAL 171 Query: 180 ERANTELGLALSDDEIDYLVDAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGE 239 E AN LGLAL++DEIDYLV++FTK RNP D+ELMMFAQANSEHCRHKIFNADWTIDG Sbjct: 172 EEANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGV 231 Query: 240 KQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGATKGNVYEASDELTHI 299 KQDKSLF MIKNT + P + AY DN++++ G+TV RF+ ++ Y D HI Sbjct: 232 KQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPESRQYTYHHED--AHI 289 Query: 300 LMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPW 359 LMKVETHNHPTAISP+PGASTG+GGEIRDEGATG G KPKAGL GFT SNL + QPW Sbjct: 290 LMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPW 349 Query: 360 ENARDVAQPVDQRDEHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRT 419 E+ +GKP RI + L IM++GPLGGAAFNNEFGRPNL GYFRT Sbjct: 350 ESD------------------FGKPSRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRT 391 Query: 420 YEQNV----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGG 475 YE+ V G +V GYHKPIMIAGGMGNI A+H +K ++PVG+ LI LGGP M IG+GGG Sbjct: 392 YEEKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPVGAKLIVLGGPAMNIGLGGG 451 Query: 476 AASSMATGVNTADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNA 535 AASSMA+G + DLDF SVQR NPEMERR QEVI+ CW LGD NPI IHDVGAGG+SNA Sbjct: 452 AASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDKNPIAFIHDVGAGGISNA 511 Query: 536 FPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLDLFKYLCERER 595 PE+ ND RG F LR VP +E G++P EIW NESQERYVLA+ E + LF +C+RER Sbjct: 512 LPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRER 571 Query: 596 APFAVVGTATEERQLKVIDPEHNNNPVDMPMDVLLGKPPKMHRDVQHVEKQLPPVDLTGM 655 AP+AVVG ATEER L + D N P+DMPMD+LLGKPPKMHR+ ++ P ++ +G+ Sbjct: 572 APYAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKMHREASTLKVSSPALERSGI 631 Query: 656 DLVDVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYL 715 +L + RVLRLPAVA+K+FLITIGDRSV + RDQMVGPWQVPVA+ AVTA + Y Sbjct: 632 ELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYH 691 Query: 716 GEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDA 775 GEAM+MGERTP+A++D AS R+AVGEAITNIAA I E+ IKLSANWM+ G PG+DA Sbjct: 692 GEAMSMGERTPVALLDFGASARLAVGEAITNIAATDIGELKRIKLSANWMSPAGHPGEDA 751 Query: 776 ALFDTVKAVGMELCPALGISIPVGKDSLSMRSTWSDEAGAKSVTSPVSLIVSGFAPVTDV 835 L++ VKAVG ELCPALGI+IPVGKDS+SM++ W + K VTSP+SLI++ FA V D+ Sbjct: 752 GLYEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVEDI 811 Query: 836 RRVLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSAEDLKAFFNA 895 R+ +TPQLR D GET LILIDLG G+NR+GA+AL QV +Q+G++ DVD+A LK FF+A Sbjct: 812 RKTVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQLGDKPADVDNAAQLKGFFDA 871 Query: 896 IQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEAEHAADWGDSKNWT 955 +Q L D+L+AYHD+ DGGL TLAEMAFAGH GI N++ L GD Sbjct: 872 VQTLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKANIETL----------GDD---- 917 Query: 956 TQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIG--KPNDRDV 1013 L ALF+EELGAV+QV ++ + V+ L ++ L AC+H+IG + +DR + Sbjct: 918 ----------ALAALFNEELGAVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLL 967 Query: 1014 I 1014 I Sbjct: 968 I 968 >HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Hin Haemophilus influenzae Length = 1011 Score = 1130 bits (2923), Expect = 0.0, Method: Compositional matrix adjust. Identities = 576/1037 (55%), Positives = 718/1037 (69%), Gaps = 63/1037 (6%) Query: 6 GSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAGQAQALTREDEARLNGLLTYGDP 65 GS ALS FR +L + Q IT V YLHFV+ Q +L ++ +L LL YG Sbjct: 31 GSPALSEFRLTQLQQKCQQYQLPITSVYAEYLHFVE--QKTSLVEDEIVKLQALLHYGSM 88 Query: 66 FNG-SDEGDAFVVIPRFGTISPWASKATDIVRNCGMGHIHRVERGIIFRVQVKTGLLGGT 124 F+ G +V PR GTIS W+SKATDI NCG+ ++R+ERGI + ++ Sbjct: 89 FSELKPAGYCLIVTPRVGTISSWSSKATDIAHNCGLSKVNRIERGIAYYFNIE------- 141 Query: 125 KKLNEASIPAVAALLHDRMTETVLRDPQDAAGLFSELQAKPLESVDVIGGGRAALERANT 184 + L EA + + LLHDRM ETVL +AA LF++ + K L ++D++ GGR ALE+AN Sbjct: 142 RDLTEAELATLKDLLHDRMLETVLNHETEAALLFTQQEPKALTTIDILNGGRQALEQANI 201 Query: 185 ELGLALSDDEIDYLVDAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGEKQDKS 244 LGLAL+DDE+DYLV++FT +RNP DVEL MFAQANSEHCRHKIFNADW IDG+KQDKS Sbjct: 202 ALGLALADDEMDYLVESFTALKRNPQDVELYMFAQANSEHCRHKIFNADWIIDGKKQDKS 261 Query: 245 LFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGATKGNVYEASDELTHILMKVE 304 LF MIKNT + P + AY DN++++EG+ V R++ Y E HILMKVE Sbjct: 262 LFKMIKNTFEQTPDFVLSAYKDNAAVMEGSKVGRWF---PDPDGQYRVHQEDVHILMKVE 318 Query: 305 THNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARD 364 THNHPTAISPFPGA+TG+GGEIRDEGATGRG+KPKAGLTGF+VSNL++ + QPWEN Sbjct: 319 THNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLTGFSVSNLVIPNFEQPWENP-- 376 Query: 365 VAQPVDQRDEHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNV 424 KP RIAS L IMID PLG AAFNNEFGRP L GYFRTYE+ V Sbjct: 377 ----------------LSKPNRIASALDIMIDAPLGSAAFNNEFGRPALLGYFRTYEEKV 420 Query: 425 ----GGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSM 480 G +V GYHKPIM+AGG+GNI + +K ++P+G+ LI LGG M IG+GGGAASSM Sbjct: 421 NSFAGKEVRGYHKPIMLAGGIGNIRGEQVQKGEIPIGAKLIVLGGAAMNIGLGGGAASSM 480 Query: 481 ATGVNTADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEIT 540 +G + DLDF SVQR NPEMERR QEVI+ CW LG++NPI IHDVGAGGLSNA PE+ Sbjct: 481 DSGKSKEDLDFASVQRENPEMERRCQEVIDRCWQLGEENPILFIHDVGAGGLSNAMPELV 540 Query: 541 NDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLDLFKYLCERERAPFAV 600 +D KRG FDLR + +E G++P EIW NESQERYVLA+ PE+L+LF LCERERAPFAV Sbjct: 541 HDGKRGGKFDLRSILCDEKGMSPLEIWCNESQERYVLAVAPENLELFTALCERERAPFAV 600 Query: 601 VGTATEERQLKVIDPEHNNNPVDMPMDVLLGKPPKMHRDV--QHVEKQLPPVDLTGMDLV 658 +G AT+ L + D +NNP+D+PM+VLLGK PKM R+V + VE Q + + + L Sbjct: 601 IGEATQAEHLILHDSHFDNNPIDLPMNVLLGKTPKMTREVLSKTVENQ--SLKIESIQLK 658 Query: 659 DVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYLGEA 718 + RVLRLP VA+K+FLITIGDRSV M RDQMVGPWQ+PV+DVAVT L+ Y GEA Sbjct: 659 EAFHRVLRLPVVAEKTFLITIGDRSVTGMVARDQMVGPWQIPVSDVAVTTASLDSYHGEA 718 Query: 719 MAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAALF 778 MA+GER+P+A++D AS R+AV EAITNIA I E+ IKLSANWM+A G G+DA L+ Sbjct: 719 MAIGERSPVALLDFSASARLAVAEAITNIAGTLIGEMKRIKLSANWMSAAGHTGEDAGLY 778 Query: 779 DTVKAVGMELCPALGISIPVGKDSLSMRSTWSDEAGAKSVTSPVSLIVSGFAPVTDVRRV 838 + VKAVG ELCPALG++IPVGKDS+SM++TW D KSVT+P+SL++S FA V DVR+ Sbjct: 779 EAVKAVGEELCPALGLTIPVGKDSMSMKTTWIDNGEQKSVTAPLSLVISAFARVEDVRKT 838 Query: 839 LTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSAEDLKAFFNAIQQ 898 LTPQLR DKG + L+LIDLG G NR+GA+AL QV +Q+G++ DV + LK F+NA+Q Sbjct: 839 LTPQLRTDKGFSSLLLIDLGEGHNRLGATALAQVYKQLGDKPADVVKVQRLKDFYNAMQT 898 Query: 899 LNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEAEHAADWGDSKNWTTQV 958 L ED+LLAYHDRSDGGL TLAEMAFAGH G+ V++ L GD+ Sbjct: 899 LVAEDKLLAYHDRSDGGLITTLAEMAFAGHCGVEVDISAL----------GDND------ 942 Query: 959 AERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFMR 1018 L LF+EELGAVIQV Q V VL+++NL H +G D E R Sbjct: 943 --------LAVLFNEELGAVIQVADSQLESVREVLKAHNLLGIIHQLGTVTADDRFEISR 994 Query: 1019 DAKNIYSQPRAELHRVW 1035 + ++S+ R+EL +W Sbjct: 995 GSHKLFSEKRSELRSIW 1011 >NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain NmA Neisseria meningitidis Z2491 Length = 1001 Score = 1129 bits (2921), Expect = 0.0, Method: Compositional matrix adjust. Identities = 595/1027 (57%), Positives = 726/1027 (70%), Gaps = 39/1027 (3%) Query: 1 MLILPGSNALSAFRTQRLLTQLQAVDAAITGVSGRYLHFVDAGQAQALTREDEARLNGLL 60 +L L G ALS FR ++LL + A+ +S + +FV G +AL +L LL Sbjct: 4 VLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFV--GSEKALDAATVEKLQALL 61 Query: 61 TYG--DPFNGSDEG-DAFVVIPRFGTISPWASKATDIVRNCGMGHIHRVERGIIFRVQVK 117 + + EG F+V PR GTISPWASKAT+I NCG+ I R+ERG+ ++ Sbjct: 62 AAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLE-- 119 Query: 118 TGLLGGTKKLNEASIPAVAALLHDRMTETVLRDPQDAAGLFSELQAKPLESVDVIGGGRA 177 L + AALLHDRMTE+VL D Q A+ LF L+++ +VDV+GGG+ Sbjct: 120 -------GALTDEQQQQWAALLHDRMTESVLPDFQTASKLFHHLESETFSTVDVLGGGKE 172 Query: 178 ALERANTELGLALSDDEIDYLVDAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTID 237 AL +ANTE+GLALS DEIDYLV+ + QRNP+DVELMMFAQANSEHCRHKIFNAD+ ++ Sbjct: 173 ALVKANTEMGLALSADEIDYLVENYQALQRNPSDVELMMFAQANSEHCRHKIFNADFILN 232 Query: 238 GEKQDKSLFGMIKNTHQLAPKGTVVAYSDNSSIIEGATVSRFYQRGATKGNVYEASDELT 297 GEKQ KSLFGMI++TH P+GTVVAY DNSS+IEGA V RFY A + Y +E T Sbjct: 233 GEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKVERFYPNAA-ENQGYRFHEEDT 291 Query: 298 HILMKVETHNHPTAISPFPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQ 357 HI+MKVETHNHPTAI+PF GA+TGAGGEIRDEGATG+GS+PKAGLTGFTVSNL + Q Sbjct: 292 HIIMKVETHNHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQ 351 Query: 358 PWENARDVAQPVDQRDEHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYF 417 PWE YGKPE I+SPL IMI+GP+GGAAFNNEFGRPNL GYF Sbjct: 352 PWEQD------------------YGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYF 393 Query: 418 RTYEQNVGGQVMGYHKPIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAA 477 RT+E+ GQV GYHKPIMIAGG+G+I A+ T K+++P G+LLIQLGGPGM IG+GGGAA Sbjct: 394 RTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAA 453 Query: 478 SSMATGVNTADLDFDSVQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFP 537 SSM TG N A LDF+SVQRGNPE+ERRAQEVI+ CW LGD NPI SIHDVGAGGLSNAFP Sbjct: 454 SSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFP 513 Query: 538 EITNDAKRGAIFDLRKVPLEESGLAPREIWSNESQERYVLAILPEHLDLFKYLCERERAP 597 E+ NDA RGA+F LR+VPLEE GL P +IW NESQERYVL+IL + LD+F+ +CERER P Sbjct: 514 ELVNDAGRGAVFKLREVPLEEHGLNPLQIWCNESQERYVLSILEKDLDIFRSICERERCP 573 Query: 598 FAVVGTATEERQLKVIDPEHNNNPVDMPMDVLLGKPPKMHRDVQHVEKQLPPVDLTGMDL 657 FAVVGTAT++ LKV D +NNPVD+P++VLLGKPPK R + V P +D+ Sbjct: 574 FAVVGTATDDGHLKVRDDLFSNNPVDLPLNVLLGKPPKTTRTDKTVAPSKKPFHAGDIDI 633 Query: 658 VDVAQRVLRLPAVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYLGE 717 + A RVLRLPAVA K+FLITIGDRSVG MT RDQMVG +Q PVAD AVT MG Y GE Sbjct: 634 TEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMVGKYQTPVADCAVTMMGFNTYRGE 693 Query: 718 AMAMGERTPLAVIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAAL 777 AM+MGE+ +A+ DAPASGRM VGEAITNIAAA I +IG+IKLSANWMAACG G+D L Sbjct: 694 AMSMGEKPTVALFDAPASGRMCVGEAITNIAAANIGDIGNIKLSANWMAACGNEGEDEKL 753 Query: 778 FDTVKAVGMELCPALGISIPVGKDSLSMRSTWSDEAGAKSVTSPVSLIVSGFAPVTDVRR 837 + TV+AV + C AL +SIPVGKDSLSM++ W D KSV SP+SLI+S FAPV DVR+ Sbjct: 754 YRTVEAVS-KACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLIISAFAPVQDVRK 812 Query: 838 VLTPQLRKDKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSAEDLKAFFNAIQ 897 +TP+L K+ ++VL+ +DLG GK RMG SA QV + + PD+D LKAF+N IQ Sbjct: 813 TVTPEL-KNVEDSVLLFVDLGFGKARMGGSAFGQVYNNMSGDAPDLDDTSRLKAFYNVIQ 871 Query: 898 QLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDIL---TMEAEHAADWGDSKNW 954 QL ED+LLAYHDRSDGGL+A L EMAFAG G+ ++L++L T H A + Sbjct: 872 QLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCGLDIDLNLLLAQTFITNHTALSQSLRTE 931 Query: 955 TTQVAERRNELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVI 1014 + E R LF+EELGAVIQV + +D++N+ L IG D + + Sbjct: 932 EVKALAEWQETIARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTL 991 Query: 1015 EFMRDAK 1021 +RD + Sbjct: 992 -IIRDGQ 997