BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0036.0097.p (1040 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MA3490 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 264 1e-69 MTH487 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 263 1e-69 TM0618 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 245 4e-64 PA2728 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 224 6e-58 MPN153 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 166 3e-40 >MA3490 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Mac Methanosarcina acetivorans str.C2A Length = 1939 Score = 264 bits (674), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 176/513 (34%), Positives = 260/513 (50%), Gaps = 64/513 (12%) Query: 431 LEHEFGKSMRYRSIRDLAGDETGAVINDLKPIWLMSPLSVSDTLPLSSTLFDVVIFDEAS 490 L +EF + + IR L + G+++ +KP +LMSPLS++ L ST FDV+IFDEAS Sbjct: 923 LLNEFNRKRGHMPIRTLM-KKAGSLVQKIKPCFLMSPLSIAQYLDPRSTRFDVIIFDEAS 981 Query: 491 QIPTEEAIPALSRAQQVIVVGDEMQLPPTSFFSAAGSGEEDEILVEEDGERIAINLDSDS 550 Q+ E+A+ AL R +QV+V+GD QLPPT FF E E + D +S Sbjct: 982 QVRPEDAVGALLRGKQVVVMGDSKQLPPTDFFDTVVDSPESE------PDDYTSAGDMES 1035 Query: 551 LLNQAARNLPATLLAWHYRSRHETLISFSNAAFYDGRLVTIPDRLRERPLEQLPRPRSDR 610 +LN R+ P L WHYRSRHE+LI+ SN FYD RL P P+++ Sbjct: 1036 ILNVCKRSFPVKTLRWHYRSRHESLIAISNQEFYDNRLYVYPS-----PMQK-------- 1082 Query: 611 DDAGTLAADLLMGSPVSFHWLEDGVYADRS----NQAEARYIAQAVREMLNRETGLSLGI 666 D +G + F +L D Y DR N+ EAR +++AV E + G SLG+ Sbjct: 1083 --------DESLG--LKFVYLPDAAY-DRGKSGVNRIEARAVSRAVFEHFQKYPGKSLGV 1131 Query: 667 VAFSEAQQSTIEAALEALASEDPEFSTRLEREYVREDDDQFNGLFIKNLENVQGDERDVI 726 F+ QQ I +EAL +P + +D+ F+KNLE +QGDERDVI Sbjct: 1132 GTFNIKQQEAILDEIEALQKANPGVD-------LNSGNDRGEHFFVKNLETIQGDERDVI 1184 Query: 727 ILSICYAPGPNGKMLMNFGPINQRGGEKRLNVIFSRARHRMAVVSSIQADAITNVHND-- 784 +LS+ + NG++ +NFGP+N+ GGE+RLNV+ +RAR + V S+ + + N Sbjct: 1185 LLSVGFGFDNNGRLSLNFGPLNREGGERRLNVLITRAREKCVVFSNFTSRDLPIDENTSF 1244 Query: 785 GAAALRSFLQFAQASATGRFDHAQTILGALNQGARKAFAAELQPDSIRDALAQTLRQRGH 844 G AL+ FL+FA++ + R+ + + +A+A+ L + G Sbjct: 1245 GLKALKVFLEFAESGTL-----------PVQSCGRQELDSPFE-----EAVAEFLTENGC 1288 Query: 845 RVQLQVGRSQFRCDLAIEG--EEGTYALAILLDNPAQAVTDTV-ERYVFRPAILRSFGWK 901 V Q+G + +R DLA+ G Y L I D + + +R R IL GWK Sbjct: 1289 EVHSQIGCAGYRLDLAVPDPRHPGRYVLGIECDGASYHSSPVARDRDRLRQQILEGLGWK 1348 Query: 902 VLDLPGRDWLRDPVAVIER-IERILAEGEEAVL 933 + + DW P E+ +E + A E+A L Sbjct: 1349 IYRVWSTDWYLHPKECREKLLETVKAAVEQAKL 1381 >MTH487 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Mth Methanothermobacter thermautotrophicus Length = 1157 Score = 263 bits (673), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 191/497 (38%), Positives = 258/497 (51%), Gaps = 73/497 (14%) Query: 453 GAVINDLKPIWLMSPLSVSDTL-PLSSTL-FDVVIFDEASQIPTEEAIPALSRAQQVIVV 510 G + +KP ++MSPLS++ L P SS L FDVVIFDEASQ+ E+A+ A RA+ +V+ Sbjct: 716 GGTVKRIKPCFMMSPLSIAQYLDPRSSQLQFDVVIFDEASQVKPEDALGAFLRARTAVVM 775 Query: 511 GDEMQLPPTSFFSAAGSGEEDEILVEEDGERIAINLDSDSLLNQAARNLPATLLAWHYRS 570 GD QLPPTSFF I EED E +A D +S+L+ R+ P +L WHYRS Sbjct: 776 GDTNQLPPTSFFDQM-------ISAEEDSEDVATAADIESILHLCKRSFPVRMLRWHYRS 828 Query: 571 RHETLISFSNAAFYDGRLVTIPDRLRERPLEQLPRPRSDRDDAGTLAADLLMGSPVSFHW 630 RHE+LI+ SN FYD RL+ P RE D +G + + Sbjct: 829 RHESLIAVSNQEFYDNRLLVYPSPARE---------------------DEELG--LHLVY 865 Query: 631 LEDGVYA---DRSNQAEARYIAQAVREMLNRE-TGLSLGIVAFSEAQQSTIEAALEALAS 686 L D VY SN EA + A+ E R + SLG+ FS AQ + I ALEA Sbjct: 866 LPDTVYERGRTSSNPLEAAAVVDAIEEHFMRYGSSRSLGVGTFSVAQMNAILEALEARLR 925 Query: 687 EDPEFSTRLEREYVREDDDQFNGLFIKNLENVQGDERDVIILSICYAPGPNGKMLMNFGP 746 E+PE LER +E D+ F FIKNLE +QGDERDVI +S+ Y G+M +NFGP Sbjct: 926 ENPE----LERIINQETDEPF---FIKNLETIQGDERDVIFISVGYGFDERGRMSLNFGP 978 Query: 747 INQRGGEKRLNVIFSRARHRMAVVSSIQADAITNVHND--GAAALRSFLQFAQASATGRF 804 +NQ GGE+RLNV+ +RAR + V ++ ++ + G AL+ FL++A+ TG Sbjct: 979 LNQEGGERRLNVLITRAREKCVVFTNFRSSDLRTGPGTPFGVRALKRFLRYAE---TGFL 1035 Query: 805 DHAQTILGALNQGARKAFAAELQPDSIRDALAQTLRQRGHRVQLQVGRSQFRCDLAIE-- 862 + T +QG L DS+ D L G V VG + FR D A++ Sbjct: 1036 ESDST---DTSQG--------LFEDSVYDFLVDA----GFEVDRGVGCAGFRVDFAVKDP 1080 Query: 863 GEEGTYALAILLDNPAQAVTDTV-ERYVFRPAILRSFGWKVLDLPGRDWLRD----PVAV 917 E G Y IL D + + +R R ILR+ GWK++ L DW R+ V Sbjct: 1081 DEPGRYIAGILTDGEMYSRAEVARDRDRLREEILRNLGWKIIHLWSSDWYRNREETQRKV 1140 Query: 918 IERIERILAEGEEAVLP 934 +R+E I+ EE V P Sbjct: 1141 SDRLEEIV---EEPVWP 1154 >TM0618 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Tma Thermotoga maritima Length = 1289 Score = 245 bits (626), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 173/506 (34%), Positives = 252/506 (49%), Gaps = 69/506 (13%) Query: 429 RELEHEFGKSMRYRSIRDLAGDETGAVINDLKPIWLMSPLSVSDTLPLSSTL--FDVVIF 486 R L E K R++ IR E ++ +KP LMSPLSVS L L + FD+VIF Sbjct: 835 RILMRETQKKRRHKPIRKFLL-EISDILRFVKPCILMSPLSVSSFLDLDKFINYFDIVIF 893 Query: 487 DEASQIPTEEAIPALSRAQQVIVVGDEMQLPPTSFFSAAGSGEEDEILVEEDGERIAINL 546 DEASQ+ T EAI A+ R +Q+IV GD QLPPT+FF + E+DE Sbjct: 894 DEASQLRTPEAISAVVRGKQIIVAGDPKQLPPTNFFKSYYELEDDE----------DERE 943 Query: 547 DSDSLLNQAA---RNLPATLLAWHYRSRHETLISFSNAAFYDGRLVTIPDRLRERPLEQL 603 DS L++ R L WHYRSR E LI+FSN FY E PL Sbjct: 944 PLDSFLDECIALPRVFKQGYLRWHYRSRDERLIAFSNHYFYG-----------ENPLITF 992 Query: 604 PRPRSDRDDAGTLAADLLMGSPVSFHWLEDGVY---ADRSNQAEARYIAQAVREMLNRET 660 P P+ D G + ++E+G + R N EA + V E + Sbjct: 993 PSPKYRNSDQG-----------IKLVYVENGTWDRAGKRVNTMEALKVVDIVIEHFQKHP 1041 Query: 661 GLSLGIVAFSEAQQSTIEAALEALASEDPEFSTRLEREYVREDDDQFNGLFIKNLENVQG 720 S+G+V + +Q IE L+ E P + +E ++ F FIK+LENVQG Sbjct: 1042 DRSIGVVTMNTSQSDLIENLLQRRLMEYPHLMDVI----FKESNEPF---FIKSLENVQG 1094 Query: 721 DERDVIILSICYAPGPNGKMLMNFGPINQRGGEKRLNVIFSRARHRMAVVSSIQADAIT- 779 DERD II+SI YA P+G++ NFGP+N GG +RLNV+ +RAR+++ +V+S++++ ++ Sbjct: 1095 DERDTIIISIGYARTPSGELFYNFGPLNNEGGWRRLNVLITRARYQIILVTSLRSEDLSR 1154 Query: 780 -NVHNDGAAALRSFLQFAQASATGRFDHAQTILGALNQGARKAFAAELQPDSIRDALAQT 838 N N G AALR++L++A+ + F R ++ D I ++A+ Sbjct: 1155 ANSENKGVAALRNYLKYAEQNCKLEF-------------CRSYGESD---DIIPTSIARQ 1198 Query: 839 LRQRGHRVQLQVGRSQFRCDLAIEGEE--GTYALAILLDNPAQA-VTDTVERYVFRPAIL 895 L G +G + + IE E G Y + I+ D A + D ++R V + +L Sbjct: 1199 LNNIGFLTDTNIGMGLCQVSVGIEDPEDPGRYKIGIIHDGKNHAMIQDVIDREVLKFKVL 1258 Query: 896 RSFGWKVLDLPGRDWLRDPVAVIERI 921 S GWK+ L +W RDP V++ I Sbjct: 1259 ESLGWKLKRLWTIEWYRDPEKVLKNI 1284 >PA2728 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Pae Pseudomonas aeruginosa Length = 886 Score = 224 bits (572), Expect = 6e-58, Method: Compositional matrix adjust. Identities = 170/539 (31%), Positives = 258/539 (47%), Gaps = 69/539 (12%) Query: 385 DINAEAIKATLQGQFSEHVRLSGLSATQLDTQGKALKKQYATGRRELEHEFGKSMRYRSI 444 D+ A+ L G+ G+ A +L ++ + TG+R S R R Sbjct: 341 DVQMRALNRELLGK--------GIDAARLGSRKQWEDVTRLTGKR--------SRRLREF 384 Query: 445 RDLAGDETGAVINDLKPIWLMSPLSVSDTLPLSSTLFDVVIFDEASQIPTEEAIPALSRA 504 +L G E G + L+P+WLM+P S LPL + LFD+VI+DEASQ+P E A+P L R Sbjct: 385 IEL-GAELG--LMSLRPVWLMNPDLASRVLPLKAGLFDMVIYDEASQMPVEFALPTLYRG 441 Query: 505 QQVIVVGDEMQLPPTSFFSAAGSGEEDEIL----------------VEEDGERIAINLDS 548 + +V GDE Q+PPT+FFS+ +E E+ E+ R I D Sbjct: 442 RVTVVSGDEKQMPPTAFFSSRVESDEAELFDGEAPDEDADEEQREAYEDTWNRREIK-DC 500 Query: 549 DSLLNQAARNLPATLLAWHYRSRHETLISFSNAAFYDGRLVTIPDRLRERPLEQLPRPRS 608 LL A LP+T L HYRS + LI FSNA+FY RL ++P R P+ Sbjct: 501 PDLLQLARNALPSTTLQIHYRSAYRELIGFSNASFYGNRL-SVPVR----------HPQ- 548 Query: 609 DRDDAGTLAADLLMGSPVSFHWLEDGVYADRSNQAEARYIAQAVREMLNRETGL--SLGI 666 A++L P+ + +G+Y ++SN+ EA + + E+ + S+G+ Sbjct: 549 ---------ANILRIKPLELIQV-NGLYQNQSNEREAERVVDYLAELWRQPYAARPSVGV 598 Query: 667 VAFSEAQQSTIEAALEALASEDPEFSTRLEREYVREDDDQFNGLFIKNLENVQGDERDVI 726 V F+ Q IE LE A +D F E R +D + G+F+KN+ENVQGDERDVI Sbjct: 599 VTFNRKQADLIEERLELRAEQDETFRAAYSEERERSEDGEDMGVFVKNVENVQGDERDVI 658 Query: 727 ILSICYAPGPNGKMLMNFGPINQRGGEKRLNVIFSRARHRMAVVSSIQADAITNVHNDGA 786 + S + G NFG + Q GGE+RLNV +RAR ++ +++S+ I+++ Sbjct: 659 VFSSTFGRNGQGSFRRNFGVLGQTGGERRLNVAVTRARRKVVMITSMPIGDISDMLGTQR 718 Query: 787 AA------LRSFLQFAQASATGRFDHAQTILGALNQGARKAFAAELQ-PDSIRDALAQTL 839 + L+ +L++A+A + G F +L L Q D + + + + Sbjct: 719 SPSSPRDYLQGYLEYARALSAGEFAGTGQLLERLQTDRSDQRRQHYQRHDGFSEIVGEYI 778 Query: 840 RQRGHRVQLQVGRSQFRCDLAIEGE-EGTYALAILLDNPAQAVTDTVE-RYVFRPAILR 896 R G F D AIE G YA+ I D P + + R ++RP++LR Sbjct: 779 RSLGWSAAPAGEGDAFGLDFAIENPATGLYAIGIECDAPCHPLLERARAREIWRPSVLR 837 >MPN153 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Mpn Mycoplasma pneumoniae Length = 1113 Score = 166 bits (420), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 138/498 (27%), Positives = 229/498 (45%), Gaps = 81/498 (16%) Query: 454 AVINDLKPIWLMSPLSVSDTLPLSSTLFDVVIFDEASQIPTEEAIPALSRAQQVIVVGDE 513 A+++ L P+ +M+ S + P L+D V+ DEASQ+ E AIP L R + I+ GD Sbjct: 669 ALLSKLFPVHIMTFESAALLTPNQRRLYDYVVIDEASQVYLERAIPILYRGAKYIIAGDT 728 Query: 514 MQLPPTSFFSAAGSGEEDEILVEEDGERIAINLDSDSLLN-QAARNLPATLLAWHYRSRH 572 QL P++FF A + DE EDG + + S SLL+ R+ TLL +HYRS Sbjct: 729 KQLKPSNFFQARAEYDVDEEF--EDG-NVEAAVHSTSLLHFLKNRSRILTLLKFHYRSDS 785 Query: 573 ETLISFSNAAFYDGRLVTIPDRLRERPLEQLPRPRSDRDDAGTLAADLLMGSPVSFHWLE 632 LI+F+N Y+ L+ + ++ D + D++ Sbjct: 786 ANLIAFTNNRIYNNELIFM--------------NKATADKQVFIVHDVI----------- 820 Query: 633 DGVYADRSNQAEARYIAQAVREMLNR-ETGLSLGIVAFSEAQQSTIEAALEALASEDPEF 691 DG++ + N EAR + Q + ++ E SLG++ F++ Q IE ++ +P Sbjct: 821 DGIWRNNRNLQEARDVVQRLEQLTQTAEYQKSLGVICFNKNQAELIEYMID--KQNNPLL 878 Query: 692 STRLER-----EYVREDDDQFNGLFIKNLENVQGDERDVIILSICYAPGPNGKMLMNFGP 746 + +R EYV GLF+KN+ENVQGDERD+II S+ Y N +GP Sbjct: 879 NEWRDRVNAQGEYV--------GLFVKNIENVQGDERDIIIFSLGYDRSVNS-----YGP 925 Query: 747 INQRGGEKRLNVIFSRARHRMAVVSSIQADAITNVHND--GAAALRSFLQFAQASATGRF 804 I+++GGE RLNV +RA+ R+ + + +A + ++ G+ L +L + +A A Sbjct: 926 ISKQGGENRLNVAITRAKQRIELFKTNRASDYNGLSSNSLGSKLLVEYLLYCEAMAN--- 982 Query: 805 DHAQTILGALNQGARKAFAAELQPDSIRDALAQTLRQRGHRVQLQVGRSQFRCDLAIEGE 864 NQG F A + + Q + ++L G QF + Sbjct: 983 ----------NQGESLDFQATQKQAPKAKYELELENQFFNELELIFG-EQFTIKRNV--N 1029 Query: 865 EGTYALAILL---DNPAQAV----------TDTVERYVFRPAILRSFGWKVLDLPGRDWL 911 EG Y+ + + +NP AV + E ++R L+ W ++++ +W Sbjct: 1030 EGAYSFSFVFYFNENPYLAVDFNPALPHSRKEVSENIIYREQFLKKRKWNLVNIWLDEWK 1089 Query: 912 RDPVAVIERIERILAEGE 929 +P V++++ L E Sbjct: 1090 LNPGGVLQKLRNCLTHSE 1107