BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0202.p (439 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2214 [GEPR] COG0477 Permeases of the major facilitator superfa... 320 6e-87 Cj0484 [GEPR] COG0477 Permeases of the major facilitator superfa... 310 3e-84 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 305 1e-82 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 305 1e-82 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 298 2e-80 >PA2214 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 440 Score = 320 bits (819), Expect = 6e-87, Method: Compositional matrix adjust. Identities = 181/421 (42%), Positives = 251/421 (59%), Gaps = 13/421 (3%) Query: 18 VLQHAVSKIKHRVLPLFVVMFIVNYIDRVNIGFVRSHLATDVGISTAAYGLGAGLFFVGY 77 +L A++ + R+LP V+M+++ +IDR N+G+ R+ L D G+ AA+ GA +FF+GY Sbjct: 10 LLSSAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGY 69 Query: 78 AIFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYLLRFLLGAAEAGFFPG 137 A FEVPSNL+L R GA+ WL RIM TWGL + AM F + TFY+LRFLLG AEAGFFPG Sbjct: 70 ACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPG 129 Query: 138 VIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQLEGA-GLHGWQWMFIIEGM 196 +I Y T W P R +A+ +F G LA +L GP+SG LL+ G GL WQW+F+ EG+ Sbjct: 130 IILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIFGLANWQWLFVTEGL 189 Query: 197 ASVVLCGFVWFWLDSMPADARWLSAEERTAITGTIVAEQAERMKHKPAHVSPLQLLRDPQ 256 + ++ +F+L P DA WLS E++ A+ G + E + P L LR Q Sbjct: 190 LASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGF--LSALRSGQ 247 Query: 257 ILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQ----VGLFNSIPWLISIVAMYAFA 312 +L FC +YF+I +++YG F+LP+ ++ SF D Q VGL +IPW+ ++V Sbjct: 248 VLKFCLVYFTIQMSVYGVVFYLPT---RIASFLDGQVGLNVGLITAIPWVCALVVTRLVT 304 Query: 313 ALAARF-RHQQAWAATALVIAAIGMFASTFGNSVYAFVSICFAAVGFKAASSLFWPLPQG 371 A R +H+Q A + AA ++ GN A ++ CFAA GF + LFW LP G Sbjct: 305 RQADRSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTG 364 Query: 372 YLDARIAAGVIALINSIGNLGGFVAPTTFGYLEQRTGSIQGGLMGLAITSLVAAGVVFLA 431 YL AA IALINS+GNLGGFVAP +E + + G+ LA L+ G LA Sbjct: 365 YLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLL--GACLLA 422 Query: 432 R 432 R Sbjct: 423 R 423 >Cj0484 [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 410 Score = 310 bits (795), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 178/408 (43%), Positives = 247/408 (60%), Gaps = 9/408 (2%) Query: 19 LQHAVSKIKHRVLPLFVVMFIVNYIDRVNIGFVRSHLATDVGISTAAYGLGAGLFFVGYA 78 L+ KI R+LPL V+MF ++ +DR NI FV+SH+ D GI AAY LGAG+FF+GYA Sbjct: 9 LELVCKKISWRILPLIVLMFCLSMLDRTNISFVKSHIEIDAGIGEAAYALGAGIFFIGYA 68 Query: 79 IFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYLLRFLLGAAEAGFFPGV 138 IFEVPSNL L + GAK WL+RIM TWGL AM F+ E +FY+LRFLLG EAGF PG+ Sbjct: 69 IFEVPSNLFLHKLGAKIWLSRIMITWGLVTMAMIFIQGEISFYVLRFLLGLTEAGFSPGI 128 Query: 139 IYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQLE-GAGLHGWQWMFIIEGMA 197 I Y + + PA R +A I+ G +A + ISG +L WQWMF+IEG Sbjct: 129 ILYLSYFFPAIYRSKAYGIYQMGVPIAFVFGSLISGFILDYTPNIYFKNWQWMFLIEGGI 188 Query: 198 SVVLCGFVWFWLDSMPADARWLSAEERTAITGTIVAEQAERMKHKPAHVSPLQLLRDPQI 257 +V++ F F+LDS P DA+WL +E+ I+ + E K S + + + Sbjct: 189 TVLVGIFCLFYLDSHPKDAKWLDIKEK-----DILLKHIEISNTKAKDYSIKDIFKSILV 243 Query: 258 LIFCFIYFSISLTIYGATFWLPSIIRKMGSFS-DFQVGLFNSIPWLISIVAMYAFAALAA 316 F F+YF I L++YG F+LPS I ++ + F+VGL N+IPW+ +A+ F +LA Sbjct: 244 WKFVFVYFCIQLSVYGVLFYLPSKIAQILQINVGFEVGLLNAIPWIFVFIALPIFTSLAD 303 Query: 317 RFRHQQAWAATALVIAAIGMFASTFGNSVYAFV-SICFAAVGFKAASSLFWPLPQGYLDA 375 + A L++A++ M ASTF ++ AF+ I AA+GF +FW LP L Sbjct: 304 KKHSWNLHAILFLLLASLSMIASTFVTNLAAFLFFISLAAIGFIVIQPIFWNLPTQVLKG 363 Query: 376 RIAAGVIALINSIGNLGGFVAPTTFGYLEQRTGSIQGGLMGLAITSLV 423 + AA IALI S+GNLGGFVAPT Y+E G ++ GL+ LA+ +++ Sbjct: 364 KGAAAAIALIGSLGNLGGFVAPTLKTYIENHFG-VEFGLIVLALIAIL 410 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 305 bits (782), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 170/433 (39%), Positives = 262/433 (60%), Gaps = 10/433 (2%) Query: 1 VETIKPSASAFAAVEPSVLQHAV-SKIKHRVLPLFVVMFIVNYIDRVNIGFVRSHLATDV 59 V+ +K S +A + P V+++ K+ R++PL ++ +I+ Y+DRVN+GF + ++ ++ Sbjct: 16 VKAMKNSNTAITS--PEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEEL 73 Query: 60 GISTAAYGLGAGLFFVGYAIFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETT 119 G S A YGLGAGLFF+GY FE+PSN+LL + GA+ W+ RIM TWGL + AFV +E Sbjct: 74 GFSEAIYGLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQ 133 Query: 120 FYLLRFLLGAAEAGFFPGVIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQL 179 FY+LRFLLGAAEAGF+PGVI Y T W P+ RG A+F +GS A I P+SG ++ Sbjct: 134 FYILRFLLGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQ 193 Query: 180 --EGAGLHGWQWMFIIEGMASVVLCGFVWFWLDSMPADARWLSAEERTAITGTIVAEQAE 237 + AG GWQWMF++E + +VVL + +LD+ A+WL+ EE+ I+ I A+ Sbjct: 194 FHDTAGWQGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADS-- 251 Query: 238 RMKHKPAHVSPLQLLRDPQILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFN 297 K K A S + L+++P + + IYF + +G T W+P++IR G S+ +GL Sbjct: 252 --KGKAASHSLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLG 309 Query: 298 SIPWLISIVAMYAFAALAARFRHQQAWAATALVIAAIG-MFASTFGNSVYAFVSICFAAV 356 +IP++ +I+AM F+ A +R ++ ++ A+G + A++ N+ + + + AA Sbjct: 310 AIPFICAIIAMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAA 369 Query: 357 GFKAASSLFWPLPQGYLDARIAAGVIALINSIGNLGGFVAPTTFGYLEQRTGSIQGGLMG 416 G A + LFW LP L AA IALINS+ NL GF++P G + T S + G+ Sbjct: 370 GVLACAPLFWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYV 429 Query: 417 LAITSLVAAGVVF 429 LA ++ A +V Sbjct: 430 LAGFLILGAAIVL 442 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 305 bits (781), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 174/427 (40%), Positives = 253/427 (59%), Gaps = 10/427 (2%) Query: 4 IKPSASAFAAVEPSVLQHAV-SKIKHRVLPLFVVMFIVNYIDRVNIGFVRSHLATDVGIS 62 + PSA A S + A K+ R++P ++ ++V Y+DRVN+GF + + D+ S Sbjct: 8 LGPSAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFS 67 Query: 63 TAAYGLGAGLFFVGYAIFEVPSNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYL 122 YGLGAG+FF+GY +FEVPSN++L R GA+ W+ RIM +WGL + AM FV + FY+ Sbjct: 68 ETVYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYV 127 Query: 123 LRFLLGAAEAGFFPGVIYYFTQWLPASERGRAMAIFLSGSALASILSGPISGGLLQLEGA 182 +RFLLG AEAGFFPG+I Y T W PA RGR F++ AL+ ++ GPISG L+ G Sbjct: 128 MRFLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGG 187 Query: 183 --GLHGWQWMFIIEGMASVVLCGFVWFWLDSMPADARWLSAEERTAITGTIVAEQAERMK 240 GL GWQWMF+IEG+ SVV+ V +LD+ + ARWL+ EE+ +T I AE+A++ Sbjct: 188 VYGLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKED 247 Query: 241 HKPAHVSPLQLLRDPQILIFCFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFNSIP 300 A + + P++ + IYFS + +YG +FWLP++I++ G VGL +IP Sbjct: 248 APIAAI-----MASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIP 302 Query: 301 WLISIVAMYAFAALAARFRHQQAWAATALVIAAIGMFAST--FGNSVYAFVSICFAAVGF 358 + ++VAM A A R R ++ A + AIG+ S N+ A ++ +G Sbjct: 303 YGAAVVAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGI 362 Query: 359 KAASSLFWPLPQGYLDARIAAGVIALINSIGNLGGFVAPTTFGYLEQRTGSIQGGLMGLA 418 LFW LP +L AA IALINS+GNL GF++P G+L+ T S G+ LA Sbjct: 363 LTTLPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLA 422 Query: 419 ITSLVAA 425 + ++ A Sbjct: 423 ASMVLGA 429 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 298 bits (763), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 168/395 (42%), Positives = 236/395 (59%), Gaps = 13/395 (3%) Query: 24 SKIKHRVLPLFVVMFIVNYIDRVNIGFVRSHLATDVGISTAAYGLGAGLFFVGYAIFEVP 83 S + R+LP ++ Y+DR+NIGF + + D+ +S AAYGLGAG+FF GY +FEVP Sbjct: 21 SVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYGLGAGIFFFGYMLFEVP 80 Query: 84 SNLLLQRFGAKAWLTRIMATWGLAATAMAFVNSETTFYLLRFLLGAAEAGFFPGVIYYFT 143 SNLLL + GA+ L+RI+ WG+ + +M FV TFY LRFLLG EAGF PG+IYY T Sbjct: 81 SNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLLGVFEAGFAPGMIYYLT 140 Query: 144 QWLPASERGRAMAIFLSGSALASILSGPISGGLL-QLEGA-GLHGWQWMFIIEGMASVVL 201 QW P RAMA+ L + L ++ GP S ++ GA GL GWQWMF+ EG+ S++L Sbjct: 141 QWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLAGWQWMFLAEGIPSILL 200 Query: 202 CGFVWFWLDSMPADARWLSAEERTAITGTIVAEQAERMKHKPAHVSPL-QLLRDPQILIF 260 + +L PADARWL+ ++ I G I + P S + L +P++ + Sbjct: 201 GIAAYGYLVDKPADARWLTDAQKAVIAGDIA-------RAAPGQASSFGKALTEPKLYVL 253 Query: 261 CFIYFSISLTIYGATFWLPSIIRKMGSFSDFQVGLFNSIPWLISIVAMYAFAALAARF-- 318 YF + +Y FWLPSI++ G FQ+GL+++IP L IVAMYA + R Sbjct: 254 AAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYALGRRSDRRGE 313 Query: 319 RHQQAWAATALVIAAIGMFASTFGNSVYAFVSICFAAVGFKAASSLFWPLPQGYLDARIA 378 RH + A TA++ A + +A+ + A +SI A+ A+ S+FW +PQ +L A Sbjct: 314 RHLHS-AITAVLGAGLLAWAAYATSFPAALISITLASAAIFASYSVFWAIPQQHLKGTAA 372 Query: 379 AGVIALINSIGNLGGFVAPTTFGYLEQRTGSIQGG 413 AG IALINSIG GGF +PT G+ ++ TGS+Q G Sbjct: 373 AGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407