BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0096.p (274 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1603 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase comple... 374 e-103 STM0154 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase comple... 312 5e-85 VC2412 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex... 311 7e-85 lpd [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, d... 311 1e-84 ZlpdA [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,... 311 1e-84 >RSc1603 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Rso Ralstonia solanacearum Length = 594 Score = 374 bits (959), Expect = e-103, Method: Compositional matrix adjust. Identities = 182/261 (69%), Positives = 215/261 (82%), Gaps = 9/261 (3%) Query: 18 FGGSTDVQCDVMVLGGGPGGYSAAFRAADLGLNTVIVERDATLGGVCLNVGCIPSKALLH 77 GGS D++CD++VLG GPGGYSAAFR+ADLG+NTV+VER TLGGVCLNVGCIPSKALLH Sbjct: 113 HGGSADLECDMLVLGSGPGGYSAAFRSADLGMNTVLVERFGTLGGVCLNVGCIPSKALLH 172 Query: 78 VAAVIDETAAMASHGVTFGKPEIDIDKLRAYKDKVIGTMTGGLAGMAKARKVQVVRGNGQ 137 AA++DE AMASHG+ + +P++D+D+LR +K+ V+G +TGGLAGMAK+RKVQVVRG G Sbjct: 173 TAAIMDEVKAMASHGIVYSEPKVDLDQLRKHKETVVGKLTGGLAGMAKSRKVQVVRGVGT 232 Query: 138 FAGPNHIEVTAED-------GSKKVVQFKHAIIAAGSSVVNLPFVPQDPRIVDSTGALEL 190 F PNH+EV G KKV++F AIIAAGS V LPF+P+DPRIVDSTGALEL Sbjct: 233 FLDPNHLEVQLTSGEGKQATGEKKVIRFAKAIIAAGSESVKLPFIPEDPRIVDSTGALEL 292 Query: 191 RQVPKRMLVIGGGIIGLEMATVYSTLGARIDVVEMMDGLMQGADRDMVKVWQKFNEKRFD 250 RQVP +MLVIGGGIIGLEMATVYSTLGARIDVVEM+D LM GADRD+VKVW K N+ RFD Sbjct: 293 RQVPGKMLVIGGGIIGLEMATVYSTLGARIDVVEMLDSLMNGADRDLVKVWDKMNKSRFD 352 Query: 251 NVMVKTKTVAVEALX--LYIR 269 VM+KTKTV VEA +Y+R Sbjct: 353 KVMLKTKTVGVEAKPDGIYVR 373 >STM0154 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Sty Salmonella typhimurium LT2 Length = 474 Score = 312 bits (800), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 158/244 (64%), Positives = 194/244 (79%), Gaps = 3/244 (1%) Query: 21 STDVQCDVMVLGGGPGGYSAAFRAADLGLNTVIVERDATLGGVCLNVGCIPSKALLHVAA 80 ST+++ V+VLG GP GYSAAFR ADLGL TVIVER TLGGVCLNVGCIPSKALLHVA Sbjct: 2 STEIKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAK 61 Query: 81 VIDETAAMASHGVTFGKPEIDIDKLRAYKDKVIGTMTGGLAGMAKARKVQVVRGNGQFAG 140 VI+E A+A HG+ FG+P+ DIDK+R +K+KVI +TGGLAGMAK RKV+VV G G+F G Sbjct: 62 VIEEAKALAEHGIVFGEPKTDIDKIRTWKEKVITQLTGGLAGMAKGRKVKVVNGLGKFTG 121 Query: 141 PNHIEVTAEDGSKKVVQFKHAIIAAGSSVVNLPFVP-QDPRIVDSTGALELRQVPKRMLV 199 N +EV E+G K V+ F +AIIAAGS + LPF+P +DPR+ DST ALEL++VPKRMLV Sbjct: 122 ANTLEVEGENG-KTVINFDNAIIAAGSRPIQLPFIPHEDPRVWDSTDALELKEVPKRMLV 180 Query: 200 IGGGIIGLEMATVYSTLGARIDVVEMMDGLMQGADRDMVKVWQKFNEKRFDNVMVKTKTV 259 +GGGIIGLEM TVY LG+ IDVVEM D ++ AD+D+VKV+ K K+F N+M++TK Sbjct: 181 MGGGIIGLEMGTVYHALGSEIDVVEMFDQVIPAADKDIVKVFTKRISKKF-NLMLETKVT 239 Query: 260 AVEA 263 AVEA Sbjct: 240 AVEA 243 >VC2412 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Vch Vibrio cholerae Length = 475 Score = 311 bits (798), Expect = 7e-85, Method: Compositional matrix adjust. Identities = 156/244 (63%), Positives = 195/244 (79%), Gaps = 3/244 (1%) Query: 21 STDVQCDVMVLGGGPGGYSAAFRAADLGLNTVIVERDATLGGVCLNVGCIPSKALLHVAA 80 S +++ V+VLG GP GYSAAFR ADLGL+TVI+ER TLGGVCLNVGCIPSKALLHVA Sbjct: 2 SKEIKAQVVVLGAGPAGYSAAFRCADLGLDTVIIERYNTLGGVCLNVGCIPSKALLHVAK 61 Query: 81 VIDETAAMASHGVTFGKPEIDIDKLRAYKDKVIGTMTGGLAGMAKARKVQVVRGNGQFAG 140 VI+E A+ HG+ FG+P+ DIDK+R +K+KVI +TGGLAGMAK RKV VV G G+F G Sbjct: 62 VIEEAKALTEHGIVFGEPKTDIDKVRLWKEKVINQLTGGLAGMAKMRKVNVVNGYGKFTG 121 Query: 141 PNHIEVTAEDGSKKVVQFKHAIIAAGSSVVNLPFVP-QDPRIVDSTGALELRQVPKRMLV 199 PN IEV E+G K VV F +AI+AAGS + LPF+P +DPRI DST ALEL++VP ++L+ Sbjct: 122 PNTIEVDGEEG-KTVVTFDNAIVAAGSRPIKLPFIPHEDPRIWDSTDALELKEVPGKLLI 180 Query: 200 IGGGIIGLEMATVYSTLGARIDVVEMMDGLMQGADRDMVKVWQKFNEKRFDNVMVKTKTV 259 +GGGIIGLEMATVY +LG++IDVVEM D L+ AD+DMVKV+ K + +F N+M++TK Sbjct: 181 MGGGIIGLEMATVYHSLGSKIDVVEMFDQLIPAADKDMVKVYTKRIKDKF-NLMLETKVT 239 Query: 260 AVEA 263 AVEA Sbjct: 240 AVEA 243 >lpd [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Eco Escherichia coli K12 Length = 474 Score = 311 bits (796), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 157/244 (64%), Positives = 195/244 (79%), Gaps = 3/244 (1%) Query: 21 STDVQCDVMVLGGGPGGYSAAFRAADLGLNTVIVERDATLGGVCLNVGCIPSKALLHVAA 80 ST+++ V+VLG GP GYSAAFR ADLGL TVIVER TLGGVCLNVGCIPSKALLHVA Sbjct: 2 STEIKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAK 61 Query: 81 VIDETAAMASHGVTFGKPEIDIDKLRAYKDKVIGTMTGGLAGMAKARKVQVVRGNGQFAG 140 VI+E A+A HG+ FG+P+ DIDK+R +K+KVI +TGGLAGMAK RKV+VV G G+F G Sbjct: 62 VIEEAKALAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTG 121 Query: 141 PNHIEVTAEDGSKKVVQFKHAIIAAGSSVVNLPFVP-QDPRIVDSTGALELRQVPKRMLV 199 N +EV E+G K V+ F +AIIAAGS + LPF+P +DPRI DST ALEL++VP+R+LV Sbjct: 122 ANTLEVEGENG-KTVINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLLV 180 Query: 200 IGGGIIGLEMATVYSTLGARIDVVEMMDGLMQGADRDMVKVWQKFNEKRFDNVMVKTKTV 259 +GGGIIGLEM TVY LG++IDVVEM D ++ AD+D+VKV+ K K+F N+M++TK Sbjct: 181 MGGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKKF-NLMLETKVT 239 Query: 260 AVEA 263 AVEA Sbjct: 240 AVEA 243 >ZlpdA [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes EcZ Escherichia coli O157:H7 EDL933 Length = 474 Score = 311 bits (796), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 157/244 (64%), Positives = 195/244 (79%), Gaps = 3/244 (1%) Query: 21 STDVQCDVMVLGGGPGGYSAAFRAADLGLNTVIVERDATLGGVCLNVGCIPSKALLHVAA 80 ST+++ V+VLG GP GYSAAFR ADLGL TVIVER TLGGVCLNVGCIPSKALLHVA Sbjct: 2 STEIKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAK 61 Query: 81 VIDETAAMASHGVTFGKPEIDIDKLRAYKDKVIGTMTGGLAGMAKARKVQVVRGNGQFAG 140 VI+E A+A HG+ FG+P+ DIDK+R +K+KVI +TGGLAGMAK RKV+VV G G+F G Sbjct: 62 VIEEAKALAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTG 121 Query: 141 PNHIEVTAEDGSKKVVQFKHAIIAAGSSVVNLPFVP-QDPRIVDSTGALELRQVPKRMLV 199 N +EV E+G K V+ F +AIIAAGS + LPF+P +DPRI DST ALEL++VP+R+LV Sbjct: 122 ANTLEVEGENG-KTVINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLLV 180 Query: 200 IGGGIIGLEMATVYSTLGARIDVVEMMDGLMQGADRDMVKVWQKFNEKRFDNVMVKTKTV 259 +GGGIIGLEM TVY LG++IDVVEM D ++ AD+D+VKV+ K K+F N+M++TK Sbjct: 181 MGGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKKF-NLMLETKVT 239 Query: 260 AVEA 263 AVEA Sbjct: 240 AVEA 243