BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0033.0032.p (280 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PAB2381 [GER] COG0697 Permeases of the drug/metabolite transport... 104 2e-22 PH0593 [GER] COG0697 Permeases of the drug/metabolite transporte... 97 5e-20 FN0674 [GER] COG0697 Permeases of the drug/metabolite transporte... 91 4e-18 FN1465 [GER] COG0697 Permeases of the drug/metabolite transporte... 89 8e-18 AGc3999 [GER] COG0697 Permeases of the drug/metabolite transport... 79 1e-14 >PAB2381 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pab Pyrococcus abyssi Length = 280 Score = 104 bits (260), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 135/265 (50%), Gaps = 16/265 (6%) Query: 2 IWGGSYSAAKIATEQLPVLQFLVLRFGLTFLLLVPALRSITSVPAWKRSLAGALVLGMVL 61 IWG ++ K+ E P + F+ RF + LL++ LR ++L G LV G+ L Sbjct: 17 IWGSTFPVMKLGIEDYPPITFVAFRFLIASLLMLIFLRKDIKT---SQALPGLLV-GLSL 72 Query: 62 LAIFICETVGVSLTTASNAAFLISLCVVFTPWCEWLLLGQRPKRSALIACALSFVGAALL 121 F + VG+ TT+SN+AF+ SL +VFTP+ LLL R K +A L+ +G L+ Sbjct: 73 FLGFSFQVVGLKYTTSSNSAFITSLYMVFTPFVAILLLKTRVKLIDWVALGLALLGTYLI 132 Query: 122 AFQDGITLSHLSWGDALMVVAALLRGVMVCLTRRQGLRFGLPALTLTAVQMGVMTAGSLV 181 + + + ++GD L V+AAL + L FG + L Q+ + SL Sbjct: 133 S-----NVGNFNYGDMLTVLAALSFAFQIVLVE----YFGNLGIGLAFWQVFWNSMFSLA 183 Query: 182 LMTVLPGQRWMPLPASASFWWAMAFLVLLCTIVAFFVQNHAAARTSASRVALLMGSEPLW 241 + G +P+P S +A+ + ++ T +AF VQ + + R A++ +EP++ Sbjct: 184 YAAIFEG---LPMPREGSTLFAIIYTAIMATAIAFAVQVKYQPKIDSHRAAIIYSAEPVF 240 Query: 242 GALIAVVWMKEQMSLQGWMGGLLIV 266 G + + + E +S +G++G LLI+ Sbjct: 241 GHFFSFLILGEVLSWKGYIGALLIL 265 >PH0593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pho Pyrococcus horikoshii Length = 284 Score = 97.1 bits (240), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 77/267 (28%), Positives = 133/267 (49%), Gaps = 15/267 (5%) Query: 2 IWGGSYSAAKIATEQLPVLQFLVLRFGLTFLLLVPALRSITSVPAWKRSLAGALVLGMVL 61 IWG ++ KI + P + F+ RF L ++L L+ + K + ++G+ L Sbjct: 20 IWGTTFPVMKIGIKDFPPVSFIAFRFFLASIILAIVLKDKIT----KDQIFPGFLIGLSL 75 Query: 62 LAIFICETVGVSLTTASNAAFLISLCVVFTPWCEWLLLGQRPKRSALIACALSFVGAALL 121 A F + VG+ TTASN+AF+ SL +VFTP+ + LL + R +A A++ +G L+ Sbjct: 76 FAGFGFQVVGLKYTTASNSAFITSLYMVFTPFVAFALLKSKITRVDALALAIAVLGTYLI 135 Query: 122 AFQDGITLSHLSWGDALMVVAALLRGVMVCLTRRQGLRFGLPALTLTAVQMGVMTAGSLV 181 + G +L +LS+GD L ++AAL + L + L L Q+ SLV Sbjct: 136 S---GASL-NLSYGDLLTILAALSFAFQIVLIE----YYKDLGLGLAFWQIFWNFIFSLV 187 Query: 182 LMTVLPGQRWMPLPASASFWWAMAFLVLLCTIVAFFVQNHAAARTSASRVALLMGSEPLW 241 +PLP S +A+ + ++ T +AF Q + + R A+L +EP++ Sbjct: 188 YSIYFES---LPLPKEGSTVFAILYTGIVATALAFLGQVKYQPKIESHRAAVLYSAEPVF 244 Query: 242 GALIAVVWMKEQMSLQGWMGGLLIVGA 268 G + + + E + +G++G LI+ A Sbjct: 245 GYFFSFLILGEILPFEGYVGAFLILVA 271 >FN0674 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Fnu Fusobacterium nucleatum Length = 282 Score = 90.5 bits (223), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 134/275 (48%), Gaps = 15/275 (5%) Query: 1 VIWGGSYSAAKIATEQLPVLQFLVLRFGLTFLLLVPALRSITSVPAWKRSLAGALVLGMV 60 + +G +Y KI + + RF + F++ + L+ P + +L+LG + Sbjct: 16 IFFGMTYVLTKICLKYSTEFHIISFRFLIAFVVSLIFLQK-KIFPVKRTEFLYSLLLGAL 74 Query: 61 LLAIFICETVGVSLTTASNAAFLISLCVVFTPWCEWLLLGQRPKRSALIACALSFVGAAL 120 L +FI T+GV TTA+NA+FLISL V+F P+ W ++PK+ + ++ +G L Sbjct: 75 LFLVFIAMTIGVKYTTATNASFLISLSVIFIPFFSWFFNKEKPKKRIFVVLIIALIGIIL 134 Query: 121 LAFQDGITLSHLSWGDALMVVAALLRGVMVCLTRRQGLRFGLPALTLTAVQMGVMTAGSL 180 L + H+ GD L ++ A L V +T + ++ P +GV+ G + Sbjct: 135 LTLDKNLEF-HI--GDILCLICATLFTFYVIMTEKI-VKNNNPT------ALGVLQFGWV 184 Query: 181 VLMTVL---PGQRWMPLPASASFWWAMAFLVLLCTIVAFFVQNHAAARTSASRVALLMGS 237 L + L P + ++ +P + FW +M L + CT + Q A S++ V ++ Sbjct: 185 FLFSFLVQYPIESFV-IPKNKFFWLSMVLLGIFCTAFGYIAQTIAQKNLSSTVVGFILSL 243 Query: 238 EPLWGALIAVVWMKEQMSLQGWMGGLLIVGATGWV 272 EP++ + ++ E +S Q ++G L++ + +V Sbjct: 244 EPVFSGIFGYFFLNEYLSFQQYIGAFLLLISVIYV 278 >FN1465 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Fnu Fusobacterium nucleatum Length = 291 Score = 89.4 bits (220), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 68/268 (25%), Positives = 137/268 (51%), Gaps = 12/268 (4%) Query: 1 VIWGGSYSAAK-IATEQLPVLQFLVLRFGLT-FLLLVPALRSITSVPAWKRSLAGALVLG 58 +I G SY K I Q P + + RF LT +LL+ ++ ++ + L L+ G Sbjct: 17 IIRGSSYIFIKNIIDNQSP-FEIIFFRFFLTEIILLIFYIKEFKTLNHY--DLIFGLLAG 73 Query: 59 MVLLAIFICETVGVSLTTASNAAFLISLCVVFTPWCEWLLLGQRPKRSALIACALSFVGA 118 + L + F +T G+ TT S +FL SL +V P +++ + K++ + L VG Sbjct: 74 IFLFSAFAFQTYGLKYTTVSKQSFLTSLYIVIIPLLDFIFFKNKIKKNVIALFFLILVGL 133 Query: 119 ALLAFQDGITLS-HLSWGDALMVVAALLRGVMVCLTRRQGLRFGLPALTLTAVQMGVMTA 177 ++F+D +L++GD L ++ AL + + L + +F + + +T +QM +T Sbjct: 134 LFISFKDFKNFEFYLNFGDILTILCALGFALNILLFSKIK-KFNINVINITIIQM--LTI 190 Query: 178 GSLVLMTVLPGQRWMPLPASASFWWAMAFLVLLCTIVAFFVQNHAAARTSASRVALLMGS 237 G L + + ++ + + S +++ +L+L+CT++ F +QN + A + L++ Sbjct: 191 GILAFIFQIIFEKKV---INFSMNFSLIYLILICTMLNFTIQNISQKYVPAHIIGLILSL 247 Query: 238 EPLWGALIAVVWMKEQMSLQGWMGGLLI 265 E ++G + A++++ E +S +G LI Sbjct: 248 EAIFGTVFAIIFLNETISQNFIIGTFLI 275 >AGc3999 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 300 Score = 79.0 bits (193), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 131/270 (48%), Gaps = 16/270 (5%) Query: 2 IWGGSYSAAKIATEQLPVLQFLVLRFGLTFLLLVP----ALRSITSVPAWKRSLAGALVL 57 IWGG + A A + F+ LRF + + ++P RS+ S P +R + +++ Sbjct: 16 IWGGGFVAQSSAMSSIGPFWFVGLRFAIAAIAVLPFALMETRSLKS-PPRRREIGSFILV 74 Query: 58 GMVLLAIFICETVGVSLTTASNAAFLISLCVVFTPWCEWLLLGQRPKRSALIACALSFVG 117 G+ L + VG+ TT +N++FL L V+F P +L + P + CAL +G Sbjct: 75 GLALFGGATTQQVGLLTTTVTNSSFLTGLYVIFVPVIAVVLYRRHPHW-VVWPCALMMLG 133 Query: 118 AALLAFQDGITLSHLSWGDALMVVAALLRGVMVCLTRRQGLRFGLPALTLTAVQMGVMTA 177 L G L+ GD L ++ A + + L R G P L L+ Q V + Sbjct: 134 GIFLL--SGGAFETLTTGDILSIICAFFWAIQITLAGRFVSESGRP-LALSFTQFAVCS- 189 Query: 178 GSLVLMTVLPGQRWMPLPASASFWWAMAFLV--LLCTIVAFFVQNHAAARTSASRVALLM 235 L++ + G + P+ +A M L L+ + +AF +Q T+A + A+ + Sbjct: 190 ----LLSCMIGVVFEPISMAAIEASMMEILYVGLVSSGLAFVLQVIGQRYTTAPQAAIFL 245 Query: 236 GSEPLWGALIAVVWMKEQMSLQGWMGGLLI 265 SE L+GAL+A +++KE +S G++G L+I Sbjct: 246 SSEALFGALMASIFLKETISSAGYVGCLII 275