BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0112.p (1049 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1614 0.0 PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1451 0.0 YPO2848 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pe... 1431 0.0 yegN [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1380 0.0 ZyegN [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia c... 1378 0.0 >RSp1198 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1041 Score = 1614 bits (4179), Expect = 0.0, Method: Compositional matrix adjust. Identities = 806/1042 (77%), Positives = 926/1042 (88%), Gaps = 1/1042 (0%) Query: 1 MNPSRQFILRPVATSLLMLAILLVGIVAYRLLPLSALPEVDYPTIQVVTLYPGASPDVMT 60 MNPSR FILRPVAT+LLM+AILL G+VAYR+LPLSALPEVDYPTIQV TLYPGASPDVMT Sbjct: 1 MNPSRIFILRPVATTLLMVAILLSGLVAYRMLPLSALPEVDYPTIQVTTLYPGASPDVMT 60 Query: 61 SSVTAPLERQFGQMPGLKQMSSTSSGGASVITLQFNLDLSLDVAEQEVQAAINAGSNLLP 120 SS+TAPLERQFGQMPGLKQM+S SSGGASVITLQF+L LSLD+AEQEVQAAINA NLLP Sbjct: 61 SSITAPLERQFGQMPGLKQMTSASSGGASVITLQFDLSLSLDIAEQEVQAAINAAGNLLP 120 Query: 121 SDLPMPPVYSKVNPADTPIITLAVTSKTIPLPKVQDLIDTRLAQKISQLSGVGLVSLSGG 180 +DLPMPP+YSKVNPAD PI+TLA+TS+T+PLPK++D++DTR+AQK+SQL G+GLVS+SGG Sbjct: 121 TDLPMPPIYSKVNPADAPILTLAITSRTLPLPKLEDIVDTRVAQKLSQLPGIGLVSISGG 180 Query: 181 QRPAVRMQLNPRAVAALGLNLDDVRTAIGNANVNQAKGSFDGPTRASTIDANDQLRSADE 240 QRPAVR+Q N +A+AALGL++DD+RTAIGNANVN AKGSFDGP RASTIDANDQLRSA E Sbjct: 181 QRPAVRIQANTQALAALGLSIDDIRTAIGNANVNGAKGSFDGPMRASTIDANDQLRSAAE 240 Query: 241 YRNLIIAYKNGAPIRVSDVADVIDGAENVRLGAWANQQPAVIVNIQRQPGANVIAVVDSI 300 Y +I+AYKNGAPIR++DVA +IDGAEN +L AWAN PA+I+N+QRQPGANVI VV+ Sbjct: 241 YGTMIVAYKNGAPIRLTDVAQIIDGAENSKLAAWANTTPAIILNVQRQPGANVIDVVNRA 300 Query: 301 KKILPQLQASLPGAIDVHILTDRTTTIRASVEDVKFELLLSVALVVMVIFVFLRNVPATI 360 K +LPQL+ +LP IDV +LTDRTTTIRASV DV+FELLL+VALVVMVIF+FLRN+PATI Sbjct: 301 KALLPQLKDTLPANIDVAVLTDRTTTIRASVADVQFELLLAVALVVMVIFLFLRNIPATI 360 Query: 361 IPSVAVPLSLVGTFAVMYLAGFSINNLTLMALTIATGFVVDDAIVMIENISRYIEEGMKP 420 IP+VAVPLSLVGTF VMYLAGFS+NNLTLMALTIATGFVVDDAIVMIENI+RYIE+G P Sbjct: 361 IPAVAVPLSLVGTFGVMYLAGFSVNNLTLMALTIATGFVVDDAIVMIENIARYIEDGDPP 420 Query: 421 MQAALKGAEQIGFTIISLTFSLIAVLIPLLFMGDVVGRLFHEFAVTLAVSILISAVVSLT 480 M+AALKGA QIGFTIISLTFSLIAVLIPLLFM DVVGRLF EFA+TLAVSILISAVVSLT Sbjct: 421 MEAALKGARQIGFTIISLTFSLIAVLIPLLFMSDVVGRLFREFAITLAVSILISAVVSLT 480 Query: 481 LTPMMCARLLRHQPEEQQGWFYHKSQAFFDRIIARYGVMLEWVLERQKLTLLVAVATLGL 540 LTPMMCARLLRH PE +Q FYH + FFD +IA+YG ML+WVL+RQ+ TLLVA+ TL L Sbjct: 481 LTPMMCARLLRHIPEPEQTRFYHAAGQFFDNVIAQYGRMLQWVLDRQRTTLLVAIGTLAL 540 Query: 541 TVLLYVFVPKGFFPLQDTGVIQGISEATQSISFGAMGEKQQQLAKVVLEDPAVESLSSFI 600 T LLYV+VPKGFFP+QDTGVIQGIS+ATQSISF AM E+QQ+LA+V+L+DPAVESLSSFI Sbjct: 541 TGLLYVYVPKGFFPVQDTGVIQGISDATQSISFPAMAERQQKLAEVILKDPAVESLSSFI 600 Query: 601 GVDGTNATLNSGRMLINLKPHEARDVSASDVIRRLQPKLTQAVPGVTLYMQPVQDLTIED 660 GVDGTN TLNSGRMLINLKP +ARD A+++I+RLQP+L + V G++L+MQPVQDLTIED Sbjct: 601 GVDGTNTTLNSGRMLINLKPKDARDADATEIIQRLQPELAK-VGGISLFMQPVQDLTIED 659 Query: 661 SVSRTQYQFTLEDADPGTLSTWVPKLIARLQQVPQLADVATNLQDQGLQAYIQIDRNAAS 720 VSRTQYQFT+ED DP LS WVP+L+ RLQQ +L DVA++LQD GL+AY+QIDR+ A+ Sbjct: 660 RVSRTQYQFTVEDPDPNNLSKWVPRLVERLQQTGELRDVASDLQDNGLRAYVQIDRDKAA 719 Query: 721 RLGITTAAIDNALYNAFGQRLISTIYTQSNLYRVVMEVKPEFQRGPEALDSIFLVTSAGG 780 G+TTAA+D+ALY+A+GQRLISTI+TQSN YRVV+E P+ Q+GP++L + + ++ G Sbjct: 720 VYGVTTAAVDSALYSAYGQRLISTIFTQSNQYRVVLEAAPQLQKGPQSLYDLRVASTGGQ 779 Query: 781 KVPLSSIATVTERTAPLVVNHIGQFPAATVSFNLAKGASLGEAVKAIKAAEDEIGMPDST 840 +VPL + ATV E+ LVVNH GQFP+AT+SFNLA+GASLG AV AI AAE IG+P S Sbjct: 780 QVPLGAFATVVEQPGSLVVNHQGQFPSATISFNLARGASLGAAVDAINAAEQAIGLPASM 839 Query: 841 ITNFQGAALAFQASLSNTLWLILAAIITMYIVLGVLYESYIHPITILSTLPSAGVGALLS 900 T+FQGAALAFQ+SLSN LWLILAAIITMYIVLGVLYES IHP+TILSTLPSAGVGALLS Sbjct: 840 QTSFQGAALAFQSSLSNELWLILAAIITMYIVLGVLYESTIHPVTILSTLPSAGVGALLS 899 Query: 901 LMISGTDLGIIGIIGIILLIGIVKKNAIMMIDFALEAERHQGKSPREAIYQACLLRFRPI 960 L++SG D+GII IIGIILLIGIVKKNAIMMIDFALEAER QG +PR+AIYQACLLRFRPI Sbjct: 900 LLVSGKDMGIIAIIGIILLIGIVKKNAIMMIDFALEAEREQGMAPRDAIYQACLLRFRPI 959 Query: 961 LMTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRR 1020 LMTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYL FDSLG R Sbjct: 960 LMTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLAFDSLGHR 1019 Query: 1021 LRARFGQRAPGHGGEDDDDSKP 1042 LR +RA G D S+P Sbjct: 1020 LRDWRERRAARRTGADQSGSQP 1041 >PA2527 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1043 Score = 1451 bits (3756), Expect = 0.0, Method: Compositional matrix adjust. Identities = 751/1028 (73%), Positives = 892/1028 (86%), Gaps = 1/1028 (0%) Query: 1 MNPSRQFILRPVATSLLMLAILLVGIVAYRLLPLSALPEVDYPTIQVVTLYPGASPDVMT 60 MNPSR FILRPVAT+LLM+AILL G++AYR LP+SALPEVDYPTIQVVTLYPGASP++MT Sbjct: 1 MNPSRPFILRPVATTLLMVAILLSGLIAYRFLPISALPEVDYPTIQVVTLYPGASPEIMT 60 Query: 61 SSVTAPLERQFGQMPGLKQMSSTSSGGASVITLQFNLDLSLDVAEQEVQAAINAGSNLLP 120 SS+TAPLE Q GQ+PGL +MSS+SSGGASVITLQF+L +LDVAEQEVQAAINA +LLP Sbjct: 61 SSITAPLENQLGQIPGLNEMSSSSSGGASVITLQFSLQSNLDVAEQEVQAAINAAQSLLP 120 Query: 121 SDLPMPPVYSKVNPADTPIITLAVTSKTIPLPKVQDLIDTRLAQKISQLSGVGLVSLSGG 180 +DLP PV+SKVNPAD PI+TLAV S +PLP++QDL+DTRLAQKISQ+SGVGLVS+SGG Sbjct: 121 NDLPNQPVFSKVNPADAPILTLAVMSDGMPLPQIQDLVDTRLAQKISQISGVGLVSISGG 180 Query: 181 QRPAVRMQLNPRAVAALGLNLDDVRTAIGNANVNQAKGSFDGPTRASTIDANDQLRSADE 240 QRPAVR++ NP A+AA GL+L+D+R+ + + N+N KGSFDGPTRAST+DANDQLRSAD Sbjct: 181 QRPAVRVRANPTALAAAGLSLEDLRSTVTSNNLNGPKGSFDGPTRASTLDANDQLRSADA 240 Query: 241 YRNLIIAYKNGAPIRVSDVADVIDGAENVRLGAWANQQPAVIVNIQRQPGANVIAVVDSI 300 YR+LIIAYKNG+P+R+ DVA V D AENVRL AWAN PAV++NIQRQPGANVI VVD I Sbjct: 241 YRDLIIAYKNGSPLRIRDVASVEDDAENVRLAAWANNLPAVVLNIQRQPGANVIEVVDRI 300 Query: 301 KKILPQLQASLPGAIDVHILTDRTTTIRASVEDVKFELLLSVALVVMVIFVFLRNVPATI 360 K +LPQLQ++LPG +DV +LTDRTTTIRASV+DV+FEL L+VALVVMV F+FLRNV AT+ Sbjct: 301 KALLPQLQSTLPGNLDVQVLTDRTTTIRASVKDVQFELALAVALVVMVTFLFLRNVYATL 360 Query: 361 IPSVAVPLSLVGTFAVMYLAGFSINNLTLMALTIATGFVVDDAIVMIENISRYIEEGMKP 420 IPS AVPLSL+GTF VMYL+GFSINNLTLMALTIATGFVVDDAIVM+ENI+RY+E+G P Sbjct: 361 IPSFAVPLSLIGTFGVMYLSGFSINNLTLMALTIATGFVVDDAIVMVENIARYLEQGDSP 420 Query: 421 MQAALKGAEQIGFTIISLTFSLIAVLIPLLFMGDVVGRLFHEFAVTLAVSILISAVVSLT 480 ++AALKG++QIGFTIISLTFSLIAVLIPLLFMGDV GRLF EFA+TLAV+ILIS VSLT Sbjct: 421 LEAALKGSKQIGFTIISLTFSLIAVLIPLLFMGDVAGRLFREFAITLAVAILISGFVSLT 480 Query: 481 LTPMMCARLLRHQPEEQQGWFYHKSQAFFDRIIARYGVMLEWVLERQKLTLLVAVATLGL 540 LTPM+ A+LLRH E+QQG F + D +IA+Y L VL Q LTLLVA+ATL L Sbjct: 481 LTPMLSAKLLRHIDEDQQGRFARAAGRVIDGLIAQYAKALRVVLRHQPLTLLVAIATLAL 540 Query: 541 TVLLYVFVPKGFFPLQDTGVIQGISEATQSISFGAMGEKQQQLAKVVLEDPAVESLSSFI 600 T LLY+ +PKGFFP+QDTGVIQG++EA QSISF AM E+Q+ LA+VVL+DPAV SLSS+I Sbjct: 541 TALLYLAMPKGFFPVQDTGVIQGVAEAPQSISFQAMSERQRALAEVVLKDPAVASLSSYI 600 Query: 601 GVDGTNATLNSGRMLINLKPHEARDVSASDVIRRLQPKLTQAVPGVTLYMQPVQDLTIED 660 GVDG+N TLN+GR+LINLKPH RDV+AS+VI+RLQP+L +PG+ LYMQPVQDLTIED Sbjct: 601 GVDGSNPTLNTGRLLINLKPHSERDVTASEVIQRLQPELDH-LPGIKLYMQPVQDLTIED 659 Query: 661 SVSRTQYQFTLEDADPGTLSTWVPKLIARLQQVPQLADVATNLQDQGLQAYIQIDRNAAS 720 V+RTQYQFTL+DADP L+ WVPKL+ARLQ++PQLADVA++ QD+GLQAY+ IDR+ AS Sbjct: 660 RVARTQYQFTLQDADPDVLAEWVPKLVARLQELPQLADVASDWQDKGLQAYLNIDRDTAS 719 Query: 721 RLGITTAAIDNALYNAFGQRLISTIYTQSNLYRVVMEVKPEFQRGPEALDSIFLVTSAGG 780 RLG+ + ID+ LYNAFGQRLISTI+TQ+ YRVV+EV P+FQ GP+AL+ +++ +S G Sbjct: 720 RLGVKLSDIDSVLYNAFGQRLISTIFTQATQYRVVLEVAPQFQLGPQALEQLYVPSSDGT 779 Query: 781 KVPLSSIATVTERTAPLVVNHIGQFPAATVSFNLAKGASLGEAVKAIKAAEDEIGMPDST 840 +V LSS+A V ER L +NHI QFP+AT+SFNLAKG SLGEAV+AI+ E + +P S Sbjct: 780 QVRLSSLAKVEERHTLLAINHIAQFPSATLSFNLAKGYSLGEAVEAIRGVEASLELPLSM 839 Query: 841 ITNFQGAALAFQASLSNTLWLILAAIITMYIVLGVLYESYIHPITILSTLPSAGVGALLS 900 +F+GAALAF+ASLSNTL LILA+++TMYIVLG+LYES+IHP+TILSTLPSAGVGALL+ Sbjct: 840 QGSFRGAALAFEASLSNTLLLILASVVTMYIVLGILYESFIHPVTILSTLPSAGVGALLA 899 Query: 901 LMISGTDLGIIGIIGIILLIGIVKKNAIMMIDFALEAERHQGKSPREAIYQACLLRFRPI 960 LM++G ++GI+ IIGIILLIGIVKKNAIMMIDFAL+AER++GK P EAIYQACLLRFRPI Sbjct: 900 LMLAGQEIGIVAIIGIILLIGIVKKNAIMMIDFALDAERNEGKPPHEAIYQACLLRFRPI 959 Query: 961 LMTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRR 1020 LMTTMAALLGALPLML G G+ELRQPLGITMVGGLL+SQVLTLFTTPVIYL FD L RR Sbjct: 960 LMTTMAALLGALPLMLAGGAGAELRQPLGITMVGGLLLSQVLTLFTTPVIYLYFDRLARR 1019 Query: 1021 LRARFGQR 1028 A QR Sbjct: 1020 WAAWRKQR 1027 >YPO2848 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pestis Length = 1052 Score = 1431 bits (3705), Expect = 0.0, Method: Compositional matrix adjust. Identities = 729/1039 (70%), Positives = 857/1039 (82%), Gaps = 6/1039 (0%) Query: 3 PSRQFILRPVATSLLMLAILLVGIVAYRLLPLSALPEVDYPTIQVVTLYPGASPDVMTSS 62 PSR FILRPVAT+L M+AILL GI+ YR LP+SALPEVDYPTIQVVTLYPGASPDV+TSS Sbjct: 12 PSRLFILRPVATTLFMIAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVVTSS 71 Query: 63 VTAPLERQFGQMPGLKQMSSTSSGGASVITLQFNLDLSLDVAEQEVQAAINAGSNLLPSD 122 +TAPLERQFGQM GLKQM+S SSGGASVITLQF L L LDVAEQEVQAAINA +NLLPSD Sbjct: 72 ITAPLERQFGQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSD 131 Query: 123 LPMPPVYSKVNPADTPIITLAVTSKTIPLPKVQDLIDTRLAQKISQLSGVGLVSLSGGQR 182 LP PP+Y+KVNPAD PI+TLAVT+ IP+ +V+D+++TR+AQKISQ++GVGLV+LSGGQR Sbjct: 132 LPYPPIYNKVNPADPPILTLAVTATAIPMTQVEDMVETRIAQKISQVTGVGLVTLSGGQR 191 Query: 183 PAVRMQLNPRAVAALGLNLDDVRTAIGNANVNQAKGSFDGPTRASTIDANDQLRSADEYR 242 PAVR++LN AVAALGL+ + +RTAI NANVN AKGS DGPTR+ T+ ANDQ++SA+EYR Sbjct: 192 PAVRVKLNAPAVAALGLDSETIRTAISNANVNSAKGSLDGPTRSVTLSANDQMKSAEEYR 251 Query: 243 NLIIAYKNGAPIRVSDVADVIDGAENVRLGAWANQQPAVIVNIQRQPGANVIAVVDSIKK 302 +LIIAY+NGAPIR+ DVA + GAEN +L AWAN Q A+++NIQRQPG NVIA DSI++ Sbjct: 252 DLIIAYQNGAPIRLQDVATIEQGAENNKLAAWANTQSAIVLNIQRQPGVNVIATADSIRE 311 Query: 303 ILPQLQASLPGAIDVHILTDRTTTIRASVEDVKFELLLSVALVVMVIFVFLRNVPATIIP 362 +LP+L SLP ++DV +LTDRT+TIRASV DV+FELLL++ALVVMVI++FLRN ATIIP Sbjct: 312 MLPELIKSLPKSVDVKVLTDRTSTIRASVNDVQFELLLAIALVVMVIYLFLRNAAATIIP 371 Query: 363 SVAVPLSLVGTFAVMYLAGFSINNLTLMALTIATGFVVDDAIVMIENISRYIEEGMKPMQ 422 S+AVPLSLVGTFA MY GFSINNLTLMALTIATGFVVDDAIV+IENISRYIE+G KP+ Sbjct: 372 SIAVPLSLVGTFAAMYFLGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLD 431 Query: 423 AALKGAEQIGFTIISLTFSLIAVLIPLLFMGDVVGRLFHEFAVTLAVSILISAVVSLTLT 482 AALKGA +IGFTIISLTFSLIAVLIPLLFM D+VGRLF EFAVTLAV+ILISAVVSLTLT Sbjct: 432 AALKGAGEIGFTIISLTFSLIAVLIPLLFMEDIVGRLFREFAVTLAVAILISAVVSLTLT 491 Query: 483 PMMCARLLRHQPEEQQGWFYHKSQAFFDRIIARYGVMLEWVLERQKLTLLVAVATLGLTV 542 PMMCAR+L ++ +Q S+ FFD +IA Y V L+ VL LTL VA +TL LTV Sbjct: 492 PMMCARMLSYESLRKQNRLSRASEKFFDWVIAHYAVALKKVLNHPWLTLSVAFSTLVLTV 551 Query: 543 LLYVFVPKGFFPLQDTGVIQGISEATQSISFGAMGEKQQQLAKVVLEDPAVESLSSFIGV 602 +LY+ +PKGFFPLQD G+IQG EA QS+SF M E+QQQ+A ++L+DPAVESL+SF+GV Sbjct: 552 ILYLLIPKGFFPLQDNGLIQGTLEAPQSVSFSNMAERQQQVAAIILKDPAVESLTSFVGV 611 Query: 603 DGTNATLNSGRMLINLKPHEARDVSASDVIRRLQPKLTQAVPGVTLYMQPVQDLTIEDSV 662 DGTNATLN+GR+ INLKP RD +I RLQ ++ VPG+ LY+QPVQDLTI+ + Sbjct: 612 DGTNATLNNGRLQINLKPLSERDDRIPQIITRLQESVS-GVPGIKLYLQPVQDLTIDTQL 670 Query: 663 SRTQYQFTLEDADPGTLSTWVPKLIARLQQVPQLADVATNLQDQGLQAYIQIDRNAASRL 722 SRTQYQFTL+ LSTWVPKL+ LQQ DV ++ QDQGL A++ +DR++ASRL Sbjct: 671 SRTQYQFTLQATSLEELSTWVPKLVNELQQKAPFQDVTSDWQDQGLVAFVNVDRDSASRL 730 Query: 723 GITTAAIDNALYNAFGQRLISTIYTQSNLYRVVMEVKPEFQRGPEALDSIFLVTSAGGKV 782 GIT AAIDNALYNAFGQRLISTIYTQSN YRVV+E + G A + I L G V Sbjct: 731 GITMAAIDNALYNAFGQRLISTIYTQSNQYRVVLEHDVQATPGLAAFNDIRLTGIDGKGV 790 Query: 783 PLSSIATVTERTAPLVVNHIGQFPAATVSFNLAKGASLGEAVKAIKAAEDEIGMPDSTIT 842 PLSSIAT+ ER PL +NH+ QFP+ATVSFNLA+G SLGEAV A+ AE EI +P T Sbjct: 791 PLSSIATIEERFGPLSINHLNQFPSATVSFNLAQGYSLGEAVAAVTLAEKEIQLPADITT 850 Query: 843 NFQGAALAFQASLSNTLWLILAAIITMYIVLGVLYESYIHPITILSTLPSAGVGALLSLM 902 FQG+ LAFQA+L +TLWLI+AAI+ MYIVLGVLYES+IHPITILSTLP+AGVGALL+LM Sbjct: 851 RFQGSTLAFQAALGSTLWLIIAAIVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALM 910 Query: 903 ISGTDLGIIGIIGIILLIGIVKKNAIMMIDFALEAERHQGKSPREAIYQACLLRFRPILM 962 ++G +L +I IIGIILLIGIVKKNAIMMIDFAL AER QG +P +AIYQACLLRFRPILM Sbjct: 911 LTGNELDVIAIIGIILLIGIVKKNAIMMIDFALAAERDQGMTPYDAIYQACLLRFRPILM 970 Query: 963 TTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLR 1022 TT+AAL GALPLML TGVG+ELRQPLG+ MVGGL+VSQVLTLFTTPVIYL FD L R R Sbjct: 971 TTLAALFGALPLMLSTGVGAELRQPLGVCMVGGLIVSQVLTLFTTPVIYLLFDKLARNTR 1030 Query: 1023 ARFGQRAPGHGGEDDDDSK 1041 + H ED D S+ Sbjct: 1031 GK-----NRHRDEDIDSSE 1044 >yegN [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1040 Score = 1380 bits (3571), Expect = 0.0, Method: Compositional matrix adjust. Identities = 713/1026 (69%), Positives = 859/1026 (83%), Gaps = 1/1026 (0%) Query: 3 PSRQFILRPVATSLLMLAILLVGIVAYRLLPLSALPEVDYPTIQVVTLYPGASPDVMTSS 62 PSR FI+RPVAT+LLM+AILL GI+ YR LP+SALPEVDYPTIQVVTLYPGASPDVMTS+ Sbjct: 12 PSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSA 71 Query: 63 VTAPLERQFGQMPGLKQMSSTSSGGASVITLQFNLDLSLDVAEQEVQAAINAGSNLLPSD 122 VTAPLERQFGQM GLKQMSS SSGGASVITLQF L L LDVAEQEVQAAINA +NLLPSD Sbjct: 72 VTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSD 131 Query: 123 LPMPPVYSKVNPADTPIITLAVTSKTIPLPKVQDLIDTRLAQKISQLSGVGLVSLSGGQR 182 LP PPVYSKVNPAD PI+TLAVTS +P+ +V+D+++TR+AQKISQ+SGVGLV+LSGGQR Sbjct: 132 LPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQR 191 Query: 183 PAVRMQLNPRAVAALGLNLDDVRTAIGNANVNQAKGSFDGPTRASTIDANDQLRSADEYR 242 PAVR++LN +A+AALGL + VRTAI ANVN AKGS DGP+RA T+ ANDQ++SA+EYR Sbjct: 192 PAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYR 251 Query: 243 NLIIAYKNGAPIRVSDVADVIDGAENVRLGAWANQQPAVIVNIQRQPGANVIAVVDSIKK 302 LIIAY+NGAPIR+ DVA V GAEN LGAWAN++ A+++N+QRQPGAN+I+ DSI++ Sbjct: 252 QLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQ 311 Query: 303 ILPQLQASLPGAIDVHILTDRTTTIRASVEDVKFELLLSVALVVMVIFVFLRNVPATIIP 362 +LPQL SLP ++ V +L+DRTT IRASV+D +FEL++++ALVVM+I++FLRN+PATIIP Sbjct: 312 MLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIP 371 Query: 363 SVAVPLSLVGTFAVMYLAGFSINNLTLMALTIATGFVVDDAIVMIENISRYIEEGMKPMQ 422 VAVPLSL+GTFAVM FSINNLTLMALTIATGFVVDDAIV+IENISRYIE+G KP+ Sbjct: 372 GVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLA 431 Query: 423 AALKGAEQIGFTIISLTFSLIAVLIPLLFMGDVVGRLFHEFAVTLAVSILISAVVSLTLT 482 AALKGA +IGFTIISLTFSLIAVLIPLLFMGD+VGRLF EFA+TLAV+ILISAVVSLTLT Sbjct: 432 AALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLT 491 Query: 483 PMMCARLLRHQPEEQQGWFYHKSQAFFDRIIARYGVMLEWVLERQKLTLLVAVATLGLTV 542 PMMCAR+L + +Q F S+ FDRIIA YG L VL LTL VA++TL L+V Sbjct: 492 PMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSV 551 Query: 543 LLYVFVPKGFFPLQDTGVIQGISEATQSISFGAMGEKQQQLAKVVLEDPAVESLSSFIGV 602 LL+VF+PKGFFP+QD G+IQG +A QS SF M ++Q+Q+A V+L+DPAV+SL+SF+GV Sbjct: 552 LLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV 611 Query: 603 DGTNATLNSGRMLINLKPHEARDVSASDVIRRLQPKLTQAVPGVTLYMQPVQDLTIEDSV 662 DGTN +LNS R+ INLKP + RD VI RLQ + + VPGV L++QP QDLTI+ V Sbjct: 612 DGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDK-VPGVDLFLQPTQDLTIDTQV 670 Query: 663 SRTQYQFTLEDADPGTLSTWVPKLIARLQQVPQLADVATNLQDQGLQAYIQIDRNAASRL 722 SRTQYQFTL+ LSTWVP+L+ +LQQ+PQL+DV+++ QD+GL AY+ +DR++ASRL Sbjct: 671 SRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRL 730 Query: 723 GITTAAIDNALYNAFGQRLISTIYTQSNLYRVVMEVKPEFQRGPEALDSIFLVTSAGGKV 782 GI+ A +DNALYNAFGQRLISTIYTQ+N YRVV+E E G ALD+I L +S GG V Sbjct: 731 GISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVV 790 Query: 783 PLSSIATVTERTAPLVVNHIGQFPAATVSFNLAKGASLGEAVKAIKAAEDEIGMPDSTIT 842 PLSSIA + +R APL +NH+ QFP T+SFN+ SLG+AV+AI E + +P T Sbjct: 791 PLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITT 850 Query: 843 NFQGAALAFQASLSNTLWLILAAIITMYIVLGVLYESYIHPITILSTLPSAGVGALLSLM 902 FQG+ LAFQ++L +T+WLI+AA++ MYIVLG+LYES+IHPITILSTLP+AGVGALL+L+ Sbjct: 851 QFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALL 910 Query: 903 ISGTDLGIIGIIGIILLIGIVKKNAIMMIDFALEAERHQGKSPREAIYQACLLRFRPILM 962 I+G++L +I IIGIILLIGIVKKNAIMMIDFAL AER QG SPREAIYQACLLRFRPILM Sbjct: 911 IAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILM 970 Query: 963 TTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLR 1022 TT+AALLGALPLML TGVG+ELR+PLGI MVGGL+VSQVLTLFTTPVIYL FD L + Sbjct: 971 TTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTK 1030 Query: 1023 ARFGQR 1028 +RF + Sbjct: 1031 SRFARH 1036 >ZyegN [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia coli O157:H7 EDL933 Length = 1040 Score = 1378 bits (3566), Expect = 0.0, Method: Compositional matrix adjust. Identities = 712/1026 (69%), Positives = 859/1026 (83%), Gaps = 1/1026 (0%) Query: 3 PSRQFILRPVATSLLMLAILLVGIVAYRLLPLSALPEVDYPTIQVVTLYPGASPDVMTSS 62 PSR FI+RPVAT+LLM+AILL GI+ YR LP+SALPEVDYPTIQVVTLYPGASPDVMTS+ Sbjct: 12 PSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSA 71 Query: 63 VTAPLERQFGQMPGLKQMSSTSSGGASVITLQFNLDLSLDVAEQEVQAAINAGSNLLPSD 122 VTAPLERQFGQM GLKQMSS SSGGASVITLQF L L LDVAEQEVQAAINA +NLLPSD Sbjct: 72 VTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSD 131 Query: 123 LPMPPVYSKVNPADTPIITLAVTSKTIPLPKVQDLIDTRLAQKISQLSGVGLVSLSGGQR 182 LP PPVYSKVNPAD PI+TLAVTS +P+ +V+D+++TR+AQKISQ+SGVGLV+LSGGQR Sbjct: 132 LPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQR 191 Query: 183 PAVRMQLNPRAVAALGLNLDDVRTAIGNANVNQAKGSFDGPTRASTIDANDQLRSADEYR 242 PAVR++LN +A+AALGL + VRTAI ANVN AKGS DGP+RA T+ ANDQ++SA+EYR Sbjct: 192 PAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYR 251 Query: 243 NLIIAYKNGAPIRVSDVADVIDGAENVRLGAWANQQPAVIVNIQRQPGANVIAVVDSIKK 302 LIIAY+NGAPIR+ DVA V GAEN LGAWAN++ A+++N+QRQPGAN+I+ DSI++ Sbjct: 252 QLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQ 311 Query: 303 ILPQLQASLPGAIDVHILTDRTTTIRASVEDVKFELLLSVALVVMVIFVFLRNVPATIIP 362 +LPQL SLP ++ V +L+DRTT IRASV+D +FEL++++ALVVM+I++FLRN+PATIIP Sbjct: 312 MLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIP 371 Query: 363 SVAVPLSLVGTFAVMYLAGFSINNLTLMALTIATGFVVDDAIVMIENISRYIEEGMKPMQ 422 VAVPLSL+GTFAVM FSINNLTLMALTIATGFVVDDAIV+IENISRYIE+G KP+ Sbjct: 372 GVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLA 431 Query: 423 AALKGAEQIGFTIISLTFSLIAVLIPLLFMGDVVGRLFHEFAVTLAVSILISAVVSLTLT 482 AALKGA +IGFTIISLTFSLIAVLIPLLFMGD+VGRLF EFA+TLAV+ILISAVVSLTLT Sbjct: 432 AALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLT 491 Query: 483 PMMCARLLRHQPEEQQGWFYHKSQAFFDRIIARYGVMLEWVLERQKLTLLVAVATLGLTV 542 PMMCAR+L + +Q F S+ FDRIIA YG L VL LTL VA++TL L+V Sbjct: 492 PMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSV 551 Query: 543 LLYVFVPKGFFPLQDTGVIQGISEATQSISFGAMGEKQQQLAKVVLEDPAVESLSSFIGV 602 LL+VF+PKGFFP+QD G+IQG +A QS SF M ++Q+Q+A V+L+DPAV+SL+SF+GV Sbjct: 552 LLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV 611 Query: 603 DGTNATLNSGRMLINLKPHEARDVSASDVIRRLQPKLTQAVPGVTLYMQPVQDLTIEDSV 662 DGTN +LNS R+ INLKP + RD VI RLQ + + VPGV L++QP QDLTI+ V Sbjct: 612 DGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDK-VPGVDLFLQPTQDLTIDTQV 670 Query: 663 SRTQYQFTLEDADPGTLSTWVPKLIARLQQVPQLADVATNLQDQGLQAYIQIDRNAASRL 722 SRTQYQFTL+ LSTWVP+L+ +LQQ+PQ++DV+++ QD+GL AY+ +DR++ASRL Sbjct: 671 SRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQISDVSSDWQDKGLVAYVNVDRDSASRL 730 Query: 723 GITTAAIDNALYNAFGQRLISTIYTQSNLYRVVMEVKPEFQRGPEALDSIFLVTSAGGKV 782 GI+ A +DNALYNAFGQRLISTIYTQ+N YRVV+E E G ALD+I L +S GG V Sbjct: 731 GISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVV 790 Query: 783 PLSSIATVTERTAPLVVNHIGQFPAATVSFNLAKGASLGEAVKAIKAAEDEIGMPDSTIT 842 PLSSIA + +R APL +NH+ QFP T+SFN+ SLG+AV+AI E + +P T Sbjct: 791 PLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITT 850 Query: 843 NFQGAALAFQASLSNTLWLILAAIITMYIVLGVLYESYIHPITILSTLPSAGVGALLSLM 902 FQG+ LAFQ++L +T+WLI+AA++ MYIVLG+LYES+IHPITILSTLP+AGVGALL+LM Sbjct: 851 QFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALM 910 Query: 903 ISGTDLGIIGIIGIILLIGIVKKNAIMMIDFALEAERHQGKSPREAIYQACLLRFRPILM 962 I+G++L +I IIGIILLIGIVKKNAIMMIDFAL AER QG SPR+AIYQACLLRFRPILM Sbjct: 911 IAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILM 970 Query: 963 TTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLGFDSLGRRLR 1022 TT+AALLGALPLML TGVG+ELR+PLGI MVGGL+VSQVLTLFTTPVIYL FD L + Sbjct: 971 TTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTK 1030 Query: 1023 ARFGQR 1028 +RF + Sbjct: 1031 SRFARH 1036