BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0057.p (264 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PAB0317 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryl... 122 1e-27 BH1416 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryla... 120 4e-27 PH1697 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryla... 117 2e-26 aq_718_1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphory... 115 7e-26 TVN0081 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphoryl... 112 7e-25 >PAB0317 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Pab Pyrococcus abyssi Length = 361 Score = 122 bits (305), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 82/239 (34%), Positives = 121/239 (50%), Gaps = 12/239 (5%) Query: 1 MRALLLAAGLGTRLRPLTDLLPKCLVPINGRPLLDYWIENLLGQGVDDILINT-YYQAHL 59 M+A+LLA G+GTRL PLT PK ++P +PL++Y + NL+ GVD+I++ Y + + Sbjct: 1 MQAVLLAGGMGTRLLPLTIYRPKPMIPFFNKPLMEYMVNNLVEVGVDEIIVLVGYLKEKI 60 Query: 60 VERYIAASCWRDRVTLVS-EPVLLGTAGTALANRAFFGNKPFLLAHADNLTRFDCRDFLA 118 +E + + + + E V GTAG AL F F++A +D LT D + L Sbjct: 61 IEHFGDGKEFGVEIKYSNGENVKFGTAG-ALKRAEKFIEGTFIVASSDVLTNLDFKSLLE 119 Query: 119 AHRDRPAHTALTMMLFETPDPRSCGIVELDANGVVQAFHEK--VPEPPGRLANAAVYLLE 176 H + TM L + DP G+ LD G + F EK E P L NA +Y+ E Sbjct: 120 FHAKKGGIA--TMALTKVEDPSPYGVAVLDDEGKILYFKEKPRREEAPSNLVNAGIYVFE 177 Query: 177 PEVLDFLDSLGRPEIDFSTEVIPHYLGR---IATFTNHAYHRDIGTVQSWTQAQQDFHM 232 PE+LD + G+P DFS + P L I F Y D+G ++ QA +D + Sbjct: 178 PEILDLIPK-GKP-FDFSLNLFPKMLEEGIPIYGFPFDEYWNDVGRPSTYLQATEDVFL 234 >BH1416 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Bha Bacillus halodurans Length = 249 Score = 120 bits (300), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 75/237 (31%), Positives = 126/237 (53%), Gaps = 11/237 (4%) Query: 1 MRALLLAAGLGTRLRPLTDLLPKCLVPINGRPLLDYWIENLLGQGVDDILINTYYQAHLV 60 M+ ++LA G GTRL+PLTD +PK ++PI G P L + + +L G+ DI++ +Y H + Sbjct: 1 MKGVILAGGRGTRLKPLTDQIPKPMLPIAGVPCLAHGLAHLAAHGIRDIVMLVHYLNHQM 60 Query: 61 ERYIA-ASCWRDRVTLVSEPVLLGTAGTALANRAFFGNKPFLLAHADNLTRFDCRDFLAA 119 + Y S + R+T V E LGTAG+ A + ++PF++ D LT ++ + Sbjct: 61 KAYFQDGSKYGMRITYVQEDAPLGTAGSLKAAERYL-DEPFVVMSGDVLTTISIQEAIVF 119 Query: 120 HRDRPAHTALTMMLFETPDPRSCGIVELDANGVVQAFHEKVPEPPGR--LANAAVYLLEP 177 H+ + ++ +TM+ + ++ G+V+ N V AF EK E R L N +Y+++P Sbjct: 120 HKRQ--NSLMTMLTKRVKNGQNYGVVQTGPNHRVVAFREKPTEDKTREVLVNTGLYVMDP 177 Query: 178 EVLDFLDSLGRPEIDFSTEVIPHYLGR---IATFTNHAYHRDIGTVQSWTQAQQDFH 231 VL ++ +D +VIP+ + R I Y RDIG+ + QA D + Sbjct: 178 FVLSYIPK--GSAVDLGKDVIPYLVDRKLDIFALEGGGYWRDIGSFHDYLQANNDVN 232 >PH1697 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Pho Pyrococcus horikoshii Length = 361 Score = 117 bits (294), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 80/239 (33%), Positives = 123/239 (51%), Gaps = 12/239 (5%) Query: 1 MRALLLAAGLGTRLRPLTDLLPKCLVPINGRPLLDYWIENLLGQGVDDILINT-YYQAHL 59 M+A+LLA G GTRL PLT PK ++P +PL++Y + NL+G GV++I++ Y + + Sbjct: 1 MQAVLLAGGKGTRLLPLTVYRPKPMIPFFNKPLMEYMLMNLIGIGVEEIIVLVGYLKEKI 60 Query: 60 VERYIAASCWRDRVTLVS-EPVLLGTAGTALANRAFFGNKPFLLAHADNLTRFDCRDFLA 118 +E + + + + E + LGTAG AL F + F++A +D LT F+ Sbjct: 61 IEYFGRGDKFGVEIKYSNGENIKLGTAG-ALKKAEKFIDDTFIVASSDVLTNLSFDSFIR 119 Query: 119 AHRDRPAHTALTMMLFETPDPRSCGIVELDANGVVQAFHE--KVPEPPGRLANAAVYLLE 176 HR++ TM L + DP G+ LD + F E K E P L NA +Y+ E Sbjct: 120 FHREKGGIA--TMALTKVEDPTPYGVAVLDNENRILYFKEKPKREEAPSNLVNAGIYIFE 177 Query: 177 PEVLDFLDSLGRPEIDFSTEVIPHYLGR---IATFTNHAYHRDIGTVQSWTQAQQDFHM 232 PE+LD + G+ DFS ++ P L I F Y D+G ++ QA +D + Sbjct: 178 PEILDLIPR-GKA-FDFSLDLFPKMLEEGIPIYGFPFDEYWNDVGRPSTYLQATEDVFL 234 >aq_718_1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Aae Aquifex aeolicus Length = 384 Score = 115 bits (289), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 124/239 (51%), Gaps = 17/239 (7%) Query: 1 MRALLLAAGLGTRLRPLTDLLPKCLVPINGRPLLDYWIENLLGQGVDDILINTYYQAHLV 60 M+ ++LA G GTR++PLT+ +PK ++P+ RP++++ + L G+++I++ YYQA ++ Sbjct: 1 MKGVILAGGFGTRIQPLTNSIPKPMLPVANRPIMEHVVHRLKEAGIEEIVVLLYYQAEVI 60 Query: 61 ERYIA-ASCWRDRVTLVSEPVLLGTAGTALANRAFFGNKPFLLAHADNLTRFDCRDFLAA 119 + Y S + ++T V GTAG + + N+ F++ D +T F+ + +A Sbjct: 61 KNYFKDGSDFGVKITYVQPEADYGTAGAVKQAQNYL-NETFIIVSGDVITDFNLSELIAF 119 Query: 120 HRDRPAHTALTMMLFETPDPRSCGIVELDANGVVQAFHEK--VPEPPGRLANAAVYLLEP 177 H+ + + T+ L+ +P G+V + G V F EK E N +Y++EP Sbjct: 120 HKSKSSK--FTLALYSVENPLQFGVVITNKEGKVLKFLEKPGWGEVFSDTVNTGIYVVEP 177 Query: 178 EVLDFLDSLGRPE---IDFSTEVIPHYLGR---IATFTNHAYHRDIGTVQSWTQAQQDF 230 E+L+++ PE DF+ ++ P + + Y RDIG + S+ +D Sbjct: 178 EILNYI-----PEDKPFDFAMDLFPKLMKSGIDLWALKMRGYWRDIGNIDSYRDVHKDI 231 >TVN0081 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Tvo Thermoplasma volcanium Length = 359 Score = 112 bits (281), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 73/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%) Query: 1 MRALLLAAGLGTRLRPLTDLLPKCLVPINGRPLLDYWIENLLGQGVDDILINTYYQAHLV 60 ++ +L+A G GTRLRP+T +PK LVP+ G+P++ Y +++ GV DI+I T Y+ + Sbjct: 3 VKGVLMAGGKGTRLRPITYSIPKPLVPVAGKPVISYILDSFYNAGVKDIIITTGYKFEAL 62 Query: 61 ERYIAASCWRDRVTLVS-EPVLLGTAGTALANRAFFGNKPFLLAHADNLTRFDCRDFLAA 119 + + + + D+ L S E GTAG F + F++ D L FD + Sbjct: 63 IKGVLENKFSDQNILFSVEKDPAGTAGGVKLAENFI-DDTFVVGSGDILIDFDVSKMIEE 121 Query: 120 HRDRPAHTALTMMLFETPDPRSCGIVELDANGVVQAFHE--KVPEPPGRLANAAVYLLEP 177 H+ R A+ +T+ L DP GI E+D G V+ F E K E NA VY++EP Sbjct: 122 HKKRGAN--ITIALTRVDDPSQFGIAEVDDEGYVKRFLEKPKKSETFSNTINAGVYVIEP 179 Query: 178 EVLDFLDSLGRPEIDFSTEVIPHYLG---RIATFTNHAYHRDIGTVQSWTQAQQ 228 VL+++ + DF+ ++ P + +I T+ + D G +A Q Sbjct: 180 SVLEYIPK--GVQFDFAKDLFPKAMANGIKIYTYEINGVWLDAGRPGDLIKANQ 231