BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0011.p (1247 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1398 0.0 VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1161 0.0 PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1146 0.0 ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1141 0.0 ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1141 0.0 >RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding domain Rso Ralstonia solanacearum Length = 905 Score = 1398 bits (3619), Expect = 0.0, Method: Compositional matrix adjust. Identities = 683/903 (75%), Positives = 772/903 (85%), Gaps = 4/903 (0%) Query: 348 HEMRLSGLEPFTINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQI 407 H MRLSGLEPF I + +L+VNVGERTNVTGSKAFAR+ILN Q+DEALAVARQQVENGAQ+ Sbjct: 4 HLMRLSGLEPFNIGEDTLFVNVGERTNVTGSKAFARMILNSQFDEALAVARQQVENGAQV 63 Query: 408 IDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSI 467 IDINMDEAMLDS AAM RFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGK+IVNSI Sbjct: 64 IDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSI 123 Query: 468 SMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPE 527 S+KEGEE+F AKL +RYGAA +VMAFDE GQADTFARK EIC+R+Y LV+++ F PE Sbjct: 124 SLKEGEEQFAHHAKLIKRYGAAAVVMAFDEQGQADTFARKTEICKRSYDFLVNQVGFAPE 183 Query: 528 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPARE 587 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWI Q LP+AK+SGGVSNVSFSFRGND RE Sbjct: 184 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQKLPHAKVSGGVSNVSFSFRGNDVVRE 243 Query: 588 AIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAAT 647 AIHTVFLYHAI AGM MGIVNAG +GVY++L ELRERVEDVVLNRR DAT+R++E A Sbjct: 244 AIHTVFLYHAIGAGMDMGIVNAGQLGVYENLAPELRERVEDVVLNRRPDATDRLLEIADR 303 Query: 648 LKAGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQVAADGGRPIHVIEGP 707 K G K E L WR PV KRL+HALVHGIT ++VEDTEEVRQ++ A GGRPI VIEGP Sbjct: 304 YKGGGAKREENLAWRQEPVEKRLAHALVHGITDYVVEDTEEVRQKIFAAGGRPIQVIEGP 363 Query: 708 LMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVAKPKGK 767 LMDGMN+VGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ+ A G+V + +GK Sbjct: 364 LMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQIAAAGGDV-RSRGK 422 Query: 768 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLIT 827 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPC EILAKAK E ADIIGLSGLIT Sbjct: 423 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGLIT 482 Query: 828 PSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAV 887 PSLEEMAYVA EMQRD YF K+PL+IGGATTSR HTAVKIAPNYEGPVVYVPDASR+V Sbjct: 483 PSLEEMAYVASEMQRDEYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSV 542 Query: 888 SVAQSLLADEQKTQYVADLNADYERIREQHASKKAAPMLPLAAARANKTKLE---FAPVK 944 SVA SLL+DE +Y+ +L+ADY+RIR QHASKKA PM+ LAAARANKT+++ + P K Sbjct: 543 SVASSLLSDEAAARYIEELHADYDRIRTQHASKKAMPMVSLAAARANKTRIDWSNYTPPK 602 Query: 945 PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVFQEAQAML 1004 PKF+GRR+F+N DL LA YIDWGPFFQTWDLAG +P IL D +VGE+A +VF + ++ML Sbjct: 603 PKFVGRRVFRNYDLNELAQYIDWGPFFQTWDLAGKFPDILNDAIVGESARRVFSDGKSML 662 Query: 1005 KKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVAR 1064 ++I GRWLTANGVI+LLPANTVNDDDIEIYTD++RS+VA T+ +RQQ+E+P++DGV R Sbjct: 663 ARLIAGRWLTANGVIALLPANTVNDDDIEIYTDETRSEVALTWRNIRQQSERPIIDGVMR 722 Query: 1065 PNQCLSDFIAPKASGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEA 1124 PN+CL+DFIAPK +G+ DYIG+FAVT G+GI+K E FE HDDYS+IMLKALADR AEA Sbjct: 723 PNRCLADFIAPKDTGIADYIGLFAVTGGIGIDKREAAFEADHDDYSAIMLKALADRFAEA 782 Query: 1125 FAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTVKAEAFRVMQCD 1184 FAE LH RVR+DLWGYA DE L + LI+E+Y GIRPAPGYPACPEHTVK + FRV+ Sbjct: 783 FAECLHARVRRDLWGYAQDETLDNDALIREEYRGIRPAPGYPACPEHTVKRDLFRVLDAQ 842 Query: 1185 EIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERRHVPKEEVERWLA 1244 EIGM LTE+ AM P ASVSGF +HP S YF +GKIG+DQV DMA R + VER LA Sbjct: 843 EIGMNLTEALAMTPAASVSGFQLSHPDSTYFTIGKIGQDQVDDMAARSGEDRRNVERALA 902 Query: 1245 PNL 1247 PNL Sbjct: 903 PNL 905 >VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Vch Vibrio cholerae Length = 899 Score = 1161 bits (3003), Expect = 0.0, Method: Compositional matrix adjust. Identities = 583/919 (63%), Positives = 708/919 (77%), Gaps = 32/919 (3%) Query: 338 IAPRKLPEPTHEMRLSGLEPFTINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR LP+ E RLSGLEP I ++L+VNVGERTNVTGS F RLI EQYDEAL VA Sbjct: 2 VKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 R+QVENGAQIIDINMDE MLD+ A M RFLNL ASEP+I++VP+M+DSSKWEVIEAGLKC Sbjct: 62 REQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSIS+KEG+EKF+ +AKL RRYGAAVIVMAFDEVGQADT RK+EIC RAY + Sbjct: 122 IQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAFDEVGQADTRERKLEICRRAYHI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 LVD++ FPPEDIIFDPNIFAVATGI+EHNNYA+DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGN+ REAIH VFLYH K GM MGIVNAG + +YD++P +LRE VEDV+LNRR D Sbjct: 242 SFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDG 301 Query: 638 TERMIEYAATLK---AGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQVA 694 TER++E A + G +++ + LEWR PVAKRL HALV GIT++IV+DTEE RQQ + Sbjct: 302 TERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQAS 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 +P+ VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFI +K Sbjct: 362 ----KPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFINAQK--- 414 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 +G + GKI++ATVKGDVHDIGKNIV VVLQCNNFE++++GVMVPC +IL A+E Sbjct: 415 ---SGSTS--NGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVARE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 + DIIGLSGLITPSL+EM +VAKEM+R G ++PL+IGGATTS+AHTAVKI NY Sbjct: 470 QNVDIIGLSGLITPSLDEMVHVAKEMERQ----GFELPLLIGGATTSKAHTAVKIEQNYH 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVADLNADYERIREQHASK--KAAPMLPLAAAR 932 PVVYV +ASRAV V SLL+DEQ+ ++ L+ DYER R+QHA K K+ P + L AR Sbjct: 526 APVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRP-VTLEQAR 584 Query: 933 ANKTKLEFA---PVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVV 989 ANK L++A P P G +F+N+ L L YIDW PFF TW L G YPAIL E V Sbjct: 585 ANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAILEHEEV 644 Query: 990 GEAATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYG 1049 GE A ++F +A A+L K+ L A+G+ +L PA +V DDIE+Y+D+SR+QVA Y Sbjct: 645 GEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVG-DDIEVYSDESRTQVAHVLYN 703 Query: 1050 LRQQTEKPVVDGVARPNQCLSDFIAPKASGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDY 1109 LRQQTEKP N CLSD++APK SG +D+IG FAVT G+G ++ DDY Sbjct: 704 LRQQTEKP-----KGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDY 758 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACP 1169 ++IM++A+ADRLAEAFAEYLHE+VRK++WGYA+DENLS+ DLI+E+Y GIRPAPGYPACP Sbjct: 759 NAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACP 818 Query: 1170 EHTVKAEAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDM 1228 EHT KA ++++ +E IGM LT SYAM+PGASVSG+YF+HP S+YF V +I DQ+ Sbjct: 819 EHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSY 878 Query: 1229 AERRHVPKEEVERWLAPNL 1247 AER+ EE E+WLAPNL Sbjct: 879 AERKGWRLEEAEKWLAPNL 897 >PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Pae Pseudomonas aeruginosa Length = 898 Score = 1146 bits (2965), Expect = 0.0, Method: Compositional matrix adjust. Identities = 593/915 (64%), Positives = 689/915 (75%), Gaps = 28/915 (3%) Query: 340 PRKLPEPTHEMRLSGLEPFTINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQ 399 PR +PE RLSGLEPFTI+ SL+VNVGERTN+TGS FARLI E Y EAL VA+Q Sbjct: 1 PRAIPEIPRACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIREENYAEALEVAQQ 60 Query: 400 QVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQ 459 QVE GAQ+IDINMDE MLDS AAM FLNLIASEPDI+RVPIMIDSSKWEVIEAGLKC+Q Sbjct: 61 QVEAGAQVIDINMDEGMLDSKAAMVTFLNLIASEPDISRVPIMIDSSKWEVIEAGLKCIQ 120 Query: 460 GKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLV 519 GK IVNSISMKEG E F A+LC+RYGAAV+VMAFDE GQADT ARK EIC+R+Y +LV Sbjct: 121 GKGIVNSISMKEGVEAFKHHARLCKRYGAAVVVMAFDEDGQADTQARKEEICKRSYDILV 180 Query: 520 DKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSF 579 D++ FPPEDIIFD NIFA+ATGIEEHNNYAVDFI A +I NLPYA SGGVSNVSFSF Sbjct: 181 DEVGFPPEDIIFDANIFAIATGIEEHNNYAVDFINACAYIRDNLPYALSSGGVSNVSFSF 240 Query: 580 RGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATE 639 RGN+P REAIH+VFLY+AI+ G+TMGIVNAG + +YD++P LR+RVEDVVLNR +ATE Sbjct: 241 RGNNPVREAIHSVFLYYAIRNGLTMGIVNAGQLEIYDEIPKALRDRVEDVVLNRTPEATE 300 Query: 640 RMIEYAATLKAGDK-KEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQVAADGG 698 ++ A K G KE EWR+ V KRL HALV GIT WIVEDTEE RQQ A Sbjct: 301 ALLAIADDYKGGGAVKEAEDEEWRSYSVEKRLEHALVKGITTWIVEDTEECRQQCA---- 356 Query: 699 RPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIAT 758 RPI VIEGPLM GMNVVGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIE EK Sbjct: 357 RPIEVIEGPLMSGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEAEK------- 409 Query: 759 GEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKAD 818 G+ + KGKI++ATVKGDVHDIGKNIV VVL CN ++VV++GVMVP +IL A EK D Sbjct: 410 GDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCD 469 Query: 819 IIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEG-PV 877 IIGLSGLITPSL+EM +VAKEMQR + ++PLMIGGATTS+AHTAVKI P Y V Sbjct: 470 IIGLSGLITPSLDEMVHVAKEMQRQNF----QLPLMIGGATTSKAHTAVKIDPQYSNDAV 525 Query: 878 VYVPDASRAVSVAQSLLADEQKTQYVADLNADYERIREQHASKKA-APMLPLAAARANKT 936 VYV DASRAV VA SLL+ E K YVA ADY +RE+ A++ A L A ANK Sbjct: 526 VYVTDASRAVGVATSLLSKELKADYVARTRADYAVVRERTANRSARTERLSYEQAIANKP 585 Query: 937 KLEFAPVK---PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAA 993 ++A + P F G R+ +DL +LA YIDW PFF +WDLAG YP ILTDEVVGEAA Sbjct: 586 AFDWAGYQAPTPSFTGVRVLDEIDLAVLAEYIDWTPFFISWDLAGKYPRILTDEVVGEAA 645 Query: 994 TKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLRQQ 1053 T +F +AQAMLKK+ID + + A V PAN V DD+E+Y D + T + LRQQ Sbjct: 646 TSLFNDAQAMLKKLIDEKLIKARAVFGFWPANQVEHDDLEVYGADGETLA--TLHHLRQQ 703 Query: 1054 TEKPVVDGVARPNQCLSDFIAPKASGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIM 1113 T KP DG +PN L+DF+APK SGV+DYIG F TAG+G E+ K +E DDY+SIM Sbjct: 704 TIKP--DG--KPNLSLADFVAPKESGVRDYIGGFITTAGIGAEEVAKAYEAKGDDYNSIM 759 Query: 1114 LKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEHTV 1173 +KALADRLAEA AE+LHERVRK+ WGYA DE+L + LIKE+Y+GIRPAPGYPACP+HT Sbjct: 760 VKALADRLAEACAEWLHERVRKEYWGYARDEHLDNEALIKEQYVGIRPAPGYPACPDHTE 819 Query: 1174 KAEAFRVMQCDEI-GMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAERR 1232 K F ++ + G+ LTE YAMFP A+VSG+YFAHPQ++YF VGKI +DQV ++R+ Sbjct: 820 KGTLFELLDPQGLSGVSLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVERYSQRK 879 Query: 1233 HVPKEEVERWLAPNL 1247 ERWLAPNL Sbjct: 880 GQEASVSERWLAPNL 894 >ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ecs Escherichia coli O157:H7 Length = 901 Score = 1141 bits (2952), Expect = 0.0, Method: Compositional matrix adjust. Identities = 587/917 (64%), Positives = 682/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKLPEPTHEMRLSGLEPFTINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRKLPE RLSGLEP I D SL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQVA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVADLNADYERIREQHASKKA-APMLPLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QH KK P + L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLEFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N ++ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLR 1051 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKASGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENLS+ +LI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKAEAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAE 1230 T KA + +++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEEVERWLAPNL 1247 R+ + +VERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 901 Score = 1141 bits (2952), Expect = 0.0, Method: Compositional matrix adjust. Identities = 587/917 (64%), Positives = 682/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKLPEPTHEMRLSGLEPFTINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRKLPE RLSGLEP I D SL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQVA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVAKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVADLNADYERIREQHASKKA-APMLPLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +YE +R QH KK P + L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLEFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N ++ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVFQEAQAMLKKIIDGRWLTANGVISLLPANTVNDDDIEIYTDDSRSQVAFTYYGLR 1051 A ++F++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKASGVQDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLSSTDLIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENLS+ +LI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKAEAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVVDMAE 1230 T KA + +++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEEVERWLAPNL 1247 R+ + +VERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896