BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0083.p (183 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1784 [F] COG0125 Thymidylate kinase Rso Ralstonia solanacearum 218 4e-57 PA2962 [F] COG0125 Thymidylate kinase Pae Pseudomonas aeruginosa 164 1e-40 NMB0670 [F] COG0125 Thymidylate kinase Nme Neisseria meningitidi... 160 1e-39 NMA0869 [F] COG0125 Thymidylate kinase NmA Neisseria meningitidi... 156 3e-38 SP0935 [F] COG0125 Thymidylate kinase Spn Streptococcus pneumoni... 130 2e-30 >RSc1784 [F] COG0125 Thymidylate kinase Rso Ralstonia solanacearum Length = 205 Score = 218 bits (556), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 121/204 (59%), Positives = 144/204 (70%), Gaps = 23/204 (11%) Query: 3 SGKFITFEGIDGAGKSTHIPFVTQLLRER----GMTVVATREPGGTDLGERLRELVLHHK 58 +GKFITFEGIDGAGKSTH+ + Q L R G VV TREPGGT LGERLRE++LH + Sbjct: 2 TGKFITFEGIDGAGKSTHLAWFAQQLEARLAPQGRKVVVTREPGGTPLGERLREVLLHER 61 Query: 59 MHLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLE 118 MHLETEALLMFASRREH+A+VI+PAL RGDWVISDRFTDATFAYQGGGR LA+++L+ LE Sbjct: 62 MHLETEALLMFASRREHIAEVIQPALERGDWVISDRFTDATFAYQGGGRGLAIERLEALE 121 Query: 119 QWVHPHLQPDLTLLFDVPLEVARARLDIYRPPPC----AAQF---------------PQR 159 QWV LQP TLLFD+ EVA ARL R P +AQF P R Sbjct: 122 QWVQQGLQPTRTLLFDLAPEVAAARLADARTPDKFEAESAQFFVRTRAEYLRRAAAEPGR 181 Query: 160 FRLIDSTRPIPVIQEELRAIVAAL 183 F +ID+ R I+++L ++A+L Sbjct: 182 FVVIDAARARDDIRKDLEKLLASL 205 >PA2962 [F] COG0125 Thymidylate kinase Pae Pseudomonas aeruginosa Length = 210 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 22/196 (11%) Query: 3 SGKFITFEGIDGAGKSTHIPFVTQLLRERGMTVVATREPGGTDLGERLRELVL---HHKM 59 +G F+T EG +GAGKST+ ++ + LRERG+ V TREPGGT L ER+REL+L M Sbjct: 2 TGLFVTLEGPEGAGKSTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLAPSDEPM 61 Query: 60 HLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQ 119 +TE LLMFA+R +HLA VI PALARG V+ DRFTDAT+AYQGGGR L ++ LE Sbjct: 62 AADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQGGGRGLPEARIAALES 121 Query: 120 WVHPHLQPDLTLLFDVPLEV------ARARLDIYRPP-------------PCAAQFPQRF 160 +V L+PDLTL+FD+P+E+ AR RLD + AAQ P+R+ Sbjct: 122 FVQGDLRPDLTLVFDLPVEIGLARAAARGRLDRFEQEDRRFFEAVRQTYLQRAAQAPERY 181 Query: 161 RLIDSTRPIPVIQEEL 176 +++D+ P+ +Q L Sbjct: 182 QVLDAGLPLAEVQAGL 197 >NMB0670 [F] COG0125 Thymidylate kinase Nme Neisseria meningitidis MC58 Length = 206 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 88/197 (44%), Positives = 122/197 (61%), Gaps = 21/197 (10%) Query: 5 KFITFEGIDGAGKSTHIPFVTQLLRERGMTVVATREPGGTDLGERLRELVLH--HKMHLE 62 +FIT +GIDGAGKST++ + RG+ V+ TREPGGT +GE LRE++L+ K L Sbjct: 4 QFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKAGLR 63 Query: 63 TEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQWVH 122 E L+MFA+R +H+ +VI PAL+ G V+SDRFTDATFAYQGGGR + + ++ LE WV Sbjct: 64 AETLMMFAARMQHIEEVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIEILEHWVQ 123 Query: 123 PHLQPDLTLLFDVPLEVARARLDIYRPP-------------------PCAAQFPQRFRLI 163 L+PDLTLL DVPLEV+ AR+ R AA P+R+ +I Sbjct: 124 GGLKPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRGVYLDRAAACPERYAVI 183 Query: 164 DSTRPIPVIQEELRAIV 180 DS R + ++ + ++ Sbjct: 184 DSNRNLDEVRNSIEKVL 200 >NMA0869 [F] COG0125 Thymidylate kinase NmA Neisseria meningitidis Z2491 Length = 206 Score = 156 bits (394), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 87/197 (44%), Positives = 120/197 (60%), Gaps = 21/197 (10%) Query: 5 KFITFEGIDGAGKSTHIPFVTQLLRERGMTVVATREPGGTDLGERLRELVLH--HKMHLE 62 +FIT +GIDGAGKST++ + RG+ V+ TREPGGT +GE LRE++L+ K L Sbjct: 4 QFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKAGLR 63 Query: 63 TEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRLEQWVH 122 E L+MFA+R +H+ VI PAL+ G V+SDRFTDATFAYQGGGR + + ++ LE WV Sbjct: 64 AETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIEILEHWVQ 123 Query: 123 PHLQPDLTLLFDVPLEVARARLDIYRPP-------------------PCAAQFPQRFRLI 163 L+PDLTLL DVPLEV+ AR+ R AA P+R+ +I Sbjct: 124 GGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAACPERYAVI 183 Query: 164 DSTRPIPVIQEELRAIV 180 DS + ++ + ++ Sbjct: 184 DSNLGLDEVRNSIEKVL 200 >SP0935 [F] COG0125 Thymidylate kinase Spn Streptococcus pneumoniae TIGR4 Length = 212 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 66/147 (44%), Positives = 98/147 (66%), Gaps = 3/147 (2%) Query: 1 MASGKFITFEGIDGAGKSTHIPFVTQLLRERGMTVVATREPGGTDLGERLRELVL---HH 57 M+ G ++ EG +GAGK++ + + +L E+G+ V+ TREPGG +GE++RE++L H Sbjct: 1 MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHT 60 Query: 58 KMHLETEALLMFASRREHLAQVIEPALARGDWVISDRFTDATFAYQGGGRKLALDKLDRL 117 +M +TE LL ASRR+HL + + PAL G VI DRF D++ AYQG GR L ++ +D L Sbjct: 61 QMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWL 120 Query: 118 EQWVHPHLQPDLTLLFDVPLEVARARL 144 Q+ L+PDLTL FD+ +E AR+ Sbjct: 121 NQFATDGLKPDLTLYFDIEVEEGLARI 147