BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0028.0345.p (464 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO3526 [R] COG1253 Hemolysins and related proteins containing C... 494 e-139 ytfL [R] COG1253 Hemolysins and related proteins containing CBS ... 478 e-134 ZytfL [R] COG1253 Hemolysins and related proteins containing CBS... 478 e-134 ECs5196 [R] COG1253 Hemolysins and related proteins containing C... 478 e-134 STM4407 [R] COG1253 Hemolysins and related proteins containing C... 476 e-134 >YPO3526 [R] COG1253 Hemolysins and related proteins containing CBS domains Ype Yersinia pestis Length = 443 Score = 494 bits (1271), Expect = e-139, Method: Compositional matrix adjust. Identities = 244/425 (57%), Positives = 313/425 (73%), Gaps = 1/425 (0%) Query: 6 IFTSLLLILLLVVVSAFLSCAEISIAASRKIRLEMMSKEGVHNADRVLSLQAQPGNFFTV 65 + S+LLIL L+ VSAF S +EIS+AASRKI+L++++ EG NA RVL LQ PG FFTV Sbjct: 1 MLNSILLILFLIAVSAFFSLSEISLAASRKIKLKLLADEGDTNALRVLKLQETPGMFFTV 60 Query: 66 VQIGLNAVAILGGVVGEPALTPHMREIVSTFYVGPLLENISFAMSFLVVTAFFILFADLM 125 VQIGLNAVAILGG+VG+ A +P + + F L + SF SF++VT+ FILFADL Sbjct: 61 VQIGLNAVAILGGIVGDAAFSPSFKLVFERFMAPELADQASFVCSFVLVTSLFILFADLT 120 Query: 126 PKRLAMAAPERAAVALVQPMLLLETLFRPLVWFFNSLSKWIFTLFGLPQVRQDVITPSEI 185 PKR+ M +PE AV +V PM +FRPLVWFFN ++ IF LF LP VR D IT +I Sbjct: 121 PKRIGMISPEAVAVRIVNPMRFCLMIFRPLVWFFNGMANLIFRLFKLPMVRNDDITSDDI 180 Query: 186 HAMVDAGAQAGVLLTQEHHLIENVFELESRYVPSAMTPRDSIVYFLLTDSEDMIRQKIID 245 +A+V+AGA AGVL QEH LIENVFELESR VPS+MT R++++YF L +SED I+ KI Sbjct: 181 YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTSRENVIYFDLRESEDSIKDKIST 240 Query: 246 HPHSRFLVCDGHIDAVLGYIDSKDVLKRLLKGEQFSLADKGLVHTPLSIPDSLNLWEVLE 305 HPHS+FLVCDGHID V+GY+DSKD+L R+L + L+ + + L +PD+L L E LE Sbjct: 241 HPHSKFLVCDGHIDQVVGYVDSKDLLNRVLGNQSLVLSSGVQIRSALIVPDTLTLSEALE 300 Query: 306 RMKAMDEDLAIVVNEYALVVGIISITDVTGVLMGNLLAITEEEQQIVRRDENSWLMDGLT 365 K ED A+++NEYALVVGII++ DV LMG+L+ +EE QIV RDENSWL++G T Sbjct: 301 SFKTAGEDFAVILNEYALVVGIITLNDVMTTLMGDLVGQGQEE-QIVARDENSWLIEGGT 359 Query: 366 PLNDVMNELDIDEYPNPVGYETLSGFIMYMLRKIPKKTDFVLFSDFKFEVVDIEGNRINQ 425 P+ DVM L ID++P YET+ GF+MYMLRKIPK+TDFV ++ +KFEVVDI+ +I+Q Sbjct: 360 PIEDVMRVLHIDDFPQSGNYETIGGFMMYMLRKIPKRTDFVKYAGYKFEVVDIDSYKIDQ 419 Query: 426 LLVTR 430 LLVTR Sbjct: 420 LLVTR 424 >ytfL [R] COG1253 Hemolysins and related proteins containing CBS domains Eco Escherichia coli K12 Length = 447 Score = 478 bits (1230), Expect = e-134, Method: Compositional matrix adjust. Identities = 235/425 (55%), Positives = 310/425 (72%), Gaps = 1/425 (0%) Query: 6 IFTSLLLILLLVVVSAFLSCAEISIAASRKIRLEMMSKEGVHNADRVLSLQAQPGNFFTV 65 + S+L+IL L+ VSAF S +EIS+AASRKI+L++++ EG NA RVL++Q PG FFTV Sbjct: 1 MLNSILVILCLIAVSAFFSMSEISLAASRKIKLKLLADEGNINAQRVLNMQENPGMFFTV 60 Query: 66 VQIGLNAVAILGGVVGEPALTPHMREIVSTFYVGPLLENISFAMSFLVVTAFFILFADLM 125 VQIGLNAVAILGG+VG+ A +P + S + L E +SF +SF +VT FILFADL Sbjct: 61 VQIGLNAVAILGGIVGDAAFSPAFHSLFSRYMSAELSEQLSFILSFSLVTGMFILFADLT 120 Query: 126 PKRLAMAAPERAAVALVQPMLLLETLFRPLVWFFNSLSKWIFTLFGLPQVRQDVITPSEI 185 PKR+ M APE A+ ++ PM + PLVWFFN L+ IF +F LP VR+D IT +I Sbjct: 121 PKRIGMIAPEAVALRIINPMRFCLYVCTPLVWFFNGLANIIFRIFKLPMVRKDDITSDDI 180 Query: 186 HAMVDAGAQAGVLLTQEHHLIENVFELESRYVPSAMTPRDSIVYFLLTDSEDMIRQKIID 245 +A+V+AGA AGVL QEH LIENVFELESR VPS+MTPR+++++F L + E ++ K+ + Sbjct: 181 YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRENVIWFDLHEDEQSLKNKVAE 240 Query: 246 HPHSRFLVCDGHIDAVLGYIDSKDVLKRLLKGEQFSLADKGLVHTPLSIPDSLNLWEVLE 305 HPHS+FLVC+ ID ++GY+DSKD+L R+L + +L + L +PD+L L E LE Sbjct: 241 HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLALNSGVQIRNTLIVPDTLTLSEALE 300 Query: 306 RMKAMDEDLAIVVNEYALVVGIISITDVTGVLMGNLLAITEEEQQIVRRDENSWLMDGLT 365 K ED A+++NEYALVVGII++ DV LMG+L+ EE QIV RDENSWL+DG T Sbjct: 301 SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEE-QIVARDENSWLIDGGT 359 Query: 366 PLNDVMNELDIDEYPNPVGYETLSGFIMYMLRKIPKKTDFVLFSDFKFEVVDIEGNRINQ 425 P++DVM LDIDE+P YET+ GF+M+MLRKIPK+TD V F+ +KFEVVDI+ RI+Q Sbjct: 360 PIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFAGYKFEVVDIDNYRIDQ 419 Query: 426 LLVTR 430 LLVTR Sbjct: 420 LLVTR 424 >ZytfL [R] COG1253 Hemolysins and related proteins containing CBS domains EcZ Escherichia coli O157:H7 EDL933 Length = 447 Score = 478 bits (1230), Expect = e-134, Method: Compositional matrix adjust. Identities = 235/425 (55%), Positives = 310/425 (72%), Gaps = 1/425 (0%) Query: 6 IFTSLLLILLLVVVSAFLSCAEISIAASRKIRLEMMSKEGVHNADRVLSLQAQPGNFFTV 65 + S+L+IL L+ VSAF S +EIS+AASRKI+L++++ EG NA RVL++Q PG FFTV Sbjct: 1 MLNSILVILCLIAVSAFFSMSEISLAASRKIKLKLLADEGNINAQRVLNMQENPGMFFTV 60 Query: 66 VQIGLNAVAILGGVVGEPALTPHMREIVSTFYVGPLLENISFAMSFLVVTAFFILFADLM 125 VQIGLNAVAILGG+VG+ A +P + S + L E +SF +SF +VT FILFADL Sbjct: 61 VQIGLNAVAILGGIVGDAAFSPAFHSLFSRYMSAELSEQLSFILSFSLVTGMFILFADLT 120 Query: 126 PKRLAMAAPERAAVALVQPMLLLETLFRPLVWFFNSLSKWIFTLFGLPQVRQDVITPSEI 185 PKR+ M APE A+ ++ PM + PLVWFFN L+ IF +F LP VR+D IT +I Sbjct: 121 PKRIGMIAPEAVALRIINPMRFCLYVCTPLVWFFNGLANIIFRIFKLPMVRKDDITSDDI 180 Query: 186 HAMVDAGAQAGVLLTQEHHLIENVFELESRYVPSAMTPRDSIVYFLLTDSEDMIRQKIID 245 +A+V+AGA AGVL QEH LIENVFELESR VPS+MTPR+++++F L + E ++ K+ + Sbjct: 181 YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRENVIWFDLHEDEQSLKNKVAE 240 Query: 246 HPHSRFLVCDGHIDAVLGYIDSKDVLKRLLKGEQFSLADKGLVHTPLSIPDSLNLWEVLE 305 HPHS+FLVC+ ID ++GY+DSKD+L R+L + +L + L +PD+L L E LE Sbjct: 241 HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLALNSGVQIRNTLIVPDTLTLSEALE 300 Query: 306 RMKAMDEDLAIVVNEYALVVGIISITDVTGVLMGNLLAITEEEQQIVRRDENSWLMDGLT 365 K ED A+++NEYALVVGII++ DV LMG+L+ EE QIV RDENSWL+DG T Sbjct: 301 SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEE-QIVARDENSWLIDGGT 359 Query: 366 PLNDVMNELDIDEYPNPVGYETLSGFIMYMLRKIPKKTDFVLFSDFKFEVVDIEGNRINQ 425 P++DVM LDIDE+P YET+ GF+M+MLRKIPK+TD V F+ +KFEVVDI+ RI+Q Sbjct: 360 PIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFAGYKFEVVDIDNYRIDQ 419 Query: 426 LLVTR 430 LLVTR Sbjct: 420 LLVTR 424 >ECs5196 [R] COG1253 Hemolysins and related proteins containing CBS domains Ecs Escherichia coli O157:H7 Length = 447 Score = 478 bits (1230), Expect = e-134, Method: Compositional matrix adjust. Identities = 235/425 (55%), Positives = 310/425 (72%), Gaps = 1/425 (0%) Query: 6 IFTSLLLILLLVVVSAFLSCAEISIAASRKIRLEMMSKEGVHNADRVLSLQAQPGNFFTV 65 + S+L+IL L+ VSAF S +EIS+AASRKI+L++++ EG NA RVL++Q PG FFTV Sbjct: 1 MLNSILVILCLIAVSAFFSMSEISLAASRKIKLKLLADEGNINAQRVLNMQENPGMFFTV 60 Query: 66 VQIGLNAVAILGGVVGEPALTPHMREIVSTFYVGPLLENISFAMSFLVVTAFFILFADLM 125 VQIGLNAVAILGG+VG+ A +P + S + L E +SF +SF +VT FILFADL Sbjct: 61 VQIGLNAVAILGGIVGDAAFSPAFHSLFSRYMSAELSEQLSFILSFSLVTGMFILFADLT 120 Query: 126 PKRLAMAAPERAAVALVQPMLLLETLFRPLVWFFNSLSKWIFTLFGLPQVRQDVITPSEI 185 PKR+ M APE A+ ++ PM + PLVWFFN L+ IF +F LP VR+D IT +I Sbjct: 121 PKRIGMIAPEAVALRIINPMRFCLYVCTPLVWFFNGLANIIFRIFKLPMVRKDDITSDDI 180 Query: 186 HAMVDAGAQAGVLLTQEHHLIENVFELESRYVPSAMTPRDSIVYFLLTDSEDMIRQKIID 245 +A+V+AGA AGVL QEH LIENVFELESR VPS+MTPR+++++F L + E ++ K+ + Sbjct: 181 YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRENVIWFDLHEDEQSLKNKVAE 240 Query: 246 HPHSRFLVCDGHIDAVLGYIDSKDVLKRLLKGEQFSLADKGLVHTPLSIPDSLNLWEVLE 305 HPHS+FLVC+ ID ++GY+DSKD+L R+L + +L + L +PD+L L E LE Sbjct: 241 HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLALNSGVQIRNTLIVPDTLTLSEALE 300 Query: 306 RMKAMDEDLAIVVNEYALVVGIISITDVTGVLMGNLLAITEEEQQIVRRDENSWLMDGLT 365 K ED A+++NEYALVVGII++ DV LMG+L+ EE QIV RDENSWL+DG T Sbjct: 301 SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEE-QIVARDENSWLIDGGT 359 Query: 366 PLNDVMNELDIDEYPNPVGYETLSGFIMYMLRKIPKKTDFVLFSDFKFEVVDIEGNRINQ 425 P++DVM LDIDE+P YET+ GF+M+MLRKIPK+TD V F+ +KFEVVDI+ RI+Q Sbjct: 360 PIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFAGYKFEVVDIDNYRIDQ 419 Query: 426 LLVTR 430 LLVTR Sbjct: 420 LLVTR 424 >STM4407 [R] COG1253 Hemolysins and related proteins containing CBS domains Sty Salmonella typhimurium LT2 Length = 447 Score = 476 bits (1225), Expect = e-134, Method: Compositional matrix adjust. Identities = 239/443 (53%), Positives = 313/443 (70%), Gaps = 2/443 (0%) Query: 6 IFTSLLLILLLVVVSAFLSCAEISIAASRKIRLEMMSKEGVHNADRVLSLQAQPGNFFTV 65 + S+ +I L+ VSAF S +EIS+AASRKI+L++++ EG NA RVL +Q PG FFTV Sbjct: 1 MLNSIFIIFCLIAVSAFFSISEISLAASRKIKLKLLADEGSINAQRVLKMQENPGMFFTV 60 Query: 66 VQIGLNAVAILGGVVGEPALTPHMREIVSTFYVGPLLENISFAMSFLVVTAFFILFADLM 125 VQIGLNAVAILGG+VG+ A +P + S + L E +SF +SF +VT FILFADL Sbjct: 61 VQIGLNAVAILGGIVGDAAFSPAFSALFSHYMSPELSEQLSFILSFSLVTGLFILFADLT 120 Query: 126 PKRLAMAAPERAAVALVQPMLLLETLFRPLVWFFNSLSKWIFTLFGLPQVRQDVITPSEI 185 PKR+ M APE A+ ++ PM +FRPLVW FN ++ IF LF +P VR+D IT +I Sbjct: 121 PKRIGMIAPEAVALRIINPMRFCLFVFRPLVWLFNGMANNIFRLFKIPMVRKDDITSDDI 180 Query: 186 HAMVDAGAQAGVLLTQEHHLIENVFELESRYVPSAMTPRDSIVYFLLTDSEDMIRQKIID 245 +A+V+AGA AGVL QEH LIENVFELESR VPS+MT R+SI++F L + E +++K+ + Sbjct: 181 YAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTSRESIIWFDLHEDEQSLKKKVAE 240 Query: 246 HPHSRFLVCDGHIDAVLGYIDSKDVLKRLLKGEQFSLADKGLVHTPLSIPDSLNLWEVLE 305 HPHS+FLVC+ ID ++GY+DSKD+L R+L + +L + L +PD+L L E LE Sbjct: 241 HPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSMALNSGVQIRNTLIVPDTLTLSEALE 300 Query: 306 RMKAMDEDLAIVVNEYALVVGIISITDVTGVLMGNLLAITEEEQQIVRRDENSWLMDGLT 365 K ED A+++NEYALVVGII++ DV LMG+L+ EE QIV RDENSWL+DG T Sbjct: 301 SFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEE-QIVARDENSWLVDGGT 359 Query: 366 PLNDVMNELDIDEYPNPVGYETLSGFIMYMLRKIPKKTDFVLFSDFKFEVVDIEGNRINQ 425 P++DVM LDIDE+P YET+ GF+M+MLRKIPK+TD V FS +KFEVVDI+ RI+Q Sbjct: 360 PIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFSGYKFEVVDIDNYRIDQ 419 Query: 426 LLVTRFKQDKGEKSDK-ADKSGK 447 LLVTR + K D GK Sbjct: 420 LLVTRLDNKSNVPAPKLPDAQGK 442