BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0028.0204.p (273 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1389 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 241 9e-64 YPO1228 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 220 3e-57 BH3116 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 169 6e-42 Rv0906 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 160 3e-39 MT0929 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 160 3e-39 >RSp1389 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Rso Ralstonia solanacearum Length = 362 Score = 241 bits (616), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 127/268 (47%), Positives = 160/268 (59%), Gaps = 20/268 (7%) Query: 17 YDPNKSNRTETGFRNNYPQPER---GSLLKWQWERLTQGLPKPPDNNYQFPVVKPDLAWL 73 Y+P+K + T GFRN YP R GS KW ER GLPKPP + V PDLA + Sbjct: 6 YEPSKPHHTPDGFRNRYPHAPRDSNGSAWKWMRERRRLGLPKPPTADLS--CVPPDLAAI 63 Query: 74 KANHGSPSVTWIGHATALVQLGGKNVLTDPMFSQRASPFSFIGPSRKVPLPVQISELPHI 133 + P VTWIGH T L+Q+ G NVLTDP+F +RASP F GP R P + +++LPHI Sbjct: 64 RRPSAVPQVTWIGHETLLLQIDGLNVLTDPVFGERASPLPFAGPRRHQPPGLSLAQLPHI 123 Query: 134 DVVVISHNHYDHLDQASVEQLNLQAGGPPLFLVPLGVRDWF--------LSLGITNVKEM 185 D+V++SHNHYDHL +ASV L Q GG P+F VPLG+ WF LS NV+ Sbjct: 124 DLVLLSHNHYDHLCRASVRALMRQPGGAPMFFVPLGIDRWFKRHVRGTRLSGEHVNVRAF 183 Query: 186 DWWDKTVMDNLDIYFVPATHWSARGVFDRSETLWGGWVIQAAAQQAGAEPFSVYFAGDTG 245 DW + ++F HWSARG++DR+ TLWG W + +F+GD G Sbjct: 184 DWDTEARFGPFSVHFCAVQHWSARGLYDRNRTLWGSWALLHPQ-------LRFWFSGDLG 236 Query: 246 YSKDFRDIGERFGRFDLALIPIGAYAPR 273 YS+D RDIG RFG FD+A I +GAY PR Sbjct: 237 YSQDTRDIGARFGHFDVAAIAVGAYEPR 264 >YPO1228 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Ype Yersinia pestis Length = 342 Score = 220 bits (561), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 116/267 (43%), Positives = 163/267 (61%), Gaps = 14/267 (5%) Query: 10 CSSSSKYYDPNKSNRTETGFRNNYPQPERGSLLK-WQWERLTQGLPKPPDNNYQFPVVKP 68 + + YYD +K + TE GF+N P LK W+ ER Q LPKPP Y P Sbjct: 14 MAKKNPYYDASKPHHTEFGFQNIEPVVHHPQDLKRWREERKRQSLPKPPQQGY--PQFVT 71 Query: 69 DLAWLKANHG--SPSVTWIGHATALVQLGGKNVLTDPMFSQRASPFSFIGPSRKVPLPVQ 126 D W +A+ ++ W+GHA+ L+++ G+ VL DP+ S R SP +F GP RK P+P Sbjct: 72 DW-WQQADFSGLQDALWWLGHASLLLRISGQAVLFDPVLSSRVSPVNFYGPQRKTPIPAS 130 Query: 127 ISELPHIDVVVISHNHYDHLDQASVEQLNLQAGGPPLFLVPLGVRDWFLSLGITNVKEMD 186 + +LP IDV+VISHNHYDHLD ++ QL L+ +FLVPLG+++W G +V E+D Sbjct: 131 VQQLPDIDVIVISHNHYDHLDVTTITQL-LRRFPDVVFLVPLGLKNWLRQHGARHVHELD 189 Query: 187 WWDKTVMDNLDIYFVPATHWSARGVFDRSETLWGGWVIQAAAQQAGAEPFSVYFAGDTGY 246 WWD+ ++ + + + VPA HWS R +DR+ +LW GWV++ + YF+GDTGY Sbjct: 190 WWDQRLVADFEFHCVPARHWSMRTPWDRNHSLWSGWVVKRGE-------VNFYFSGDTGY 242 Query: 247 SKDFRDIGERFGRFDLALIPIGAYAPR 273 + DIGE G F+ A +PIGAYAPR Sbjct: 243 CQQLLDIGEALGPFNYAALPIGAYAPR 269 >BH3116 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Bha Bacillus halodurans Length = 305 Score = 169 bits (428), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 89/230 (38%), Positives = 137/230 (59%), Gaps = 20/230 (8%) Query: 46 WERLTQGLPKPPDNNYQFPVV-KPDLAWLKANHGSPSVTWIGHATALVQLGGKNVLTDPM 104 W+ L + K D + P + ++ LK N S TWIGH++ L+Q+ G N+LTDP+ Sbjct: 21 WKCLRERWSKSKDLSIHIPRADERNVEELKKNRTKTSYTWIGHSSFLLQMKGLNILTDPV 80 Query: 105 FSQRASPFSFIGPSRKVPLP-VQISELPHIDVVVISHNHYDHLDQASVEQLNLQAGGPPL 163 F++ ++G S+++ P + I ELP ID+VVISH HYDHL+ +++ L G P+ Sbjct: 81 FAK------YLGFSKRLISPGLSIDELPEIDIVVISHGHYDHLEFSTLRSLK----GEPI 130 Query: 164 FLVPLGVRDWFLSLGITNVKEMDWWDKTVMDNLDIYFVPATHWSARGVFDRSETLWGGWV 223 F VP G+ F G+ V+E +WWD +L I+FVPA HW+ R +FD + + WGGWV Sbjct: 131 FYVPAGLNLLFQKKGLHRVEEANWWDTFQHQDLTIHFVPAQHWTRRSLFDTNTSHWGGWV 190 Query: 224 IQAAAQQAGAEPFSVYFAGDTGYSKDFRDIGERFGRFDLALIPIGAYAPR 273 +++ + + YF GDTGY + F++IG++F D +PIG+Y P Sbjct: 191 LESDEE-------TNYFVGDTGYFRGFQEIGKKFA-LDTVFMPIGSYEPE 232 >Rv0906 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Mtu Mycobacterium tuberculosis H37Rv Length = 372 Score = 160 bits (405), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 105/275 (38%), Positives = 140/275 (50%), Gaps = 26/275 (9%) Query: 5 AGLTACSSSSKYYDPNKSNRTETGFRNNYPQP----ERGSLLKWQWE---RLTQGLPKPP 57 A L A ++S + N + F N P +R L WE R + P P Sbjct: 30 AALGADAASIRAVSEQSPNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAP 89 Query: 58 DNNYQFPVVKPDLAWLKANHGSPSVTWIGHATALVQLGGKNVLTDPMFSQRASPFSFIGP 117 P+ P++ + + +V+W GH+TAL+++ G VLTDP++S R SP +GP Sbjct: 90 -----IPLASPNI--YRGDASRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVGP 142 Query: 118 SRKVPLPVQISELPHIDVVVISHNHYDHLDQASVEQLNLQAGGPPLFLVPLGVRDWFLSL 177 R P PVQ++ LP +D VVISH+HYDHLD +V L P FLVPLGV S Sbjct: 143 QRLHPPPVQLAALPAVDAVVISHDHYDHLDIDTVVALVGMQRAP--FLVPLGVGAHLRSW 200 Query: 178 GI--TNVKEMDWWDKTVMDNLDIYFVPATHWSARGVFDRSETLWGGWVIQAAAQQAGAEP 235 G+ + E+DW +D L + VPA H+S R R+ TLW W +A Sbjct: 201 GVPQDRIVELDWNQSAQVDELTVVCVPARHFSGR-FLSRNTTLWASWAFVGPNHRA---- 255 Query: 236 FSVYFAGDTGYSKDFRDIGERFGRFDLALIPIGAY 270 YF GDTGY+K F IG G FDL L+PIGAY Sbjct: 256 ---YFGGDTGYTKSFTQIGADHGPFDLTLLPIGAY 287 >MT0929 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold MtC Mycobacterium tuberculosis CDC1551 Length = 372 Score = 160 bits (405), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 105/275 (38%), Positives = 140/275 (50%), Gaps = 26/275 (9%) Query: 5 AGLTACSSSSKYYDPNKSNRTETGFRNNYPQP----ERGSLLKWQWE---RLTQGLPKPP 57 A L A ++S + N + F N P +R L WE R + P P Sbjct: 30 AALGADAASIRAVSEQSPNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAP 89 Query: 58 DNNYQFPVVKPDLAWLKANHGSPSVTWIGHATALVQLGGKNVLTDPMFSQRASPFSFIGP 117 P+ P++ + + +V+W GH+TAL+++ G VLTDP++S R SP +GP Sbjct: 90 -----IPLASPNI--YRGDASRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVGP 142 Query: 118 SRKVPLPVQISELPHIDVVVISHNHYDHLDQASVEQLNLQAGGPPLFLVPLGVRDWFLSL 177 R P PVQ++ LP +D VVISH+HYDHLD +V L P FLVPLGV S Sbjct: 143 QRLHPPPVQLAALPAVDAVVISHDHYDHLDIDTVVALVGMQRAP--FLVPLGVGAHLRSW 200 Query: 178 GI--TNVKEMDWWDKTVMDNLDIYFVPATHWSARGVFDRSETLWGGWVIQAAAQQAGAEP 235 G+ + E+DW +D L + VPA H+S R R+ TLW W +A Sbjct: 201 GVPQDRIVELDWNQSAQVDELTVVCVPARHFSGR-FLSRNTTLWASWAFVGPNHRA---- 255 Query: 236 FSVYFAGDTGYSKDFRDIGERFGRFDLALIPIGAY 270 YF GDTGY+K F IG G FDL L+PIGAY Sbjct: 256 ---YFGGDTGYTKSFTQIGADHGPFDLTLLPIGAY 287