BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0028.0181.p (437 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 425 e-118 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 390 e-108 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 385 e-107 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 353 4e-97 PA4126 [GEPR] COG0477 Permeases of the major facilitator superfa... 325 9e-89 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 425 bits (1092), Expect = e-118, Method: Compositional matrix adjust. Identities = 229/424 (54%), Positives = 305/424 (71%), Gaps = 1/424 (0%) Query: 8 AATAAPPASSSASLEATYGKIAWRLIPFLVFLFVLAWIDRVNVGFAKLQMLQDLQFSEAV 67 +A A PP S+S EATY K++WRLIPFL+ +V+A++DRVNVGFAKLQML DL+FSE V Sbjct: 11 SAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETV 70 Query: 68 YGLGAGIFFIGYFLFEVPSNLLLEKIGARKTLARITILWGLASMAMAYVTTPISFYVLRF 127 YGLGAGIFFIGYFLFEVPSN++L ++GAR +ARI I WGL S AM +VTTP FYV+RF Sbjct: 71 YGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRF 130 Query: 128 LLGIFEAGFFPGVVLYLTYWFPAKRRARVNGLFMTSFAIAGAVGGPIAGLIMSSMEGVGH 187 LLG+ EAGFFPG++LYLTYW+PA+RR R FMT+ A++G +GGPI+G + + GV Sbjct: 131 LLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYG 190 Query: 188 LANWQWLFIIEGIPSILAGFAVLAWLPEKPANAKWLSDAEKTAVTQVLAAENSAPGKHFS 247 LA WQW+F+IEGIPS++ G VLA+L + ++A+WL+D EK +T+ +AAE A + Sbjct: 191 LAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEE-AQKEDAP 249 Query: 248 FKDACTNYRVWVCAAVYFCVVSGNATIAFWAPSIIKEIGVKGNLQIGLISAIPFVAGTLA 307 + RVW+ + +YF V G ++FW P++IK+ GV L +GL++AIP+ A +A Sbjct: 250 IAAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVA 309 Query: 308 MVWNGFHSDKTGERRLHSAIATLIACIGLIATGMTLGNATLALCSLTLAAIGILAAFPVF 367 MV +D+T ERR H AI L IGL+ + + N TLA+ +LTL +GIL P+F Sbjct: 310 MVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLF 369 Query: 368 WSIPGAFLAGTAAAGGIALINSIGNLAGFVAPYMIGALKTSTGSLSSGLYFVAALEFLAS 427 WS+P AFLAGT AA GIALINS+GNLAGF++PY +G LK +T S SG+Y +AA L + Sbjct: 370 WSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGA 429 Query: 428 FLVV 431 L + Sbjct: 430 LLTL 433 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 390 bits (1002), Expect = e-108, Method: Compositional matrix adjust. Identities = 204/433 (47%), Positives = 284/433 (65%), Gaps = 2/433 (0%) Query: 4 SPSAAATAAPPASSSASLEATYGKIAWRLIPFLVFLFVLAWIDRVNVGFAKLQMLQDLQF 63 S S+ + + P A Y K W L+P L+ +VL ++DRVNVGFAKLQM DLQF Sbjct: 2 SESSTESLSQPTQLQEENNA-YRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQF 60 Query: 64 SEAVYGLGAGIFFIGYFLFEVPSNLLLEKIGARKTLARITILWGLASMAMAYVTTPISFY 123 S+ VYGLGAG+FFIGYF E+PSNL+L ++GAR +ARI I WG+ S MA+VTTP+SFY Sbjct: 61 SDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFY 120 Query: 124 VLRFLLGIFEAGFFPGVVLYLTYWFPAKRRARVNGLFMTSFAIAGAVGGPIAGLIMSSME 183 V+RFLLG+ EAGFFPG++LY++YWFP+ RR RV GLF+ S ++G +G P++G IM Sbjct: 121 VMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFN 180 Query: 184 GVGHLANWQWLFIIEGIPSILAGFAVLAWLPEKPANAKWLSDAEKTAVTQVLAAENSAPG 243 G A WQW+FI+EGIPS+L G ++ L ++ +A WL+D EK + Q +A Sbjct: 181 GFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKD-ILQTNIENEAAHY 239 Query: 244 KHFSFKDACTNYRVWVCAAVYFCVVSGNATIAFWAPSIIKEIGVKGNLQIGLISAIPFVA 303 H +DA RVW+ +YFC++SG TI FW P++I++ GVK L IG ++AIP A Sbjct: 240 AHSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAA 299 Query: 304 GTLAMVWNGFHSDKTGERRLHSAIATLIACIGLIATGMTLGNATLALCSLTLAAIGILAA 363 + M+ +D+ ERR H A+ ++ +G+I + N +A+ LT+ A+G L+ Sbjct: 300 AAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALST 359 Query: 364 FPVFWSIPGAFLAGTAAAGGIALINSIGNLAGFVAPYMIGALKTSTGSLSSGLYFVAALE 423 P+FWS+P AFL G+AAA GIA INS GNL GFVAPYM+G LK T S ++G+ ++ Sbjct: 360 IPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTL 419 Query: 424 FLASFLVVVFVKK 436 F+ + LV + K Sbjct: 420 FIGAALVFLIPAK 432 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 385 bits (990), Expect = e-107, Method: Compositional matrix adjust. Identities = 207/409 (50%), Positives = 271/409 (66%), Gaps = 4/409 (0%) Query: 8 AATAAP-PASSSASLEATYGKIAWRLIPFLVFLFVLAWIDRVNVGFAKLQMLQDLQFSEA 66 AA A P A S + Y + R++PFL ++ A++DR+N+GFAKLQM DL S+A Sbjct: 2 AANAIPAQAHSGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDA 61 Query: 67 VYGLGAGIFFIGYFLFEVPSNLLLEKIGARKTLARITILWGLASMAMAYVTTPISFYVLR 126 YGLGAGIFF GY LFEVPSNLLL KIGAR+TL+RI ILWG+ S +M +VT +FY LR Sbjct: 62 AYGLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALR 121 Query: 127 FLLGIFEAGFFPGVVLYLTYWFPAKRRARVNGLFMTSFAIAGAVGGPIAGLIMSSMEGVG 186 FLLG+FEAGF PG++ YLT W+P +R AR + + + + G +GGP + IM G G Sbjct: 122 FLLGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAG 181 Query: 187 HLANWQWLFIIEGIPSILAGFAVLAWLPEKPANAKWLSDAEKTAVTQVLAAENSAPGKHF 246 LA WQW+F+ EGIPSIL G A +L +KPA+A+WL+DA+K + +A +APG+ Sbjct: 182 GLAGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIA--RAAPGQAS 239 Query: 247 SFKDACTNYRVWVCAAVYFCVVSGNATIAFWAPSIIKEIGVKGNLQIGLISAIPFVAGTL 306 SF A T +++V AA YFC++ G + FW PSI+K G+ QIGL SAIP +A + Sbjct: 240 SFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIV 299 Query: 307 AMVWNGFHSDKTGERRLHSAIATLIACIGLIATGMTLGNATLALCSLTLAAIGILAAFPV 366 AM G SD+ GER LHSAI ++ GL+A + AL S+TLA+ I A++ V Sbjct: 300 AMYALGRRSDRRGERHLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFASYSV 358 Query: 367 FWSIPGAFLAGTAAAGGIALINSIGNLAGFVAPYMIGALKTSTGSLSSG 415 FW+IP L GTAAAGGIALINSIG GF +P +IG K +TGSL +G Sbjct: 359 FWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 353 bits (906), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 185/408 (45%), Positives = 263/408 (64%), Gaps = 1/408 (0%) Query: 24 TYGKIAWRLIPFLVFLFVLAWIDRVNVGFAKLQMLQDLQFSEAVYGLGAGIFFIGYFLFE 83 TY K+A+R+IP L+ +++A++DRVNVGFAKLQM ++L FSEA+YGLGAG+FFIGYF FE Sbjct: 36 TYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGYFFFE 95 Query: 84 VPSNLLLEKIGARKTLARITILWGLASMAMAYVTTPISFYVLRFLLGIFEAGFFPGVVLY 143 +PSN+LL K+GAR +ARI I WGL S A+V T FY+LRFLLG EAGF+PGV+LY Sbjct: 96 IPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPGVILY 155 Query: 144 LTYWFPAKRRARVNGLFMTSFAIAGAVGGPIAGLIMSSMEGVGHLANWQWLFIIEGIPSI 203 LTYWFP+ RR + LF AG G P++G IM WQW+F++E IP++ Sbjct: 156 LTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEAIPAV 215 Query: 204 LAGFAVLAWLPEKPANAKWLSDAEKTAVTQVLAAENSAPGKHFSFKDACTNYRVWVCAAV 263 + G +L +L AKWL++ EK +++ + A++ S N +WV + Sbjct: 216 VLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASHSLMSLVKNPMLWVMMLI 275 Query: 264 YFCVVSGNATIAFWAPSIIKEIGVKGNLQIGLISAIPFVAGTLAMVWNGFHSDKTGERRL 323 YFC V G + W P++I+ GV N+ IGL+ AIPF+ +AMV +D ERR Sbjct: 276 YFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSADHYRERRW 335 Query: 324 HSAIATLIACIGLIATGMTLGNATLALCSLTLAAIGILAAFPVFWSIPGAFLAGTAAAGG 383 H + L+ +G + + N T+++ L++AA G+LA P+FWS+P A L+G AAA G Sbjct: 336 HLVVPALLGAVGFVVAA-SATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILSGAAAAAG 394 Query: 384 IALINSIGNLAGFVAPYMIGALKTSTGSLSSGLYFVAALEFLASFLVV 431 IALINS+ NLAGF++PYM+G ++ +T S G+Y +A L + +V+ Sbjct: 395 IALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIVL 442 >PA4126 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 434 Score = 325 bits (834), Expect = 9e-89, Method: Compositional matrix adjust. Identities = 175/388 (45%), Positives = 251/388 (64%), Gaps = 1/388 (0%) Query: 22 EATYGKIAWRLIPFLVFLFVLAWIDRVNVGFAKLQMLQDLQFSEAVYGLGAGIFFIGYFL 81 ++T+ ++ WRL+P L+ +V A +DR+N+GFAKLQM DL FS+ VYGLGAG+FFI Y L Sbjct: 16 DSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYAL 75 Query: 82 FEVPSNLLLEKIGARKTLARITILWGLASMAMAYVTTPISFYVLRFLLGIFEAGFFPGVV 141 F +PSNL+LE+IG R+ +A + ++WG S AM V T FY+LRFLLG+ EAGFFPG++ Sbjct: 76 FGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGIL 135 Query: 142 LYLTYWFPAKRRARVNGLFMTSFAIAGAVGGPIAGLIMSSMEGVGHLANWQWLFIIEGIP 201 +YL WFPA+RR ++ LF + +AG +GGP++G I+ L WQW+F+IEG+P Sbjct: 136 VYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIEGLP 195 Query: 202 SILAGFAVLAWLPEKPANAKWLSDAEKTAVTQVLAAENSAPGKHFSFKDACTNYRVWVCA 261 +L G V LPE WLSD +K + + LA E SF +N +VW+ Sbjct: 196 VVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTIT-SFSGIFSNPQVWLLV 254 Query: 262 AVYFCVVSGNATIAFWAPSIIKEIGVKGNLQIGLISAIPFVAGTLAMVWNGFHSDKTGER 321 A+YF V+ TIAFW PS+I G+ + +IG++SA+P++AG M++ G SD+ ER Sbjct: 255 AIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRER 314 Query: 322 RLHSAIATLIACIGLIATGMTLGNATLALCSLTLAAIGILAAFPVFWSIPGAFLAGTAAA 381 R H I L+A GL + +A L + L +A +G AA P+FW +P AFL+ A Sbjct: 315 RWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLA 374 Query: 382 GGIALINSIGNLAGFVAPYMIGALKTST 409 GIALI+S G++A F+APY+IG ++ +T Sbjct: 375 AGIALISSFGSIAAFLAPYLIGWMRDTT 402