BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0028.0035.p (446 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1576 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 595 e-170 NMA1991 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 410 e-114 NMB1735 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolas... 409 e-114 PA0934 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolase... 380 e-105 VC2451 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolase... 358 1e-98 >RSc1576 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Rso Ralstonia solanacearum Length = 746 Score = 595 bits (1533), Expect = e-170, Method: Compositional matrix adjust. Identities = 292/433 (67%), Positives = 342/433 (78%), Gaps = 15/433 (3%) Query: 1 VRAFRVIVDDVKTCYSVLGIVHNIWTPIPEEFDDYISRPKQNGYQSLHTVVMAEDGRALE 60 VRAFRVIVDD+K CY+VLG VH++W PIP+EFDDYISRPK NGY+SLHTVV+ +DGRALE Sbjct: 279 VRAFRVIVDDIKDCYTVLGFVHHMWQPIPKEFDDYISRPKTNGYKSLHTVVIGDDGRALE 338 Query: 61 VQIRTHEMHHFAEYGVAAHWRYKESGGSNFSAQ-----KYDEKIAWLRQLLAWKNEVTDA 115 VQIRT EMHHFAEYGVAAHWRYKE+G ++ Q +YDEKIAWLRQLLAWK++ Sbjct: 339 VQIRTREMHHFAEYGVAAHWRYKEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHT 398 Query: 116 VVDQEEVRRDWVQKLKSATLDERIYVLTPQARVIELPSGATPIDFAYHLHSDVGHRCRGA 175 V ++ W ++LK LD+ IYVLTPQARVI LP GATP+DFAY+LHSD+GHRCRGA Sbjct: 399 VAQEDS---PW-EQLKHTELDDHIYVLTPQARVIALPQGATPVDFAYYLHSDLGHRCRGA 454 Query: 176 RVDGVMVPLNTTLKNGQTVEIITAKSGPGVGPSRDWLSAD--YTASSRTRSKIRAWFNAI 233 RVDG MVPLNT LKNGQTVEI+T K G GPSRDWL+ + Y AS+R R+K+RAWFNA+ Sbjct: 455 RVDGTMVPLNTPLKNGQTVEIVTVKQG---GPSRDWLNPELHYLASNRARAKVRAWFNAL 511 Query: 234 EQQETLSVGRGLLEKTLQREGKTAVNLEELAQKLGFAKVDDLCLALAKEEFSLRHVEQAL 293 E +ETL+ GR L++KTLQREGKTAVNLEELA KLGF D+L +AK+EFSLRHVE L Sbjct: 512 ELEETLAQGRILIDKTLQREGKTAVNLEELAAKLGFKTPDELYAMVAKDEFSLRHVEAVL 571 Query: 294 HQGEEKKPEIDDEALITRKSRASSIVQGAKSGVLVVGTDGLLTQLARCCKPAPPDVIAGF 353 DDEA IT+KSRA+S+ +GAKSGVLVVG D LLTQ++RCCKPAPPD+I GF Sbjct: 572 RTDGAPPAPADDEASITKKSRATSVARGAKSGVLVVGVDSLLTQMSRCCKPAPPDLIVGF 631 Query: 354 VTRGKGVSIHRVNCKNFAEMSLHAPERVIQTTWGAPARDTVYPVDIFVLASDRQGLLRDI 413 VTRG+GVSIHR NC F +++ AP RVIQT WG + VYPVDI V A DRQGLLRDI Sbjct: 632 VTRGRGVSIHRQNCATFQQLAARAPGRVIQTEWGNRG-EAVYPVDIHVEALDRQGLLRDI 690 Query: 414 SDIFLRDKINVIG 426 S+I R+KINV G Sbjct: 691 SEILSREKINVTG 703 >NMA1991 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases NmA Neisseria meningitidis Z2491 Length = 769 Score = 410 bits (1053), Expect = e-114, Method: Compositional matrix adjust. Identities = 212/427 (49%), Positives = 282/427 (66%), Gaps = 22/427 (5%) Query: 1 VRAFRVIVDDVKTCYSVLGIVHNIWTPIPEEFDDYISRPKQNGYQSLHTVVMAEDGRALE 60 +RA R++VD V CY+ LGIVH++W PIP EFDDYI+ PK NGY+SLHTV++ + + +E Sbjct: 317 IRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVE 376 Query: 61 VQIRTHEMHHFAEYGVAAHWRYKESGGSNFSAQKYDEKIAWLRQLLAWKNEVTDAVVDQE 120 VQIRT +MH F E+GVAAHWRYKE GG SA Y++KIAWLRQLL W+ + E Sbjct: 377 VQIRTFDMHQFNEFGVAAHWRYKE-GGKGDSA--YEQKIAWLRQLLDWRENMA------E 427 Query: 121 EVRRDWVQKLKSATLDERIYVLTPQARVIELPSGATPIDFAYHLHSDVGHRCRGARVDGV 180 + D K+ ++ IYVLTP +V+ LP+GATPIDFAY LHS +G RCRGA+V+G Sbjct: 428 SGKEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQ 487 Query: 181 MVPLNTTLKNGQTVEIITAKSGPGVGPSRDWLSADYTASSRTRSKIRAWFNAIEQQETLS 240 +VPL+T L+NGQ VEIITAK G PS +WL + S++ KIRA+ I QQ + Sbjct: 488 IVPLSTPLENGQRVEIITAKEG---HPSVNWLYEGWVKSNKAIGKIRAY---IRQQNADT 541 Query: 241 V---GRGLLEKTLQREGKTAVNLEELAQKLGFAKVDDLCLALAKEEFSLRHVEQALHQGE 297 V GR L+K L + NL+ELA+ LG+ K +DL A+ + E S R +++A Sbjct: 542 VREEGRVQLDKQLAKLTPKP-NLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLN 600 Query: 298 EKKPEIDDEALITRKSRASSIVQGAKSGVLVVGTDGLLTQLARCCKPAPPDVIAGFVTRG 357 E P E I ++S+ I +G K+GVL+ G DGL+T LA+CCKPAPPD I GFVTR Sbjct: 601 EPPPVPVSETTIVKQSK---IKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIVGFVTRD 657 Query: 358 KGVSIHRVNCKNFAEMSLHAPERVIQTTWGAPARDTVYPVDIFVLASDRQGLLRDISDIF 417 +G+S+HR C +F ++ HAPE+V+ +W A V+ VDI + A DR GLLRD+SD Sbjct: 658 RGISVHRKTCPSFRHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDAL 717 Query: 418 LRDKINV 424 R K+NV Sbjct: 718 ARHKLNV 724 >NMB1735 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Nme Neisseria meningitidis MC58 Length = 737 Score = 409 bits (1050), Expect = e-114, Method: Compositional matrix adjust. Identities = 212/427 (49%), Positives = 282/427 (66%), Gaps = 22/427 (5%) Query: 1 VRAFRVIVDDVKTCYSVLGIVHNIWTPIPEEFDDYISRPKQNGYQSLHTVVMAEDGRALE 60 +RA R++VD V CY+ LGIVH++W PIP EFDDYI+ PK NGY+SLHTV++ + + +E Sbjct: 285 IRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVE 344 Query: 61 VQIRTHEMHHFAEYGVAAHWRYKESGGSNFSAQKYDEKIAWLRQLLAWKNEVTDAVVDQE 120 VQIRT +MH F E+GVAAHWRYKE GG SA Y++KIAWLRQLL W+ + E Sbjct: 345 VQIRTFDMHQFNEFGVAAHWRYKE-GGKGDSA--YEQKIAWLRQLLDWRENMA------E 395 Query: 121 EVRRDWVQKLKSATLDERIYVLTPQARVIELPSGATPIDFAYHLHSDVGHRCRGARVDGV 180 + D K+ ++ IYVLTP +V+ LP+GATPIDFAY LHS +G RCRGA+V+G Sbjct: 396 SGKEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQ 455 Query: 181 MVPLNTTLKNGQTVEIITAKSGPGVGPSRDWLSADYTASSRTRSKIRAWFNAIEQQETLS 240 +VPL+T L+NGQ VEIITAK G PS +WL + S++ KIRA+ I QQ + Sbjct: 456 IVPLSTPLENGQRVEIITAKEG---HPSVNWLYEGWVKSNKAIGKIRAY---IRQQNADT 509 Query: 241 V---GRGLLEKTLQREGKTAVNLEELAQKLGFAKVDDLCLALAKEEFSLRHVEQALHQGE 297 V GR L+K L + NL+ELA+ LG+ K +DL A+ + E S R +++A Sbjct: 510 VREEGRVQLDKQLAKLTPKP-NLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLN 568 Query: 298 EKKPEIDDEALITRKSRASSIVQGAKSGVLVVGTDGLLTQLARCCKPAPPDVIAGFVTRG 357 E P E I ++S+ I +G K+GVL+ G DGL+T LA+CCKPAPPD I GFVTR Sbjct: 569 EPPPVPVSETTIVKQSK---IKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIIGFVTRE 625 Query: 358 KGVSIHRVNCKNFAEMSLHAPERVIQTTWGAPARDTVYPVDIFVLASDRQGLLRDISDIF 417 +G+S+HR C +F ++ HAPE+V+ +W A V+ VDI + A DR GLLRD+SD Sbjct: 626 RGISVHRKTCPSFQHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDAL 685 Query: 418 LRDKINV 424 R K+NV Sbjct: 686 ARHKLNV 692 >PA0934 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Pae Pseudomonas aeruginosa Length = 747 Score = 380 bits (976), Expect = e-105, Method: Compositional matrix adjust. Identities = 192/428 (44%), Positives = 268/428 (62%), Gaps = 17/428 (3%) Query: 1 VRAFRVIVDDVKTCYSVLGIVHNIWTPIPEEFDDYISRPKQNGYQSLHTVVMAEDGRALE 60 VRA RV+V +++ CY+ LGIVH +W IP+EFDDYI+ PK+NGY+SLHT V+ +G+ LE Sbjct: 287 VRAVRVLVPEMRDCYTALGIVHTLWRHIPKEFDDYIANPKENGYRSLHTAVIGPEGKVLE 346 Query: 61 VQIRTHEMHHFAEYGVAAHWRYKESGGSNFSAQKYDEKIAWLRQLLAWKNEVTDAVVDQE 120 VQIRTH MH AE GV AHWRYK + S+ Y+EKI+WLRQ+L W E+ D E Sbjct: 347 VQIRTHSMHEEAELGVCAHWRYKGT-DVKASSNHYEEKISWLRQVLEWHEELGDIGGLAE 405 Query: 121 EVRRDWVQKLKSATLDERIYVLTPQARVIELPSGATPIDFAYHLHSDVGHRCRGARVDGV 180 ++R D +R+YV TP I+LP GATP+DFAY +H++VGH CRGA+++G Sbjct: 406 QLRVD--------IEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEVGHNCRGAKINGR 457 Query: 181 MVPLNTTLKNGQTVEIITAKSGPGVGPSRDWLSAD--YTASSRTRSKIRAWFNAIEQQET 238 +VPLN +L+ G+ VEIIT K GPSRDWL+++ Y +SR R+KI WF + + Sbjct: 458 IVPLNYSLQTGEQVEIITGKHS---GPSRDWLNSNLGYVTTSRARAKIVHWFKLQARDQN 514 Query: 239 LSVGRGLLEKTLQREGKTAVNLEELAQKLGFAKVDDLCLALAKEEFSLRHVEQALHQGEE 298 ++ G+ L+E+ L R V+ + LA+K +D+ AL + L H+ Q E Sbjct: 515 VAAGKALIERELSRLALPPVDFDRLAEKANVRTAEDMFAALGAGDLRLAHLVNYAQQLVE 574 Query: 299 KKPEIDDEALITRKSRASSIVQGAKSGVLVVGTDGLLTQLARCCKPAPPDVIAGFVTRGK 358 P+ D E L + S I G + V + G LLTQ+A CC+P P D I G++T G+ Sbjct: 575 --PDRDSEQLELIPRKPSKIGHGKRGDVQIQGVGNLLTQMAGCCQPLPGDPIVGYITLGR 632 Query: 359 GVSIHRVNCKNFAEMSLHAPERVIQTTWGAPARDTVYPVDIFVLASDRQGLLRDISDIFL 418 GV+IHR +C +++ PER+IQ +WG P YPVDI + A DR GLLRD+S + L Sbjct: 633 GVTIHRQDCATALQLAGREPERMIQVSWG-PEPVRTYPVDIAIRAYDRSGLLRDVSQVLL 691 Query: 419 RDKINVIG 426 ++INV+ Sbjct: 692 NERINVLA 699 >VC2451 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases Vch Vibrio cholerae Length = 738 Score = 358 bits (920), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 179/430 (41%), Positives = 268/430 (62%), Gaps = 20/430 (4%) Query: 1 VRAFRVIVDDVKTCYSVLGIVHNIWTPIPEEFDDYISRPKQNGYQSLHTVVMAEDGRALE 60 VRA R+I D ++ CY+ LGIVH + +P EFDDY++ PK NGYQS+HTV++ +G+ +E Sbjct: 275 VRAVRIIADKLQDCYAALGIVHTKYKHLPNEFDDYVANPKPNGYQSIHTVILGPEGKTIE 334 Query: 61 VQIRTHEMHHFAEYGVAAHWRYKESGGSNFSAQKYDEKIAWLRQLLAWKNEVTDAVVDQE 120 +QIRT +MH +E GVAAHW+YKE GS+ + YDEKI WLR+LL W+ E++D+ Sbjct: 335 IQIRTKQMHEESELGVAAHWKYKE--GSSAARSGYDEKITWLRKLLDWQEEMSDS----- 387 Query: 121 EVRRDWVQKLKSATLDERIYVLTPQARVIELPSGATPIDFAYHLHSDVGHRCRGARVDGV 180 + + +L+S D+R+Y TP+ V++LP GATP+DFAYH+HS+VGHRC GA+V G Sbjct: 388 ---GEMLDELRSQVFDDRVYAFTPKGDVVDLPMGATPLDFAYHIHSEVGHRCIGAKVAGR 444 Query: 181 MVPLNTTLKNGQTVEIITAKSGPGVGPSRDWL--SADYTASSRTRSKIRAWFNAIEQQET 238 +VP L+ G VEIITAK PSRDWL S + S R R+KI AWF +++ Sbjct: 445 IVPFTHKLQMGDQVEIITAKEP---NPSRDWLNPSLGFVHSGRARAKINAWFRKQSREKN 501 Query: 239 LSVGRGLLEKTLQREGKTAVNLEELA-QKLGFAKVDDLCLALAKEEFSLRHVEQALHQGE 297 L GR +LE L + G + E A ++ VD++ + + + + + ++ Sbjct: 502 LEAGREILEIELAKIGANLKHAEAYALKRFNVNSVDEMYVGIGSGDLRINQIVNHINALV 561 Query: 298 EKKPEIDDEALITRKSRASSIV---QGAKSGVLVVGTDGLLTQLARCCKPAPPDVIAGFV 354 K +++ L K + + + + K V+V G D L+T LARCC+P P D I G++ Sbjct: 562 NKPTAEEEDKLALEKLQENKTLTPNRPHKDAVVVEGVDNLMTHLARCCQPIPGDEIRGYI 621 Query: 355 TRGKGVSIHRVNCKNFAEMSLHAPERVIQTTWGAPARDTVYPVDIFVLASDRQGLLRDIS 414 T+G+G+S+HR +C+ E+SLHAPER+I T WG+ + Y + + V A +R GLL+DI+ Sbjct: 622 TQGRGISVHRSDCEQLEELSLHAPERIIDTVWGSGFVGS-YLLTVRVEAMERSGLLKDIT 680 Query: 415 DIFLRDKINV 424 + +K+ V Sbjct: 681 TLLANEKVKV 690