BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0112.p (437 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 575 e-164 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 508 e-144 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 467 e-131 PA4126 [GEPR] COG0477 Permeases of the major facilitator superfa... 387 e-107 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 359 8e-99 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 575 bits (1481), Expect = e-164, Method: Compositional matrix adjust. Identities = 283/433 (65%), Positives = 347/433 (80%), Gaps = 1/433 (0%) Query: 5 STSGVGLDVNDKSKDGLYKKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSQDLGFSETV 64 S + + ++ Y+KV +RI+P LM+CY+IAYLDRVNVGFAKLQMS++LGFSE + Sbjct: 20 KNSNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAI 79 Query: 65 FGLGAGLFFIGYFLFEVPSNILMHKVGARIWIARIMITWGILSAAFMFVQNATQFYVLRF 124 +GLGAGLFFIGYF FE+PSNIL+HK+GAR+WIARIMITWG+LSA F FVQ QFY+LRF Sbjct: 80 YGLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRF 139 Query: 125 LLGLAEAGFYPGIILYLTYWFPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHNNGG 184 LLG AEAGFYPG+ILYLTYWFPSHRR + A+F +G P AGI GNPLSGWIMD FH+ G Sbjct: 140 LLGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAG 199 Query: 185 LEGWQWMFLIEAIPAVLIGVATVLYLDNDVKSAKWLSDEEKASLQADIDGDAKGKESKHG 244 +GWQWMF++EAIPAV++GV +LYLDN VK+AKWL++EEKA + DI+ D+KGK + H Sbjct: 200 WQGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASHS 259 Query: 245 FGAIVKDARVWLMCLIYFSFVMGQYGLTLWMPTLVKATGVKGNLEIGLLSAIPFGCAIIA 304 ++VK+ +W+M LIYF FVMGQ+GLTLWMPTL++A+GV N+ IGLL AIPF CAIIA Sbjct: 260 LMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIA 319 Query: 305 MNLIGRSADRMRERRWHLVIPALMGGVGFVGAALFADNTAISIASLSLAAAGVLTCAPLF 364 M + RSAD RERRWHLV+PAL+G VGFV AA A NT +SI LS+AAAGVL CAPLF Sbjct: 320 MVIFSRSADHYRERRWHLVVPALLGAVGFVVAAS-ATNTTVSIIFLSMAAAGVLACAPLF 378 Query: 365 WSLPTAFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHNNATGMYMLAVMLVVGS 424 WSLPTA LSGAAAA GIA INSV NLAGF+SPY++G ++D TH++ GMY+LA L++G+ Sbjct: 379 WSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGA 438 Query: 425 IATLATKPSMVNK 437 L S VN+ Sbjct: 439 AIVLCIPASKVNR 451 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 508 bits (1309), Expect = e-144, Method: Compositional matrix adjust. Identities = 250/420 (59%), Positives = 325/420 (77%), Gaps = 1/420 (0%) Query: 18 KDGLYKKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSQDLGFSETVFGLGAGLFFIGYF 77 ++ Y+KV WR++PFL+LCYV+AYLDRVNVGFAKLQM DL FSETV+GLGAG+FFIGYF Sbjct: 24 EEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGIFFIGYF 83 Query: 78 LFEVPSNILMHKVGARIWIARIMITWGILSAAFMFVQNATQFYVLRFLLGLAEAGFYPGI 137 LFEVPSN+++H+VGAR+WIARIMI+WG++SAA MFV FYV+RFLLGLAEAGF+PGI Sbjct: 84 LFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEAGFFPGI 143 Query: 138 ILYLTYWFPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHNNGGLEGWQWMFLIEAI 197 ILYLTYW+P+ RR + FM+ + ++G++G P+SGW + F GL GWQWMFLIE I Sbjct: 144 ILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWMFLIEGI 203 Query: 198 PAVLIGVATVLYLDNDVKSAKWLSDEEKASLQADIDGDAKGKESKHGFGAIVKDARVWLM 257 P+V+IG+ + YLDN + A+WL+DEEKA L +I + KE AI+ RVWLM Sbjct: 204 PSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDAP-IAAIMASPRVWLM 262 Query: 258 CLIYFSFVMGQYGLTLWMPTLVKATGVKGNLEIGLLSAIPFGCAIIAMNLIGRSADRMRE 317 LIYFSFVMG YG++ W+PTL+K TGV L +GLL+AIP+G A++AM L+ RSADR RE Sbjct: 263 SLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVARSADRTRE 322 Query: 318 RRWHLVIPALMGGVGFVGAALFADNTAISIASLSLAAAGVLTCAPLFWSLPTAFLSGAAA 377 RRWH+ IPAL G +G V +A++ NT +++A+L+L G+LT PLFWSLPTAFL+G A Sbjct: 323 RRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPTAFLAGTGA 382 Query: 378 AVGIAAINSVGNLAGFVSPYLIGYLKDLTHNNATGMYMLAVMLVVGSIATLATKPSMVNK 437 A GIA INS+GNLAGF+SPY +G+LKD T + +GMY+LA +V+G++ TL+ VN+ Sbjct: 383 AAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGALLTLSVPARTVNR 442 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 467 bits (1201), Expect = e-131, Method: Compositional matrix adjust. Identities = 228/441 (51%), Positives = 312/441 (70%), Gaps = 9/441 (2%) Query: 1 MTTASTSGVGLDVNDKSKDGLYKKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSQDLGF 60 M+ +ST + + ++ Y+K W ++P LMLCYV+ YLDRVNVGFAKLQM+ DL F Sbjct: 1 MSESSTESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQF 60 Query: 61 SETVFGLGAGLFFIGYFLFEVPSNILMHKVGARIWIARIMITWGILSAAFMFVQNATQFY 120 S+TV+GLGAG+FFIGYF E+PSN+++H+VGAR+WIARIMITWGI+SA FV FY Sbjct: 61 SDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFY 120 Query: 121 VLRFLLGLAEAGFYPGIILYLTYWFPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFH 180 V+RFLLG+AEAGF+PGIILY++YWFPSHRR +V +F+ +P++GI+G PLSGWIM F+ Sbjct: 121 VMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFN 180 Query: 181 NNGGLEGWQWMFLIEAIPAVLIGVATVLYLDNDVKSAKWLSDEEKASLQADIDGDAKGKE 240 G GWQWMF++E IP+VL+G+ + L + + A WL+D+EK LQ +I+ E Sbjct: 181 GFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIE-----NE 235 Query: 241 SKHGFGAIVKDA----RVWLMCLIYFSFVMGQYGLTLWMPTLVKATGVKGNLEIGLLSAI 296 + H + ++DA RVWL+ LIYF + G Y + W+PTL++ +GVK L IG L+AI Sbjct: 236 AAHYAHSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAI 295 Query: 297 PFGCAIIAMNLIGRSADRMRERRWHLVIPALMGGVGFVGAALFADNTAISIASLSLAAAG 356 P A + M ++ RSADR+RERRWHL + A++G VG + + F+DN +++ L++ A G Sbjct: 296 PSAAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMG 355 Query: 357 VLTCAPLFWSLPTAFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHNNATGMYML 416 L+ PLFWSLPTAFL G+AAA GIA INS GNL GFV+PY++GYLKDLT + TGM ++ Sbjct: 356 ALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLII 415 Query: 417 AVMLVVGSIATLATKPSMVNK 437 + L +G+ VN Sbjct: 416 STTLFIGAALVFLIPAKAVNH 436 >PA4126 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 434 Score = 387 bits (993), Expect = e-107, Method: Compositional matrix adjust. Identities = 207/440 (47%), Positives = 299/440 (67%), Gaps = 10/440 (2%) Query: 1 MTTAST-SGVGLDVNDKSKDGLYKKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSQDLG 59 M+TAST + L ++D + D +V WR+MP L++CYV A+LDR+N+GFAKLQMS DL Sbjct: 1 MSTASTLNSTTLPLSDSTHD----RVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLH 56 Query: 60 FSETVFGLGAGLFFIGYFLFEVPSNILMHKVGARIWIARIMITWGILSAAFMFVQNATQF 119 FS+TV+GLGAGLFFI Y LF +PSN+++ ++G R WIA +M+ WG LS A + V+ A F Sbjct: 57 FSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGF 116 Query: 120 YVLRFLLGLAEAGFYPGIILYLTYWFPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAF 179 Y+LRFLLG+AEAGF+PGI++YL WFP+ RR ++ A+F +P+AG++G PLSGWI++ F Sbjct: 117 YLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGF 176 Query: 180 HNNGGLEGWQWMFLIEAIPAVLIGVATVLYLDNDVKSAKWLSDEEKASLQADIDGDAKGK 239 H+ GL GWQWMFLIE +P VL+GV L + WLSDE+K L+ ++ G+ + + Sbjct: 177 HDALGLRGWQWMFLIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQ-R 235 Query: 240 ESKHGFGAIVKDARVWLMCLIYFSFVMGQYGLTLWMPTLVKATGVKGNLEIGLLSAIPF- 298 ++ F I + +VWL+ IYF+ ++ + WMP+L+ G+ + IG+LSA+P+ Sbjct: 236 KTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYL 295 Query: 299 -GCAIIAMNLIGRSADRMRERRWHLVIPALMGGVGFVGAALFADNTAISIASLSLAAAGV 357 GCA M IGRS+DR+RERRWHL IP LM G AAL + + + L +A G Sbjct: 296 AGCAF--MIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGA 353 Query: 358 LTCAPLFWSLPTAFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHNNATGMYMLA 417 P+FW LP AFLS A A GIA I+S G++A F++PYLIG+++D T + + +Y+LA Sbjct: 354 SAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLA 413 Query: 418 VMLVVGSIATLATKPSMVNK 437 +++ +G+ L T ++VN Sbjct: 414 ILIALGAGLVLRTPAAVVNP 433 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 359 bits (921), Expect = 8e-99, Method: Compositional matrix adjust. Identities = 180/399 (45%), Positives = 256/399 (64%), Gaps = 3/399 (0%) Query: 14 NDKSKDGLYKKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSQDLGFSETVFGLGAGLFF 73 + + +Y V RI+PFL CY+ AYLDR+N+GFAKLQM DL S+ +GLGAG+FF Sbjct: 12 SGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYGLGAGIFF 71 Query: 74 IGYFLFEVPSNILMHKVGARIWIARIMITWGILSAAFMFVQNATQFYVLRFLLGLAEAGF 133 GY LFEVPSN+L+ K+GAR ++RI+I WGI+SA+ +FV + FY LRFLLG+ EAGF Sbjct: 72 FGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLLGVFEAGF 131 Query: 134 YPGIILYLTYWFPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHNNGGLEGWQWMFL 193 PG+I YLT W+P R A+ +AV + P+ G++G P S WIM F GGL GWQWMFL Sbjct: 132 APGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLAGWQWMFL 191 Query: 194 IEAIPAVLIGVATVLYLDNDVKSAKWLSDEEKASLQADIDGDAKGKESKHGFGAIVKDAR 253 E IP++L+G+A YL + A+WL+D +KA + DI A G+ S FG + + + Sbjct: 192 AEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAAPGQASS--FGKALTEPK 249 Query: 254 VWLMCLIYFSFVMGQYGLTLWMPTLVKATGVKGNLEIGLLSAIPFGCAIIAMNLIGRSAD 313 ++++ YF + G Y + W+P+++K+ G+ +IGL SAIP I+AM +GR +D Sbjct: 250 LYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYALGRRSD 309 Query: 314 RMRERRWHLVIPALMGGVGFVGAALFADNTAISIASLSLAAAGVLTCAPLFWSLPTAFLS 373 R ER H I A++ G G + A +A + ++ S++LA+A + +FW++P L Sbjct: 310 RRGERHLHSAITAVL-GAGLLAWAAYATSFPAALISITLASAAIFASYSVFWAIPQQHLK 368 Query: 374 GAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHNNATG 412 G AAA GIA INS+G GF SP LIG+ K+ T + G Sbjct: 369 GTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407