BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0024.0191.p (598 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ d... 714 0.0 NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ d... 414 e-115 NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ d... 410 e-114 alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ d... 382 e-105 slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ d... 357 4e-98 >RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ domain Rso Ralstonia solanacearum Length = 621 Score = 714 bits (1843), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/605 (60%), Positives = 428/605 (70%), Gaps = 18/605 (2%) Query: 4 PIRYRITSLDPASHLYDVSVTVDSPAADGQVFSLPAWIPGSYMIREFGKNIVQLRGESNG 63 PIRY I P +HL+ V+VTVD+P GQ FSLPAWIPGSYMIREF +NIV++ Sbjct: 3 PIRYTIAPAAPEAHLFTVTVTVDAPDPQGQRFSLPAWIPGSYMIREFARNIVRIEAMCGE 62 Query: 64 RKVAVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAHGFE 123 R V + KLDKHTWQAAPC G LT+ Y VYAWDLSVR AHLD THGFFNGTSVFL G E Sbjct: 63 RAVRLAKLDKHTWQAAPCSGPLTVSYDVYAWDLSVRAAHLDPTHGFFNGTSVFLRVEGGE 122 Query: 124 EGEHVVDIARPEGDDFKRWRVATAMPE--------LKAKRYGFGTYVAPNYDALIDHPVE 175 + +VDI P GD ++ WRVATA+ E + AKRYGFG Y A +YD LIDHPVE Sbjct: 123 QVRCLVDIQPPAGDAYRGWRVATALREASGRVQGRVGAKRYGFGWYEAADYDELIDHPVE 182 Query: 176 IGDFALATFQAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPM---- 231 +G FAL +F+A G HD V TGRVPNLDL R+ D K+ICEAQI FEP + AP Sbjct: 183 MGTFALVSFEACGAQHDAVFTGRVPNLDLERIARDFKRICEAQIRLFEPHTAAAPFLDSN 242 Query: 232 NRYVFMTLAVGDGYGGLEHRASTALICSRADLPVKGKPEQTDGYRTYLGLCSHEYFHTWN 291 RYVFMT+ DGYGGLEHRASTALIC+R DLPV G+ E T+GYRT+LGL SHEYFHTWN Sbjct: 243 RRYVFMTMVTTDGYGGLEHRASTALICARNDLPVTGRDETTEGYRTFLGLVSHEYFHTWN 302 Query: 292 VKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDLDNYLKLVGKTVTGV 351 VKRIKPAVF PY L +E +T LLWLFEGFTSYYDDL LVR+G+I YL+++ KT GV Sbjct: 303 VKRIKPAVFVPYALDREVHTPLLWLFEGFTSYYDDLMLVRSGLISEAQYLEMLAKTWNGV 362 Query: 352 LRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRSQTRGRRS 411 LRG+GR KQSVAESSFDAW KYYRQDENA NAIVSYYTKGSLVAL LDLTIR+QT G S Sbjct: 363 LRGSGRLKQSVAESSFDAWTKYYRQDENAPNAIVSYYTKGSLVALALDLTIRTQTGGEHS 422 Query: 412 LDDVMRGLWTRYGRDFY--DGKQQGVPEDEILSIMEALSGADLKRFHDRHIRGTEDVPLV 469 LDDVMR LW GRDFY Q+GV E E++++ME +G L+ + G +D PL Sbjct: 423 LDDVMRALWAAGGRDFYAPGHAQRGVTEAELIALMEETTGLRLRTLVRQLAEGRDDPPLP 482 Query: 470 DLLPAFGVAYEASVPVDAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDG 529 L A GV P +A LGA++G E G KL V++GGPA +AGLSAGD +VA+DG Sbjct: 483 ALFKAIGVT-ATRKPAEAALGLGAKVGAENGFVKLLQVFDGGPAQRAGLSAGDLVVAVDG 541 Query: 530 LRVPASGPDGLLARYRFNDTVRIHAFRRDELMEFSLRLKSDTAPQVTLKPLAKPVAVLRQ 589 LRV + D LAR+R DTV +H FRRDELM+ + L +D PQ L A+P + Sbjct: 542 LRVLSGQLDKSLARHRAGDTVPVHVFRRDELMQLDVTLSADATPQFALALSAEPSPL--- 598 Query: 590 RQAWL 594 R AWL Sbjct: 599 RSAWL 603 >NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nme Neisseria meningitidis MC58 Length = 582 Score = 414 bits (1064), Expect = e-115, Method: Compositional matrix adjust. Identities = 239/588 (40%), Positives = 326/588 (55%), Gaps = 36/588 (6%) Query: 5 IRYRITSLDPASHLYDVSVTVDSPAADGQVFSLPAWIPGSYMIREFGKNIVQLRGESNGR 64 I Y+IT P H + + +T SLP W+PGSY+IR+F ++I + NG Sbjct: 2 IHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHASCNGT 60 Query: 65 KVAVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAHGFEE 124 + ++++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL G E Sbjct: 61 SMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVEGTET 120 Query: 125 GEHVVDIARPEGDDFKRWRVATAMPELKAKRYGFGTYVAPNYDALIDHPVEIGDFALATF 184 H +++ + WR+AT +PE G + A +Y LID PVE+G F Sbjct: 121 LPHRLELTGIPSE----WRIATTLPET-----GRFVFQAASYAELIDRPVEMGLIEFLDF 171 Query: 185 QAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMNRYVFMTLAVGDG 244 +A G+PH + ++G P+ D RL D+KKICE ++A F S AP +Y+F+ L VGD Sbjct: 172 EAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELAVF---SSPAPFQKYLFL-LHVGDH 227 Query: 245 -YGGLEHRASTALICSRADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAVFAPY 303 YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA F PY Sbjct: 228 IYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAAFVPY 287 Query: 304 DLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDLDNYLKLVGKTVTGVLRGTGRKKQSVA 363 DL +ENYT LW FEG TSYYDDLFL R+ I ++YL L+ + +T V + GR +Q++A Sbjct: 288 DLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLRQTLA 347 Query: 364 ESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRSQTRGRRSLDDVMRGLWTRY 423 ESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL IR+++ GR SLD +M L+ R Sbjct: 348 ESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTLMDKLY-RE 406 Query: 424 GRDFYDGKQQGVPEDEILSIMEALSGADLKRFHDRHIRGTEDVPLVDLLPAFGVAY---- 479 RD G+PE + ++G DL+ F + + TED+PL + L GV Sbjct: 407 WRD----THSGIPEKHWQIRCQEITGLDLEDFFQKALYSTEDLPLAECLATAGVGLTFLP 462 Query: 480 ----------EASVPVDAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDG 529 E PV + GAR + L V+ GG A A L DK++A+DG Sbjct: 463 LPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKIIALDG 522 Query: 530 LRVPASGPDGLLARYRFNDTVRIHAFRRDELMEFSLRLKSDTAPQVTL 577 + ARY N + IH FR L + L +++ A L Sbjct: 523 --YACTDFTAQWARYHVNAKINIHFFRAGILRQTVLTVQAAAADTAIL 568 >NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ domain NmA Neisseria meningitidis Z2491 Length = 585 Score = 410 bits (1054), Expect = e-114, Method: Compositional matrix adjust. Identities = 241/592 (40%), Positives = 327/592 (55%), Gaps = 36/592 (6%) Query: 1 MATPIRYRITSLDPASHLYDVSVTVDSPAADGQVFSLPAWIPGSYMIREFGKNIVQLRGE 60 M I Y+IT P H + + +T SLP W+PGSY+IR+F ++I + Sbjct: 1 MIVMIHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHAS 59 Query: 61 SNGRKVAVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAH 120 NG + ++++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL Sbjct: 60 CNGTSMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVE 119 Query: 121 GFEEGEHVVDIARPEGDDFKRWRVATAMPELKAKRYGFGTYVAPNYDALIDHPVEIGDFA 180 G E H +++ G +R R+AT +PE G + A +Y LID PVE+G Sbjct: 120 GTETLLHRLELT---GIPSER-RIATTLPET-----GRFVFQAASYAELIDRPVEMGLIE 170 Query: 181 LATFQAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMNRYVFMTLA 240 F+A G+PH + ++G P+ D RL D+KKICE ++ F S AP +Y+F+ L Sbjct: 171 FLDFEAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELTVF---SSPAPFQKYLFL-LH 226 Query: 241 VGDG-YGGLEHRASTALICSRADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAV 299 VGD YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA Sbjct: 227 VGDHIYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAA 286 Query: 300 FAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDLDNYLKLVGKTVTGVLRGTGRKK 359 F PYDL +ENYT LW FEG TSYYDDLFL R+ I ++YL L+ + +T V + GR + Sbjct: 287 FVPYDLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLR 346 Query: 360 QSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRSQTRGRRSLDDVMRGL 419 Q++AESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL IR+++ GR SLD VM L Sbjct: 347 QTLAESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTVMDKL 406 Query: 420 WTRYGRDFYDGKQQGVPEDEILSIMEALSGADLKRFHDRHIRGTEDVPLVDLLPAFGVAY 479 + R RD G+PE + ++G DL+ F + + TED+PL + L GV Sbjct: 407 Y-REWRD----THSGIPEKHWQIRCQEITGLDLEDFFQKTLYSTEDLPLAECLATAGVGL 461 Query: 480 --------------EASVPVDAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLV 525 E PV + GAR + L V+ GG A A L DK++ Sbjct: 462 TFLPLPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKII 521 Query: 526 AIDGLRVPASGPDGLLARYRFNDTVRIHAFRRDELMEFSLRLKSDTAPQVTL 577 A+DG + ARY N + IH FR L + L +++ A L Sbjct: 522 ALDG--YACTDFTAQWARYHVNAKINIHFFRAGILRQTVLTVQAAAADTAIL 571 >alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nos Nostoc sp. PCC 7120 Length = 543 Score = 382 bits (980), Expect = e-105, Method: Compositional matrix adjust. Identities = 204/563 (36%), Positives = 315/563 (55%), Gaps = 27/563 (4%) Query: 37 LPAWIPGSYMIREFGKNIVQLRGESNGRKVAVKKLDKHTWQAAPCK-GALTLHYQVYAWD 95 +P W PGSY++RE+ KN+ + + + +K+ K+ WQ +T+ Y+++A + Sbjct: 1 MPVWTPGSYLVREYAKNLQDFTAFAGDKILPWRKISKNHWQINKGDVSEVTVRYRIFANE 60 Query: 96 LSVRTAHLDRTHGFFNGTSVFLAAHGFEEGEHVVDIARPEGDDFKRWRVATAMPELKAKR 155 LSVRT HLD THG+FNG ++F G+E V + P + +WRV T +P + + Sbjct: 61 LSVRTNHLDATHGYFNGAALFFRLPGWENLPICVTVIPP----YPQWRVTTPLPTIGEQS 116 Query: 156 YGFGTYVAPNYDALIDHPVEIGDFALATFQAHGVPHDVVITGRVPNLDLARLCDDLKKIC 215 T+ A ++D L+D P EIG+ L F+ G PH++ I G+ N + +L D +KI Sbjct: 117 ---NTFYAADFDTLVDSPFEIGEHQLYHFEVLGKPHELAIWGQ-GNCQVQQLIRDTQKII 172 Query: 216 EAQIAFFEPRSKRAPMNRYVFMTLAVGDGYGGLEHRASTALICSRADLPVKGKPEQTDGY 275 + + F P RYVF+ YGGLEH+ S +LI R D Y Sbjct: 173 QIEAQMF----GGLPYERYVFLLHLFAQAYGGLEHKNSCSLIYQRFGF------RSQDKY 222 Query: 276 RTYLGLCSHEYFHTWNVKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVI 335 ++ L +HE+FH WNVKRI+P ++ QENYT LW EG TSYYD L +R G+ Sbjct: 223 ERFIQLLAHEFFHLWNVKRIRPQALEVFNYDQENYTPSLWFCEGTTSYYDLLIPLRAGIY 282 Query: 336 DLDNYLKLVGKTVTGVLRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVA 395 D YL K ++ ++ GRK Q ++ESSFDAW+K YR D N N+ VSYY KG +++ Sbjct: 283 DAKTYLNYWSKEISRLITTPGRKVQPLSESSFDAWIKLYRPDTNTGNSQVSYYLKGEMIS 342 Query: 396 LGLDLTIRSQTRGRRSLDDVMRGLWTRYGRDFYDGKQQGVPEDEILSIMEALSGADLKRF 455 L LDL IR++ R +RSLDDVMR +W ++G+ + G +++ +++E+++G DL F Sbjct: 343 LLLDLLIRARYRNQRSLDDVMRQMWQKFGQ-----AEIGYTPEQLQAVIESVAGVDLTDF 397 Query: 456 HDRHIRGTEDVPLVDLLPAFGVAYEASVPVDAKPWLGARIGKEGGDAKLAAVYEGGPAMQ 515 R+I GTE++P L FG+ A + +P+LG ++ E G + V G PA Sbjct: 398 FARYIDGTEELPFNQYLEPFGLHLVAE--REEEPYLGVKVNTENGREMIKFVEAGSPAQM 455 Query: 516 AGLSAGDKLVAIDGLRVPASGPDGLLARYRFNDTVRIHAFRRDELMEFSLRLKSDTAPQV 575 AG+ AGD+L+AI G+++ A L Y+ NDT+++ F +DEL + ++L + + Sbjct: 456 AGIDAGDELLAIAGIKITAHQLSDRLKDYQANDTIQVTVFHQDELRTYPVKLGTPRPTKY 515 Query: 576 TLKPLAKPVAVLRQR-QAWLNSG 597 L + P A ++ AWL + Sbjct: 516 QLLAIQNPNATQQENFAAWLGAA 538 >slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ domain Syn Synechocystis Length = 584 Score = 357 bits (917), Expect = 4e-98, Method: Compositional matrix adjust. Identities = 210/596 (35%), Positives = 316/596 (53%), Gaps = 28/596 (4%) Query: 5 IRYRITSLDPASHLYDVSVTVDSPAADGQVFSLPAWIPGSYMIREFGKNI--VQLRGESN 62 + Y++ P +H + V + + A P W PGSY++RE+ +++ Q +G SN Sbjct: 8 LHYQVAMPTPQTHYFTVDLHIQGFTASVLELKFPVWTPGSYLVREYERHLQDFQAQGLSN 67 Query: 63 GRKVAVKKLDKHTWQAAPC--KGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAH 120 G + +KL K W A C + + + Y++YA +L+VRT HLD +HGFF G ++F Sbjct: 68 GEYLEHQKLGKAHW-AIACGEEENIAISYRIYADELTVRTNHLDYSHGFFTGAALFFYLP 126 Query: 121 GFEEGEHVVDIARPEGDDFKRWRVATAMP-ELKAKRYGFGTYVAPNYDALIDHPVEIGDF 179 G + + PE W +ATA+P + G T+ A ++D L+D PVE+G Sbjct: 127 GHTHRPLALTVVPPE----PAWAIATALPCKATDSTTGAKTFYAQDFDTLVDSPVEVGIH 182 Query: 180 ALATFQAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMNRYVFMTL 239 F+ G H V+ G NL+ +L D +KI + F P + Y F+ Sbjct: 183 RDYAFETQGKEHHFVVWGE-SNLNGEQLVRDTEKIIAVEAGLF----GNLPYDHYWFILH 237 Query: 240 AVGDGYGGLEHRASTALICSRADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAV 299 GYGGLEH+ S L R PE+ Y+ +L L +HE+FH WN+KRI+P Sbjct: 238 TSNQGYGGLEHKDSCVLNYDRFGF---RDPEK---YQRFLQLVAHEFFHLWNIKRIRPIA 291 Query: 300 FAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDLDNYLKLVGKTVTGVLRGTGRKK 359 +D QENYT LW EG TSYYD L +R + D YLK +GK +T L+ GR Sbjct: 292 LEKFDYDQENYTPSLWFSEGTTSYYDLLIPLRAEIYDRQTYLKNLGKEITRYLKTLGRLV 351 Query: 360 QSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRSQTRGRRSLDDVMRGL 419 Q +AESSFDAW+K YR+D N+ N+ +SYY KG LV L LDL IR + + +RS DDV+R + Sbjct: 352 QPLAESSFDAWIKLYRRDANSDNSQMSYYLKGELVTLMLDLLIRERHQNQRSFDDVLRAM 411 Query: 420 WTRYGRDFYDGKQQGVPEDEILSIMEALSGADLKRFHDRHIRGTEDVPLVDLLPAFGVAY 479 W +GR+ + G +++ +++ ++ DL F ++ T ++PL D L FG+ Sbjct: 412 WQEFGRE-----EIGFTPEQLQAVISRVADTDLTEFFHTYLHTTAELPLNDYLQPFGLVI 466 Query: 480 EASVPVDAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDGLRVPASGPDG 539 + + D P+LG ++ E G K+ V PA AG+S D L+AI+G+RV A Sbjct: 467 KP-MQEDLTPYLGIKVKSEAGQEKITFVAAHSPAAMAGISPQDLLLAINGVRVGAEQLSL 525 Query: 540 LLARYRFNDTVRIHAFRRDELMEFSLRLKSDTAPQVTLKPLAKPV-AVLRQRQAWL 594 L Y+ ND +++ F +D L + L S A + + P+A P + L+ WL Sbjct: 526 RLKDYQANDMIQLTVFHQDLLRTVDVVLASPQANRYEVVPIADPSDSQLQNLAGWL 581